3HWX

crystal structure of menaquinone synthesis protein mend from e. coli in complex with thdp

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: R-Z
  • Int. Res.: 143
  • Norm. En. per Res.: -5.4066
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-63.6666	18.694	-914.428	-959.4006	335	44	22	37953	6	66	64
A-I	-123.4218	-119.6723	-467.37	-710.464	140	33	1	17038	9	104	128
A-J	0.0	-27.1337	-84.2267	-111.3604	63	2	0	4135	0	18	16
A-S	0.0	6.2905	-16.8367	-10.5462	41	0	0	1263	0	19	18
A-1	0.0	-18.718	-71.4634	-90.1814	40	1	2	2678	0	21	17
B-I	0.0	-31.883	-85.5805	-117.4635	64	3	0	4151	0	20	16
B-J	-183.4109	-159.9574	-399.189	-742.5573	144	47	1	17206	16	100	124
I-J	-90.367	10.0383	-899.802	-980.1308	329	59	25	38150	6	66	65
I-S	0.0	-19.0504	-66.6857	-85.7361	40	0	2	2891	0	22	17
R-S	-65.4773	16.6014	-950.535	-999.4109	331	44	24	38559	7	65	64
R-Z	-176.4274	-112.8373	-483.876	-773.1406	143	38	1	17354	10	106	130
R-1	-9.5608	-28.4081	-95.405	-133.3739	65	4	0	4398	0	18	16
S-Z	0.0	-34.2326	-85.9901	-120.2228	61	7	0	4418	0	18	16
S-1	-134.2862	-107.2533	-459.398	-700.9375	142	29	1	16891	19	103	125
Z-1	-97.3367	16.1856	-927.396	-1008.547	332	51	21	38060	6	66	66

Interface residues

• A-B: ALA116A, ALA116B, ALA119A, ALA119B, ALA127A, ALA127B, ALA299A, ALA29A, ALA29B, ALA319A, ALA319B, ALA40A, ALA40B, ALA415A, ALA415B, ALA41A, ALA41B, ALA42A, ALA42B, ALA445A, ALA445B, ALA451A, ALA451B, ALA453A, ALA453B, ALA500A, ALA500B, ALA501A, ALA501B, ALA502A, ALA502B, ALA82A, ALA82B, ALA84A, ALA84B, ALA89A, ALA89B, ALA93A, ALA93B, ARG107A, ARG107B, ARG121A, ARG121B, ARG228A, ARG228B, ARG315A, ARG315B, ARG325A, ARG325B, ARG33A, ARG33B, ARG395A, ARG395B, ARG413A, ARG413B, ARG430B, ARG456A, ARG456B, ARG485A, ARG485B, ARG487A, ARG487B, ARG56A, ARG56B, ARG8A, ARG8B, ASN117A, ASN117B, ASN390A, ASN390B, ASN412A, ASN412B, ASN450A, ASN450B, ASN468A, ASN468B, ASN494A, ASN494B, ASN85A, ASN85B, ASP113A, ASP113B, ASP317A, ASP317B, ASP419A, ASP419B, ASP442A, ASP442B, ASP448A, ASP448B, ASP54A, ASP54B, CYS114A, CYS114B, CYS27A, CYS27B, GLN118A, GLN118B, GLN122A, GLN122B, GLN284A, GLN284B, GLN296A, GLN298A, GLN298B, GLN457A, GLN457B, GLN482A, GLN482B, GLN493A, GLN493B, GLU110A, GLU110B, GLU172A, GLU172B, GLU313A, GLU313B, GLU43A, GLU43B, GLU484A, GLU484B, GLU486A, GLU486B, GLU498A, GLU498B, GLU505A, GLU505B, GLU534A, GLU534B, GLU55A, GLU55B, GLU92A, GLU92B, GLY115A, GLY115B, GLY124A, GLY124B, GLY176A, GLY176B, GLY314A, GLY314B, GLY31A, GLY31B, GLY414A, GLY414B, GLY417A, GLY417B, GLY420A, GLY420B, GLY471A, GLY471B, GLY472A, GLY472B, GLY57A, GLY57B, GLY59A, GLY80A, GLY80B, GLY94A, GLY94B, HIS129A, HIS129B, HIS320A, HIS320B, HIS496A, HIS496B, HIS499