3HX7

crystal structure of human ferritin phe167serfsx26 mutant. this file is a part 3/3 of the split entry and contains the copies 5 and 6 of the total six copies of the biological unit that are present in the crystallographic asymmetric unit. the entire structure contains six copies of the biological unit in the crystallographic asymmetric unit and is described in remark 400

• Total interactions analyzed: 1128
• Total true interactions: 120
• Strongest Interaction:
  • Chains: F-M
  • Int. Res.: 126
  • Norm. En. per Res.: -5.4155
• Hub Node: A(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-I	-18.7135	47.6525	-141.419	-112.4799	70	9	1	6237	1	31	35
A-J	-71.5205	-148.7709	-396.141	-616.4324	118	30	6	14916	18	61	44
A-Q	-22.1335	46.4984	-161.268	-136.9031	70	7	1	6484	1	30	36
A-S	-22.4343	2.9148	-66.6677	-86.1871	34	2	1	2668	1	29	17
A-X	-5.7937	9.5602			8
a-i	-13.3892	54.2253	-153.146	-112.3099	69	7	1	6320	1	28	35
a-j	-71.2514	-194.2183	-415.861	-681.3307	126	27	7	15595	18	64	45
a-q	-5.7725	48.1503	-116.928	-74.5503	68	3	1	5377	1	27	33
a-s	-18.3533	1.8374	-60.2728	-76.7886	33	2	0	2382	1	28	16
a-x	-13.8936	14.6478			9
B-J	-12.368	43.2287	-154.211	-123.3503	69	7	1	6469	1	31	35
B-K	-63.1363	-164.4565	-440.929	-668.5218	125	13	6	15480	18	58	44
B-T	-14.1308	7.2888	-73.6561	-80.4982	39	2	1	2885	2	30	16
B-V	-26.264	7.9431			13
B-X	-9.8621	44.169			11
b-j	-25.7653	45.1882	-163.446	-144.0231	71	9	1	6613	1	31	36
b-k	-47.9859	-154.8778	-447.181	-650.0447	124	24	6	15701	20	59	45
b-t	-8.1701	3.283	-68.0499	-72.937	33	2	0	2489	1	27	16
b-v	-13.3435	7.4645			10
b-x	-8.2005	48.0428			15
C-K	-19.1132	44.0546	-159.474	-134.5326	71	4	1	6524	1	30	36
C-L	-65.2082	-152.0516	-420.564	-637.8237	123	16	6	15075	21	58	43
C-U	-5.2202	14.3208			8
C-V	-26.4214	44.0029			10
C-W	-23.59	14.3276			9
c-k	-13.0518	47.4009	-161.764	-127.4149	70	5	1	6518	1	29	36
c-l	-58.7069	-149.9755	-425.859	-634.5414	120	24	6	15765	19	59	43
c-u	-16.3071	2.3858			11
c-v	-9.6916	44.5115			10
c-w	0.0	12.7246			6
D-I	-77.4268	-130.0872	-417.313	-624.8269	119	22	6	15012	15	62	43
D-L	-26.3251	38.4555	-157.999	-145.8686	70	6	1	6488	1	31	35
D-Q	-13.3388	0.394	-76.2391	-89.1839	40	5	0	2901	2	28	16
D-R	-12.7479	3.3215	-60.8501	-70.2765	39	4	1	2806	1	29	16
D-W	-22.5034	42.8431			13
d-i	-61.9598	-154.7837	-421.757	-638.5005	119	22	6	15127	18	57	44
d-l	-4.102	55.6253	-145.975	-94.4517	69	6	1	6236	1	31	36
d-q	-11.1696	14.3622	-62.1225	-58.93	25	4	0	2259	1	25	13
d-r	-15.79	13.637	-58.3655	-60.5185	27	3	0	2086	0	25	13
d-w	-22.8421	48.3639			10
E-M	-7.8698	48.0275	-161.309	-121.1513	72	6	1	6559	1	31	36
E-P	-58.8444	-191.7793	-417.084	-667.7077	124	20	6	15431	24	62	45
E-R	-9.3166	45.0124	-156.556	-120.8602	71	9	1	6438	1	29	35
E-U	-7.1055	2.2478			8
E-W	-14.2698	3.4624			10
e-m	-5.8152	56.0622	-158.675	-108.428	72	6	1	6492	1	31	35
e-p	-62.7856	-151.96	-412.312	-627.0576	123	20	5	14971	16	59	44
e-r	-21.7447	51.4168	-160.184	-130.512	77	9	1	6422	1	29	36
e-u	-15.5651	1.7519			10
e-w	-5.5228	15.4625			9
F-M	-71.9429	-187.229	-423.176	-682.3479	126	35	7	15595	21	60	43
F-N	-13.9526	39.4305	-143.498	-118.0202	69	9	1	6291	1	30	35
F-Q	-5.6919	10.3012	-65.9062	-61.297	37	2	1	2717	0	29	17
F-R	-10.6296	0.1381	-105.699	-116.1905	55	7	1	4607	2	37	21
F-S	-36.0968	34.4833	-160.857	-162.4705	69	8	1	6516	1	30	36
f-m	-53.3473	-127.2999	-423.092	-603.7392	121	10	5	14966	12	57	43
f-n	-18.2215	48.907	-151.238	-120.5525	72	8	1	6381	1	29	35
f-q	-17.7956	16.5058	-57.6079	-58.8976	27	9	0	2130	0	25	13
f-r	-14.9871	12.1808	-59.5392	-62.3455	31	3	0	2114	0	25	13
f-s	-10.6469	41.8702	-155.424	-124.2008	70	5	1	6170	1	28	35
G-N	-52.727	-137.8644	-397.66	-588.2514	120	23	6	14814	19	61	45
G-O	-22.0246	41.3231	-157.684	-138.3855	71	9	1	6574	1	31	36
G-S	0.0	6.5714	-63.0278	-56.4564	39	8	0	2610	2	30	16
G-T	-8.343	38.5569	-155.568	-125.3541	69	2	1	6431	1	30	35
G-X	-18.8071	1.1205			11
g-n	-73.9419	-164.1452	-430.955	-669.042	124	24	7	15404	18	57	44
g-o	-10.9847	45.7315	-165.441	-130.6942	69	8	1	6499	1	32	36
g-s	-7.5842	14.6072	-61.1579	-54.1349	28	2	0	2213	0	25	13
g-t	-16.3531	50.7942	-115.01	-80.5688	53	5	1	4530	0	11	14
g-x	-5.1316	7.2822			8
H-O	-80.1013	-166.7708	-410.359	-657.2311	125	23	7	14993	19	62	43
H-P	-20.8879	42.7568	-159.088	-137.2191	70	5	1	6436	1	30	36
H-T	-21.7347	14.5703	-60.6996	-67.8641	29	2	0	2320	0	25	14
H-U	-16.5775	47.7445			13
H-V	-29.3141	8.1959			13
h-o	-47.7105	-150.1958	-415.835	-613.7413	121	25	5	15211	21	60	46
h-p	-18.9517	47.2453	-170.211	-141.9174	70	1	1	6606	1	32	35
h-t	-8.8496	1.3427	-0.0167	-7.5237	11	0	0	9	0	2	0
h-u	-20.699	36.5574			14
h-v	0.0	7.7318			8
I-J	-8.1053	6.5637	-67.269	-68.8106	37	4	1	2690	1	29	16
I-L	-11.5225	5.8769	-64.6283	-70.2739	35	1	0	2547	1	29	17
I-Q	-25.0732	34.3684	-164.929	-155.6338	72	9	1	6634	1	28	35
i-j	-29.6592	13.3787	-49.0252	-65.3056	27	5	0	2005	0	25	13
i-l	-18.625	14.0767	-53.9644	-58.5127	25	2	0	2058	0	25	14
i-q	-11.4685	56.7392	-162.176	-116.9052	69	6	1	6535	1	31	36
J-K	-26.9197	-7.7023	-83.2582	-117.8802	52	10	1	4064	4	35	20
J-X	-3.365	44.4953			11
j-k	-16.574	16.0513	-62.5298	-63.0524	27	3	0	2268	1	25	14
j-x	-5.7467	42.8169			10
K-L	-11.336	8.9036	-70.4883	-72.9207	36	2	0	2721	0	29	17
K-V	-18.4897	47.2908			11
k-l	-16.6431	16.7089	-58.4972	-58.4314	27	3	0	2108	1	25	13
k-v	-36.6707	43.0341			12
L-W	-21.7081	44.2509			12
l-w	-6.1662	53.5973			9
M-N	-8.0129	7.5908	-59.3531	-59.7753	37	3	0	2670	1	28	16
M-P	-14.3412	8.6047	-70.684	-76.4205	34	1	0	2686	1	29	16
M-R	-13.7551	44.8511	-150.861	-119.7649	70	7	1	6339	1	29	36
m-n	-3.0228	13.2273	-57.9508	-47.7463	28	4	0	2150	0	25	13
m-p	-15.5539	7.1755	-67.1513	-75.5297	38	0	0	2674	1	29	16
m-r	-11.2059	56.0119	-158.507	-113.701	72	4	1	6310	1	30	35
N-O	-2.9257	12.7652	-64.3625	-54.523	37	5	0	2342	1	25	13
N-S	-15.0011	41.0306	-157.398	-131.3685	71	2	1	6403	1	29	36
n-o	-17.393	14.8044	-61.7839	-64.3725	27	3	0	2227	0	25	13
n-s	-19.0871	49.8102	-168.666	-137.9429	69	9	1	6671	1	30	36
O-P	-4.3118	15.4763	-65.1098	-53.9453	35	2	0	2369	0	25	13
O-T	-33.0827	44.4894	-172.065	-160.6583	69	6	1	6666	1	31	36
o-p	-15.3955	13.189	-58.4327	-60.6393	32	7	0	2265	1	25	13
o-t	-4.8867	43.3759	-7.6201	30.8691	18	0	0	263	0	0	0
P-U	-18.7295	45.9171			10
p-u	-9.9819	49.0104			13
Q-S	-65.8939	-163.3659	-422.514	-651.7738	124	19	5	15129	21	65	46
q-s	-72.0937	-143.2751	-442.74	-658.1088	123	36	7	15888	18	61	43
R-W	-45.5682	-146.9213			38
r-w	-78.2361	-158.1528			39
T-X	-68.2769	-162.7426			39
t-x	-82.5362	-155.1498			39
U-V	-39.2879	-148.6816			36
u-v	-73.2509	-169.5402			37

Interface residues

• A-I: ALA102I, ALA110I, ALA116I, ARG6A, ARG73A, ARG76A, ASN108I, ASN151I, ASN71A, ASN8A, ASP113I, ASP123A, ASP128A, ASP128I, ASP136I, ASP147I, CYS127A, CYS127I, GLN109I, GLN4A, GLN70A, GLN72A, GLN7A, GLU104I, GLU131A, GLU131I, GLU137I, GLU138I, GLY146I, GLY74A, GLY75A, HIS115A, HIS115I, HIS125A, HIS133A, HIS148I, HIS153I, ILE142I, ILE5A, LEU107I, LEU111I, LEU112I, LEU126A, LEU130I, LEU135I, LEU141I, LEU149I, LEU67A, LYS105I, LYS106I, LYS140I, LYS143I, LYS144I, LYS68A, LYS98I, MET101I, MET145I, MET69A, PHE129A, PHE134I, PRO124A, SER119A, SER119I, SER3A, THR122A, THR132A, THR132I, THR150I, TYR9A, VAL139I
