3IAM

crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus, reduced, 2 mol/asu, with bound nadh

• Total interactions analyzed: 120
• Total true interactions: 35
• Strongest Interaction:
  • Chains: 4-7
  • Int. Res.: 29
  • Norm. En. per Res.: -4.9678
• Hub Node: 3(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
1-2	-144.3359	-144.1769	-704.496	-993.0088	229	43	16	28084	13	79	77
1-3	-41.8383	-41.4884	-329.606	-412.9327	148	22	7	15371	5	47	55
1-7	0.0	3.1105	-22.2791	-19.1686	25	0	1	1257	0	3	16
2-3	-12.0049	68.6265	-155.25	-98.6284	58	6	0	5426	2	16	17
2-7	-37.9471	-58.8617	-143.174	-239.9828	83	13	8	7044	4	25	18
3-4	0.0	3.2693	-248.904	-245.6347	88	26	5	10634	1	20	21
3-5	-35.7158	-18.3868	-233.494	-287.5966	98	12	2	8848	4	26	26
3-9	-32.3232	-98.8618	-141.81	-272.995	59	11	1	5885	6	30	24
3-7	-32.5182	-7.8904	-230.145	-270.5536	92	17	4	9321	8	52	61
3-D	0.0	0.0	-2.8193	-2.8193	8	0	0	268	0	5	3
4-5	-210.2269	-44.3973	-732.023	-986.6472	236	55	15	30724	16	84	83
4-6	-21.3143	-38.5681	-267.627	-327.5094	110	14	5	11158	5	17	25
4-9	-40.5507	-48.9742	-267.602	-357.1269	98	7	5	10611	4	40	21
4-7	-15.0401	-57.1608	-71.8664	-144.0673	29	5	1	2780	3	9	13
5-6	-24.707	-4.8326	-81.7006	-111.2402	49	2	1	3472	0	12	5
5-9	-15.1076	-54.1935	-167.749	-237.0501	57	6	6	6330	7	12	12
6-9	-73.7996	-24.6111	-340.102	-438.5127	118	45	15	14594	3	35	42
9-7	-7.1335	28.5049	-93.8008	-72.4294	63	7	3	4627	0	22	24
A-B	-131.2697	-142.4979	-714.89	-988.6576	230	38	16	28148	15	78	77
A-C	-40.3079	-39.6553	-328.751	-408.7142	147	18	7	15351	5	48	55
A-H	0.0	3.0196	-21.4086	-18.389	24	0	1	1213	0	3	16
B-C	-20.3305	68.144	-152.39	-104.5765	58	9	0	5482	2	16	17
B-H	-38.3317	-58.9222	-143.809	-241.0629	82	11	8	7070	4	25	18
C-D	0.0	3.6018	-253.959	-250.3572	89	32	5	10756	1	20	21
C-E	-34.013	-21.3794	-242.746	-298.1384	99	13	2	9020	4	26	27
C-G	-34.1977	-87.9802	-145.911	-268.0889	61	10	1	5999	6	30	24
C-H	-26.8786	-9.5521	-225.689	-262.1197	91	17	4	9377	8	52	61
D-E	-187.7776	-62.5526	-727.539	-977.8692	236	58	15	30644	16	83	84
D-F	-14.0496	-37.3847	-260.525	-311.9593	108	12	5	10886	4	17	24
D-G	-45.2771	-49.2557	-273.569	-368.1018	99	9	5	10749	4	41	21
D-H	-13.206	-55.1087	-72.1179	-140.4325	29	6	1	2816	3	10	13
E-F	-22.5497	-4.7482	-76.418	-103.716	50	2	1	3370	0	12	5
E-G	-14.2855	-53.2063	-169.44	-236.9318	57	7	6	6353	6	12	12
F-G	-79.5799	-15.4009	-357.399	-452.3799	118	59	15	15042	3	37	44
G-H	-9.074	29.5201	-104.399	-83.9529	63	7	3	4874	0	24	25

Interface residues

• 1-2: ALA1312, ALA1411, ALA1421, ALA1482, ALA162, ALA1771, ALA1791, ALA1871, ALA191, ALA1971, ALA252, ALA262, ALA2801, ALA3401, ALA642, ALA842, ALA912, ALA932, ARG1041, ARG1351, ARG1391, ARG1401, ARG1441, ARG1472, ARG1492, ARG1531, ARG1751, ARG1961, ARG232, ARG242, ARG2601, ARG322, ARG3341, ARG3461, ARG4331, ARG4381, ASN1372, ASN1901, ASN1981, ASN3431, ASP1031, ASP1091, ASP1382, ASP1431, ASP1701, ASP3391, ASP982, CYS1242, CYS1282, CYS1442, CYS1821, CYS3531, CYS882, GLN1202, GLN1352, GLN2531, GLN352, GLN362, GLN712, GLN812, GLN861, GLU1081, GLU1232, GLU132, GLU1371, GLU1392, GLU1432, GLU1461, GLU1512, GLU1642, GLU1782, GLU1802, GLU1931, GLU212, GLU2651, GLU2851, GLU3511, GLU592, GLU942, GLU951, GLU952, GLU971, GLY1262, GLY1361, GLY1732, GLY1761, GLY1781, GLY1941, GLY2131, GLY221, GLY222, GLY2561, GLY2621, GLY2811, GLY2941, GLY3271, GLY3541, GLY622, GLY922, GLY991, HIS1292, HIS1721, HIS1741, HIS1742, HIS1752, HIS1772, HIS201, HIS3501, ILE1321, ILE1342, ILE1811, ILE2541, ILE272, ILE2871, ILE2901, ILE2911, ILE3291, ILE3311, ILE412, LEU1002, LEU1252, LEU1502, LEU1542, LEU1632, LEU1711, LEU1881, LEU1921, LEU1951, LEU2111, LEU2511, LEU2841, LEU302, LEU312, LEU3301, LEU3441, LEU4361, LEU862, LEU902, LEU962, LYS1021, LYS1212, LYS1501, LYS172, LYS2141, LYS231, LYS2591, LYS3551, LYS892, MET1891, MET282, MET3371, MET3411, MET612, PHE1011, PHE3471, PHE662, PRO1322, PRO1402, PRO192, PRO1991, PRO202, PRO2571, PRO2611, PRO292, PRO2991, PRO3321, PRO4321, PRO4341, PRO981, SER1001, SER1272, SER1911, SER2551, SER261, SER2951, SER3361, SER3521, SER4351, SER652, SER682, SER872, SER961, THR1302, THR142, THR1462, THR3451, THR552, THR582, THR852, TRP2121, TRP271, TRP2791, TRP3421, TRP4371, TRP972, TYR1051, TYR1311, TYR1331, TYR1381, TYR1412, TYR1801, TYR181, TYR182, TYR2641, TYR3481, TYR672, TYR692, TYR702, TYR881, TYR992, VAL1222, VAL1291, VAL1332, VAL1341, VAL1452, VAL1731, VAL1762, VAL1792, VAL211, VAL2581, VAL2631, VAL3281, VAL3351, VAL3381, VAL4311, VAL532, VAL602, VAL632, VAL822