A, HIS499B, HIS49A, HIS49B, HIS50A, HIS50B, HIS52A, HIS52B, HIS60A, HIS60B, ILE112A, ILE112B, ILE120A, ILE120B, ILE26A, ILE26B, ILE28A, ILE28B, ILE308A, ILE308B, ILE312A, ILE312B, ILE418A, ILE418B, ILE474A, ILE474B, ILE48A, ILE48B, ILE76A, ILE76B, ILE91A, ILE91B, LEU111A, LEU111B, LEU174A, LEU174B, LEU253A, LEU253B, LEU289A, LEU289B, LEU295A, LEU295B, LEU316A, LEU316B, LEU36A, LEU36B, LEU37A, LEU37B, LEU39A, LEU39B, LEU443A, LEU443B, LEU446A, LEU446B, LEU449A, LEU449B, LEU452A, LEU452B, LEU454A, LEU454B, LEU478A, LEU478B, LEU490A, LEU490B, LEU58A, LEU58B, LEU63A, LEU63B, LEU86A, LEU86B, LEU90A, LEU90B, LEU95A, LEU95B, LYS292A, LYS292B, MET125A, MET125B, MET491A, MET491B, MET503A, MET503B, PHE126A, PHE126B, PHE475A, PHE475B, PHE47A, PHE47B, PHE488A, PHE488B, PHE497A, PHE497B, PHE504A, PHE504B, PHE53A, PHE53B, PRO108A, PRO108B, PRO109A, PRO109B, PRO123A, PRO123B, PRO130A, PRO130B, PRO30A, PRO30B, PRO318A, PRO318B, PRO479A, PRO479B, PRO481A, PRO481B, PRO492A, PRO492B, PRO88A, PRO88B, SER128A, SER128B, SER287A, SER287B, SER288A, SER288B, SER32A, SER32B, SER34A, SER34B, SER391A, SER416A, SER416B, SER444A, SER444B, SER483A, SER483B, SER79A, SER79B, THR131A, THR131B, THR290A, THR290B, THR35A, THR35B, THR38A, THR38B, THR480A, THR480B, THR51A, THR51B, THR78A, THR78B, THR81A, THR81B, TYR175A, TYR175B, TYR447A, TYR447B, TYR489A, TYR489B, TYR87A, TYR87B, VAL394A, VAL394B, VAL466A, VAL466B, VAL495A, VAL495B, VAL77A, VAL77B, VAL83A, VAL83B
• A-I: ALA145A, ALA145I, ALA155A, ALA155I, ALA203A, ALA203I, ALA299A, ALA299I, ALA319A, ALA319I, ALA328A, ALA328I, ARG146A, ARG146I, ARG188A, ARG188I, ARG201A, ARG201I, ARG205A, ARG205I, ARG20A, ARG20I, ARG212A, ARG212I, ARG315A, ARG315I, ARG322A, ARG322I, ARG324A, ARG324I, ARG325A, ARG325I, ASP153A, ASP153I, ASP191A, ASP191I, ASP195A, ASP195I, ASP196A, ASP196I, ASP213A, ASP213I, ASP317A, ASP317I, GLN194A, GLN194I, GLN211A, GLN211I, GLU202A, GLU202I, GLU207A, GLU207I, GLU209A, GLU209I, GLU302A, GLU302I, GLU304I, GLU305A, GLU305I, GLU313A, GLU313I, GLY157A, GLY190A, GLY190I, GLY314A, GLY314I, GLY323A, GLY323I, HIS132A, HIS132I, HIS154A, HIS154I, HIS160A, HIS160I, HIS320A, HIS320I, HIS321A, HIS321I, ILE134A, ILE134I, ILE143A, ILE143I, ILE152A, ILE152I, ILE281I, ILE308A, ILE308I, ILE312A, ILE312I, ILE327A, ILE327I, LEU148A, LEU148I, LEU189A, LEU189I, LEU200A, LEU200I, LEU206A, LEU206I, LEU316A, LEU316I, LEU326A, LEU326I, LYS197A, LYS197I, LYS210A, PRO144A, PRO144I, PRO198A, PRO198I, PRO204A, PRO204I, PRO318A, PRO318I, SER150A, SER150I, SER208A, SER208I, SER300A, SER300I, THR151A, THR151I, THR158A, THR158I, TRP147A, TRP147I, TRP192A, TRP192I, TRP193A, TRP193I, TRP199A, TRP199I, TRP217A, TRP217I, TRP307A, TRP307I, TYR306A, TYR306I, VAL149A, VAL149I
