3IFH

crystal structure of succinate-semialdehyde dehydrogenase from burkholderia pseudomallei, part 2 of 2

• Total interactions analyzed: 120
• Total true interactions: 26
• Strongest Interaction:
  • Chains: Q-R
  • Int. Res.: 98
  • Norm. En. per Res.: -4.8513
• Hub Node: 3(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
Q-R	-76.636	-203.9187	-194.868	-475.4227	98	17	0	7779	18	51	40
Q-S	-72.4876	-24.8861	-234.023	-331.3967	99	15	5	9479	3	39	39
Q-T	-230.7269	-34.6196	-676.313	-941.6595	258	48	33	29878	7	57	50
R-S	-218.1232	6.1894	-657.158	-869.0918	240	32	30	29218	7	54	49
R-T	-71.8624	-17.2075	-223.963	-313.0329	97	16	6	9362	3	38	41
S-T	-64.6327	-177.4861	-194.868	-436.9868	98	14	0	7754	20	51	39
T-W	0.0	0.0	-0.015	-0.015	3	0	0	4	0	2	3
U-V	-56.7717	-174.0585	-199.582	-430.4122	98	11	0	7847	17	51	38
U-W	-83.9556	-33.7944	-229.831	-347.5809	103	17	5	9442	3	40	36
U-X	-217.6536	-70.3738	-676.764	-964.7915	252	39	31	29613	9	57	50
V-W	-225.2552	4.3698	-662.849	-883.7344	245	34	28	29201	5	53	50
V-X	-50.4637	-15.1172	-224.071	-289.6519	98	14	5	9533	0	38	38
W-X	-68.3917	-186.9954	-189.587	-444.974	98	17	0	7849	19	51	39
Y-Z	-70.7468	-198.5855	-177.723	-447.0553	94	14	0	7649	19	51	42
Y-1	-73.9271	-29.333	-221.909	-325.1691	101	14	6	9382	2	39	39
Y-2	-239.8368	-80.3231	-699.14	-1019.2999	247	46	31	30341	10	59	48
Z-1	-179.4339	5.76	-661.919	-835.5928	247	43	30	29895	7	56	49
Z-2	-69.1356	-16.9051	-235.204	-321.2446	100	15	6	9698	3	38	37
1-2	-76.3612	-176.2918	-197.341	-449.994	98	11	0	8142	18	52	42
2-3	0.0	18.0171	-23.2137	-5.1966	39	2	0	1593	0	19	14
3-4	-71.8307	-178.5286	-190.937	-441.2964	101	13	0	7911	16	51	41
3-5	-71.0518	-24.034	-18.3298	-113.4156	33	0	0	1053	0	4	5
3-6	-276.4344	-85.5029			49
4-5	-191.5648	10.1808	-2.2755	-183.6595	48	0	0	185	0	3	1
4-6	-64.1959	-20.1154			20
5-6	-72.8534	-202.1446			24

Interface residues

• Q-R: ALA112Q, ALA112R, ALA115Q, ALA115R, ALA122Q, ALA122R, ALA129Q, ALA129R, ALA138Q, ALA138R, ALA483Q, ALA483R, ALA71Q, ALA71R, ALA75Q, ALA75R, ALA76Q, ALA76R, ARG127Q, ARG127R, ARG141Q, ARG141R, ARG427Q, ARG427R, ARG430Q, ARG430R, ARG79Q, ARG79R, ASN449Q, ASN449R, ASP131R, ASP83Q, ASP83R, GLU119Q, GLU119R, GLU123Q, GLU123R, GLU124Q, GLU124R, GLU433Q, GLU433R, GLU450Q, GLU450R, GLY125Q, GLY125R, GLY130R, GLY426Q, GLY426R, HIS468Q, HIS468R, ILE142Q, ILE142R, ILE425Q, ILE425R, ILE471Q, ILE86Q, ILE86R, LEU480Q, LEU480R, LYS126Q, LYS126R, LYS140Q, LYS140R, LYS72Q, LYS72R, PHE117Q, PHE117R, PHE121Q, PHE121R, PHE82Q, PHE82R, SER116Q, SER116R, SER467Q, SER467R, THR132Q, THR132R, THR135Q, THR70Q, TRP120Q, TRP120R, TRP429Q, TRP429R, TYR113Q, TYR113R, TYR469Q, VAL128Q, VAL128R, VAL143Q, VAL143R, VAL428Q, VAL431Q, VAL451Q, VAL451R, VAL482Q, VAL482R, VAL484Q, VAL484R
• Q-S: ALA129Q, ALA129S, ALA138Q, ALA138S, ALA174Q, ALA71Q, ALA71S, ARG127Q, ARG127S, ARG141Q, ARG141S, ARG423Q, ARG423S, ARG427Q, ARG427S, ARG430Q, ARG430S, ARG67Q, ARG67S, ARG74Q, ARG74S, ASN139Q, ASN139S, ASN443Q, ASN443S, ASP131Q, ASP131S, ASP137Q, ASP137S, ASP269Q, ASP269S, ASP424Q, ASP424S, GLU123Q, GLU123S, GLU124Q, GLU124S, GLU147S, GLU73Q, GLU73S, GLY125Q, GLY125S, GLY130Q, GLY130S, GLY426Q, GLY426S, ILE142Q, ILE142S, ILE425Q, ILE425S, ILE442Q, ILE442S, LEU133Q, LEU133S, LEU420S, LEU480Q, LEU480S, LYS126Q, LYS126S, LYS140Q, LYS140S, LYS146Q, LYS146S, LYS478Q, LYS478S, LYS69Q, LYS69S, LYS72Q, LYS72S, MET68Q, MET68S, PRO134Q, PRO134S, PRO136Q, PRO136S, SER422Q, SER422S, THR132Q, THR132S, THR135Q, THR135S, THR70Q, THR70S, TRP429Q, TRP429S, TYR421Q, TYR421S, VAL128Q, VAL128S, VAL143Q, VAL143S, VAL144Q, VAL144S, VAL145Q, VAL145S, VAL428Q, VAL428S, VAL475Q, VAL484S
