3HZN

structure of the salmonella typhimurium nfnb dihydropteridine reductase

• Total interactions analyzed: 28
• Total true interactions: 19
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 287
  • Norm. En. per Res.: -4.5243
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-170.2715	-88.1069	-993.132	-1251.5105	290	52	30	39978	2	60	52
A-D	0.0	29.1434	-29.8082	-0.6648	31	0	1	1361	0	13	20
A-G	0.0	5.1086	-78.9121	-73.8035	43	2	2	3392	0	27	21
A-H	-14.2879	3.1088	-126.804	-137.9831	56	4	1	4800	1	23	23
B-C	0.0	0.0	91.1849	91.1849	11	19	0	308	4	0	0
B-D	0.0	0.0	-0.8631	-0.8631	10	0	0	139	0	2	2
B-G	-8.5059	5.3491	-108.582	-111.7388	53	2	1	4391	2	24	23
C-D	-187.1061	-85.9206	-1002.63	-1275.6567	286	48	30	39855	3	58	51
C-E	0.0	-1.2535	-82.8038	-84.0573	49	1	2	3772	0	28	24
C-F	-19.0328	8.6809	-105.264	-115.616	55	5	1	4340	1	24	22
C-H	0.0	0.0	-0.135	-0.135	8	0	0	54	0	6	5
D-E	-15.8361	7.1353	-101.205	-109.9058	53	5	1	4415	1	24	23
D-G	0.0	0.0	-3.9506	-3.9506	8	0	0	165	0	3	3
D-H	-2.6855	-23.5767	-87.3994	-113.6616	53	0	0	3527	0	36	28
E-F	-178.1129	-76.6133	-981.68	-1236.4061	290	48	26	39462	2	59	51
E-G	0.0	-9.9908	-3.2999	-13.2907	12	0	0	209	1	7	7
E-H	-14.7412	-0.9438	-41.5945	-57.2795	19	4	0	1312	0	4	3
F-H	0.0	0.0	-0.4609	-0.4609	4	0	0	53	0	0	0
G-H	-228.2013	-86.9207	-983.343	-1298.465	287	58	28	39664	3	59	53

Interface residues

• A-B: ALA0A, ALA0B, ALA104A, ALA104B, ALA109A, ALA109B, ALA113A, ALA113B, ALA140A, ALA140B, ALA155A, ALA155B, ALA156A, ALA156B, ALA201A, ALA201B, ALA27A, ALA27B, ALA51A, ALA51B, ALA58A, ALA58B, ALA7A, ALA7B, ALA86A, ALA86B, ARG107A, ARG107B, ARG10A, ARG10B, ARG121A, ARG121B, ARG207A, ARG207B, ARG59A, ARG59B, ARG97A, ARG97B, ASN-1A, ASN-1B, ASN117A, ASN117B, ASN146A, ASN146B, ASN149A, ASN149B, ASN200A, ASN200B, ASN42A, ASN42B, ASN67A, ASN67B, ASN71A, ASN71B, ASP100A, ASP100B, ASP103A, ASP103B, ASP105A, ASP105B, ASP134A, ASP134B, ASP28A, ASP28B, ASP2A, ASP2B, CYS85A, CYS85B, GLN101A, GLN101B, GLN137A, GLN137B, GLN142A, GLN142B, GLN35A, GLN35B, GLN44A, GLN44B, GLN9A, GLN9B, GLU102A, GLU102B, GLU165A, GLU165B, GLU170B, GLU175A, GLU175B, GLU211A, GLU211B, GLU216A, GLU216B, GLU25A, GLU25B, GLU26A, GLU26B, GLU54A, GLU54B, GLU55A, GLU55B, GLU96A, GLU96B, GLY106A, GLY106B, GLY120A, GLY120B, GLY148A, GLY148B, GLY153A, GLY153B, GLY158A, GLY158B, GLY166A, GLY166B, GLY202A, GLY202B, GLY56A, GLY56B, HIS128A, HIS128B, HIS136A, HIS136B, HIS47A, HIS47B, HIS80A, HIS80B, ILE164A, ILE164B, ILE30A, ILE30B, ILE3A, ILE3B, ILE49A, ILE49B, LEU132A, LEU132B, LEU145A, LEU145B, LEU151A, LEU151B, LEU152