3IQF

structure of f420 dependent methylene-tetrahydromethanopterin dehydrogenase in complex with methenyl-tetrahydromethanopterin

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 269
  • Norm. En. per Res.: -5.632
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-2.5651	5.4673	-95.0997	-92.1975	37	3	1	3613	2	14	22
A-C	-8.5602	4.0681	-98.8017	-103.2937	37	4	1	3638	2	14	22
A-D	-199.4631	-380.6675	-934.865	-1514.9956	269	54	22	37101	34	169	180
A-E	-77.2505	-151.2403	-332.134	-560.6249	122	17	3	14649	19	61	71
A-G	0.0	32.4217	-9.648	22.7737	18	0	0	595	0	17	32
A-I	0.0	0.0	-0.123	-0.123	5	0	0	11	0	3	6
A-K	0.0	2.7065	-0.2137	2.4928	11	0	0	66	0	12	14
B-C	-3.5835	4.7962	-98.9982	-97.7855	37	4	1	3574	2	14	21
B-D	-77.2965	-158.9893	-321.26	-557.5458	123	15	3	14695	18	61	69
B-F	-212.5653	-374.7476	-920.039	-1507.3519	271	48	22	36922	26	170	181
B-I	-18.0206	18.1193	-15.6183	-15.5196	20	5	0	640	0	22	29
C-E	-218.2027	-394.4402	-907.048	-1519.6909	272	43	22	36596	32	168	182
C-F	-91.2074	-165.5114	-304.703	-561.4218	123	24	3	14640	17	59	72
C-H	0.0	29.4253	-2.3247	27.1006	18	0	0	301	0	23	22
C-I	0.0	35.1069	-17.8207	17.2862	27	0	0	1018	1	34	36
C-L	0.0	0.0	-0.2659	-0.2659	8	0	0	69	0	14	15
D-E	0.0	5.9517	-99.1092	-93.1575	37	3	1	3583	2	15	22
D-F	-2.7035	4.4414	-94.0966	-92.3587	37	4	1	3564	2	15	23
E-F	0.0	4.2616	-97.1187	-92.8571	37	4	1	3575	2	14	22
E-G	0.0	0.0	-0.0013	-0.0013	2	0	0	3	0	7	9
E-H	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	0	1
E-I	0.0	0.0	-0.0013	-0.0013	2	0	0	3	0	3	2
F-I	-26.662	-21.5496	10.0243	-38.1873	8	3	0	183	1	11	14
G-H	0.0	5.6505	-97.8456	-92.1951	37	3	1	3574	2	14	22
G-I	-3.1837	5.0203	-100.643	-98.8064	37	3	1	3577	2	14	21
G-J	-205.4592	-395.8293	-896.976	-1498.2645	269	57	22	37036	31	173	180
G-K	-91.1662	-120.7283	-337.041	-548.9355	122	16	3	14696	18	60	70
H-I	-2.9069	7.1792	-98.1416	-93.8693	37	3	1	3550	2	14	21
H-J	-86.5526	-162.2241	-330.962	-579.7387	121	17	3	14710	18	59	70
H-L	-212.0686	-385.2276	-919.462	-1516.7582	272	48	22	36750	29	168	182
I-K	-216.9513	-387.8134	-911.751	-1516.5157	271	48	22	36737	31	170	181
I-L	-68.8133	-157.5275	-321.936	-548.2769	122	16	3	14539	17	59	70
J-K	-3.8	6.6088	-95.182	-92.3732	37	4	1	3544	2	14	20
J-L	-3.1988	5.2449	-99.3768	-97.3306	37	5	1	3634	2	14	22
K-L	-5.4894	4.8309	-100.652	-101.3105	37	4	1	3594	2	15	22

Interface residues

• A-B: ALA199B, ALA260A, ARG252A, ARG263A, ARG276A, ASN196B, ASN258A, ASN258B, ASP249A, ASP259A, GLU195B, GLU250B, GLU253A, GLU253B, GLU255A, GLU255B, GLU280A, LEU189B, LEU247B, LEU254A, LEU254B, LEU262A, LYS202B, LYS256A, LYS256B, LYS275A, LYS277A, MET200B, MET204B, MET279A, PHE278A, PRO197B, SER257A, SER257B, TYR198B, VAL201B, VAL261A
• A-C: ALA199A, ALA260C, ARG252C, ARG263C, ARG276C, ASN196A, ASN258A, ASN258C, ASP249C, ASP259C, GLU195A, GLU250A, GLU253A, GLU253C, GLU255A, GLU255C, GLU280C, LEU189A, LEU247A, LEU254A, LEU254C, LEU262C, LYS202A, LYS256A, LYS256C, LYS275C, LYS277C, MET200A, MET204A, MET279C, PHE278C, PRO197A, SER257A, SER257C, TYR198A, VAL201A, VAL261C
