3I2B

the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase

• Total interactions analyzed: 66
• Total true interactions: 28
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 88
  • Norm. En. per Res.: -3.6838
• Hub Node: D(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-102.831	-14.8254	-206.515	-324.1714	88	18	6	8481	0	20	21
A-E	-86.8137	-12.4952	-165.816	-265.1249	84	9	6	7166	0	18	19
A-B	-12.9139	54.7846	-106.274	-64.4033	56	5	0	4279	0	11	17
A-C	0.0	-32.7424	-35.1751	-67.9175	29	1	0	1024	2	6	6
A-G	-6.9233	5.624	-296.015	-297.3143	81	6	0	8640	1	39	43
A-H	0.0	3.5588	-0.0011	3.5577	4	0	0	3	0	0	1
A-I	0.0	0.0	-0.0641	-0.0641	4	0	0	19	0	0	2
D-E	-81.3523	-14.7575	-171.853	-267.9628	85	11	6	7355	0	20	18
D-B	0.0	0.0	-18.9578	-18.9578	18	0	0	659	0	5	5
D-C	0.0	-2.1317	-1.2456	-3.3774	8	0	0	182	0	4	6
D-G	0.0	3.4994	-0.0046	3.4948	4	0	0	5	0	0	1
D-H	0.0	0.0	-0.0592	-0.0592	3	0	0	18	0	0	0
D-I	-10.1667	17.33	-296.609	-289.4457	82	7	0	8666	0	40	44
D-J	-3.4487	0.7017	-35.688	-38.4349	26	1	2	1589	0	5	5
D-L	-18.8096	5.1977	-28.8397	-42.4516	36	4	0	1225	8	13	12
E-G	0.0	0.0	-0.0763	-0.0763	4	0	0	34	0	0	1
E-H	-11.6496	5.4352	-287.882	-294.0964	81	7	0	8468	1	38	43
E-I	0.0	3.5113	-0.0047	3.5065	4	0	0	5	0	0	1
E-L	0.0	0.0	-23.0199	-23.0199	21	0	1	1037	0	6	5
B-C	-85.6918	-11.118	-184.014	-280.8238	88	15	6	8372	0	21	20
B-F	-87.4705	-15.8569	-180.81	-284.1373	84	12	5	7742	0	21	19
C-F	-92.4393	-15.2895	-171.614	-279.3429	83	13	6	7574	0	16	18
G-H	-84.0643	-15.7283	-165.823	-265.6155	82	14	7	7174	0	14	17
G-I	-89.1406	-13.9586	-185.862	-288.9611	87	12	7	7941	2	21	19
H-I	-86.0882	-15.7035	-175.731	-277.5228	83	13	7	7404	0	17	18
J-K	-100.0926	-11.9461	-191.031	-303.0697	85	12	6	7803	0	16	18
J-L	-91.0581	-15.9451	-183.564	-290.5673	82	12	6	7861	0	18	19
K-L	-83.1652	-13.9906	-189.234	-286.3898	86	14	6	7922	0	22	20

Interface residues

• A-D: ALA111D, ALA12A, ALA66A, ALA74A, ARG16A, ARG17A, ARG8A, ARG9A, ASN109D, ASN137D, ASN138D, ASN36D, ASN72A, ASP102D, ASP116D, ASP136D, ASP64A, ASP75A, CYS10A, CYS43D, GLN11A, GLN13A, GLU108D, GLU134D, GLU145D, GLU35D, GLU62A, GLY144D, GLY41D, GLY61A, GLY68A, HIS60A, ILE139D, ILE18A, ILE63A, LEU26D, LEU31D, LEU39D, LEU73A, LEU76A, LYS129A, LYS129D, LYS131A, LYS131D, LYS143A, LYS143D, LYS29D, LYS38D, LYS42D, LYS54A, LYS77A, MET69A, MET71A, MET80A, PHE30D, PHE40D, PRO65A, SER105D, SER15A, SER19A, SER28D, THR106D, THR107D, THR135D, THR58A, THR67A, TRP115D, TYR113D, TYR128A, TYR128D, TYR133A, TYR133D, TYR142D, TYR27D, TYR99D, VAL103D, VAL104D, VAL110D, VAL112D, VAL130D, VAL132D, VAL140D, VAL141D, VAL14A, VAL56A, VAL57A, VAL59A, VAL70A