• A-J: ALA171A, ALA171J, ARG121A, ARG121J, ARG138A, ARG138J, ARG146A, ASP113A, ASP113J, ASP142A, ASP142J, CYS114A, CYS114J, GLN141A, GLN141J, GLU110A, GLU110J, HIS132A, HIS154A, HIS154J, ILE112A, ILE112J, ILE134A, ILE134J, ILE143A, ILE143J, LEU111A, LEU111J, LEU136A, LEU136J, LEU148A, LEU148J, LEU200A, LEU200J, MET1J, PRO108A, PRO108J, PRO109A, PRO109J, PRO123A, PRO123J, PRO137A, PRO137J, PRO139A, PRO139J, PRO144A, PRO144J, SER133A, SER133J, SER135A, SER135J, SER150A, SER150J, THR140A, THR140J, THR151A, THR151J, TRP10A, TRP10J, TRP147A, TRP147J, VAL3A, VAL3J
• A-S: ALA460A, ALA460S, ARG201A, ARG201S, ARG205S, ARG526A, ARG526S, ASP195A, ASP195S, ASP196A, ASP196S, ASP523S, GLN194A, GLN194S, GLN383A, GLU232A, GLU232S, GLU335A, GLU335S, GLU382A, LEU239A, LEU239S, LYS197A, LYS197S, LYS235A, LYS235S, LYS236A, LYS236S, LYS341A, LYS341S, PRO461A, PRO461S, PRO528A, PRO528S, SER459A, SER459S, THR527A, THR527S, THR529S, TRP525A, TRP525S
• A-1: ALA520A, ALA522A, ALA524A, ARG2121, ARG2181, ARG3221, ARG3241, ARG526A, ASP2131, ASP523A, GLN2111, GLN2191, GLN2801, GLN515A, GLU2091, GLU3041, GLU3051, GLU3401, GLU382A, GLU516A, GLU518A, HIS509A, LEU380A, LEU517A, LYS2101, LYS2201, LYS3411, LYS507A, PHE2151, PHE2161, PHE521A, PRO381A, THR519A, THR527A, TRP2141, TRP2171, TRP3071, TRP514A, TRP525A, TYR379A
• B-I: ALA171B, ALA171I, ARG121B, ARG121I, ARG138B, ARG138I, ARG146B, ARG146I, ASP113B, ASP113I, ASP142B, ASP142I, CYS114B, CYS114I, GLN141B, GLN141I, GLU110B, GLU110I, HIS132B, HIS132I, HIS154B, HIS154I, ILE112B, ILE112I, ILE134B, ILE134I, ILE143B, ILE143I, LEU111B, LEU111I, LEU136B, LEU136I, LEU148I, LEU200B, LEU200I, MET1I, PRO108B, PRO108I, PRO109B, PRO109I, PRO123B, PRO123I, PRO137B, PRO137I, PRO139B, PRO139I, PRO144B, PRO144I, SER133B, SER133I, SER135B, SER135I, SER150B, SER150I, THR140B, THR140I, THR151B, THR151I, TRP10B, TRP10I, TRP147B, TRP147I, VAL3B, VAL3I
• B-J: ALA145B, ALA145J, ALA155B, ALA155J, ALA203B, ALA203J, ALA299B, ALA299J, ALA319B, ALA319J, ALA328B, ALA328J, ARG146B, ARG146J, ARG188B, ARG188J, ARG201B, ARG201J, ARG205B, ARG205J, ARG20B, ARG20J, ARG212B, ARG212J, ARG315B, ARG315J, ARG322B, ARG322J, ARG324B, ARG324J, ARG325B, ARG325J, ASP153B, ASP153J, ASP191B, ASP191J, ASP195B, ASP195J, ASP196B, ASP196J, ASP213B, ASP213J, ASP317B, ASP317J, CYS301B, GLN194B, GLN194J, GLN211B, GLN211J, GLU202B, GLU202J, GLU207B, GLU207J, GLU209B, GLU209J, GLU302B, GLU302J, GLU304B, GLU304J, GLU305B, GLU305J, GLU313B, GLU313J, GLY190B, GLY190J, GLY314B, GLY314J, GLY323B, GLY323J, HIS132B, HIS132J, HIS154B, HIS154J, HIS160B, HIS160J, HIS320B, HIS320J, HIS321B, HIS321J