• A-J: ALA44A, ALA44J, ALA56A, ALA56J, ALA77A, ALA77J, ARG40A, ARG40J, ARG53A, ARG53J, ARG60A, ARG60J, ARG65A, ARG65J, ARG6A, ARG6J, ARG73A, ARG73J, ARG76A, ARG76J, ASN18J, ASN22A, ASN22J, ASN71A, ASN71J, ASP39A, ASP39J, ASP41A, ASP41J, ASP42A, ASP42J, ASP81A, ASP81J, ASP88A, ASP88J, GLN26A, GLN26J, GLN4A, GLN4J, GLN70A, GLN70J, GLN72A, GLN72J, GLN80A, GLN80J, GLU54A, GLU57A, GLU57J, GLU61A, GLU61J, GLU64A, GLU64J, GLU87A, GLU87J, GLU89A, GLU89J, GLY35A, GLY35J, GLY74A, GLY74J, GLY75A, GLY75J, ILE5A, ILE5J, ILE82A, ILE82J, LEU25A, LEU25J, LEU32A, LEU32J, LEU34A, LEU34J, LEU66A, LEU66J, LEU67A, LEU67J, LEU78A, LEU78J, LYS68A, LYS68J, LYS83A, LYS83J, LYS84A, LYS84J, MET1A, MET69A, MET69J, PHE36A, PHE36J, PHE38A, PHE38J, PHE79A, PHE79J, PRO85A, PRO85J, SER28A, SER28J, SER2A, SER2J, SER33A, SER33J, SER3A, SER3J, SER49J, THR30A, THR30J, TRP90A, TRP90J, TYR29A, TYR29J, TYR37A, TYR37J, TYR63A, TYR63J, VAL21A, VAL21J, VAL43A, VAL43J
• A-Q: ALA110A, ALA116A, ARG6Q, ARG73Q, ARG76Q, ASN108A, ASN151A, ASN71Q, ASN8Q, ASP113A, ASP123Q, ASP128A, ASP128Q, ASP136A, ASP147A, CYS127A, CYS127Q, GLN109A, GLN4Q, GLN70Q, GLN72Q, GLN7Q, GLU104A, GLU131A, GLU131Q, GLU137A, GLU138A, GLY146A, GLY74Q, GLY75Q, HIS115A, HIS115Q, HIS125Q, HIS133Q, HIS148A, HIS153A, ILE142A, ILE5Q, LEU107A, LEU111A, LEU112A, LEU126Q, LEU130A, LEU135A, LEU141A, LEU149A, LEU67Q, LYS105A, LYS106A, LYS140A, LYS143A, LYS144A, LYS68Q, LYS98A, MET101A, MET145A, MET69Q, PHE129Q, PHE134A, PRO124Q, SER119A, SER119Q, SER2Q, SER3Q, THR122Q, THR132A, THR132Q, THR150A, TYR9Q, VAL139A
• A-S: ALA160A, ALA160S, ALA44S, ARG154A, ARG40S, ASN151A, ASP147A, ASP39S, ASP41S, ASP42S, GLU159A, GLU46S, GLY146A, GLY156S, GLY157A, GLY157S, HIS148A, ILE142A, LEU149A, LEU152A, LEU152S, LEU155S, LEU45S, LYS143A, LYS144A, LYS92S, MET101A, MET145A, PHE38S, PRO158A, PRO94S, THR150A, THR93S, VAL43S
• A-X: ASP147X, ASP39A, ASP41A, ASP42A, GLU159X, GLU46A, LYS143X, LYS92A
• a-i: ALA102i, ALA110i, ALA116i, ARG6a, ARG73a, ARG76a, ASN108i, ASN151i, ASN71a, ASN8a, ASP113i, ASP123a, ASP128a, ASP128i, ASP136i, ASP147i, CYS127a, CYS127i, GLN109i, GLN4a, GLN70a, GLN72a, GLN7a, GLU104i, GLU131a, GLU131i, GLU137i, GLU138i, GLY146i, GLY74a, GLY75a, HIS115a, HIS115i, HIS125a, HIS133a, HIS148i, HIS153i, ILE142i, ILE5a, LEU107i, LEU111i, LEU112i, LEU126a, LEU130i, LEU135i, LEU141i, LEU149i, LYS105i, LYS106i, LYS140i, LYS143i, LYS144i, LYS68a, LYS98i, MET101i, MET145i, MET69a, PHE129a, PHE134i, PRO124a, SER119a, SER119i, SER3a, THR122a, THR132a, THR132i, THR150i, TYR9a, VAL139i
• a-j: ALA44a, ALA44j, ALA56a, ALA56j, ALA77a, ALA77j, ARG0j, ARG40a, ARG40j, ARG53a, ARG53j, ARG60a, ARG60j, ARG65a, ARG65j, ARG6a, ARG6j, ARG73a, ARG73j, ARG76a, ARG76j, ASN18a, ASN18j, ASN22a, ASN22j, ASN71a, ASN71j, ASP39a, ASP39j, ASP41a, ASP41j, ASP42a, ASP42j, ASP81a, ASP81j, ASP88a, ASP88j, GLN26a, GLN26j, GLN4a, GLN4j, GLN70a, GLN70j, GLN72a, GLN72j, GLN80a, GLN80j, GLU46a, GLU46j, GLU57a, GLU57j, GLU61a, GLU61j, GLU64a, GLU64j, GLU87a, GLU87j, GLU89a, GLU89j, GLY35a, GLY35j, GLY74a, GLY74j, GLY75a, GLY75j, HIS50a, HIS50j, ILE5a, ILE5j, ILE82a, ILE82j, LEU25a, LEU25j, LEU32a, LEU32j, LEU34a, LEU34j, LEU45a, LEU66a, LEU66j, LEU67a, LEU67j, LEU78a, LEU78j, LYS68a, LYS68j, LYS83a, LYS83j, LYS84a, LYS84j, MET1j, MET69a, MET69j, PHE36a, PHE36j, PHE38a, PHE38j, PHE79a, PHE79j, PRO85a, PRO85j, SER28a, SER28j, SER2j, SER33a, SER33j, SER3a, SER3j, SER49a, SER49j, THR30a, THR30j, TRP90a, TRP90j, TYR29a, TYR29j, TYR31a, TYR31j, TYR37a, TYR37j, TYR63a, TYR63j, VAL21a, VAL21j, VAL43a, VAL43j
• a-q: ALA102a, ALA110a, ALA116a, ARG6q, ARG73q, ARG76q, ASN108a, ASN151a, ASN71q, ASN8q, ASP113a, ASP123q, ASP128a, ASP128q, ASP136a, ASP147a, CYS127a, CYS127q, GLN109a, GLN4q, GLN70q, GLN72q, GLN7q, GLU104a, GLU131a, GLU131q, GLU137a, GLU138a, GLY146a, GLY74q, HIS115a, HIS125q, HIS133a, HIS133q, HIS148a, HIS153a, ILE142a, ILE5q, LEU107a, LEU111a, LEU112a, LEU126q, LEU130a, LEU135a, LEU141a, LEU149a, LYS105a, LYS106a, LYS140a, LYS143a, LYS144a, LYS68q, LYS98a, MET101a, MET145a, MET69q, PHE129q, PHE134a, PRO124q, SER119a, SER119q, SER3q, THR122q, THR132a, THR132q, THR150a, TYR9q, VAL139a
• a-s: ALA160a, ALA44s, ARG154a, ARG40s, ASN151a, ASP147a, ASP39s, ASP41s, ASP42s, GLU159a, GLU46s, GLY146a, GLY156s, GLY157a, HIS148a, ILE142a, LEU149a, LEU152a, LEU152s, LEU155s, LEU45s, LYS143a, LYS144a, LYS92s, MET101a, MET145a, PHE36s, PHE38s, PRO158a, PRO94s, THR150a, THR93s, VAL43s
• a-x: ALA44a, ASN151x, ASP147x, ASP39a, ASP41a, ASP42a, GLU46a, LYS143x, THR150x
• B-J: ALA102J, ALA110J, ALA116J, ARG6B, ARG73B, ARG76B, ASN108J, ASN151J, ASN71B, ASN8B, ASP113J, ASP123B, ASP128B, ASP128J, ASP136J, ASP147J, CYS127B, CYS127J, GLN109J, GLN4B, GLN70B, GLN72B, GLN7B, GLU104J, GLU131B, GLU131J, GLU137J, GLU138J, GLY146J, GLY74B, HIS115B, HIS115J, HIS125B, HIS133B, HIS133J, HIS148J, HIS153J, ILE142J, ILE5B, LEU107J, LEU111J, LEU112J, LEU126B, LEU130J, LEU135J, LEU141J, LEU149J, LYS105J, LYS106J, LYS140J, LYS143J, LYS144J, LYS68B, LYS98J, MET101J, MET145J, MET69B, PHE129B, PHE134J, PRO124B, SER119B, SER119J, SER3B, THR122B, THR132B, THR132J, THR150J, TYR9B, VAL139J
• B-K: ALA44B, ALA44K, ALA56B, ALA56K, ALA77B, ALA77K, ARG40B, ARG40K, ARG53B, ARG53K, ARG60B, ARG60K, ARG65B, ARG65K, ARG6B, ARG6K, ARG73B, ARG73K, ARG76B, ARG76K, ASN18K, ASN22B, ASN22K, ASN71B, ASN71K, ASP39B, ASP39K, ASP41B, ASP41K, ASP42B, ASP42K, ASP81B, ASP81K, ASP88B, ASP88K, GLN26B, GLN26K, GLN4B, GLN4K, GLN70B, GLN70K, GLN72B, GLN72K, GLN80B, GLN80K, GLU46B, GLU46K, GLU57B, GLU57K, GLU61B, GLU61K, GLU64B, GLU64K, GLU87B, GLU87K, GLU89B, GLU89K, GLY35B, GLY35K, GLY74B, GLY74K, GLY75B, GLY75K, HIS50B, HIS50K, ILE5B, ILE5K, ILE82B, ILE82K, LEU25B, LEU25K, LEU32B, LEU32K, LEU34B, LEU34K, LEU66B, LEU66K, LEU67B, LEU67K, LEU78B, LEU78K, LYS68B, LYS68K, LYS83B, LYS83K, LYS84B, LYS84K, MET1B, MET1K, MET69B, MET69K, PHE36B, PHE36K, PHE38B, PHE38K, PHE79B, PHE79K, PRO85B, PRO85K, SER28B, SER28K, SER2B, SER2K, SER33B, SER33K, SER3B, SER3K, SER49B, SER49K, THR30B, THR30K, TRP90B, TRP90K, TYR29B, TYR29K, TYR31B, TYR31K, TYR37B, TYR37K, TYR63B, TYR63K, VAL21B, VAL21K, VAL43B, VAL43K
• B-T: ALA160B, ALA44T, ARG154B, ARG40T, ASN151B, ASP147B, ASP39T, ASP41T, ASP42T, GLU159B, GLU46T, GLY146B, GLY156T, GLY157B, GLY157T, GLY161B, GLY91T, HIS148B, ILE142B, LEU149B, LEU152B, LEU152T, LEU155T, LEU45T, LYS143B, LYS144B, LYS92T, MET101B, MET145B, PHE36T, PHE38T, PRO158B, PRO94T, SER49T, THR150B, THR93T, TYR37T, VAL43T, VAL48T
• B-V: ALA44B, ARG154V, ASN151V, ASP147V, ASP39B, ASP41B, ASP42B, GLU159V, GLU46B, LYS143V, LYS92B, THR150V, VAL43B
• B-X: ARG6X, ASP123X, ASP128B, ASP128X, ASP136B, GLN7X, GLU131B, GLU131X, HIS115B, HIS125X, LYS105B
• b-j: ALA102j, ALA110j, ALA116j, ARG6b, ARG73b, ARG76b, ASN108j, ASN151j, ASN71b, ASN8b, ASP113j, ASP123b, ASP128b, ASP128j, ASP136j, ASP147j, CYS127b, CYS127j, GLN109j, GLN4b, GLN70b, GLN72b, GLN7b, GLU104j, GLU131b, GLU131j, GLU137j, GLU138j, GLY146j, GLY74b, GLY75b, HIS115b, HIS115j, HIS125b, HIS133b, HIS148j, HIS153j, ILE142j, ILE5b, LEU107j, LEU111j, LEU112j, LEU126b, LEU130j, LEU135j, LEU141j, LEU149j, LEU67b, LYS105j, LYS106j, LYS140j, LYS143j, LYS144j, LYS68b, LYS98j, MET101j, MET145j, MET69b, PHE129b, PHE134j, PRO124b, SER119b, SER119j, SER2b, SER3b, THR122b, THR132b, THR132j, THR150j, TYR9b, VAL139j