• Q-T: ALA129Q, ALA129T, ALA238Q, ALA238T, ALA245Q, ALA245T, ALA248Q, ALA248T, ALA274Q, ALA274T, ALA281Q, ALA281T, ALA417Q, ALA417T, ALA418Q, ALA418T, ALA432Q, ALA432T, ALA434Q, ALA434T, ALA452Q, ALA452T, ALA483Q, ALA483T, ARG141Q, ARG141T, ARG229Q, ARG229T, ARG241Q, ARG241T, ARG423Q, ARG423T, ARG430Q, ARG430T, ARG464Q, ARG464T, ARG67Q, ARG67T, ASN139Q, ASN139T, ASN225Q, ASN225T, ASN410Q, ASN410T, ASN443Q, ASN443T, ASN449Q, ASN449T, ASP131Q, ASP131T, ASP137Q, ASP137T, ASP472Q, ASP472T, ASP473Q, ASP473T, CYS481Q, CYS481T, GLN246Q, GLN246T, GLN459Q, GLN459T, GLN60T, GLU124Q, GLU124T, GLU147Q, GLU147T, GLU257Q, GLU413Q, GLU413T, GLU433Q, GLU433T, GLU436Q, GLU436T, GLU450Q, GLU450T, GLU465Q, GLU465T, GLY130Q, GLY130T, GLY150Q, GLY150T, GLY240Q, GLY240T, GLY259Q, GLY278Q, GLY278T, GLY415T, GLY438Q, GLY438T, GLY441Q, GLY441T, GLY445Q, GLY445T, GLY455Q, GLY455T, GLY456Q, GLY456T, GLY461Q, GLY461T, GLY463Q, GLY463T, GLY466Q, GLY466T, GLY470Q, GLY470T, HIS468Q, HIS468T, ILE142Q, ILE142T, ILE149Q, ILE149T, ILE227Q, ILE227T, ILE425Q, ILE425T, ILE442Q, ILE442T, ILE447Q, ILE447T, ILE477Q, ILE477T, LEU133Q, LEU133T, LEU231Q, LEU231T, LEU242Q, LEU242T, LEU243Q, LEU243T, LEU254Q, LEU254T, LEU256Q, LEU256T, LEU258Q, LEU258T, LEU416Q, LEU416T, LEU420Q, LEU420T, LEU435Q, LEU435T, LEU446Q, LEU446T, LEU462Q, LEU462T, LEU480Q, LEU480T, LYS140Q, LYS140T, LYS146Q, LYS146T, LYS230Q, LYS230T, LYS252Q, LYS252T, LYS253Q, LYS253T, LYS458Q, LYS458T, LYS478Q, LYS478T, MET244Q, MET244T, MET439Q, MET439T, PHE233Q, PHE233T, PHE414Q, PHE414T, PHE454Q, PHE454T, PRO134Q, PRO134T, PRO136Q, PRO136T, PRO148Q, PRO148T, PRO226Q, PRO226T, PRO249Q, PRO249T, PRO453Q, PRO453T, SER116Q, SER116T, SER236Q, SER236T, SER247Q, SER247T, SER422Q, SER448Q, SER448T, SER460Q, SER460T, SER467Q, SER467T, THR132Q, THR132T, THR135Q, THR135T, THR237Q, THR237T, THR250Q, THR250T, THR255T, THR412Q, THR412T, THR444Q, THR444T, TRP120Q, TRP120T, TRP429Q, TRP429T, TRP63Q, TRP63T, TYR419Q, TYR419T, TYR421Q, TYR421T, TYR437Q, TYR437T, TYR469Q, TYR469T, TYR479Q, TYR479T, VAL128Q, VAL143Q, VAL143T, VAL144Q, VAL144T, VAL145Q, VAL145T, VAL228Q, VAL228T, VAL239T, VAL251Q, VAL251T, VAL292Q, VAL292T, VAL428Q, VAL428T, VAL431Q, VAL431T, VAL440Q, VAL440T, VAL451Q, VAL451T, VAL457Q, VAL457T, VAL475Q, VAL475T, VAL476Q, VAL476T, VAL482Q, VAL482T, VAL484Q, VAL484T
• R-S: ALA129R, ALA129S, ALA238R, ALA238S, ALA245R, ALA245S, ALA248R, ALA248S, ALA274R, ALA274S, ALA281R, ALA281S, ALA417R, ALA417S, ALA418R, ALA418S, ALA432R, ALA432S, ALA434R, ALA434S, ALA452R, ALA452S, ALA483R, ALA483S, ARG141R, ARG141S, ARG229R, ARG229S, ARG241R, ARG241S, ARG285R, ARG423R, ARG423S, ARG430R, ARG430S, ARG464R, ARG464S, ARG67R, ARG67S, ASN139R, ASN139S, ASN225R, ASN410R, ASN410S, ASN443R, ASN443S, ASN449R, ASN449S, ASP131R, ASP131S, ASP137R, ASP137S, ASP472R, ASP472S, ASP473R, CYS481R, CYS481S, GLN246R, GLN246S, GLN459R, GLN459S, GLU147R, GLU147S, GLU257R, GLU257S, GLU413R, GLU413S, GLU433R, GLU433S, GLU436R, GLU436S, GLU450R, GLU450S, GLU465R, GLU465S, GLY130R, GLY130S, GLY150R, GLY150S, GLY240R, GLY240S, GLY259R, GLY415R, GLY438R, GLY438S, GLY441R, GLY441S, GLY445R, GLY445S, GLY455R, GLY455S, GLY456R, GLY456S, GLY461R, GLY461S, GLY463R, GLY463S, GLY466S, HIS468R, HIS468S, ILE142R, ILE142S, ILE149R, ILE149S, ILE227R, ILE425R, ILE425S, ILE442R, ILE442S, ILE447R, ILE447S, ILE477R, ILE477S, LEU133R, LEU133S, LEU242R, LEU242S, LEU243R, LEU243S, LEU254R, LEU254S, LEU256R, LEU256S, LEU258R, LEU258S, LEU416R, LEU416S, LEU420R, LEU420S, LEU435R, LEU435S, LEU446R, LEU446S, LEU462R, LEU462S, LEU480R, LEU480S, LYS140R, LYS140S, LYS146R, LYS146S, LYS230R, LYS230S, LYS252R, LYS252S, LYS253R, LYS253S, LYS458R, LYS458S, LYS478R, LYS478S, MET244R, MET244S, MET439R, MET439S, PHE233S, PHE414R, PHE414S, PHE454R, PHE454S, PRO134R, PRO134S, PRO136R, PRO136S, PRO148R, PRO148S, PRO226R, PRO226S, PRO249R, PRO249S, PRO453R, PRO453S, SER116R, SER116S, SER247R, SER247S, SER448R, SER448S, SER460R, SER460S, SER467R, SER467S, THR132R, THR135R, THR135S, THR237R, THR237S, THR250R, THR250S, THR412R, THR412S, THR444R, THR444S, TRP120R, TRP120S, TRP429R, TRP429S, TRP63R, TRP63S, TYR419R, TYR419S, TYR421R, TYR421S, TYR437R, TYR437S, TYR469R, TYR469S, TYR479R, TYR479S, VAL143R, VAL143S, VAL144R, VAL144S, VAL145R, VAL145S, VAL228R, VAL228S, VAL239S, VAL251R, VAL251S, VAL292R, VAL292S, VAL428R, VAL428S, VAL431R, VAL431S, VAL440R, VAL440S, VAL451R, VAL451S, VAL457R, VAL457S, VAL475R, VAL475S, VAL476R, VAL476S, VAL482R, VAL482S, VAL484R, VAL484S
• R-T: ALA129R, ALA129T, ALA138R, ALA138T, ALA71R, ALA71T, ARG127R, ARG127T, ARG141R, ARG141T, ARG423R, ARG423T, ARG427R, ARG427T, ARG430R, ARG430T, ARG67R, ARG67T, ARG74R, ARG74T, ASN139R, ASN139T, ASN443R, ASN443T, ASP131R, ASP131T, ASP137R, ASP137T, ASP269R, ASP269T, ASP424R, ASP424T, GLU123R, GLU123T, GLU124R, GLU124T, GLU73R, GLU73T, GLY125R, GLY125T, GLY130R, GLY130T, GLY426R, GLY426T, ILE142R, ILE142T, ILE425R, ILE425T, ILE442R, ILE442T, LEU133R, LEU133T, LEU420R, LEU480R, LEU480T, LYS126R, LYS126T, LYS140R, LYS140T, LYS146R, LYS146T, LYS478R, LYS478T, LYS69R, LYS69T, LYS72R, LYS72T, MET68R, MET68T, PRO134R, PRO134T, PRO136R, PRO136T, SER422R, SER422T, THR132R, THR132T, THR135R, THR135T, THR70R, THR70T, TRP429R, TRP429T, TYR421R, TYR421T, VAL128R, VAL128T, VAL143R, VAL143T, VAL144R, VAL144T, VAL145R, VAL145T, VAL428R, VAL428T, VAL475T, VAL484R
• S-T: ALA112S, ALA112T, ALA115S, ALA115T, ALA122S, ALA122T, ALA129S, ALA129T, ALA483S, ALA483T, ALA71S, ALA71T, ALA75S, ALA75T, ALA76S, ALA76T, ARG127S, ARG127T, ARG141S, ARG141T, ARG427S, ARG427T, ARG430S, ARG430T, ARG79S, ARG79T, ASN449S, ASN449T, ASP424T, ASP83S, ASP83T, GLU119S, GLU119T, GLU123S, GLU123T, GLU124S, GLU124T, GLU433S, GLU433T, GLU450S, GLU450T, GLY125S, GLY125T, GLY130S, GLY130T, GLY426S, GLY426T, HIS468S, HIS468T, ILE142S, ILE142T, ILE425S, ILE425T, ILE86S, ILE86T, LEU133T, LEU480S, LEU480T, LYS126S, LYS126T, LYS140S, LYS140T, LYS72S, LYS72T, PHE117S, PHE117T, PHE121S, PHE121T, PHE82S, PHE82T, SER116S, SER116T, SER467S, SER467T, THR132S, THR132T, THR135S, THR70T, TRP120S, TRP120T, TRP429S, TRP429T, TYR113S, TYR113T, TYR469S, TYR469T, VAL128S, VAL128T, VAL143S, VAL143T, VAL431S, VAL431T, VAL451S, VAL451T, VAL482S, VAL482T, VAL484S, VAL484T
• T-W: ASP27T, SER26T, SER26W
• U-V: ALA112U, ALA112V, ALA115U, ALA115V, ALA122U, ALA122V, ALA129U, ALA129V, ALA138V, ALA432V, ALA483U, ALA483V, ALA71U, ALA71V, ALA75U, ALA75V, ALA76U, ALA76V, ARG127U, ARG127V, ARG141U, ARG141V, ARG427U, ARG427V, ARG430U, ARG430V, ARG79U, ARG79V, ASN449U, ASN449V, ASP131V, ASP83U, ASP83V, GLU119U, GLU119V, GLU123U, GLU123V, GLU124U, GLU124V, GLU433U, GLU433V, GLU450U, GLU450V, GLY125U, GLY125V, GLY130V, GLY426U, GLY426V, HIS468U, HIS468V, ILE142U, ILE142V, ILE425U, ILE425V, ILE86U, ILE86V, LEU480U, LEU480V, LYS126U, LYS126V, LYS140U, LYS140V, LYS72U, LYS72V, PHE117U, PHE117V, PHE121U, PHE121V, PHE82U, PHE82V, SER116U, SER116V, SER467U, SER467V, THR132U, THR132V, THR135U, THR135V, THR70U, TRP120U, TRP120V, TRP429U, TRP429V, TYR113U, TYR113V, TYR469U, VAL128U, VAL128V, VAL143U, VAL143V, VAL428V, VAL431V, VAL451U, VAL451V, VAL482U, VAL482V, VAL484U, VAL484V