, ILE134B, ILE134J, ILE143B, ILE143J, ILE152B, ILE152J, ILE281B, ILE308B, ILE308J, ILE312B, ILE312J, ILE327B, ILE327J, LEU148B, LEU148J, LEU189B, LEU189J, LEU200B, LEU200J, LEU206B, LEU206J, LEU316B, LEU316J, LEU326B, LEU326J, LEU336B, LYS197B, LYS197J, LYS210B, LYS210J, PRO144B, PRO144J, PRO198B, PRO198J, PRO204B, PRO204J, PRO303B, PRO318B, PRO318J, SER150B, SER150J, SER208B, SER208J, SER300B, SER300J, THR151B, THR151J, THR158B, THR158J, TRP147B, TRP147J, TRP192B, TRP192J, TRP193B, TRP193J, TRP199B, TRP199J, TRP217B, TRP217J, TRP307B, TRP307J, TYR306B, TYR306J, VAL149B, VAL149J
• I-J: ALA116I, ALA116J, ALA119I, ALA119J, ALA127I, ALA127J, ALA299I, ALA29I, ALA29J, ALA319I, ALA319J, ALA40I, ALA40J, ALA415I, ALA415J, ALA41I, ALA41J, ALA42I, ALA42J, ALA445I, ALA445J, ALA451I, ALA451J, ALA453I, ALA453J, ALA500I, ALA500J, ALA501I, ALA501J, ALA502I, ALA502J, ALA82I, ALA82J, ALA84I, ALA84J, ALA89I, ALA89J, ALA93I, ALA93J, ARG107I, ARG107J, ARG121I, ARG121J, ARG228I, ARG228J, ARG315I, ARG315J, ARG325I, ARG325J, ARG33I, ARG33J, ARG395I, ARG395J, ARG413I, ARG413J, ARG430I, ARG456I, ARG456J, ARG485I, ARG485J, ARG487I, ARG487J, ARG56I, ARG56J, ARG8I, ARG8J, ASN117I, ASN117J, ASN390I, ASN390J, ASN412I, ASN412J, ASN44J, ASN450I, ASN450J, ASN468I, ASN468J, ASN470J, ASN494I, ASN494J, ASN85I, ASN85J, ASP113I, ASP113J, ASP317I, ASP317J, ASP419I, ASP419J, ASP442I, ASP442J, ASP448I, ASP448J, ASP54I, ASP54J, CYS114I, CYS114J, CYS27I, CYS27J, GLN118I, GLN118J, GLN122I, GLN122J, GLN284I, GLN284J, GLN298I, GLN457I, GLN457J, GLN482I, GLN482J, GLN493I, GLN493J, GLU110I, GLU110J, GLU172I, GLU172J, GLU313I, GLU43I, GLU43J, GLU484I, GLU484J, GLU486I, GLU486J, GLU498I, GLU498J, GLU505I, GLU505J, GLU534I, GLU534J, GLU55I, GLU55J, GLU92I, GLU92J, GLY115I, GLY115J, GLY124I, GLY124J, GLY176J, GLY314I, GLY314J, GLY31I, GLY31J, GLY414I, GLY414J, GLY417I, GLY417J, GLY420I, GLY420J, GLY471I, GLY471J, GLY472I, GLY472J, GLY57I, GLY57J, GLY80I, GLY80J, GLY94I, GLY94J, HIS129I, HIS129J, HIS320I, HIS320J, HIS496I, HIS496J, HIS499I, HIS499J, HIS49I, HIS49J, HIS50I, HIS50J, HIS52I, HIS52J, HIS60I, HIS60J, ILE112I, ILE112J, ILE120I, ILE120J, ILE26I, ILE26J, ILE28I, ILE28J, ILE308I, ILE308J, ILE312I, ILE418I, ILE418J, ILE474I, ILE474J, ILE48I, ILE48J, ILE76I, ILE76J, ILE91I, ILE91J, LEU111I, LEU111J, LEU174I, LEU174J, LEU253I, LEU253J, LEU289I, LEU289J, LEU295I, LEU295J, LEU316I, LEU316J, LEU36I, LEU36J, LEU37I, LEU37J, LEU39I, LEU39J, LEU443I, LEU443J, LEU446I, LEU446J, LEU449I, LEU449J, LEU452I, LEU452J, LEU454I, LEU454J, LEU478I, LEU478J, LEU490I, LEU490J, LEU58I, LEU58J, LEU63I, LEU63J, LEU86I, LEU86J, LEU90I, LEU90J, LEU95I, LEU95J, LYS292I, LYS292J