• A-D: ALA127A, ALA127D, ALA138A, ALA138D, ALA142A, ALA142D, ALA149A, ALA149D, ALA150A, ALA150D, ALA235A, ALA235D, ALA245A, ALA245D, ALA248A, ALA248D, ALA267A, ALA267D, ALA28A, ALA28D, ALA51A, ALA51D, ALA52A, ALA52D, ALA56A, ALA56D, ALA6A, ALA6D, ARG128A, ARG128D, ARG129A, ARG129D, ARG155A, ARG155D, ARG229A, ARG229D, ARG242A, ARG242D, ARG252A, ARG252D, ARG263A, ARG263D, ARG27A, ARG27D, ARG30A, ARG30D, ARG36A, ARG36D, ASN13A, ASN13D, ASN141A, ASN141D, ASP133A, ASP133D, ASP143A, ASP143D, ASP162A, ASP162D, ASP21A, ASP21D, ASP226A, ASP226D, ASP249A, ASP249D, ASP25A, ASP25D, ASP269A, ASP269D, ASP281A, ASP281D, ASP29A, ASP29D, ASP32A, ASP32D, ASP45A, ASP45D, ASP58A, ASP58D, ASP62A, CYS11A, CYS11D, CYS221A, CYS221D, CYS48A, CYS48D, GLN158A, GLN158D, GLU130A, GLU130D, GLU136A, GLU136D, GLU159A, GLU159D, GLU193A, GLU193D, GLU228A, GLU228D, GLU239A, GLU239D, GLU246A, GLU246D, GLU250A, GLU250D, GLU253A, GLU253D, GLU26A, GLU26D, GLU280A, GLU280D, GLU283A, GLU283D, GLU31A, GLU31D, GLU34A, GLU34D, GLU47A, GLU47D, GLU50A, GLU50D, GLY126A, GLY126D, GLY12A, GLY12D, GLY152A, GLY152D, GLY15A, GLY15D, GLY270A, GLY270D, GLY39A, GLY39D, HIS238A, HIS238D, HIS266A, HIS266D, ILE139A, ILE139D, ILE233A, ILE233D, ILE59A, ILE59D, ILE7A, ILE7D, ILE9A, ILE9D, LEU125A, LEU125D, LEU132A, LEU132D, LEU144A, LEU144D, LEU148A, LEU148D, LEU14A, LEU14D, LEU23A, LEU23D, LEU24A, LEU24D, LEU262A, LEU262D, LEU273A, LEU273D, LYS10A, LYS10D, LYS146A, LYS146D, LYS227A, LYS227D, LYS243A, LYS243D, LYS256A, LYS256D, LYS271A, LYS271D, LYS275A, LYS275D, LYS277A, LYS277D, LYS43A, LYS43D, MET137A, MET137D, MET145A, MET145D, MET18A, MET18D, MET19A, MET19D, MET20A, MET20D, MET22A, MET22D, MET279A, MET279D, MET44A, MET44D, MET55A, MET55D, PHE131A, PHE131D, PHE154A, PHE154D, PHE194A, PHE194D, PHE278A, PHE278D, PHE35A, PHE35D, PHE63A, PHE63D, PHE8A, PHE8D, PRO134A, PRO134D, PRO232A, PRO232D, PRO265A, PRO265D, PRO268A, PRO268D, PRO282A, PRO282D, SER17A, SER17D, SER236A, SER236D, SER274A, SER274D, SER41A, SER41D, THR151A, THR151D, THR264A, THR264D, THR40A, THR40D, TYR140A, TYR140D, TYR230A, TYR230D, VAL135A, VAL135D, VAL147A, VAL147D, VAL153A, VAL153D, VAL156A, VAL156D, VAL231A, VAL231D, VAL234A, VAL234D, VAL261A, VAL261D, VAL272A, VAL272D, VAL33A, VAL33D, VAL37A, VAL37D, VAL38A, VAL38D, VAL3A, VAL3D, VAL42A, VAL42D, VAL49A, VAL49D
• A-E: ALA199A, ALA199E, ALA203A, ALA203E, ALA205A, ALA205E, ALA206A, ALA206E, ALA210A, ALA210E, ALA214E, ALA235A, ALA235E, ALA237A, ALA237E, ALA244A, ALA244E, ALA245A, ALA245E, ALA248A, ALA248E, ALA251E, ARG185A, ARG185E, ARG191A, ARG191E, ARG229A, ARG229E, ARG242A, ARG242E, ASN186A, ASN186E, ASN212A, ASN212E, ASP184A, ASP184E, ASP215A, ASP215E, ASP226A, ASP226E, ASP249A, ASP249E, GLU130A, GLU136A, GLU136E, GLU190A, GLU190E, GLU208A, GLU208E, GLU211A, GLU211E, GLU219A, GLU219E, GLU224A, GLU224E, GLU228A, GLU228E, GLU239A, GLU239E, GLU246A, GLU246E, GLU250A, GLU250E, GLY220A, GLY220E, HIS238A, HIS238E, ILE209A, ILE209E, ILE233A, ILE233E, LEU188A, LEU188E, LEU189A, LEU189E, LEU207A, LEU207E, LEU247A, LEU247E, LEU254A, LEU254E, LYS202A, LYS202E, LYS227A, LYS227E, LYS243A, LYS243E, MET200A, MET200E, MET204A, MET204E, MET240A, MET240E, MET241A, MET241E, PHE131A, PHE131E, PRO197A, PRO197E, PRO232A, PRO232E, SER217A, SER217E, SER236A, SER236E, THR187A, THR187E, TYR198A, TYR198E, TYR230A, TYR230E, VAL201A, VAL201E, VAL213A, VAL213E, VAL216A, VAL216E, VAL223E, VAL231A, VAL231E, VAL234A, VAL234E
• A-G: ASN176A, ASN176G, ASP171A, ASP171G, ASP177A, ASP177G, GLU166G, GLU170A, GLU170G, GLU172A, GLU172G, GLU192A, GLU192G, LYS167A, LYS167G, LYS169A, SER174A, SER174G
• A-I: ASN258A, ASP281I, GLU195A, GLU283I, LYS277A
• A-K: ALA260A, ARG276A, ASP226K, GLN225K, GLU192A, GLU195A, GLU228K, GLU280A, GLU283A, LYS227K, LYS277A
• B-C: ALA199C, ALA260B, ARG252B, ARG263B, ARG276B, ASN196C, ASN258B, ASN258C, ASP249B, ASP259B, GLU195C, GLU250C, GLU253B, GLU253C, GLU255B, GLU255C, GLU280B, LEU189C, LEU247C, LEU254B, LEU254C, LEU262B, LYS202C, LYS256B, LYS256C, LYS275B, LYS277B, MET200C, MET204C, MET279B, PHE278B, PRO197C, SER257B, SER257C, TYR198C, VAL201C, VAL261B