• A-E: ALA111A, ALA12E, ALA66E, ALA74E, ARG16E, ARG17E, ARG9E, ASN109A, ASN137A, ASN138A, ASN36A, ASN72E, ASP116A, ASP136A, ASP64E, ASP75E, CYS10E, CYS43A, GLN11E, GLN13E, GLU108A, GLU134A, GLU145A, GLU35A, GLU62E, GLY144A, GLY41A, GLY61E, GLY68E, HIS60E, ILE139A, ILE18E, ILE63E, LEU26A, LEU31A, LEU39A, LEU73E, LEU76E, LYS129A, LYS129E, LYS131A, LYS131E, LYS143A, LYS143E, LYS29A, LYS38A, LYS54E, MET69E, MET71E, MET80E, PHE30A, PHE40A, PRO65E, SER105A, SER15E, SER19E, SER28A, THR106A, THR107A, THR135A, THR58E, THR67E, TRP115A, TYR113A, TYR128A, TYR128E, TYR133A, TYR133E, TYR142A, TYR27A, VAL103A, VAL104A, VAL110A, VAL112A, VAL130A, VAL132A, VAL140A, VAL141A, VAL14E, VAL55E, VAL56E, VAL57E, VAL59E, VAL70E
• A-B: ALA12A, ALA12B, ALA66A, ALA66B, ARG8A, ARG8A5, ARG8B, ARG9A, ARG9B, ASP64A, ASP64B, ASP75A, CB8.2229916.87640, CB9.06093-4.58342, CYS10A, CYS10B, GLN119A, GLN11A, GLN11B, GLN13A, GLN13B, GLU62A, GLU62B, GLY125A, GLY125B, GLY61A, GLY61B, GLY68A, GLY68B, HIS60A, HIS60B, ILE63A, ILE63B, LEU122A, LEU122B, LEU127A, LEU127B, MET71A, MET71B, PRO123A, PRO123B, PRO65A, PRO65B, THR67A, THR67B, TYR128A, TYR128B, TYR79A, TYR79B, VAL124A, VAL124B, VAL126A, VAL126B, VAL59A, VAL70A, VAL70B
• A-C: ARG8A, ARG8A5, ASN109C, ASP102C, ASP75A, CB8.91952-130.96954, GLN119A, GLN11A, GLU145C, GLU35C, GLY144C, LEU118A, LEU122A, LEU31C, LYS120A, LYS143C, LYS29C, PHE30C, PRO123A, SER28C, TYR142C, TYR79A, TYR99C, VAL103C, VAL104C, VAL112C, VAL121A, VAL124A, VAL126A
• A-G: ALA22A, ALA22G, ARG17A, ARG17G, ARG25A, ARG25G, ASN137A, ASN137G, ASN138A, ASN138G, ASN44A, ASN44G, ASN45A, ASN45G, ASN47A, ASN47G, ASN52A, ASN52G, ASN92A, ASN92G, ASP136A, ASP136G, ASP89A, ASP89G, ASP94A, ASP94G, ASP96A, ASP96G, CYS43A, CYS43G, GLU134A, GLU134G, GLY41A, GLY41G, GLY48A, GLY48G, GLY50A, GLY50G, HIS24A, HIS24G, HIS49A, HIS49G, HIS51A, HIS51G, HIS90A, HIS90G, LEU26A, LEU26G, LEU88A, LEU88G, LEU93A, LEU93G, LYS42A, LYS42G, LYS54A, LYS54G, LYS91A, LYS91G, MET85G, MET95A, MET95G, PHE20A, PHE20G, PHE40A, PHE40G, PRO46A, PRO46G, SER19A, SER19G, SER21A, SER21G, SER23A, SER23G, THR135A, THR135G, TYR133A, TYR133G, TYR53A, TYR53G, VAL97A, VAL97G
• A-H: ASN137A, ASN137H, ASP136A, ASP136H
• A-I: ARG17A, ARG17I, LYS54A, LYS54I
