3IHY

human pik3c3 crystal structure

• Total interactions analyzed: 10
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 94
  • Norm. En. per Res.: -2.8691
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-44.9657	-90.2989	-134.435	-269.6995	94	9	3	5628	5	60	32
A-D	0.0	0.0	-10.4925	-10.4925	46	0	0	973	0	17	20
A-E	-5.5529	-26.2498	-39.1608	-70.9635	60	1	0	1787	1	41	50
B-C	-6.0211	-30.2233	-62.2504	-98.4947	68	2	0	2779	3	55	56
B-D	0.0	-16.5997	-28.3837	-44.9834	40	3	0	1420	0	28	24
D-E	-4.2364	-37.853	-27.3596	-69.449	40	0	0	1556	3	16	21

Interface residues

• A-B: ALA615A, ALA615B, ALA691A, ALA691B, ARG566A, ARG566B, ARG705A, ARG705B, ARG768A, ARG768B, ASN565A, ASN565B, ASN570A, ASN570B, ASN702A, ASN702B, ASP695A, ASP695B, ASP743A, ASP743B, ASP747A, ASP747B, ASP769A, ASP769B, ASP830A, ASP830B, GLN701A, GLN701B, GLU562A, GLU562B, GLU692A, GLU692B, GLU697A, GLU697B, GLU782A, GLU782B, GLU785B, GLY564A, GLY564B, GLY698A, GLY698B, GLY763A, GLY763B, HIS745A, HIS745B, LEU611A, LEU611B, LEU616A, LEU616B, LEU694A, LEU694B, LEU746A, LEU746B, LEU773A, LEU773B, LEU833A, LEU833B, LYS567A, LYS567B, LYS568A, LYS568B, LYS569A, LYS569B, LYS613A, LYS613B, LYS678B, LYS706A, LYS706B, LYS771A, LYS771B, LYS781A, MET617A, MET617B, PHE612A, PHE612B, PRO689A, PRO770A, PRO770B, PRO772A, PRO772B, PRO829A, PRO829B, SER563A, SER563B, SER614A, SER614B, SER699A, SER699B, THR696A, THR696B, TYR764A, TYR764B, VAL693A, VAL693B
• A-D: ALA609A, ALA708A, ARG566A, ARG705A, ASN702D, ASN780D, ASP695D, GLN574A, GLN620A, GLN686A, GLU571A, GLU607A, GLU692A, GLU697A, GLU697D, GLU711A, GLU782D, GLU785D, GLU834D, GLU865D, GLY698D, HIS745D, LEU694D, LEU746D, LEU773D, LEU833D, LEU870D, LYS567A, LYS630A, LYS706A, LYS753A, LYS771D, LYS781D, LYS837D, PHE622A, PHE684A, PHE871D, PRO709A, PRO772D, SER699D, THR608A, THR610A, THR696A, THR696D, THR754A, TYR707A
• A-E: ALA719A, ARG293E, ARG320E, ARG659A, ARG811A, ASN297E, ASN325E, ASN662A, ASN662E, ASP285E, ASP388E, ASP532A, ASP627A, ASP664A, ASP723A, GLN326E, GLN801A, GLU390E, GLU661A, GLU720A, GLU797A, GLU797E, GLY353E, HIS284E, HIS808A, LEU286E, LEU296E, LEU323E, LEU541A, LEU658A, LEU663A, LEU663E, LEU665A, LEU807A, LYS287E, LYS354E, LYS356E, LYS485A, LYS533A, LYS600A, LYS660A, LYS660E, LYS666A, LYS727A, LYS727E, LYS800A, LYS800E, MET538A, PHE319E, PRO288E, PRO357E, SER487A, SER534A, THR324E, THR804A, TRP355E, TYR321E, TYR322E, VAL535A, VAL537A
• B-C: ALA290C, ALA329C, ALA719B, ALA719C, ARG293C, ARG320C, ARG659B, ARG811B, ASN289C, ASN297C, ASN325C, ASN662B, ASN662C, ASP285C, ASP388B, ASP388C, ASP532B, ASP627B, ASP664B, ASP723B, ASP723C, ASP852C, GLN326C, GLN801B, GLN801C, GLU327C, GLU626B, GLU661B, GLU720B, GLU797B, GLU797C, GLY353C, HIS284C, HIS808B, LEU286C, LEU296C, LEU323C, LEU541B, LEU658B, LEU663B, LEU663C, LEU665B, LYS287C, LYS354C, LYS356C, LYS533B, LYS600B, LYS660B, LYS666B, LYS727B, LYS727C, LYS800B, LYS800C, PHE319C, PRO288C, PRO357C, PRO592B, SER487B, SER534B, THR324C, THR804B, THR804C, TRP355C, TYR321C, TYR322C, TYR812B, VAL300C, VAL537B
• B-D: ALA575B, ALA615D, ARG561D, ARG566D, ARG572B, ASN565D, ASN570B, ASN580B, ASN584B, ASP579B, ASP587B, ASP743D, ASP747D, ASP761D, GLN560D, GLN574B, GLU562D, GLU571B, GLU581B, GLU607B, GLY564D, GLY578B, HIS745D, LEU576B, LEU577B, LEU585B, LEU616D, LYS567B, LYS568B, LYS568D, LYS569D, LYS582B, LYS613D, LYS624B, MET583B, MET617D, PRO606B, SER563D, SER586B, SER614D
• D-E: ALA382E, ALA527E, ARG385E, ARG536E, ARG799D, ASP532E, ASP852D, ASP864D, CYS484E, GLN386E, GLN473E, GLN791D, GLN796D, GLN860D, GLU793D, GLU797D, GLU853D, GLU854D, GLY531E, HIS857D, HIS868D, ILE863D, LYS485E, LYS530E, LYS533E, LYS800D, PHE478E, SER481E, SER534E, SER861D, THR477E, THR790D, THR804D, TYR795D, TYR803D, VAL381E, VAL535E, VAL537E, VAL856D, VAL867D