• B-D: ALA199B, ALA199D, ALA203B, ALA203D, ALA205B, ALA205D, ALA206B, ALA206D, ALA210B, ALA210D, ALA214B, ALA214D, ALA235B, ALA235D, ALA237B, ALA237D, ALA244B, ALA244D, ALA245B, ALA245D, ALA248B, ALA248D, ALA251B, ALA251D, ARG185B, ARG185D, ARG191B, ARG191D, ARG229B, ARG229D, ARG242B, ARG242D, ASN186B, ASN186D, ASN212B, ASN212D, ASP184B, ASP184D, ASP215B, ASP215D, ASP226B, ASP226D, ASP249B, ASP249D, GLU130B, GLU136B, GLU136D, GLU190B, GLU190D, GLU208B, GLU208D, GLU211B, GLU211D, GLU219B, GLU219D, GLU224B, GLU224D, GLU228B, GLU228D, GLU239B, GLU239D, GLU246B, GLU246D, GLU250B, GLU250D, GLY220B, GLY220D, HIS238B, HIS238D, ILE209B, ILE209D, ILE233B, ILE233D, LEU188B, LEU188D, LEU189B, LEU189D, LEU207B, LEU207D, LEU247B, LEU247D, LEU254B, LEU254D, LYS202B, LYS202D, LYS227B, LYS227D, LYS243B, LYS243D, MET200B, MET200D, MET204B, MET204D, MET240B, MET240D, MET241B, MET241D, PHE131B, PHE131D, PRO197B, PRO197D, PRO232B, PRO232D, SER217B, SER217D, SER236B, SER236D, THR187B, THR187D, TYR198B, TYR198D, TYR230B, TYR230D, VAL201B, VAL201D, VAL213B, VAL213D, VAL216B, VAL216D, VAL231B, VAL231D, VAL234B, VAL234D
• B-F: ALA127B, ALA127F, ALA138B, ALA138F, ALA142B, ALA142F, ALA149B, ALA149F, ALA150B, ALA150F, ALA235B, ALA235F, ALA245B, ALA245F, ALA248B, ALA248F, ALA267B, ALA267F, ALA28B, ALA28F, ALA51B, ALA51F, ALA52B, ALA52F, ALA56B, ALA56F, ALA6B, ALA6F, ARG128B, ARG128F, ARG129B, ARG129F, ARG155B, ARG155F, ARG229B, ARG229F, ARG242B, ARG242F, ARG252B, ARG252F, ARG263B, ARG263F, ARG27B, ARG27F, ARG30B, ARG30F, ARG36B, ARG36F, ASN13B, ASN13F, ASN141B, ASN141F, ASP133B, ASP133F, ASP143B, ASP143F, ASP162B, ASP162F, ASP21B, ASP21F, ASP226B, ASP226F, ASP249B, ASP249F, ASP25B, ASP25F, ASP269B, ASP269F, ASP281B, ASP281F, ASP29B, ASP29F, ASP32B, ASP32F, ASP45B, ASP45F, ASP58B, ASP58F, ASP62F, CYS11B, CYS11F, CYS221B, CYS221F, CYS48B, CYS48F, GLN158B, GLN158F, GLU130B, GLU130F, GLU136B, GLU136F, GLU159B, GLU159F, GLU193B, GLU193F, GLU228B, GLU228F, GLU239B, GLU239F, GLU246B, GLU246F, GLU250B, GLU250F, GLU253B, GLU253F, GLU26B, GLU26F, GLU280B, GLU280F, GLU283B, GLU283F, GLU31B, GLU31F, GLU34B, GLU34F, GLU47B, GLU47F, GLU50B, GLU50F, GLU54B, GLU54F, GLY126B, GLY126F, GLY12B, GLY12F, GLY152B, GLY152F, GLY15B, GLY15F, GLY270B, GLY270F, GLY39B, GLY39F, HIS238B, HIS238F, HIS266B, HIS266F, ILE139B, ILE139F, ILE233B, ILE233F, ILE59B, ILE59F, ILE7B, ILE7F, ILE9B, ILE9F, LEU125B, LEU125F, LEU132B, LEU132F, LEU144B, LEU144F, LEU148B, LEU148F, LEU14B, LEU14F, LEU23B, LEU23F, LEU24B, LEU24F, LEU262B, LEU262F, LEU273B, LEU273F, LYS10B, LYS10F, LYS146B, LYS146F, LYS227B, LYS227F, LYS243B, LYS243F, LYS256B, LYS256F, LYS271B, LYS271F, LYS275B, LYS275F, LYS277B, LYS277F, LYS43B, LYS43F, MET137B, MET137F, MET145B, MET145F, MET18B, MET18F, MET19B, MET19F, MET20B, MET20F, MET22B, MET22F, MET279B, MET279F, MET44B, MET44F, MET55B, MET55F, PHE131B, PHE131F, PHE154B, PHE154F, PHE194B, PHE194F, PHE278B, PHE278F, PHE35B, PHE35F, PHE63B, PHE63F, PHE8B, PHE8F, PRO134B, PRO134F, PRO232B, PRO232F, PRO265B, PRO265F, PRO268B, PRO268F, PRO282B, PRO282F, SER17B, SER17F, SER236B, SER236F, SER274B, SER274F, SER41B, SER41F, THR151B, THR151F, THR264B, THR264F, THR40B, THR40F, TYR140B, TYR140F, TYR230B, TYR230F, VAL135B, VAL135F, VAL147B, VAL147F, VAL153B, VAL153F, VAL156B, VAL156F, VAL231B, VAL231F, VAL234B, VAL234F, VAL261B, VAL261F, VAL272B, VAL272F, VAL33B, VAL33F, VAL37B, VAL37F, VAL38B, VAL38F, VAL3B, VAL3F, VAL42B, VAL42F, VAL49B, VAL49F