• b-k: ALA44b, ALA44k, ALA56b, ALA56k, ALA77b, ALA77k, ARG40b, ARG40k, ARG53b, ARG53k, ARG60b, ARG60k, ARG65b, ARG65k, ARG6b, ARG6k, ARG73b, ARG73k, ARG76b, ARG76k, ASN18b, ASN18k, ASN22b, ASN22k, ASN71b, ASN71k, ASP39b, ASP39k, ASP41b, ASP41k, ASP42b, ASP42k, ASP81b, ASP81k, ASP88b, ASP88k, GLN26b, GLN26k, GLN4b, GLN4k, GLN70b, GLN70k, GLN72b, GLN72k, GLN80b, GLN80k, GLU46b, GLU46k, GLU57b, GLU57k, GLU61b, GLU61k, GLU64b, GLU64k, GLU87b, GLU87k, GLU89b, GLU89k, GLY35b, GLY35k, GLY74b, GLY74k, GLY75b, GLY75k, HIS50b, HIS50k, ILE5b, ILE5k, ILE82b, ILE82k, LEU25b, LEU25k, LEU32b, LEU32k, LEU34b, LEU34k, LEU66b, LEU66k, LEU67b, LEU67k, LEU78b, LEU78k, LYS68b, LYS68k, LYS83b, LYS83k, LYS84b, LYS84k, MET69b, MET69k, PHE36b, PHE36k, PHE38b, PHE38k, PHE79b, PHE79k, PRO85b, PRO85k, SER28b, SER28k, SER2b, SER2k, SER33b, SER33k, SER3b, SER3k, SER49b, SER49k, THR30b, THR30k, TRP90b, TRP90k, TYR29b, TYR29k, TYR31b, TYR31k, TYR37b, TYR37k, TYR63b, TYR63k, VAL21b, VAL21k, VAL43b, VAL43k
• b-t: ALA44t, ARG154b, ARG40t, ASN151b, ASP147b, ASP39t, ASP41t, ASP42t, GLU159b, GLU46t, GLY146b, GLY91t, HIS148b, ILE142b, LEU149b, LEU152b, LEU155b, LEU45t, LYS143b, LYS144b, LYS92t, MET101b, MET145b, PHE36t, PHE38t, PRO158b, PRO94t, SER49t, THR150b, THR93t, TYR37t, VAL43t, VAL48t
• b-v: ARG154v, ASP147v, ASP39b, ASP41b, ASP42b, GLU159v, GLU46b, LYS143v, LYS92b, VAL43b
• b-x: ASN108b, ASP123x, ASP128b, ASP128x, ASP136b, GLN4x, GLN7x, GLU131b, GLU131x, GLY146b, HIS115b, HIS125x, LYS105b, LYS143b, LYS68x
• C-K: ALA102K, ALA110K, ALA116K, ARG6C, ARG73C, ARG76C, ASN108K, ASN151K, ASN71C, ASN8C, ASP113K, ASP123C, ASP128C, ASP128K, ASP136K, ASP147K, CYS127C, CYS127K, GLN109K, GLN4C, GLN70C, GLN72C, GLN7C, GLU104K, GLU131C, GLU131K, GLU137K, GLU138K, GLY146K, GLY74C, GLY75C, HIS115C, HIS115K, HIS125C, HIS133C, HIS148K, HIS153K, ILE142K, ILE5C, LEU107K, LEU111K, LEU112K, LEU126C, LEU130K, LEU135K, LEU141K, LEU149K, LEU67C, LYS105K, LYS106K, LYS140K, LYS143K, LYS144K, LYS68C, LYS98K, MET101K, MET145K, MET69C, MET97K, PHE129C, PHE134K, PRO124C, SER119C, SER119K, SER3C, THR122C, THR132C, THR132K, THR150K, TYR9C, VAL139K
• C-L: ALA44C, ALA44L, ALA56C, ALA56L, ALA77C, ALA77L, ARG40C, ARG40L, ARG53C, ARG53L, ARG60C, ARG60L, ARG65C, ARG65L, ARG6C, ARG6L, ARG73C, ARG73L, ARG76C, ARG76L, ASN18L, ASN22C, ASN22L, ASN71C, ASN71L, ASP39C, ASP39L, ASP41C, ASP41L, ASP42C, ASP42L, ASP81C, ASP81L, ASP88C, ASP88L, GLN26C, GLN26L, GLN4C, GLN4L, GLN70C, GLN70L, GLN72C, GLN72L, GLN80C, GLN80L, GLU46C, GLU46L, GLU57C, GLU57L, GLU61C, GLU61L, GLU64C, GLU64L, GLU87C, GLU87L, GLU89C, GLU89L, GLY35C, GLY35L, GLY74C, GLY74L, GLY75C, GLY75L, HIS50C, HIS50L, ILE5C, ILE5L, ILE82C, ILE82L, LEU25C, LEU25L, LEU32C, LEU32L, LEU34C, LEU34L, LEU45C, LEU66C, LEU66L, LEU67C, LEU67L, LEU78C, LEU78L, LYS68C, LYS68L, LYS83C, LYS83L, LYS84C, LYS84L, MET1L, MET69C, MET69L, PHE36C, PHE36L, PHE38C, PHE38L, PHE79C, PHE79L, PRO85C, PRO85L, SER28C, SER28L, SER2C, SER2L, SER33C, SER33L, SER3C, SER3L, SER49C, SER49L, THR30C, THR30L, TRP90C, TRP90L, TYR29C, TYR29L, TYR37C, TYR37L, TYR63C, TYR63L, VAL21C, VAL21L, VAL43C, VAL43L
• C-U: ARG154C, ASP147C, ASP39U, ASP41U, ASP42U, GLU46U, LYS143C, VAL43U
• C-V: ASP128C, ASP128V, ASP136C, GLN4V, GLN7V, GLU131C, GLU131V, HIS115C, HIS125V, LYS105C
• C-W: ARG154W, ASP147W, ASP39C, ASP41C, ASP42C, GLU46C, LYS143W, THR150W, VAL43C
• c-k: ALA102k, ALA110k, ALA116k, ARG6c, ARG73c, ARG76c, ASN108k, ASN151k, ASN71c, ASN8c, ASP113k, ASP123c, ASP128c, ASP128k, ASP136k, ASP147k, CYS127c, CYS127k, GLN109k, GLN4c, GLN70c, GLN72c, GLN7c, GLU104k, GLU131c, GLU131k, GLU137k, GLU138k, GLY146k, GLY74c, HIS115c, HIS115k, HIS125c, HIS133c, HIS148k, HIS153k, ILE142k, ILE5c, LEU107k, LEU111k, LEU112k, LEU126c, LEU130k, LEU135k, LEU141k, LEU149k, LEU67c, LYS105k, LYS106k, LYS140k, LYS143k, LYS144k, LYS68c, LYS98k, MET101k, MET145k, MET69c, MET97k, PHE129c, PHE134k, PRO124c, SER119c, SER119k, SER3c, THR122c, THR132c, THR132k, THR150k, TYR9c, VAL139k
• c-l: ALA44c, ALA44l, ALA56c, ALA56l, ALA77c, ALA77l, ARG40c, ARG40l, ARG53c, ARG53l, ARG60c, ARG60l, ARG65c, ARG65l, ARG6c, ARG6l, ARG73c, ARG73l, ARG76c, ARG76l, ASN18l, ASN22c, ASN22l, ASN71c, ASN71l, ASP39c, ASP39l, ASP41c, ASP41l, ASP42c, ASP42l, ASP81c, ASP81l, ASP88c, ASP88l, GLN26c, GLN26l, GLN4c, GLN4l, GLN70c, GLN70l, GLN72c, GLN72l, GLN80c, GLN80l, GLU46c, GLU46l, GLU57c, GLU57l, GLU61c, GLU61l, GLU64c, GLU64l, GLU87c, GLU87l, GLU89c, GLU89l, GLY35c, GLY35l, GLY74c, GLY74l, GLY75c, GLY75l, HIS50c, HIS50l, ILE5c, ILE5l, ILE82c, ILE82l, LEU25c, LEU25l, LEU32c, LEU32l, LEU34c, LEU34l, LEU66c, LEU66l, LEU67c, LEU67l, LEU78c, LEU78l, LYS68c, LYS68l, LYS83c, LYS83l, LYS84c, LYS84l, MET69c, MET69l, PHE36c, PHE36l, PHE38c, PHE38l, PHE79c, PHE79l, PRO85c, PRO85l, SER28c, SER28l, SER2l, SER33c, SER33l, SER3c, SER3l, SER49c, SER49l, THR30c, THR30l, TRP90c, TRP90l, TYR29c, TYR29l, TYR37c, TYR37l, TYR63c, TYR63l, VAL21c, VAL21l, VAL43c, VAL43l
• c-u: ALA44u, ARG154c, ASN151c, ASP147c, ASP39u, ASP41u, ASP42u, GLU159c, GLU46u, LYS143c, LYS92u
• c-v: ASP128c, ASP128v, ASP136c, GLN4v, GLN7v, GLU131c, GLU131v, HIS115c, HIS125v, LYS105c
• c-w: ASP147w, ASP39c, ASP41c, ASP42c, GLU46c, LYS143w
• D-I: ALA44D, ALA44I, ALA56D, ALA56I, ALA77D, ALA77I, ARG40D, ARG40I, ARG53D, ARG53I, ARG60D, ARG60I, ARG65D, ARG65I, ARG6D, ARG6I, ARG73D, ARG73I, ARG76D, ARG76I, ASN18I, ASN22D, ASN22I, ASN71D, ASN71I, ASP39D, ASP39I, ASP41D, ASP41I, ASP42D, ASP42I, ASP81D, ASP81I, ASP88D, ASP88I, GLN26D, GLN26I, GLN4D, GLN4I, GLN70D, GLN70I, GLN72D, GLN72I, GLN80D, GLN80I, GLU46I, GLU57D, GLU57I, GLU61D, GLU61I, GLU64D, GLU64I, GLU87D, GLU87I, GLU89D, GLU89I, GLY35D, GLY35I, GLY74D, GLY74I, GLY75D, GLY75I, HIS50I, ILE5D, ILE5I, ILE82D, ILE82I, LEU25D, LEU25I, LEU32D, LEU32I, LEU34D, LEU34I, LEU66D, LEU66I, LEU67D, LEU67I, LEU78D, LEU78I, LYS68D, LYS68I, LYS83D, LYS83I, LYS84D, LYS84I, MET1D, MET69D, MET69I, PHE36D, PHE36I, PHE38D, PHE38I, PHE79D, PHE79I, PRO85D, PRO85I, SER28D, SER28I, SER2D, SER33D, SER33I, SER3D, SER3I, SER49D, SER49I, THR30D, THR30I, TRP90D, TRP90I, TYR29D, TYR29I, TYR37D, TYR37I, TYR63D, TYR63I, VAL21D, VAL21I, VAL43D, VAL43I
• D-L: ALA102L, ALA110L, ALA116L, ARG6D, ARG73D, ARG76D, ASN108L, ASN151L, ASN71D, ASN8D, ASP113L, ASP123D, ASP128D, ASP128L, ASP136L, ASP147L, CYS127D, CYS127L, GLN109L, GLN4D, GLN70D, GLN72D, GLN7D, GLU104L, GLU131D, GLU131L, GLU137L, GLU138L, GLY146L, GLY74D, GLY75D, HIS115D, HIS115L, HIS125D, HIS133D, HIS148L, ILE142L, ILE5D, LEU107L, LEU111L, LEU112L, LEU126D, LEU130L, LEU135L, LEU141L, LEU149L, LEU67D, LYS105L, LYS106L, LYS140L, LYS143L, LYS144L, LYS68D, LYS98L, MET101L, MET145L, MET69D, PHE129D, PHE134L, PRO124D, SER119D, SER119L, SER2D, SER3D, THR122D, THR132D, THR132L, THR150L, TYR9D, VAL139L
• D-Q: ALA160D, ALA160Q, ALA44D, ARG154Q, ARG40D, ASN151Q, ASP147Q, ASP39D, ASP41D, ASP42D, GLU159Q, GLU46D, GLY146Q, GLY156D, GLY157D, GLY157Q, GLY161Q, GLY91D, HIS148Q, HIS153Q, ILE142Q, LEU149Q, LEU152D, LEU152Q, LEU155D, LEU45D, LYS143Q, LYS144Q, LYS92D, MET101Q, MET145Q, PHE36D, PHE38D, PRO158Q, PRO94D, THR150Q, THR93D, TYR37D, VAL43D, VAL48D
