3IG6

low molecular weigth human urokinase type plasminogen activator 2-[6- (3'-aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1- yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 111
  • Norm. En. per Res.: -2.0191
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-5.8805	0.0	687.665	681.7845	26	6	0	1895	0	0	0
B-D	-23.6444	-49.0566	-151.417	-224.118	111	10	0	7363	3	42	39
C-D	-27.7061	0.0	509.127	481.4209	50	24	0	6612	2	2	4

Interface residues

• A-B: ALA112B, ARG206B, CYS111B, CYS122B, CYS13A, CYS50B, GLN113B, GLN119B, GLN15A, GLY14A, ILE118B, ILE121B, ILE47B, LEU123B, LEU209B, LEU46B, LEU68B, MET207B, PRO114B, PRO28B, PRO49B, SER115B, SER48B, THR120B, THR208B, TRP29B
• B-D: ALA221B, ALA96B, ALA96D, ALA98B, ALA98D, ARG217B, ARG217D, ARG35B, ARG35D, ARG36B, ARG37B, ASN101D, ASN145B, ASN74B, ASP148B, ASP223B, ASP60B, ASP60D, ASP63B, ASP63D, ASP93D, ASP97B, ASP97D, CYS191B, CYS220B, CYS42B, CYS58B, CYS58D, GLN169D, GLN170D, GLN192B, GLN192D, GLU153B, GLU175D, GLU62D, GLY142B, GLY173D, GLY193B, GLY216B, GLY216D, GLY218B, GLY218D, GLY37B, HIS100B, HIS100D, HIS170D, HIS241D, HIS36D, HIS37B, HIS57B, HIS57D, HIS91D, HIS99B, HIS99D, ILE17B, ILE60B, ILE60D, ILE89D, LEU150B, LEU222B, LEU73B, LEU88D, LEU90D, LEU97B, LEU97D, LYS143B, LYS143D, LYS179D, LYS223B, LYS224B, LYS224D, LYS61B, LYS61D, LYS62D, LYS92D, MET180D, PHE141B, PHE59D, PRO152B, PRO170D, PRO60D, SER146B, SER146D, SER174D, SER37B, SER95B, SER95D, THR147B, THR177D, THR178D, THR39B, THR39D, THR97B, THR97D, TYR149B, TYR151B, TYR151D, TYR171D, TYR172D, TYR34B, TYR40B, TYR40D, TYR60B, TYR60D, TYR64D, TYR94B, TYR94D, VAL176D, VAL38B, VAL41B, VAL41D
• C-D: ALA112D, ARG116D, ARG206D, ASN26D, CYS111D, CYS122D, CYS13C, CYS50D, GLN113D, GLN119D, GLN12C, GLN15C, GLN27D, GLU137D, GLU25D, GLY14C, GLY205D, ILE108D, ILE118D, ILE121D, ILE24D, ILE47D, LEU123D, LEU18C, LEU203D, LEU209D, LEU46D, LEU68D, LYS10C, LYS16C, MET157D, MET207D, MET81D, PHE11C, PHE83D, PRO114D, PRO28D, PRO49D, SER115D, SER202D, SER48D, THR117D, THR120D, THR139D, THR17C, THR208D, THR22D, THR23D, TRP29D, VAL200D