3IWK

crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum (psamadh1)

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 369
  • Norm. En. per Res.: -4.121
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-314.245	-59.2576	-1103.79	-1477.2926	373	40	22	43625	5	72	81
A-D	-14.621	-12.099	-80.2909	-107.0109	43	1	0	3507	0	16	13
A-J	0.0	0.0	-0.0131	-0.0131	3	0	0	3	0	3	3
A-K	0.0	0.0	-0.0795	-0.0795	2	0	0	10	0	1	3
A-L	0.0	-66.6018	-73.9	-140.5018	51	1	2	3220	6	28	25
B-C	-24.4059	-12.9709	-79.6678	-117.0446	40	6	0	3505	0	15	12
B-F	0.0	5.7256	-0.6757	5.0499	10	0	0	78	0	3	4
B-I	0.0	0.0794	-19.7927	-19.7133	29	0	0	887	3	13	9
B-J	-2.9594	-11.2821	-2.6455	-16.887	13	0	0	147	1	15	9
C-D	-293.1074	-37.511	-1106.99	-1437.6085	371	45	20	43740	2	70	79
C-J	-18.9389	-68.8693	-69.0199	-156.8281	52	4	2	3265	4	26	24
D-J	0.0	0.0	-1.1787	-1.1787	4	0	0	132	0	1	2
E-F	-309.9195	-53.8805	-1096.63	-1460.4301	368	41	21	43115	7	67	79
F-K	0.0	-2.8829	-18.7744	-21.6573	30	0	0	1032	1	14	9
F-L	-9.8536	-14.3612	-5.0945	-29.3093	11	0	0	201	3	13	8
G-H	-306.7831	-50.3576	-1098.65	-1455.7907	368	45	21	43450	5	70	81
G-I	0.0	0.0	-0.0416	-0.0416	2	0	0	19	0	1	2
G-J	-4.7492	-56.712	-78.6584	-140.1196	51	3	3	3466	6	29	27
H-L	0.0	4.157	-19.6656	-15.5086	26	0	0	957	0	5	7
I-J	-329.826	-94.8275	-1096.01	-1520.6635	369	45	20	43121	8	70	78
K-L	-300.0141	-47.5547	-893.495	-1241.0637	376	54	19	43004	4	64	78

Interface residues

• A-B: ALA107A, ALA107B, ALA109A, ALA109B, ALA116A, ALA116B, ALA134A, ALA134B, ALA241A, ALA241B, ALA250A, ALA250B, ALA251A, ALA251B, ALA279A, ALA279B, ALA318A, ALA318B, ALA424A, ALA424B, ALA439A, ALA439B, ALA442A, ALA442B, ALA450A, ALA450B, ALA457A, ALA457B, ALA68A, ALA68B, ALA69B, ARG332A, ARG332B, ARG435A, ARG435B, ARG464A, ARG464B, ARG469A, ARG469B, ARG487A, ARG487B, ARG60A, ASN290A, ASN290B, ASN320A, ASN320B, ASN412B, ASN415A, ASN415B, ASN428A, ASN428B, ASN448A, ASN448B, ASN62B, ASP110B, ASP113B, ASP230A, ASP230B, ASP232A, ASP232B, ASP274A, ASP274B, ASP276A, ASP276B, ASP312A, ASP312B, ASP491A, ASP491B, CYS286A, CYS286B, CYS331A, CYS331B, CYS433A, CYS433B, CYS449A, CYS449B, GLN132A, GLN132B, GLN252A, GLN252B, GLN441A, GLN441B, GLN451A, GLN451B, GLN456A, GLN456B, GLN484A, GLN484B, GLN498A, GLN498B, GLU105A, GLU105B, GLU106A, GLU106B, GLU150A, GLU150B, GLU280A, GLU280B, GLU319A, GLU319B, GLU407A, GLU407B, GLU408A, GLU408B, GLU431B, GLU434A, GLU434B, GLU470A, GLU470B, GLU473A, GLU473B, GLU477A, GLU477B, GLU492A, GLU492B, GLY153A, GLY153B, GLY243A, GLY243B, GLY262A, GLY262B, GLY285A, GLY285B, GLY291A, GLY291B, GLY330A, GLY330B, GLY334A, GLY422A, GLY422B, GLY443A, GLY443B, GLY460A, GLY460B, GLY461A, GLY461B, GLY466A, GLY466B, GLY468A, GLY468B, GLY472A, GLY472B, GLY495A, GLY495B, HIS228A, HIS418A, HIS418B, ILE136A, ILE136B, ILE147A, ILE147B, ILE152A, ILE152B, ILE234A, ILE234B, ILE246A, ILE246B, ILE293A, ILE293B, ILE321A, ILE321B, ILE323B, ILE411A, ILE411B, ILE444A, ILE444B, ILE447A, ILE447B, ILE455A, ILE455B, ILE462A, ILE462B, ILE58A, ILE58B, LEU104A, LEU104B, LEU108A, LEU108B, LEU138A, LEU138B, LEU148A, LEU148B, LEU253A, LEU253B, LEU259A, LEU259