• D-E: ALA111E, ALA12D, ALA66D, ALA74D, ARG16D, ARG17D, ARG8D, ARG9D, ASN109E, ASN137E, ASN138E, ASN36E, ASN72D, ASP102E, ASP116E, ASP136E, ASP64D, ASP75D, CYS10D, CYS43E, GLN11D, GLN13D, GLU108E, GLU134E, GLU145E, GLU35E, GLU62D, GLY144E, GLY41E, GLY61D, GLY68D, HIS60D, ILE139E, ILE18D, ILE63D, LEU26E, LEU31E, LEU39E, LEU73D, LEU76D, LYS129D, LYS129E, LYS131D, LYS131E, LYS143D, LYS143E, LYS29E, LYS38E, LYS54D, MET69D, MET71D, MET80D, PHE30E, PHE40E, PRO65D, SER105E, SER15D, SER19D, SER28E, THR106E, THR107E, THR135E, THR58D, THR67D, TRP115E, TYR113E, TYR128D, TYR128E, TYR133D, TYR133E, TYR142E, TYR27E, VAL103E, VAL104E, VAL110E, VAL112E, VAL130E, VAL132E, VAL140E, VAL141E, VAL14D, VAL56D, VAL57D, VAL59D, VAL70D
• D-B: ARG9B, ASP102D, ASP75B, GLN119B, GLU145D, GLU35D, LEU118B, LEU122B, LEU31D, LYS120B, LYS29D, PHE30D, PRO123B, SER28D, TYR79B, VAL103D, VAL121B, VAL124B
• D-C: GLU34C, GLU34D, GLU35C, GLU35D, LEU39D, LYS38C, LYS38D, SER32C
• D-G: ASN137D, ASN137G, ASP136D, ASP136G
• D-H: ARG17D, ARG17H, LYS54H
• D-I: ALA22D, ALA22I, ARG17D, ARG17I, ARG25D, ARG25I, ASN137D, ASN137I, ASN138D, ASN138I, ASN44D, ASN44I, ASN45D, ASN45I, ASN47D, ASN47I, ASN52D, ASN52I, ASN92D, ASN92I, ASP136D, ASP136I, ASP89D, ASP89I, ASP94D, ASP94I, ASP96D, ASP96I, CYS43D, CYS43I, GLU134D, GLU134I, GLY41D, GLY41I, GLY48D, GLY48I, GLY50D, GLY50I, HIS24D, HIS24I, HIS49D, HIS49I, HIS51D, HIS51I, HIS90D, HIS90I, LEU26D, LEU26I, LEU88D, LEU88I, LEU93D, LEU93I, LYS42D, LYS42I, LYS54D, LYS54I, LYS91D, LYS91I, MET85D, MET85I, MET95D, MET95I, PHE20D, PHE20I, PHE40D, PHE40I, PRO46D, PRO46I, SER19D, SER19I, SER21D, SER21I, SER23D, SER23I, THR135D, THR135I, TYR133D, TYR133I, TYR53D, TYR53I, VAL97D, VAL97I
• D-J: ASN117D, ASN36J, ASP116D, GLN119D, GLU34J, GLU35J, GLY125D, GLY41J, HIS60D, LEU118D, LEU122D, LEU127D, LEU31J, LEU37J, LEU39J, LYS120D, LYS38J, PHE30J, PHE40J, PRO123D, SER28J, SER32J, TRP115D, VAL121D, VAL124D, VAL126D
• D-L: ALA66D, ALA66L, ARG8D, ARG8L, ARG9D, ARG9L, ASN72D, ASN72L, ASP64D, ASP64L, ASP75D, ASP75L, CYS10D, CYS10L, GLN11D, GLN11L, GLU62D, GLU62L, GLY125D, GLY125L, ILE63D, ILE63L, LEU122D, MET69D, MET69L, PRO123D, PRO123L, PRO65D, PRO65L, THR67D, THR67L, TYR79D, TYR79L, VAL124D, VAL124L, VAL126L
• E-G: ARG17E, ARG17G, LYS54E, LYS54G
