3HQP

crystal structure of leishmania mexicana pyruvate kinase (lmpyk) in complex with atp, oxalate and fructose 2,6 bisphosphate

• Total interactions analyzed: 120
• Total true interactions: 27
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 29
  • Norm. En. per Res.: -4.9028
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-110.4633	-40.8815	-298.939	-450.2838	108	18	8	12213	5	39	41
A-C	-93.6728	-23.3728	-689.878	-806.9236	252	34	31	31830	4	59	50
A-M	0.0	0.0	-3.6014	-3.6014	17	0	0	335	0	7	4
A-O	0.0	44.9408			7
B-D	-92.1715	-26.9688	-667.123	-786.2632	253	34	31	31791	4	59	50
C-D	-115.8594	-36.7666	-308.34	-460.9661	107	15	9	12475	5	39	40
C-G	0.0	-7.1747	-13.9148	-21.0895	13	1	0	565	1	12	10
C-I	0.0	-4.9245	-35.0382	-39.9627	24	1	1	1767	1	9	11
D-I	-20.8018	20.8321	-109.412	-109.3817	67	5	0	4859	7	38	46
D-J	0.0	-7.1219	-36.2685	-43.3904	23	0	1	1785	1	9	11
D-N	0.0	37.5377	0.0	37.5377	4	0	0	0	0	1	0
E-F	-94.88	-30.8735	-311.968	-437.7215	107	18	9	12469	5	42	41
E-G	-82.9202	-22.0916	-660.797	-765.8088	254	23	32	31060	2	60	51
E-I	0.0	0.0	-0.4291	-0.4291	10	0	0	127	0	5	4
E-K	-5.207	0.0	-23.6978	-28.9048	20	4	0	1163	0	5	7
F-H	-78.7265	-10.2904	-696.784	-785.8009	254	29	31	32466	3	62	50
G-H	-96.4624	-52.7605	-317.135	-466.3578	111	15	8	12884	4	39	42
I-J	-96.3114	-33.8704	-313.689	-443.8708	108	12	8	12903	4	40	41
I-K	-96.0073	-18.6444	-678.324	-792.9757	254	42	32	32116	3	60	51
I-N	0.0	-2.4425	0.0	-2.4425	2	0	0	0	0	0	0
J-L	-97.8726	-26.7605	-670.08	-794.7131	256	35	31	31711	4	61	50
K-L	-90.8031	-40.2897	-316.337	-447.4298	108	15	8	12701	5	40	42
K-P	0.0	4.0208			2
M-N	-95.2062	-46.9742	0.0	-142.1803	29	0	0	0	0	0	0
M-O	-52.2232	-36.3438			32
N-P	-86.9591	-11.1113			39
O-P	-89.8137	-51.9423			31

Interface residues

• A-B: ALA376A, ALA376B, ALA379A, ALA379B, ALA384A, ALA384B, ALA393A, ALA393B, ALA481A, ALA481B, ALA489A, ALA489B, ARG493A, ARG493B, ASN364A, ASN364B, ASN386A, ASN386B, ASN490A, ASN490B, ASP377A, ASP377B, ASP482A, ASP482B, CYS381A, CYS381B, CYS476A, CYS476B, GLN370A, GLN370B, GLN491A, GLN491B, GLU378A, GLU378B, GLU390A, GLU390B, GLU454A, GLU454B, GLU498A, GLU498B, GLY452B, HIS371A, HIS371B, HIS480A, HIS480B, HIS483A, HIS483B, ILE372A, ILE372B, ILE479B, ILE494A, ILE494B, LEU495A, LEU495B, LEU496A, LEU496B, LYS367A, LYS367B, LYS368A, LYS368B, LYS392A, LYS392B, LYS394A, LYS484A, LYS484B, MET374A, MET374B, PHE363A, PHE363B, PRO373A, PRO373B, SER375A, SER375B, SER382A, SER382B, SER383A, SER383B, SER387A, SER387B, THR391A, THR391B, THR492A, THR492B, TYR360A, TYR360B, TYR389A, TYR389B, TYR412A, TYR412B, TYR475A, TYR475B, TYR488A, TYR488B, VAL380A, VAL380B, VAL385A, VAL385B, VAL388A, VAL388B, VAL457B, VAL477A, VAL477B, VAL478A, VAL478B, VAL485A, VAL485B, VAL497A, VAL497B
