3HTU

crystal structure of the human vps25-vps20 subcomplex

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 60
  • Norm. En. per Res.: -6.0483
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.9993	-58.8178	-207.612	-339.429	59	11	4	8001	6	27	23
A-D	0.0	0.0	-1.3087	-1.3087	8	0	0	85	0	1	2
A-E	-8.9037	3.9346	-29.3799	-34.3489	30	2	0	1530	0	23	18
B-C	0.0	0.0	-0.0027	-0.0027	3	0	0	4	0	1	0
B-D	-6.0559	4.8244	-201.241	-202.4724	60	4	8	8569	0	18	34
B-E	0.0	-11.8472	-11.3043	-23.1515	15	1	0	684	0	13	11
C-D	-74.6445	-60.58	-227.675	-362.8995	60	11	5	8654	5	27	18
E-F	-65.6565	-74.3369	-190.641	-330.6345	64	12	5	7844	5	26	20
E-H	0.0	0.0	-1.3098	-1.3098	9	0	0	152	0	2	1
F-G	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	1	0
F-H	-7.4861	1.1889	-195.683	-201.9802	54	12	10	8305	0	11	30
G-H	-58.1108	-79.1891	-205.651	-342.951	64	17	5	8194	10	30	20

Interface residues

• A-B: ALA162A, ALA19B, ARG12B, ARG171A, ARG27B, ARG31B, ASN121A, ASN122A, ASN132A, ASP135A, ASP169A, ASP17B, ASP28B, GLN157A, GLN16B, GLN22B, GLN25B, GLN26B, GLN32B, GLU129A, GLU134A, GLU137A, GLU159A, GLU163A, GLY10B, GLY133A, GLY170A, GLY172A, HIS142A, HIS160A, ILE164A, ILE165A, ILE20B, LEU127A, LEU130A, LEU156A, LEU21B, LEU23B, LYS161A, LYS174A, LYS18B, LYS24B, LYS29B, LYS35B, PHE125A, PHE175A, PHE176A, SER11B, SER123A, SER168A, THR126A, THR14B, THR166A, TYR128A, TYR33B, VAL124A, VAL13B, VAL167A, VAL173A
• A-D: ARG45D, ASN121A, ASN122A, GLU129A, LEU41D, SER123A, THR126A, VAL124A
• A-E: ALA147A, ALA155E, ARG102A, ARG103A, ARG103E, ARG151E, ASN132A, ASP145A, GLN158E, GLU105E, GLU106E, GLU137A, GLU140A, GLU146A, GLU159E, GLY133A, GLY143A, HIS142A, HIS160E, LEU144A, LEU156E, LYS109E, LYS161E, PHE141A, PRO104A, PRO104E, THR131A, THR148A, TRP107A, TYR128A
• B-C: LEU41B, THR126C, VAL124C
• B-D: ALA19B, ALA19D, ALA38B, ALA38D, ARG27B, ARG27D, ARG31B, ARG31D, ARG36B, ARG36D, ARG43B, ARG43D, ARG45D, ASP17B, ASP17D, ASP28B, ASP28D, GLN16B, GLN16D, GLN22B, GLN22D, GLN25B, GLN25D, GLN26B, GLN26D, GLN32B, GLN32D, GLN34B, GLN34D, GLN39B, GLN39D, GLN40B, GLN40D, GLU15B, GLU15D, GLU42B, GLU42D, GLU44B, GLU44D, ILE20B, ILE20D, ILE37B, ILE37D, LEU21B, LEU21D, LEU23B, LEU23D, LEU30B, LEU30D, LEU41B, LEU41D, LYS18B, LYS24B, LYS24D, LYS29B, LYS29D, LYS35B, LYS35D, TYR33B, TYR33D
