3HQQ

crystal structure of leishmania mexicana pyruvate kinase (lmpyk) in complex with fructose 2,6 bisphosphate

• Total interactions analyzed: 276
• Total true interactions: 43
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 16
  • Norm. En. per Res.: -3.0524
• Hub Node: C(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-I	-28.1677	-18.5122	-373.108	-419.7879	212	51	32	23861	4	54	42
A-J	-10.6575	-27.9195	-202.778	-241.355	105	13	7	10926	2	35	38
B-C	-9.1531	-5.9376	-433.669	-448.7596	215	80	27	25932	2	51	42
B-G	0.0	-27.1242	-22.7273	-49.8515	44	3	0	1434	2	24	23
B-O	0.0	-28.1734			16
C-E	-8.0887	-70.19	-61.3463	-139.625	67	11	0	2973	6	36	39
C-G	0.0	7.7281	-1.845	5.8831	16	0	0	373	0	2	9
C-I	0.0	0.0	-2.073	-2.073	17	0	0	310	0	7	1
C-N	-10.5003	-20.9618	-0.0705	-31.5326	12	0	0	19	0	1	0
C-P	0.0	-24.6394			16
C-V	0.0	-5.4933			5
D-E	-16.5175	-33.4075	-259.378	-309.303	105	30	8	11963	2	36	40
D-F	-11.1338	-13.5659	-442.971	-467.6706	208	30	24	24351	2	52	42
E-G	-6.0492	-8.9477	-440.352	-455.3489	210	49	27	25285	2	51	40
F-G	-17.526	-30.909	-130.864	-179.299	102	52	6	11267	2	36	41
H-I	-8.3226	-24.0685	-167.666	-200.0571	101	40	5	10322	1	34	39
H-J	-24.553	-1.0257	-242.178	-267.7567	219	150	27	27277	2	53	42
H-M	0.0	-4.2701	-8.8475	-13.1175	23	16	1	1767	1	9	11
I-L	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	2	0
I-M	-4.054	26.118	-31.1915	-9.1275	64	27	0	4149	0	38	42
I-N	0.0	-5.6588	0.0	-5.6588	5	0	0	0	0	0	0
J-M	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	2	0
K-L	-9.1807	-27.9866	-212.646	-249.8133	103	32	6	10919	2	34	40
K-M	-14.5028	-9.1846	-409.079	-432.7663	220	75	30	26661	2	52	43
K-S	0.0	-5.2639			5
L-N	-32.2153	-9.8688	9.2621	-32.8219	89	53	10	7132	0	4	4
L-O	0.0	-23.0465			8
L-S	-10.2624	25.6818			14
L-T	0.0	-5.312			4
M-N	-18.8308	-30.0069	0.0	-48.8377	16	0	0	0	0	0	0
N-O	-6.4836	2.5544			6
N-P	0.0	3.434			2
O-P	-12.4484	-8.7793			30
P-U	0.0	-5.4933			5
P-V	-7.8641	9.5706			15
Q-R	-15.3773	-30.3685			17
Q-S	-11.9693	-12.2716			31
R-T	-11.0652	-9.8169			29
S-T	-30.5661	-31.1882			18
U-V	-15.717	-25.4797			17
U-W	-39.1177	-1.4373			32
V-X	-24.4741	-19.064			32
W-X	-20.3612	-28.1787			17

Interface residues

• A-I: ALA261A, ALA261I, ALA271A, ALA271I, ALA277A, ALA277I, ALA288A, ALA288I, ALA295A, ALA295I, ALA311A, ALA311I, ALA317A, ALA317I, ALA319A, ALA319I, ALA347I, ALA353A, ALA353I, ALA356A, ALA356I, ALA4A, ALA4I, ARG262A, ARG262I, ARG307A, ARG307I, ARG310A, ARG310I, ARG348A, ARG348I, ASN167A, ASN167I, ASN241A, ASN241I, ASN247A, ASN286A, ASN286I, ASN318A, ASN318I, ASN322A, ASN322I, ASN364A, ASN364I, ASN6A, ASN6I, ASP13A, ASP13I, ASP144A, ASP144I, ASP145A, ASP145I, ASP249A, ASP249I, ASP264A, ASP264I, ASP315A, ASP315I, CYS285A, CYS285I, CYS350A, CYS350I, GLN243A, GLN243I, GLN246A, GLN246I, GLN278A, GLN278I, GLN297A, GLN297I, GLN2A, GLN2I, GLN370A, GLN370I, GLU268A, GLU268I, GLU272A, GLU272I, GLU300A, GLU300I, GLU312A, GLU312I, GLU352A, GLU352I, GLY146A, GLY146I, GLY181I, GLY263A, GLY263I, GLY266A, GLY266I, GLY323A, GLY323I, HIS169A, HIS169I, HIS242A, HIS242I, HIS5A, HIS5I, ILE11A, ILE11I, ILE147A, ILE147I, ILE149A, ILE149I, ILE248A, ILE248I, ILE269A, ILE269I, ILE280A, ILE280I, ILE282A, ILE282I, ILE349A, ILE349I, ILE366A, ILE366I, LEU148A, LEU148I, LEU265A, LEU265I, LEU281A, LEU281I, LEU299A, LEU299I, LEU351A, LEU351I, LEU357A, LEU357I, LEU369A, LEU369I, LEU3A, LEU3I, LEU7A, LEU7I, LEU9A, LEU9I, LYS273A, LYS273I, LYS279A, LYS279I, LYS284A, LYS284I, LYS367A, LYS367I, LYS368A, LYS368I, MET298A, MET298I, MET346I, PHE12A, PHE12I, PHE321A, PHE321I, PHE362A, PHE362I, PRO14A, PRO14I, PRO180I, PRO270A, PRO270I, PRO306A, PRO306I, PRO308A, PRO308I, SER10A, SER10I, SER168I, SER1A, SER1I, SER283A, SER283I, SER301A, SER301I, SER314A, SER314I, SER355A, SER355I, SER365A, SER365I, THR296A, THR296I, THR309A, THR309I, THR8A, THR8I, TYR142A, TYR142I, TYR345A, TYR345I, VAL15A, VAL15I, VAL245A, VAL245I, VAL267A, VAL267I, VAL274A, VAL274I, VAL275A, VAL275I, VAL276A, VAL276I, VAL287A, VAL287I, VAL313A, VAL313I, VAL316A, VAL316I, VAL320A, VAL320I, VAL361A, VAL361I
• A-J: ALA376A, ALA376J, ALA379A, ALA379J, ALA384A, ALA384J, ALA393A, ALA393J, ALA481A, ALA481J, ALA489A, ALA489J, ARG493A, ARG493J, ASN364A, ASN364J, ASN386A, ASN386J, ASN415A, ASN490A, ASN490J, ASP377A, ASP377J, ASP482A, ASP482J, CYS381A, CYS381J, CYS476A, GLN370A, GLN370J, GLN491A, GLN491J, GLU378A, GLU378J, GLU390A, GLU390J, GLU454A, GLU454J, GLU498A, GLU498J, GLY452A, GLY452J, HIS371A, HIS371J, HIS480A, HIS480J, HIS483A, HIS483J, ILE372A, ILE372J, ILE494A, ILE494J, LEU495A, LEU495J, LEU496A, LEU496J, LYS367A, LYS367J, LYS368A, LYS368J, LYS392A, LYS392J, LYS394A, LYS484A, LYS484J, MET374A, MET374J, PHE363A, PHE363J, PRO373A, PRO373J, SER375A, SER375J, SER382A, SER382J, SER383A, SER383J, SER387A, SER387J, THR391A, THR391J, THR492A, THR492J, TYR360A, TYR360J, TYR389A, TYR389J, TYR412A, TYR412J, TYR475A, TYR475J, TYR488A, TYR488J, VAL380A, VAL380J, VAL385A, VAL385J, VAL388A, VAL388J, VAL477A, VAL477J, VAL478A, VAL478J, VAL485A, VAL485J
• B-C: ALA261B, ALA261C, ALA271B, ALA271C, ALA277B, ALA277C, ALA288B, ALA288C, ALA295B, ALA295C, ALA311B, ALA311C, ALA317B, ALA317C, ALA319B, ALA319C, ALA353B, ALA353C, ALA356B, ALA356C, ALA4B, ALA4C, ARG262B, ARG262C, ARG307B, ARG307C, ARG310B, ARG310C, ARG348B, ARG348C, ASN167B, ASN167C, ASN241B, ASN241C, ASN286B, ASN286C, ASN305B, ASN318B, ASN318C, ASN322B, ASN322C, ASN358C, ASN364B, ASN364C, ASN6B, ASN6C, ASP13B, ASP13C, ASP144B, ASP144C, ASP145B, ASP145C, ASP249B, ASP249C, ASP264B, ASP264C, ASP315B, ASP315C, CYS285B, CYS285C, CYS294C, CYS350B, CYS350C, GLN243B, GLN243C, GLN246B, GLN246C, GLN278B, GLN278C, GLN297B, GLN297C, GLN2B, GLN2C, GLN354C, GLN370B, GLN370C, GLU268B, GLU268C, GLU272B, GLU272C, GLU300B, GLU300C, GLU312B, GLU312C, GLU332B, GLU352B, GLU352C, GLY146B, GLY146C, GLY181B, GLY181C, GLY263B, GLY263C, GLY266B, GLY266C, GLY323B, GLY323C, HIS169B, HIS242B, HIS242C, HIS5B, HIS5C, ILE11B, ILE11C, ILE147B, ILE147C, ILE149B, ILE149C, ILE239B, ILE248B, ILE269B, ILE269C, ILE280B, ILE280C, ILE282B, ILE282C, ILE349B, ILE349C, ILE366B, ILE366C, LEU148B, LEU148C