3HWK

crystal structure of methylcitrate synthase from mycobacterium tuberculosis

• Total interactions analyzed: 28
• Total true interactions: 19
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 308
  • Norm. En. per Res.: -5.5281
• Hub Node: B(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-336.0491	31.0997	-1369.09	-1674.0395	309	49	44	51446	26	87	84
A-D	-2.601	0.0	-32.7768	-35.3778	16	0	0	1193	0	1	0
A-G	-24.1386	-34.502	-54.0566	-112.6972	27	2	0	1815	3	7	10
A-H	-88.8849	-94.6455	-246.2	-429.7304	93	19	3	8435	9	48	51
B-C	0.0	8.9665	-7.571	1.3955	14	0	0	380	0	7	4
B-D	-14.1337	24.9507	-97.4145	-86.5975	89	6	3	5654	0	34	36
B-F	0.0	0.0	-1.1923	-1.1923	12	0	0	123	0	6	0
B-G	-22.2329	-8.7649	-35.7047	-66.7024	29	1	1	1500	0	5	13
B-H	-19.193	-35.9531	-46.9413	-102.0873	26	1	0	1732	3	7	11
C-D	-340.9372	5.0162	-1342.86	-1678.781	304	49	43	50988	24	86	84
C-E	-77.4466	-62.2313	-253.255	-392.9329	91	15	3	8396	8	48	51
C-F	-22.5033	-37.7133	-44.6068	-104.8234	27	2	0	1672	3	7	10
D-E	-22.3579	-33.3828	-52.1756	-107.9163	27	2	0	1757	3	7	10
D-F	-15.3738	-10.6359	-27.4318	-53.4415	30	1	1	1537	0	6	13
E-F	-373.5675	1.5312	-1330.63	-1702.6662	308	51	43	51012	28	88	84
E-G	-5.255	0.0	-34.0099	-39.2649	19	0	1	1304	0	1	0
F-G	-17.8791	-29.8037	-106.474	-154.1568	92	8	2	5894	3	34	34
F-H	0.0	9.4207	-6.5968	2.8239	14	0	0	321	0	7	3
G-H	-330.7395	9.9076	-1328.76	-1649.5919	304	47	44	50469	27	88	84

Interface residues

• A-B: ALA108A, ALA123A, ALA123B, ALA129A, ALA129B, ALA211A, ALA211B, ALA215A, ALA215B, ALA216A, ALA216B, ALA229A, ALA229B, ALA233A, ALA233B, ALA236A, ALA236B, ALA245A, ALA245B, ALA33A, ALA33B, ALA371A, ALA371B, ALA373A, ALA373B, ALA380A, ALA380B, ALA41A, ALA41B, ALA63A, ALA63B, ALA64A, ALA64B, ARG101A, ARG101B, ARG121A, ARG121B, ARG161A, ARG161B, ARG162A, ARG162B, ARG217A, ARG217B, ARG240A, ARG240B, ARG282A, ARG282B, ARG285A, ARG285B, ARG290A, ARG290B, ARG357A, ARG357B, ARG376A, ARG376B, ARG387A, ARG387B, ARG55A, ARG55B, ARG65A, ARG65B, ARG77A, ARG77B, ASN113A, ASN113B, ASN210A, ASN210B, ASN372A, ASN372B, ASN50B, ASP100A, ASP118A, ASP118B, ASP131A, ASP131B, ASP135A, ASP135B, ASP225A, ASP225B, ASP27A, ASP27B, ASP38A, ASP38B, ASP61A, ASP61B, CYS114A, CYS114B, CYS382A, CYS382B, CYS66A, CYS66B, GLN223A, GLN223B, GLN368A, GLN368B, GLN386A, GLN386B, GLN48B, GLN60A, GLN60B, GLN70A, GLN70B, GLU130A, GLU130B, GLU134A, GLU134B, GLU206A, GLU206B, GLU367A, GLU367B, GLU385A, GLU385B, GLU79A, GLU79B, GLY128A, GLY128B, GLY208A, GLY208B, GLY232A, GLY232B, GLY235A, GLY235B