B, LEU261A, LEU261B, LEU314A, LEU314B, LEU333A, LEU333B, LEU421A, LEU421B, LEU430A, LEU430B, LEU436A, LEU436B, LEU440A, LEU440B, LEU471A, LEU471B, LEU480A, LEU480B, LYS102A, LYS102B, LYS133A, LYS133B, LYS144A, LYS144B, LYS149A, LYS149B, LYS233A, LYS233B, LYS245A, LYS245B, LYS255A, LYS255B, LYS277A, LYS277B, LYS313A, LYS313B, LYS316A, LYS316B, LYS322A, LYS322B, LYS438A, LYS438B, LYS463A, LYS463B, LYS483A, LYS483B, LYS502A, LYS55A, LYS55B, LYS61A, MET140A, MET140B, MET247A, MET247B, MET426A, MET426B, PHE143A, PHE143B, PHE236A, PHE236B, PHE284A, PHE284B, PHE287A, PHE287B, PHE288A, PHE288B, PHE454A, PHE454B, PHE467A, PHE467B, PRO103A, PRO103B, PRO135A, PRO135B, PRO139A, PRO139B, PRO151A, PRO151B, PRO229A, PRO229B, PRO256A, PRO256B, PRO377A, PRO377B, PRO397A, PRO452A, PRO452B, PRO458A, PRO458B, PRO493A, PRO493B, PRO499A, PRO499B, PRO500A, PRO500B, SER137A, SER137B, SER145A, SER145B, SER239A, SER239B, SER240A, SER240B, SER244A, SER244B, SER258A, SER258B, SER423A, SER423B, SER427A, SER427B, SER437A, SER437B, SER453A, SER453B, SER465A, SER465B, SER481A, SER481B, SER490A, SER490B, SER501A, SER501B, SER59A, SER59B, SER70B, THR142A, THR142B, THR242A, THR242B, THR248A, THR248B, THR249A, THR249B, THR282A, THR282B, THR289A, THR289B, THR486A, THR486B, THR489A, THR489B, TRP170A, TRP281A, TRP281B, TRP317A, TRP317B, TRP446A, TRP446B, TRP459A, TRP459B, TRP474A, TRP474B, TRP494A, TRP494B, TRP496A, TRP496B, TYR120A, TYR120B, TYR146A, TYR146B, TYR419A, TYR419B, TYR488A, TYR488B, TYR497A, TYR497B, VAL231A, VAL231B, VAL254A, VAL254B, VAL257A, VAL257B, VAL278A, VAL278B, VAL283A, VAL283B, VAL315A, VAL315B, VAL425A, VAL425B, VAL445A, VAL445B, VAL482A, VAL482B, VAL485A, VAL485B
• A-D: ALA352A, ALA357A, ARG17D, ARG208D, ARG24D, ARG391A, ARG56D, ARG8D, ASN22D, ASN347A, ASP13D, ASP382A, ASP46D, CYS348A, GLN388A, GLN9D, GLU15D, GLU355A, GLU392A, GLU45D, GLY356A, ILE12D, ILE20D, ILE389A, LEU10D, LEU21D, LEU49D, LYS202D, LYS23D, LYS344A, LYS353A, MET387A, PRO19D, SER350A, SER351A, SER354A, SER386A, SER7D, THR384A, THR385A, TRP16D, VAL18D, VAL383A
• A-J: ARG435A, GLU329J, GLU431A
• A-K: GLY63A, LYS502K
• A-L: ALA307L, ALA69A, ALA75A, ALA80A, ALA83A, ARG64A, ARG74A, ARG76A, ARG79A, ASP312L, ASP382L, CYS201A, GLU203A, GLU304L, GLU309L, GLU409L, GLU87A, GLY205A, GLY63A, HIS303L, ILE200A, ILE306L, ILE359L, ILE81A, LEU206A, LEU275L, LEU360L, LEU73A, LEU78A, LYS202A, LYS313L, LYS316L, LYS84A, LYS88A, PHE310L, PHE404L, PRO207A, SER305L, SER405L, SER70A, SER72A, THR358L, THR381L, THR403L, THR406L, TRP66A, TYR77A, VAL204A, VAL308L, VAL311L, VAL315L
• B-C: ALA352C, ALA357C, ARG17B, ARG24B, ARG391C, ARG56B, ARG8B, ASN22B, ASN347C, ASP13B, ASP382C, ASP46B, CYS348C, GLN388C, GLN9B, GLU15B, GLU355C, GLU392C, GLY356C, ILE12B, ILE20B, ILE389C, LEU10B, LEU21B, LEU49B, LYS202B, LYS344C, LYS353C, MET387C, PRO19B, SER350C, SER351C, SER354C, SER386C, SER7B, THR384C, THR385C, TRP16B, VAL18B, VAL383C
• B-F: ASP141F, GLU271B, GLU304B, ILE306B, LEU138F, MET140F, PRO139F, SER137F, SER305B, SER405B