, LEU265B, LEU265C, LEU281B, LEU281C, LEU299B, LEU299C, LEU351B, LEU351C, LEU357B, LEU357C, LEU369B, LEU369C, LEU3B, LEU3C, LEU7B, LEU7C, LEU9B, LEU9C, LYS273B, LYS273C, LYS279B, LYS279C, LYS284B, LYS284C, LYS367B, LYS367C, LYS368B, LYS368C, MET298B, MET298C, PHE12B, PHE12C, PHE321B, PHE321C, PHE362B, PHE362C, PHE363B, PHE363C, PRO14B, PRO14C, PRO180B, PRO180C, PRO270B, PRO270C, PRO306B, PRO306C, PRO308B, PRO308C, SER10B, SER10C, SER1B, SER1C, SER283B, SER283C, SER301B, SER301C, SER314B, SER314C, SER355B, SER355C, SER365B, SER365C, THR296B, THR296C, THR309B, THR309C, THR8B, THR8C, TYR304B, TYR304C, TYR345B, TYR345C, VAL15B, VAL15C, VAL245B, VAL245C, VAL267B, VAL267C, VAL274B, VAL274C, VAL275B, VAL275C, VAL276B, VAL276C, VAL287B, VAL287C, VAL313B, VAL313C, VAL316B, VAL316C, VAL320C, VAL361B, VAL361C
• B-G: ALA116G, ALA191G, ARG103B, ARG174B, ARG174G, ARG175B, ASN167B, ASP117G, ASP173B, ASP196G, ASP98B, ASP98G, GLN93B, GLN93G, GLU102B, GLU58G, GLY104B, GLY55G, GLY96B, GLY96G, GLY97B, GLY97G, HIS169B, HIS57G, LYS121B, LYS192G, LYS335B, LYS85G, MET101B, PHE199G, PHE52G, PRO29B, SER168B, SER172B, SER56G, THR166B, THR170B, TYR125G, TYR59G, VAL100B, VAL165B, VAL195G, VAL95B, VAL95G
• B-O: ARG493B, ARG493O, ASP482B, ASP482O, GLU378B, GLU378O, GLU390B, GLU390O, GLU454B, GLU454O, HIS483B, HIS483O, LYS367B, LYS367O, LYS484B, LYS484O
• C-E: ALA105E, ALA114C, ALA116C, ALA191C, ALA99E, ARG103E, ARG174C, ARG174E, ARG175E, ARG194C, ARG90C, ARG90E, ASN167E, ASP117C, ASP122E, ASP127C, ASP144E, ASP173C, ASP173E, ASP193C, ASP196C, ASP98C, ASP98E, GLN129C, GLN198C, GLN93C, GLN93E, GLU102E, GLU58C, GLU88C, GLY104E, GLY55C, GLY55E, GLY96C, GLY96E, GLY97C, GLY97E, HIS169E, HIS54E, HIS57C, HIS60C, ILE171E, LYS118C, LYS121E, LYS192C, LYS335E, LYS85C, MET101E, PHE199C, PHE52C, PHE94E, PRO113C, PRO29E, SER168E, SER172E, SER190C, SER56C, THR120E, THR166E, THR170E, THR62C, TYR125C, TYR59C, VAL100E, VAL195C, VAL95C, VAL95E
• C-G: ALA36C, ALA36G, ASN66C, GLU35C, GLU35G, LYS335C, LYS337C, LYS337G, PRO29C, PRO29G, SER33C, SER33G, TYR59C, TYR59G, VAL34C, VAL34G
• C-I: ALA36I, ASN65I, ASN66I, GLN198C, GLN32I, GLN69I, GLU35I, GLU58I, GLY96I, GLY97I, LYS229C, LYS484C, PRO228C, SER33I, THR62I, TYR59I, VAL34I
• C-N: ALA72N, ASP450N, GLU217C, GLU253C, GLU254C, GLU73N, HIS371C, HIS449N, HIS455N, ILE372C, LYS446N, PRO373C
• C-P: ARG493C, ARG493P, ASP482C, ASP482P, GLU378C, GLU378P, GLU390C, GLU390P, GLU454C, GLU454P, HIS483C, HIS483P, LYS367C, LYS367P, LYS484C, LYS484P
• C-V: ASP196V, GLU498C, GLU58V, HIS57V, LYS192V
• D-E: ALA376D, ALA376E, ALA379D, ALA379E, ALA384D, ALA384E, ALA393D, ALA393E, ALA481D, ALA481E, ALA489D, ALA489E, ARG493D, ARG493E, ASN364D, ASN364E, ASN386D, ASN386E, ASN415D, ASN490D, ASN490E, ASP377D, ASP377E, ASP482D, ASP482E, CYS381D, CYS381E, GLN370D, GLN370E, GLN491D, GLN491E, GLU378D, GLU378E, GLU390D, GLU390E, GLU454D, GLU454E, GLU498D, GLU498E, GLY452D, GLY452E, HIS371D, HIS371E, HIS480D, HIS480E, HIS483D, HIS483E, ILE372D, ILE372E, ILE494D, ILE494E, LEU495D, LEU495E, LEU496D, LEU496E, LYS367D, LYS367E, LYS368D, LYS368E, LYS392D, LYS392E, LYS394D, LYS394E, LYS484D, LYS484E, MET374D, MET374E, PHE363D, PHE363E, PRO373D, PRO373E, SER375D, SER375E, SER382D, SER382E, SER383D, SER383E, SER387D, SER387E, THR391D, THR391E, THR492D, THR492E, TYR360D, TYR360E, TYR389D, TYR389E, TYR412D, TYR412E, TYR475D, TYR475E, TYR488D, TYR488E, VAL380D, VAL380E, VAL385D, VAL385E, VAL388D, VAL388E, VAL477D, VAL477E, VAL478D, VAL478E, VAL485D, VAL485E