, GLY239A, GLY239B, GLY243A, GLY243B, GLY244A, GLY244B, GLY280A, GLY280B, GLY31A, GLY31B, GLY34A, GLY34B, GLY383A, GLY383B, GLY391A, GLY56A, GLY56B, GLY78A, GLY78B, HIS115A, HIS115B, HIS207A, HIS207B, HIS242A, HIS242B, HIS281A, HIS281B, HIS364A, HIS364B, HIS384A, HIS384B, ILE124A, ILE124B, ILE226A, ILE226B, ILE234A, ILE234B, ILE28A, ILE28B, ILE375A, ILE375B, ILE42A, ILE42B, LEU106A, LEU106B, LEU107A, LEU110A, LEU110B, LEU127A, LEU127B, LEU237A, LEU237B, LEU241A, LEU241B, LEU32A, LEU32B, LEU374A, LEU374B, LEU378A, LEU378B, LEU389A, LEU389B, LEU52A, LEU52B, LEU62A, LEU62B, LEU74A, LEU74B, LEU80A, LEU80B, LYS109A, LYS109B, LYS238A, LYS238B, LYS275A, LYS275B, LYS29A, LYS29B, LYS30A, LYS30B, LYS44A, LYS44B, MET103A, MET117A, MET117B, MET147A, MET277A, MET277B, PHE209A, PHE209B, PHE214A, PHE214B, PRO111A, PRO111B, PRO132A, PRO132B, PRO377A, PRO377B, PRO390A, PRO390B, PRO47A, PRO47B, PRO58A, PRO58B, PRO81A, PRO81B, SER102A, SER102B, SER105A, SER105B, SER125A, SER125B, SER212A, SER212B, SER221A, SER221B, SER224A, SER224B, SER228A, SER228B, SER379A, SER379B, SER43A, SER43B, SER51A, SER51B, THR122A, THR122B, THR213A, THR213B, THR220A, THR220B, THR222A, THR222B, THR231A, THR231B, THR370A, THR370B, THR392A, THR39A, THR39B, THR40A, THR40B, THR49A, THR49B, THR53A, THR53B, TYR126A, TYR126B, TYR227A, TYR227B, TYR284A, TYR284B, TYR381A, TYR381B, TYR54A, TYR54B, TYR57A, TYR57B, VAL119A, VAL119B, VAL120A, VAL120B, VAL218A, VAL218B, VAL219A, VAL219B, VAL230A, VAL230B, VAL283A, VAL283B, VAL35A, VAL35B, VAL36A, VAL36B, VAL37A, VAL37B, VAL388A, VAL388B, VAL45A, VAL45B, VAL46A, VAL46B, VAL59A, VAL59B, VAL71A, VAL71B
• A-D: ALA84D, ALA87D, ARG77D, ASP83D, GLU85D, GLY391A, LEU389A, LEU86D, LEU88D, PHE73D, PHE89D, PRO390A, PRO81D, THR392A, THR82D, VAL388A
• A-G: ALA108A, ARG101A, ARG121G, ARG161G, ARG162G, ASN113G, ASP100A, ASP112G, ASP118G, CYS114G, GLU130A, GLY164G, HIS115G, LEU104A, LEU106A, LEU107A, LEU110G, LYS109A, LYS109G, LYS238G, MET103A, PRO111G, PRO167A, SER102A, SER105A, TYR126A, VAL119G
• A-H: ALA129A, ALA129H, ALA139A, ALA139H, ALA142A, ALA142H, ALA169A, ALA169H, ALA84A, ALA84H, ALA87A, ALA87H, ALA95A, ALA95H, ARG101A, ARG101H, ARG146A, ARG146H, ARG77A, ARG92A, ARG92H, ARG94A, ARG94H, ARG97A, ARG98A, ARG98H, ASP100A, ASP100H, ASP131A, ASP131H, ASP133A, ASP133H, ASP135A, ASP135H, ASP136A, ASP136H, ASP83A, ASP83H, GLN91A, GLN91H, GLU130A, GLU130H, GLU134A, GLU134H, GLU85A, GLU85H, GLU93A, GLU93H, GLY128A, GLY128H, ILE157A, ILE157H, LEU104A, LEU104H, LEU127A, LEU127H, LEU86A, LEU86H, LEU88A, LEU88H, LYS143A, LYS143H, MET103A, MET103H, MET145A, MET145H, PHE89A, PHE89H, PRO132A, PRO132H, PRO167A, PRO167H, PRO170A, PRO170H, SER102A, SER102H, SER105A, SER105H, SER125H, SER172A, SER172H, SER90A, SER90H, SER96A, SER96H, THR153A, THR153H, TYR126A, TYR126H, TYR227A, TYR227H, VAL99A, VAL99H