• 1-3: ALA1033, ALA1053, ALA1771, ALA1791, ALA1971, ALA3491, ALA3641, ALA3721, ALA3891, ALA4031, ALA443, ALA803, ALA813, ALA863, ARG1013, ARG1563, ARG1623, ARG1893, ARG1961, ARG2001, ARG2053, ARG3601, ARG3971, ARG4403, ARG463, ASN1143, ASN1901, ASN1981, ASN3691, ASN3861, ASP2013, ASP3831, ASP4041, ASP983, CYS1813, CYS1821, CYS1843, CYS343, CYS3531, CYS3561, CYS3591, CYS4001, CYS453, CYS833, GLN1043, GLN2081, GLN3781, GLU1023, GLU1093, GLU1583, GLU1931, GLU1983, GLU2043, GLU3511, GLU3611, GLU3801, GLU3851, GLU3951, GLU4393, GLY1063, GLY1781, GLY1941, GLY2063, GLY2131, GLY3541, GLY3621, GLY3651, GLY3791, GLY3961, GLY433, HIS1153, HIS1833, HIS2083, HIS3501, ILE1811, ILE1823, ILE2033, ILE3741, ILE3941, ILE423, LEU1123, LEU1133, LEU1951, LEU2011, LEU3701, LEU3871, LEU3901, LEU3911, LEU3931, LEU4021, LEU4353, LEU493, LEU793, LYS1853, LYS2021, LYS3551, LYS3731, LYS3821, LYS4383, LYS783, MET1073, MET3671, MET473, PHE1103, PHE1573, PHE1593, PHE2023, PHE2103, PHE333, PHE3471, PHE3661, PHE3711, PHE3991, PRO1991, PRO2031, PRO2041, PRO3581, PRO3921, PRO4011, PRO413, PRO4423, PRO773, SER2091, SER3521, SER3981, SER403, THR1113, THR1553, THR1603, THR2093, THR3571, THR853, TRP2121, TRP4081, TYR1403, TYR1801, TYR3481, VAL1003, VAL1083, VAL1533, VAL1883, VAL2073, VAL3631, VAL3681, VAL4071, VAL503, VAL843, VAL993
• 1-7: ALA3721, ARG817, ASN3691, ASP3831, GLN3781, GLU3801, GLY3751, GLY3771, GLY3791, HIS3501, HIS907, HIS927, HIS947, ILE3741, LEU3701, LEU797, LYS3731, LYS3821, LYS4281, LYS787, LYS807, PHE3711, THR3761, TRP3421, VAL3681
• 2-3: ALA502, ALA642, ARG1783, ARG2053, ARG242, ARG422, ARG4403, ARG452, ASP1973, ASP2013, ASP2153, GLU1232, GLU1923, GLU1983, GLU2043, GLU212, GLU442, GLU472, GLU482, GLU592, GLY1963, GLY2063, GLY2123, GLY542, GLY622, ILE2033, ILE2113, ILE412, ILE462, LEU2003, LEU2183, LYS1853, MET2143, MET612, PHE1913, PHE2023, PHE2103, PHE2163, PHE662, PHE722, PRO2193, PRO432, PRO4423, PRO572, SER652, SER682, THR2093, THR2133, THR552, THR562, THR582, TYR672, TYR692, VAL1222, VAL1883, VAL1993, VAL602, VAL632
• 2-7: ALA1177, ALA1197, ALA1227, ALA1257, ALA1277, ALA1297, ALA642, ALA897, ARG1147, ARG1217, ARG1237, ARG422, ARG887, ASP1207, ASP982, GLN1202, GLN352, GLN712, GLU1022, GLU1102, GLU1247, GLU442, GLU472, GLU657, GLU942, GLU952, GLY1052, GLY1067, GLY1072, GLY1092, GLY1152, GLY622, GLY762, HIS792, HIS907, HIS927, HIS947, ILE1062, ILE1087, ILE412, ILE462, ILE917, LEU1002, LEU1042, LEU1107, LEU1187, LEU1267, LEU847, LEU867, LEU937, LYS1077, MET612, PHE1157, PHE1172, PHE1287, PHE662, PHE677, PHE722, PRO1082, PRO1097, PRO432, PRO572, PRO742, PRO877, SER1182, SER652, SER682, THR1012, THR1032, THR1057, THR1117, THR1122, THR582, THR752, TRP402, TRP972, TYR672, TYR692, TYR702, TYR992, VAL1112, VAL1192, VAL732
• 3-4: ALA1053, ALA1273, ALA3234, ARG1333, ARG1563, ARG1613, ARG1803, ARG2453, ARG3034, ARG93, ASN1143, ASN2463, ASN3064, ASP1183, ASP1323, ASP3044, CYS1193, CYS1223, CYS1283, GLN1313, GLN3084, GLU1093, GLU1293, GLU1363, GLU1413, GLU1503, GLU1583, GLU2483, GLU3184, GLU3224, GLU3334, GLY1064, GLY1253, GLY1263, GLY1383, GLY3344, HIS1153, HIS3154, HIS3274, HIS3304, HIS3364, ILE3094, ILE3254, LEU1123, LEU1133, LEU1173, LEU1303, LEU1393, LEU1513, LEU3164, LEU3174, LYS1243, LYS3294, LYS3394, MET3214, PHE1103, PHE1573, PHE3284, PHE3354, PRO1163, PRO1203, PRO1523, PRO3014, PRO3054, PRO3074, PRO3114, PRO3124, PRO3134, SER3204, THR1113, THR1213, THR1343, THR1553, THR3104, THR3194, THR3324, TRP2473, TYR1373, TYR1403, TYR1433, TYR1543, TYR3264, VAL1083, VAL1084, VAL1353, VAL1533, VAL2323, VAL3244
