3HYM

insights into anaphase promoting complex tpr subdomain assembly from a cdc26-apc6 structure

• Total interactions analyzed: 66
• Total true interactions: 14
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 149
  • Norm. En. per Res.: -4.3884
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-52.2688	-178.3324	-423.272	-653.8732	149	39	10	17143	13	58	36
A-F	0.0	0.0	-0.0012	-0.0012	2	0	0	3	0	0	1
B-D	-6.4103	9.577	-154.041	-150.8743	76	11	3	7735	0	16	18
B-F	-3.3143	-10.2988	-291.19	-304.803	122	19	8	11307	2	38	41
C-D	-45.5272	-173.5661	-385.228	-604.3213	149	51	8	16440	12	59	33
D-L	0.0	26.467	-259.532	-233.065	120	28	7	10363	0	38	41
E-F	-60.8809	-187.1982	-377.001	-625.0801	150	41	11	16472	13	63	34
F-H	-13.5437	7.8766	-156.835	-162.5021	73	11	2	7432	0	12	18
G-H	-69.0338	-182.6529	-377.367	-629.0537	144	39	10	16351	10	62	32
G-J	0.0	0.0	-0.0184	-0.0184	2	0	0	12	0	0	1
H-J	-4.2789	9.3363	-250.247	-245.1895	120	18	6	9894	0	36	38
I-J	-50.0144	-168.0426	-403.228	-621.285	145	40	8	16782	10	63	36
J-L	-16.9823	9.1837	-175.73	-183.5286	72	18	3	7958	0	14	18
K-L	-40.5562	-133.432	-381.101	-555.0892	141	38	9	16291	9	61	34

Interface residues

• A-B: ALA304B, ALA336B, ALA339B, ALA345B, ALA353B, ALA398B, ALA421B, ALA428B, ALA471B, ALA479B, ALA484B, ARG23A, ARG240B, ARG3A, ARG456B, ARG4A, ARG8A, ASN21A, ASN244B, ASN279B, ASN449B, ASN450B, ASN478B, ASN494B, ASP14A, ASP15A, ASP246B, ASP401B, ASP442B, ASP512B, CYS245B, CYS307B, CYS367B, CYS455B, CYS522B, GLN414B, GLU10A, GLU17A, GLU18A, GLU20A, GLU239B, GLU277B, GLU347B, GLU377B, GLU407B, GLU445B, GLU524B, GLY273B, GLY306B, GLY341B, GLY375B, GLY409B, GLY452B, GLY486B, GLY493B, GLY520B, HIS241B, HIS342B, HIS350B, HIS368B, HIS406B, HIS453B, HIS468B, HIS489B, HIS521B, ILE16A, ILE22A, ILE272B, ILE338B, ILE374B, ILE475B, ILE485B, ILE488B, LEU11A, LEU13A, LEU284B, LEU2A, LEU310B, LEU323B, LEU369B, LEU372B, LEU376B, LEU380B, LEU447B, LEU448B, LEU451B, LEU458B, LEU472B, LEU474B, LEU491B, LEU519B, LEU9A, LYS12A, LYS443B, LYS457B, LYS459B, LYS5A, PHE19A, PHE247B, PHE303B, PHE344B, PHE391B, PHE403B, PHE413B, PHE425B, PHE495B, PHE502B, PHE514B, PRO269B, PRO335B, PRO370B, PRO402B, PRO446B, PRO6A, SER343B, SER348B, SER480B, SER483B, SER490B, SER515B, THR274B, THR481B, THR513B, THR517B, THR7A, TRP337B, TRP418B, TRP444B, TYR242B, TYR243B, TYR308B, TYR309B, TYR340B, TYR357B, TYR373B, TYR378B, TYR461B, TYR482B, TYR487B, VAL270B, VAL276B, VAL312B, VAL346B, VAL404B, VAL408B, VAL410B, VAL411B, VAL454B, VAL516B