• D-F: ALA261D, ALA261F, ALA271D, ALA271F, ALA277D, ALA277F, ALA288D, ALA288F, ALA295D, ALA295F, ALA311D, ALA311F, ALA317D, ALA317F, ALA319D, ALA319F, ALA353D, ALA353F, ALA356D, ALA356F, ALA4D, ALA4F, ARG262D, ARG262F, ARG307D, ARG307F, ARG310D, ARG310F, ARG348D, ARG348F, ASN167D, ASN167F, ASN241D, ASN241F, ASN286D, ASN286F, ASN318D, ASN318F, ASN322D, ASN322F, ASN364D, ASN364F, ASN6D, ASN6F, ASP13D, ASP13F, ASP144D, ASP144F, ASP145D, ASP145F, ASP249D, ASP249F, ASP264D, ASP264F, ASP315D, ASP315F, CYS285D, CYS285F, CYS294F, CYS350D, CYS350F, GLN243D, GLN243F, GLN246D, GLN246F, GLN278D, GLN278F, GLN297D, GLN297F, GLN2D, GLN2F, GLN370D, GLN370F, GLU268D, GLU268F, GLU272D, GLU272F, GLU300D, GLU300F, GLU312D, GLU312F, GLU352D, GLU352F, GLY146D, GLY146F, GLY181D, GLY181F, GLY263D, GLY263F, GLY266D, GLY266F, GLY323D, GLY323F, HIS169D, HIS242D, HIS242F, HIS5D, HIS5F, ILE11D, ILE11F, ILE147D, ILE147F, ILE149D, ILE149F, ILE269D, ILE269F, ILE280D, ILE280F, ILE282D, ILE282F, ILE349D, ILE349F, ILE366D, ILE366F, LEU148D, LEU148F, LEU265D, LEU265F, LEU281D, LEU281F, LEU299D, LEU299F, LEU351D, LEU351F, LEU357D, LEU357F, LEU369D, LEU369F, LEU3D, LEU3F, LEU7D, LEU7F, LEU9D, LEU9F, LYS273D, LYS273F, LYS279D, LYS279F, LYS284D, LYS284F, LYS367D, LYS367F, LYS368D, LYS368F, MET298D, MET298F, PHE12D, PHE12F, PHE321D, PHE321F, PHE362D, PHE362F, PHE363D, PHE363F, PRO14D, PRO14F, PRO180D, PRO180F, PRO270D, PRO270F, PRO306D, PRO306F, PRO308D, PRO308F, SER10D, SER10F, SER1D, SER1F, SER283D, SER283F, SER301D, SER301F, SER314D, SER314F, SER355D, SER355F, SER365D, SER365F, THR296D, THR296F, THR309D, THR309F, THR8D, THR8F, TYR304D, TYR304F, TYR345D, TYR345F, VAL15D, VAL15F, VAL245D, VAL245F, VAL267D, VAL267F, VAL274D, VAL274F, VAL275D, VAL275F, VAL276D, VAL276F, VAL287D, VAL287F, VAL313D, VAL313F, VAL316D, VAL316F, VAL361D, VAL361F
• E-G: ALA261E, ALA261G, ALA271E, ALA271G, ALA277E, ALA277G, ALA288E, ALA288G, ALA295E, ALA295G, ALA311E, ALA311G, ALA317E, ALA317G, ALA319E, ALA319G, ALA353E, ALA353G, ALA356E, ALA356G, ALA4E, ALA4G, ARG262E, ARG262G, ARG307E, ARG307G, ARG310E, ARG310G, ARG348E, ARG348G, ASN167E, ASN167G, ASN241E, ASN241G, ASN247G, ASN286E, ASN286G, ASN318E, ASN318G, ASN322E, ASN322G, ASN358G, ASN364E, ASN364G, ASN6E, ASN6G, ASP13E, ASP13G, ASP144E, ASP144G, ASP145E, ASP145G, ASP249E, ASP249G, ASP264E, ASP264G, ASP315E, ASP315G, CYS285E, CYS285G, CYS294E, CYS294G, CYS350E, CYS350G, GLN243E, GLN243G, GLN246E, GLN246G, GLN278E, GLN278G, GLN297E, GLN297G, GLN2E, GLN2G, GLN370E, GLN370G, GLU268E, GLU268G, GLU272E, GLU272G, GLU300E, GLU300G, GLU312E, GLU312G, GLU352E, GLU352