A, LEU152B, LEU159A, LEU172A, LEU172B, LEU178A, LEU178B, LEU186A, LEU186B, LEU203A, LEU203B, LEU208A, LEU208B, LEU210A, LEU210B, LEU214A, LEU214B, LEU33A, LEU33B, LEU34A, LEU34B, LEU8A, LEU8B, LEU95A, LEU95B, LYS141A, LYS141B, LYS14A, LYS14B, LYS181A, LYS181B, LYS205A, LYS205B, LYS29A, LYS29B, LYS31A, LYS31B, LYS57A, LYS57B, LYS74B, LYS87A, LYS87B, PHE108A, PHE108B, PHE123A, PHE123B, PHE124A, PHE124B, PHE150A, PHE150B, PHE167A, PHE167B, PHE176A, PHE176B, PHE199A, PHE199B, PHE48A, PHE48B, PHE70A, PHE70B, PRO163A, PRO163B, PRO204A, PRO204B, PRO209A, PRO209B, PRO38A, PRO38B, PRO45A, PRO45B, SER12A, SER12B, SER131A, SER185A, SER185B, SER206A, SER206B, SER37A, SER37B, SER39A, SER39B, SER40A, SER40B, SER43A, SER43B, SER52A, SER52B, SER5A, SER5B, THR184A, THR212A, THR212B, THR213A, THR213B, THR215A, THR215B, THR32A, THR32B, THR41A, THR41B, THR53A, THR53B, THR69B, TRP138A, TRP138B, TRP46A, TRP46B, TRP94A, TRP94B, TYR11A, TYR11B, TYR144A, TYR144B, TYR183A, TYR183B, TYR36A, TYR36B, TYR68A, TYR68B, VAL143A, VAL143B, VAL147A, VAL147B, VAL154A, VAL154B, VAL162A, VAL162B, VAL187A, VAL187B, VAL189A, VAL189B, VAL217A, VAL217B, VAL4A, VAL4B, VAL50A, VAL50B, VAL60A, VAL60B, VAL6A, VAL6B, VAL81A, VAL81B, VAL82A, VAL82B, VAL83A, VAL83B, VAL98A, VAL98B, VAL99A, VAL99B
• A-D: ALA104A, ALA109A, ALA113A, ALA89D, ALA93D, ARG107A, ARG122D, ARG97D, ASP100A, ASP103A, ASP105A, ASP91D, ASP92D, GLN101A, GLU102A, GLU112A, GLU180D, GLU96D, GLY106A, GLY182D, HIS136D, LEU178D, LYS179D, LYS181D, LYS87D, PHE108A, PRO111A, THR110A, THR88D, TRP94D, TYR183D
• A-G: ALA113A, ALA113G, ALA115A, ALA115G, ALA116A, ALA116G, ALA125A, ALA125G, ARG107A, ARG107G, ARG121A, ARG121G, ARG122A, ARG122G, ARG129A, ARG129G, ASN117A, ASN117G, ASP118A, ASP118G, ASP126A, ASP126G, GLU112A, GLU112G, GLY120A, GLY120G, LEU132A, LEU132G, LEU95A, LEU95G, LYS119A, LYS119G, PHE108A, PHE123A, PHE123G, PHE124A, PHE124G, SER131A, SER131G, THR41A, THR41G, VAL130A, VAL130G
• A-H: ALA109A, ALA113A, ALA115A, ALA116A, ALA125A, ALA15H, ALA64H, ALA65H, ALA93A, ARG121A, ARG122A, ARG129A, ARG73H, ARG97A, ASN117A, ASN200H, ASN67H, ASN71H, ASP100A, ASP103A, ASP118A, ASP126A, ASP198H, ASP77H, ASP91A, ASP92A, GLU112A, GLU165H, GLU197H, GLU72H, GLU96A, GLY120A, GLY166H, GLY66H, ILE164H, LEU203H, LEU95A, LYS114A, LYS119A, LYS14H, LYS74H, PHE123A, PHE16H, PHE199H, PHE70H, PRO111A, SER12H, SER195H, THR110A, THR13H, THR69H, TYR68H, VAL130A, VAL162H, VAL196H, VAL99A
• B-C: ALA174C, ARG59C, ASP173C, GLU175C, GLY177C, HIS1B, LEU172C, LEU178C, LYS62C, PHE176C, VAL171C