• 3-5: ALA1273, ALA1685, ALA1725, ALA1735, ALA2443, ARG1013, ARG1333, ARG1635, ARG1715, ARG1863, ARG1895, ARG1935, ARG2453, ARG2703, ARG2763, ARG2783, ARG93, ASN2463, ASP1323, ASP2283, ASP2683, ASP293, CYS1283, CYS2303, GLN1043, GLN1313, GLU1293, GLU1363, GLU1413, GLU1615, GLU1695, GLU2483, GLU2503, GLU2513, GLU2733, GLU2813, GLU363, GLU6303, GLY1253, GLY1263, GLY1383, GLY1625, GLY1805, GLY1865, GLY1875, GLY1915, GLY2723, GLY273, HIS4283, ILE1655, ILE1665, ILE2293, ILE2883, ILE6293, LEU1303, LEU1393, LEU1745, LEU1815, LEU1955, LEU323, LEU963, LYS1243, LYS1855, LYS1905, LYS373, MET203, MET2493, MET473, PHE1595, PHE1705, PHE1835, PHE243, PHE333, PHE4323, PRO1795, PRO2313, PRO2533, PRO313, PRO6283, SER1885, SER1945, SER2713, SER353, THR1343, THR1825, THR2523, THR2693, TRP1965, TRP2473, TYR1373, TYR1433, TYR1645, TYR1845, TYR1925, TYR283, VAL1353, VAL233, VAL303
• 3-9: ALA1079, ALA2443, ALA609, ALA619, ALA629, ALA739, ALA839, ARG1803, ARG2413, ARG2433, ARG2453, ARG2703, ARG869, ASN2463, ASN759, ASP1183, ASP1233, ASP1773, CYS1089, CYS1193, CYS1223, CYS569, CYS599, GLN1313, GLU2483, GLU2733, GLU719, GLU749, GLU859, GLY1253, GLY2723, GLY559, GLY849, HIS1673, ILE1753, ILE549, ILE689, LEU2363, LEU2383, LEU2753, LEU589, LYS1243, LYS1663, LYS899, PHE2423, PRO1099, PRO1203, PRO1693, PRO729, PRO779, SER2713, SER579, THR1109, THR1213, TRP2473, TYR669, TYR699, TYR879, VAL709
• 3-7: ALA1277, ALA1297, ALA357, ALA577, ALA707, ALA777, ALA897, ARG1613, ARG1623, ARG1783, ARG2053, ARG307, ARG817, ARG857, ARG887, ASP1183, ASP1653, ASP1773, ASP2153, ASP367, ASP397, ASP617, ASP717, CYS1193, CYS1223, GLU1583, GLU1793, GLU2043, GLU327, GLU347, GLU657, GLY2123, GLY2173, GLY627, GLY647, GLY837, HIS1153, HIS1633, HIS1673, HIS1683, HIS2083, HIS767, HIS907, HIS927, HIS947, ILE2033, ILE2113, ILE417, ILE827, ILE917, LEU1173, LEU1267, LEU1703, LEU1763, LEU637, LEU687, LEU697, LEU797, LEU867, LEU937, LYS1663, LYS337, LYS787, LYS807, MET2143, MET557, PHE1287, PHE1573, PHE1593, PHE2103, PHE2163, PHE377, PHE407, PRO1163, PRO1203, PRO1693, PRO387, PRO667, PRO747, PRO877, SER587, SER607, SER737, THR1213, THR1603, THR2093, THR2133, THR567, TYR427, VAL1643, VAL2073, VAL727
• 3-D: ARG33, GLU51D, GLY387D, ILE103, LEU53D, LYS386D, SER48D, VAL52D
• 4-5: ALA1004, ALA1074, ALA1115, ALA1685, ALA1725, ALA1735, ALA2294, ALA2514, ALA3724, ALA505, ALA695, ARG1165, ARG1335, ARG1475, ARG1715, ARG1895, ARG1935, ARG2404, ARG2694, ARG3674, ARG3714, ARG4094, ARG424, ARG645, ARG675, ARG734, ARG875, ARG915, ASN1125, ASN205, ASN245, ASN2454, ASN3064, ASN3774, ASN475, ASP1065, ASP1205, ASP1315, ASP1495, ASP1785, ASP2314, ASP2474, ASP3044, ASP3604, ASP4064, ASP4084, ASP515, ASP565, ASP625, ASP845, GLN3084, GLN3794, GLN774, GLU1024, GLU1155, GLU1175, GLU1395, GLU1545, GLU185, GLU2274, GLU3334, GLU3414, GLU3524, GLU674, GLU714, GLU735, GLY1064, GLY1095, GLY1535, GLY1765, GLY1805, GLY1875, GLY1915, GLY215, GLY2334, GLY235, GLY2434, GLY3344, GLY3404, GLY3544, GLY3614, GLY3624, GLY545, GLY604, GLY654, GLY795, GLY855, HIS1295, HIS1445, HIS3364, HIS584, HIS634, HIS724, ILE1355, ILE2304, ILE3094, ILE3574, ILE525, ILE594, LEU1044, LEU1054, LEU1075, LEU1145, LEU1215, LEU1365, LEU1415, LEU1465, LEU1525, LEU1745, LEU1815, LEU1955, LEU225, LEU2324, LEU2344, LEU2394, LEU255, LEU2664, LEU3534, LEU3784, LEU3814, LEU414, LEU495, LEU555, LEU585, LEU624, LEU745, LEU775, LEU994, LYS1034, LYS1345, LYS1485, LYS1775, LYS1855, LYS1905, LYS2504, LYS3294, LYS3394, LYS3694, LYS425, LYS684, LYS815, MET15, MET3644, MET4044, MET444, MET704, PHE1135, PHE1225, PHE1705, PHE3284, PHE3354, PHE3754, PHE465, PHE485, PHE664, PHE885, PHE895, PRO1385, PRO1455, PRO1515, PRO1675, PRO2254, PRO2264, PRO3074, PRO3