G, GLY146E, GLY146G, GLY181E, GLY263E, GLY263G, GLY266E, GLY266G, GLY323E, GLY323G, HIS169E, HIS242E, HIS242G, HIS5E, HIS5G, ILE11E, ILE11G, ILE147E, ILE147G, ILE149E, ILE149G, ILE248E, ILE269E, ILE269G, ILE280E, ILE280G, ILE282E, ILE282G, ILE349E, ILE349G, ILE366E, ILE366G, LEU148E, LEU148G, LEU265E, LEU265G, LEU281E, LEU281G, LEU299E, LEU299G, LEU351E, LEU351G, LEU357E, LEU357G, LEU369E, LEU369G, LEU3E, LEU3G, LEU7E, LEU7G, LEU9E, LEU9G, LYS273E, LYS273G, LYS279E, LYS279G, LYS284E, LYS284G, LYS367E, LYS367G, LYS368E, LYS368G, MET298E, MET298G, PHE12E, PHE12G, PHE321E, PHE321G, PHE362E, PHE362G, PHE363E, PHE363G, PRO14E, PRO14G, PRO180E, PRO270E, PRO270G, PRO306E, PRO306G, PRO308E, PRO308G, SER10E, SER10G, SER1E, SER1G, SER283E, SER283G, SER301E, SER301G, SER314E, SER314G, SER355E, SER355G, SER365E, SER365G, THR296E, THR296G, THR309E, THR309G, THR8E, THR8G, TYR304E, TYR304G, TYR345E, TYR345G, VAL15E, VAL15G, VAL245E, VAL245G, VAL267E, VAL267G, VAL274E, VAL274G, VAL275E, VAL275G, VAL276E, VAL276G, VAL287E, VAL287G, VAL313E, VAL313G, VAL316E, VAL316G, VAL361E, VAL361G
• F-G: ALA376F, ALA376G, ALA379F, ALA379G, ALA384F, ALA384G, ALA393F, ALA393G, ALA481F, ALA481G, ALA489F, ALA489G, ARG493F, ARG493G, ASN364F, ASN364G, ASN386F, ASN386G, ASN490F, ASN490G, ASP377F, ASP377G, ASP482F, ASP482G, CYS381F, CYS381G, GLN370F, GLN370G, GLN491F, GLN491G, GLU378F, GLU378G, GLU390F, GLU390G, GLU454F, GLU454G, GLU498F, GLU498G, GLY452F, GLY452G, HIS371F, HIS371G, HIS480F, HIS480G, HIS483F, HIS483G, ILE372F, ILE372G, ILE494F, ILE494G, LEU495F, LEU495G, LEU496F, LEU496G, LYS367F, LYS367G, LYS368F, LYS368G, LYS392F, LYS392G, LYS394G, LYS484F, LYS484G, MET374F, MET374G, PHE363F, PHE363G, PRO373F, PRO373G, SER375F, SER375G, SER382F, SER382G, SER383F, SER383G, SER387F, SER387G, THR391F, THR391G, THR492F, THR492G, TYR360F, TYR360G, TYR389F, TYR389G, TYR412F, TYR412G, TYR475F, TYR475G, TYR488F, TYR488G, VAL380F, VAL380G, VAL385F, VAL385G, VAL388F, VAL388G, VAL477F, VAL477G, VAL478F, VAL485F, VAL485G
• H-I: ALA376H, ALA376I, ALA379H, ALA379I, ALA384H, ALA384I, ALA393H, ALA393I, ALA481H, ALA481I, ALA489H, ALA489I, ARG493H, ARG493I, ASN364H, ASN364I, ASN386H, ASN386I, ASN415H, ASN490H, ASN490I, ASP377H, ASP377I, ASP482H, ASP482I, CYS381H, CYS381I, GLN370H, GLN370I, GLN491H, GLN491I, GLU378H, GLU378I, GLU390H, GLU390I, GLU454H, GLU454I, GLU498H, GLU498I, GLY452H, GLY452I, HIS371H, HIS371I, HIS480H, HIS480I, HIS483H, HIS483I, ILE372H, ILE372I, ILE494H, ILE494I, LEU495H, LEU495I, LEU496H, LEU496I, LYS367H, LYS367I, LYS368H, LYS368I, LYS392H, LYS392I, LYS484H, LYS484I, MET374H, MET374I, PHE363H, PHE363I, PRO373H, PRO373I, SER375H, SER375I, SER382H, SER382I, SER383H, SER383I, SER387H, SER387I, THR391H, THR391I, THR492H, THR492I, TYR360H, TYR360I, TYR389H, TYR389I, TYR412H, TYR412I, TYR475H, TYR475I, TYR488H, TYR488I, VAL380H, VAL380I, VAL385H, VAL385I, VAL388H, VAL388I, VAL477H, VAL477I, VAL485H, VAL485I