• A-C: ALA261A, ALA261C, ALA271A, ALA271C, ALA277A, ALA277C, ALA288A, ALA288C, ALA295A, ALA295C, ALA311A, ALA311C, ALA317A, ALA317C, ALA319A, ALA319C, ALA347A, ALA347C, ALA353A, ALA353C, ALA356A, ALA356C, ALA4A, ALA4C, ARG103A, ARG103C, ARG262A, ARG262C, ARG307A, ARG307C, ARG310A, ARG310C, ARG348A, ARG348C, ARG413A, ARG413C, ASN167A, ASN167C, ASN178A, ASN178C, ASN241A, ASN241C, ASN247A, ASN286A, ASN286C, ASN305A, ASN305C, ASN318A, ASN318C, ASN322A, ASN322C, ASN358A, ASN358C, ASN364A, ASN364C, ASN6A, ASN6C, ASP13A, ASP13C, ASP144A, ASP144C, ASP145A, ASP145C, ASP249A, ASP249C, ASP264A, ASP264C, ASP315A, ASP315C, CYS285A, CYS285C, CYS294A, CYS294C, CYS350A, CYS350C, GLN243A, GLN243C, GLN246A, GLN246C, GLN278A, GLN278C, GLN297A, GLN297C, GLN2A, GLN2C, GLN354C, GLN370A, GLN370C, GLU268A, GLU268C, GLU272A, GLU272C, GLU300A, GLU300C, GLU312A, GLU312C, GLU341A, GLU341C, GLU352A, GLU352C, GLY146A, GLY146C, GLY244A, GLY263A, GLY263C, GLY266A, GLY266C, GLY323A, GLY323C, HIS169A, HIS169C, HIS242A, HIS242C, HIS5A, HIS5C, ILE11A, ILE11C, ILE141A, ILE141C, ILE143A, ILE143C, ILE147A, ILE147C, ILE149A, ILE149C, ILE239A, ILE252C, ILE269A, ILE269C, ILE280A, ILE280C, ILE282A, ILE282C, ILE349A, ILE349C, ILE366A, ILE366C, LEU148A, LEU148C, LEU150A, LEU150C, LEU265A, LEU265C, LEU281A, LEU281C, LEU299A, LEU299C, LEU351A, LEU351C, LEU357A, LEU357C, LEU369A, LEU369C, LEU3A, LEU3C, LEU7A, LEU7C, LEU9A, LEU9C, LYS273A, LYS273C, LYS279A, LYS279C, LYS284A, LYS284C, LYS337A, LYS337C, LYS367A, LYS367C, LYS368A, LYS368C, LYS411A, LYS411C, MET298A, MET298C, MET346A, MET346C, PHE12A, PHE12C, PHE321A, PHE321C, PHE362A, PHE362C, PHE363A, PHE363C, PRO14A, PRO14C, PRO270A, PRO270C, PRO306A, PRO306C, PRO308A, PRO308C, SER10A, SER10C, SER168A, SER168C, SER1A, SER1C, SER283A, SER283C, SER301A, SER301C, SER314A, SER314C, SER355A, SER355C, SER365A, SER365C, THR166A, THR166C, THR170A, THR170C, THR296A, THR296C, THR309A, THR309C, THR8A, THR8C, TYR140A, TYR140C, TYR142A, TYR142C, TYR304A, TYR304C, TYR338A, TYR338C, TYR345A, TYR345C, VAL15A, VAL15C, VAL245A, VAL245C, VAL260C, VAL267A, VAL267C, VAL274A, VAL274C, VAL275A, VAL275C, VAL276A, VAL276C, VAL287A, VAL287C, VAL313A, VAL313C, VAL316A, VAL316C, VAL320A, VAL320C, VAL361A, VAL361C
• A-M: ALA191A, ARG194A, ARG231A, ASP13M, ASP474M, GLN198A, GLN471M, GLY227A, GLY473M, LYS229A, LYS394M, PHE12M, PRO14M, PRO228A, SER10M, THR472M, VAL195A
• A-O: ASP112A, ASP117A, ASP185O, ASP221O, GLU158A, GLU217O, LYS224O
• B-D: ALA261B, ALA261D, ALA271B, ALA271D, ALA277B, ALA277D, ALA288B, ALA288D, ALA295B, ALA295D, ALA311B, ALA311D, ALA317B, ALA317D, ALA319B, ALA319D, ALA347B, ALA347D, ALA353B, ALA353D, ALA356B, ALA356D, ALA4B, ALA4D, ARG103B, ARG103D, ARG262B, ARG262D, ARG307B, ARG307D, ARG310B, ARG310D, ARG348B, ARG348D, ARG413B, ARG413D, ASN167B, ASN167D, ASN178B, ASN178D, ASN241B, ASN241D, ASN247D, ASN286B, ASN286D, ASN305B, ASN305D, ASN318B, ASN318D, ASN322B, ASN322D, ASN358B, ASN358D, ASN364B, ASN364D, ASN6B, ASN6D, ASP13B, ASP13D, ASP144B, ASP144D, ASP145B, ASP145D, ASP249B, ASP249D, ASP264B, ASP264D, ASP315B, ASP315D, CYS285B, CYS285D, CYS294B, CYS294D, CYS350B, CYS350D, GLN243B, GLN243D, GLN246B, GLN246D, GLN278B, GLN278D, GLN297B, GLN297D, GLN2B, GLN2D, GLN354B, GLN354D, GLN370B, GLN370D, GLU268B, GLU268D, GLU272B, GLU272D, GLU300B, GLU300D, GLU312B, GLU312D, GLU341B, GLU341D, GLU352B, GLU352D, GLY146B, GLY146D, GLY263B, GLY263D, GLY266B, GLY266D, GLY323B, GLY323D, HIS169B, HIS169D, HIS242B, HIS242D, HIS5B, HIS5D, ILE11B, ILE11D, ILE141B, ILE141D, ILE143B, ILE143D, ILE147B, ILE147D, ILE149B, ILE149D, ILE239D, ILE252B, ILE252D, ILE269B, ILE269D, ILE280B, ILE280D, ILE282B, ILE282D, ILE349B, ILE349D, ILE366B, ILE366D, LEU148B, LEU148D, LEU150B, LEU150D, LEU265B, LEU265D, LEU281B, LEU281D, LEU299B, LEU299D, LEU351B, LEU351D, LEU357B, LEU357D, LEU369B, LEU369D, LEU3B, LEU3D, LEU7B, LEU7D, LEU9B, LEU9D, LYS273B, LYS273D, LYS279B, LYS279D, LYS284B, LYS284D, LYS337B, LYS337D, LYS367B, LYS367D, LYS368B, LYS368D, LYS411B, LYS411D, MET298B, MET298D, MET346B, PHE12B, PHE12D, PHE321B, PHE321D, PHE362B, PHE362D, PHE363B, PHE363D, PRO14B, PRO14D, PRO270B, PRO270D, PRO306B, PRO306D, PRO308B, PRO308D, SER10B, SER10D, SER168B, SER168D, SER1B, SER1D, SER283B, SER283D, SER301B, SER301D, SER314B, SER314D, SER355B, SER355D, SER365B, SER365D, THR166B, THR166D, THR170B, THR170D, THR296B, THR296D, THR309B, THR309D, THR8B, THR8D, TYR140B, TYR140D, TYR142B, TYR142D, TYR304B, TYR304D, TYR338B, TYR338D, TYR345B, TYR345D, VAL15B, VAL15D, VAL245B, VAL245D, VAL260B, VAL260D, VAL267B, VAL267D, VAL274B, VAL274D, VAL275B, VAL275D, VAL276B, VAL276D, VAL287B, VAL287D, VAL313B, VAL313D, VAL316B, VAL316D, VAL320B, VAL320D, VAL361B, VAL361D
• C-D: ALA376C, ALA376D, ALA379C, ALA379D, ALA384C, ALA384D, ALA393C, ALA393D, ALA481C, ALA481D, ALA489C, ALA489D, ARG493C, ARG493D, ASN364C, ASN364D, ASN386C, ASN386D, ASN490C, ASN490D, ASP377C, ASP377D, ASP482C, ASP482D, CYS381C, CYS381D, CYS476C, CYS476D, GLN370C, GLN370D, GLN491C, GLN491D, GLU378C, GLU378D, GLU390C, GLU390D, GLU454C, GLU454D, GLU498C, GLU498D, HIS371C, HIS371D, HIS480C, HIS480D, HIS483C, HIS483D, ILE372C, ILE372D, ILE494C, ILE494D, LEU495C, LEU495D, LEU496C, LEU496D, LYS367C, LYS367D, LYS368C, LYS368D, LYS392C, LYS392D, LYS453C, LYS484C, LYS484D, MET374C, MET374D, PHE363C, PHE363D, PRO373C, PRO373D, SER375C, SER375D, SER382C, SER382D, SER383C, SER383D, SER387C, SER387D, THR391C, THR391D, THR492C, THR492D, TYR360C, TYR360D, TYR389C, TYR389D, TYR412C, TYR412D, TYR475C, TYR475D, TYR488C, TYR488D, VAL380C, VAL380D, VAL385C, VAL385D, VAL388C, VAL388D, VAL457C, VAL457D, VAL477C, VAL477D, VAL478C, VAL478D, VAL485C, VAL485D, VAL497C, VAL497D
• C-G: ALA444C, ARG136G, ASP443C, ASP445C, GLY448C, HIS155G, LEU447C, LYS133G, LYS446C, PRO137G, SER132G, VAL134G, VAL135G
• C-I: ALA191I, ARG194I, ASP193I, ASP196I, ASP474C, GLN198I, GLN471C, GLU202I, GLU498C, GLU58I, GLY473C, HIS57I, LEU197I, LEU496C, LYS192I, LYS465C, LYS85I, PHE199I, SER190I, SER56I, THR472C, TYR475C, VAL195I, VAL497C