• E-H: ALA22E, ALA22H, ARG17E, ARG17H, ARG25E, ARG25H, ASN137E, ASN137H, ASN138E, ASN138H, ASN44E, ASN44H, ASN45E, ASN45H, ASN47E, ASN47H, ASN52E, ASN52H, ASN92E, ASN92H, ASP136E, ASP136H, ASP89E, ASP89H, ASP94E, ASP94H, ASP96E, ASP96H, CYS43E, CYS43H, GLU134E, GLU134H, GLY41E, GLY41H, GLY48E, GLY48H, GLY50E, GLY50H, HIS24E, HIS24H, HIS49E, HIS49H, HIS51E, HIS51H, HIS90E, HIS90H, LEU26E, LEU26H, LEU88E, LEU88H, LEU93E, LEU93H, LYS42E, LYS42H, LYS54E, LYS54H, LYS91E, LYS91H, MET85E, MET95E, MET95H, PHE20E, PHE20H, PHE40E, PHE40H, PRO46E, PRO46H, SER19E, SER19H, SER21E, SER21H, SER23E, SER23H, THR135E, THR135H, TYR133E, TYR133H, TYR53E, TYR53H, VAL97E, VAL97H
• E-I: ASN137E, ASN137I, ASP136E, ASP136I
• E-L: ASN36E, GLN119L, GLU34E, GLU35E, GLY125L, GLY41E, HIS60L, LEU122L, LEU127L, LEU31E, LEU37E, LEU39E, LYS120L, LYS38E, PHE40E, PRO123L, SER28E, SER32E, TRP115L, VAL124L, VAL126L
• B-C: ALA111C, ALA12B, ALA66B, ALA74B, ARG16B, ARG17B, ARG8B, ARG9B, ASN109C, ASN137C, ASN138C, ASN36C, ASN72B, ASP102C, ASP116C, ASP136C, ASP64B, ASP75B, CYS10B, CYS43C, GLN11B, GLN13B, GLU108C, GLU134C, GLU145C, GLU35C, GLU62B, GLY144C, GLY41C, GLY61B, GLY68B, HIS60B, ILE139C, ILE18B, ILE63B, LEU26C, LEU31C, LEU39C, LEU73B, LEU76B, LYS129B, LYS129C, LYS131B, LYS131C, LYS143B, LYS143C, LYS29C, LYS38C, LYS42C, LYS54B, LYS77B, MET69B, MET71B, MET80B, PHE30C, PHE40C, PRO65B, SER105C, SER15B, SER19B, SER28C, THR106C, THR107C, THR135C, THR58B, THR67B, TRP115C, TYR113C, TYR128B, TYR133B, TYR133C, TYR142C, TYR27C, TYR99C, VAL103C, VAL104C, VAL110C, VAL112C, VAL130C, VAL132C, VAL140C, VAL141C, VAL14B, VAL55B, VAL56B, VAL57B, VAL59B, VAL70B
• B-F: ALA111B, ALA12F, ALA66F, ALA74F, ARG16F, ARG17F, ARG8F, ARG9F, ASN109B, ASN137B, ASN138B, ASN36B, ASN72F, ASP102B, ASP116B, ASP136B, ASP64F, ASP75F, CYS10F, CYS43B, GLN11F, GLN13F, GLU108B, GLU134B, GLU145B, GLU62F, GLY144B, GLY41B, GLY61F, GLY68F, HIS60F, ILE139B, ILE18F, ILE63F, LEU26B, LEU31B, LEU39B, LEU73F, LEU76F, LYS129B, LYS129F, LYS131B, LYS131F, LYS143B, LYS143F, LYS38B, LYS42B, LYS54F, LYS77F, MET69F, MET71F, MET80F, PHE30B, PHE40B, PRO65F, SER105B, SER15F, SER19F, SER28B, THR106B, THR107B, THR135B, THR58F, THR67F, TYR113B, TYR128F, TYR133B, TYR133F, TYR142B, TYR27B, VAL103B, VAL104B, VAL110B, VAL112B, VAL130B, VAL132B, VAL140B, VAL141B, VAL14F, VAL55F, VAL56F, VAL57F, VAL59F, VAL70F