• B-C: ARG300B, ARG305B, ASN113C, ASP112C, ASP306B, CYS114C, GLN308B, GLU299B, GLY302B, GLY307B, LEU311B, PRO111C, THR303B, VAL304B
• B-D: ALA129D, ALA142D, ALA169D, ALA177B, ALA192B, ALA63B, ALA64B, ALA84B, ALA84D, ALA87B, ALA87D, ALA95D, ARG101D, ARG146D, ARG296B, ARG300B, ARG65B, ARG77D, ARG92D, ARG94B, ARG94D, ARG97B, ARG97D, ARG98D, ASP100D, ASP131D, ASP133D, ASP61B, ASP83B, ASP83D, CYS66B, GLN178B, GLN199B, GLN70B, GLN91D, GLU130D, GLU134D, GLU187B, GLU190B, GLU198B, GLU299B, GLU69B, GLU85D, GLY173B, GLY173D, GLY175B, GLY302B, HIS171B, HIS171D, HIS182B, ILE202B, LEU104D, LEU127D, LEU174B, LEU62B, LEU74B, LEU80B, LEU86B, LEU86D, LEU88D, MET103D, MET145D, PHE68B, PHE73D, PHE89D, PRO132D, PRO170D, PRO189B, PRO81B, SER102D, SER172B, SER172D, SER195B, SER67B, SER90B, SER90D, SER96D, THR191B, THR303B, THR82B, TYR57B, VAL150D, VAL188B, VAL193B, VAL194B, VAL301B, VAL304B, VAL71B, VAL99D
• B-F: GLU187B, GLU187F, GLY164B, GLY164F, GLY186B, GLY186F, LEU165B, LEU165F, PHE185B, PHE185F, PRO166B, PRO166F
• B-G: ALA108B, ALA108G, ARG101B, ARG101G, ARG161B, ARG161G, ARG162B, ASN113B, ASN113G, ASP112B, ASP112G, GLY164B, GLY164G, LEU104B, LEU104G, LEU106B, LEU106G, LEU107B, LEU107G, LEU110B, LEU110G, LEU165G, LYS109B, LYS109G, PRO111B, PRO111G, PRO166G, SER105B, SER105G
• B-H: ALA108H, ARG101H, ARG121B, ARG161B, ARG162B, ASN113B, ASP100H, ASP112B, ASP118B, CYS114B, GLU130H, GLY164B, HIS115B, LEU104H, LEU106H, LEU107H, LEU110B, LYS109B, LYS109H, LYS238B, MET103H, PRO111B, PRO167H, SER102H, SER105H, TYR126H
• C-D: ALA108D, ALA123C, ALA123D, ALA129C, ALA129D, ALA137D, ALA211C, ALA211D, ALA215C, ALA215D, ALA216C, ALA216D, ALA229C, ALA229D, ALA233C, ALA233D, ALA236C, ALA236D, ALA245D, ALA33C, ALA33D, ALA371C, ALA371D, ALA373C, ALA373D, ALA380C, ALA380D, ALA41C, ALA41D, ALA63C, ALA63D, ALA64C, ALA64D, ARG101D, ARG121C, ARG121D, ARG161C, ARG161D, ARG162C, ARG162D, ARG217C, ARG217D, ARG240C, ARG240D, ARG282C, ARG282D, ARG285D, ARG290C, ARG290D, ARG357C, ARG357D, ARG376C, ARG376D, ARG387C, ARG387D, ARG55C, ARG55D, ARG65C, ARG65D, ARG77C, ARG77D, ASN113C, ASN113D, ASN210C, ASN210D, ASN372C, ASN372D, ASN50C, ASP112D, ASP118C, ASP118D, ASP131C, ASP131D, ASP135