• D-R: ALA160D, ALA160R, ALA44R, ARG154D, ARG40R, ASN151D, ASP147D, ASP39R, ASP41R, ASP42R, GLU159D, GLU46R, GLY146D, GLY156R, GLY157D, GLY157R, GLY47R, GLY91R, HIS148D, ILE142D, LEU149D, LEU152D, LEU152R, LEU155R, LEU162R, LEU45R, LYS143D, LYS144D, LYS92R, MET101D, MET145D, PHE38R, PRO158D, PRO94R, THR150D, THR93R, TYR37R, VAL43R, VAL48R
• D-W: ARG6W, ASP123W, ASP128D, ASP128W, ASP136D, GLN4W, GLN7W, GLU131D, GLU131W, GLY146D, HIS115D, HIS125W, LYS105D
• d-i: ALA44d, ALA44i, ALA56d, ALA56i, ALA77d, ALA77i, ARG40d, ARG40i, ARG53d, ARG53i, ARG60d, ARG60i, ARG65d, ARG65i, ARG6d, ARG6i, ARG73d, ARG73i, ARG76d, ARG76i, ASN18d, ASN22d, ASN22i, ASN71d, ASN71i, ASP39d, ASP39i, ASP41d, ASP41i, ASP42d, ASP42i, ASP81d, ASP81i, ASP88d, ASP88i, GLN26d, GLN26i, GLN4d, GLN4i, GLN70d, GLN70i, GLN72d, GLN72i, GLN80d, GLN80i, GLU46d, GLU46i, GLU57d, GLU57i, GLU61d, GLU61i, GLU64d, GLU64i, GLU87d, GLU87i, GLU89d, GLU89i, GLY35d, GLY35i, GLY74d, GLY74i, GLY75d, GLY75i, HIS50d, HIS50i, ILE5d, ILE5i, ILE82d, ILE82i, LEU25d, LEU25i, LEU32d, LEU32i, LEU34d, LEU34i, LEU66d, LEU66i, LEU67d, LEU67i, LEU78d, LEU78i, LYS68d, LYS68i, LYS83d, LYS83i, LYS84d, LYS84i, MET69d, MET69i, PHE36d, PHE36i, PHE38d, PHE38i, PHE79d, PHE79i, PRO85d, PRO85i, SER28d, SER28i, SER33d, SER33i, SER3d, SER3i, SER49d, SER49i, THR30d, THR30i, TRP90d, TRP90i, TYR29d, TYR29i, TYR37d, TYR37i, TYR63d, TYR63i, VAL21d, VAL21i, VAL43d, VAL43i
• d-l: ALA110l, ALA116l, ARG121d, ARG6d, ARG73d, ARG76d, ASN108l, ASN151l, ASN71d, ASN8d, ASP113l, ASP123d, ASP128d, ASP128l, ASP136l, ASP147l, CYS127d, CYS127l, GLN109l, GLN4d, GLN70d, GLN72d, GLN7d, GLU104l, GLU131d, GLU131l, GLU137l, GLU138l, GLY146l, GLY74d, HIS115d, HIS115l, HIS125d, HIS133d, HIS133l, HIS148l, HIS153l, ILE142l, ILE5d, LEU107l, LEU111l, LEU112l, LEU126d, LEU130l, LEU135l, LEU141l, LEU149l, LYS105l, LYS106l, LYS140l, LYS143l, LYS144l, LYS68d, LYS98l, MET101l, MET145l, MET69d, PHE129d, PHE134l, PRO124d, SER119d, SER119l, SER3d, THR122d, THR132d, THR132l, THR150l, TYR9d, VAL139l
• d-q: ALA44d, ARG154q, ARG40d, ASN151q, ASP147q, ASP39d, ASP41d, ASP42d, GLU46d, GLY146q, HIS148q, ILE142q, LEU149q, LEU152q, LEU45d, LYS143q, LYS144q, LYS92d, MET101q, MET145q, PHE36d, PHE38d, THR150q, THR93d, VAL43d
• d-r: ALA44r, ARG154d, ARG40r, ASN151d, ASP147d, ASP39-5.3819993.164696, ASP39r, ASP41r, ASP42r, GLU46r, GLY146d, HIS148d, ILE142d, LEU149d, LEU152d, LEU45r, LYS143d, LYS144d, LYS92r, MET101d, MET145d, PHE38r, THR150d, THR93r, VAL43-10.4080232.591900, VAL43r, VAL48r
• d-w: ASP128d, ASP128w, ASP136d, GLN4w, GLN7w, GLU131d, GLU131w, HIS115d, HIS125w, LYS105d
• E-M: ALA102M, ALA110M, ALA116M, ARG6E, ARG73E, ARG76E, ASN108M, ASN151M, ASN71E, ASN8E, ASP113M, ASP123E, ASP128E, ASP128M, ASP136M, ASP147M, CYS127E, CYS127M, GLN109M, GLN4E, GLN70E, GLN72E, GLN7E, GLU104M, GLU131E, GLU131M, GLU137M, GLU138M, GLY146M, GLY74E, GLY75E, HIS115E, HIS115M, HIS125E, HIS133E, HIS133M, HIS148M, ILE142M, ILE5E, LEU107M, LEU111M, LEU112M, LEU114M, LEU126E, LEU130M, LEU135M, LEU141M, LEU149M, LYS105M, LYS106M, LYS140M, LYS143M, LYS144M, LYS68E, LYS98M, MET101M, MET145M, MET69E, MET97M, PHE129E, PHE134M, PRO124E, SER119E, SER119M, SER2E, SER3E, THR122E, THR132E, THR132M, THR150M, TYR9E, VAL139M
• E-P: ALA44E, ALA44P, ALA56E, ALA56P, ALA77E, ALA77P, ARG0E, ARG40E, ARG40P, ARG53E, ARG53P, ARG60E, ARG60P, ARG65E, ARG65P, ARG6E, ARG6P, ARG73E, ARG73P, ARG76E, ARG76P, ASN18E, ASN22E, ASN22P, ASN71E, ASN71P, ASP39E, ASP39P, ASP41E, ASP41P, ASP42E, ASP42P, ASP81E, ASP81P, ASP88E, ASP88P, GLN26E, GLN26P, GLN4E, GLN4P, GLN70E, GLN70P, GLN72E, GLN72P, GLN80E, GLN80P, GLU46E, GLU46P, GLU57E, GLU57P, GLU61E, GLU61P, GLU64E, GLU64P, GLU87E, GLU87P, GLU89E, GLU89P, GLY35E, GLY35P, GLY74E, GLY74P, GLY75E, GLY75P, HIS50E, HIS50P, ILE5E, ILE5P, ILE82E, ILE82P, LEU25E, LEU25P, LEU32E, LEU32P, LEU34E, LEU34P, LEU66E, LEU66P, LEU67E, LEU67P, LEU78E, LEU78P, LYS68E, LYS68P, LYS83E, LYS83P, LYS84E, LYS84P, MET1E, MET1P, MET69E, MET69P, PHE36E, PHE36P, PHE38E, PHE38P, PHE79E, PHE79P, PRO85E, PRO85P, SER28E, SER28P, SER2E, SER2P, SER33E, SER33P, SER3E, SER3P, SER49E, SER49P, THR30E, THR30P, TRP90E, TRP90P, TYR29E, TYR29P, TYR37E, TYR37P, TYR63E, TYR63P, VAL21E, VAL21P, VAL43E, VAL43P
• E-R: ALA102E, ALA110E, ALA116E, ARG6R, ARG73R, ARG76R, ASN108E, ASN151E, ASN71R, ASN8R, ASP113E, ASP123R, ASP128E, ASP128R, ASP136E, ASP147E, CYS127E, CYS127R, GLN109E, GLN4R, GLN70R, GLN72R, GLN7R, GLU104E, GLU131E, GLU131R, GLU137E, GLU138E, GLY146E, GLY74R, HIS115E, HIS115R, HIS125R, HIS133R, HIS148E, HIS153E, ILE142E, ILE5R, LEU107E, LEU111E, LEU112E, LEU126R, LEU130E, LEU135E, LEU141E, LEU149E, LEU152E, LYS105E, LYS106E, LYS140E, LYS143E, LYS144E, LYS68R, LYS98E, MET101E, MET145E, MET69R, MET97E, PHE129R, PHE134E, PRO124R, SER119E, SER119R, SER2R, SER3R, THR122R, THR132E, THR132R, THR150E, TYR9R, VAL139E
• E-U: ASP147U, ASP39E, ASP41E, ASP42E, GLU159U, GLU46E, LYS143U, LYS92E
• E-W: ARG154E, ASP147E, ASP39W, ASP41W, ASP42W, GLU159E, GLU46W, LYS143E, LYS92W, VAL43W
• e-m: ALA102m, ALA110m, ALA116m, ARG6e, ARG73e, ARG76e, ASN108m, ASN151m, ASN71e, ASN8e, ASP113m, ASP123e, ASP128e, ASP128m, ASP136m, ASP147m, CYS127e, CYS127m, GLN109m, GLN4e, GLN70e, GLN72e, GLN7e, GLU104m, GLU131e, GLU131m, GLU137m, GLU138m, GLY146m, GLY74e, HIS115e, HIS115m, HIS125e, HIS133e, HIS133m, HIS148m, HIS153m, ILE142m, ILE5e, LEU107m, LEU111m, LEU112m, LEU126e, LEU130m, LEU135m, LEU141m, LEU149m, LEU67e, LYS105m, LYS106m, LYS140m, LYS143m, LYS144m, LYS68e, LYS98m, MET101m, MET145m, MET69e, MET97m, PHE129e, PHE134m, PRO124e, SER119e, SER119m, SER2e, SER3e, THR122e, THR132e, THR132m, THR150m, TYR9e, VAL139m
• e-p: ALA44e, ALA44p, ALA56e, ALA56p, ALA77e, ALA77p, ARG40e, ARG40p, ARG53e, ARG53p, ARG60e, ARG60p, ARG65e, ARG65p, ARG6e, ARG6p, ARG73e, ARG73p, ARG76e, ARG76p, ASN18p, ASN22e, ASN22p, ASN71e, ASN71p, ASP39e, ASP39p, ASP41e, ASP41p, ASP42e, ASP42p, ASP81e, ASP81p, ASP88e, ASP88p, GLN26e, GLN26p, GLN4e, GLN4p, GLN70e, GLN70p, GLN72e, GLN72p, GLN80e, GLN80p, GLU46e, GLU46p, GLU57e, GLU57p, GLU61e, GLU61p, GLU64e, GLU64p, GLU87e, GLU87p, GLU89e, GLU89p, GLY35e, GLY35p, GLY74e, GLY74p, GLY75e, GLY75p, HIS50e, HIS50p, ILE5e, ILE5p, ILE82e, ILE82p, LEU25e, LEU25p, LEU32e, LEU32p, LEU34e, LEU34p, LEU66e, LEU66p, LEU67e, LEU67p, LEU78e, LEU78p, LYS68e, LYS68p, LYS83e, LYS83p, LYS84e, LYS84p, MET1p, MET69e, MET69p, PHE36e, PHE36p, PHE38e, PHE38p, PHE79e, PHE79p, PRO85e, PRO85p, SER28e, SER28p, SER2e, SER2p, SER33e, SER33p, SER3e, SER3p, SER49e, SER49p, THR30e, THR30p, TRP90e, TRP90p, TYR29e, TYR29p, TYR31p, TYR37e, TYR37p, TYR63e, TYR63p, VAL21e, VAL21p, VAL43e, VAL43p
• e-r: 4-2.2575772.936975GLN, 4-4.9817042.802478GLN, 7-4.6459993.021724GLN, ALA102e, ALA110e, ALA116e, ARG6r, ARG73r, ARG76r, ASN108e, ASN151e, ASN71r, ASN8r, ASP113e, ASP123r, ASP128e, ASP128r, ASP136e, ASP147e, CYS127e, CYS127r, GLN109e, GLN4r, GLN70r, GLN72r, GLN7r, GLU104e, GLU131e, GLU131r, GLU137e, GLU138e, GLY146e, GLY74r, GLY75r, HIS115e, HIS115r, HIS125-9.8594372.874260, HIS125r, HIS133e, HIS133r, HIS148e, HIS153e, ILE142e, ILE5r, LEU107e, LEU111e, LEU112e, LEU126r, LEU130e, LEU135e, LEU141e, LEU149e, LEU67r, LYS105e, LYS106e, LYS140e, LYS143e, LYS144e, LYS68r, LYS98e, MET101e, MET145e, MET69r, MET97e, PHE129r, PHE134e, PRO124r, SER119e, SER119r, SER2r, SER3r, THR122r, THR132e, THR132r, THR150e, TYR9r, VAL139e