• D-I: ALA225D, ARG231D, ARG231I, ARG404D, ARG404I, ARG424D, ARG424I, ARG456I, ASN401D, ASN401I, ASN490I, ASP232D, ASP232I, ASP377D, ASP377I, ASP445D, ASP445I, ASP482I, GLN198D, GLN198I, GLN203D, GLN203I, GLU202D, GLU202I, GLU253D, GLU253I, GLY204D, GLY204I, GLY227D, GLY227I, GLY230D, GLY230I, GLY487D, GLY487I, HIS449D, HIS449I, HIS483I, HIS57D, HIS57I, ILE233D, ILE233I, LEU226D, LEU226I, LYS224D, LYS224I, LYS229D, LYS229I, LYS453I, LYS484D, LYS484I, LYS486D, LYS486I, PHE199D, PHE199I, PRO228D, PRO228I, SER375D, THR402D, THR402I, TYR488D, TYR488I, VAL195D, VAL195I, VAL201D, VAL201I, VAL485D, VAL485I
• D-J: ALA191D, ARG194D, ASP193D, ASP196D, ASP474J, GLN198D, GLN471J, GLU202D, GLU498J, GLU58D, GLY473J, HIS57D, LEU197D, LEU496J, LYS192D, LYS465J, LYS85D, PHE199D, SER190D, THR472J, TYR475J, VAL195D, VAL497J
• D-N: ASP112N, ASP185D, GLU158N, GLU217D
• E-F: ALA376E, ALA376F, ALA379E, ALA379F, ALA384E, ALA384F, ALA393E, ALA393F, ALA481E, ALA481F, ALA489E, ALA489F, ARG493E, ARG493F, ASN364E, ASN364F, ASN386E, ASN386F, ASN415F, ASN490E, ASN490F, ASP377E, ASP377F, ASP482E, ASP482F, CYS381E, CYS381F, CYS476E, CYS476F, GLN370E, GLN370F, GLN491E, GLN491F, GLU378E, GLU378F, GLU390E, GLU390F, GLU454E, GLU454F, GLU498E, GLU498F, GLY452E, GLY452F, HIS371E, HIS371F, HIS480E, HIS480F, HIS483E, HIS483F, ILE372E, ILE372F, ILE494E, ILE494F, LEU495E, LEU495F, LEU496E, LEU496F, LYS367E, LYS367F, LYS368E, LYS368F, LYS392E, LYS392F, LYS484E, LYS484F, MET374E, MET374F, PHE363E, PHE363F, PRO373E, PRO373F, SER375E, SER375F, SER382E, SER382F, SER383E, SER383F, SER387E, SER387F, THR391E, THR391F, THR492E, THR492F, TYR360E, TYR360F, TYR389E, TYR389F, TYR412E, TYR412F, TYR475E, TYR475F, TYR488E, TYR488F, VAL380E, VAL380F, VAL385E, VAL385F, VAL388E, VAL388F, VAL477E, VAL477F, VAL478E, VAL478F, VAL485E, VAL485F, VAL497E, VAL497F
• E-G: ALA261E, ALA261G, ALA271E, ALA271G, ALA277E, ALA277G, ALA288E, ALA288G, ALA295E, ALA295G, ALA311E, ALA311G, ALA317E, ALA317G, ALA319E, ALA319G, ALA347E, ALA347G, ALA353E, ALA353G, ALA356E, ALA356G, ALA4E, ALA4G, ARG103E, ARG103G, ARG262E, ARG262G, ARG307E, ARG307G, ARG310E, ARG310G, ARG348E, ARG348G, ARG413E, ARG413G, ASN167E, ASN167G, ASN178E, ASN178G, ASN241E, ASN241G, ASN247E, ASN247G, ASN286E, ASN286G, ASN305E, ASN305G, ASN318E, ASN318G, ASN322E, ASN322G, ASN358E, ASN358G, ASN364E, ASN364G, ASN6E, ASN6G, ASP13E, ASP13G, ASP144E, ASP144G, ASP145E, ASP145G, ASP249E, ASP249G, ASP264E, ASP264G, ASP315E, ASP315G, CYS285E, CYS285G, CYS294E, CYS294G, CYS350E, CYS350G, GLN243E, GLN243G, GLN246E, GLN246G, GLN278E, GLN278G, GLN297E, GLN297G, GLN2E, GLN2G, GLN354E, GLN354G, GLN370E, GLN370G, GLU268E, GLU268G, GLU272E, GLU272G, GLU300E, GLU300G, GLU312E, GLU312G, GLU341E, GLU341G, GLU352E, GLU352G, GLY146E, GLY146G, GLY244E, GLY263E, GLY263G, GLY266E, GLY266G, GLY323E, GLY323G, HIS169E, HIS169G, HIS242E, HIS242G, HIS5E, HIS5G, ILE11E, ILE11G, ILE141E, ILE143E, ILE143G, ILE147E, ILE147G, ILE149E, ILE149G, ILE239E, ILE248E, ILE248G, ILE252E, ILE252G, ILE269E, ILE269G, ILE280E, ILE280G, ILE282E, ILE282G, ILE349E, ILE349G, ILE366E, ILE366G, LEU148E, LEU148G, LEU150E, LEU150G, LEU265E, LEU265G, LEU281E, LEU281G, LEU299E, LEU299G, LEU351E, LEU351G, LEU357E, LEU357G, LEU369E, LEU369G, LEU3E, LEU3G, LEU7E, LEU7G, LEU9E, LEU9G, LYS273E, LYS273G, LYS279E, LYS279G, LYS284E, LYS284G, LYS337E, LYS337G, LYS367E, LYS367G, LYS368E, LYS368G, LYS411E, LYS411G, MET298E, MET298G, MET346E, MET346G, PHE12E, PHE12G, PHE321E, PHE321G, PHE362E, PHE362G, PHE363E, PHE363G, PRO14E, PRO14G, PRO270E, PRO270G, PRO306E, PRO306G, PRO308E, PRO308G, SER10E, SER10G, SER168E, SER168G, SER1E, SER1G, SER283E, SER283G, SER301E, SER301G, SER314E, SER314G, SER355E, SER355G, SER365E, SER365G, THR166E, THR166G, THR170E, THR296E, THR296G, THR309E, THR309G, THR8E, THR8G, TYR140E, TYR140G, TYR142E, TYR142G, TYR304E, TYR304G, TYR338E, TYR338G, TYR345E, TYR345G, VAL15E, VAL15G, VAL245E, VAL245G, VAL267E, VAL267G, VAL274E, VAL274G, VAL275E, VAL275G, VAL276E, VAL276G, VAL287E, VAL287G, VAL313E, VAL313G, VAL316E, VAL316G, VAL320E, VAL320G, VAL361E, VAL361G
• E-I: GLN471E, GLU35I, GLU462E, GLU498E, GLU73I, LEU74I, LYS38I, LYS465E, SER466E, THR472E
• E-K: ALA444E, ARG136K, ASN139K, ASP443E, ASP445E, CYS163K, GLN151K, GLN153K, GLU162K, GLY138K, GLY448E, LEU447E, LYS446E, PHE441E, PRO137K, SER154K, THR164K, THR166K, TYR140K, VAL152K
• F-H: ALA261F, ALA261H, ALA271F, ALA271H, ALA277F, ALA277H, ALA288F, ALA288H, ALA295F, ALA295H, ALA311F, ALA311H, ALA317F, ALA317H, ALA319F, ALA319H, ALA347F, ALA347H, ALA353F, ALA353H, ALA356F, ALA356H, ALA4F, ALA4H, ARG103F, ARG103H, ARG262F, ARG262H, ARG307F, ARG307H, ARG310F, ARG310H, ARG348F, ARG348H, ARG413F, ARG413H, ASN167F, ASN167H, ASN178F, ASN178H, ASN241F, ASN241H, ASN247F, ASN247H, ASN286F, ASN286H, ASN305F, ASN305H, ASN318F, ASN318H, ASN322F, ASN322H, ASN358F, ASN358H, ASN364F, ASN364H, ASN6F, ASN6H, ASP13F, ASP13H, ASP144F, ASP144H, ASP145F, ASP145H, ASP249F, ASP249H, ASP264F, ASP264H, ASP315F, ASP315H, CYS285F, CYS285H, CYS294F, CYS294H, CYS350F, CYS350H, GLN243F, GLN243H, GLN246F, GLN246H, GLN278F, GLN278H, GLN297F, GLN297H, GLN2F, GLN2H, GLN354F, GLN354H, GLN370F, GLN370H, GLU268F, GLU268H, GLU272F, GLU272H, GLU300F, GLU300H, GLU312F, GLU312H, GLU341F, GLU341H, GLU352F, GLU352H, GLY146F, GLY146H, GLY244F, GLY244H, GLY263F, GLY263H, GLY266F, GLY266H, GLY323F, GLY323H, HIS169F, HIS169H, HIS242F, HIS242H, HIS5F, HIS5H, ILE11F, ILE11H, ILE143F, ILE143H, ILE147F, ILE147H, ILE149F, ILE149H, ILE248F, ILE248H, ILE252F, ILE252H, ILE269F, ILE269H, ILE280F, ILE280H, ILE282F, ILE282H, ILE349F, ILE349H, ILE366F, ILE366H, LEU148F, LEU148H, LEU150F, LEU150H, LEU265F, LEU265H, LEU281F, LEU281H, LEU299F, LEU299H, LEU351F, LEU351H, LEU357F, LEU357H, LEU369F, LEU369H, LEU3F, LEU3H, LEU7F, LEU7H, LEU9F, LEU9H, LYS273F, LYS273H, LYS279F, LYS279H, LYS284F, LYS284H, LYS337F, LYS337H, LYS367F, LYS367H, LYS368F, LYS368H, LYS411F, LYS411H, MET298F, MET298H, PHE12F, PHE12H, PHE321F, PHE321H, PHE362F, PHE362H, PHE363F, PHE363H, PRO14F, PRO14H, PRO270F, PRO270H, PRO306F, PRO306H, PRO308F, PRO308H, SER10F, SER10H, SER168F, SER168H, SER1F, SER1H, SER283F, SER283H, SER301F, SER301H, SER314F, SER314H, SER355F, SER355H, SER365F, SER365H, THR166F, THR166H, THR170F, THR170H, THR296F, THR296H, THR309F, THR309H, THR8F, THR8H, TYR140F, TYR140H, TYR142F, TYR142H, TYR304F, TYR304H, TYR338F, TYR338H, TYR345F, TYR345H, VAL15F, VAL15H, VAL245F, VAL245H, VAL260F, VAL260H, VAL267F, VAL267H, VAL274F, VAL274H, VAL275F, VAL275H, VAL276F, VAL276H, VAL287F, VAL287H, VAL313F, VAL313H, VAL316F, VAL316H, VAL320F, VAL320H, VAL361F, VAL361H