C, ASP135D, ASP136D, ASP225C, ASP225D, ASP27C, ASP27D, ASP38C, ASP38D, ASP61C, ASP61D, CYS114C, CYS114D, CYS382C, CYS382D, CYS66C, CYS66D, GLN223C, GLN223D, GLN368C, GLN368D, GLN386C, GLN386D, GLN48C, GLN48D, GLN60C, GLN60D, GLN70C, GLN70D, GLU130C, GLU130D, GLU134C, GLU134D, GLU206C, GLU206D, GLU367C, GLU367D, GLU385C, GLU385D, GLU79C, GLU79D, GLY128C, GLY128D, GLY208C, GLY208D, GLY232C, GLY232D, GLY235C, GLY235D, GLY239C, GLY239D, GLY243C, GLY243D, GLY244C, GLY244D, GLY280D, GLY31C, GLY31D, GLY34C, GLY34D, GLY383C, GLY383D, GLY391D, GLY56C, GLY56D, GLY78C, GLY78D, HIS115C, HIS115D, HIS207C, HIS207D, HIS242C, HIS242D, HIS281C, HIS281D, HIS364C, HIS364D, HIS384C, HIS384D, ILE124C, ILE124D, ILE226C, ILE226D, ILE234C, ILE234D, ILE28C, ILE28D, ILE375C, ILE375D, ILE42C, ILE42D, LEU106C, LEU106D, LEU107C, LEU107D, LEU110C, LEU110D, LEU127C, LEU127D, LEU237C, LEU237D, LEU241C, LEU241D, LEU32C, LEU32D, LEU374C, LEU374D, LEU378C, LEU378D, LEU389C, LEU389D, LEU52C, LEU52D, LEU62C, LEU62D, LEU74C, LEU74D, LEU80C, LEU80D, LYS109C, LYS109D, LYS238C, LYS238D, LYS275C, LYS275D, LYS29C, LYS29D, LYS30C, LYS30D, LYS44C, LYS44D, MET117C, MET117D, MET277D, PHE209C, PHE209D, PHE214C, PHE214D, PRO111C, PRO111D, PRO132C, PRO132D, PRO377C, PRO377D, PRO390C, PRO390D, PRO47C, PRO58C, PRO58D, PRO81C, PRO81D, SER102C, SER102D, SER105C, SER105D, SER125C, SER125D, SER212C, SER212D, SER221C, SER221D, SER224C, SER224D, SER228C, SER228D, SER379C, SER379D, SER43C, SER43D, SER51C, SER51D, THR122C, THR122D, THR213C, THR213D, THR220C, THR220D, THR222C, THR222D, THR231C, THR231D, THR370C, THR370D, THR39C, THR39D, THR40C, THR40D, THR49C, THR49D, THR53C, THR53D, TYR126C, TYR126D, TYR227C, TYR227D, TYR284C, TYR284D, TYR381C, TYR381D, TYR54C, TYR54D, TYR57C, TYR57D, VAL119C, VAL119D, VAL120C, VAL120D, VAL218C, VAL218D, VAL219C, VAL219D, VAL230C, VAL230D, VAL283C, VAL283D, VAL35C, VAL35D, VAL36C, VAL36D, VAL37C, VAL37D, VAL388C, VAL388D, VAL45C, VAL45D, VAL46C, VAL46D, VAL59C, VAL59D, VAL71C, VAL71D
• C-E: ALA129C, ALA129E, ALA139C, ALA139E, ALA142C, ALA142E, ALA169C, ALA169E, ALA84C, ALA84E, ALA87C, ALA87E, ALA95C, ALA95E, ARG101C, ARG101E, ARG146C, ARG146E, ARG92C, ARG92E, ARG94C, ARG94E, ARG97C, ARG98C, ARG98E, ASP100C, ASP100E, ASP131C, ASP131E, ASP133C, ASP133E, ASP135C, ASP135E, ASP136C, ASP136E, ASP83C, ASP83E, GLN91C, GLN91E, GLU130C, GLU130E, GLU134C, GLU134E, GLU85C, GLU85E, GLU93C, GLU93E, GLY128C, GLY128E, ILE157C, ILE157E, LEU104C, LEU104E, LEU127C, LEU127E, LEU86C, LEU86E, LEU88C, LEU88E, LYS143C, LYS143E, MET103C, MET103E, MET145C, MET145E, PHE89C, PHE89E, PRO132C, PRO132E, PRO167C, PRO167E, PRO170C, PRO170E, SER102C, SER102E, SER105C, SER105E, SER172C, SER172E, SER90C, SER90E, SER96C, SER96E, THR153C, THR153E, TYR126C, TYR126E, TYR227C, TYR227E, VAL99C, VAL99E