, MET125I, MET125J, MET178J, MET491I, MET491J, MET503I, MET503J, PHE126I, PHE126J, PHE475I, PHE475J, PHE47I, PHE47J, PHE488I, PHE488J, PHE497I, PHE497J, PHE504I, PHE504J, PHE53I, PHE53J, PRO108I, PRO108J, PRO109I, PRO109J, PRO123I, PRO123J, PRO130J, PRO30I, PRO30J, PRO318I, PRO318J, PRO479I, PRO479J, PRO481I, PRO481J, PRO492I, PRO492J, PRO88I, PRO88J, SER128I, SER128J, SER287I, SER287J, SER288I, SER288J, SER32I, SER32J, SER34I, SER34J, SER416I, SER416J, SER444I, SER444J, SER483I, SER483J, SER79I, SER79J, THR131J, THR290I, THR290J, THR35I, THR35J, THR38I, THR38J, THR480I, THR480J, THR51I, THR51J, THR78I, THR78J, THR81I, THR81J, TYR175I, TYR175J, TYR447I, TYR447J, TYR489I, TYR489J, TYR87I, TYR87J, VAL394I, VAL394J, VAL466I, VAL466J, VAL495I, VAL495J, VAL77I, VAL77J, VAL83I, VAL83J
• I-S: ALA520S, ALA522S, ALA524S, ARG212I, ARG218I, ARG322I, ARG324I, ARG526S, ASP213I, ASP523S, GLN211I, GLN219I, GLN280I, GLN383S, GLN515S, GLU209I, GLU304I, GLU305I, GLU340I, GLU382S, GLU516S, GLU518S, HIS509S, LEU380S, LEU517S, LYS220I, LYS507S, PHE215I, PHE216I, PHE521S, PRO381S, PRO435S, PRO461S, THR519S, THR527S, TRP214I, TRP217I, TRP307I, TRP514S, TRP525S
• R-S: ALA116R, ALA116S, ALA119R, ALA119S, ALA127R, ALA127S, ALA299R, ALA299S, ALA29R, ALA29S, ALA319R, ALA319S, ALA40R, ALA40S, ALA415R, ALA415S, ALA41R, ALA41S, ALA42R, ALA42S, ALA445R, ALA445S, ALA451R, ALA451S, ALA453R, ALA453S, ALA500R, ALA500S, ALA501R, ALA501S, ALA502R, ALA502S, ALA82R, ALA82S, ALA84R, ALA84S, ALA89R, ALA89S, ALA93R, ALA93S, ARG107R, ARG107S, ARG121R, ARG121S, ARG228R, ARG228S, ARG315R, ARG315S, ARG325R, ARG325S, ARG33R, ARG33S, ARG395R, ARG395S, ARG413R, ARG413S, ARG430R, ARG430S, ARG456R, ARG456S, ARG485R, ARG485S, ARG487R, ARG487S, ARG56R, ARG56S, ARG8R, ARG8S, ASN117R, ASN117S, ASN390R, ASN390S, ASN412R, ASN412S, ASN44S, ASN450R, ASN450S, ASN468R, ASN468S, ASN470S, ASN494R, ASN494S, ASN85R, ASN85S, ASP113R, ASP113S, ASP317R, ASP317S, ASP419R, ASP419S, ASP442R, ASP442S, ASP448R, ASP448S, ASP54R, ASP54S, CYS114R, CYS114S, CYS27R, CYS27S, GLN118R, GLN118S, GLN122R, GLN122S, GLN284R, GLN284S, GLN457R, GLN457S, GLN482R, GLN482S, GLN493R, GLN493S, GLU110R, GLU110S, GLU172S, GLU313R, GLU313S, GLU43R, GLU43S, GLU484R, GLU484S, GLU486R, GLU486S, GLU498R, GLU498S, GLU505R, GLU505S, GLU534R, GLU534S, GLU55R, GLU55S, GLU92R, GLU92S, GLY115R, GLY115S, GLY124R, GLY124S, GLY176S, GLY314R, GLY314S, GLY31R, GLY31S, GLY414R, GLY414S, GLY417R, GLY417S, GLY420R, GLY420S, GLY471R, GLY471S, GLY472R, GLY472S, GLY57R, GLY57S, GLY59R, GLY80R, GLY80S, GLY94R, GLY94S, HIS129R, HIS129S, HIS320R, HIS320S, HIS496R, HIS496S, HIS499R, HIS499S, HIS49R, HIS49S, HIS50R, HIS50S, HIS52R, HIS52S, HIS60R, HIS60S, ILE112R, ILE112S, ILE120R, ILE120S, ILE26R, ILE26S, ILE28R, ILE28S, ILE308R, ILE308S, ILE312R, ILE312S, ILE418R, ILE418S, ILE474R, ILE474S, ILE48R, ILE48S, ILE76R, ILE76S, ILE91R, ILE91S, LEU111R, LEU111S, LEU174R, LEU174S, LEU253R, LEU253S, LEU289R, LEU289S, LEU295R, LEU295S, LEU316R, LEU316S, LEU36R, LEU36S, LEU37R, LEU37S, LEU39R, LEU39S, LEU443R, LEU443S, LEU446R, LEU446S, LEU449R, LEU449S, LEU452R, LEU452S, LEU454R, LEU454S, LEU478R, LEU478S, LEU490R, LEU490S, LEU58R, LEU58S, LEU63R, LEU63S, LEU86R, LEU86S, LEU90R, LEU90S, LEU95R, LEU95S, LYS292R, LYS292S, MET125R, MET125S, MET491R, MET491S, MET503R, MET503S, PHE126R, PHE126S, PHE475R, PHE475S, PHE47R, PHE47S, PHE488R, PHE488S, PHE497R, PHE497S, PHE504R, PHE504S, PHE53R, PHE53S, PRO108S, PRO109R, PRO109S, PRO123R, PRO123S, PRO130S, PRO30R, PRO30S, PRO318R, PRO318S, PRO479R, PRO479S, PRO481R, PRO481S, PRO492R, PRO492S, PRO88R, PRO88S, SER128R, SER128S, SER287R, SER287S, SER288R, SER288S, SER32R, SER32S, SER34R, SER34S, SER416R, SER416S, SER444R, SER444S, SER483R, SER483S, SER79R, SER79S, THR131R, THR131S, THR290R, THR290S, THR35R, THR35S, THR38R, THR38S, THR480R, THR480S, THR51R, THR51S, THR78R, THR78S, THR81R, THR81S, THR96S, TYR175R, TYR175S, TYR447R, TYR447S, TYR489R, TYR489S, TYR87R, TYR87S, VAL394R, VAL394S, VAL466R, VAL466S, VAL495R, VAL495S, VAL77S, VAL83R, VAL83S
• R-Z: ALA145R, ALA145Z, ALA155R, ALA155Z, ALA203R, ALA203Z, ALA299R, ALA299Z, ALA319R, ALA319Z, ALA328R, ALA328Z, ARG146R, ARG146Z, ARG188R, ARG188Z, ARG201R, ARG201Z, ARG205R, ARG205Z, ARG20R, ARG20Z, ARG212R, ARG212Z, ARG315R, ARG315Z, ARG322R, ARG322Z, ARG324R, ARG324Z, ARG325R, ARG325Z, ASP153R, ASP153Z, ASP191R, ASP191Z, ASP195R, ASP195Z, ASP196R, ASP196Z, ASP213R, ASP213Z, ASP317R, ASP317Z, GLN194R, GLN194Z, GLN211R, GLN211Z, GLN298R, GLU202R, GLU202Z, GLU207R, GLU207Z, GLU209R, GLU209Z, GLU302R, GLU302Z, GLU304R, GLU304Z, GLU305R, GLU305Z, GLU313R, GLU313Z, GLY190R, GLY190Z, GLY314R, GLY314Z, GLY323R, GLY323Z, HIS132R, HIS132Z, HIS154R, HIS154Z, HIS160R, HIS160Z, HIS320R, HIS320Z, HIS321R, HIS321Z, ILE134R, ILE134Z, ILE143R, ILE143Z, ILE152R, ILE152Z, ILE281R, ILE281Z, ILE308R, ILE308Z, ILE312R, ILE312Z, ILE327R, ILE327Z, LEU148R, LEU148Z, LEU189R, LEU189Z, LEU200R, LEU200Z, LEU206R, LEU206Z, LEU316R, LEU316Z, LEU326R, LEU326Z, LYS197R, LYS197Z, LYS210R, LYS210Z, PRO144R, PRO144Z, PRO198R, PRO198Z, PRO204R, PRO204Z, PRO318R, PRO318Z, SER150R, SER150Z, SER208R, SER208Z, SER300R, SER300Z, THR151R, THR151Z, THR158R, THR158Z, TRP147R, TRP147Z, TRP192R, TRP192Z, TRP193R, TRP193Z, TRP199R, TRP199Z, TRP217R, TRP217Z, TRP307R, TRP307Z, TYR306R, TYR306Z, VAL149R, VAL149Z