• A-F: ARG510F, LYS5A
• B-D: ALA353B, ALA353D, ALA355B, ALA355D, ALA356B, ALA356D, ALA360B, ALA360D, ALA361B, ALA361D, ALA387D, ARG320B, ARG320D, ARG389B, ARG389D, ASN382B, ASN382D, ASN383B, ASN383D, ASP351B, ASP351D, GLN352B, GLN352D, GLN362B, GLN362D, GLN393B, GLN393D, GLU330B, GLU330D, GLU349B, GLU349D, GLY334B, GLY334D, HIS350B, HIS350D, ILE374B, ILE374D, LEU363B, LEU363D, LEU380D, LEU386B, LEU386D, LYS331B, LYS331D, LYS365B, LYS365D, LYS385B, LYS385D, PHE344B, PHE344D, PHE358B, PHE358D, PHE390B, PHE390D, SER384B, SER384D, THR327B, THR327D, THR328B, THR328D, THR332B, THR332D, THR359B, THR359D, THR381B, THR381D, TRP337B, TRP337D, TYR333B, TYR333D, TYR340B, TYR340D, TYR357B, TYR357D, TYR378B, TYR378D
• B-F: ALA281B, ALA281F, ALA479F, ALA498B, ALA498F, ALA505B, ALA505F, ARG509B, ARG509F, ARG510B, ARG510F, ASN279B, ASN279F, ASN282B, ASN282F, ASN316B, ASN316F, ASN478B, ASN478F, ASN497B, ASN497F, ASP293B, ASP293F, ASP500B, ASP500F, ASP511B, ASP511F, ASP512B, ASP512F, ASP529B, ASP529F, CYS522B, CYS522F, GLN477B, GLN477F, GLU283B, GLU283F, GLU347B, GLU496B, GLU496F, GLU524B, GLU524F, GLY313B, GLY313F, GLY507B, GLY507F, GLY520B, GLY520F, GLY528B, GLY528F, HIS289B, HIS289F, HIS314B, HIS314F, HIS318B, HIS318F, HIS503B, HIS503F, HIS521B, HIS521F, ILE475B, ILE475F, ILE523B, ILE523F, ILE527B, ILE527F, LEU284B, LEU284F, LEU287B, LEU287F, LEU291B, LEU291F, LEU294B, LEU294F, LEU310B, LEU506B, LEU506F, LEU508B, LEU508F, LEU519B, LEU519F, LYS280B, LYS280F, LYS290B, LYS290F, LYS315B, LYS315F, LYS443F, PHE285B, PHE285F, PHE495B, PHE495F, PHE502B, PHE502F, PRO476B, PRO476F, SER288B, SER288F, THR504B, THR504F, TYR286B, TYR286F, TYR308B, TYR308F, TYR309B, TYR309F, TYR482B, TYR482F, TYR501B, TYR501F, TYR526B, TYR526F, VAL292B, VAL292F, VAL305F, VAL312B, VAL312F, VAL346B, VAL499B, VAL499F, VAL516B, VAL516F
• C-D: ALA304D, ALA336D, ALA339D, ALA345D, ALA353D, ALA398D, ALA421D, ALA428D, ALA471D, ALA479D, ALA484D, ARG23C, ARG3C, ARG456D, ARG4C, ARG8C, ASN21C, ASN244D, ASN279D, ASN316D, ASN449D, ASN450D, ASN478D, ASP14C, ASP15C, ASP246D, ASP401D, ASP442D, ASP512D, CYS245D, CYS307D, CYS367D, CYS455D, CYS522D, GLN414D, GLU10C, GLU17C, GLU18C, GLU20C, GLU239D, GLU277D, GLU347D, GLU349D, GLU377D, GLU400D, GLU407D, GLU445D, GLU524D, GLY273D, GLY306D, GLY341D, GLY375