• C-F: ALA108C, ARG101C, ARG121F, ARG161F, ARG162F, ASN113F, ASP100C, ASP112F, ASP118F, CYS114F, GLU130C, GLY164F, HIS115F, LEU104C, LEU106C, LEU107C, LEU110F, LYS109C, LYS109F, LYS238F, MET103C, PRO111F, PRO167C, SER102C, SER105C, TYR126C, VAL119F
• D-E: ALA108E, ARG101E, ARG121D, ARG161D, ARG162D, ASN113D, ASP100E, ASP112D, ASP118D, CYS114D, GLU130E, GLY164D, HIS115D, LEU104E, LEU106E, LEU107E, LEU110D, LYS109D, LYS109E, LYS238D, MET103E, PRO111D, PRO116D, PRO167E, SER102E, SER105E, TYR126E
• D-F: ALA108D, ALA108F, ARG101D, ARG101F, ARG161D, ARG161F, ARG162D, ARG162F, ASN113D, ASN113F, ASP112D, ASP112F, GLY164D, GLY164F, LEU104D, LEU104F, LEU106D, LEU106F, LEU107D, LEU107F, LEU110D, LEU110F, LEU165D, LYS109D, LYS109F, PRO111D, PRO111F, PRO166D, SER105D, SER105F
• E-F: ALA123E, ALA123F, ALA129E, ALA129F, ALA211E, ALA211F, ALA215E, ALA215F, ALA216E, ALA216F, ALA229E, ALA229F, ALA233E, ALA233F, ALA236E, ALA236F, ALA245F, ALA33E, ALA33F, ALA371E, ALA371F, ALA373E, ALA373F, ALA380E, ALA380F, ALA41E, ALA41F, ALA63E, ALA63F, ALA64E, ALA64F, ARG101F, ARG121E, ARG121F, ARG161E, ARG161F, ARG162E, ARG162F, ARG217E, ARG217F, ARG240E, ARG240F, ARG282E, ARG282F, ARG285E, ARG285F, ARG290E, ARG290F, ARG357E, ARG357F, ARG376E, ARG376F, ARG387E, ARG387F, ARG55E, ARG55F, ARG65E, ARG65F, ARG77E, ARG77F, ASN113E, ASN113F, ASN210E, ASN210F, ASN372E, ASN372F, ASP118E, ASP118F, ASP131E, ASP131F, ASP135E, ASP135F, ASP225E, ASP225F, ASP27E, ASP27F, ASP38E, ASP38F, ASP61E, ASP61F, CYS114E, CYS114F, CYS382E, CYS382F, CYS66E, CYS66F, GLN223E, GLN223F, GLN368E, GLN368F, GLN386E, GLN386F, GLN48E, GLN48F, GLN60E, GLN60F, GLN70E, GLN70F, GLU130E, GLU130F, GLU134E, GLU134F, GLU206E, GLU206F, GLU367E, GLU367F, GLU385E, GLU385F, GLU79E, GLU79F, GLY128E, GLY128F, GLY208E, GLY208F, GLY232E, GLY232F, GLY235E, GLY235F, GLY239E, GLY239F, GLY243E, GLY243F, GLY244E, GLY244F, GLY280E, GLY280F, GLY31E, GLY31F, GLY34E, GLY34F, GLY383E, GLY383F, GLY391E, GLY391F, GLY56E, GLY56F, GLY78E, GLY78F, HIS115E, HIS115F, HIS207E, HIS207F, HIS242E, HIS242F, HIS281E, HIS281F, HIS364E, HIS364F, HIS384E, HIS384F, ILE124E, ILE124F, ILE202F, ILE226E, ILE226F, ILE234E, ILE234F, ILE28E, ILE28F, ILE375E, ILE375F, ILE42E, ILE42F, LEU106E, LEU106F, LEU107E, LEU107F, LEU110E, LEU110F, LEU127E, LEU127F, LEU237E, LEU237F, LEU241E, LEU241F, LEU32E, LEU32F, LEU374E, LEU374F, LEU378E, LEU378F, LEU389E, LEU389F, LEU52E, LEU52F, LEU62E, LEU62F, LEU74E, LEU74F, LEU80E, LEU80F, LYS109E, LYS109F, LYS238E, LYS238F, LYS275E, LYS275F, LYS29E, LYS29F, LYS30E, LYS30F, LYS44E, LYS44F, MET103F, MET117E, MET117F, MET277E, MET277F, PHE209E, PHE209F, PHE214E, PHE214F, PHE393E, PRO111E, PRO111F, PRO132E, PRO132F, PRO377E, PRO377F, PRO390E, PRO390F, PRO47E, PRO47F, PRO58E, PRO58F, PRO81E, PRO81F, SER102E, SER102F, SER105E, SER105F, SER125E, SER125F, SER212E, SER212F, SER221E, SER221F, SER224E, SER224F, SER228E, SER228F, SER379E, SER379F, SER43E, SER43F, SER51E, SER51F, THR122E, THR122F, THR213E, THR213F, THR220E, THR220F, THR222E, THR222F, THR231E, THR231F, THR370E, THR370F, THR392E, THR39E, THR39F, THR40E, THR40F, THR49E, THR49F, THR53E, THR53F, TYR126E, TYR126F, TYR227E, TYR227F, TYR284E, TYR284F, TYR381E, TYR381F, TYR54E, TYR54F, TYR57E, TYR57F, VAL119E, VAL119F, VAL120E, VAL120F, VAL218E, VAL218F, VAL219E, VAL219F, VAL230E, VAL230F, VAL283E, VAL283F, VAL35E, VAL35F, VAL36E, VAL36F, VAL37E, VAL37F, VAL388E, VAL388F, VAL45E, VAL45F, VAL46E, VAL46F, VAL59E, VAL59F, VAL71E, VAL71F
• E-G: ALA84G, ALA87G, ARG141G, ARG77G, ASP83G, GLU79G, GLU85G, GLY391E, LEU389E, LEU86G, LEU88G, PHE393E, PHE73G, PHE89G, PRO390E, PRO81G, THR392E, THR82G, VAL388E
• F-G: ALA129G, ALA139G, ALA142G, ALA169G, ALA177F, ALA192F, ALA63F, ALA64F, ALA84F, ALA84G, ALA87F, ALA87G, ALA95G, ARG101G, ARG141G, ARG146G, ARG296F, ARG300F, ARG305F, ARG65F, ARG77G, ARG92G, ARG94F, ARG94G, ARG97G, ARG98G, ASP100G, ASP131G, ASP133G, ASP136G, ASP61F, ASP83F, ASP83G, CYS66F, GLN178F, GLN199F, GLN70F, GLN91G, GLU130G, GLU134G, GLU187F, GLU190F, GLU198F, GLU299F, GLU69F, GLU85G, GLY173F, GLY173G, GLY175F, GLY302F, HIS171F, HIS171G, HIS182F, ILE202F, LEU104G, LEU127G, LEU174F, LEU62F, LEU74F, LEU80F, LEU86F, LEU86G, LEU88G, LYS143G, MET103G, PHE73G, PHE89G, PRO132G, PRO170G, PRO189F, PRO81F, SER102G, SER172F, SER172G, SER195F, SER67F, SER90F, SER90G, SER96G, THR191F, THR303F, THR82F, TYR227G, TYR57F, VAL150G, VAL188F, VAL193F, VAL194F, VAL301F, VAL304F, VAL71F, VAL99G
• F-H: ARG300F, ARG305F, ASN113H, ASP112H, ASP306F, CYS114H, GLN308F, GLU299F, GLY302F, GLY307F, LEU311F, PRO111H, THR303F, VAL304F