• B-D: ALA93D, ARG97D, GLU180D, GLU96D, GLY177D, GLY202B, LEU203B, LYS181D, PHE199B, PRO204B
• B-G: ALA109G, ALA113G, ALA115G, ALA116G, ALA125G, ALA15B, ALA64B, ALA65B, ALA93G, ARG122G, ARG129G, ARG73B, ARG97G, ASN117G, ASN200B, ASN67B, ASN71B, ASP100G, ASP103G, ASP118G, ASP126G, ASP198B, ASP77B, ASP92G, GLU112G, GLU197B, GLU72B, GLU96G, GLY120G, GLY166B, GLY66B, ILE164B, LEU203B, LEU95G, LYS114G, LYS119G, LYS14B, LYS74B, PHE123G, PHE16B, PHE199B, PHE70B, PRO111G, SER12B, SER195B, THR110G, THR13B, THR69B, TYR68B, VAL130G, VAL162B, VAL196B, VAL99G
• C-D: ALA0C, ALA0D, ALA104C, ALA104D, ALA109C, ALA109D, ALA113C, ALA113D, ALA140C, ALA140D, ALA155C, ALA155D, ALA156C, ALA156D, ALA201C, ALA201D, ALA27C, ALA27D, ALA51C, ALA51D, ALA58C, ALA58D, ALA7C, ALA7D, ALA86C, ALA86D, ARG107C, ARG107D, ARG10C, ARG10D, ARG121C, ARG121D, ARG207C, ARG207D, ARG59C, ARG59D, ARG97C, ARG97D, ASN-1D, ASN117C, ASN117D, ASN146C, ASN146D, ASN149C, ASN149D, ASN200C, ASN200D, ASN42C, ASN42D, ASN67C, ASN67D, ASN71C, ASN71D, ASP100C, ASP100D, ASP103C, ASP103D, ASP105C, ASP105D, ASP134C, ASP134D, ASP28C, ASP28D, ASP2C, ASP2D, CYS85C, CYS85D, GLN101C, GLN101D, GLN137C, GLN137D, GLN142C, GLN142D, GLN35C, GLN35D, GLN44C, GLN44D, GLN9C, GLN9D, GLU102C, GLU102D, GLU165C, GLU165D, GLU175C, GLU175D, GLU211C, GLU211D, GLU216C, GLU216D, GLU25C, GLU25D, GLU26C, GLU26D, GLU54C, GLU54D, GLU55C, GLU55D, GLU96C, GLU96D, GLY106C, GLY106D, GLY148C, GLY148D, GLY153C, GLY153D, GLY158C, GLY158D, GLY166C, GLY166D, GLY202C, GLY202D, GLY56C, GLY56D, HIS128C, HIS128D, HIS136C, HIS136D, HIS47C, HIS47D, HIS80C, HIS80D, ILE164C, ILE164D, ILE30C, ILE30D, ILE3C, ILE3D, ILE49C, ILE49D, LEU132C, LEU132D, LEU145C, LEU145D, LEU151C, LEU151D, LEU152C, LEU152D, LEU159D, LEU172C, LEU172D, LEU178C, LEU178D, LEU186C, LEU186D, LEU203C, LEU203D, LEU208C, LEU208D, LEU210C, LEU210D, LEU214C, LEU214D, LEU33C, LEU33D, LEU34C, LEU34D, LEU8C, LEU8D, LEU95C, LEU95D, LYS141C, LYS141D, LYS14C, LYS14D, LYS181C, LYS181D, LYS205C, LYS205D, LYS29C, LYS29D, LYS31C, LYS31D, LYS57C, LYS57D, LYS74D, LYS87C, LYS87D, PHE108C, PHE108D, PHE123C, PHE123D, PHE124C, PHE124D, PHE150C, PHE150D, PHE167C, PHE167D, PHE176C, PHE176D, PHE199C, PHE199D, PHE48C, PHE48D, PHE70C, PHE70D, PRO163C, PRO163D, PRO204C, PRO204D, PRO209C, PRO209D, PRO38C, PRO38D, PRO45C, PRO45D, SER12C, SER12D, SER185C, SER185D, SER206C, SER206D, SER37C, SER37D, SER39C, SER39D, SER40C, SER40D, SER43C, SER43D, SER52C, SER52D, SER5C, SER5D, THR110D, THR184C, THR184D, THR212C, THR212D, THR213C, THR213D, THR215C, THR215D, THR32C, THR32D, THR41C, THR41