• U-W: ALA129U, ALA129W, ALA138U, ALA138W, ALA270W, ALA71U, ALA71W, ARG127U, ARG127W, ARG141U, ARG141W, ARG423U, ARG423W, ARG427U, ARG427W, ARG430U, ARG430W, ARG67U, ARG67W, ARG74U, ARG74W, ASN139U, ASN139W, ASN443U, ASN443W, ASP131U, ASP131W, ASP137U, ASP137W, ASP269U, ASP269W, ASP271U, ASP271W, ASP424U, ASP424W, GLU123U, GLU124U, GLU124W, GLU73U, GLU73W, GLY125U, GLY125W, GLY130U, GLY130W, GLY426U, GLY426W, ILE142U, ILE142W, ILE425U, ILE425W, ILE442U, ILE442W, ILE471U, ILE471W, LEU133U, LEU133W, LEU420U, LEU420W, LEU480U, LEU480W, LYS126U, LYS126W, LYS140U, LYS140W, LYS146U, LYS146W, LYS478U, LYS478W, LYS69U, LYS69W, LYS72U, LYS72W, MET68U, MET68W, PRO134U, PRO134W, PRO136U, PRO136W, SER422U, SER422W, THR132U, THR132W, THR135U, THR135W, THR70U, THR70W, TRP429U, TRP429W, TYR421U, TYR421W, VAL128U, VAL128W, VAL143U, VAL143W, VAL144U, VAL144W, VAL145U, VAL145W, VAL428U, VAL428W, VAL475U, VAL482U, VAL484W
• U-X: ALA129U, ALA129X, ALA238U, ALA238X, ALA245U, ALA245X, ALA248U, ALA248X, ALA274U, ALA274X, ALA281U, ALA281X, ALA417U, ALA417X, ALA418U, ALA418X, ALA432U, ALA432X, ALA434U, ALA434X, ALA452U, ALA452X, ALA483U, ALA483X, ARG141U, ARG141X, ARG229U, ARG229X, ARG241U, ARG241X, ARG285X, ARG423U, ARG423X, ARG430U, ARG430X, ARG464U, ARG464X, ARG67U, ARG67X, ASN139U, ASN139X, ASN225U, ASN225X, ASN410U, ASN410X, ASN443U, ASN443X, ASN449U, ASN449X, ASP131U, ASP131X, ASP137U, ASP137X, ASP472U, ASP472X, ASP473U, ASP473X, CYS481U, CYS481X, GLN246U, GLN246X, GLN459U, GLN459X, GLN60X, GLU124X, GLU147U, GLU147X, GLU413U, GLU413X, GLU433U, GLU433X, GLU436U, GLU436X, GLU450U, GLU450X, GLU465U, GLU465X, GLY130U, GLY130X, GLY150U, GLY150X, GLY240U, GLY240X, GLY278U, GLY415X, GLY438U, GLY438X, GLY441U, GLY441X, GLY445U, GLY445X, GLY455U, GLY455X, GLY456U, GLY456X, GLY461U, GLY461X, GLY463U, GLY463X, GLY466U, GLY466X, GLY470X, HIS468U, HIS468X, ILE142U, ILE142X, ILE149U, ILE149X, ILE227U, ILE227X, ILE425U, ILE425X, ILE442U, ILE442X, ILE447U, ILE447X, ILE477U, ILE477X, LEU133U, LEU133X, LEU231U, LEU231X, LEU242U, LEU242X, LEU243U, LEU243X, LEU254U, LEU254X, LEU256U, LEU256X, LEU258U, LEU258X, LEU416U, LEU416X, LEU420U, LEU420X, LEU435U, LEU435X, LEU446U, LEU446X, LEU462U, LEU462X, LEU480U, LEU480X, LYS140U, LYS140X, LYS146U, LYS146X, LYS230U, LYS230X, LYS252U, LYS252X, LYS253U, LYS253X, LYS458U, LYS458X, LYS478U, LYS478X, MET244U, MET244X, MET439U, MET439X, MET68X, PHE233U, PHE233X, PHE414X, PHE454U, PHE454X, PRO134U, PRO134X, PRO136U, PRO136X, PRO148U, PRO148X, PRO226U, PRO226X, PRO249U, PRO249X, PRO453U, PRO453X, SER116U, SER116X, SER236U, SER247U, SER247X, SER422U, SER448U, SER448X, SER460U, SER460X, SER467U, SER467X, THR132U, THR132X, THR135U, THR135X, THR237U, THR237X, THR250U, THR250X, THR255U, THR412U, THR412X, THR444U, THR444X, TRP120U, TRP120X, TRP429U, TRP429X, TRP63U, TRP63X, TYR419U, TYR419X, TYR421U, TYR421X, TYR437U, TYR437X, TYR469U, TYR469X, TYR479U, TYR479X, VAL143U, VAL143X, VAL144U, VAL144X, VAL145U, VAL145X, VAL151X, VAL228U, VAL228X, VAL251U, VAL251X, VAL292U, VAL292X, VAL428U, VAL428X, VAL431U, VAL431X, VAL440U, VAL440X, VAL451U, VAL451X, VAL457U, VAL457X, VAL475U, VAL475X, VAL476U, VAL476X, VAL482U, VAL482X, VAL484U, VAL484X