• B-I: ALA267I, ARG276B, ASP259B, ASP269I, ASP281B, GLU166I, GLU170I, GLU280B, GLU283B, GLU283I, GLY270I, LEU273I, LYS169I, LYS271I, LYS277B, MET279B, PRO268I, PRO282B, THR2I, VAL3I
• C-E: ALA127C, ALA127E, ALA138C, ALA138E, ALA142C, ALA142E, ALA149C, ALA149E, ALA150C, ALA150E, ALA235C, ALA235E, ALA245C, ALA245E, ALA248C, ALA248E, ALA267C, ALA267E, ALA28C, ALA28E, ALA51C, ALA51E, ALA52C, ALA52E, ALA56C, ALA56E, ALA6C, ALA6E, ARG128C, ARG128E, ARG129C, ARG129E, ARG155C, ARG155E, ARG229C, ARG229E, ARG242C, ARG242E, ARG252C, ARG252E, ARG263C, ARG263E, ARG27C, ARG27E, ARG30C, ARG30E, ARG36C, ARG36E, ASN13C, ASN13E, ASN141C, ASN141E, ASP133C, ASP133E, ASP143C, ASP143E, ASP162C, ASP162E, ASP21C, ASP21E, ASP226C, ASP226E, ASP249C, ASP249E, ASP25C, ASP25E, ASP269C, ASP269E, ASP281C, ASP281E, ASP29C, ASP29E, ASP32C, ASP32E, ASP45C, ASP45E, ASP58C, ASP58E, ASP62C, ASP62E, CYS11C, CYS11E, CYS221C, CYS221E, CYS48C, CYS48E, GLN158C, GLN158E, GLU130C, GLU130E, GLU136C, GLU136E, GLU159C, GLU159E, GLU193C, GLU193E, GLU228C, GLU228E, GLU239C, GLU239E, GLU246C, GLU246E, GLU250C, GLU250E, GLU253C, GLU253E, GLU26C, GLU26E, GLU280C, GLU280E, GLU283C, GLU283E, GLU31C, GLU31E, GLU34C, GLU34E, GLU47C, GLU47E, GLU50C, GLU50E, GLU54C, GLU54E, GLY126C, GLY126E, GLY12C, GLY12E, GLY152C, GLY152E, GLY15C, GLY15E, GLY270C, GLY270E, GLY39C, GLY39E, HIS238C, HIS238E, HIS266C, HIS266E, ILE139C, ILE139E, ILE233C, ILE233E, ILE59C, ILE59E, ILE7C, ILE7E, ILE9C, ILE9E, LEU125C, LEU125E, LEU132C, LEU132E, LEU144C, LEU144E, LEU148C, LEU148E, LEU14C, LEU14E, LEU23C, LEU23E, LEU24C, LEU24E, LEU262C, LEU262E, LEU273C, LEU273E, LYS10C, LYS10E, LYS146C, LYS146E, LYS227C, LYS227E, LYS243C, LYS243E, LYS256C, LYS256E, LYS271C, LYS271E, LYS275C, LYS275E, LYS277C, LYS277E, LYS43C, LYS43E, MET137C, MET137E, MET145C, MET145E, MET18C, MET18E, MET19C, MET19E, MET20C, MET20E, MET22C, MET22E, MET279C, MET279E, MET44C, MET44E, MET55C, MET55E, PHE131C, PHE131E, PHE154C, PHE154E, PHE194C, PHE194E, PHE278C, PHE278E, PHE35C, PHE35E, PHE63C, PHE63E, PHE8C, PHE8E, PRO134C, PRO134E, PRO232C, PRO232E, PRO265C, PRO265E, PRO268C, PRO268E, PRO282C, PRO282E, SER17C, SER17E, SER236C, SER236E, SER274C, SER274E, SER41C, SER41E, THR151C, THR151E, THR264C, THR264E, THR40C, THR40E, TYR140C, TYR140E, TYR230C, TYR230E, VAL135C, VAL135E, VAL147C, VAL147E, VAL153C, VAL153E, VAL156C, VAL156E, VAL231C, VAL231E, VAL234C, VAL234E, VAL261C, VAL261E, VAL272C, VAL272E, VAL33C, VAL33E, VAL37C, VAL37E, VAL38C, VAL38E, VAL3C, VAL3E, VAL42C, VAL42E, VAL49C, VAL49E
• C-F: ALA199C, ALA199F, ALA203C, ALA203F, ALA205C, ALA205F, ALA206C, ALA206F, ALA210C, ALA210F, ALA214C, ALA214F, ALA235C, ALA235F, ALA237C, ALA237F, ALA244C, ALA244F, ALA245C, ALA245F, ALA248C, ALA248F, ALA251C, ALA251F, ARG185C, ARG185F, ARG191C, ARG191F, ARG229C, ARG229F, ARG242C, ARG242F, ASN186C, ASN186F, ASN212C, ASN212F, ASP184C, ASP184F, ASP215C, ASP215F, ASP226C, ASP226F, ASP249C, ASP249F, GLU130C, GLU136C, GLU136F, GLU190C, GLU190F, GLU208C, GLU208F, GLU211C, GLU211F, GLU219C, GLU219F, GLU224C, GLU224F, GLU228C, GLU228F, GLU239C, GLU239F, GLU246C, GLU246F, GLU250C, GLU250F, GLY220C, GLY220F, HIS238C, HIS238F, ILE209C, ILE209F, ILE233C, ILE233F, LEU188C, LEU188F, LEU189C, LEU189F, LEU207C, LEU207F, LEU247C, LEU247F, LEU254C, LEU254F, LYS202C, LYS202F, LYS227C, LYS227F, LYS243C, LYS243F, MET200C, MET200F, MET204C, MET204F, MET240C, MET240F, MET241C, MET241F, PHE131C, PHE131F, PRO197C, PRO197F, PRO232C, PRO232F, SER217C, SER217F, SER236C, SER236F, THR187C, THR187F, TYR198C, TYR198F, TYR230C, TYR230F, VAL201C, VAL201F, VAL213C, VAL213F, VAL216C, VAL216F, VAL231C, VAL231F, VAL234C, VAL234F