374, PRO3384, PRO3454, PRO3654, PRO3734, PRO3824, PRO574, PRO615, PRO785, SER1105, SER1885, SER1945, SER2424, SER3594, SER3634, SER3744, SER3804, SER765, SER865, THR1055, THR1375, THR1575, THR1755, THR1825, THR2354, THR3104, THR3324, THR3464, THR595, THR644, THR694, THR744, TRP1085, TRP1965, TRP265, TRP805, TYR1505, TYR1925, TYR2464, TYR2524, TYR3264, TYR3314, TYR3434, TYR3554, TYR3564, TYR3664, TYR575, TYR605, TYR614, TYR725, TYR754, TYR814, TYR935, VAL1014, VAL1084, VAL1185, VAL2284, VAL2444, VAL2484, VAL3424, VAL3444, VAL3584, VAL3684, VAL3704, VAL3764, VAL4074, VAL535, VAL554, VAL564, VAL705, VAL715, VAL755
• 4-6: ALA1106, ALA1226, ALA446, ALA476, ALA526, ALA566, ALA816, ALA896, ARG1436, ARG1534, ARG1674, ARG3504, ARG4094, ARG424, ARG734, ARG836, ARG844, ARG946, ASN1196, ASN1206, ASN1714, ASN294, ASN784, ASP1584, ASP4064, ASP4084, ASP556, ASP864, CYS1116, CYS1406, CYS456, CYS466, GLN1256, GLN1664, GLN774, GLU1456, GLU1544, GLU1614, GLU496, GLU674, GLY1156, GLY1166, GLY1396, GLY1654, GLY314, GLY394, GLY4054, GLY426, GLY604, GLY654, GLY826, HIS1694, HIS1704, HIS584, HIS634, HIS724, ILE1236, ILE486, ILE594, ILE794, LEU1384, LEU1574, LEU414, LEU436, LEU624, LEU846, LEU884, LYS684, LYS866, LYS876, MET1176, MET4044, MET506, MET516, MET704, MET854, MET886, MET926, PHE1186, PHE1464, PHE1474, PHE1504, PHE1684, PHE416, PHE664, PRO1416, PRO1426, PRO1446, PRO574, PRO834, PRO906, SER1284, SER536, SER856, SER904, THR1354, THR546, THR644, THR694, THR804, THR824, TYR1216, TYR614, TYR814, TYR874, VAL1246, VAL1314, VAL4034, VAL404, VAL916
• 4-9: ALA1079, ALA1129, ALA329, ALA609, ALA619, ALA629, ALA659, ARG1674, ARG1679, ARG1744, ARG3034, ARG3144, ARG369, ARG734, ARG844, ARG869, ARG979, ASN1714, ASN784, ASP1584, ASP1814, CYS1019, CYS1049, CYS1089, CYS569, CYS599, CYS639, CYS989, GLN1664, GLN774, GLU1059, GLU1069, GLU1544, GLU1614, GLU1699, GLU1804, GLU1844, GLU1854, GLU1894, GLU3184, GLU3334, GLY1029, GLY1119, GLY1654, GLY399, HIS1694, HIS1704, HIS3274, HIS3304, HIS389, HIS724, ILE1139, ILE794, ILE999, LEU1039, LEU1159, LEU1574, LEU1594, LEU1824, LEU3174, LEU339, LEU589, LEU764, LYS1794, LYS3294, LYS349, MET3644, PHE1009, PHE1604, PHE1864, PHE3284, PHE379, PRO1099, PRO1649, PRO1834, PRO3114, PRO359, PRO649, PRO834, SER579, THR1109, THR1554, THR1644, THR3324, THR694, THR744, THR804, TRP1624, TYR1179, TYR1659, TYR1724, TYR3314, TYR669, TYR814, VAL1149, VAL1634, VAL319, VAL3244
• 4-7: ALA777, ARG3144, ARG437, ARG467, ARG757, ASP397, GLU3184, GLU457, HIS3154, HIS3274, HIS767, ILE417, LEU3164, LEU3174, MET3214, MET447, PHE3284, PHE377, PHE407, PRO3124, PRO3134, PRO387, PRO477, PRO747, SER3204, THR3194, TYR427, TYR487, VAL3244
• 5-6: ALA1226, ALA1685, ALA896, ARG1165, ARG1335, ARG1605, ARG1715, ASN1196, ASN1206, ASN1266, ASP1205, ASP1405, GLN1256, GLU1395, GLU1545, GLU1656, GLY1156, GLY1166, GLY1535, HIS1445, ILE1236, ILE1355, ILE1655, ILE1665, LEU1215, LEU1365, LEU1415, LEU1465, LEU1525, LEU1585, LYS1345, LYS866, LYS876, MET1176, MET886, PHE1186, PRO1385, PRO1455, PRO1515, PRO1565, PRO1675, PRO906, SER1146, SER856, THR1375, THR1555, THR1575, TYR1216, TYR1505
• 5-9: ALA1685, ALA1725, ALA1735, ALA609, ALA619, ALA629, ALA659, ALA679, ARG1479, ARG1605, ARG1635, ARG1715, ARG979, ASN949, ASP1289, ASP1359, CYS599, CYS639, GLU1349, GLU1545, GLU1615, GLU719, GLU929, GLY1329, GLY1625, ILE1655, ILE1665, ILE689, ILE939, LEU1299, LEU1525, LEU1585, LEU589, LEU969, LYS1339, LYS1449, LYS899, MET1369, MET959, PHE1595, PHE1705, PRO1565, PRO1675, PRO649, SER1279, SER579, THR1555, THR1575, TYR1269, TYR1319, TYR1645, TYR669, TYR699, TYR919, VAL1309, VAL709, VAL909