• e-u: ARG154u, ASP147u, ASP39e, ASP41e, ASP42e, GLU159u, GLU46e, LYS143u, LYS92e, VAL43e
• e-w: ARG154e, ASP147e, ASP39w, ASP41w, ASP42w, GLU46w, LYS143e, THR150e, VAL43w
• F-M: ALA44F, ALA44M, ALA56F, ALA56M, ALA77F, ALA77M, ARG40F, ARG40M, ARG53F, ARG53M, ARG60F, ARG60M, ARG65F, ARG65M, ARG6F, ARG6M, ARG73F, ARG73M, ARG76F, ARG76M, ASN18F, ASN18M, ASN22F, ASN22M, ASN71F, ASN71M, ASP39F, ASP39M, ASP41F, ASP41M, ASP42F, ASP42M, ASP81F, ASP81M, ASP88F, ASP88M, GLN26F, GLN26M, GLN4F, GLN4M, GLN70F, GLN70M, GLN72F, GLN72M, GLN80F, GLN80M, GLU46F, GLU46M, GLU54F, GLU54M, GLU57F, GLU57M, GLU61F, GLU61M, GLU64F, GLU64M, GLU87F, GLU87M, GLU89F, GLU89M, GLY35F, GLY35M, GLY74F, GLY74M, GLY75F, GLY75M, HIS50F, HIS50M, ILE5F, ILE5M, ILE82F, ILE82M, LEU25F, LEU25M, LEU32F, LEU32M, LEU34F, LEU34M, LEU45M, LEU66F, LEU66M, LEU67F, LEU67M, LEU78F, LEU78M, LYS68F, LYS68M, LYS83F, LYS83M, LYS84F, LYS84M, MET69F, MET69M, PHE36F, PHE36M, PHE38F, PHE38M, PHE79F, PHE79M, PRO85F, PRO85M, SER28F, SER28M, SER2F, SER2M, SER33F, SER33M, SER3F, SER3M, SER49F, SER49M, THR30F, THR30M, TRP90F, TRP90M, TYR29F, TYR29M, TYR31M, TYR37F, TYR37M, TYR63F, TYR63M, VAL21F, VAL21M, VAL43F, VAL43M
• F-N: ALA102N, ALA110N, ALA116N, ARG6F, ARG73F, ARG76F, ASN108N, ASN151N, ASN71F, ASN8F, ASP113N, ASP123F, ASP128F, ASP128N, ASP136N, ASP147N, CYS127F, CYS127N, GLN109N, GLN4F, GLN70F, GLN72F, GLN7F, GLU104N, GLU131F, GLU131N, GLU137N, GLU138N, GLY146N, GLY74F, GLY75F, HIS115F, HIS115N, HIS125F, HIS133F, HIS148N, HIS153N, ILE142N, ILE5F, LEU107N, LEU111N, LEU112N, LEU126F, LEU130N, LEU135N, LEU141N, LEU149N, LYS105N, LYS106N, LYS140N, LYS143N, LYS144N, LYS68F, LYS98N, MET101N, MET145N, MET69F, PHE129F, PHE134N, PRO124F, SER119N, SER2F, SER3F, THR122F, THR132F, THR132N, THR150N, TYR9F, VAL139N
• F-Q: ALA160F, ALA160Q, ALA44Q, ARG154F, ARG40Q, ASN151F, ASP147F, ASP39Q, ASP41Q, ASP42Q, GLU159F, GLU46Q, GLY146F, GLY156Q, GLY157F, GLY157Q, GLY161F, GLY91Q, HIS148F, ILE142F, LEU149F, LEU152F, LEU152Q, LEU155Q, LEU45Q, LYS143F, LYS144F, LYS92Q, MET101F, MET145F, PHE38Q, PRO158F, PRO94Q, THR150F, THR93Q, TYR37Q, VAL43Q
• F-R: ALA160F, ALA160R, ALA44F, ARG154R, ARG40F, ASN151F, ASN151R, ASP147R, ASP39F, ASP41F, ASP42F, GLU159R, GLU164R, GLU46F, GLU54F, GLY146R, GLY156F, GLY157F, GLY157R, GLY161R, GLY163R, GLY47F, GLY91F, HIS148F, HIS148R, HIS50F, ILE142R, LEU149F, LEU149R, LEU152F, LEU152R, LEU155F, LEU162R, LEU45F, LEU55F, LYS143R, LYS144R, LYS92F, MET101R, MET145F, MET145R, MET97F, PHE36F, PHE38F, PHE51F, PHE52F, PRO158R, PRO94F, SER49F, THR150R, THR93F, TYR165R, TYR37F, VAL43F, VAL48F
• F-S: ALA102F, ALA110F, ALA116F, ARG6S, ARG73S, ARG76S, ASN108F, ASN151F, ASN71S, ASN8S, ASP113F, ASP123S, ASP128F, ASP128S, ASP136F, ASP147F, CYS127F, CYS127S, GLN109F, GLN4S, GLN70S, GLN72S, GLN7S, GLU104F, GLU131F, GLU131S, GLU137F, GLU138F, GLY146F, GLY74S, HIS115F, HIS115S, HIS125S, HIS133S, HIS148F, HIS153F, ILE142F, ILE5S, LEU107F, LEU111F, LEU112F, LEU126S, LEU130F, LEU135F, LEU141F, LEU149F, LYS105F, LYS106F, LYS140F, LYS143F, LYS144F, LYS68S, LYS98F, MET101F, MET145F, MET69S, PHE129S, PHE134F, PRO124S, SER119F, SER119S, SER2S, SER3S, THR122S, THR132F, THR132S, THR150F, TYR9S, VAL139F
• f-m: ALA44f, ALA44m, ALA56f, ALA56m, ALA77f, ALA77m, ARG40f, ARG40m, ARG53f, ARG53m, ARG60f, ARG60m, ARG65f, ARG65m, ARG6f, ARG6m, ARG73f, ARG73m, ARG76f, ARG76m, ASN18f, ASN22f, ASN22m, ASN71f, ASN71m, ASP39f, ASP39m, ASP41f, ASP41m, ASP42f, ASP42m, ASP81f, ASP81m, ASP88f, ASP88m, GLN26f, GLN26m, GLN4f, GLN4m, GLN70f, GLN70m, GLN72f, GLN72m, GLN80f, GLN80m, GLU46f, GLU46m, GLU57f, GLU57m, GLU61f, GLU61m, GLU64f, GLU64m, GLU87f, GLU87m, GLU89f, GLU89m, GLY35f, GLY35m, GLY74f, GLY74m, GLY75f, GLY75m, HIS50f, HIS50m, ILE5f, ILE5m, ILE82f, ILE82m, LEU25f, LEU25m, LEU32f, LEU32m, LEU34f, LEU34m, LEU66f, LEU66m, LEU67f, LEU67m, LEU78f, LEU78m, LYS68f, LYS68m, LYS83f, LYS83m, LYS84f, LYS84m, MET69f, MET69m, PHE36f, PHE36m, PHE38f, PHE38m, PHE79f, PHE79m, PRO85f, PRO85m, SER28f, SER28m, SER2f, SER33f, SER33m, SER3f, SER3m, SER49f, SER49m, THR30f, THR30m, TRP90f, TRP90m, TYR29f, TYR29m, TYR31f, TYR37f, TYR37m, TYR63f, TYR63m, VAL21f, VAL21m, VAL43f, VAL43m
• f-n: ALA102n, ALA110n, ALA116n, ARG6f, ARG73f, ARG76f, ASN108n, ASN151n, ASN71f, ASN8f, ASP113n, ASP123f, ASP128f, ASP128n, ASP136n, ASP147n, CYS127f, CYS127n, GLN109n, GLN4f, GLN70f, GLN72f, GLN7f, GLU104n, GLU131f, GLU131n, GLU137n, GLU138n, GLY146n, GLY74f, GLY75f, HIS115f, HIS115n, HIS125f, HIS133f, HIS133n, HIS148n, HIS153n, ILE142n, ILE5f, LEU107n, LEU111n, LEU112n, LEU126f, LEU130n, LEU135n, LEU141n, LEU149n, LEU67f, LYS105n, LYS106n, LYS140n, LYS143n, LYS144n, LYS68f, LYS98n, MET101n, MET145n, MET69f, MET97n, PHE129f, PHE134n, PRO124f, SER119f, SER119n, SER3f, THR122f, THR132f, THR132n, THR150n, TYR9f, VAL139n
• f-q: ALA44q, ARG154f, ARG40q, ASN151f, ASP147f, ASP39q, ASP41q, ASP42q, GLU46q, GLY146f, HIS148f, HIS153f, ILE142f, LEU149f, LEU152f, LEU45q, LYS143f, LYS144f, LYS92q, MET101f, MET145f, PHE38q, THR150f, THR93q, TYR37q, VAL43q, VAL48q
• f-r: ALA44f, ARG154r, ARG40f, ASN151r, ASP147r, ASP39f, ASP41f, ASP42f, GLU46f, GLY146r, GLY91f, HIS148r, ILE142r, LEU149r, LEU152r, LEU155r, LEU45f, LYS143-10.1700662.805584, LYS143r, LYS144r, LYS92f, MET101r, MET145r, PHE36f, PHE38f, THR150-4.8170492.492652, THR150r, THR93f, TYR37f, VAL43f, VAL48f
• f-s: ALA102f, ALA110f, ALA116f, ARG6s, ARG73s, ARG76s, ASN108f, ASN151f, ASN71s, ASN8s, ASP113f, ASP123s, ASP128f, ASP128s, ASP136f, ASP147f, CYS127f, CYS127s, GLN109f, GLN4s, GLN70s, GLN72s, GLN7s, GLU104f, GLU131f, GLU131s, GLU137f, GLU138f, GLY146f, GLY74s, GLY75s, HIS115f, HIS115s, HIS125s, HIS133f, HIS133s, HIS148f, HIS153f, ILE142f, ILE5s, LEU107f, LEU111f, LEU112f, LEU126s, LEU130f, LEU135f, LEU141f, LEU149f, LYS105f, LYS106f, LYS140f, LYS143f, LYS144f, LYS68s, LYS98f, MET101f, MET145f, MET69s, PHE129s, PHE134f, PRO124s, SER119f, SER119s, SER3s, THR122s, THR132f, THR132s, THR150f, TYR9s, VAL139f
• G-N: ALA44G, ALA44N, ALA56G, ALA56N, ALA77G, ALA77N, ARG0G, ARG40G, ARG40N, ARG53G, ARG53N, ARG60G, ARG60N, ARG65G, ARG65N, ARG6G, ARG6N, ARG73G, ARG73N, ARG76G, ARG76N, ASN22G, ASN22N, ASN71G, ASN71N, ASP39G, ASP39N, ASP41G, ASP41N, ASP42G, ASP42N, ASP81G, ASP81N, ASP88G, ASP88N, GLN26G, GLN26N, GLN4G, GLN4N, GLN70G, GLN70N, GLN72G, GLN72N, GLN80G, GLN80N, GLU46G, GLU57G, GLU57N, GLU61G, GLU61N, GLU64G, GLU64N, GLU87G, GLU87N, GLU89G, GLU89N, GLY35G, GLY35N, GLY74G, GLY74N, GLY75G, GLY75N, HIS50G, ILE5G, ILE5N, ILE82G, ILE82N, LEU25G, LEU25N, LEU32G, LEU32N, LEU34G, LEU34N, LEU66G, LEU66N, LEU67G, LEU67N, LEU78G, LEU78N, LYS68G, LYS68N, LYS83G, LYS83N, LYS84G, LYS84N, MET1G, MET1N, MET69G, MET69N, PHE36G, PHE36N, PHE38G, PHE38N, PHE79G, PHE79N, PRO85G, PRO85N, SER28G, SER28N, SER2G, SER33G, SER33N, SER3G, SER3N, SER49G, SER49N, THR30G, THR30N, TRP90G, TRP90N, TYR29G, TYR29N, TYR37G, TYR37N, TYR63G, TYR63N, VAL21G, VAL21N, VAL43G, VAL43N
• G-O: ALA102O, ALA110O, ALA116O, ARG121G, ARG6G, ARG73G, ARG76G, ASN108O, ASN151O, ASN71G, ASN8G, ASP113O, ASP123G, ASP128G, ASP128O, ASP136O, ASP147O, CYS127G, CYS127O, GLN109O, GLN4G, GLN70G, GLN72G, GLN7G, GLU104O, GLU131G, GLU131O, GLU137O, GLU138O, GLY146O, GLY74G, GLY75G, HIS115G, HIS115O, HIS125G, HIS133G, HIS148O, ILE142O, ILE5G, LEU107O, LEU111O, LEU112O, LEU126G, LEU130O, LEU135O, LEU141O, LEU149O, LEU67G, LYS105O, LYS106O, LYS140O, LYS143O, LYS144O, LYS68G, LYS98O, MET101O, MET145O, MET69G, PHE129G, PHE134O, PRO124G, SER119G, SER119O, SER2G, SER3G, THR122G, THR132G, THR132O, THR150O, TYR9G, VAL139O