• V-W: ALA129V, ALA129W, ALA238V, ALA238W, ALA245V, ALA245W, ALA248V, ALA248W, ALA274V, ALA274W, ALA281V, ALA281W, ALA417V, ALA417W, ALA418V, ALA418W, ALA432V, ALA432W, ALA434V, ALA434W, ALA452V, ALA452W, ALA483V, ALA483W, ARG141V, ARG141W, ARG229V, ARG229W, ARG241V, ARG241W, ARG285V, ARG285W, ARG423V, ARG423W, ARG430V, ARG430W, ARG464V, ARG464W, ARG67V, ARG67W, ASN139V, ASN139W, ASN225W, ASN410V, ASN410W, ASN443V, ASN443W, ASN449V, ASN449W, ASP131V, ASP131W, ASP137V, ASP137W, ASP472V, ASP472W, ASP473V, CYS481V, CYS481W, GLN246V, GLN246W, GLN459V, GLN459W, GLU124W, GLU147V, GLU147W, GLU257V, GLU413V, GLU413W, GLU433V, GLU433W, GLU436V, GLU436W, GLU450V, GLU450W, GLU465V, GLU465W, GLY130V, GLY130W, GLY150V, GLY150W, GLY240V, GLY240W, GLY259V, GLY278V, GLY278W, GLY415V, GLY415W, GLY438V, GLY438W, GLY441V, GLY441W, GLY445V, GLY445W, GLY455V, GLY455W, GLY456V, GLY456W, GLY461V, GLY461W, GLY463V, GLY463W, GLY466V, GLY466W, HIS468V, HIS468W, ILE142V, ILE142W, ILE149V, ILE149W, ILE227V, ILE425V, ILE425W, ILE442V, ILE442W, ILE447V, ILE447W, ILE477V, ILE477W, LEU133V, LEU133W, LEU242V, LEU242W, LEU243V, LEU243W, LEU254V, LEU254W, LEU256V, LEU256W, LEU258V, LEU258W, LEU416V, LEU416W, LEU420V, LEU420W, LEU435V, LEU435W, LEU446V, LEU446W, LEU462V, LEU462W, LEU480V, LEU480W, LYS140V, LYS140W, LYS146V, LYS146W, LYS230V, LYS230W, LYS252V, LYS252W, LYS253V, LYS253W, LYS458V, LYS458W, LYS478V, LYS478W, MET244V, MET244W, MET439V, MET439W, PHE233W, PHE414V, PHE414W, PHE454V, PHE454W, PRO134V, PRO134W, PRO136V, PRO136W, PRO148V, PRO148W, PRO226V, PRO226W, PRO249V, PRO249W, PRO453V, PRO453W, SER116V, SER116W, SER247V, SER247W, SER448V, SER448W, SER460V, SER460W, SER467V, SER467W, THR132V, THR132W, THR135V, THR135W, THR237V, THR237W, THR250V, THR250W, THR412V, THR412W, THR444V, THR444W, TRP120V, TRP120W, TRP429V, TRP429W, TRP63V, TRP63W, TYR419V, TYR419W, TYR421V, TYR421W, TYR437V, TYR437W, TYR469V, TYR469W, TYR479V, TYR479W, VAL143V, VAL143W, VAL144V, VAL144W, VAL145V, VAL145W, VAL228V, VAL228W, VAL251V, VAL251W, VAL292V, VAL292W, VAL428V, VAL428W, VAL431V, VAL431W, VAL440V, VAL440W, VAL451V, VAL451W, VAL457V, VAL457W, VAL475V, VAL475W, VAL476V, VAL476W, VAL482V, VAL482W, VAL484V, VAL484W
• V-X: ALA129V, ALA129X, ALA138V, ALA138X, ALA175V, ALA270X, ALA71V, ALA71X, ARG127V, ARG127X, ARG141V, ARG141X, ARG423V, ARG423X, ARG427V, ARG427X, ARG430V, ARG430X, ARG67V, ARG74V, ARG74X, ASN139V, ASN139X, ASN443V, ASN443X, ASP131V, ASP131X, ASP137V, ASP137X, ASP269V, ASP269X, ASP424V, ASP424X, GLU123V, GLU123X, GLU124V, GLU124X, GLU73V, GLU73X, GLY125V, GLY125X, GLY130V, GLY130X, GLY426V, GLY426X, ILE142V, ILE142X, ILE425V, ILE425X, ILE442V, ILE442X, LEU133V, LEU133X, LEU480V, LEU480X, LYS126V, LYS126X, LYS140V, LYS140X, LYS146V, LYS146X, LYS478V, LYS478X, LYS69V, LYS69X, LYS72V, LYS72X, MET68V, MET68X, PRO134V, PRO134X, PRO136V, PRO136X, SER422V, SER422X, THR132V, THR132X, THR135V, THR135X, THR70V, THR70X, TRP429V, TRP429X, TYR421V, TYR421X, VAL128V, VAL128X, VAL143V, VAL143X, VAL144V, VAL144X, VAL145V, VAL145X, VAL428V, VAL428X, VAL475V, VAL475X, VAL484V
• W-X: ALA112W, ALA112X, ALA115W, ALA115X, ALA122W, ALA122X, ALA129W, ALA129X, ALA432W, ALA483W, ALA483X, ALA71W, ALA71X, ALA75W, ALA75X, ALA76W, ALA76X, ARG127W, ARG127X, ARG141W, ARG141X, ARG427W, ARG427X, ARG430W, ARG430X, ARG79W, ARG79X, ASN449W, ASN449X, ASP424X, ASP83W, ASP83X, GLU119W, GLU119X, GLU123W, GLU123X, GLU124W, GLU124X, GLU433W, GLU433X, GLU450W, GLU450X, GLY125W, GLY125X, GLY426W, GLY426X, HIS468W, HIS468X, ILE142W, ILE142X, ILE425W, ILE425X, ILE471W, ILE86X, LEU133W, LEU133X, LEU480W, LEU480X, LYS126W, LYS126X, LYS140X, LYS72W, LYS72X, PHE117X, PHE121W, PHE121X, PHE82W, PHE82X, SER116W, SER116X, SER467W, SER467X, THR132W, THR132X, THR135W, THR135X, THR70W, THR70X, TRP120W, TRP120X, TRP429W, TRP429X, TYR113W, TYR113X, TYR469W, TYR469X, VAL128W, VAL128X, VAL143W, VAL143X, VAL428W, VAL431W, VAL451W, VAL451X, VAL482W, VAL482X, VAL484W, VAL484X
