3HRZ

cobra venom factor (cvf) in complex with human factor b

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 227
  • Norm. En. per Res.: -4.4484
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-378.977	-42.7232	-399.969	-821.6692	227	52	39	40586	5	61	49
A-C	-18.8759	-28.008	-196.236	-243.1199	105	3	9	8597	1	18	15
A-D	0.0	-21.5614	-59.3684	-80.9298	57	1	0	2923	1	5	7
B-C	-517.9778	-69.3005	-422.509	-1009.7873	227	81	29	40429	4	48	38
B-D	-92.5541	-59.7124	-255.524	-407.7905	112	14	2	9655	10	57	56
C-D	-81.3834	-47.1013	-267.548	-396.0327	114	11	1	10059	5	33	39

Interface residues

• A-B: ALA539A, ALA540A, ALA551A, ALA557A, ALA561A, ALA574A, ALA769B, ALA781B, ALA812B, ALA857B, ARG124A, ARG195A, ARG228A, ARG552A, ARG726B, ARG759B, ARG787B, ARG811B, ARG856B, ASN159A, ASN532A, ASN745B, ASN816B, ASP111A, ASP129A, ASP168A, ASP305A, ASP491A, ASP531A, ASP548A, ASP559A, ASP728B, ASP739B, ASP760B, ASP795B, ASP885B, CYS522A, CYS779B, GLN109A, GLN535A, GLN573A, GLN747B, GLN797B, GLN899B, GLN944B, GLU203A, GLU233A, GLU234A, GLU236A, GLU301A, GLU546A, GLU742B, GLU743B, GLU782B, GLU785B, GLU809B, GLU936B, GLU938B, GLY113A, GLY118A, GLY232A, GLY303A, GLY524A, GLY530A, GLY538A, GLY547A, GLY550A, GLY554A, GLY748B, GLY777B, HIS130A, HIS815B, ILE108A, ILE114A, ILE149A, ILE493A, ILE534A, ILE543A, ILE571A, ILE576A, ILE580A, ILE749B, ILE762B, ILE778B, ILE786B, ILE813B, ILE937B, ILE942B, LEU106A, LEU122A, LEU150A, LEU158A, LEU169A, LEU172A, LEU199A, LEU230A, LEU526A, LEU533A, LEU545A, LEU555A, LEU565A, LEU734B, LEU736B, LEU740B, LEU758B, LEU768B, LEU796B, LEU853B, LEU869B, LEU891B, LYS112A, LYS196A, LYS464A, LYS529A, LYS542A, LYS544A, LYS560A, LYS570A, LYS575A, LYS731B, LYS738B, LYS752B, LYS776B, LYS790B, LYS889B, LYS892B, LYS900B, LYS940B, MET128A, MET306A, MET523A, MET536A, MET541A, MET754B, MET789B, MET798B, PHE105A, PHE107A, PHE126A, PHE161A, PHE202A, PHE729B, PHE756B, PHE772B, PHE792B, PHE793B, PRO117A, PRO120A, PRO163A, PRO167A, PRO200A, PRO490A, PRO537A, PRO549A, PRO730B, PRO744B, PRO774B, PRO783B, PRO799B, PRO859B, SER104A, SER119A, SER127A, SER171A, SER201A, SER302A, SER304A, SER572A, SER727B, SER732B, SER750B, SER751B, SER755B, SER761B, SER771B, SER801B, SER855B, SER901B, THR110A, THR116A, THR300A, THR521A, THR525A, THR737B, THR741B, THR753B, THR763B, THR764B, THR773B, THR775B, THR939B, TRP577A, TRP733B, TRP735B, TRP765B, TRP883B, TYR115A, TYR123A, TYR197A, TYR229A, TYR231A, TYR563A, TYR757B, TYR784B, TYR800B, TYR817B, VAL121A, VAL125A, VAL151A, VAL170A, VAL198A, VAL235A, VAL307A, VAL527A, VAL528A, VAL553A, VAL556A, VAL558A, VAL562A, VAL766B, VAL767B, VAL770B, VAL780B, VAL788B, VAL791B, VAL858B, VAL894B