• G-S: ALA160S, ALA44G, ARG154S, ARG40G, ASN151S, ASP147S, ASP39G, ASP41G, ASP42G, GLU159S, GLU46G, GLY146S, GLY156G, GLY157G, GLY157S, GLY91G, HIS148S, ILE142S, LEU149S, LEU152G, LEU152S, LEU155G, LEU155S, LEU45G, LYS143S, LYS144S, LYS92G, MET101S, MET145S, PHE36G, PHE38G, PRO158S, PRO94G, SER49G, THR150S, THR93G, TYR37G, VAL43G, VAL48G
• G-T: ALA102G, ALA110G, ALA116G, ARG6T, ARG73T, ARG76T, ASN108G, ASN151G, ASN71T, ASN8T, ASP113G, ASP123T, ASP128G, ASP128T, ASP136G, ASP147G, CYS127G, CYS127T, GLN109G, GLN4T, GLN70T, GLN72T, GLN7T, GLU104G, GLU131G, GLU131T, GLU137G, GLU138G, GLY146G, GLY74T, GLY75T, HIS115G, HIS115T, HIS125T, HIS133T, HIS148G, HIS153G, ILE142G, ILE5T, LEU107G, LEU111G, LEU112G, LEU126T, LEU130G, LEU135G, LEU141G, LEU149G, LYS105G, LYS106G, LYS140G, LYS143G, LYS144G, LYS68T, LYS98G, MET101G, MET145G, MET69T, PHE129T, PHE134G, PRO124T, SER119G, SER2T, SER3T, THR122T, THR132G, THR132T, THR150G, TYR9T, VAL139G
• G-X: ARG154G, ASP147G, ASP39X, ASP41X, ASP42X, GLU159G, GLU46X, LYS143G, LYS92X, THR150G, VAL43X
• g-n: ALA44g, ALA44n, ALA56g, ALA56n, ALA77g, ALA77n, ARG40g, ARG40n, ARG53g, ARG53n, ARG60g, ARG60n, ARG65g, ARG65n, ARG6g, ARG6n, ARG73g, ARG73n, ARG76g, ARG76n, ASN18g, ASN22g, ASN22n, ASN71g, ASN71n, ASP39g, ASP39n, ASP41g, ASP41n, ASP42g, ASP42n, ASP81g, ASP81n, ASP88g, ASP88n, GLN26g, GLN26n, GLN4g, GLN4n, GLN70g, GLN70n, GLN72g, GLN72n, GLN80g, GLN80n, GLU46g, GLU46n, GLU57g, GLU57n, GLU61g, GLU61n, GLU64g, GLU64n, GLU87g, GLU87n, GLU89g, GLU89n, GLY35g, GLY35n, GLY74g, GLY74n, GLY75g, GLY75n, HIS50g, HIS50n, ILE5g, ILE5n, ILE82g, ILE82n, LEU23g, LEU25g, LEU25n, LEU32g, LEU32n, LEU34g, LEU34n, LEU66g, LEU66n, LEU67g, LEU67n, LEU78g, LEU78n, LYS68g, LYS68n, LYS83g, LYS83n, LYS84g, LYS84n, MET1n, MET69g, MET69n, PHE36g, PHE36n, PHE38g, PHE38n, PHE79g, PHE79n, PRO85g, PRO85n, SER28g, SER28n, SER2g, SER2n, SER33g, SER33n, SER3g, SER3n, SER49g, SER49n, THR30g, THR30n, TRP90g, TRP90n, TYR29g, TYR29n, TYR31n, TYR37g, TYR37n, TYR63g, TYR63n, VAL21g, VAL21n, VAL43g, VAL43n
• g-o: ALA102o, ALA110o, ALA116o, ARG6g, ARG73g, ARG76g, ASN108o, ASN151o, ASN71g, ASN8g, ASP113o, ASP123g, ASP128g, ASP128o, ASP136o, ASP147o, CYS127g, CYS127o, GLN109o, GLN4g, GLN70g, GLN72g, GLN7g, GLU104o, GLU131g, GLU131o, GLU137o, GLU138o, GLY146o, GLY74g, HIS115g, HIS115o, HIS125g, HIS133g, HIS148o, HIS153o, ILE142o, ILE5g, LEU107o, LEU111o, LEU112o, LEU126g, LEU130o, LEU135o, LEU141o, LEU149o, LYS105o, LYS106o, LYS140o, LYS143o, LYS144o, LYS68g, LYS98o, MET101o, MET145o, MET69g, PHE129g, PHE134o, PRO124g, SER119g, SER119o, SER2g, SER3g, THR122g, THR132g, THR132o, THR150o, TYR9g, VAL139o
• g-s: ALA44g, ARG154s, ARG40g, ASN151s, ASP147s, ASP39g, ASP41g, ASP42g, GLU46g, GLY146s, GLY91g, HIS148s, ILE142s, LEU149s, LEU152s, LEU45g, LYS143s, LYS144s, LYS92g, MET101s, MET145s, PHE36g, PHE38g, THR150s, THR93g, TYR37g, VAL43g, VAL48g
• g-t: ALA102g, ALA110g, ALA116g, ARG6t, ARG73t, ARG76t, ASN108g, ASN71t, ASN8t, ASP128g, ASP128t, ASP136g, ASP147g, GLN109g, GLN4t, GLN70t, GLN72t, GLN7t, GLU104g, GLU131g, GLU131t, GLU137g, GLU138g, GLY146g, GLY74t, GLY75t, HIS115g, HIS125t, HIS148g, ILE142g, ILE5t, LEU107g, LEU111g, LEU112g, LEU135g, LEU141g, LEU149g, LEU67t, LYS105g, LYS106g, LYS140g, LYS143g, LYS144g, LYS68t, LYS98g, MET101g, MET145g, MET69t, MET97g, SER3t, THR150g, TYR9t, VAL139g
• g-x: ASP147g, ASP39x, ASP41x, ASP42x, GLU159g, GLU46x, LYS143g, LYS92x
• H-O: ALA44H, ALA44O, ALA56H, ALA56O, ALA77H, ALA77O, ARG40H, ARG40O, ARG53H, ARG53O, ARG60H, ARG60O, ARG65H, ARG65O, ARG6H, ARG6O, ARG73H, ARG73O, ARG76H, ARG76O, ASN18H, ASN18O, ASN22H, ASN22O, ASN71H, ASN71O, ASP39H, ASP39O, ASP41H, ASP41O, ASP42H, ASP42O, ASP81H, ASP81O, ASP88H, ASP88O, GLN26H, GLN26O, GLN4H, GLN4O, GLN70H, GLN70O, GLN72H, GLN72O, GLN80H, GLN80O, GLU46H, GLU46O, GLU54H, GLU57H, GLU57O, GLU61H, GLU61O, GLU64H, GLU64O, GLU87H, GLU87O, GLU89H, GLU89O, GLY35H, GLY35O, GLY74H, GLY74O, GLY75H, GLY75O, HIS50H, ILE5H, ILE5O, ILE82H, ILE82O, LEU25H, LEU25O, LEU32H, LEU32O, LEU34H, LEU34O, LEU66H, LEU66O, LEU67H, LEU67O, LEU78H, LEU78O, LYS68H, LYS68O, LYS83H, LYS83O, LYS84H, LYS84O, MET1H, MET69H, MET69O, PHE36H, PHE36O, PHE38H, PHE38O, PHE79H, PHE79O, PRO85H, PRO85O, SER28H, SER28O, SER2H, SER2O, SER33H, SER33O, SER3H, SER3O, SER49H, SER49O, THR30H, THR30O, TRP90H, TRP90O, TYR29H, TYR29O, TYR31H, TYR31O, TYR37H, TYR37O, TYR63H, TYR63O, VAL21H, VAL21O, VAL43H, VAL43O
• H-P: ALA110P, ALA116P, ARG6H, ARG73H, ARG76H, ASN108P, ASN151P, ASN71H, ASN8H, ASP113P, ASP123H, ASP128H, ASP128P, ASP136P, ASP147P, CYS127H, CYS127P, GLN109P, GLN4H, GLN70H, GLN72H, GLN7H, GLU104P, GLU131H, GLU131P, GLU137P, GLU138P, GLY146P, GLY74H, GLY75H, HIS115H, HIS115P, HIS125H, HIS133H, HIS148P, HIS153P, ILE142P, ILE5H, LEU107P, LEU111P, LEU112P, LEU126H, LEU130P, LEU135P, LEU141P, LEU149P, LEU67H, LYS105P, LYS106P, LYS140P, LYS143P, LYS144P, LYS68H, LYS98P, MET101P, MET145P, MET69H, MET97P, PHE129H, PHE134P, PRO124H, SER119H, SER119P, SER3H, THR122H, THR132H, THR132P, THR150P, TYR9H, VAL139P
• H-T: ALA44H, ARG154T, ARG40H, ASN151T, ASP147T, ASP39H, ASP41H, ASP42H, GLU46H, GLY146T, GLY156H, GLY157H, GLY157T, HIS148T, ILE142T, LEU149T, LEU152T, LEU155H, LEU45H, LYS143T, LYS144T, LYS92H, MET101T, MET145T, PHE38H, PRO158T, THR150T, THR93H, VAL43H
• H-U: ASP128H, ASP128U, ASP136H, GLN4U, GLN7U, GLU131H, GLU131U, GLY146H, HIS115H, HIS125U, LYS105H, LYS143H, LYS68U
• H-V: ALA44V, ARG154H, ASN151H, ASP147H, ASP39V, ASP41V, ASP42V, GLU159H, GLU46V, LYS143H, LYS92V, THR150H, VAL43V
• h-o: ALA44h, ALA44o, ALA56h, ALA56o, ALA77h, ALA77o, ARG40h, ARG40o, ARG53h, ARG53o, ARG60h, ARG60o, ARG65h, ARG65o, ARG6h, ARG6o, ARG73h, ARG73o, ARG76h, ARG76o, ASN18h, ASN22h, ASN22o, ASN71h, ASN71o, ASP39h, ASP39o, ASP41h, ASP41o, ASP42h, ASP42o, ASP81h, ASP81o, ASP88h, ASP88o, GLN26h, GLN26o, GLN4h, GLN4o, GLN70h, GLN70o, GLN72h, GLN72o, GLN80h, GLN80o, GLU46o, GLU57h, GLU57o, GLU61h, GLU61o, GLU64h, GLU64o, GLU87h, GLU87o, GLU89h, GLU89o, GLY35h, GLY35o, GLY74h, GLY74o, GLY75h, GLY75o, HIS50o, ILE5h, ILE5o, ILE82h, ILE82o, LEU25h, LEU25o, LEU32h, LEU32o, LEU34h, LEU34o, LEU66h, LEU66o, LEU67h, LEU67o, LEU78h, LEU78o, LYS68h, LYS68o, LYS83h, LYS83o, LYS84h, LYS84o, MET69h, MET69o, PHE36h, PHE36o, PHE38h, PHE38o, PHE79h, PHE79o, PRO85h, PRO85o, SER28h, SER28o, SER2h, SER2o, SER33h, SER33o, SER3h, SER3o, SER49h, SER49o, THR30h, THR30o, TRP90h, TRP90o, TYR29h, TYR29o, TYR31h, TYR31o, TYR37h, TYR37o, TYR63h, TYR63o, VAL21h, VAL21o, VAL43h, VAL43o
• h-p: ALA102p, ALA110p, ALA116p, ARG121h, ARG6h, ARG73h, ARG76h, ASN108p, ASN151p, ASN71h, ASN8h, ASP113p, ASP123h, ASP128h, ASP128p, ASP136p, ASP147p, CYS127h, CYS127p, GLN109p, GLN4h, GLN70h, GLN72h, GLN7h, GLU104p, GLU131h, GLU131p, GLU137p, GLU138p, GLY146p, GLY74h, HIS115h, HIS115p, HIS125h, HIS133h, HIS148p, HIS153p, ILE142p, ILE5h, LEU107p, LEU111p, LEU112p, LEU126h, LEU130p, LEU135p, LEU141p, LEU149p, LYS105p, LYS106p, LYS140p, LYS143p, LYS144p, LYS68h, LYS98p, MET101p, MET145p, MET69h, PHE129h, PHE134p, PRO124h, SER119h, SER119p, SER2h, SER3h, THR122h, THR132h, THR132p, THR150p, TYR9h, VAL139p