D, GLY379D, GLY409D, GLY452D, GLY486D, GLY493D, HIS241D, HIS342D, HIS350D, HIS368D, HIS406D, HIS453D, HIS468D, HIS489D, HIS521D, ILE16C, ILE22C, ILE272D, ILE338D, ILE374D, ILE475D, ILE485D, ILE488D, LEU11C, LEU13C, LEU275D, LEU284D, LEU2C, LEU310D, LEU323D, LEU369D, LEU372D, LEU376D, LEU380D, LEU447D, LEU448D, LEU451D, LEU472D, LEU474D, LEU491D, LEU519D, LEU9C, LYS12C, LYS443D, LYS457D, LYS459D, LYS5C, PHE19C, PHE247D, PHE303D, PHE344D, PHE391D, PHE403D, PHE413D, PHE425D, PHE495D, PHE502D, PHE514D, PRO269D, PRO335D, PRO370D, PRO402D, PRO446D, PRO6C, SER343D, SER348D, SER480D, SER483D, SER490D, SER515D, THR274D, THR481D, THR513D, THR517D, THR7C, TRP337D, TRP418D, TRP444D, TYR242D, TYR243D, TYR309D, TYR340D, TYR357D, TYR373D, TYR378D, TYR461D, TYR482D, TYR487D, VAL270D, VAL276D, VAL312D, VAL346D, VAL404D, VAL410D, VAL411D, VAL441D, VAL454D, VAL516D
• D-L: ALA281D, ALA281L, ALA479L, ALA498D, ALA498L, ALA505D, ALA505L, ARG509D, ARG509L, ARG510D, ARG510L, ASN279D, ASN279L, ASN282D, ASN282L, ASN316D, ASN316L, ASN478D, ASN478L, ASN494D, ASN497D, ASN497L, ASP293D, ASP293L, ASP500D, ASP500L, ASP511D, ASP511L, ASP512D, ASP512L, ASP529D, CYS522D, CYS522L, GLN477D, GLN477L, GLU283D, GLU283L, GLU347D, GLU496D, GLU496L, GLU524D, GLU524L, GLY313D, GLY313L, GLY507D, GLY507L, GLY520D, GLY520L, GLY528D, HIS289D, HIS289L, HIS314D, HIS314L, HIS503D, HIS503L, HIS521D, HIS521L, ILE475D, ILE475L, ILE523D, ILE523L, ILE527D, ILE527L, LEU284D, LEU284L, LEU287D, LEU287L, LEU291D, LEU291L, LEU294D, LEU294L, LEU310D, LEU506D, LEU506L, LEU508D, LEU508L, LEU519D, LEU519L, LYS280D, LYS280L, LYS290D, LYS290L, LYS315D, LYS315L, LYS443D, PHE285D, PHE285L, PHE495D, PHE495L, PHE502D, PHE502L, PRO476D, PRO476L, SER288D, SER288L, THR504D, THR504L, THR517D, TYR286D, TYR286L, TYR308D, TYR308L, TYR309D, TYR309L, TYR482D, TYR482L, TYR501D, TYR501L, TYR526D, TYR526L, VAL292D, VAL292L, VAL305L, VAL312D, VAL312L, VAL346D, VAL499D, VAL499L, VAL516D, VAL516L
• E-F: ALA304F, ALA336F, ALA339F, ALA345F, ALA353F, ALA394F, ALA398F, ALA421F, ALA428F, ALA471F, ALA479F, ALA484F, ARG23E, ARG240F, ARG3E, ARG456F, ARG4E, ARG509F, ARG8E, ASN21E, ASN244F, ASN279F, ASN449F, ASN450F, ASN478F, ASN494F, ASP14E, ASP15E, ASP246F, ASP401F, ASP442F, ASP512F, CYS245F, CYS307F, CYS367F, CYS522F, GLN414F, GLU10E, GLU17E, GLU18E, GLU20E, GLU239F, GLU277F, GLU347F, GLU377F, GLU400F, GLU407F, GLU445F, GLU524F, GLY273F, GLY306F, GLY334F, GLY341F, GLY375F, GLY409F, GLY452F, GLY486F, GLY493F, GLY520F, HIS241F, HIS342F, HIS350F, HIS368F, HIS406F, HIS453F, HIS468F, HIS489F, HIS521F, ILE16E, ILE22E, ILE272F, ILE338F, ILE374F, ILE475F, ILE485F, ILE488F, LEU11E, LEU13E, LEU275F, LEU284F, LEU2E, LEU310F, LEU323F, LEU369F, LEU372F, LEU376F, LEU380F, LEU447F, LEU448F, LEU451F, LEU458F, LEU472F, LEU474F, LEU491F, LEU519F, LEU9E, LYS12E, LYS443F, LYS457F, LYS459F, LYS5E, PHE19E, PHE247F, PHE303F, PHE344F, PHE403F, PHE413F, PHE425F, PHE495F, PHE502F, PHE514F, PRO269F, PRO335F, PRO370F, PRO402F, PRO446F, PRO6E, SER343F, SER348F, SER480F, SER483F, SER490F, SER515F, THR274F, THR440F, THR481F, THR513F, THR517F, THR7E, TRP418F, TRP444F, TYR242F, TYR243F, TYR340F, TYR357F, TYR373F, TYR378F, TYR461F, TYR482F, TYR487F, VAL270F, VAL276F, VAL312F, VAL346F, VAL404F, VAL408F, VAL410F, VAL411F, VAL454F, VAL516F
• F-H: ALA353F, ALA353H, ALA355F, ALA355H, ALA356F, ALA356H, ALA360F, ALA360H, ALA361F, ALA361H, ALA387F, ARG389F, ARG389H, ASN382F, ASN382H, ASN383F, ASN383H, ASP351F, ASP351H, GLN352F, GLN352H, GLN362F, GLN362H, GLN393F, GLN393H, GLU330F, GLU330H, GLU349F, GLU349H, GLY334F, GLY334H, HIS350F, HIS350H, ILE374F, ILE374H, LEU363F, LEU363H, LEU386F, LEU386H, LYS331F, LYS331H, LYS365F, LYS365H, LYS385F, LYS385H, PHE344F, PHE344H, PHE358F, PHE358H, PHE390F, PHE390H, SER384F, SER384H, THR327F, THR327H, THR328F, THR328H, THR332F, THR332H, THR359F, THR359H, THR381F, THR381H, TRP337F, TRP337H, TYR333F, TYR333H, TYR340F, TYR340H, TYR357F, TYR357H, TYR378F, TYR378H
• G-H: ALA304H, ALA336H, ALA339H, ALA345H, ALA353H, ALA398H, ALA421H, ALA428H, ALA471H, ALA479H, ALA484H, ALA498H, ARG23G, ARG3G, ARG456H, ARG4G, ARG8G, ASN21G, ASN244H, ASN279H, ASN449H, ASN450H, ASN478H, ASN494H, ASP14G, ASP15G, ASP246H, ASP401H, ASP512H, CYS245H, CYS307H, CYS367H, CYS522H, GLN414H, GLU10G, GLU17G, GLU18G, GLU20G, GLU239H, GLU277H, GLU347H, GLU349H, GLU377H, GLU400H, GLU407H, GLU445H, GLU524H, GLY273H, GLY306H, GLY341H, GLY409H, GLY452H, GLY486H, GLY493H, GLY520H, HIS241H, HIS342H, HIS350H, HIS368H, HIS406H, HIS453H, HIS468H, HIS489H, HIS521H, ILE16G, ILE22G, ILE272H, ILE338H, ILE374H, ILE475H, ILE485H, ILE488H, LEU11G, LEU13G, LEU275H, LEU284H, LEU2G, LEU310H, LEU323H, LEU369H, LEU372H, LEU376H, LEU380H, LEU447H, LEU448H, LEU451H, LEU458H, LEU472H, LEU474H, LEU491H, LEU519H, LEU9G, LYS12G, LYS457H, LYS459H, LYS5G, PHE19G, PHE247H, PHE303H, PHE344H, PHE391H, PHE403H, PHE413H, PHE425H, PHE495H, PHE502H, PHE514H, PRO269H, PRO335H, PRO370H, PRO402H, PRO446H, PRO6G, SER343H, SER348H, SER480H, SER483H, SER490H, SER515H, THR274H, THR481H, THR513H, THR517H, THR7G, TRP418H, TRP444H, TYR242H, TYR243H, TYR309H, TYR340H, TYR357H, TYR373H, TYR461H, TYR482H, TYR487H, VAL270H, VAL276H, VAL312H, VAL346H, VAL404H, VAL410H, VAL411H, VAL454H, VAL516H
• G-J: ARG510J, LYS5G
• H-J: ALA281H, ALA281J, ALA498H, ALA498J, ALA505H, ALA505J, ARG509H, ARG509J, ARG510H, ARG510J, ASN279H, ASN279J, ASN282H, ASN282J, ASN316H, ASN316J, ASN478H, ASN478J, ASN494J, ASN497H, ASN497J, ASP293H, ASP293J, ASP500H, ASP500J, ASP511H, ASP511J, ASP512H, ASP512J, ASP529H, ASP529J, CYS522H, CYS522J, GLN477H, GLN477J, GLU283H, GLU283J, GLU347H, GLU496H, GLU496J, GLU524H, GLU524J, GLY313H, GLY313J, GLY507H, GLY507J, GLY520H, GLY520J, GLY528H, GLY528J, HIS289H, HIS289J, HIS314H, HIS314J, HIS318H, HIS318J, HIS503H, HIS503J, HIS521H, HIS521J, ILE475H, ILE475J, ILE523H, ILE523J, ILE527H, ILE527J, LEU284H, LEU284J, LEU287H, LEU287J, LEU291H, LEU291J, LEU294H, LEU294J, LEU310H, LEU506H, LEU506J, LEU508H, LEU508J, LEU519H, LEU519J, LYS280H, LYS280J, LYS290H, LYS290J, LYS315H, LYS315J, PHE285H, PHE285J, PHE495H, PHE495J, PHE502H, PHE502J, PRO476H, PRO476J, SER288H, SER288J, THR504H, THR504J, TYR286H, TYR286J, TYR308H, TYR308J, TYR309H, TYR309J, TYR482J, TYR501H, TYR501J, TYR526H, TYR526J, VAL292H, VAL292J, VAL305H, VAL312H, VAL312J, VAL346H, VAL499H, VAL499J, VAL516H, VAL516J
• I-J: ALA304J, ALA336J, ALA339J, ALA345J, ALA353J, ALA398J, ALA421J, ALA428J, ALA471J, ALA479J, ALA484J, ALA498J, ARG23I, ARG3I, ARG456J, ARG4I, ARG8I, ASN21I, ASN244J, ASN279J, ASN449J, ASN450J, ASN478J, ASP14I, ASP15I, ASP246J, ASP401J, ASP442J, ASP512J, CYS245J, CYS307J, CYS367J, CYS522J, GLN414J, GLU10I, GLU17I, GLU18I, GLU20I, GLU239J, GLU277J, GLU347J, GLU349J, GLU377J, GLU400J, GLU407J, GLU445J, GLU524J, GLY273J, GLY306J, GLY334J, GLY341J, GLY409J, GLY452J, GLY486J, GLY493J, HIS241J, HIS342J, HIS350J, HIS368J, HIS406J, HIS453J, HIS468J, HIS489J, HIS521J, ILE16I, ILE22I, ILE272J, ILE338J, ILE374J, ILE432J, ILE475J, ILE485J, ILE488J, LEU11I, LEU13I, LEU275J, LEU278J, LEU284J, LEU2I, LEU310J, LEU323J, LEU369J, LEU372J, LEU376J, LEU380J, LEU447J, LEU448J, LEU451J, LEU472J, LEU474J, LEU491J, LEU519J, LEU9I, LYS12I, LYS443J, LYS457J, LYS459J, LYS5I, PHE19I, PHE247J, PHE303J, PHE344J, PHE403J, PHE413J, PHE425J, PHE495J, PHE502J, PHE514J, PRO269J, PRO335J, PRO370J, PRO402J, PRO446J, PRO6I, SER343J, SER348J, SER480J, SER483J, SER490J, SER515J, THR274J, THR481J, THR513J, THR517J, THR7I, TRP418J, TRP444J, TYR242J, TYR243J, TYR308J, TYR340J, TYR357J, TYR373J, TYR461J, TYR482J, TYR487J, VAL270J, VAL276J, VAL312J, VAL346J, VAL404J, VAL410J, VAL411J, VAL454J, VAL516J
• J-L: ALA353J, ALA353L, ALA355J, ALA355L, ALA356J, ALA356L, ALA360J, ALA360L, ALA361J, ALA361L, ARG389J, ARG389L, ASN382J, ASN382L, ASN383J, ASN383L, ASP351J, ASP351L, GLN352J, GLN352L, GLN362J, GLN362L, GLN393J, GLN393L, GLU330J, GLU330L, GLU349J, GLU349L, GLY334J, GLY334L, HIS350J, HIS350L, ILE374J, ILE374L, LEU363J, LEU363L, LEU386J, LEU386L, LYS331J, LYS331L, LYS365J, LYS365L, LYS385J, LYS385L, PHE344J, PHE344L, PHE358J, PHE358L, PHE390J, PHE390L, SER384J, SER384L, THR327J, THR327L, THR328J, THR328L, THR332J, THR332L, THR359J, THR359L, THR381J, THR381L, TRP337J, TRP337L, TYR333J, TYR333L, TYR340J, TYR340L, TYR357J, TYR357L, TYR378J, TYR378L
• K-L: ALA336L, ALA339L, ALA345L, ALA353L, ALA398L, ALA421L, ALA471L, ALA479L, ALA484L, ALA498L, ARG23K, ARG3K, ARG456L, ARG4K, ARG8K, ASN21K, ASN244L, ASN279L, ASN449L, ASN450L, ASN478L, ASP14K, ASP15K, ASP246L, ASP401L, ASP442L, ASP512L, CYS245L, CYS307L, CYS367L, CYS522L, GLN414L, GLU10K, GLU17K, GLU18K, GLU20K, GLU277L, GLU347L, GLU349L, GLU377L, GLU400L, GLU407L, GLU445L, GLY273L, GLY341L, GLY409L, GLY452L, GLY486L, GLY493L, GLY520L, HIS241L, HIS342L, HIS350L, HIS368L, HIS406L, HIS453L, HIS468L, HIS489L, HIS521L, ILE16K, ILE22K, ILE272L, ILE338L, ILE374L, ILE475L, ILE485L, ILE488L, LEU11K, LEU13K, LEU275L, LEU284L, LEU2K, LEU310L, LEU323L, LEU369L, LEU372L, LEU376L, LEU380L, LEU447L, LEU448L, LEU451L, LEU472L, LEU474L, LEU491L, LEU519L, LEU9K, LYS12K, LYS443L, LYS457L, LYS459L, LYS5K, PHE19K, PHE247L, PHE303L, PHE344L, PHE391L, PHE403L, PHE413L, PHE425L, PHE495L, PHE502L, PHE514L, PRO269L, PRO335L, PRO370L, PRO402L, PRO446L, PRO6K, SER343L, SER348L, SER480L, SER483L, SER490L, SER515L, THR274L, THR481L, THR513L, THR517L, THR7K, TRP337L, TRP418L, TRP444L, TYR242L, TYR243L, TYR340L, TYR357L, TYR373L, TYR378L, TYR461L, TYR482L, TYR487L, VAL270L, VAL276L, VAL312L, VAL346L, VAL404L, VAL408L, VAL410L, VAL411L, VAL454L, VAL516L