• A-C: ALA1275C, ALA1278C, ALA1400C, ALA239A, ARG1279C, ARG1384C, ARG1388C, ARG260A, ASN1274C, ASN1308C, ASN1406C, ASN154A, ASP1361C, ASP1383C, ASP1443C, ASP168A, ASP256A, ASP265A, ASP305A, ASP75A, GLN1397C, GLN144A, GLU1273C, GLU1282C, GLU1390C, GLU142A, GLU236A, GLU301A, GLY1381C, GLY148A, GLY237A, GLY303A, HIS183A, ILE1359C, ILE1362C, ILE1386C, ILE1402C, ILE1403C, ILE149A, ILE254A, ILE261A, ILE263A, ILE264A, LEU1276C, LEU1277C, LEU1304C, LEU1405C, LEU1442C, LEU150A, LEU169A, LEU242A, LEU258A, LYS1284C, LYS1398C, LYS1407C, LYS1435C, LYS180A, MET1357C, MET299A, MET306A, PHE1306C, PHE143A, PHE240A, PHE243A, PRO167A, PRO255A, PRO262A, SER1363C, SER1387C, SER1438C, SER152A, SER153A, SER253A, SER257A, SER295A, SER302A, SER304A, THR1280C, THR1305C, THR1356C, THR1358C, THR145A, THR259A, THR297A, THR300A, TYR1272C, TYR1307C, TYR1385C, TYR1389C, TYR1404C, TYR1437C, TYR1439C, TYR1440C, TYR164A, TYR293A, VAL1382C, VAL1399C, VAL1401C, VAL151A, VAL170A, VAL238A, VAL241A, VAL296A, VAL298A, VAL308A
• A-D: ALA137D, ALA539A, ALA540A, ALA557A, ARG124A, ARG157D, ARG552A, ARG80D, ARG92D, ASN135D, ASN142D, ASN159A, ASN165A, ASN86D, ASP108D, ASP134D, ASP168A, GLN155D, GLU85D, GLU88D, GLY109D, GLY118A, GLY136D, GLY138D, GLY153D, GLY538A, GLY554A, LEU122A, LEU166A, LEU169A, LEU555A, LYS542A, MET541A, PHE160A, PHE161A, PRO117A, PRO120A, PRO163A, PRO167A, PRO537A, PRO91D, PRO94D, SER119A, SER154D, SER93D, THR111D, TRP162A, TRP90D, TYR107D, TYR110D, TYR123A, TYR156D, TYR164A, VAL121A, VAL170A, VAL553A, VAL556A
• B-C: ALA1275C, ALA1278C, ALA1293C, ALA1299C, ALA1309C, ALA1396C, ALA1400C, ALA1471C, ALA812B, ALA833B, ALA837B, ALA857B, ALA912B, ALA925B, ARG1262C, ARG1279C, ARG1388C, ARG1469C, ARG811B, ARG845B, ARG856B, ARG911B, ARG926B, ARG931B, ASN1252C, ASN1271C, ASN1274C, ASN1286C, ASN1308C, ASN1460C, ASN1466C, ASN1497C, ASN1582C, ASN805B, ASN831B, ASP1254C, ASP1288C, ASP1296C, ASP1361C, ASP1392C, ASP909B, ASP929B, ASP930B, ASP934B, ASP946B, CYS1463C, CYS1468C, CYS1470C, CYS835B, GLN1287C, GLN1310C, GLN1397C, GLN1430C, GLN807B, GLN842B, GLN846B, GLN847B, GLN867B, GLN899B, GLN919B, GLN944B, GLU1258C, GLU1282C, GLU1390C, GLU1425C, GLU1473C, GLU806B, GLU809B, GLU866B, GLU896B, GLU921B, GLU936B, GLU938B, GLY1295C, GLY1297C, GLY1367C, GLY1427C, GLY1432C, GLY1457C, GLY1465C, GLY1472C, GLY841B, GLY897B, GLY914B, GLY916B, GLY917B, GLY945B, HIS1423C, HIS1451C, ILE1255C, ILE1257C, ILE1266C, ILE1270C, ILE1289C, ILE1303C, ILE1362C, ILE1402C, ILE1429C, ILE1462C, ILE1464C, ILE810B, ILE813B, ILE850B, ILE862B, ILE902B, ILE905B, ILE923B, ILE937B, ILE941B, ILE942B, ILE943B, LEU1251C, LEU1253C, LEU1259C, LEU1276C, LEU1277C, LEU1285C, LEU1304C, LEU1311C, LEU1365C, LEU1369C, LEU1458C, LEU1459C, LEU828B, LEU865B, LEU908B, LEU920B, LEU928B, LYS1284C, LYS1298C, LYS1398C, LYS1435C, LYS1445C, LYS1448C, LYS1454C, LYS1461C, LYS1581C, LYS804B, LYS840B, LYS851B, LYS900B, LYS907B, LYS913B, LYS924B, LYS927B, LYS940B, MET1301C, MET1364C, MET1395C, PHE1306C, PHE1368C, PHE1424C, PHE1428C, PHE1449C, PHE834B, PHE848B, PHE860B, PRO1260C, PRO1370C, PRO1431C, PRO799B, PRO832B, PRO849B, PRO859B, PRO864B, PRO895B, PRO910B, PRO933B, PRO947B, SER1294C, SER1363C, SER1433C, SER1566C, SER801B, SER836B, SER838B, SER854B, SER855B, SER901B, THR1256C, THR1280C, THR1283C, THR1290C, THR1292C, THR1300C, THR1302C, THR1305C, THR1366C, THR1447C, THR1456C, THR1474C, THR839B, THR904B, THR918B, THR935B, THR939B, TYR1268C, TYR1272C, TYR1307C, TYR1437C, TYR1450C, TYR800B, TYR823B, TYR830B, TYR844B, VAL1281C, VAL1291C, VAL1317C, VAL1399C, VAL1401C, VAL1426C, VAL1434C, VAL1467C, VAL802B, VAL803B, VAL808B, VAL826B, VAL858B, VAL861B, VAL863B, VAL894B, VAL898B, VAL903B, VAL906B, VAL915B, VAL922B, VAL932B
• B-D: ALA719B, ALA833B, ARG150D, ARG157D, ARG168D, ARG177D, ARG69D, ARG726B, ARG74D, ARG759B, ARG80D, ARG843B, ARG845B, ARG888B, ARG92D, ASN831B, ASN86D, ASP108D, ASP160D, ASP64D, ASP720B, ASP722B, ASP728B, ASP760B, ASP83D, ASP871B, CYS106D, CYS133D, CYS166D, GLN155D, GLN176D, GLN63D, GLN65D, GLN842B, GLN867B, GLU159D, GLU72D, GLU827B, GLU85D, GLU866B, GLU873B, GLU88D, GLU936B, GLU938B, GLY109D, GLY148D, GLY153D, GLY841B, GLY868B, GLY87D, HIS105D, HIS165D, HIS82D, HIS870B, ILE145D, ILE723B, ILE724B, LEU734B, LEU736B, LEU758B, LEU829B, LEU869B, LYS151D, LYS61D, LYS66D, LYS738B, LYS840B, LYS875B, LYS889B, LYS890B, LYS892B, LYS940B, MET754B, PHE729B, PHE756B, PHE84D, PRO730B, PRO81D, PRO832B, PRO91D, PRO94D, SER154D, SER161D, SER167D, SER721B, SER725B, SER727B, SER732B, SER755B, SER761B, SER838B, SER93D, THR149D, THR163D, THR62D, THR67D, THR737B, THR839B, THR939B, TRP733B, TRP735B, TRP90D, TYR107D, TYR110D, TYR44D, TYR757B, TYR830B, TYR844B, TYR89D, TYR95D, VAL152D, VAL872B
• C-D: ALA1493C, ALA290D, ARG1262C, ARG1565C, ARG157D, ARG177D, ARG390D, ARG52D, ASN1497C, ASN1582C, ASN329D, ASN368D, ASN410D, ASN413D, ASP1261C, ASP1485C, ASP1499C, ASP1531C, ASP160D, ASP251D, ASP364D, ASP372D, CYS1494C, CYS1618C, CYS180D, CYS51D, GLN1287C, GLN1489C, GLN1528C, GLN155D, GLN31D, GLN335D, GLN65D, GLU1263C, GLU1282C, GLU1491C, GLU1495C, GLU1532C, GLU159D, GLU1615C, GLU182D, GLU379D, GLY1529C, GLY1617C, GLY252D, GLY254D, GLY257D, GLY327D, GLY365D, GLY370D, GLY371D, GLY55D, HIS322D, HIS367D, ILE1266C, ILE1490C, ILE1526C, ILE256D, ILE374D, LEU1259C, LEU1285C, LEU1488C, LEU158D, LEU1613C, LEU324D, LEU366D, LEU408D, LYS1284C, LYS1492C, LYS1527C, LYS323D, LYS325D, LYS331D, LYS332D, LYS391D, LYS61D, MET369D, PHE1616C, PRO1260C, PRO1487C, PRO1619C, PRO373D, SER161D, SER253D, SER255D, SER326D, SER53D, SER56D, SER58D, THR1280C, THR1283C, THR1496C, THR1530C, THR1612C, THR1614C, THR1620C, THR179D, THR291D, THR328D, THR375D, THR50D, THR54D, TYR139D, TYR1500C, TYR1611C, TYR292D, TYR319D, VAL1264C, VAL1281C, VAL1486C, VAL1498C, VAL1501C, VAL1525C, VAL376D