• R-1: ALA1711, ALA171R, ARG1211, ARG121R, ARG1381, ARG138R, ARG1461, ARG146R, ASP1131, ASP113R, ASP1421, ASP142R, CYS1141, CYS114R, GLN1411, GLN141R, GLU1101, GLU110R, GLU1721, HIS132R, HIS1541, HIS154R, ILE1121, ILE112R, ILE134R, ILE1431, ILE143R, LEU1111, LEU111R, LEU1361, LEU136R, LEU1481, LEU148R, LEU2001, LEU200R, MET11, MET1R, PRO1081, PRO108R, PRO1091, PRO109R, PRO1231, PRO1371, PRO137R, PRO1391, PRO139R, PRO1441, PRO144R, PRO1731, SER1331, SER133R, SER1351, SER135R, SER1501, SER150R, THR1401, THR140R, THR1511, THR151R, TRP101, TRP10R, TRP1471, TRP147R, VAL31, VAL3R
• S-Z: ALA171S, ALA171Z, ARG121S, ARG121Z, ARG138S, ARG138Z, ARG146S, ARG146Z, ASP113S, ASP113Z, ASP142S, ASP142Z, CYS114S, CYS114Z, GLN141S, GLN141Z, GLU110S, GLU110Z, HIS132Z, HIS154S, HIS154Z, ILE112S, ILE112Z, ILE134Z, ILE143S, ILE143Z, LEU111S, LEU111Z, LEU136S, LEU136Z, LEU148S, LEU148Z, LEU200S, MET1Z, PRO108S, PRO108Z, PRO109S, PRO109Z, PRO123Z, PRO137S, PRO137Z, PRO139S, PRO139Z, PRO144S, PRO144Z, SER133S, SER133Z, SER135S, SER135Z, SER150S, SER150Z, THR140S, THR140Z, THR151S, THR151Z, TRP10S, TRP10Z, TRP147S, TRP147Z, VAL3S, VAL3Z
• S-1: ALA1451, ALA145S, ALA1551, ALA155S, ALA2031, ALA203S, ALA2991, ALA299S, ALA3191, ALA319S, ALA3281, ALA328S, ARG1461, ARG146S, ARG1881, ARG188S, ARG201, ARG2011, ARG201S, ARG2051, ARG205S, ARG20S, ARG2121, ARG212S, ARG3151, ARG315S, ARG3221, ARG322S, ARG3241, ARG324S, ARG3251, ARG325S, ASP1531, ASP153S, ASP1911, ASP191S, ASP1951, ASP195S, ASP1961, ASP196S, ASP2131, ASP213S, ASP3171, ASP317S, CYS301S, GLN1941, GLN194S, GLN2111, GLN211S, GLN298S, GLU2021, GLU202S, GLU2071, GLU207S, GLU2091, GLU209S, GLU3021, GLU302S, GLU3041, GLU304S, GLU3051, GLU305S, GLU3131, GLU313S, GLY1571, GLY157S, GLY1901, GLY190S, GLY3141, GLY314S, GLY3231, GLY323S, HIS1321, HIS132S, HIS1541, HIS154S, HIS1601, HIS160S, HIS3201, HIS320S, HIS3211, HIS321S, ILE1341, ILE1431, ILE143S, ILE1521, ILE152S, ILE3081, ILE308S, ILE3121, ILE312S, ILE3271, ILE327S, LEU1481, LEU148S, LEU1891, LEU189S, LEU2001, LEU200S, LEU2061, LEU206S, LEU3161, LEU316S, LEU3261, LEU326S, LYS1971, LYS197S, LYS2101, PRO1441, PRO144S, PRO1981, PRO198S, PRO2041, PRO204S, PRO3181, PRO318S, SER1501, SER150S, SER2081, SER208S, SER3001, SER300S, THR1511, THR151S, THR1581, THR158S, TRP1471, TRP147S, TRP1921, TRP192S, TRP1931, TRP193S, TRP1991, TRP199S, TRP2171, TRP217S, TRP3071, TRP307S, TYR3061, TYR306S, VAL1491, VAL149S