• B-I: ALA122B, ALA75B, ALA80B, ALA82B, ALA83B, ARG76B, ARG79B, ASP141I, ASP491I, GLN498I, GLU126B, GLU203B, GLU492I, GLU87B, GLY123B, GLY495I, ILE81B, LEU138I, LYS84B, MET140I, PRO139I, PRO493I, SER490I, SER72B, THR142I, TRP494I, TRP496I, TYR488I, VAL204B
• B-J: ARG208B, ARG332J, ARG64B, ARG76B, ASP65B, ASP90J, GLU329J, GLU87J, LEU104J, LEU108J, LYS61B, LYS86J, LYS89J
• C-D: ALA107C, ALA107D, ALA109C, ALA109D, ALA116C, ALA116D, ALA134C, ALA134D, ALA241C, ALA241D, ALA250C, ALA250D, ALA251C, ALA251D, ALA279C, ALA279D, ALA318C, ALA318D, ALA424C, ALA424D, ALA439C, ALA439D, ALA442C, ALA442D, ALA450C, ALA450D, ALA457C, ALA457D, ALA68C, ALA68D, ALA69D, ARG332C, ARG332D, ARG435C, ARG435D, ARG464C, ARG464D, ARG469C, ARG469D, ARG487C, ARG487D, ARG60C, ARG64D, ASN290C, ASN290D, ASN320C, ASN320D, ASN412D, ASN415C, ASN415D, ASN428C, ASN428D, ASN448C, ASN448D, ASN62C, ASN62D, ASP110C, ASP110D, ASP113C, ASP113D, ASP141C, ASP141D, ASP230C, ASP230D, ASP232C, ASP232D, ASP274C, ASP274D, ASP276C, ASP276D, ASP312C, ASP312D, ASP429D, ASP491C, ASP491D, CYS286C, CYS286D, CYS331C, CYS331D, CYS433C, CYS433D, CYS449C, CYS449D, GLN132C, GLN132D, GLN252C, GLN252D, GLN441C, GLN441D, GLN451C, GLN451D, GLN456C, GLN456D, GLN484C, GLN484D, GLN498C, GLN498D, GLU105C, GLU105D, GLU106C, GLU106D, GLU150C, GLU150D, GLU260C, GLU260D, GLU280C, GLU280D, GLU319C, GLU319D, GLU407C, GLU407D, GLU408C, GLU408D, GLU431C, GLU434C, GLU434D, GLU470C, GLU470D, GLU473C, GLU473D, GLU477C, GLU477D, GLU492C, GLU492D, GLY153C, GLY153D, GLY243C, GLY243D, GLY285C, GLY285D, GLY291C, GLY291D, GLY330C, GLY330D, GLY422C, GLY422D, GLY443C, GLY443D, GLY460C, GLY460D, GLY461C, GLY461D, GLY466C, GLY466D, GLY468C, GLY468D, GLY472C, GLY472D, GLY495C, GLY495D, HIS418C, HIS418D, ILE136C, ILE136D, ILE147C, ILE147D, ILE152C, ILE152D, ILE234C, ILE234D, ILE246C, ILE246D, ILE293C, ILE293D, ILE321C, ILE321D, ILE411C, ILE411D, ILE444C, ILE444D, ILE447C, ILE447D, ILE455C, ILE455D, ILE462C, ILE462D, ILE58C, ILE58D, LEU104C, LEU104D, LEU108C, LEU108D, LEU138C, LEU138D, LEU148C, LEU148D, LEU253C, LEU253D, LEU259C, LEU259D, LEU261C, LEU261D, LEU314C, LEU314D, LEU333C, LEU333D, LEU421C, LEU421D, LEU430C, LEU430D, LEU436C, LEU436D, LEU440C, LEU440D, LEU471C, LEU471D, LEU480C, LEU480D, LYS102C, LYS102D, LYS133C, LYS133D, LYS144C, LYS144D, LYS149C, LYS149D, LYS233C, LYS233D, LYS245C, LYS245D, LYS255C, LYS255D, LYS277C, LYS277D, LYS313C, LYS313D, LYS316C, LYS316D, LYS322C, LYS322D, LYS438C, LYS438D, LYS463C, LYS463D, LYS483C, LYS483D, LYS502D, LYS55C, LYS55D, LYS61C, MET140C, MET140D, MET247C, MET247D, MET426C, MET426D, PHE143C, PHE143D, PHE236C, PHE236D, PHE284C, PHE284D, PHE287C, PHE287D, PHE288C, PHE288D, PHE454C, PHE454D, PHE467C, PHE467D, PRO103C, PRO103D, PRO139C, PRO139D, PRO151C, PRO151D, PRO229C, PRO229D, PRO256C, PRO256D, PRO377C, PRO377D, PRO397C, PRO397D, PRO452C, PRO452D, PRO458C, PRO458D, PRO493C, PRO493D, PRO499C, PRO499D, PRO500C, PRO500D, SER137C, SER137D, SER145C, SER145D, SER239C, SER239D, SER240C, SER240D, SER244C, SER244D, SER258C, SER423C, SER423D, SER427C, SER427D, SER437C, SER437D, SER453C, SER453D, SER465C, SER465D, SER481C, SER481D, SER490C, SER490D, SER501C, SER501D, SER59