• C-H: ALA267C, ASP259H, ASP269C, ASP281H, ASP32C, GLU280H, GLU283C, GLU283H, GLU31C, LEU273C, LYS169C, LYS271C, LYS275H, LYS277H, MET279H, PRO268C, PRO282C, THR2C
• C-I: ALA260C, ALA260I, ARG276I, ASN196I, ASN258C, ASN258I, ASP259C, ASP281C, ASP281I, GLU192I, GLU195C, GLU195I, GLU280C, GLU280I, GLU283C, GLU283I, LYS271C, LYS271I, LYS275I, LYS277C, LYS277I, MET279C, PRO197C, PRO197I, PRO282I, SER274C, SER274I
• C-L: ASP269C, GLU166C, GLU170C, GLU228L, LYS169C, LYS227L, LYS271C, THR2C
• D-E: ALA199E, ALA260D, ARG252D, ARG263D, ARG276D, ASN196E, ASN258D, ASN258E, ASP249D, ASP259D, GLU195E, GLU250E, GLU253D, GLU253E, GLU255D, GLU255E, GLU280D, LEU189E, LEU247E, LEU254D, LEU254E, LEU262D, LYS202E, LYS256D, LYS256E, LYS275D, LYS277D, MET200E, MET204E, MET279D, PHE278D, PRO197E, SER257D, SER257E, TYR198E, VAL201E, VAL261D
• D-F: ALA199D, ALA260F, ARG252F, ARG263F, ARG276F, ASN196D, ASN258D, ASN258F, ASP249F, ASP259F, GLU195D, GLU250D, GLU253D, GLU253F, GLU255D, GLU255F, GLU280F, LEU189D, LEU247D, LEU254D, LEU254F, LEU262F, LYS202D, LYS256D, LYS256F, LYS275F, LYS277F, MET200D, MET204D, MET279F, PHE278F, PRO197D, SER257D, SER257F, TYR198D, VAL201D, VAL261F
• E-F: ALA199F, ALA260E, ARG252E, ARG263E, ARG276E, ASN196F, ASN258E, ASN258F, ASP249E, ASP259E, GLU195F, GLU250F, GLU253E, GLU253F, GLU255E, GLU255F, GLU280E, LEU189F, LEU247F, LEU254E, LEU254F, LEU262E, LYS202F, LYS256E, LYS256F, LYS275E, LYS277E, MET200F, MET204F, MET279E, PHE278E, PRO197F, SER257E, SER257F, TYR198F, VAL201F, VAL261E
• E-G: ASP226E, LYS277G
• E-H: ARG129E, LYS277H
• E-I: LYS227E, LYS277I
• F-I: ASP171I, GLU166I, GLU170I, GLU172I, GLU228F, LYS167I, LYS169I, LYS227F
• G-H: ALA199H, ALA260G, ARG252G, ARG263G, ARG276G, ASN196H, ASN258G, ASN258H, ASP249G, ASP259G, GLU195H, GLU250H, GLU253G, GLU253H, GLU255G, GLU255H, GLU280G, LEU189H, LEU247H, LEU254G, LEU254H, LEU262G, LYS202H, LYS256G, LYS256H, LYS275G, LYS277G, MET200H, MET204H, MET279G, PHE278G, PRO197H, SER257G, SER257H, TYR198H, VAL201H, VAL261G
• G-I: ALA199G, ALA260I, ARG252I, ARG263I, ARG276I, ASN196G, ASN258G, ASN258I, ASP249I, ASP259I, GLU195G, GLU250G, GLU253G, GLU253I, GLU255G, GLU255I, GLU280I, LEU189G, LEU247G, LEU254G, LEU254I, LEU262I, LYS202G, LYS256G, LYS256I, LYS275I, LYS277I, MET200G, MET204G, MET279I, PHE278I, PRO197G, SER257G, SER257I, TYR198G, VAL201G, VAL261I
• G-J: ALA127G, ALA127J, ALA138G, ALA138J, ALA142G, ALA142J, ALA149G, ALA149J, ALA150G, ALA150J, ALA235G, ALA235J, ALA245G, ALA245J, ALA248G, ALA248J, ALA267G, ALA267J, ALA28G, ALA28J, ALA51G, ALA51J, ALA52G, ALA52J, ALA56G, ALA56J, ALA6G, ALA6J, ARG128G, ARG128J, ARG129G, ARG129J, ARG155G, ARG155J, ARG229G, ARG229J, ARG242G, ARG242J, ARG252G, ARG252J, ARG263G, ARG263J, ARG27G, ARG27J, ARG30G, ARG30J, ARG36G, ARG36J, ASN13G, ASN13J, ASN141G, ASN141J, ASP133G, ASP133J, ASP143G, ASP143J, ASP162G, ASP162J, ASP21G, ASP21J, ASP226G, ASP226J, ASP249G, ASP249J, ASP25G, ASP25J, ASP269G, ASP269J, ASP281G, ASP281J, ASP29G, ASP29J, ASP32G, ASP32J, ASP45G, ASP45J, ASP58G, ASP58J, ASP62J, CYS11G, CYS11J, CYS221G, CYS221J, CYS48G, CYS48J, GLN158G, GLN158J, GLU130G, GLU130J, GLU136G, GLU136J, GLU159G, GLU159J, GLU193G, GLU193J, GLU228G, GLU228J, GLU239G, GLU239J, GLU246G, GLU246J, GLU250G, GLU250J, GLU253G, GLU253J, GLU26G, GLU26J, GLU280G, GLU280J, GLU283G, GLU283J, GLU31G, GLU31J, GLU34G, GLU34J, GLU47G, GLU47J, GLU50G, GLU50J, GLY126G, GLY126J, GLY12G, GLY12J, GLY152G, GLY152J, GLY15