• 6-9: ALA1106, ALA1126, ALA1229, ALA1466, ALA1506, ALA1509, ALA1626, ALA299, ALA329, ALA566, ALA659, ALA679, ARG1436, ARG1479, ARG1489, ARG1529, ARG1666, ARG1696, ARG409, ARG836, ARG979, ASN1196, ASN1206, ASN1266, ASN1646, ASN949, ASP1239, ASP1286, ASP1289, ASP1346, ASP1359, ASP289, CYS1019, CYS1116, CYS1406, CYS639, CYS989, GLN1256, GLN1469, GLN1536, GLN1556, GLN1616, GLU1209, GLU1259, GLU1456, GLU1499, GLU1656, GLU1686, GLY1096, GLY1156, GLY1166, GLY1396, GLY1609, GLY1676, GLY399, HIS389, HIS419, ILE1066, ILE1236, ILE1486, ILE999, LEU1039, LEU1299, LEU1476, LEU1546, LEU1706, LEU339, LEU969, LYS1449, LYS1519, LYS1566, LYS1576, LYS1589, LYS349, MET1086, MET1176, MET1219, MET1526, MET959, PHE1009, PHE1186, PHE1199, PHE379, PRO1386, PRO1416, PRO1426, PRO1446, PRO1459, PRO1716, PRO279, PRO309, PRO649, SER1076, SER1136, SER1146, SER1279, THR1439, THR1539, TYR1179, TYR1249, TYR1269, TYR1319, TYR1366, TYR1496, TYR1619, TYR1636, TYR269, TYR669, VAL1246, VAL1276, VAL1309, VAL1336, VAL1356, VAL1376, VAL1516, VAL1579, VAL1586, VAL319
• 9-7: ALA1079, ALA1129, ALA357, ALA839, ARG1679, ARG307, ARG437, ARG459, ARG467, ARG869, ASN489, ASN759, ASP367, ASP397, ASP497, ASP769, CYS1089, CYS539, CYS569, GLN257, GLU1059, GLU1069, GLU1699, GLU1719, GLU327, GLU347, GLU457, GLU519, GLU789, GLU859, GLY1119, GLY499, GLY849, HIS469, ILE417, ILE547, ILE549, LEU1709, LEU507, LEU509, LEU589, LYS337, LYS529, MET447, PHE317, PHE377, PHE407, PRO1099, PRO1689, PRO387, PRO477, PRO479, PRO517, PRO779, PRO809, SER829, THR1109, THR449, THR527, THR537, TYR427, TYR487, VAL1149
• A-B: ALA131B, ALA141A, ALA142A, ALA148B, ALA16B, ALA177A, ALA179A, ALA187A, ALA197A, ALA19A, ALA25B, ALA26B, ALA280A, ALA340A, ALA64B, ALA84B, ALA91B, ALA93B, ARG104A, ARG135A, ARG139A, ARG140A, ARG144A, ARG147B, ARG149B, ARG153A, ARG175A, ARG196A, ARG23B, ARG24B, ARG260A, ARG32B, ARG334A, ARG346A, ARG433A, ARG438A, ASN137B, ASN190A, ASN198A, ASN343A, ASP103A, ASP109A, ASP138B, ASP143A, ASP170A, ASP339A, ASP98B, CYS124B, CYS128B, CYS144B, CYS182A, CYS353A, CYS83B, CYS88B, GLN120B, GLN135B, GLN253A, GLN288A, GLN35B, GLN36B, GLN81B, GLN86A, GLU108A, GLU123B, GLU137A, GLU139B, GLU13B, GLU143B, GLU146A, GLU151B, GLU164B, GLU178B, GLU180B, GLU193A, GLU21B, GLU265A, GLU285A, GLU351A, GLU59B, GLU94B, GLU95A, GLU95B, GLU97A, GLY126B, GLY136A, GLY173B, GLY176A, GLY178A, GLY194A, GLY213A, GLY22A, GLY22B, GLY256A, GLY262A, GLY281A, GLY294A, GLY327A, GLY354A, GLY62B, GLY92B, GLY99A, HIS129B, HIS172A, HIS174A, HIS174B, HIS175B, HIS177B, HIS20A, HIS350A, ILE132A, ILE134B, ILE181A, ILE254A, ILE27B, ILE287A, ILE290A, ILE291A, ILE329A, ILE331A, ILE41B, LEU100B, LEU125B, LEU150B, LEU154B, LEU163B, LEU171A, LEU188A, LEU192A, LEU195A, LEU211A, LEU251A, LEU284A, LEU30B, LEU31B, LEU330A, LEU344A, LEU436A, LEU86B, LEU90B, LEU96B, LYS102A, LYS121B, LYS150A, LYS17B, LYS214A, LYS23A, LYS259A, LYS355A, LYS89B, MET189A, MET28B, MET337A, MET341A, MET61B, PHE101A, PHE347A, PHE66B, PRO132B, PRO140B, PRO199A, PRO19B, PRO20B, PRO257A, PRO261A, PRO299A, PRO29B, PRO332A, PRO432A, PRO434A, PRO98A, SER100A, SER127B, SER191A, SER255A, SER26A, SER295A, SER336A, SER352A, SER435A, SER65B, SER68B, SER87B, SER96A, THR130B, THR146B, THR14B, THR345A, THR55B, THR58B, THR85B, TRP212A, TRP279A, TRP27A, TRP342A, TRP437A, TRP97B, TYR105A, TYR131A, TYR133A, TYR138A, TYR141B, TYR180A, TYR18A, TYR18B, TYR264A, TYR348A, TYR67B, TYR69B, TYR70B, TYR88A, TYR99B, VAL122B, VAL129A, VAL133B, VAL134A, VAL145B, VAL173A, VAL176B, VAL179B, VAL21A, VAL258A, VAL263A, VAL328A, VAL335A, VAL338A, VAL431A, VAL53B, VAL60B, VAL63B, VAL82B
• A-C: ALA103C, ALA105C, ALA177A, ALA179A, ALA197A, ALA349A, ALA364A, ALA372A, ALA389A, ALA403A, ALA44C, ALA80C, ALA81C, ALA86C, ARG101C, ARG156C, ARG162C, ARG189C, ARG196A, ARG200A, ARG205C, ARG360A, ARG397A, ARG440C, ARG46C, ASN114C, ASN190A, ASN198A, ASN369A, ASN386A, ASP201C, ASP383A, ASP404A, ASP98C, CYS181C, CYS182A, CYS184C, CYS34C, CYS353A, CYS356A, CYS359A, CYS400A, CYS45C, CYS83C, GLN104C, GLN208A, GLN378A, GLU102C, GLU109C, GLU158C, GLU193A, GLU198C, GLU204C, GLU351A, GLU361A, GLU380A, GLU385A, GLU395A, GLU439C, GLY106C, GLY178A, GLY194A, GLY206C, GLY213A, GLY354A, GLY362A, GLY365A, GLY379A, GLY396A, GLY43C