• C-F: ALA111F, ALA12C, ALA66C, ALA74C, ARG16C, ARG17C, ARG9C, ASN109F, ASN137F, ASN138F, ASN36F, ASN72C, ASP116F, ASP136F, ASP64C, ASP75C, CYS10C, CYS43F, GLN11C, GLN13C, GLU108F, GLU134F, GLU145F, GLU62C, GLY144F, GLY41F, GLY61C, GLY68C, HIS60C, ILE139F, ILE18C, ILE63C, LEU26F, LEU31F, LEU39F, LEU73C, LEU76C, LYS129C, LYS129F, LYS131C, LYS131F, LYS143C, LYS143F, LYS29F, LYS38F, LYS54C, LYS77C, MET69C, MET71C, MET80C, PHE30F, PHE40F, PRO65C, SER105F, SER15C, SER19C, SER28F, THR106F, THR107F, THR135F, THR58C, THR67C, TYR113F, TYR128C, TYR133C, TYR133F, TYR142F, TYR27F, TYR99F, VAL103F, VAL104F, VAL110F, VAL112F, VAL130F, VAL132F, VAL140F, VAL141F, VAL14C, VAL55C, VAL56C, VAL57C, VAL59C, VAL70C
• G-H: ALA111H, ALA12G, ALA66G, ALA74G, ARG16G, ARG17G, ASN109H, ASN137H, ASN138H, ASN36H, ASN72G, ASP102H, ASP116H, ASP136H, ASP64G, CYS10G, CYS43H, GLN11G, GLN13G, GLU108H, GLU145H, GLU35H, GLU62G, GLY144H, GLY41H, GLY61G, GLY68G, HIS60G, ILE139H, ILE18G, ILE63G, LEU26H, LEU31H, LEU39H, LEU73G, LEU76G, LYS129G, LYS129H, LYS131G, LYS131H, LYS143G, LYS143H, LYS29H, LYS38H, LYS42H, LYS54G, LYS77G, MET69G, MET71G, MET80G, PHE30H, PHE40H, PRO65G, SER105H, SER15G, SER19G, SER28H, THR106H, THR107H, THR135H, THR58G, THR67G, TYR113H, TYR128G, TYR133G, TYR133H, TYR142H, TYR27H, TYR99H, VAL103H, VAL104H, VAL110H, VAL112H, VAL130H, VAL132H, VAL140H, VAL141H, VAL14G, VAL56G, VAL57G, VAL59G, VAL70G
• G-I: ALA111G, ALA12I, ALA66I, ALA74I, ARG16I, ARG17I, ARG8I, ARG9I, ASN109G, ASN137G, ASN138G, ASN36G, ASN72I, ASP102G, ASP116G, ASP136G, ASP64I, CYS10I, CYS43G, GLN119G, GLN11I, GLN13I, GLU108G, GLU134G, GLU145G, GLU35G, GLU62I, GLY144G, GLY41G, GLY61I, GLY68I, HIS60I, ILE139G, ILE18I, ILE63I, LEU26G, LEU31G, LEU39G, LEU73I, LEU76I, LYS129G, LYS129I, LYS131G, LYS131I, LYS143G, LYS143I, LYS29G, LYS38G, LYS42G, LYS54I, LYS77I, MET69I, MET71I, MET80I, PHE30G, PHE40G, PRO65I, SER105G, SER15I, SER19I, SER28G, THR106G, THR107G, THR135G, THR58I, THR67I, TRP115G, TYR113G, TYR128I, TYR133G, TYR133I, TYR142G, TYR27G, TYR99G, VAL103G, VAL104G, VAL110G, VAL112G, VAL130G, VAL132G, VAL140G, VAL141G, VAL14I, VAL56I, VAL57I, VAL59I, VAL70I
• H-I: ALA111I, ALA12H, ALA66H, ALA74H, ARG16H, ARG17H, ARG9H, ASN109I, ASN137I, ASN138I, ASN36I, ASN72H, ASP102I, ASP116I, ASP136I, ASP64H, ASP75H, CYS10H, CYS43I, GLN11H, GLN13H, GLU108I, GLU134I, GLU145I, GLU35I, GLU62H, GLY144I, GLY41I, GLY61H, GLY68H, HIS60H, ILE139I, ILE18H, ILE63H, LEU26I, LEU31I, LEU39I, LEU73H, LEU76H, LYS129H, LYS129I, LYS131H, LYS131I, LYS143H, LYS143I, LYS38I, LYS42I, LYS54H, MET69H, MET71H, MET80H, PHE30I, PHE40I, PRO65H, SER105I, SER15H, SER19H, SER28I, THR106I, THR107I, THR135I, THR58H, THR67H, TYR113I, TYR128H, TYR133H, TYR133I, TYR142I, TYR27I, TYR99I, VAL103I, VAL104I, VAL110I, VAL112I, VAL130I, VAL132I, VAL140I, VAL141I, VAL14H, VAL56H, VAL57H, VAL59H, VAL70H