• Y-Z: ALA112Y, ALA112Z, ALA115Y, ALA122Y, ALA122Z, ALA129Y, ALA129Z, ALA138Z, ALA483Y, ALA483Z, ALA71Y, ALA71Z, ALA75Y, ALA75Z, ALA76Y, ALA76Z, ARG127Y, ARG127Z, ARG141Y, ARG141Z, ARG427Y, ARG427Z, ARG430Y, ARG430Z, ARG79Y, ARG79Z, ASN449Y, ASN449Z, ASP83Y, ASP83Z, GLU119Y, GLU119Z, GLU123Y, GLU123Z, GLU124Y, GLU124Z, GLU433Y, GLU433Z, GLU450Y, GLU450Z, GLY125Y, GLY125Z, GLY130Y, GLY130Z, GLY426Y, GLY426Z, HIS468Y, HIS468Z, ILE118Z, ILE142Y, ILE142Z, ILE425Y, ILE425Z, ILE471Z, LEU133Y, LEU133Z, LEU480Y, LYS126Y, LYS126Z, LYS140Y, LYS140Z, LYS72Y, LYS72Z, PHE117Y, PHE117Z, PHE121Y, PHE121Z, PHE82Y, PHE82Z, SER116Y, SER116Z, SER467Y, SER467Z, THR132Y, THR132Z, THR70Y, TRP120Y, TRP120Z, TRP429Y, TRP429Z, TYR113Y, TYR113Z, TYR469Y, TYR469Z, VAL128Y, VAL143Y, VAL143Z, VAL431Y, VAL451Y, VAL451Z, VAL482Y, VAL482Z, VAL484Y, VAL484Z
• Y-1: ALA1291, ALA129Y, ALA1381, ALA138Y, ALA174Y, ALA711, ALA71Y, ARG1271, ARG127Y, ARG1411, ARG141Y, ARG4231, ARG423Y, ARG4271, ARG427Y, ARG4301, ARG430Y, ARG671, ARG67Y, ARG741, ARG74Y, ASN1391, ASN139Y, ASN4431, ASN443Y, ASP1311, ASP131Y, ASP1371, ASP137Y, ASP2691, ASP269Y, ASP2711, ASP271Y, ASP4241, ASP424Y, GLU1231, GLU123Y, GLU1241, GLU124Y, GLU731, GLU73Y, GLY1251, GLY125Y, GLY1301, GLY130Y, GLY4261, GLY426Y, ILE1421, ILE142Y, ILE4251, ILE425Y, ILE4421, ILE442Y, ILE4711, LEU1331, LEU133Y, LEU4201, LEU4801, LEU480Y, LYS1261, LYS126Y, LYS1401, LYS140Y, LYS1461, LYS146Y, LYS4781, LYS478Y, LYS691, LYS69Y, LYS721, LYS72Y, MET681, MET68Y, PRO1341, PRO134Y, PRO1361, PRO136Y, SER4221, SER422Y, THR1321, THR132Y, THR1351, THR135Y, THR701, THR70Y, TRP4291, TRP429Y, TYR4211, TYR421Y, VAL1281, VAL128Y, VAL1431, VAL143Y, VAL1441, VAL144Y, VAL1451, VAL145Y, VAL4281, VAL428Y, VAL475Y, VAL4821
• Y-2: ALA1292, ALA129Y, ALA2382, ALA238Y, ALA2452, ALA245Y, ALA2482, ALA248Y, ALA2742, ALA274Y, ALA2812, ALA281Y, ALA4172, ALA417Y, ALA4182, ALA418Y, ALA4322, ALA432Y, ALA4342, ALA434Y, ALA4522, ALA452Y, ALA4832, ALA483Y, ARG1412, ARG141Y, ARG2292, ARG229Y, ARG2412, ARG241Y, ARG2852, ARG285Y, ARG4232, ARG423Y, ARG4302, ARG430Y, ARG4642, ARG464Y, ARG672, ARG67Y, ASN1392, ASN139Y, ASN2252, ASN225Y, ASN4102, ASN410Y, ASN4432, ASN443Y, ASN4492, ASN449Y, ASP1312, ASP131Y, ASP1372, ASP137Y, ASP4112, ASP4722, ASP472Y, CYS4812, CYS481Y, GLN2462, GLN246Y, GLN4592, GLN459Y, GLU124Y, GLU1472, GLU147Y, GLU257Y, GLU4132, GLU413Y, GLU4332, GLU433Y, GLU4362, GLU436Y, GLU4502, GLU450Y, GLU4652, GLY1302, GLY130Y, GLY1502, GLY150Y, GLY2402, GLY240Y, GLY2592, GLY259Y, GLY2782, GLY4152, GLY415Y, GLY4382, GLY438Y, GLY4412, GLY441Y, GLY4452, GLY445Y, GLY4552, GLY455Y, GLY4562, GLY456Y, GLY4612, GLY461Y, GLY4632, GLY463Y, GLY466Y, HIS4682, HIS468Y, ILE1422, ILE142Y, ILE1492, ILE149Y, ILE2272, ILE227Y, ILE4252, ILE425Y, ILE4422, ILE442Y, ILE4472, ILE447Y, ILE4772, ILE477Y, LEU1332, LEU133Y, LEU231Y, LEU2422, LEU242Y, LEU2432, LEU243Y, LEU2542, LEU254Y, LEU2562, LEU256Y, LEU2582, LEU258Y, LEU4162, LEU416Y, LEU4202, LEU420Y, LEU4352, LEU435Y, LEU4462, LEU446Y, LEU4622, LEU462Y, LEU4802, LEU480Y, LYS1402, LYS140Y, LYS1462, LYS146Y, LYS2302, LYS230Y, LYS2522, LYS252Y, LYS2532, LYS253Y, LYS4582, LYS458Y, LYS4782, LYS478Y, MET2442, MET244Y, MET4392, MET439Y, PHE4142, PHE414Y, PHE4542, PHE454Y, PRO1342, PRO134Y, PRO1362, PRO136Y, PRO1482, PRO148Y, PRO2262, PRO226Y, PRO2492, PRO249Y, PRO4532, PRO453Y, SER1162, SER116Y, SER2242, SER224Y, SER2362, SER2472, SER247Y, SER4482, SER448Y, SER4602, SER460Y, SER4672, SER467Y, THR1322, THR132Y, THR1352, THR135Y, THR2372, THR237Y, THR2502, THR250Y, THR4122, THR412Y, THR4442, THR444Y, TRP1202, TRP120Y, TRP4292, TRP429Y, TRP632, TRP63Y, TYR4192, TYR419Y, TYR4212, TYR421Y, TYR4372, TYR437Y, TYR4692, TYR469Y, TYR4792, TYR479Y, VAL1432, VAL143Y, VAL1442, VAL144Y, VAL1452, VAL145Y, VAL2282, VAL2512, VAL251Y, VAL2922, VAL292Y, VAL4282, VAL428Y, VAL4312, VAL431Y, VAL4402, VAL440Y, VAL4512, VAL451Y, VAL4572, VAL457Y, VAL4752, VAL475Y, VAL4762, VAL476Y, VAL4822, VAL482Y, VAL4842, VAL484Y