• B-E: ALA38B, ARG102E, ARG103E, ARG36B, ARG43B, GLN32B, GLN39B, GLN40B, GLU106E, GLU140E, GLU42B, LEU110E, LYS109E, LYS35B, TRP107E
• C-D: ALA162C, ALA19D, ARG12D, ARG171C, ARG27D, ARG31D, ASN122C, ASN132C, ASP135C, ASP169C, ASP17D, ASP28D, GLN120C, GLN157C, GLN16D, GLN22D, GLN25D, GLN26D, GLN32D, GLU129C, GLU134C, GLU159C, GLU15D, GLU163C, GLY10D, GLY133C, GLY170C, GLY172C, HIS142C, HIS160C, ILE164C, ILE165C, ILE20D, LEU127C, LEU130C, LEU156C, LEU21D, LEU23D, LYS161C, LYS174C, LYS18D, LYS24D, LYS29D, LYS35D, PHE125C, PHE175C, PHE176C, SER11D, SER123C, SER168C, THR126C, THR131C, THR14D, THR166C, TYR128C, TYR33D, VAL124C, VAL13D, VAL167C, VAL173C
• E-F: ALA162E, ALA19F, ARG12F, ARG171E, ARG27F, ARG31F, ARG36F, ASN122E, ASN132E, ASP135E, ASP169E, ASP17F, ASP28F, GLN120E, GLN157E, GLN158E, GLN16F, GLN22F, GLN25F, GLN26F, GLN32F, GLU129E, GLU134E, GLU137E, GLU159E, GLU163E, GLY10F, GLY133E, GLY170E, GLY172E, HIS142E, HIS160E, ILE164E, ILE165E, ILE20F, LEU127E, LEU130E, LEU156E, LEU21F, LEU23F, LYS161E, LYS174E, LYS18F, LYS24F, LYS29F, LYS35F, PHE125E, PHE175E, PHE176E, SER11F, SER123E, SER168E, THR126E, THR131E, THR136E, THR14F, THR166E, TRP114E, TYR128E, TYR33F, VAL124E, VAL13F, VAL167E, VAL173E
• E-H: ARG45H, GLN120E, GLN34H, GLU129E, GLU134E, LEU41H, PHE125E, SER123E, VAL124E
• F-G: LEU41F, THR126G
• F-H: ALA19F, ALA19H, ALA38F, ALA38H, ARG27F, ARG27H, ARG31F, ARG31H, ARG36F, ARG36H, ARG43H, ARG45H, ASP17F, ASP28F, ASP28H, GLN16F, GLN22F, GLN22H, GLN25F, GLN25H, GLN26F, GLN26H, GLN32F, GLN32H, GLN34F, GLN34H, GLN39F, GLN39H, GLN40F, GLN40H, GLU15F, GLU42H, GLU44H, ILE20F, ILE20H, ILE37F, ILE37H, LEU21F, LEU21H, LEU23F, LEU23H, LEU30F, LEU30H, LEU41F, LEU41H, LYS18F, LYS24F, LYS24H, LYS29F, LYS29H, LYS35F, LYS35H, TYR33F, TYR33H
• G-H: ALA162G, ALA19H, ARG12H, ARG171G, ARG27H, ARG31H, ASN121G, ASN122G, ASN132G, ASP135G, ASP169G, ASP17H, ASP28H, GLN120G, GLN157G, GLN16H, GLN22H, GLN25H, GLN26H, GLN32H, GLU129G, GLU134G, GLU137G, GLU146G, GLU159G, GLU163G, GLY10H, GLY133G, GLY170G, GLY172G, HIS142G, HIS160G, ILE164G, ILE165G, ILE20H, LEU127G, LEU130G, LEU156G, LEU21H, LEU23H, LYS161G, LYS174G, LYS18H, LYS24H, LYS29H, LYS35H, PHE125G, PHE175G, PHE176G, SER11H, SER123G, SER168G, THR126G, THR131G, THR14H, THR166G, TRP114G, TYR112G, TYR128G, TYR33H, VAL124G, VAL13H, VAL167G, VAL173G