3ISW

crystal structure of filamin-a immunoglobulin-like repeat 21 bound to an n-terminal peptide of cftr

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 59
  • Norm. En. per Res.: -5.1731
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-15.1654	-11.7786	-43.0872	-70.0312	39	1	0	1916	4	15	22
A-C	-101.9732	-0.986	-202.251	-305.2103	59	15	8	6916	0	7	4
B-C	-44.4977	-1.9084	-133.027	-179.4331	46	6	2	4825	0	4	1

Interface residues

• A-B: ALA2268A, ALA2272A, ALA2272B, ALA2274B, ALA2281B, ARG2264A, ARG2288A, ASN2312A, ASN2312B, ASP2287A, ASP2290A, GLU2276B, GLU2282B, GLU2286A, GLU2313A, GLU2313B, GLU2314A, GLU2314B, GLY2269A, GLY2270A, GLY2277B, GLY2291A, HIS2315B, ILE2273A, ILE2273B, ILE2283A, ILE2283B, LEU2271A, LYS2280B, LYS2289A, LYS2310A, LYS2310B, PHE2285A, PHE2311A, SER2279B, SER2284A, SER2292A, SER2308B, VAL2275B
• A-C: ALA21C, ALA2266A, ALA2268A, ALA2272A, ALA2274A, ALA2281A, ALA2296A, ALA9C, ARG2264A, ASN2312A, ASP2287A, ASP2304A, CYS2293A, GLU2265A, GLU2276A, GLU2282A, GLU2286A, GLU2301A, GLU2306A, GLU2313A, GLY2267A, GLY2269A, GLY2270A, GLY2277A, GLY2294A, ILE2261A, ILE2273A, ILE2283A, LEU15C, LEU2271A, LYS14C, LYS2280A, LYS2310A, LYS8C, PHE16C, PHE17C, PHE2285A, PHE2311A, PRO2278A, PRO22C, SER10C, SER13C, SER18C, SER2279A, SER2284A, SER2308A, THR20C, THR2263A, TRP19C, TRP2262A, TYR2297A, TYR2305A, VAL11C, VAL12C, VAL2241A, VAL2275A, VAL2295A, VAL2299A, VAL2307A
• B-C: ALA21C, ALA2272B, ALA2274B, ALA2281B, ASN2312B, ASP2287B, ASP2304B, CYS2293B, GLU2276B, GLU2282B, GLU2286B, GLU2301B, GLU2306B, GLU2313B, GLY2269B, GLY2270B, GLY2277B, HIS2315B, ILE2261B, ILE2273B, ILE2283B, LEU15C, LEU2271B, LYS14C, LYS2280B, LYS2310B, PHE16C, PHE17C, PHE2285B, PHE2311B, PRO2278B, PRO22C, PRO2320B, SER18C, SER2279B, SER2284B, SER2308B, THR20C, TRP19C, TYR2297B, TYR2305B, VAL2275B, VAL2295B, VAL2299B, VAL2307B, VAL2309B