• Z-1: ALA1291, ALA129Z, ALA2381, ALA238Z, ALA2451, ALA245Z, ALA2481, ALA248Z, ALA274Z, ALA2811, ALA281Z, ALA4171, ALA417Z, ALA4181, ALA418Z, ALA4321, ALA432Z, ALA4341, ALA434Z, ALA4521, ALA452Z, ALA4831, ALA483Z, ARG1411, ARG141Z, ARG2291, ARG229Z, ARG2411, ARG241Z, ARG4231, ARG423Z, ARG4301, ARG430Z, ARG4641, ARG464Z, ARG671, ARG67Z, ASN1391, ASN139Z, ASN2251, ASN225Z, ASN4101, ASN410Z, ASN4431, ASN443Z, ASN4491, ASN449Z, ASP1311, ASP131Z, ASP1371, ASP137Z, ASP4721, ASP472Z, ASP4731, ASP473Z, CYS4811, CYS481Z, GLN2461, GLN246Z, GLN4591, GLN459Z, GLN601, GLU1471, GLU147Z, GLU257Z, GLU4131, GLU413Z, GLU4331, GLU433Z, GLU4361, GLU436Z, GLU4501, GLU450Z, GLU4651, GLU465Z, GLY1301, GLY130Z, GLY1501, GLY150Z, GLY2401, GLY240Z, GLY4151, GLY415Z, GLY4381, GLY438Z, GLY4411, GLY441Z, GLY4451, GLY445Z, GLY4551, GLY455Z, GLY4561, GLY456Z, GLY4611, GLY461Z, GLY4631, GLY463Z, HIS4681, HIS468Z, ILE1421, ILE142Z, ILE1491, ILE149Z, ILE2271, ILE227Z, ILE4251, ILE425Z, ILE4421, ILE442Z, ILE4471, ILE447Z, ILE4771, ILE477Z, LEU1331, LEU133Z, LEU2311, LEU231Z, LEU2421, LEU242Z, LEU2431, LEU243Z, LEU2541, LEU254Z, LEU2561, LEU256Z, LEU2581, LEU258Z, LEU4161, LEU416Z, LEU4201, LEU420Z, LEU4351, LEU435Z, LEU4461, LEU446Z, LEU4621, LEU462Z, LEU4801, LEU480Z, LYS1401, LYS140Z, LYS1461, LYS146Z, LYS2301, LYS230Z, LYS2521, LYS252Z, LYS2531, LYS253Z, LYS4581, LYS458Z, LYS4781, LYS478Z, MET2441, MET244Z, MET4391, MET439Z, MET68Z, PHE2331, PHE4141, PHE414Z, PHE4541, PHE454Z, PRO1341, PRO134Z, PRO1361, PRO136Z, PRO1481, PRO148Z, PRO2261, PRO226Z, PRO2491, PRO249Z, PRO4531, PRO453Z, SER1161, SER116Z, SER2471, SER247Z, SER4481, SER448Z, SER4601, SER460Z, SER4671, SER467Z, THR1321, THR132Z, THR1351, THR135Z, THR2231, THR2371, THR237Z, THR2501, THR250Z, THR2551, THR255Z, THR4121, THR412Z, THR4441, THR444Z, TRP1201, TRP120Z, TRP4291, TRP429Z, TRP631, TRP63Z, TYR113Z, TYR4191, TYR419Z, TYR4211, TYR421Z, TYR4371, TYR437Z, TYR4691, TYR469Z, TYR4791, TYR479Z, VAL1431, VAL143Z, VAL1441, VAL144Z, VAL1451, VAL145Z, VAL2281, VAL228Z, VAL2511, VAL251Z, VAL2921, VAL292Z, VAL4281, VAL428Z, VAL4311, VAL431Z, VAL4401, VAL440Z, VAL4511, VAL451Z, VAL4571, VAL457Z, VAL4751, VAL475Z, VAL4761, VAL476Z, VAL4821, VAL482Z, VAL4841, VAL484Z
• Z-2: ALA1292, ALA129Z, ALA1382, ALA138Z, ALA174Z, ALA712, ALA71Z, ARG1272, ARG127Z, ARG1412, ARG141Z, ARG4232, ARG423Z, ARG4272, ARG427Z, ARG4302, ARG430Z, ARG67Z, ARG742, ARG74Z, ASN1392, ASN139Z, ASN4432, ASN443Z, ASP1312, ASP131Z, ASP1372, ASP137Z, ASP2692, ASP269Z, ASP4242, ASP424Z, GLU1232, GLU123Z, GLU1242, GLU124Z, GLU732, GLU73Z, GLY1252, GLY125Z, GLY1302, GLY130Z, GLY4262, GLY426Z, ILE1422, ILE142Z, ILE4252, ILE425Z, ILE4422, ILE442Z, ILE4712, LEU1332, LEU133Z, LEU4202, LEU420Z, LEU4802, LEU480Z, LYS1262, LYS126Z, LYS1402, LYS140Z, LYS1462, LYS146Z, LYS4782, LYS478Z, LYS692, LYS69Z, LYS722, LYS72Z, MET682, MET68Z, PRO1342, PRO134Z, PRO1362, PRO136Z, SER4222, SER422Z, THR1322, THR132Z, THR1352, THR135Z, THR702, THR70Z, TRP4292, TRP429Z, TYR4212, TYR421Z, VAL1282, VAL128Z, VAL1432, VAL143Z, VAL1442, VAL144Z, VAL1452, VAL145Z, VAL4282, VAL428Z, VAL4752, VAL482Z, VAL4842