, HIS115C, HIS183C, HIS208C, HIS350A, ILE181A, ILE182C, ILE203C, ILE374A, ILE394A, ILE42C, LEU112C, LEU113C, LEU195A, LEU201A, LEU370A, LEU387A, LEU390A, LEU391A, LEU393A, LEU402A, LEU435C, LEU49C, LEU79C, LYS185C, LYS202A, LYS355A, LYS373A, LYS382A, LYS438C, LYS78C, MET107C, MET367A, MET47C, PHE110C, PHE157C, PHE159C, PHE202C, PHE210C, PHE33C, PHE347A, PHE366A, PHE371A, PHE399A, PRO199A, PRO203A, PRO204A, PRO358A, PRO392A, PRO401A, PRO41C, PRO442C, PRO77C, SER209A, SER352A, SER398A, SER40C, THR111C, THR155C, THR160C, THR209C, THR357A, THR85C, TRP212A, TRP408A, TYR140C, TYR180A, TYR348A, VAL100C, VAL108C, VAL153C, VAL188C, VAL207C, VAL363A, VAL368A, VAL50C, VAL84C, VAL99C
• A-H: ALA372A, ARG81H, ASN369A, ASP383A, GLN378A, GLU380A, GLY375A, GLY379A, HIS350A, HIS90H, HIS92H, HIS94H, ILE374A, LEU370A, LEU79H, LYS373A, LYS382A, LYS428A, LYS78H, LYS80H, PHE371A, THR376A, TRP342A, VAL368A
• B-C: ALA50B, ALA64B, ARG178C, ARG205C, ARG24B, ARG42B, ARG440C, ARG45B, ASP197C, ASP201C, ASP215C, GLU123B, GLU192C, GLU198C, GLU204C, GLU21B, GLU44B, GLU47B, GLU48B, GLU59B, GLY196C, GLY206C, GLY212C, GLY54B, GLY62B, ILE203C, ILE211C, ILE41B, ILE46B, LEU200C, LEU218C, LYS185C, MET214C, MET61B, PHE191C, PHE202C, PHE210C, PHE216C, PHE66B, PHE72B, PRO219C, PRO43B, PRO442C, PRO57B, SER65B, SER68B, THR209C, THR213C, THR55B, THR56B, THR58B, TYR67B, TYR69B, VAL122B, VAL188C, VAL199C, VAL60B, VAL63B
• B-H: ALA117H, ALA119H, ALA122H, ALA125H, ALA127H, ALA129H, ALA64B, ALA89H, ARG114H, ARG121H, ARG123H, ARG42B, ARG88H, ASP120H, ASP98B, GLN120B, GLN35B, GLN71B, GLU102B, GLU110B, GLU124H, GLU44B, GLU47B, GLU65H, GLU94B, GLU95B, GLY105B, GLY106H, GLY107B, GLY109B, GLY115B, GLY62B, GLY76B, HIS79B, HIS90H, HIS92H, HIS94H, ILE106B, ILE108H, ILE41B, ILE46B, ILE91H, LEU100B, LEU104B, LEU110H, LEU118H, LEU126H, LEU86H, LEU93H, LYS107H, MET61B, PHE115H, PHE117B, PHE128H, PHE66B, PHE67H, PHE72B, PRO108B, PRO109H, PRO113B, PRO43B, PRO57B, PRO74B, PRO87H, SER118B, SER65B, SER68B, THR101B, THR103B, THR105H, THR112B, THR58B, THR75B, TRP40B, TRP97B, TYR67B, TYR69B, TYR70B, TYR99B, VAL111B, VAL119B, VAL73B
• C-D: ALA105C, ALA127C, ALA323D, ARG133C, ARG156C, ARG161C, ARG180C, ARG245C, ARG303D, ARG9C, ASN114C, ASN246C, ASN306D, ASP118C, ASP132C, ASP304D, CYS119C, CYS122C, CYS128C, GLN131C, GLN308D, GLU109C, GLU129C, GLU136C, GLU141C, GLU150C, GLU158C, GLU179C, GLU248C, GLU318D, GLU322D, GLU333D, GLY106D, GLY125C, GLY126C, GLY138C, GLY334D, HIS115C, HIS315D, HIS327D, HIS330D, HIS336D, ILE309D, ILE325D, LEU112C, LEU113C, LEU117C, LEU130C, LEU139C, LEU151C, LEU316D, LEU317D, LYS124C, LYS329D, LYS339D, MET321D, PHE110C, PHE157C, PHE328D, PHE335D, PRO116C, PRO120C, PRO152C, PRO301D, PRO305D, PRO307D, PRO311D, PRO312D, PRO313D, SER320D, THR111C, THR121C, THR134C, THR155C, THR310D, THR319D, THR332D, TRP247C, TYR137C, TYR140C, TYR143C, TYR154C, TYR326D, VAL108C, VAL108D, VAL135C, VAL153C, VAL232C, VAL324D
• C-E: ALA127C, ALA168E, ALA172E, ALA173E, ALA244C, ARG101C, ARG133C, ARG160E, ARG163E, ARG171E, ARG186C, ARG189E, ARG193E, ARG245C, ARG270C, ARG276C, ARG278C, ARG9C, ASN246C, ASP132C, ASP228C, ASP268C, ASP29C, CYS128C, CYS230C, GLN104C, GLN131C, GLU129C, GLU136C, GLU141C, GLU161E, GLU169E, GLU248C, GLU250C, GLU251C, GLU273C, GLU281C, GLU36C, GLU630C, GLY125C, GLY126C, GLY138C, GLY162E, GLY180E, GLY186E, GLY187E, GLY191E, GLY272C, GLY27C, HIS428C, ILE165E, ILE166E, ILE229C, ILE288C, ILE629C, LEU130C, LEU139C, LEU174E, LEU181E, LEU195E, LEU32C, LEU96C, LYS124C, LYS185E, LYS190E, LYS37C, MET20C, MET249C, MET47C, PHE159E, PHE170E, PHE183E, PHE24C, PHE33C, PHE432C, PRO179E, PRO231C, PRO253C, PRO31C, PRO628C, SER188E, SER194E, SER271C, SER35C, THR134C, THR182E, THR252C, THR269C, TRP196E, TRP247C, TYR137C, TYR143C, TYR164E, TYR184E, TYR192E, TYR28C, VAL135C, VAL23C, VAL30C
