3HOU

complete rna polymerase ii elongation complex i with a t-u mismatch

• Total interactions analyzed: 435
• Total true interactions: 60
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 776
  • Norm. En. per Res.: -4.4967
• Hub Node: B(11)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-493.1815	-342.0537	-2654.22	-3489.4552	776	204	67	110816	30	267	232
A-C	-23.0342	5.9991	-74.3827	-91.4178	50	11	0	3141	0	16	17
A-D	-4.1423	-19.8227	-43.44	-67.405	39	2	1	2401	1	12	5
A-E	-91.1377	-87.529	-573.539	-752.2058	198	48	14	23818	6	79	64
A-F	-100.5461	-40.6791	-509.825	-651.0501	176	32	15	21476	2	64	53
A-G	-21.2511	-67.4647	-122.537	-211.2528	62	13	5	5643	3	19	15
A-H	-97.76	-18.0595	-382.875	-498.6945	135	66	12	17456	3	35	33
A-I	-80.609	-22.1781	-441.05	-543.8371	141	42	10	17588	6	51	48
A-K	-37.2128	-34.442	-261.419	-333.0738	94	14	8	9971	3	23	18
A-P	-3.0918	-14.9036			17
B-C	-87.7507	-118.3569	-470.368	-676.4755	169	49	5	18173	6	56	60
B-D	0.0	-13.9769	-63.2426	-77.2195	41	2	1	2778	1	16	18
B-E	0.0	0.0	-1.2448	-1.2448	8	4	0	493	0	2	1
B-F	0.0	5.4185	-12.139	-6.7204	24	0	0	593	0	6	7
B-G	-4.1684	-3.4001	-8.5421	-16.1106	26	0	0	755	0	7	4
B-H	0.0	0.0	-0.2529	-0.2529	2	0	0	39	0	0	0
B-I	-24.6053	-86.6411	-274.131	-385.3774	132	29	2	13784	5	52	52
B-J	-23.1218	-33.6743	-397.538	-454.3341	139	39	7	18536	5	35	36
B-K	-8.4326	-26.1023	-85.8983	-120.4332	56	7	0	3382	3	15	19
B-L	-61.8009	-76.0563	-229.684	-367.5412	112	25	8	11025	12	48	45
B-S	0.0	-4.358			4
C-H	0.0	-2.6573	-32.5381	-35.1954	24	1	1	1462	0	8	6
C-J	-51.4711	-41.8146	-222.282	-315.5677	105	32	11	12323	9	38	26
C-K	-41.4107	-28.5957	-513.676	-583.6824	153	56	18	23386	6	48	47
C-L	-36.0457	-36.5948	-169.286	-241.9265	62	14	9	6163	6	24	16
D-G	-64.4424	-39.5016	-629.51	-733.454	201	49	23	25664	10	55	50
D-M	-5.8917	-9.4452	-43.8565	-59.1934	42	6	0	1939	5	39	22
E-F	-6.7972	-19.8507	-23.0426	-49.6905	22	4	0	1216	0	6	4
F-G	-3.0415	-11.686	-106.526	-121.2535	54	15	1	4875	1	10	11
G-M	0.0	0.0	-0.7928	-0.7928	3	0	0	79	0	3	0
G-N	0.0	-3.2325	0.0	-3.2325	2	0	0	0	0	0	0
G-S	0.0	17.8933			11
H-K	0.0	0.0	-34.1004	-34.1004	25	2	0	1702	0	5	5
J-L	0.0	0.0	-9.541	-9.541	10	2	0	483	0	0	1
K-L	0.0	8.4237	-0.8648	7.5589	5	0	0	147	0	3	2
M-N	-553.4481	-348.8323	-1036.91	-1939.1904	482	89	16	44188	3	113	101
M-O	-11.7682	6.9645			7
M-P	-5.447	-18.8616			5
M-Q	-87.1878	-93.9449			35
M-R	-84.1227	-39.0015			23
M-S	-18.3048	-58.7112			11
M-T	-94.5654	-23.1808			27
M-U	-77.6722	-20.6883			29
M-W	-35.0766	-31.9584			16
N-O	-67.5173	-113.3274			38
N-P	0.0	-15.0757			6
N-R	0.0	-1.9233			3
N-S	-3.0526	-2.9967			4
N-U	-31.5775	-87.0591			22
N-V	-35.12	-35.9646			17
N-W	-12.1677	-22.2539			10
N-X	-57.9581	-64.1959			32
O-T	0.0	-6.3677			4
O-V	-48.3387	-44.0568			23
O-W	-43.915	-20.6882			27
O-X	-39.2015	-37.2337			16
P-S	-64.9798	-27.3548			34
Q-R	-5.7482	-20.5613			4
R-S	-5.0449	-10.7649			6
W-X	0.0	8.1684			2