• G-H: ALA376G, ALA376H, ALA379G, ALA379H, ALA384G, ALA384H, ALA393G, ALA393H, ALA481G, ALA481H, ALA489G, ALA489H, ARG493G, ARG493H, ASN364G, ASN364H, ASN386G, ASN386H, ASN415G, ASN415H, ASN490G, ASN490H, ASP377G, ASP377H, ASP482G, ASP482H, CYS381G, CYS381H, CYS476G, CYS476H, GLN370G, GLN370H, GLN491G, GLN491H, GLU378G, GLU378H, GLU390G, GLU390H, GLU454G, GLU454H, GLU498G, GLU498H, GLY452G, GLY452H, HIS371G, HIS371H, HIS480G, HIS480H, HIS483G, HIS483H, ILE372G, ILE372H, ILE494G, ILE494H, LEU495G, LEU495H, LEU496G, LEU496H, LYS367G, LYS367H, LYS368G, LYS368H, LYS392G, LYS392H, LYS453G, LYS453H, LYS484G, LYS484H, MET374G, MET374H, PHE363G, PHE363H, PRO373G, PRO373H, SER375G, SER375H, SER382G, SER382H, SER383G, SER383H, SER387G, SER387H, THR391G, THR391H, THR492G, THR492H, TYR360G, TYR360H, TYR389G, TYR389H, TYR412G, TYR412H, TYR475G, TYR475H, TYR488G, TYR488H, VAL380G, VAL380H, VAL385G, VAL385H, VAL388G, VAL388H, VAL461G, VAL477G, VAL477H, VAL478G, VAL478H, VAL485G, VAL485H, VAL497G, VAL497H
• I-J: ALA376I, ALA376J, ALA379I, ALA379J, ALA384I, ALA384J, ALA393I, ALA393J, ALA481I, ALA481J, ALA489I, ALA489J, ARG493I, ARG493J, ASN364I, ASN364J, ASN386I, ASN386J, ASN415J, ASN490I, ASN490J, ASP377I, ASP377J, ASP482I, ASP482J, CYS381I, CYS381J, CYS476I, CYS476J, GLN370I, GLN370J, GLN491I, GLN491J, GLU378I, GLU378J, GLU390I, GLU390J, GLU454I, GLU454J, GLU498I, GLU498J, GLY452I, HIS371I, HIS371J, HIS480I, HIS480J, HIS483I, HIS483J, ILE372I, ILE372J, ILE494I, ILE494J, LEU495I, LEU495J, LEU496I, LEU496J, LYS367I, LYS367J, LYS368I, LYS368J, LYS392I, LYS392J, LYS394J, LYS453I, LYS484I, LYS484J, MET374I, MET374J, PHE363I, PHE363J, PRO373I, PRO373J, SER375I, SER375J, SER382I, SER382J, SER383I, SER383J, SER387I, SER387J, THR391I, THR391J, THR492I, THR492J, TYR360I, TYR360J, TYR389I, TYR389J, TYR412I, TYR412J, TYR475I, TYR475J, TYR488I, TYR488J, VAL380I, VAL380J, VAL385I, VAL385J, VAL388I, VAL388J, VAL477I, VAL477J, VAL478I, VAL478J, VAL485I, VAL485J, VAL497I, VAL497J
• I-K: ALA261I, ALA261K, ALA271I, ALA271K, ALA277I, ALA277K, ALA288I, ALA288K, ALA295I, ALA295K, ALA311I, ALA311K, ALA317I, ALA317K, ALA319I, ALA319K, ALA347I, ALA347K, ALA353I, ALA353K, ALA356I, ALA356K, ALA4I, ALA4K, ARG103I, ARG103K, ARG262I, ARG262K, ARG307I, ARG307K, ARG310I, ARG310K, ARG348I, ARG348K, ARG413I, ARG413K, ASN167I, ASN167K, ASN178I, ASN178K, ASN241I, ASN241K, ASN247K, ASN286I, ASN286K, ASN305I, ASN305K, ASN318I, ASN318K, ASN322I, ASN322K, ASN358I, ASN358K, ASN364I, ASN364K, ASN6I, ASN6K, ASP13I, ASP13K, ASP144I, ASP144K, ASP145I, ASP145K, ASP249I, ASP249K, ASP264I, ASP264K, ASP315I, ASP315K, CYS285I, CYS285K, CYS294I, CYS294K, CYS350I, CYS350K, GLN243I, GLN243K, GLN246I, GLN246K, GLN278I, GLN278K, GLN297I, GLN297K, GLN2I, GLN2K, GLN354I, GLN370I, GLN370K, GLU102K, GLU268I, GLU268K, GLU272I, GLU272K, GLU300I, GLU300K, GLU312I, GLU312K, GLU341I, GLU341K, GLU352I, GLU352K, GLY146I, GLY146K, GLY263I, GLY263K, GLY266I, GLY266K, GLY323I, GLY323K, HIS169I, HIS169K, HIS242I, HIS242K, HIS5I, HIS5K, ILE11I, ILE11K, ILE141K, ILE143I, ILE143K, ILE147I, ILE147K, ILE149I, ILE149K, ILE248K, ILE252I, ILE252K, ILE269I, ILE269K, ILE280I, ILE280K, ILE282I, ILE282K, ILE349I, ILE349K, ILE366I, ILE366K, LEU148I, LEU148K, LEU150I, LEU150K, LEU265I, LEU265K, LEU281I, LEU281K, LEU299I, LEU299K, LEU351I, LEU351K, LEU357I, LEU357K, LEU369I, LEU369K, LEU3I, LEU3K, LEU7I, LEU7K, LEU9I, LEU9K, LYS273I, LYS273K, LYS279I, LYS279K, LYS284I, LYS284K, LYS337I, LYS337K, LYS367I, LYS367K, LYS368I, LYS368K, LYS411I, LYS411K, MET298I, MET298K, MET346I, MET346K, PHE12I, PHE12K, PHE321I, PHE321K, PHE362I, PHE362K, PHE363I, PHE363K, PRO14I, PRO14K, PRO270I, PRO270K, PRO306I, PRO306K, PRO308I, PRO308K, PRO339I, SER10I, SER10K, SER168I, SER168K, SER1I, SER1K, SER283I, SER283K, SER301I, SER301K, SER314I, SER314K, SER355I, SER355K, SER365I, SER365K, THR166I, THR166K, THR170I, THR170K, THR296I, THR296K, THR309I, THR309K, THR8I, THR8K, TYR140I, TYR140K, TYR142I, TYR142K, TYR304I, TYR304K, TYR338I, TYR338K, TYR345I, TYR345K, VAL15I, VAL15K, VAL245I, VAL245K, VAL260I, VAL260K, VAL267I, VAL267K, VAL274I, VAL274K, VAL275I, VAL275K, VAL276I, VAL276K, VAL287I, VAL287K, VAL313I, VAL313K, VAL316I, VAL316K, VAL320I, VAL320K, VAL361I, VAL361K
• I-N: ASP249I, HIS155N
• J-L: ALA261J, ALA261L, ALA271J, ALA271L, ALA277J, ALA277L, ALA288J, ALA288L, ALA295J, ALA295L, ALA311J, ALA311L, ALA317J, ALA317L, ALA319J, ALA319L, ALA347J, ALA347L, ALA353J, ALA353L, ALA356J, ALA356L, ALA4J, ALA4L, ARG103J, ARG103L, ARG262J, ARG262L, ARG307J, ARG307L, ARG310J, ARG310L, ARG348J, ARG348L, ARG413J, ARG413L, ASN167J, ASN167L, ASN178J, ASN178L, ASN241J, ASN241L, ASN247L, ASN286J, ASN286L, ASN305J, ASN305L, ASN318J, ASN318L, ASN322J, ASN322L, ASN358J, ASN358L, ASN364J, ASN364L, ASN6J, ASN6L, ASP13J, ASP13L, ASP144J, ASP144L, ASP145J, ASP145L, ASP249J, ASP249L, ASP264J, ASP264L, ASP315J, ASP315L, CYS285J, CYS285L, CYS294J, CYS294L, CYS350J, CYS350L, GLN243J, GLN243L, GLN246J, GLN246L, GLN278J, GLN278L, GLN297J, GLN297L, GLN2J, GLN2L, GLN354J, GLN354L, GLN370J, GLN370L, GLU102L, GLU268J, GLU268L, GLU272J, GLU272L, GLU300J, GLU300L, GLU312J, GLU312L, GLU332J, GLU341J, GLU341L, GLU352J, GLU352L, GLY146J, GLY146L, GLY263J, GLY263L, GLY266J, GLY266L, GLY323J, GLY323L, HIS169J, HIS169L, HIS242J, HIS242L, HIS5J, HIS5L, ILE11J, ILE11L, ILE141J, ILE141L, ILE143J, ILE143L, ILE147J, ILE147L, ILE149J, ILE149L, ILE252J, ILE252L, ILE269J, ILE269L, ILE280J, ILE280L, ILE282J, ILE282L, ILE349J, ILE349L, ILE366J, ILE366L, LEU148J, LEU148L, LEU150J, LEU150L, LEU265J, LEU265L, LEU281J, LEU281L, LEU299J, LEU299L, LEU351J, LEU351L, LEU357J, LEU357L, LEU369J, LEU369L, LEU3J, LEU3L, LEU7J, LEU7L, LEU9J, LEU9L, LYS273J, LYS273L, LYS279J