C, SER59D, THR142C, THR142D, THR242C, THR242D, THR248C, THR248D, THR249C, THR249D, THR282C, THR282D, THR289C, THR289D, THR486C, THR486D, THR489C, THR489D, TRP281C, TRP281D, TRP317C, TRP317D, TRP446C, TRP446D, TRP459C, TRP459D, TRP474C, TRP474D, TRP494C, TRP494D, TRP496C, TRP496D, TYR120C, TYR120D, TYR146C, TYR146D, TYR488C, TYR488D, TYR497C, TYR497D, VAL231C, VAL231D, VAL254C, VAL254D, VAL257C, VAL257D, VAL278C, VAL278D, VAL283C, VAL283D, VAL315C, VAL315D, VAL425C, VAL425D, VAL445C, VAL445D, VAL482C, VAL482D, VAL485C, VAL485D
• C-J: ALA307C, ALA69J, ALA75J, ALA80J, ALA83J, ARG208J, ARG64J, ARG74J, ARG76J, ARG79J, ASP312C, ASP382C, CYS201J, GLU126J, GLU203J, GLU304C, GLU309C, GLU409C, GLU87J, GLY205J, GLY63J, HIS303C, ILE200J, ILE306C, ILE81J, LEU206J, LEU275C, LEU360C, LEU73J, LEU78J, LYS202J, LYS313C, LYS316C, LYS84J, PHE310C, PHE404C, PRO207J, SER305C, SER405C, SER70J, SER72J, THR358C, THR361C, THR381C, THR403C, THR406C, TRP66J, TYR77J, VAL204J, VAL308C, VAL311C, VAL315C
• D-J: ARG64J, ASN62J, GLY63J, LYS502D
• E-F: ALA107E, ALA107F, ALA109E, ALA109F, ALA116E, ALA116F, ALA134E, ALA134F, ALA241E, ALA241F, ALA250E, ALA250F, ALA251E, ALA251F, ALA279E, ALA279F, ALA318E, ALA318F, ALA410F, ALA424E, ALA424F, ALA439E, ALA439F, ALA442E, ALA442F, ALA450E, ALA450F, ALA457E, ALA457F, ALA68E, ALA68F, ARG332E, ARG332F, ARG435E, ARG435F, ARG464E, ARG464F, ARG469E, ARG469F, ARG487E, ARG487F, ARG60E, ARG64F, ASN290E, ASN290F, ASN320E, ASN320F, ASN412E, ASN412F, ASN415E, ASN415F, ASN428E, ASN428F, ASN448E, ASN448F, ASN62F, ASP141E, ASP230E, ASP230F, ASP232E, ASP232F, ASP274E, ASP274F, ASP276E, ASP276F, ASP312E, ASP312F, ASP491E, ASP491F, CYS286E, CYS286F, CYS331E, CYS331F, CYS433E, CYS433F, CYS449E, CYS449F, GLN132E, GLN132F, GLN252E, GLN252F, GLN441E, GLN441F, GLN451E, GLN451F, GLN456E, GLN456F, GLN484E, GLN484F, GLN498E, GLN498F, GLU105E, GLU105F, GLU106E, GLU106F, GLU150E, GLU150F, GLU260E, GLU260F, GLU280E, GLU280F, GLU319E, GLU319F, GLU407F, GLU408E, GLU408F, GLU409F, GLU431F, GLU434E, GLU434F, GLU470E, GLU470F, GLU473E, GLU473F, GLU477E, GLU477F, GLU492E, GLU492F, GLY153E, GLY153F, GLY243E, GLY243F, GLY262E, GLY285E, GLY285F, GLY291E, GLY291F, GLY330E, GLY330F, GLY422E, GLY422F, GLY443E, GLY443F, GLY460E, GLY460F, GLY461E, GLY461F, GLY466E, GLY466F, GLY468E, GLY468F, GLY472E, GLY472F, GLY495E, GLY495F, HIS418E, HIS418F, ILE136E, ILE136F, ILE147E, ILE147F, ILE152E, ILE152F, ILE234E, ILE234F, ILE246E, ILE246F, ILE293E, ILE293F, ILE321E, ILE321F, ILE411E, ILE411F, ILE444E, ILE444F, ILE447E, ILE447F, ILE455E, ILE455F, ILE462E, ILE462F, ILE58E, ILE58F, LEU104E, LEU104F, LEU108E, LEU108F, LEU138E, LEU138F, LEU148E, LEU148F, LEU253E, LEU253F, LEU259E, LEU259F, LEU261E, LEU261F, LEU314E, LEU314F, LEU333E, LEU333F, LEU413F, LEU421E, LEU421F, LEU430E, LEU430F, LEU436E, LEU436F, LEU440E, LEU440F, LEU471E, LEU471F, LEU480E, LEU480F, LYS102E, LYS102F, LYS133E, LYS133F, LYS144E, LYS144F, LYS149E, LYS149F, LYS233E, LYS233F, LYS245E, LYS245F, LYS255E, LYS255F, LYS277E, LYS277F, LYS313E, LYS313F, LYS316E, LYS316F, LYS322E, LYS322F, LYS438E, LYS438F, LYS463E, LYS463F, LYS483E, LYS483F, LYS502E, LYS55E, LYS55F, LYS61E, MET140E, MET140F, MET247E, MET247F, MET426E, MET426F, PHE143E, PHE143F, PHE236E, PHE236F, PHE284E, PHE284F, PHE287E, PHE287F, PHE288E, PHE288F, PHE454E, PHE454F, PHE467E, PHE467F, PRO103E, PRO103F, PRO135F, PRO139E, PRO139F, PRO151E, PRO151F, PRO229E, PRO229F, PRO256E, PRO256F, PRO377E, PRO377F, PRO397E, PRO397F, PRO452E, PRO452F, PRO458E, PRO458F, PRO493E, PRO493F, PRO499E, PRO499F, PRO500E, PRO500F, SER137E, SER137F, SER145E, SER145F, SER239E, SER239F, SER240E, SER240F, SER244E, SER244F, SER258F, SER423E, SER423F, SER427E, SER427F, SER437E, SER437F, SER453E, SER453F, SER465E, SER465F, SER481E, SER481F, SER490E, SER490F, SER501E, SER501F, SER59E, SER59F, THR142E, THR142F, THR242E, THR242F, THR248E, THR248F, THR249E, THR249F, THR282E, THR282F, THR289E, THR289F, THR486E, THR486F, THR489E, THR489F, TRP281E, TRP281F, TRP317E, TRP317F, TRP446E, TRP446F, TRP459E, TRP459F, TRP474E, TRP474F, TRP494E, TRP494F, TRP496E, TRP496F, TYR120E, TYR120F, TYR146E, TYR146F, TYR488E, TYR488F, TYR497E, TYR497F, VAL231E, VAL231F, VAL254E, VAL254F, VAL257E, VAL257F, VAL278E, VAL278F, VAL283E, VAL283F, VAL315E, VAL315F, VAL425E, VAL425F, VAL445E, VAL445F, VAL482E, VAL482F, VAL485E, VAL485F
• F-K: ALA122F, ALA75F, ALA80F, ALA83F, ARG76F, ARG79F, ASP141K, ASP491K, GLU126F, GLU203F, GLU492K, GLU87F, GLY123F, GLY495K, ILE81F, LEU138K, LYS84F, LYS86F, MET140K, PHE143K, PRO139K, PRO493K, SER137K, SER490K, SER72F, THR142K, TRP494K, TRP496K, TYR488K, VAL204F
• F-L: ARG64F, ASP65F, ASP90L, GLU105L, GLU329L, GLU87L, GLY330L, LEU108L, LYS61F, LYS86L, LYS89L
• G-H: ALA107G, ALA107H, ALA109G, ALA109H, ALA116G, ALA116H, ALA134G, ALA134H, ALA241G, ALA241H, ALA250G, ALA250H, ALA251G, ALA251H, ALA279G, ALA279H, ALA318G, ALA318H, ALA424G, ALA424H, ALA439G, ALA439H, ALA442G, ALA442H, ALA450G, ALA450H, ALA457G, ALA457H, ALA68G, ALA68H, ARG332G, ARG332H, ARG435G, ARG435H, ARG464G, ARG464H, ARG469G, ARG469H, ARG487G, ARG487H, ARG60G, ASN290G, ASN290H, ASN320G, ASN320H, ASN412H, ASN415G, ASN415H, ASN428G, ASN428H, ASN448G, ASN448H, ASN62H, ASP110H, ASP113G, ASP113H, ASP230G, ASP230H, ASP232G, ASP232H, ASP274G, ASP274H, ASP276G, ASP276H, ASP312G, ASP312H, ASP491G, ASP491H, CYS286G, CYS286H, CYS331G, CYS331H, CYS433G, CYS433H, CYS449G, CYS449H, GLN132G, GLN132H, GLN252G, GLN252H, GLN441G, GLN441H, GLN451G, GLN451H, GLN456G, GLN456H, GLN484G, GLN484H, GLN498G, GLN498H, GLU105G, GLU105H, GLU106G, GLU106H, GLU150G, GLU150H, GLU260G, GLU260H, GLU280G, GLU280H, GLU319G, GLU319H, GLU408G, GLU408H, GLU431H, GLU434G, GLU434H, GLU470G, GLU470H, GLU473G, GLU473H, GLU477G, GLU477H, GLU492G, GLU492H, GLY153G, GLY153H, GLY243G, GLY243H, GLY262H, GLY285G, GLY285H, GLY291G, GLY291H, GLY330G, GLY330H, GLY422G, GLY422H, GLY443G, GLY443H, GLY460G, GLY460H, GLY461G, GLY461H, GLY466G, GLY466H, GLY468G, GLY468H, GLY472G, GLY472H, GLY495G, GLY495H, HIS418G, HIS418H, ILE136G, ILE136H, ILE147G, ILE147H, ILE152G, ILE152H, ILE234G, ILE234H, ILE246G, ILE246H, ILE293G, ILE293H, ILE321G, ILE321H, ILE411G, ILE411H, ILE444G, ILE444H, ILE447G, ILE447H, ILE455G, ILE455H, ILE462G, ILE462H, ILE58G, ILE58H, LEU104G, LEU104H, LEU108G, LEU108H, LEU138G, LEU138H, LEU148G, LEU148H, LEU253G, LEU253H, LEU259G, LEU259H, LEU261G, LEU261H, LEU314G, LEU314H, LEU333G, LEU333H, LEU421G, LEU421H, LEU430G, LEU430H, LEU436G, LEU436H, LEU440G, LEU440H, LEU471G, LEU471H, LEU480G, LEU480H, LYS102G, LYS102H, LYS133G, LYS133H, LYS144G, LYS144H, LYS149G, LYS149H, LYS233G, LYS233H, LYS245G, LYS245H, LYS255G, LYS255H, LYS277G, LYS277H, LYS313G, LYS313H, LYS316G, LYS316H, LYS322G, LYS322H, LYS438G, LYS438H, LYS463G, LYS463H, LYS483G, LYS483H, LYS502G, LYS502H, LYS55G, LYS55H, LYS61G, MET140G, MET140H, MET247G, MET247H, MET426G, MET426H, PHE143G, PHE143H, PHE236G, PHE236H, PHE284G, PHE284H, PHE287G, PHE287H, PHE288G, PHE288H, PHE454G, PHE454H, PHE467G, PHE467H, PRO103G, PRO103H, PRO135G, PRO135H, PRO139G, PRO139H, PRO151G, PRO151H, PRO229G, PRO229H, PRO256G, PRO256H, PRO377G, PRO377H, PRO397G, PRO397H, PRO452G, PRO452H, PRO458G, PRO458H, PRO493G, PRO493H, PRO499G, PRO499H, PRO500G, PRO500H, SER137G, SER137H, SER145G, SER145H, SER239G, SER239H, SER240G, SER240H, SER244G, SER244H, SER258G, SER258H, SER423G, SER423H, SER427G, SER427H, SER437G, SER437H, SER453G, SER453H, SER465G, SER465H, SER481G, SER481H, SER490G, SER490H, SER501G, SER501H, SER59G, SER59H, THR142G, THR142H, THR242G, THR242H, THR248G, THR248H, THR249G, THR249H, THR282G, THR282H, THR289G, THR289H, THR486G, THR486H, THR489G, THR489H, TRP281G, TRP281H, TRP317G, TRP317H, TRP446G, TRP446H, TRP459G, TRP459H, TRP474G, TRP474H, TRP494G, TRP494H, TRP496G, TRP496H, TYR120G, TYR120H, TYR146G, TYR146H, TYR419H, TYR488G, TYR488H, TYR497G, TYR497H, VAL231G, VAL231H, VAL254G, VAL254H, VAL257G, VAL257H, VAL278G, VAL278H, VAL283G, VAL283H, VAL315G, VAL315H, VAL425G, VAL425H, VAL445G, VAL445H, VAL482G, VAL482H, VAL485G, VAL485H
• G-I: LYS502I, LYS61G
• G-J: ALA307J, ALA69G, ALA75G, ALA80G, ALA83G, ARG64G, ARG74G, ARG76G, ARG79G, ASP312J, ASP382J, CYS201G, GLU126G, GLU203G, GLU304J, GLU309J, GLU409J, GLU87G, GLY205G, HIS303J, ILE200G, ILE306J, ILE81G, LEU206G, LEU275J, LEU360J, LEU73G, LEU78G, LYS202G, LYS313J, LYS316J, LYS84G, LYS88G, PHE310J, PHE404J, PRO207G, SER305J, SER405J, SER70G, SER72G, THR358J, THR361J, THR381J, THR403J, THR406J, TRP66G, TYR77G, VAL204G, VAL308J, VAL311J, VAL315J
• H-L: ALA340L, ALA352H, ALA357H, ASN347L, ASP382H, CYS348L, GLN388L, GLU355H, GLU355L, GLU392L, GLY356H, ILE359H, LEU346L, LYS343L, LYS344L, LYS353H, LYS353L, MET387H, SER350L, SER351L, SER354H, SER354L, THR358H, THR381H, THR384H, VAL383H
• I-J: ALA107I, ALA107J, ALA109I, ALA109J, ALA116I, ALA116J, ALA134I, ALA134J, ALA241I, ALA241J, ALA250I, ALA250J, ALA251I, ALA251J, ALA279I, ALA279J, ALA318I, ALA318J, ALA424I, ALA424J, ALA439I, ALA439J, ALA442I, ALA442J, ALA450I, ALA450J, ALA457I, ALA457J, ALA68I, ALA68J, ARG332I, ARG332J, ARG435I, ARG435J, ARG464I, ARG464J, ARG469I, ARG469J, ARG487I, ARG487J, ARG60J, ASN290I, ASN290J, ASN320I, ASN320J, ASN412I, ASN415I, ASN415J, ASN428I, ASN428J, ASN448I, ASN448J, ASN62I, ASN62J, ASP110I, ASP113I, ASP141J, ASP230I, ASP230J, ASP232I, ASP232J, ASP274I, ASP274J, ASP276I, ASP276J, ASP312I, ASP312J, ASP491I, ASP491J, CYS286I, CYS286J, CYS331I, CYS331J, CYS433I, CYS433J, CYS449I, CYS449J, GLN132I, GLN132J, GLN252I, GLN252J, GLN441I, GLN441J, GLN451I, GLN451J, GLN456I, GLN456J, GLN484I, GLN484J, GLN498I, GLN498J, GLU105I, GLU105J, GLU106I, GLU106J, GLU150I, GLU150J, GLU280I, GLU280J, GLU319I, GLU319J, GLU407I, GLU408I, GLU408J, GLU409I, GLU431I, GLU431J, GLU434I, GLU434J, GLU470I, GLU470J, GLU473I, GLU473J, GLU477I, GLU477J, GLU492I, GLU492J, GLY153I, GLY153J, GLY243I, GLY243J, GLY285I, GLY285J, GLY291I, GLY291J, GLY330I, GLY330J, GLY422I, GLY422J, GLY443I, GLY443J, GLY460I, GLY460J, GLY461I, GLY461J, GLY466I, GLY466J, GLY468I, GLY468J, GLY472I, GLY472J, GLY495I, GLY495J, HIS418I, HIS418J, ILE136I, ILE136J, ILE147I, ILE147J, ILE152I, ILE152J, ILE234I, ILE234J, ILE246I, ILE246J, ILE293I, ILE293J, ILE321I, ILE321J, ILE411I, ILE411J, ILE444I, ILE444J, ILE447I, ILE447J, ILE455I, ILE455J, ILE462I, ILE462J, ILE58I, ILE58J, LEU104I, LEU104J, LEU108I, LEU108J, LEU138I, LEU138J, LEU148I, LEU148J, LEU253I, LEU253J, LEU259I, LEU259J, LEU261I, LEU261J, LEU314I, LEU314J, LEU333I, LEU333J, LEU421I, LEU421J, LEU430I, LEU430J, LEU436I, LEU436J, LEU440I, LEU440J, LEU471I, LEU471J, LEU480I, LEU480J, LYS102I, LYS102J, LYS133I, LYS133J, LYS144I, LYS144J, LYS149I, LYS149J, LYS233I, LYS233J, LYS245I, LYS245J, LYS255I, LYS255J, LYS277I, LYS277J, LYS313I, LYS313J, LYS316I, LYS316J, LYS322I, LYS322J, LYS438I, LYS438J, LYS463I, LYS463J, LYS483I, LYS483J, LYS502I, LYS502J, LYS55I, LYS55J, MET140I, MET140J, MET247I, MET247J, MET426I, MET426J, PHE143I, PHE143J, PHE236I, PHE236J, PHE284I, PHE284J, PHE287I, PHE287J, PHE288I, PHE288J, PHE454I, PHE454J, PHE467I, PHE467J, PRO103I, PRO103J, PRO135I, PRO135J, PRO139I, PRO139J, PRO151I, PRO151J, PRO229I, PRO229J, PRO256I, PRO256J, PRO377I, PRO377J, PRO397I, PRO452I, PRO452J, PRO458I, PRO458J, PRO493I, PRO493J, PRO499I, PRO499J, PRO500I, PRO500J, SER137I, SER137J, SER145I, SER145J, SER239I, SER239J, SER240I, SER240J, SER244I, SER244J, SER258I, SER258J, SER423I, SER423J, SER427I, SER427J, SER437I, SER437J, SER453I, SER453J, SER465I, SER465J, SER481I, SER481J, SER490I, SER490J, SER501I, SER501J, SER59I, SER59J, THR142I, THR142J, THR242I, THR242J, THR248I, THR248J, THR249I, THR249J, THR282I, THR282J, THR289I, THR289J, THR486I, THR486J, THR489I, THR489J, TRP170I, TRP281I, TRP281J, TRP317I, TRP317J, TRP446I, TRP446J, TRP459I, TRP459J, TRP474I, TRP474J, TRP494I, TRP494J, TRP496I, TRP496J, TYR120I, TYR120J, TYR146I, TYR146J, TYR419I, TYR419J, TYR488I, TYR488J, TYR497I, TYR497J, VAL231I, VAL231J, VAL254I, VAL254J, VAL257I, VAL257J, VAL278I, VAL278J, VAL283I, VAL283J, VAL315I, VAL315J, VAL425I, VAL425J, VAL445I, VAL445J, VAL482I, VAL482J, VAL485I, VAL485J