G, GLY15J, GLY270G, GLY270J, GLY39G, GLY39J, HIS238G, HIS238J, HIS266G, HIS266J, ILE139G, ILE139J, ILE233G, ILE233J, ILE59G, ILE59J, ILE7G, ILE7J, ILE9G, ILE9J, LEU125G, LEU125J, LEU132G, LEU132J, LEU144G, LEU144J, LEU148G, LEU148J, LEU14G, LEU14J, LEU23G, LEU23J, LEU24G, LEU24J, LEU262G, LEU262J, LEU273G, LEU273J, LYS10G, LYS10J, LYS146G, LYS146J, LYS227G, LYS227J, LYS243G, LYS243J, LYS256G, LYS256J, LYS271G, LYS271J, LYS275G, LYS275J, LYS277G, LYS277J, LYS43G, LYS43J, MET137G, MET137J, MET145G, MET145J, MET18G, MET18J, MET19G, MET19J, MET20G, MET20J, MET22G, MET22J, MET279G, MET279J, MET44G, MET44J, MET55G, MET55J, PHE131G, PHE131J, PHE154G, PHE154J, PHE194G, PHE194J, PHE278G, PHE278J, PHE35G, PHE35J, PHE63G, PHE63J, PHE8G, PHE8J, PRO134G, PRO134J, PRO232G, PRO232J, PRO265G, PRO265J, PRO268G, PRO268J, PRO282G, PRO282J, SER17G, SER17J, SER236G, SER236J, SER274G, SER274J, SER41G, SER41J, THR151G, THR151J, THR264G, THR264J, THR40G, THR40J, TYR140G, TYR140J, TYR230G, TYR230J, VAL135G, VAL135J, VAL147G, VAL147J, VAL153G, VAL153J, VAL156G, VAL156J, VAL231G, VAL231J, VAL234G, VAL234J, VAL261G, VAL261J, VAL272G, VAL272J, VAL33G, VAL33J, VAL37G, VAL37J, VAL38G, VAL38J, VAL3G, VAL3J, VAL42G, VAL42J, VAL49G, VAL49J
• G-K: ALA199G, ALA199K, ALA203G, ALA203K, ALA205G, ALA205K, ALA206G, ALA206K, ALA210G, ALA210K, ALA235G, ALA235K, ALA237G, ALA237K, ALA244G, ALA244K, ALA245G, ALA245K, ALA248G, ALA248K, ALA251G, ALA251K, ARG185G, ARG185K, ARG191G, ARG191K, ARG229G, ARG229K, ARG242G, ARG242K, ASN186G, ASN186K, ASN212G, ASN212K, ASP184G, ASP184K, ASP215G, ASP215K, ASP226G, ASP226K, ASP249G, ASP249K, GLU130K, GLU136G, GLU136K, GLU190G, GLU190K, GLU208G, GLU208K, GLU211G, GLU211K, GLU219G, GLU219K, GLU224G, GLU224K, GLU228G, GLU228K, GLU239G, GLU239K, GLU246G, GLU246K, GLU250G, GLU250K, GLY220G, GLY220K, HIS238G, HIS238K, ILE209G, ILE209K, ILE233G, ILE233K, LEU188G, LEU188K, LEU189G, LEU189K, LEU207G, LEU207K, LEU247G, LEU247K, LEU254G, LEU254K, LYS202G, LYS202K, LYS227G, LYS227K, LYS243G, LYS243K, MET200G, MET200K, MET204G, MET204K, MET240G, MET240K, MET241G, MET241K, PHE131G, PHE131K, PRO197G, PRO197K, PRO232G, PRO232K, SER217G, SER217K, SER236G, SER236K, THR187G, THR187K, TYR198G, TYR198K, TYR230G, TYR230K, VAL201G, VAL201K, VAL213G, VAL213K, VAL216G, VAL216K, VAL223K, VAL231G, VAL231K, VAL234G, VAL234K
• H-I: ALA199I, ALA260H, ARG252H, ARG263H, ARG276H, ASN196I, ASN258H, ASN258I, ASP249H, ASP259H, GLU195I, GLU250I, GLU253H, GLU253I, GLU255H, GLU255I, GLU280H, LEU189I, LEU247I, LEU254H, LEU254I, LEU262H, LYS202I, LYS256H, LYS256I, LYS275H, LYS277H, MET200I, MET204I, MET279H, PHE278H, PRO197I, SER257H, SER257I, TYR198I, VAL201I, VAL261H
• H-J: ALA199H, ALA199J, ALA203H, ALA203J, ALA205H, ALA205J, ALA206H, ALA206J, ALA210H, ALA210J, ALA214H, ALA235H, ALA235J, ALA237H, ALA237J, ALA244H, ALA244J, ALA245H, ALA245J, ALA248H, ALA248J, ALA251J, ARG185H, ARG185J, ARG191H, ARG191J, ARG229H, ARG229J, ARG242H, ARG242J, ASN186H, ASN186J, ASN212H, ASN212J, ASP184H, ASP184J, ASP215H, ASP215J, ASP226H, ASP226J, ASP249H, ASP249J, GLU130J, GLU136H, GLU136J, GLU190H, GLU190J, GLU208H, GLU208J, GLU211H, GLU211J, GLU219H, GLU219J, GLU224H, GLU224J, GLU228H, GLU228J, GLU239H, GLU239J, GLU246H, GLU246J, GLU250H, GLU250J, GLY220H, GLY220J, HIS238H, HIS238J, ILE209H, ILE209J, ILE233H, ILE233J, LEU188H, LEU188J, LEU189H, LEU189J, LEU207H, LEU207J, LEU247H, LEU247J, LEU254H, LEU254J, LYS202H, LYS202J, LYS227H, LYS227J, LYS243H, LYS243J, MET200H, MET200J, MET204H, MET204J, MET240H, MET240J, MET241H, MET241J, PHE131H, PHE131J, PRO197H, PRO197J, PRO232H, PRO232J, SER217H, SER217J, SER236H, SER236J, THR187H, THR187J, TYR198H, TYR198J, TYR230H, TYR230J, VAL201H, VAL201J, VAL213H, VAL213J, VAL216H, VAL216J, VAL231H, VAL231J, VAL234H, VAL234J