• C-G: ALA107G, ALA244C, ALA60G, ALA61G, ALA62G, ALA73G, ALA83G, ARG180C, ARG241C, ARG243C, ARG245C, ARG270C, ARG86G, ASN246C, ASN75G, ASP118C, ASP123C, ASP177C, CYS108G, CYS119C, CYS122C, CYS56G, CYS59G, GLN131C, GLU248C, GLU273C, GLU71G, GLU74G, GLU85G, GLY125C, GLY272C, GLY55G, GLY84G, HIS167C, ILE175C, ILE54G, ILE68G, LEU236C, LEU238C, LEU275C, LEU58G, LYS124C, LYS166C, LYS89G, PHE242C, PRO109G, PRO120C, PRO169C, PRO72G, PRO77G, SER271C, SER57G, SER82G, THR110G, THR121C, THR269C, TRP247C, TYR66G, TYR69G, TYR87G, VAL70G
• C-H: ALA127H, ALA129H, ALA35H, ALA57H, ALA70H, ALA77H, ALA89H, ARG161C, ARG162C, ARG178C, ARG205C, ARG30H, ARG81H, ARG85H, ARG88H, ASP118C, ASP165C, ASP177C, ASP215C, ASP36H, ASP39H, ASP61H, ASP71H, CYS119C, GLU158C, GLU179C, GLU204C, GLU32H, GLU34H, GLU65H, GLY212C, GLY217C, GLY62H, GLY64H, GLY83H, HIS115C, HIS163C, HIS167C, HIS168C, HIS208C, HIS76H, HIS90H, HIS92H, HIS94H, ILE203C, ILE211C, ILE41H, ILE82H, ILE91H, LEU117C, LEU126H, LEU170C, LEU176C, LEU63H, LEU68H, LEU69H, LEU79H, LEU86H, LEU93H, LYS166C, LYS33H, LYS78H, LYS80H, MET214C, MET55H, PHE128H, PHE157C, PHE159C, PHE210C, PHE216C, PHE37H, PHE40H, PRO116C, PRO120C, PRO169C, PRO38H, PRO66H, PRO74H, PRO87H, SER58H, SER60H, SER73H, THR121C, THR160C, THR209C, THR213C, THR56H, TYR42H, VAL164C, VAL207C, VAL72H
• D-E: ALA100D, ALA107D, ALA111E, ALA168E, ALA172E, ALA173E, ALA229D, ALA251D, ALA372D, ALA50E, ALA69E, ARG116E, ARG133E, ARG147E, ARG171E, ARG189E, ARG193E, ARG240D, ARG269D, ARG367D, ARG371D, ARG409D, ARG42D, ARG64E, ARG67E, ARG73D, ARG87E, ARG91E, ASN112E, ASN20E, ASN245D, ASN24E, ASN306D, ASN377D, ASN47E, ASP106E, ASP120E, ASP131E, ASP149E, ASP178E, ASP231D, ASP247D, ASP304D, ASP360D, ASP406D, ASP408D, ASP51E, ASP56E, ASP62E, ASP84E, GLN308D, GLN379D, GLN77D, GLU102D, GLU115E, GLU117E, GLU139E, GLU154E, GLU18E, GLU227D, GLU333D, GLU341D, GLU352D, GLU67D, GLU71D, GLU73E, GLY106D, GLY109E, GLY153E, GLY176E, GLY180E, GLY187E, GLY191E, GLY21E, GLY233D, GLY23E, GLY243D, GLY334D, GLY340D, GLY354D, GLY361D, GLY362D, GLY54E, GLY60D, GLY65D, GLY79E, GLY85E, HIS129E, HIS144E, HIS336D, HIS58D, HIS63D, HIS72D, ILE135E, ILE230D, ILE309D, ILE357D, ILE52E, ILE59D, LEU104D, LEU105D, LEU107E, LEU114E, LEU121E, LEU136E, LEU141E, LEU146E, LEU152E, LEU174E, LEU181E, LEU195E, LEU22E, LEU232D, LEU234D, LEU239D, LEU25E, LEU266D, LEU353D, LEU378D, LEU381D, LEU41D, LEU49E, LEU55E, LEU58E, LEU62D, LEU74E, LEU77E, LEU99D, LYS103D, LYS134E, LYS148E, LYS177E, LYS185E, LYS190E, LYS250D, LYS329D, LYS339D, LYS369D, LYS42E, LYS68D, LYS81E, MET1E, MET364D, MET404D, MET44D, MET70D, PHE113E, PHE122E, PHE170E, PHE328D, PHE335D, PHE375D, PHE46E, PHE48E, PHE66D, PHE88E, PHE89E, PRO138E, PRO145E, PRO151E, PRO167E, PRO225D, PRO226D, PRO307D, PRO337D, PRO338D, PRO345D, PRO365D, PRO373D, PRO382D, PRO57D, PRO61E, PRO78E, SER110E, SER188E, SER194E, SER242D, SER359D, SER363D, SER374D, SER380D, SER76E, SER86E, THR105E, THR137E, THR157E, THR175E, THR182E, THR235D, THR310D, THR332D, THR346D, THR59E, THR64D, THR69D, THR74D, TRP108E, TRP196E, TRP26E, TRP80E, TYR150E, TYR192E, TYR246D, TYR252D, TYR326D, TYR331D, TYR343D, TYR355D, TYR356D, TYR366D, TYR57E, TYR60E, TYR61D, TYR72E, TYR75D, TYR81D, TYR93E, VAL101D, VAL108D, VAL118E, VAL228D, VAL244D, VAL248D, VAL342D, VAL344D, VAL358D, VAL368D, VAL370D, VAL376D, VAL407D, VAL53E, VAL55D, VAL56D, VAL70E, VAL71E, VAL75E
• D-F: ALA110F, ALA122F, ALA44F, ALA47F, ALA52F, ALA56F, ALA81F, ALA89F, ARG143F, ARG153D, ARG167D, ARG350D, ARG409D, ARG42D, ARG73D, ARG83F, ARG84D, ARG94F, ASN119F, ASN120F, ASN171D, ASN29D, ASN78D, ASP158D, ASP406D, ASP408D, ASP55F, ASP86D, CYS111F, CYS140F, CYS45F, CYS46F, GLN125F, GLN166D, GLN77D, GLU145F, GLU154D, GLU161D, GLU49F, GLU67D, GLY115F, GLY116F, GLY139F, GLY165D, GLY39D, GLY405D, GLY42F, GLY60D, GLY65D, GLY82F, HIS169D, HIS58D, HIS63D, HIS72D, ILE123F, ILE48F, ILE59D, ILE79D, LEU138D, LEU157D, LEU41D, LEU43F, LEU62D, LEU84F, LEU88D, LYS68D, LYS86F, LYS87F, MET117F, MET404D, MET50F, MET51F, MET70D, MET85D, MET88F, MET92F, PHE118F, PHE146D, PHE147D, PHE150D, PHE168D, PHE41F, PHE66D, PRO141F, PRO142F, PRO144F, PRO57D, PRO83D, PRO90F, SER128D, SER53F, SER85F, SER90D, THR135D, THR54F, THR64D, THR69D, THR80D, THR82D, TYR121F, TYR61D, TYR81D, TYR87D, VAL124F, VAL131D, VAL403D, VAL40D, VAL91F