• h-t: ARG154t, ASP147t, ASP39h, ASP41h, ASP42h, GLU159t, GLU46h, LYS143t, LYS92h, MET101t, VAL43h
• h-u: ASN108h, ASP123u, ASP128h, ASP128u, ASP136h, GLN4u, GLN7u, GLU131h, GLU131u, HIS115h, HIS125u, LYS105h, LYS143h, LYS68u
• h-v: ASP147h, ASP39v, ASP41v, ASP42v, GLU159h, GLU46v, LYS143h, LYS92v
• I-J: ALA160I, ALA160J, ALA44J, ARG154I, ARG40J, ASN151I, ASP147I, ASP39J, ASP41J, ASP42J, GLU159I, GLU46J, GLY146I, GLY156J, GLY157I, GLY157J, GLY91J, HIS148I, ILE142I, LEU149I, LEU152I, LEU152J, LEU155J, LEU45J, LYS143I, LYS144I, LYS92J, MET101I, MET145I, PHE38J, PRO158I, PRO94J, THR150I, THR93J, TYR37J, VAL43J, VAL48J
• I-L: ALA160I, ALA44I, ARG154L, ARG40I, ASN151L, ASP147L, ASP39I, ASP41I, ASP42I, GLU159L, GLU46I, GLY146L, GLY156I, GLY157I, GLY157L, HIS148L, ILE142L, LEU149L, LEU152I, LEU152L, LEU155I, LEU45I, LYS143L, LYS144L, LYS92I, MET101L, MET145L, PHE38I, PRO158L, PRO94I, THR150L, THR93I, TYR37I, VAL43I, VAL48I
• I-Q: ALA102Q, ALA110Q, ALA116Q, ARG6I, ARG73I, ARG76I, ASN108Q, ASN151Q, ASN71I, ASN8I, ASP113Q, ASP123I, ASP128I, ASP128Q, ASP136Q, ASP147Q, CYS127I, CYS127Q, GLN109Q, GLN4I, GLN70I, GLN72I, GLN7I, GLU104Q, GLU131I, GLU131Q, GLU137Q, GLU138Q, GLY146Q, GLY74I, GLY75I, HIS115I, HIS115Q, HIS125I, HIS133I, HIS133Q, HIS148Q, HIS153Q, ILE142Q, ILE5I, LEU107Q, LEU111Q, LEU112Q, LEU126I, LEU130Q, LEU135Q, LEU141Q, LEU149Q, LEU67I, LYS105Q, LYS106Q, LYS140Q, LYS143Q, LYS144Q, LYS68I, LYS98Q, MET101Q, MET145Q, MET69I, PHE129I, PHE134Q, PRO124I, SER119I, SER119Q, SER2I, SER3I, THR122I, THR132I, THR132Q, THR150Q, TYR9I, VAL139Q
• i-j: ALA44j, ARG154i, ARG40j, ASN151i, ASP147i, ASP39j, ASP41j, ASP42j, GLU46j, GLY146i, GLY91j, HIS148i, ILE142i, LEU149i, LEU152i, LEU45j, LYS143i, LYS144i, LYS92j, MET101i, MET145i, PHE36j, PHE38j, THR150i, THR93j, TYR37j, VAL43j
• i-l: ALA44i, ARG154l, ARG40i, ASN151l, ASP147l, ASP39i, ASP41i, ASP42i, GLU46i, GLY146l, HIS148l, ILE142l, LEU149l, LEU152l, LEU155l, LEU45i, LYS143l, LYS144l, LYS92i, MET101l, MET145l, PHE38i, THR150l, THR93i, VAL43i
• i-q: ALA102q, ALA110q, ALA116q, ARG6i, ARG73i, ARG76i, ASN108q, ASN151q, ASN71i, ASN8i, ASP113q, ASP123i, ASP128i, ASP128q, ASP136q, ASP147q, CYS127i, CYS127q, GLN109q, GLN4i, GLN70i, GLN72i, GLN7i, GLU104q, GLU131i, GLU131q, GLU137q, GLU138q, GLY146q, GLY74i, HIS115i, HIS115q, HIS125i, HIS133i, HIS133q, HIS148q, ILE142q, ILE5i, LEU107q, LEU111q, LEU112q, LEU126i, LEU130q, LEU135q, LEU141q, LEU149q, LYS105q, LYS106q, LYS140q, LYS143q, LYS144q, LYS68i, LYS98q, MET101q, MET145q, MET69i, MET97q, PHE129i, PHE134q, PRO124i, SER119i, SER119q, SER3i, THR122i, THR132i, THR132q, THR150q, TYR9i, VAL139q
• J-K: ALA160J, ALA160K, ALA44K, ARG154J, ARG154K, ARG40K, ASN151J, ASN151K, ASP147J, ASP147K, ASP39K, ASP41K, ASP42K, ASP95K, GLU159J, GLU164J, GLU46K, GLY146J, GLY156K, GLY157J, GLY157K, GLY161J, GLY163J, GLY47K, HIS148J, HIS148K, HIS153K, ILE142J, LEU149J, LEU149K, LEU152J, LEU152K, LEU155K, LEU162J, LEU45K, LYS143J, LYS144J, LYS92K, MET101J, MET145J, MET97K, PHE36K, PHE38K, PHE51K, PRO158J, PRO94K, SER49K, THR150J, THR150K, THR93K, VAL43K, VAL48K
• J-X: ASP128J, ASP128X, ASP136X, GLN4J, GLU131J, GLU131X, HIS115X, HIS125J, LYS105X, LYS143X, LYS68J
• j-k: ALA44k, ARG154j, ARG40k, ASN151j, ASP147j, ASP39k, ASP41k, ASP42k, GLU46k, GLY146j, GLY91k, HIS148j, ILE142j, LEU149j, LEU152j, LEU45k, LYS105j, LYS143j, LYS144j, LYS92k, MET101j, MET145j, PHE36k, PHE38k, THR150j, THR93k, VAL43k
• j-x: ASP123j, ASP128j, ASP128x, ASP136x, GLN4j, GLU131j, GLU131x, HIS115x, HIS125j, LYS105x
• K-L: ALA160K, ALA44L, ARG154K, ARG40L, ASN151K, ASP147K, ASP39L, ASP41L, ASP42L, GLU159K, GLU46L, GLY146K, GLY156L, GLY157K, GLY157L, GLY91L, HIS148K, ILE142K, LEU149K, LEU152K, LEU152L, LEU155L, LEU45L, LYS143K, LYS144K, LYS92L, MET101K, MET145K, PHE36L, PHE38L, PRO158K, PRO94L, THR150K, THR93L, TYR37L, VAL43L
• K-V: ASP128K, ASP128V, ASP136V, GLN4K, GLN7K, GLU131K, GLU131V, HIS115V, HIS125K, LYS105V, THR150V
• k-l: ALA44l, ARG154k, ARG40l, ASN151k, ASP147k, ASP39l, ASP41l, ASP42l, GLU46l, GLY146k, HIS148k, HIS153k, ILE142k, LEU149k, LEU152k, LEU45l, LYS143k, LYS144k, LYS92l, MET101k, MET145k, PHE36l, PHE38l, THR150k, THR93l, VAL43l, VAL48l
• k-v: ASP123k, ASP128k, ASP128v, ASP136v, GLN4k, GLN7k, GLU131k, GLU131v, HIS115v, HIS125k, LYS105v, THR150v
• L-W: ARG6L, ASP128L, ASP128W, ASP136W, GLN4L, GLN7L, GLU131L, GLU131W, HIS115W, HIS125L, LYS105W, THR150W
• l-w: ASP128l, ASP128w, ASP136w, GLN7l, GLU131l, GLU131w, HIS115w, HIS125l, LYS105w
• M-N: ALA160N, ALA44M, ARG154N, ARG40M, ASN151N, ASP147N, ASP39M, ASP41M, ASP42M, GLU159M, GLU159N, GLU46M, GLY146N, GLY156M, GLY157M, GLY157N, GLY161N, HIS148N, ILE142N, LEU149N, LEU152M, LEU152N, LEU155M, LEU45M, LYS143N, LYS144N, LYS92M, MET101N, MET145N, PHE38M, PRO158N, PRO94M, SER49M, THR150N, THR93M, VAL43M, VAL48M
• M-P: ALA44P, ARG154M, ARG40P, ASN151M, ASP147M, ASP39P, ASP41P, ASP42P, GLU159M, GLU46P, GLY146M, GLY156P, GLY157M, GLY157P, HIS148M, ILE142M, LEU149M, LEU152M, LEU152P, LEU155P, LEU45P, LYS143M, LYS144M, LYS92P, MET101M, MET145M, PHE36P, PHE38P, PRO158M, PRO94P, THR150M, THR93P, VAL43P, VAL48P
• M-R: ALA102R, ALA110R, ALA116R, ARG6M, ARG73M, ARG76M, ASN108R, ASN151R, ASN71M, ASN8M, ASP113R, ASP123M, ASP128M, ASP128R, ASP136R, ASP147R, CYS127M, CYS127R, GLN109R, GLN4M, GLN70M, GLN72M, GLN7M, GLU104R, GLU131M, GLU131R, GLU137R, GLU138R, GLY146R, GLY74M, HIS115M, HIS115R, HIS125M, HIS133M, HIS133R, HIS148R, HIS153R, ILE142R, ILE5M, LEU107R, LEU111R, LEU112R, LEU126M, LEU130R, LEU135R, LEU141R, LEU149R, LYS105R, LYS106R, LYS140R, LYS143R, LYS144R, LYS68M, LYS98R, MET101R, MET145R, MET69M, PHE129M, PHE134R, PRO124M, SER119M, SER119R, SER2M, SER3M, THR122M, THR132M, THR132R, THR150R, TYR9M, VAL139R
• m-n: ALA44m, ARG154n, ARG40m, ASN151n, ASP147n, ASP39m, ASP41m, ASP42m, GLU46m, GLY146n, GLY47m, GLY91m, HIS148n, ILE142n, LEU149n, LEU152n, LEU45m, LYS143n, LYS144n, LYS92m, MET101n, MET145n, PHE38m, THR150n, THR93m, TYR37m, VAL43m, VAL48m
• m-p: ALA160m, ALA44p, ARG154m, ARG40p, ASN151m, ASP147m, ASP39p, ASP41p, ASP42p, GLU159m, GLU46p, GLY146m, GLY156p, GLY157m, GLY157p, GLY91p, HIS148m, ILE142m, LEU149m, LEU152m, LEU152p, LEU155m, LEU155p, LEU45p, LYS143m, LYS144m, LYS92p, MET101m, MET145m, PHE36p, PHE38p, PRO158m, PRO94p, SER49p, THR150m, THR93p, TYR37p, VAL43p
• m-r: ALA102r, ALA110r, ALA116r, ARG6m, ARG73m, ARG76m, ASN108r, ASN151r, ASN71m, ASN8m, ASP113r, ASP123m, ASP128m, ASP128r, ASP136r, ASP147r, CYS127m, CYS127r, GLN109r, GLN4m, GLN70m, GLN72m, GLN7m, GLU104r, GLU131m, GLU131r, GLU137r, GLU138r, GLY146-2.6393743.237817, GLY146r, GLY74m, HIS115m, HIS115r, HIS125m, HIS133m, HIS148r, HIS153r, ILE142r, ILE5m, LEU107r, LEU111r, LEU112r, LEU126m, LEU130r, LEU135r, LEU141r, LEU149r, LEU67m, LYS105-3.3319832.908505, LYS105-5.2344972.983007, LYS105r, LYS106r, LYS140r, LYS143r, LYS144r, LYS68m, LYS98r, MET101r, MET145r, MET69m, PHE129m, PHE134r, PRO124m, SER119r, SER2m, SER3m, THR122m, THR132m, THR132r, THR150r, TYR9m, VAL139r