• H-J: ALA261H, ALA261J, ALA271H, ALA271J, ALA277H, ALA277J, ALA288H, ALA288J, ALA295H, ALA295J, ALA311H, ALA311J, ALA317H, ALA317J, ALA319H, ALA319J, ALA347J, ALA353H, ALA353J, ALA356H, ALA356J, ALA4H, ALA4J, ARG262H, ARG262J, ARG307H, ARG307J, ARG310H, ARG310J, ARG348H, ARG348J, ASN167H, ASN167J, ASN241H, ASN241J, ASN286H, ASN286J, ASN305H, ASN305J, ASN318H, ASN318J, ASN322H, ASN322J, ASN358H, ASN358J, ASN364H, ASN364J, ASN6H, ASN6J, ASP13H, ASP13J, ASP144H, ASP144J, ASP145H, ASP145J, ASP249H, ASP249J, ASP264H, ASP264J, ASP315H, ASP315J, CYS285H, CYS285J, CYS294H, CYS294J, CYS350H, CYS350J, GLN243H, GLN243J, GLN246H, GLN246J, GLN278H, GLN278J, GLN297H, GLN297J, GLN2H, GLN2J, GLN354H, GLN370H, GLN370J, GLU268H, GLU268J, GLU272H, GLU272J, GLU300H, GLU300J, GLU312H, GLU312J, GLU332J, GLU352H, GLU352J, GLY146H, GLY146J, GLY181H, GLY181J, GLY263H, GLY263J, GLY266H, GLY266J, GLY323H, GLY323J, HIS169H, HIS169J, HIS242H, HIS242J, HIS5H, HIS5J, ILE11H, ILE11J, ILE147H, ILE147J, ILE239H, ILE239J, ILE269H, ILE269J, ILE280H, ILE280J, ILE282H, ILE282J, ILE349H, ILE349J, ILE366H, ILE366J, LEU265H, LEU265J, LEU281H, LEU281J, LEU299H, LEU299J, LEU351H, LEU351J, LEU357H, LEU357J, LEU369H, LEU369J, LEU3H, LEU3J, LEU7H, LEU7J, LEU9H, LEU9J, LYS273H, LYS273J, LYS279H, LYS279J, LYS284H, LYS284J, LYS367H, LYS367J, LYS368H, LYS368J, MET298H, MET298J, MET302H, MET302J, MET346H, MET346J, PHE12H, PHE12J, PHE321H, PHE321J, PHE362H, PHE362J, PHE363H, PHE363J, PRO14H, PRO14J, PRO180H, PRO180J, PRO270H, PRO270J, PRO306H, PRO306J, PRO308H, PRO308J, SER10H, SER10J, SER1H, SER1J, SER283H, SER283J, SER301H, SER301J, SER314H, SER314J, SER355H, SER355J, SER365H, SER365J, THR296H, THR296J, THR309H, THR309J, THR8H, THR8J, TYR304H, TYR304J, TYR345H, TYR345J, VAL15H, VAL15J, VAL245H, VAL245J, VAL267H, VAL267J, VAL274H, VAL274J, VAL275H, VAL275J, VAL276H, VAL276J, VAL287H, VAL287J, VAL313H, VAL313J, VAL316H, VAL316J, VAL361H, VAL361J
• H-M: ALA191M, ARG194M, ASP193M, ASP196M, ASP474H, GLN198M, GLN471H, GLU498H, GLU58M, GLY473H, HIS57M, LEU197M, LEU495H, LEU496H, LYS192M, LYS394H, PHE199M, SER190M, SER56M, THR472H, TYR475H, VAL195M, VAL497H
• I-L: ARG136L, ASP157I
• I-M: ALA481I, ALA481M, ALA489I, ALA489M, ARG231I, ARG231M, ARG404I, ARG404M, ARG424I, ARG424M, ARG456I, ARG456M, ASN401I, ASN401M, ASP232I, ASP232M, ASP377I, ASP377M, ASP445I, ASP445M, GLN198I, GLN198M, GLN203I, GLN203M, GLU202I, GLU202M, GLU253I, GLU253M, GLY204I, GLY204M, GLY227I, GLY227M, GLY230I, GLY230M, GLY487I, GLY487M, LEU226I, LEU226M, LYS224I, LYS224M, LYS229I, LYS229M, LYS453I, LYS453M, LYS484I, LYS484M, LYS486I, LYS486M, PHE199I, PHE199M, PRO228I, PRO228M, SER400I, SER400M, SER405I, THR402I, THR402M, THR423I, TYR488I, TYR488M, VAL201I, VAL201M, VAL485I, VAL485M
• I-N: ASP196I, GLU498N, GLU58I, HIS57I, LYS192I
• J-M: ARG136J, GLU156M