• D-G: ALA107G, ALA112G, ALA32G, ALA60G, ALA61G, ALA62G, ALA65G, ARG167D, ARG167G, ARG174D, ARG303D, ARG314D, ARG36G, ARG73D, ARG84D, ARG86G, ARG97G, ASN171D, ASN78D, ASP158D, ASP181D, CYS101G, CYS104G, CYS108G, CYS56G, CYS59G, CYS63G, CYS98G, GLN166D, GLN77D, GLU105G, GLU106G, GLU154D, GLU161D, GLU169G, GLU180D, GLU184D, GLU185D, GLU189D, GLU318D, GLU333D, GLY102G, GLY111G, GLY165D, GLY39G, HIS169D, HIS170D, HIS327D, HIS330D, HIS38G, HIS72D, ILE113G, ILE325D, ILE79D, ILE99G, LEU103G, LEU115G, LEU157D, LEU159D, LEU182D, LEU317D, LEU33G, LEU58G, LEU76D, LYS179D, LYS329D, LYS34G, MET364D, PHE100G, PHE160D, PHE186D, PHE328D, PHE37G, PRO109G, PRO164G, PRO183D, PRO311D, PRO35G, PRO64G, SER57G, THR110G, THR155D, THR164D, THR332D, THR69D, THR74D, THR80D, TRP162D, TYR117G, TYR165G, TYR172D, TYR331D, TYR66G, TYR75D, TYR81D, VAL114G, VAL163D, VAL31G, VAL324D
• D-H: ALA77H, ARG314D, ARG43H, ARG46H, ARG75H, ASP39H, GLU318D, GLU45H, HIS315D, HIS327D, HIS76H, ILE41H, LEU316D, LEU317D, MET321D, MET44H, PHE328D, PHE37H, PHE40H, PRO312D, PRO313D, PRO38H, PRO47H, PRO74H, SER320D, THR319D, TYR42H, TYR48H, VAL324D
• E-F: ALA122F, ALA168E, ALA89F, ARG116E, ARG133E, ARG160E, ARG171E, ASN119F, ASN120F, ASN126F, ASP120E, ASP140E, GLN125F, GLU139E, GLU154E, GLU165F, GLY115F, GLY116F, GLY153E, HIS144E, ILE123F, ILE135E, ILE165E, ILE166E, LEU121E, LEU136E, LEU141E, LEU146E, LEU152E, LEU158E, LYS134E, LYS86F, LYS87F, MET117F, MET88F, PHE118F, PRO138E, PRO145E, PRO151E, PRO156E, PRO167E, PRO90F, SER114F, SER85F, THR137E, THR155E, THR157E, TYR121F, TYR150E, VAL124F
• E-G: ALA168E, ALA172E, ALA173E, ALA60G, ALA61G, ALA62G, ALA65G, ALA67G, ARG147G, ARG160E, ARG163E, ARG171E, ARG97G, ASN94G, ASP128G, ASP135G, CYS59G, CYS63G, GLU134G, GLU154E, GLU161E, GLU71G, GLU92G, GLY132G, GLY162E, ILE165E, ILE166E, ILE68G, ILE93G, LEU129G, LEU152E, LEU158E, LEU58G, LEU96G, LYS133G, LYS144G, LYS89G, MET136G, MET95G, PHE159E, PHE170E, PRO156E, PRO167E, PRO64G, SER127G, SER57G, THR155E, THR157E, TYR126G, TYR131G, TYR164E, TYR66G, TYR69G, TYR91G, VAL130G, VAL70G, VAL90G
• F-G: ALA110F, ALA112F, ALA122G, ALA146F, ALA150F, ALA162F, ALA29G, ALA32G, ALA56F, ALA65G, ALA67G, ARG143F, ARG147G, ARG148G, ARG152G, ARG159F, ARG166F, ARG169F, ARG40G, ARG83F, ARG97G, ASN119F, ASN120F, ASN126F, ASN164F, ASN94G, ASP123G, ASP128F, ASP128G, ASP134F, ASP135G, ASP28G, CYS101G, CYS111F, CYS140F, CYS63G, CYS98G, GLN125F, GLN146G, GLN153F, GLN155F, GLN161F, GLU120G, GLU125G, GLU145F, GLU149G, GLU165F, GLU168F, GLY109F, GLY115F, GLY116F, GLY139F, GLY160G, GLY167F, GLY39G, HIS38G, HIS41G, ILE106F, ILE123F, ILE148F, ILE99G, LEU103G, LEU129G, LEU147F, LEU154F, LEU170F, LEU33G, LEU96G, LYS144G, LYS151G, LYS156F, LYS157F, LYS158G, LYS34G, MET108F, MET117F, MET121G, MET152F, MET95G, PHE100G, PHE118F, PHE119G, PHE37G, PRO138F, PRO141F, PRO142F, PRO144F, PRO145G, PRO171F, PRO27G, PRO30G, PRO64G, SER107F, SER113F, SER114F, SER127G, THR143G, THR153G, TYR117G, TYR124G, TYR126G, TYR131G, TYR136F, TYR149F, TYR161G, TYR163F, TYR26G, TYR66G, VAL124F, VAL127F, VAL130G, VAL133F, VAL135F, VAL137F, VAL151F, VAL157G, VAL158F, VAL31G
• G-H: ALA107G, ALA112G, ALA35H, ALA83G, ARG167G, ARG30H, ARG43H, ARG45G, ARG46H, ARG86G, ASN48G, ASN75G, ASP36H, ASP39H, ASP49H, ASP76G, CYS108G, CYS53G, CYS56G, GLN25H, GLU105G, GLU106G, GLU169G, GLU171G, GLU32H, GLU34H, GLU45H, GLU51G, GLU78G, GLU85G, GLY111G, GLY49G, GLY84G, HIS46G, ILE41H, ILE54G, ILE54H, LEU170G, LEU50G, LEU50H, LEU58G, LYS33H, LYS52G, MET44H, PHE31H, PHE37H, PHE40H, PRO109G, PRO168G, PRO38H, PRO47G, PRO47H, PRO51H, PRO77G, PRO80G, SER82G, THR110G, THR44G, THR52H, THR53H, TYR42H, TYR48H, VAL114G