D, THR53C, THR53D, TRP138C, TRP138D, TRP46C, TRP46D, TRP94C, TRP94D, TYR11C, TYR11D, TYR144C, TYR144D, TYR183C, TYR183D, TYR36C, TYR36D, TYR68C, TYR68D, VAL143C, VAL143D, VAL147C, VAL147D, VAL154C, VAL154D, VAL162C, VAL162D, VAL187C, VAL187D, VAL189C, VAL189D, VAL217C, VAL217D, VAL4C, VAL4D, VAL50C, VAL50D, VAL60C, VAL60D, VAL6C, VAL6D, VAL81C, VAL81D, VAL82C, VAL82D, VAL83C, VAL83D, VAL98C, VAL98D, VAL99C, VAL99D
• C-E: ALA109C, ALA109E, ALA113C, ALA113E, ALA115C, ALA115E, ALA116C, ALA116E, ALA125C, ALA125E, ARG107C, ARG107E, ARG121C, ARG121E, ARG122C, ARG122E, ARG129C, ARG129E, ASN117C, ASN117E, ASP118C, ASP118E, ASP126C, ASP126E, GLU102E, GLU112C, GLU112E, GLY120C, GLY120E, LEU132C, LEU132E, LEU95C, LEU95E, LYS114C, LYS114E, LYS119C, LYS119E, PHE108C, PHE108E, PHE123C, PHE123E, PHE124C, PHE124E, SER131C, SER131E, THR41C, THR41E, VAL130C, VAL130E
• C-F: ALA109C, ALA113C, ALA115C, ALA116C, ALA125C, ALA15F, ALA201F, ALA64F, ALA65F, ALA93C, ARG121C, ARG122C, ARG129C, ARG73F, ASN117C, ASN200F, ASN67F, ASN71F, ASP100C, ASP118C, ASP126C, ASP198F, ASP91C, ASP92C, GLU112C, GLU197F, GLU72F, GLU96C, GLY120C, GLY166F, GLY66F, HIS194F, ILE164F, LEU203F, LEU95C, LYS114C, LYS119C, LYS14F, LYS74F, PHE123C, PHE16F, PHE199F, PHE70F, PRO111C, SER12F, SER195F, THR110C, THR13F, THR69F, TYR11F, TYR68F, VAL130C, VAL162F, VAL196F, VAL99C
• C-H: ASP134C, GLN137C, HIS136C, LEU132C, LYS133C, LYS20H, SER19H, THR23H
• D-E: ALA109E, ALA113E, ALA115E, ALA116E, ALA125E, ALA15D, ALA201D, ALA64D, ALA65D, ALA93E, ARG122E, ARG129E, ARG73D, ARG97E, ASN117E, ASN200D, ASN67D, ASN71D, ASP100E, ASP118E, ASP126E, ASP198D, ASP91E, ASP92E, GLU112E, GLU197D, GLU72D, GLU96E, GLY120E, GLY166D, GLY66D, HIS194D, LEU203D, LEU95E, LYS114E, LYS119E, LYS14D, LYS74D, PHE123E, PHE16D, PHE199D, PHE70D, PRO111E, SER12D, SER195D, THR110E, THR13D, THR69D, TYR11D, TYR68D, VAL130E, VAL196D, VAL99E
• D-G: ALA109G, ALA113G, ARG107G, GLU180D, GLY177D, LYS181D, PHE108G, THR110G
• D-H: ALA140D, ALA15H, ALA169D, ALA174D, ALA201H, ALA86D, ALA89D, ARG129D, ARG73H, ASN200H, ASP134D, ASP135D, ASP173D, ASP17H, ASP198H, ASP77H, ASP91D, GLN137D, GLU170D, GLU180D, GLU197H, GLU54H, GLY177D, GLY182D, GLY202H, HIS128D, HIS136D, HIS194H, LEU132D, LEU178D, LEU186D, LEU203H, LEU76H, LYS133D, LYS179D, LYS181D, LYS20H, LYS21H, LYS57H, LYS87D, PHE16H, PHE199H, PRO18H, PRO204H, SER185D, SER195H, SER19H, THR184D, THR88D, TYR183D, VAL130D, VAL171D, VAL196H