• Z-1: ALA1161, ALA116Z, ALA1191, ALA119Z, ALA1271, ALA127Z, ALA291, ALA2991, ALA29Z, ALA3191, ALA319Z, ALA401, ALA40Z, ALA411, ALA4151, ALA415Z, ALA41Z, ALA421, ALA42Z, ALA4451, ALA445Z, ALA4511, ALA451Z, ALA4531, ALA453Z, ALA5001, ALA500Z, ALA5011, ALA501Z, ALA5021, ALA502Z, ALA821, ALA82Z, ALA841, ALA84Z, ALA891, ALA89Z, ALA931, ALA93Z, ARG1071, ARG107Z, ARG1211, ARG121Z, ARG2281, ARG228Z, ARG3151, ARG315Z, ARG3251, ARG325Z, ARG331, ARG33Z, ARG3951, ARG395Z, ARG4131, ARG413Z, ARG4301, ARG430Z, ARG4561, ARG456Z, ARG4851, ARG485Z, ARG4871, ARG487Z, ARG561, ARG56Z, ARG81, ARG8Z, ASN1171, ASN117Z, ASN3901, ASN390Z, ASN4121, ASN412Z, ASN4501, ASN450Z, ASN4681, ASN468Z, ASN4701, ASN4941, ASN494Z, ASN851, ASN85Z, ASP1131, ASP113Z, ASP3171, ASP317Z, ASP4191, ASP419Z, ASP4421, ASP442Z, ASP4481, ASP448Z, ASP541, ASP54Z, CYS1141, CYS114Z, CYS271, CYS27Z, GLN1181, GLN118Z, GLN1221, GLN122Z, GLN2841, GLN284Z, GLN298Z, GLN4571, GLN457Z, GLN4821, GLN482Z, GLN4931, GLN493Z, GLU1101, GLU110Z, GLU1721, GLU3131, GLU313Z, GLU431, GLU43Z, GLU4841, GLU484Z, GLU4861, GLU486Z, GLU4981, GLU498Z, GLU5051, GLU505Z, GLU5341, GLU534Z, GLU551, GLU55Z, GLU921, GLU92Z, GLY1151, GLY115Z, GLY1241, GLY124Z, GLY1761, GLY311, GLY3141, GLY314Z, GLY31Z, GLY4141, GLY414Z, GLY4171, GLY417Z, GLY4201, GLY420Z, GLY4711, GLY471Z, GLY4721, GLY472Z, GLY571, GLY57Z, GLY591, GLY801, GLY80Z, GLY941, GLY94Z, HIS1291, HIS129Z, HIS3201, HIS320Z, HIS491, HIS4961, HIS496Z, HIS4991, HIS499Z, HIS49Z, HIS501, HIS50Z, HIS521, HIS52Z, HIS601, HIS60Z, ILE1121, ILE112Z, ILE1201, ILE120Z, ILE261, ILE26Z, ILE281, ILE28Z, ILE3081, ILE308Z, ILE3121, ILE312Z, ILE4181, ILE418Z, ILE4741, ILE474Z, ILE481, ILE48Z, ILE761, ILE76Z, ILE911, ILE91Z, LEU1111, LEU111Z, LEU1741, LEU174Z, LEU2531, LEU253Z, LEU2891, LEU289Z, LEU2951, LEU295Z, LEU3161, LEU316Z, LEU361, LEU36Z, LEU371, LEU37Z, LEU391, LEU39Z, LEU4431, LEU443Z, LEU4461, LEU446Z, LEU4491, LEU449Z, LEU4521, LEU452Z, LEU4541, LEU454Z, LEU4781, LEU478Z, LEU4901, LEU490Z, LEU581, LEU58Z, LEU631, LEU63Z, LEU861, LEU86Z, LEU901, LEU90Z, LEU951, LEU95Z, LYS292Z, MET1251, MET125Z, MET1781, MET4911, MET491Z, MET5031, MET503Z, PHE1261, PHE126Z, PHE471, PHE4751, PHE475Z, PHE47Z, PHE4881, PHE488Z, PHE4971, PHE497Z, PHE5041, PHE504Z, PHE531, PHE53Z, PRO1081, PRO1091, PRO109Z, PRO1231, PRO123Z, PRO1301, PRO130Z, PRO301, PRO30Z, PRO3181, PRO318Z, PRO4791, PRO479Z, PRO4811, PRO481Z, PRO4921, PRO492Z, PRO881, PRO88Z, SER1281, SER128Z, SER2871, SER287Z, SER2881, SER288Z, SER321, SER32Z, SER341, SER34Z, SER3911, SER4161, SER416Z, SER4441, SER444Z, SER4831, SER483Z, SER791, SER79Z, THR1311, THR2901, THR290Z, THR351, THR35Z, THR381, THR38Z, THR4801, THR480Z, THR511, THR51Z, THR781, THR78Z, THR811, THR81Z, THR961, TYR1751, TYR175Z, TYR4471, TYR447Z, TYR4891, TYR489Z, TYR871, TYR87Z, VAL3941, VAL394Z, VAL4661, VAL466Z, VAL4951, VAL495Z, VAL771, VAL77Z, VAL831, VAL83Z