• N-O: ALA160N, ALA44N, ARG154O, ARG40N, ASN151O, ASP147O, ASP39N, ASP41N, ASP42N, GLU46N, GLY146O, GLY156N, GLY157N, GLY157O, GLY47N, GLY91N, HIS148O, HIS153O, ILE142O, LEU149O, LEU152O, LEU155N, LEU45N, LYS143O, LYS144O, LYS92N, MET101O, MET145O, PHE36N, PHE38N, PRO158O, SER49N, THR150O, THR93N, TYR37N, VAL43N, VAL48N
• N-S: ALA102S, ALA110S, ALA116S, ARG6N, ARG73N, ARG76N, ASN108S, ASN151S, ASN71N, ASN8N, ASP113S, ASP123N, ASP128N, ASP128S, ASP136S, ASP147S, CYS127N, CYS127S, GLN109S, GLN4N, GLN70N, GLN72N, GLN7N, GLU104S, GLU131N, GLU131S, GLU137S, GLU138S, GLY146S, GLY74N, HIS115N, HIS115S, HIS125N, HIS133N, HIS133S, HIS148S, ILE142S, ILE5N, LEU107S, LEU111S, LEU112S, LEU126N, LEU130S, LEU135S, LEU141S, LEU149S, LEU67N, LYS105S, LYS106S, LYS140S, LYS143S, LYS144S, LYS68N, LYS98S, MET101S, MET145S, MET69N, MET97S, PHE129N, PHE134S, PRO124N, SER119N, SER119S, SER2N, SER3N, THR122N, THR132N, THR132S, THR150S, TYR9N, VAL139S
• n-o: ALA44n, ARG154o, ARG40n, ASN151o, ASP147o, ASP39n, ASP41n, ASP42n, GLU46n, GLY146o, HIS148o, ILE142o, LEU149o, LEU152o, LEU45n, LYS105o, LYS143o, LYS144o, LYS92n, MET101o, MET145o, PHE36n, PHE38n, THR150o, THR93n, VAL43n, VAL48n
• n-s: ALA102s, ALA110s, ALA116s, ARG6n, ARG73n, ARG76n, ASN108s, ASN151s, ASN71n, ASN8n, ASP113s, ASP123n, ASP128n, ASP128s, ASP136s, ASP147s, CYS127n, CYS127s, GLN109s, GLN4n, GLN70n, GLN72n, GLN7n, GLU104s, GLU131n, GLU131s, GLU137s, GLU138s, GLY146s, GLY74n, HIS115n, HIS115s, HIS125n, HIS133n, HIS148s, HIS153s, ILE142s, ILE5n, LEU107s, LEU111s, LEU112s, LEU126n, LEU130s, LEU135s, LEU141s, LEU149s, LYS105s, LYS106s, LYS140s, LYS143s, LYS144s, LYS68n, LYS98s, MET101s, MET145s, MET69n, PHE129n, PHE134s, PRO124n, SER119n, SER119s, SER2n, SER3n, THR122n, THR132n, THR132s, THR150s, TYR9n, VAL139s
• O-P: ALA44O, ARG154P, ARG40O, ASN151P, ASP147P, ASP39O, ASP41O, ASP42O, GLU46O, GLY146P, GLY156O, GLY157O, GLY157P, GLY47O, GLY91O, HIS148P, ILE142P, LEU149P, LEU152O, LEU152P, LEU155O, LEU45O, LYS143P, LYS144P, LYS92O, MET101P, MET145P, PHE36O, PHE38O, PRO158P, PRO94O, THR150P, THR93O, TYR37O, VAL43O
• O-T: ALA110T, ALA116T, ARG6O, ARG73O, ARG76O, ASN108T, ASN151T, ASN71O, ASN8O, ASP113T, ASP123O, ASP128O, ASP128T, ASP136T, ASP147T, CYS127O, CYS127T, GLN109T, GLN4O, GLN70O, GLN72O, GLN7O, GLU104T, GLU131O, GLU131T, GLU137T, GLU138T, GLY146T, GLY74O, GLY75O, HIS115O, HIS115T, HIS125O, HIS133O, HIS148T, HIS153T, ILE142T, ILE5O, LEU107T, LEU111T, LEU112T, LEU114T, LEU126O, LEU130T, LEU135T, LEU141T, LEU149T, LYS105T, LYS106T, LYS140T, LYS143T, LYS144T, LYS68O, LYS98T, MET101T, MET145T, MET69O, PHE129O, PHE134T, PRO124O, SER119O, SER119T, SER3O, THR122O, THR132O, THR132T, THR150T, TYR9O, VAL139T
• o-p: ALA44o, ARG154p, ARG40o, ASN151p, ASP147p, ASP39o, ASP41o, ASP42o, GLU46o, GLY146p, GLY156o, GLY157p, GLY91o, HIS148p, ILE142p, LEU149p, LEU152p, LEU155o, LEU45o, LYS143p, LYS144p, LYS92o, MET101p, MET145p, PHE36o, PHE38o, PRO158p, SER49o, THR150p, THR93o, VAL43o, VAL48o
• o-t: ALA102t, ARG6o, ASP123o, ASP128o, ASP128t, ASP136t, GLN4o, GLN7o, GLU104t, GLU131o, GLU131t, HIS115t, HIS125o, ILE5o, LYS105t, LYS98t, MET101t, SER3o
• P-U: ARG6P, ASP128P, ASP128U, ASP136U, GLN7P, GLU131P, GLU131U, HIS115U, HIS125P, LYS105U
• p-u: ASP128p, ASP128u, ASP136u, GLN4p, GLN7p, GLU131p, GLU131u, HIS115u, HIS125p, LYS105u, LYS143u, LYS68p, THR150u
• Q-S: ALA44Q, ALA44S, ALA56Q, ALA56S, ALA77Q, ALA77S, ARG40Q, ARG40S, ARG53Q, ARG53S, ARG60Q, ARG60S, ARG65Q, ARG65S, ARG6Q, ARG6S, ARG73Q, ARG73S, ARG76Q, ARG76S, ASN18S, ASN22Q, ASN22S, ASN71Q, ASN71S, ASP39Q, ASP39S, ASP41Q, ASP41S, ASP42Q, ASP42S, ASP81Q, ASP81S, ASP88Q, ASP88S, GLN26Q, GLN26S, GLN4Q, GLN4S, GLN70Q, GLN70S, GLN72Q, GLN72S, GLN80Q, GLN80S, GLU46Q, GLU46S, GLU57Q, GLU57S, GLU61Q, GLU61S, GLU64Q, GLU64S, GLU87Q, GLU87S, GLU89Q, GLU89S, GLY35Q, GLY35S, GLY74Q, GLY74S, GLY75Q, GLY75S, HIS50Q, HIS50S, ILE5Q, ILE5S, ILE82Q, ILE82S, LEU25Q, LEU25S, LEU32Q, LEU32S, LEU34Q, LEU34S, LEU45Q, LEU66Q, LEU66S, LEU67Q, LEU67S, LEU78Q, LEU78S, LYS68Q, LYS68S, LYS83Q, LYS83S, LYS84Q, LYS84S, MET1S, MET69Q, MET69S, PHE36Q, PHE36S, PHE38Q, PHE38S, PHE79Q, PHE79S, PRO85Q, PRO85S, SER28Q, SER28S, SER2Q, SER2S, SER33Q, SER33S, SER3Q, SER3S, SER49Q, SER49S, THR30Q, THR30S, TRP90Q, TRP90S, TYR29Q, TYR29S, TYR31S, TYR37Q, TYR37S, TYR63Q, TYR63S, VAL21Q, VAL21S, VAL43Q, VAL43S
• q-s: ALA44q, ALA44s, ALA56q, ALA56s, ALA77q, ALA77s, ARG40q, ARG40s, ARG53q, ARG53s, ARG60q, ARG60s, ARG65q, ARG65s, ARG6q, ARG6s, ARG73q, ARG73s, ARG76q, ARG76s, ASN18q, ASN18s, ASN22q, ASN22s, ASN71q, ASN71s, ASP39q, ASP39s, ASP41q, ASP41s, ASP42q, ASP42s, ASP81q, ASP81s, ASP88q, ASP88s, GLN26q, GLN26s, GLN4q, GLN4s, GLN70q, GLN70s, GLN72q, GLN72s, GLN80q, GLN80s, GLU14s, GLU46q, GLU46s, GLU57q, GLU57s, GLU61q, GLU61s, GLU64q, GLU64s, GLU87q, GLU87s, GLU89q, GLU89s, GLY35q, GLY35s, GLY74q, GLY74s, GLY75q, GLY75s, HIS50q, HIS50s, ILE5q, ILE5s, ILE82q, ILE82s, LEU23q, LEU25q, LEU25s, LEU32q, LEU32s, LEU34q, LEU34s, LEU66q, LEU66s, LEU67q, LEU67s, LEU78q, LEU78s, LYS68q, LYS68s, LYS83q, LYS83s, LYS84q, LYS84s, MET69q, MET69s, PHE36q, PHE36s, PHE38q, PHE38s, PHE79q, PHE79s, PRO85q, PRO85s, SER28q, SER28s, SER2q, SER33q, SER33s, SER3q, SER3s, SER49q, SER49s, THR30q, THR30s, TRP90q, TRP90s, TYR29q, TYR29s, TYR37q, TYR37s, TYR63q, TYR63s, VAL21q, VAL21s, VAL43q, VAL43s
• R-W: ARG40R, ARG40W, ARG53R, ARG53W, ARG60R, ARG60W, ARG6R, ARG6W, ARG76R, ARG76W, ASN71R, ASN71W, ASP39R, ASP39W, ASP41R, ASP41W, ASP42R, ASP42W, ASP81R, ASP81W, GLN80R, GLU57R, GLU57W, GLU64R, GLU64W, GLU89R, GLU89W, ILE82R, ILE82W, LYS68R, LYS68W, LYS83R, LYS83W, LYS84R, LYS84W, PHE36R, PHE36W, TYR29W
• r-w: ARG40r, ARG40w, ARG53-4.5184523.224762, ARG53r, ARG53w, ARG60r, ARG60w, ARG6r, ARG6w, ARG76r, ARG76w, ASN71-6.4431682.878838, ASP39r, ASP39w, ASP41r, ASP41w, ASP42r, ASP42w, ASP81-11.2656132.913384, ASP81r, ASP81w, GLU57r, GLU57w, GLU64-4.9476003.000891, GLU64r, GLU64w, GLU89r, GLU89w, ILE82-11.9961802.817084, ILE82-12.7035012.856930, LYS68r, LYS68w, LYS83r, LYS83w, LYS84-13.4052102.802031, LYS84r, LYS84w, PHE36-4.8948932.971251, TYR29-8.0614682.820392
• T-X: ARG40T, ARG40X, ARG53T, ARG53X, ARG60T, ARG60X, ARG6T, ARG6X, ARG76T, ARG76X, ASN71T, ASN71X, ASP39T, ASP39X, ASP41T, ASP41X, ASP42T, ASP42X, ASP81T, ASP81X, GLN80X, GLU57T, GLU57X, GLU64T, GLU64X, GLU89T, GLU89X, ILE82T, ILE82X, LYS68T, LYS68X, LYS83T, LYS83X, LYS84T, LYS84X, PHE36T, PHE36X, SER3T, TYR29T
• t-x: ARG40t, ARG40x, ARG53t, ARG53x, ARG60t, ARG60x, ARG6t, ARG6x, ARG76t, ARG76x, ASN71t, ASN71x, ASP39t, ASP39x, ASP41t, ASP41x, ASP42t, ASP42x, ASP81t, ASP81x, GLN4x, GLN80t, GLU57t, GLU57x, GLU64t, GLU64x, GLU89t, GLU89x, ILE82t, ILE82x, LYS68t, LYS68x, LYS83t, LYS83x, LYS84t, LYS84x, PHE36t, PHE36x, TYR29x
• U-V: ARG40U, ARG40V, ARG53U, ARG53V, ARG60U, ARG60V, ARG6U, ARG6V, ARG76U, ARG76V, ASN71U, ASP39U, ASP39V, ASP41U, ASP41V, ASP42U, ASP42V, ASP81U, ASP81V, GLN80U, GLU57U, GLU57V, GLU64U, GLU64V, GLU89U, GLU89V, ILE82U, ILE82V, LYS68U, LYS68V, LYS83U, LYS83V, LYS84U, LYS84V, PHE36V, TYR29V
• u-v: ARG40u, ARG40v, ARG53u, ARG53v, ARG60u, ARG60v, ARG6u, ARG6v, ARG76u, ARG76v, ASN71u, ASN71v, ASP39u, ASP39v, ASP41u, ASP41v, ASP42u, ASP42v, ASP81u, ASP81v, GLN4v, GLU57u, GLU57v, GLU64u, GLU64v, GLU89u, GLU89v, ILE82u, ILE82v, LYS68u, LYS68v, LYS83u, LYS83v, LYS84u, LYS84v, PHE36u, PHE36v