• E-F: ALA0E, ALA0F, ALA104E, ALA104F, ALA109E, ALA109F, ALA113E, ALA113F, ALA140E, ALA140F, ALA155E, ALA155F, ALA156E, ALA156F, ALA201E, ALA201F, ALA27E, ALA27F, ALA51E, ALA51F, ALA58E, ALA58F, ALA7E, ALA7F, ALA86E, ALA86F, ARG107E, ARG107F, ARG10E, ARG10F, ARG121E, ARG121F, ARG207E, ARG207F, ARG59E, ARG59F, ARG97E, ARG97F, ASN-1E, ASN-1F, ASN117E, ASN117F, ASN146E, ASN146F, ASN149E, ASN149F, ASN200E, ASN200F, ASN42E, ASN42F, ASN67E, ASN67F, ASN71E, ASN71F, ASP100E, ASP100F, ASP103E, ASP103F, ASP105E, ASP105F, ASP134E, ASP134F, ASP28E, ASP28F, ASP2E, ASP2F, CYS85E, CYS85F, GLN101E, GLN101F, GLN137E, GLN137F, GLN142E, GLN142F, GLN35E, GLN35F, GLN44E, GLN44F, GLN9E, GLN9F, GLU102E, GLU102F, GLU165E, GLU165F, GLU170E, GLU175E, GLU175F, GLU211E, GLU211F, GLU216E, GLU216F, GLU25E, GLU25F, GLU26E, GLU26F, GLU54E, GLU54F, GLU55E, GLU55F, GLU96E, GLU96F, GLY106E, GLY106F, GLY148E, GLY148F, GLY153E, GLY153F, GLY158E, GLY158F, GLY166E, GLY166F, GLY202E, GLY202F, GLY56E, GLY56F, HIS128E, HIS128F, HIS136E, HIS136F, HIS193E, HIS47E, HIS47F, HIS80E, HIS80F, ILE164E, ILE164F, ILE30E, ILE30F, ILE3E, ILE3F, ILE49E, ILE49F, LEU132E, LEU132F, LEU145E, LEU145F, LEU151E, LEU151F, LEU152E, LEU152F, LEU159E, LEU159F, LEU172E, LEU172F, LEU178E, LEU178F, LEU186E, LEU186F, LEU203E, LEU203F, LEU208E, LEU208F, LEU210E, LEU210F, LEU214E, LEU214F, LEU33E, LEU33F, LEU34E, LEU34F, LEU8E, LEU8F, LEU95E, LYS133F, LYS141E, LYS141F, LYS14E, LYS14F, LYS181E, LYS181F, LYS205E, LYS205F, LYS29E, LYS29F, LYS31E, LYS31F, LYS57E, LYS57F, LYS74F, LYS87E, LYS87F, PHE108E, PHE108F, PHE123E, PHE123F, PHE124E, PHE124F, PHE150E, PHE150F, PHE167E, PHE167F, PHE176E, PHE176F, PHE199E, PHE199F, PHE48E, PHE48F, PHE70E, PHE70F, PRO163E, PRO163F, PRO204E, PRO204F, PRO209E, PRO209F, PRO38E, PRO38F, PRO45E, PRO45F, SER12E, SER12F, SER185E, SER206E, SER206F, SER37E, SER37F, SER39E, SER39F, SER40E, SER40F, SER43E, SER43F, SER52E, SER52F, SER5E, SER5F, THR110F, THR184E, THR184F, THR212E, THR212F, THR213E, THR213F, THR215E, THR215F, THR32E, THR32F, THR41E, THR41F, THR53E, THR53F, THR69F, TRP138E, TRP138F, TRP46E, TRP46F, TRP94E, TRP94F, TYR11E, TYR11F, TYR144E, TYR144F, TYR183E, TYR183F, TYR36E, TYR36F, TYR68E, TYR68F, VAL143E, VAL143F, VAL147E, VAL147F, VAL154E, VAL154F, VAL162E, VAL162F, VAL187E, VAL187F, VAL189E, VAL189F, VAL217E, VAL217F, VAL4E, VAL4F, VAL50E, VAL50F, VAL60E, VAL60F, VAL6E, VAL6F, VAL81E, VAL81F, VAL82E, VAL82F, VAL83E, VAL83F, VAL98E, VAL98F, VAL99E, VAL99F
• E-G: ALA0G, ALA24G, ASP134E, GLN137E, GLU170E, GLU25G, GLU26G, LEU132E, LYS133E, LYS179E, LYS29G, THR23G
• E-H: ALA0H, ALA89E, ARG129E, ASN-1H, ASP134E, ASP135E, ASP2H, GLN137E, HIS128E, HIS136E, LEU132E, LYS133E, SER-2H, SER131E, SER5H, THR88E, TRP138E, VAL130E, VAL6H