• H-L: ALA127H, ALA127L, ALA138H, ALA138L, ALA142H, ALA142L, ALA149H, ALA149L, ALA150H, ALA150L, ALA235H, ALA235L, ALA245H, ALA245L, ALA248H, ALA248L, ALA267H, ALA267L, ALA28H, ALA28L, ALA51H, ALA51L, ALA52H, ALA52L, ALA56H, ALA56L, ALA6H, ALA6L, ARG128H, ARG128L, ARG129H, ARG129L, ARG155H, ARG155L, ARG191H, ARG229H, ARG229L, ARG242H, ARG242L, ARG252H, ARG252L, ARG263H, ARG263L, ARG27H, ARG27L, ARG30H, ARG30L, ARG36H, ARG36L, ASN13H, ASN13L, ASN141H, ASN141L, ASP133H, ASP133L, ASP143H, ASP143L, ASP162H, ASP162L, ASP21H, ASP21L, ASP226H, ASP226L, ASP249H, ASP249L, ASP25H, ASP25L, ASP269H, ASP269L, ASP281H, ASP281L, ASP29H, ASP29L, ASP32H, ASP32L, ASP45H, ASP45L, ASP58H, ASP58L, ASP62H, ASP62L, CYS11H, CYS11L, CYS221H, CYS221L, CYS48H, CYS48L, GLN158H, GLN158L, GLU130H, GLU130L, GLU136H, GLU136L, GLU159H, GLU159L, GLU193H, GLU193L, GLU228H, GLU228L, GLU239H, GLU239L, GLU246H, GLU246L, GLU250H, GLU250L, GLU253H, GLU253L, GLU26H, GLU26L, GLU280H, GLU280L, GLU31H, GLU31L, GLU34H, GLU34L, GLU47H, GLU47L, GLU50H, GLU50L, GLU54H, GLU54L, GLY126H, GLY126L, GLY12H, GLY12L, GLY152H, GLY152L, GLY15H, GLY15L, GLY270H, GLY270L, GLY39H, GLY39L, HIS238H, HIS238L, HIS266H, HIS266L, ILE139H, ILE139L, ILE233H, ILE233L, ILE59H, ILE59L, ILE7H, ILE7L, ILE9H, ILE9L, LEU125H, LEU125L, LEU132H, LEU132L, LEU144H, LEU144L, LEU148H, LEU148L, LEU14H, LEU14L, LEU23H, LEU23L, LEU24H, LEU24L, LEU262H, LEU262L, LEU273H, LEU273L, LYS10H, LYS10L, LYS146H, LYS146L, LYS227H, LYS227L, LYS243H, LYS243L, LYS256H, LYS256L, LYS271H, LYS271L, LYS275H, LYS275L, LYS277H, LYS277L, LYS43H, LYS43L, MET137H, MET137L, MET145H, MET145L, MET18H, MET18L, MET19H, MET19L, MET20H, MET20L, MET22H, MET22L, MET279H, MET279L, MET44H, MET44L, MET55H, MET55L, PHE131H, PHE131L, PHE154H, PHE154L, PHE194H, PHE194L, PHE278H, PHE278L, PHE35H, PHE35L, PHE63H, PHE63L, PHE8H, PHE8L, PRO134H, PRO134L, PRO232H, PRO232L, PRO265H, PRO265L, PRO268H, PRO268L, PRO282H, PRO282L, PRO73H, SER17H, SER17L, SER236H, SER236L, SER274H, SER274L, SER41H, SER41L, THR151H, THR151L, THR264H, THR264L, THR40H, THR40L, TYR140H, TYR140L, TYR230H, TYR230L, VAL135H, VAL135L, VAL147H, VAL147L, VAL153H, VAL153L, VAL156H, VAL156L, VAL231H, VAL231L, VAL234H, VAL234L, VAL261H, VAL261L, VAL272H, VAL272L, VAL33H, VAL33L, VAL37H, VAL37L, VAL38H, VAL38L, VAL3H, VAL3L, VAL42H, VAL42L, VAL49H, VAL49L
• I-K: ALA127I, ALA127K, ALA138I, ALA138K, ALA142I, ALA142K, ALA149I, ALA149K, ALA150I, ALA150K, ALA235I, ALA235K, ALA245I, ALA245K, ALA248I, ALA248K, ALA267I, ALA267K, ALA28I, ALA28K, ALA51I, ALA51K, ALA52I, ALA52K, ALA56I, ALA56K, ALA6I, ALA6K, ARG128I, ARG128K, ARG129I, ARG129K, ARG155I, ARG155K, ARG229I, ARG229K, ARG242I, ARG242K, ARG252I, ARG252K, ARG263I, ARG263K, ARG27I, ARG27K, ARG30I, ARG30K, ARG36I, ARG36K, ASN13I, ASN13K, ASN141I, ASN141K, ASP133I, ASP133K, ASP143I, ASP143K, ASP162I, ASP162K, ASP21I, ASP21K, ASP226I, ASP226K, ASP249I, ASP249K, ASP25I, ASP25K, ASP269I, ASP269K, ASP281I, ASP281K, ASP29I, ASP29K, ASP32I, ASP32K, ASP45I, ASP45K, ASP58I, ASP58K, ASP62K, CYS11I, CYS11K, CYS221I, CYS221K, CYS48I, CYS48K, GLN158I, GLN158K, GLU130I, GLU130K, GLU136I, GLU136K, GLU159I, GLU159K, GLU193I, GLU193K, GLU228I, GLU228K, GLU239I, GLU239K, GLU246I, GLU246K, GLU250I, GLU250K, GLU253I, GLU253K, GLU26I, GLU26K, GLU280I, GLU280K, GLU283I, GLU283K, GLU31I, GLU31K, GLU34I, GLU34K, GLU47I, GLU47K, GLU50I, GLU50K, GLU54I, GLU54K, GLY126I, GLY126K, GLY12I, GLY12K, GLY152I, GLY152K, GLY15I, GLY15K, GLY270I, GLY270K, GLY39I, GLY39K, HIS238I, HIS238K, HIS266I, HIS266K, ILE139I, ILE139K, ILE233I, ILE233K, ILE59I, ILE59K, ILE7I, ILE7K, ILE9I, ILE9K, LEU125I, LEU125K, LEU132I, LEU132K, LEU144I, LEU144K, LEU148I, LEU148K, LEU14I, LEU14K, LEU23I, LEU23K, LEU24I, LEU24K, LEU262I, LEU262K, LEU273I, LEU273K, LYS10I, LYS10K, LYS146I, LYS146K, LYS227I, LYS227K, LYS243I, LYS243K, LYS256I, LYS256K, LYS271I, LYS271K, LYS275I, LYS275K, LYS277I, LYS277K, LYS43I, LYS43K, MET137I, MET137K, MET145I, MET145K, MET18I, MET18K, MET19I, MET19K, MET20I, MET20K, MET22I, MET22K, MET279I, MET279K, MET44I, MET44K, MET55I, MET55K, PHE131I, PHE131K, PHE154I, PHE154K, PHE194I, PHE194K, PHE278I, PHE278K, PHE35I, PHE35K, PHE63I, PHE63K, PHE8I, PHE8K, PRO134I, PRO134K, PRO232I, PRO232K, PRO265I, PRO265K, PRO268I, PRO268K, PRO282I, PRO282K, SER17I, SER17K, SER236I, SER236K, SER274I, SER274K, SER41I, SER41K, THR151I, THR151K, THR264I, THR264K, THR40I, THR40K, TYR140I, TYR140K, TYR230I, TYR230K, VAL135I, VAL135K, VAL147I, VAL147K, VAL153I, VAL153K, VAL156I, VAL156K, VAL231I, VAL231K, VAL234I, VAL234K, VAL261I, VAL261K, VAL272I, VAL272K, VAL33I, VAL33K, VAL37I, VAL37K, VAL38I, VAL38K, VAL3I, VAL3K, VAL42I, VAL42K, VAL49I, VAL49K
• I-L: ALA199I, ALA199L, ALA203I, ALA203L, ALA205I, ALA205L, ALA206I, ALA206L, ALA210I, ALA210L, ALA214I, ALA214L, ALA235I, ALA235L, ALA237I, ALA237L, ALA244I, ALA244L, ALA245I, ALA245L, ALA248I, ALA248L, ALA251L, ARG185I, ARG185L, ARG191I, ARG191L, ARG229I, ARG229L, ARG242I, ARG242L, ASN186I, ASN186L, ASN212I, ASN212L, ASP184I, ASP184L, ASP215I, ASP215L, ASP226I, ASP226L, ASP249I, ASP249L, GLU130L, GLU136I, GLU136L, GLU190I, GLU190L, GLU208I, GLU208L, GLU211I, GLU211L, GLU219I, GLU219L, GLU224I, GLU224L, GLU228I, GLU228L, GLU239I, GLU239L, GLU246I, GLU246L, GLU250I, GLU250L, GLY220I, GLY220L, HIS238I, HIS238L, ILE209I, ILE209L, ILE233I, ILE233L, LEU188I, LEU188L, LEU189I, LEU189L, LEU207I, LEU207L, LEU247I, LEU247L, LEU254I, LEU254L, LYS202I, LYS202L, LYS227I, LYS227L, LYS243I, LYS243L, MET200I, MET200L, MET204I, MET204L, MET240I, MET240L, MET241I, MET241L, PHE131I, PHE131L, PRO197I, PRO197L, PRO232I, PRO232L, SER217I, SER217L, SER236I, SER236L, THR187I, THR187L, TYR198I, TYR198L, TYR230I, TYR230L, VAL201I, VAL201L, VAL213I, VAL213L, VAL216I, VAL216L, VAL231I, VAL231L, VAL234I, VAL234L
• J-K: ALA199K, ALA260J, ARG252J, ARG263J, ARG276J, ASN196K, ASN258J, ASN258K, ASP249J, ASP259J, GLU195K, GLU250K, GLU253J, GLU253K, GLU255J, GLU255K, GLU280J, LEU189K, LEU247K, LEU254J, LEU254K, LEU262J, LYS202K, LYS256J, LYS256K, LYS275J, LYS277J, MET200K, MET204K, MET279J, PHE278J, PRO197K, SER257J, SER257K, TYR198K, VAL201K, VAL261J
• J-L: ALA199J, ALA260L, ARG252L, ARG263L, ARG276L, ASN196J, ASN258J, ASN258L, ASP249L, ASP259L, GLU195J, GLU250J, GLU253J, GLU253L, GLU255J, GLU255L, GLU280L, LEU189J, LEU247J, LEU254J, LEU254L, LEU262L, LYS202J, LYS256J, LYS256L, LYS275L, LYS277L, MET200J, MET204J, MET279L, PHE278L, PRO197J, SER257J, SER257L, TYR198J, VAL201J, VAL261L
• K-L: ALA199L, ALA260K, ARG252K, ARG263K, ARG276K, ASN196L, ASN258K, ASN258L, ASP249K, ASP259K, GLU195L, GLU250L, GLU253K, GLU253L, GLU255K, GLU255L, GLU280K, LEU189L, LEU247L, LEU254K, LEU254L, LEU262K, LYS202L, LYS256K, LYS256L, LYS275K, LYS277K, MET200L, MET204L, MET279K, PHE278K, PRO197L, SER257K, SER257L, TYR198L, VAL201L, VAL261K