, LYS279L, LYS284J, LYS284L, LYS337J, LYS337L, LYS367J, LYS367L, LYS368J, LYS368L, LYS411J, LYS411L, MET298J, MET298L, MET346J, MET346L, PHE12J, PHE12L, PHE321J, PHE321L, PHE362J, PHE362L, PHE363J, PHE363L, PRO14J, PRO14L, PRO270J, PRO270L, PRO306J, PRO306L, PRO308J, PRO308L, PRO339J, SER10J, SER10L, SER168J, SER168L, SER1J, SER1L, SER283J, SER283L, SER301J, SER301L, SER314J, SER314L, SER355J, SER355L, SER365J, SER365L, THR166J, THR166L, THR170J, THR170L, THR296J, THR296L, THR309J, THR309L, THR8J, THR8L, TYR140J, TYR140L, TYR142J, TYR142L, TYR304J, TYR304L, TYR338J, TYR338L, TYR345J, TYR345L, VAL15J, VAL15L, VAL245J, VAL245L, VAL260J, VAL260L, VAL267J, VAL267L, VAL274J, VAL274L, VAL275J, VAL275L, VAL276J, VAL276L, VAL287J, VAL287L, VAL313J, VAL313L, VAL316J, VAL316L, VAL320J, VAL320L, VAL361J, VAL361L
• K-L: ALA376K, ALA376L, ALA379K, ALA379L, ALA384K, ALA384L, ALA393K, ALA393L, ALA481K, ALA481L, ALA489K, ALA489L, ARG493K, ARG493L, ASN364K, ASN364L, ASN386K, ASN386L, ASN490K, ASN490L, ASP377K, ASP377L, ASP482K, ASP482L, CYS381K, CYS381L, CYS476K, CYS476L, GLN370K, GLN370L, GLN491K, GLN491L, GLU378K, GLU378L, GLU390K, GLU390L, GLU454K, GLU454L, GLU498K, GLU498L, GLY452L, HIS371K, HIS371L, HIS480K, HIS480L, HIS483K, HIS483L, ILE372K, ILE372L, ILE479L, ILE494K, ILE494L, LEU495K, LEU495L, LEU496K, LEU496L, LYS367K, LYS367L, LYS368K, LYS368L, LYS392K, LYS392L, LYS394K, LYS394L, LYS484K, LYS484L, MET374K, MET374L, PHE363K, PHE363L, PRO373K, PRO373L, SER375K, SER375L, SER382K, SER382L, SER383K, SER383L, SER387K, SER387L, THR391K, THR391L, THR492K, THR492L, TYR360K, TYR360L, TYR389K, TYR389L, TYR412K, TYR412L, TYR475K, TYR475L, TYR488K, TYR488L, VAL380K, VAL380L, VAL385K, VAL385L, VAL388K, VAL388L, VAL457K, VAL477K, VAL477L, VAL478K, VAL478L, VAL485K, VAL485L, VAL497K
• K-P: ASP474K, GLU35P
• M-N: ARG493M, ARG493N, ASN386N, ASN490M, ASN490N, ASP482M, ASP482N, GLU378M, GLU378N, GLU390M, GLU390N, GLU454M, GLU454N, HIS483M, HIS483N, ILE494M, ILE494N, LYS367M, LYS367N, LYS368M, LYS484M, LYS484N, MET374M, MET374N, SER383M, SER383N, THR492M, THR492N, TYR360N
• M-O: ARG103M, ARG262M, ARG262O, ARG307M, ARG307O, ARG310M, ARG310O, ARG348M, ARG348O, ASP13M, ASP13O, ASP145M, ASP145O, ASP315M, ASP315O, GLU272M, GLU272O, GLU300M, GLU300O, GLU312M, GLU312O, GLU352M, GLU352O, HIS5M, HIS5O, ILE147M, ILE147O, LYS273M, LYS273O, LYS279M, LYS279O, LYS337O
• N-P: ARG103N, ARG103P, ARG262N, ARG262P, ARG307N, ARG307P, ARG310N, ARG310P, ARG348N, ARG348P, ASN6N, ASP13N, ASP145N, ASP145P, ASP315N, ASP315P, GLN297N, GLU272N, GLU272P, GLU300N, GLU300P, GLU312N, GLU312P, GLU352N, GLU352P, GLY146N, GLY146P, HIS5N, HIS5P, ILE11N, ILE11P, ILE147N, LYS273N, LYS273P, LYS279N, LYS279P, LYS337N, LYS337P, SER283P
• O-P: ARG493O, ARG493P, ASN490O, ASN490P, ASP482O, ASP482P, GLN491O, GLN491P, GLU378O, GLU378P, GLU390O, GLU390P, GLU454O, GLU454P, HIS480O, HIS483O, HIS483P, ILE494O, ILE494P, LYS367O, LYS367P, LYS484O, LYS484P, MET374O, MET374P, SER382O, SER383O, SER383P, THR391P, THR492O, THR492P