• G-H: ALA108G, ALA108H, ALA123G, ALA123H, ALA129G, ALA129H, ALA211G, ALA211H, ALA215G, ALA215H, ALA216G, ALA216H, ALA229G, ALA229H, ALA233G, ALA233H, ALA236G, ALA236H, ALA245G, ALA33G, ALA33H, ALA371G, ALA371H, ALA373G, ALA373H, ALA380G, ALA380H, ALA41G, ALA41H, ALA63G, ALA63H, ALA64G, ALA64H, ARG121G, ARG121H, ARG161G, ARG161H, ARG162G, ARG162H, ARG217G, ARG217H, ARG240G, ARG240H, ARG282G, ARG282H, ARG290G, ARG290H, ARG357G, ARG357H, ARG376G, ARG376H, ARG387G, ARG387H, ARG55G, ARG55H, ARG65G, ARG65H, ARG77G, ARG77H, ASN113G, ASN113H, ASN210G, ASN210H, ASN372G, ASN372H, ASN50H, ASP112G, ASP118G, ASP118H, ASP131G, ASP131H, ASP135G, ASP135H, ASP225G, ASP225H, ASP27G, ASP27H, ASP38G, ASP38H, ASP61G, ASP61H, CYS114G, CYS114H, CYS382G, CYS382H, CYS66G, CYS66H, GLN223G, GLN223H, GLN368G, GLN368H, GLN386G, GLN386H, GLN48G, GLN48H, GLN60G, GLN60H, GLN70G, GLN70H, GLU130G, GLU130H, GLU134G, GLU134H, GLU206G, GLU206H, GLU367G, GLU367H, GLU385G, GLU385H, GLU79G, GLU79H, GLY128G, GLY128H, GLY208G, GLY208H, GLY232G, GLY232H, GLY235G, GLY235H, GLY239G, GLY239H, GLY243G, GLY243H, GLY244G, GLY244H, GLY280H, GLY31G, GLY31H, GLY34G, GLY34H, GLY383G, GLY383H, GLY391H, GLY56G, GLY56H, GLY78G, GLY78H, HIS115G, HIS115H, HIS207G, HIS207H, HIS242G, HIS242H, HIS281G, HIS281H, HIS364G, HIS364H, HIS384G, HIS384H, ILE124G, ILE124H, ILE226G, ILE226H, ILE234G, ILE234H, ILE28G, ILE28H, ILE375G, ILE375H, ILE42G, ILE42H, LEU106G, LEU106H, LEU107G, LEU107H, LEU110G, LEU110H, LEU127G, LEU127H, LEU237G, LEU237H, LEU241G, LEU241H, LEU32G, LEU32H, LEU374G, LEU374H, LEU378G, LEU378H, LEU389G, LEU389H, LEU52G, LEU52H, LEU62G, LEU62H, LEU74G, LEU74H, LEU80G, LEU80H, LYS109G, LYS109H, LYS238G, LYS238H, LYS275G, LYS275H, LYS29G, LYS29H, LYS30G, LYS30H, LYS44G, LYS44H, MET117G, MET117H, MET147H, MET277G, MET277H, PHE209G, PHE209H, PHE214G, PHE214H, PRO111G, PRO111H, PRO132G, PRO132H, PRO377G, PRO377H, PRO390G, PRO390H, PRO47G, PRO47H, PRO58G, PRO58H, PRO81H, SER102G, SER102H, SER105G, SER105H, SER125G, SER125H, SER212G, SER212H, SER221G, SER221H, SER224G, SER224H, SER228G, SER228H, SER379G, SER379H, SER43G, SER43H, SER51G, SER51H, THR122G, THR122H, THR213G, THR213H, THR220G, THR220H, THR222G, THR222H, THR231G, THR231H, THR350G, THR370G, THR370H, THR39G, THR39H, THR40G, THR40H, THR49G, THR49H, THR53G, THR53H, TYR126G, TYR126H, TYR227G, TYR227H, TYR284G, TYR284H, TYR381G, TYR381H, TYR54G, TYR54H, TYR57G, TYR57H, VAL119G, VAL119H, VAL120G, VAL120H, VAL218G, VAL218H, VAL219G, VAL219H, VAL230G, VAL230H, VAL283G, VAL283H, VAL35G, VAL35H, VAL36G, VAL36H, VAL37G, VAL37H, VAL388G, VAL388H, VAL45G, VAL45H, VAL46G, VAL46H, VAL59G, VAL59H, VAL71G, VAL71H