• K-L: ALA376K, ALA376L, ALA379K, ALA379L, ALA384K, ALA384L, ALA393K, ALA393L, ALA481K, ALA481L, ALA489K, ALA489L, ARG493K, ARG493L, ASN364K, ASN364L, ASN386K, ASN386L, ASN415K, ASN490K, ASN490L, ASP377K, ASP377L, ASP482K, ASP482L, CYS381K, CYS381L, GLN370K, GLN370L, GLN491K, GLN491L, GLU378K, GLU378L, GLU390K, GLU390L, GLU454K, GLU454L, GLU498K, GLU498L, GLY452K, GLY452L, HIS371K, HIS371L, HIS480K, HIS480L, HIS483K, HIS483L, ILE372K, ILE372L, ILE494K, ILE494L, LEU495K, LEU495L, LEU496K, LEU496L, LYS367K, LYS367L, LYS368K, LYS368L, LYS392K, LYS392L, LYS394K, LYS484K, LYS484L, MET374K, MET374L, PHE363K, PHE363L, PRO373K, PRO373L, SER375K, SER375L, SER382K, SER382L, SER383K, SER383L, SER387K, SER387L, THR391K, THR391L, THR492K, THR492L, TYR360K, TYR360L, TYR389K, TYR389L, TYR412K, TYR412L, TYR475K, TYR475L, TYR488K, TYR488L, VAL380K, VAL380L, VAL385K, VAL385L, VAL388K, VAL388L, VAL477K, VAL477L, VAL478K, VAL485K, VAL485L
• K-M: ALA261K, ALA261M, ALA271K, ALA271M, ALA277K, ALA277M, ALA288K, ALA288M, ALA295K, ALA295M, ALA311K, ALA311M, ALA317K, ALA317M, ALA319K, ALA319M, ALA353K, ALA353M, ALA356K, ALA356M, ALA4K, ALA4M, ARG262K, ARG262M, ARG307K, ARG307M, ARG310K, ARG310M, ARG348K, ARG348M, ASN167K, ASN167M, ASN241K, ASN241M, ASN286K, ASN286M, ASN305K, ASN318K, ASN318M, ASN322K, ASN322M, ASN358K, ASN358M, ASN364K, ASN364M, ASN6K, ASN6M, ASP13K, ASP13M, ASP144K, ASP144M, ASP145K, ASP145M, ASP249K, ASP249M, ASP264K, ASP264M, ASP315K, ASP315M, CYS285K, CYS285M, CYS294K, CYS294M, CYS350K, CYS350M, GLN243K, GLN243M, GLN246K, GLN246M, GLN278K, GLN278M, GLN297K, GLN297M, GLN2K, GLN2M, GLN354M, GLN370K, GLN370M, GLU268K, GLU268M, GLU272K, GLU272M, GLU300K, GLU300M, GLU312K, GLU312M, GLU352K, GLU352M, GLY146K, GLY146M, GLY181K, GLY181M, GLY263K, GLY263M, GLY266K, GLY266M, GLY323K, GLY323M, HIS169K, HIS169M, HIS242K, HIS242M, HIS5K, HIS5M, ILE11K, ILE11M, ILE147K, ILE147M, ILE149K, ILE149M, ILE239K, ILE239M, ILE248K, ILE269K, ILE269M, ILE280K, ILE280M, ILE282K, ILE282M, ILE349K, ILE349M, ILE366K, ILE366M, LEU148K, LEU148M, LEU265K, LEU265M, LEU281K, LEU281M, LEU299K, LEU299M, LEU351K, LEU351M, LEU357K, LEU357M, LEU369K, LEU369M, LEU3K, LEU3M, LEU7K, LEU7M, LEU9K, LEU9M, LYS273K, LYS273M, LYS279K, LYS279M, LYS284K, LYS284M, LYS367K, LYS367M, LYS368K, LYS368M, MET298K, MET298M, MET302K, PHE12K, PHE12M, PHE321K, PHE321M, PHE362K, PHE362M, PHE363K, PHE363M, PRO14K, PRO14M, PRO180K, PRO180M, PRO270K, PRO270M, PRO306K, PRO306M, PRO308K, PRO308M, SER10K, SER10M, SER1K, SER1M, SER283K, SER283M, SER301K, SER301M, SER314K, SER314M, SER355K, SER355M, SER365K, SER365M, THR296K, THR296M, THR309K, THR309M, THR8K, THR8M, TYR304K, TYR304M, TYR345K, TYR345M, VAL15K, VAL15M, VAL245K, VAL245M, VAL267K, VAL267M, VAL274K, VAL274M, VAL275K, VAL275M, VAL276K, VAL276M, VAL287K, VAL287M, VAL313K, VAL313M, VAL316K, VAL316M, VAL320K, VAL320M, VAL361K, VAL361M
• K-S: ASP196S, GLU498K, GLU58S, HIS57S, LYS192S
• L-N: ALA271L, ALA277L, ALA288L, ALA4N, ARG262L, ARG262N, ARG307L, ARG307N, ARG310L, ARG310N, ARG348L, ARG348N, ASN241L, ASN286L, ASN322L, ASN364L, ASN6L, ASN6N, ASP13L, ASP13N, ASP145L, ASP145N, ASP249L, ASP315L, ASP315N, CYS182L, CYS285L, GLN243L, GLN246L, GLN278L, GLN297L, GLN297N, GLN2L, GLN2N, GLN370L, GLU268L, GLU272L, GLU272N, GLU300L, GLU300N, GLU312L, GLU312N, GLU352L, GLU352N, GLY181L, GLY263L, GLY323L, HIS242L, HIS5L, HIS5N, ILE11N, ILE248L, ILE252L, ILE269L, ILE280L, ILE282L, ILE366L, LEU265L, LEU281L, LEU369L, LEU3N, LEU7N, LEU9N, LYS273L, LYS273N, LYS279L, LYS279N, LYS284L, LYS367L, LYS368L, PHE12N, PHE321L, PHE362L, PRO14N, PRO180L, PRO270L, SER10N, SER1N, SER283L, SER283N, SER365L, THR8N, VAL15N, VAL245L, VAL274L, VAL275L, VAL276L, VAL287L, VAL361L