• J-K: ALA111K, ALA12J, ALA66J, ALA74J, ARG16J, ARG17J, ARG9J, ASN109K, ASN137K, ASN138K, ASN36K, ASN72J, ASP102K, ASP116K, ASP136K, ASP64J, ASP75J, CYS10J, CYS43K, GLN11J, GLN13J, GLU108K, GLU134K, GLU145K, GLU35K, GLU62J, GLY144K, GLY41K, GLY61J, GLY68J, HIS60J, ILE139K, ILE18J, ILE63J, LEU26K, LEU31K, LEU39K, LEU73J, LEU76J, LYS129J, LYS129K, LYS131J, LYS131K, LYS143J, LYS143K, LYS29K, LYS38K, LYS42K, LYS54J, LYS77J, MET69J, MET71J, MET80J, PHE30K, PHE40K, PRO65J, SER105K, SER15J, SER19J, SER28K, THR106K, THR107K, THR135K, THR58J, THR67J, TYR113K, TYR128J, TYR133J, TYR133K, TYR142K, TYR27K, VAL103K, VAL104K, VAL110K, VAL112K, VAL130K, VAL132K, VAL140K, VAL141K, VAL14J, VAL55J, VAL56J, VAL57J, VAL59J, VAL70J
• J-L: ALA111J, ALA12L, ALA66L, ALA74L, ARG16L, ARG17L, ARG9L, ASN109J, ASN137J, ASN138J, ASN36J, ASN72L, ASP102J, ASP116J, ASP136J, ASP64L, ASP75L, CYS10L, CYS43J, GLN11L, GLN13L, GLU108J, GLU134J, GLU145J, GLU62L, GLY144J, GLY41J, GLY61L, GLY68L, HIS60L, ILE139J, ILE18L, ILE63L, LEU26J, LEU31J, LEU39J, LEU73L, LEU76L, LYS129J, LYS129L, LYS131J, LYS131L, LYS143J, LYS143L, LYS29J, LYS38J, LYS54L, MET69L, MET71L, MET80L, PHE30J, PHE40J, PRO65L, SER105J, SER15L, SER19L, SER28J, THR106J, THR107J, THR135J, THR58L, THR67L, TYR113J, TYR128L, TYR133J, TYR133L, TYR142J, TYR27J, TYR99J, VAL103J, VAL104J, VAL110J, VAL112J, VAL130J, VAL132J, VAL140J, VAL141J, VAL14L, VAL56L, VAL57L, VAL59L, VAL70L
• K-L: ALA111L, ALA12K, ALA66K, ALA74K, ARG16K, ARG17K, ARG8K, ARG9K, ASN109L, ASN137L, ASN138L, ASN36L, ASN72K, ASP102L, ASP116L, ASP136L, ASP64K, ASP75K, CYS10K, CYS43L, GLN11K, GLN13K, GLU108L, GLU134L, GLU145L, GLU35L, GLU62K, GLY144L, GLY41L, GLY61K, GLY68K, HIS60K, ILE139L, ILE18K, ILE63K, LEU26L, LEU31L, LEU39L, LEU73K, LEU76K, LYS129K, LYS129L, LYS131K, LYS131L, LYS143K, LYS143L, LYS29L, LYS38L, LYS42L, LYS54K, MET69K, MET71K, MET80K, PHE30L, PHE40L, PRO65K, SER105L, SER15K, SER19K, SER28L, THR106L, THR107L, THR135L, THR58K, THR67K, TYR113L, TYR128K, TYR133K, TYR133L, TYR142L, TYR27L, TYR99L, VAL103L, VAL104L, VAL110L, VAL112L, VAL130L, VAL132L, VAL140L, VAL141L, VAL14K, VAL55K, VAL56K, VAL57K, VAL59K, VAL70K