• F-H: ASN-1H, GLN137F, HIS136F, SER-2H
• G-H: ALA0G, ALA0H, ALA104G, ALA104H, ALA109G, ALA109H, ALA113G, ALA113H, ALA140G, ALA140H, ALA155G, ALA155H, ALA156G, ALA156H, ALA201G, ALA201H, ALA27G, ALA27H, ALA51G, ALA51H, ALA58G, ALA58H, ALA7G, ALA7H, ALA86G, ALA86H, ARG107G, ARG107H, ARG10G, ARG10H, ARG121G, ARG121H, ARG207G, ARG207H, ARG59G, ARG59H, ARG97G, ARG97H, ASN-1H, ASN117G, ASN146G, ASN146H, ASN149G, ASN149H, ASN200G, ASN200H, ASN42G, ASN42H, ASN67G, ASN67H, ASN71G, ASN71H, ASP100G, ASP100H, ASP103G, ASP103H, ASP105G, ASP105H, ASP134G, ASP134H, ASP135G, ASP28G, ASP28H, ASP2G, ASP2H, CYS85G, CYS85H, GLN101G, GLN101H, GLN137G, GLN137H, GLN142G, GLN142H, GLN35G, GLN35H, GLN44G, GLN44H, GLN9G, GLN9H, GLU102G, GLU102H, GLU165G, GLU165H, GLU175G, GLU175H, GLU211G, GLU211H, GLU216G, GLU216H, GLU25G, GLU25H, GLU26G, GLU26H, GLU54G, GLU54H, GLU55G, GLU55H, GLU96G, GLU96H, GLY106G, GLY106H, GLY120G, GLY148G, GLY148H, GLY153G, GLY153H, GLY158G, GLY158H, GLY166G, GLY166H, GLY202G, GLY202H, GLY56G, GLY56H, HIS128G, HIS128H, HIS136G, HIS136H, HIS47G, HIS47H, HIS80G, HIS80H, ILE164G, ILE164H, ILE30G, ILE30H, ILE3G, ILE3H, ILE49G, ILE49H, LEU132G, LEU132H, LEU145G, LEU145H, LEU151G, LEU151H, LEU152G, LEU152H, LEU159G, LEU172G, LEU178G, LEU178H, LEU186G, LEU186H, LEU203G, LEU203H, LEU208G, LEU208H, LEU210G, LEU210H, LEU214G, LEU214H, LEU33G, LEU33H, LEU34G, LEU34H, LEU8G, LEU8H, LEU95G, LEU95H, LYS141G, LYS141H, LYS14G, LYS14H, LYS181G, LYS181H, LYS205G, LYS205H, LYS29G, LYS29H, LYS31G, LYS31H, LYS57G, LYS57H, LYS74H, LYS87G, LYS87H, PHE108G, PHE108H, PHE123G, PHE123H, PHE124G, PHE124H, PHE150G, PHE150H, PHE167G, PHE167H, PHE176G, PHE176H, PHE199G, PHE199H, PHE48G, PHE48H, PHE70G, PHE70H, PRO163G, PRO163H, PRO204G, PRO204H, PRO209G, PRO209H, PRO38G, PRO38H, PRO45G, PRO45H, SER-2H, SER12G, SER12H, SER185G, SER185H, SER206G, SER206H, SER37G, SER37H, SER39G, SER39H, SER40G, SER40H, SER43G, SER43H, SER52G, SER52H, SER5G, SER5H, THR184G, THR184H, THR212G, THR212H, THR213G, THR213H, THR215G, THR215H, THR32G, THR32H, THR41G, THR41H, THR53G, THR53H, THR69H, TRP138G, TRP138H, TRP46G, TRP46H, TRP94G, TRP94H, TYR11G, TYR11H, TYR144G, TYR144H, TYR183G, TYR183H, TYR36G, TYR36H, TYR68G, TYR68H, VAL143G, VAL143H, VAL147G, VAL147H, VAL154G, VAL154H, VAL162G, VAL162H, VAL187G, VAL187H, VAL189G, VAL189H, VAL217G, VAL217H, VAL4G, VAL4H, VAL50G, VAL50H, VAL60G, VAL60H, VAL6G, VAL6H, VAL81G, VAL81H, VAL82G, VAL82H, VAL83G, VAL83H, VAL98G, VAL98H, VAL99G, VAL99H