• 1-2: ALA1121, ALA1122, ALA1151, ALA1152, ALA1221, ALA1222, ALA1291, ALA1292, ALA4341, ALA4831, ALA4832, ALA711, ALA712, ALA751, ALA752, ALA761, ALA762, ARG1271, ARG1272, ARG1411, ARG1412, ARG4271, ARG4272, ARG4301, ARG4302, ARG791, ARG792, ASN4491, ASN4492, ASP4241, ASP831, ASP832, CYS4812, GLU1191, GLU1192, GLU1231, GLU1232, GLU1241, GLU1242, GLU4331, GLU4332, GLU4501, GLU4502, GLY1251, GLY1252, GLY1301, GLY4261, GLY4262, HIS4681, HIS4682, ILE1421, ILE1422, ILE4251, ILE4252, ILE4711, ILE862, LEU1331, LEU4801, LEU4802, LYS1261, LYS1262, LYS1402, LYS721, LYS722, PHE1171, PHE1172, PHE1211, PHE1212, PHE821, PHE822, SER1161, SER1162, SER4671, SER4672, THR1321, THR1322, THR1352, THR701, THR702, TRP1201, TRP1202, TRP4291, TRP4292, TYR1131, TYR1132, VAL1281, VAL1282, VAL1431, VAL1432, VAL4281, VAL4311, VAL4312, VAL4511, VAL4512, VAL4821, VAL4822, VAL4841, VAL4842
• 2-3: ALA3063, ALA3082, ALA3083, ALA3122, ALA3123, ALA3132, ALA3133, ALA3142, ALA3143, ARG3023, ASP2733, ASP3052, ASP3053, ASP3092, ASP3093, GLU3712, GLY3592, GLY3602, LEU2723, LEU3112, LEU3113, LEU3502, LEU3562, LYS3102, LYS3103, LYS3172, LYS3173, LYS3612, MET3572, MET3573, PHE3073, SER3162, SER3163, SER3552, THR3582, THR3583, THR3762, VAL3033, VAL3742
• 3-4: ALA1123, ALA1124, ALA1153, ALA1154, ALA1223, ALA1224, ALA1293, ALA1294, ALA1383, ALA4324, ALA4833, ALA4834, ALA713, ALA714, ALA753, ALA754, ALA763, ALA764, ARG1273, ARG1274, ARG1413, ARG1414, ARG4273, ARG4274, ARG4303, ARG4304, ARG793, ARG794, ASN4493, ASN4494, ASP833, ASP834, GLU1193, GLU1194, GLU1233, GLU1234, GLU1243, GLU1244, GLU4333, GLU4334, GLU4503, GLU4504, GLY1253, GLY1254, GLY1303, GLY1304, GLY4263, GLY4264, HIS4683, HIS4684, ILE1423, ILE1424, ILE4253, ILE4254, ILE863, ILE864, LEU1334, LEU4803, LEU4804, LYS1263, LYS1264, LYS1403, LYS1404, LYS723, LYS724, PHE1173, PHE1174, PHE1213, PHE1214, PHE823, PHE824, SER1163, SER1164, SER4673, SER4674, THR1323, THR1324, THR1353, THR703, TRP1203, TRP1204, TRP4293, TRP4294, TYR1133, TYR1134, TYR4693, TYR4694, VAL1283, VAL1284, VAL1433, VAL1434, VAL4283, VAL4284, VAL4313, VAL4314, VAL4513, VAL4514, VAL4823, VAL4824, VAL4843, VAL4844
• 3-5: ALA1383, ALA715, ARG1413, ARG4233, ARG4235, ARG4273, ARG4275, ARG675, ARG745, ASN1393, ASP1313, ASP1315, ASP1373, ASP2693, ASP2695, ASP4243, ASP4245, GLU735, GLY1303, GLY1305, ILE4253, ILE4255, LYS1403, LYS695, LYS725, MET685, PRO1343, PRO1363, THR1323, THR1325, THR1353, THR705, VAL1443
• 3-6: ALA4323, ALA4326, ALA4833, ALA4836, ARG2293, ARG2296, ARG2413, ARG2416, ARG673, ASN4493, ASP1313, ASP1316, ASP4723, ASP4726, CYS4813, CYS4816, GLN4596, GLU1473, GLU1476, GLU4333, GLU4336, GLU4363, GLU4366, GLY4383, GLY4386, HIS4683, HIS4686, ILE4423, ILE4426, ILE4473, LEU4353, LEU4356, LEU4463, LEU4466, LYS1403, LYS1406, LYS1463, LYS4583, LYS4586, LYS4783, LYS4786, PRO2493, PRO2496, THR2503, TYR4696, TYR4793, TYR4796, VAL4403, VAL4406
• 4-5: ALA4324, ALA4325, ALA4344, ALA4834, ALA4835, ARG2294, ARG2295, ARG2415, ARG675, ASN4104, ASP1314, ASP1315, ASP4724, ASP4725, CYS4814, CYS4815, GLN4594, GLN605, GLU1474, GLU1475, GLU4334, GLU4335, GLU4364, GLU4365, GLY4384, GLY4385, HIS4684, HIS4685, ILE4424, ILE4425, LEU4354, LEU4355, LEU4464, LEU4465, LYS1404, LYS1405, LYS4584, LYS4585, LYS4784, LYS4785, PRO2494, THR2505, TRP635, TYR4794, TYR4795, VAL4404, VAL4405, VAL4574
• 4-6: ARG4234, ARG4236, ARG4274, ARG4276, ASP1314, ASP1316, ASP1374, ASP1376, ASP2694, ASP2696, ASP4244, ASP4246, GLY1304, GLY1306, ILE4254, ILE4256, LYS724, LYS726, THR1324, THR1326
• 5-6: ARG1275, ARG1276, ARG1415, ARG1416, ARG795, ARG796, GLU1195, GLU1196, GLU1235, GLU1236, GLU1245, GLU1246, GLU4335, GLU4336, GLU4505, GLU4506, HIS4685, HIS4686, LYS1265, LYS1266, LYS725, LYS726, TRP1205, TRP1206