• L-O: ARG103O, ASP157O, ASP98L, GLU156O, GLU158O, HIS155O, LYS335L, LYS337L
• L-S: ARG231L, ARG231S, ASP445L, ASP445S, GLN198L, GLN198S, GLU202L, GLU202S, LYS229L, LYS229S, LYS484L, LYS484S, LYS486L, LYS486S
• L-T: ASP196L, GLU498T, HIS57L, LYS192L
• M-N: ARG493M, ARG493N, ASP482M, ASP482N, GLU378M, GLU378N, GLU390M, GLU390N, GLU454M, GLU454N, HIS483M, HIS483N, LYS367M, LYS367N, LYS484M, LYS484N
• N-O: ARG136O, ASN305N, ASP183O, ASP249O, GLU58N, LYS335N
• N-P: ASP13P, GLU35N
• O-P: ARG262O, ARG262P, ARG307O, ARG307P, ARG310O, ARG310P, ARG348O, ARG348P, ASP13O, ASP13P, ASP145O, ASP145P, ASP315O, ASP315P, GLN297O, GLN297P, GLU272O, GLU272P, GLU300O, GLU300P, GLU312O, GLU312P, GLU352O, GLU352P, HIS5O, HIS5P, LYS273O, LYS273P, LYS279O, LYS279P
• P-U: ASP196P, GLU498U, GLU58P, HIS57P, LYS192P
• P-V: ARG231P, ARG231V, ARG404P, ASP232V, ASP445P, ASP445V, GLN198P, GLU202P, GLU202V, LYS229P, LYS229V, LYS484P, LYS484V, LYS486P, LYS486V
• Q-R: ARG493Q, ARG493R, ASP482Q, ASP482R, GLU378Q, GLU378R, GLU390Q, GLU390R, GLU454Q, GLU454R, HIS483Q, HIS483R, LYS367Q, LYS367R, LYS484Q, LYS484R, MET374Q
• Q-S: ARG262Q, ARG262S, ARG307Q, ARG307S, ARG310Q, ARG310S, ARG348Q, ARG348S, ASN6Q, ASP13Q, ASP13S, ASP145Q, ASP145S, ASP315Q, ASP315S, GLN297S, GLU272Q, GLU272S, GLU300Q, GLU300S, GLU312Q, GLU312S, GLU352Q, GLU352S, HIS5Q, HIS5S, LYS273Q, LYS273S, LYS279Q, LYS279S, SER283S
• R-T: ARG262R, ARG262T, ARG307T, ARG310R, ARG310T, ARG348R, ARG348T, ASN6R, ASP13R, ASP13T, ASP145R, ASP315R, ASP315T, GLU272R, GLU272T, GLU300R, GLU300T, GLU312R, GLU312T, GLU352R, GLU352T, HIS5R, HIS5T, ILE11T, LYS273R, LYS273T, LYS279R, LYS279T, SER283T
• S-T: ARG493S, ARG493T, ASP482S, ASP482T, GLN491S, GLN491T, GLU378S, GLU378T, GLU390S, GLU390T, GLU454S, GLU454T, HIS480S, HIS483S, HIS483T, LYS367S, LYS484S, LYS484T
• U-V: ARG493U, ARG493V, ASP482U, ASP482V, GLU378U, GLU378V, GLU390U, GLU390V, GLU454U, GLU454V, HIS483U, HIS483V, LYS367U, LYS367V, LYS484U, LYS484V, MET374V
• U-W: ALA311W, ARG262U, ARG262W, ARG307U, ARG307W, ARG310U, ARG310W, ARG348U, ARG348W, ASP13U, ASP13W, ASP145U, ASP145W, ASP315U, ASP315W, GLN297U, GLN297W, GLU272U, GLU272W, GLU300U, GLU300W, GLU312U, GLU312W, GLU352U, GLU352W, GLY263U, HIS5U, HIS5W, LYS273U, LYS273W, LYS279U, LYS279W
• V-X: ARG262V, ARG262X, ARG307V, ARG307X, ARG310V, ARG310X, ARG348V, ARG348X, ASN6V, ASN6X, ASP13V, ASP13X, ASP145V, ASP145X, ASP315V, ASP315X, GLN297V, GLU272V, GLU272X, GLU300V, GLU300X, GLU312V, GLU312X, GLU352V, GLU352X, HIS5V, HIS5X, LYS273V, LYS273X, LYS279V, LYS279X, SER283X
• W-X: ARG493W, ARG493X, ASP482W, ASP482X, GLU378W, GLU378X, GLU390W, GLU390X, GLU454W, GLU454X, HIS483W, HIS483X, LYS367W, LYS367X, LYS484W, LYS484X, MET374X