• K-L: ALA107K, ALA107L, ALA109K, ALA109L, ALA116K, ALA116L, ALA134K, ALA134L, ALA241K, ALA241L, ALA250K, ALA250L, ALA251K, ALA251L, ALA279K, ALA279L, ALA318K, ALA318L, ALA424K, ALA424L, ALA439K, ALA439L, ALA442K, ALA442L, ALA450K, ALA450L, ALA457K, ALA457L, ALA68K, ALA68L, ALA69K, ARG332K, ARG332L, ARG435K, ARG435L, ARG464K, ARG464L, ARG469K, ARG469L, ARG487K, ARG487L, ARG60L, ARG64K, ASN290K, ASN290L, ASN320K, ASN320L, ASN412K, ASN415K, ASN415L, ASN428K, ASN428L, ASN448K, ASN448L, ASN62K, ASP110K, ASP110L, ASP113K, ASP141K, ASP141L, ASP230K, ASP230L, ASP232K, ASP232L, ASP274K, ASP274L, ASP276K, ASP276L, ASP312K, ASP312L, ASP491K, ASP491L, CYS286K, CYS286L, CYS331K, CYS331L, CYS433K, CYS433L, CYS449K, CYS449L, GLN132K, GLN132L, GLN252K, GLN252L, GLN441K, GLN441L, GLN451K, GLN451L, GLN456K, GLN456L, GLN484K, GLN484L, GLN498K, GLN498L, GLU105K, GLU105L, GLU106K, GLU106L, GLU150K, GLU150L, GLU260K, GLU280K, GLU280L, GLU319K, GLU319L, GLU408K, GLU408L, GLU409K, GLU431K, GLU431L, GLU434K, GLU434L, GLU470K, GLU470L, GLU473K, GLU473L, GLU477K, GLU477L, GLU492K, GLU492L, GLY153K, GLY153L, GLY243K, GLY243L, GLY262K, GLY262L, GLY285K, GLY285L, GLY291K, GLY291L, GLY330K, GLY330L, GLY422K, GLY422L, GLY443K, GLY443L, GLY460K, GLY460L, GLY461K, GLY461L, GLY466K, GLY466L, GLY468K, GLY468L, GLY472K, GLY472L, GLY495K, GLY495L, HIS418K, HIS418L, HIS4K, HIS4L, ILE136K, ILE136L, ILE147K, ILE147L, ILE152K, ILE152L, ILE234K, ILE234L, ILE246K, ILE246L, ILE293K, ILE293L, ILE321K, ILE321L, ILE411K, ILE411L, ILE444K, ILE444L, ILE447K, ILE447L, ILE455K, ILE455L, ILE462K, ILE462L, ILE58K, ILE58L, LEU104K, LEU104L, LEU108K, LEU108L, LEU138K, LEU138L, LEU148K, LEU148L, LEU253K, LEU253L, LEU259K, LEU259L, LEU261K, LEU261L, LEU314K, LEU314L, LEU333K, LEU333L, LEU421K, LEU421L, LEU430K, LEU430L, LEU436K, LEU436L, LEU440K, LEU440L, LEU471K, LEU471L, LEU480K, LEU480L, LYS102K, LYS102L, LYS133K, LYS133L, LYS144K, LYS144L, LYS149K, LYS149L, LYS233K, LYS233L, LYS245K, LYS245L, LYS255K, LYS255L, LYS277K, LYS277L, LYS313K, LYS313L, LYS316K, LYS316L, LYS322K, LYS322L, LYS438K, LYS438L, LYS463K, LYS463L, LYS483K, LYS483L, LYS502K, LYS55K, LYS55L, LYS61L, MET140K, MET140L, MET247K, MET247L, MET426K, MET426L, PHE143K, PHE143L, PHE236K, PHE236L, PHE284K, PHE284L, PHE287K, PHE287L, PHE288K, PHE288L, PHE454K, PHE454L, PHE467K, PHE467L, PRO103K, PRO103L, PRO135K, PRO135L, PRO139K, PRO139L, PRO151K, PRO151L, PRO229K, PRO229L, PRO256K, PRO256L, PRO377K, PRO377L, PRO397K, PRO397L, PRO452K, PRO452L, PRO458K, PRO458L, PRO493K, PRO493L, PRO499K, PRO499L, PRO500K, PRO500L, SER137K, SER137L, SER145K, SER145L, SER239K, SER239L, SER240K, SER240L, SER244K, SER244L, SER258K, SER258L, SER423K, SER423L, SER427K, SER427L, SER437K, SER437L, SER453K, SER453L, SER465K, SER465L, SER481K, SER481L, SER490K, SER490L, SER501K, SER501L, SER59K, SER59L, SER70K, THR142K, THR142L, THR242L, THR248K, THR248L, THR249K, THR249L, THR282K, THR282L, THR289K, THR289L, THR486K, THR486L, THR489K, THR489L, TRP281K, TRP281L, TRP317K, TRP317L, TRP446K, TRP446L, TRP459K, TRP459L, TRP474K, TRP474L, TRP494K, TRP494L, TRP496K, TRP496L, TYR120K, TYR120L, TYR146K, TYR146L, TYR419K, TYR419L, TYR488K, TYR488L, TYR497K, TYR497L, VAL231K, VAL231L, VAL254K, VAL254L, VAL257K, VAL257L, VAL278K, VAL278L, VAL283K, VAL283L, VAL315K, VAL315L, VAL425K, VAL425L, VAL445K, VAL445L, VAL482K, VAL482L, VAL485K, VAL485L