Interface residues

• A-B: ALA1016B, ALA1024B, ALA1068A, ALA1069A, ALA1083B, ALA1105B, ALA1107B, ALA1140B, ALA1143B, ALA1144B, ALA1149A, ALA1154B, ALA1157B, ALA1173B, ALA1199B, ALA1200B, ALA1209B, ALA1396A, ALA1412A, ALA1414A, ALA1416A, ALA1434A, ALA1440A, ALA266B, ALA29A, ALA327A, ALA349A, ALA371A, ALA457A, ALA472B, ALA480A, ALA499A, ALA506A, ALA509B, ALA525B, ALA532B, ALA671A, ALA684A, ALA695B, ALA704B, ALA726B, ALA735B, ALA749A, ALA753B, ALA759A, ALA763A, ALA776A, ALA817A, ALA826B, ALA828A, ALA828B, ALA832A, ALA937B, ALA9A, ARG1020B, ARG1067B, ARG1106B, ARG1108B, ARG1116B, ARG1122B, ARG1124B, ARG1129B, ARG1135B, ARG1150B, ARG1159B, ARG1215B, ARG1220B, ARG1222B, ARG12A, ARG1422A, ARG247A, ARG261B, ARG267B, ARG28A, ARG320A, ARG326A, ARG328A, ARG335A, ARG337A, ARG344A, ARG350A, ARG412A, ARG416A, ARG446A, ARG469A, ARG47A, ARG498A, ARG512B, ARG57A, ARG617B, ARG620B, ARG635B, ARG63A, ARG677A, ARG728B, ARG730B, ARG766B, ARG782A, ARG806A, ARG821A, ARG839A, ARG857A, ARG884B, ARG935B, ASN1013B, ASN1074B, ASN1176B, ASN1178B, ASN1211B, ASN1265A, ASN1393A, ASN1427A, ASN225A, ASN253A, ASN339A, ASN358A, ASN445A, ASN471A, ASN479A, ASN488A, ASN516B, ASN538B, ASN548A, ASN654A, ASN660A, ASN741A, ASN742A, ASN757A, ASN75A, ASN762B, ASN767B, ASN802A, ASN834B, ASN858A, ASN862A, ASP1100B, ASP1101B, ASP1125B, ASP1136B, ASP1156B, ASP1186B, ASP1190B, ASP1219B, ASP1223B, ASP1419A, ASP1420A, ASP260A, ASP305A, ASP346A, ASP356A, ASP394B, ASP397B, ASP399B, ASP481A, ASP483A, ASP485A, ASP526A, ASP544A, ASP618B, ASP668A, ASP672A, ASP694B, ASP724B, ASP760B, ASP781A, ASP790A, ASP791A, ASP826A, ASP837B, ASP847A, ASP936B, ASP978B, ASP998B, CYS1029B, CYS1137B, CYS1166B, CYS1182B, CYS1185B, CYS1400A, CYS1421A, CYS238A, CYS505A, CYS523B, CYS529A, CYS533B, CYS67A, CYS70A, CYS764A, CYS77A, CYS829B, GLN1065B, GLN1070A, GLN1084B, GLN1112B, GLN1117B, GLN1179B, GLN1193B, GLN1205B, GLN1432A, GLN18A, GLN256A, GLN313A, GLN316A, GLN447A, GLN469B, GLN493A, GLN4A, GLN510A, GLN513B, GLN525A, GLN531B, GLN545A, GLN5A, GLN650A, GLN68A, GLN706B, GLN71A, GLN745A, GLN760A, GLN763B, GLN768A, GLN811A, GLN835B, GLN838A, GLN843B, GLN975B, GLN986B, GLU1028B, GLU1053B, GLU1062A, GLU1070B, GLU1120B, GLU1132B, GLU1134B, GLU1149B, GLU1151A, GLU1153B, GLU1206B, GLU1264A, GLU1269A, GLU1407A, GLU1411A, GLU1417A, GLU1426A, GLU16A, GLU254A, GLU25A, GLU262B, GLU26A, GLU312B, GLU319B, GLU333A, GLU433A, GLU486A, GLU495A, GLU496A, GLU500A, GLU526B, GLU529B, GLU542A, GLU621B, GLU681A, GLU696B, GLU697B, GLU698B, GLU699B, GLU72A, GLU742B, GLU76A, GLU771A, GLU795A, GLU801A, GLU812A, GLU822A, GLU833A, GLU836B, GLU846A, GLY1061A, GLY1065A, GLY1068B, GLY1075B, GLY1078B, GLY1109B, GLY1121B, GLY1126B, GLY1127B, GLY1131B, GLY1142B, GLY1164B, GLY1167B, GLY1184B, GLY1395A, GLY1413A, GLY1431A, GLY1437A, GLY1439A, GLY20A, GLY263B, GLY319A, GLY334A, GLY338A, GLY342A, GLY355A, GLY3A, GLY402B, GLY484A, GLY520B, GLY530A, GLY530B, GLY534B, GLY59A, GLY661A, GLY665A, GLY667A, GLY673A, GLY73A, GLY750A, GLY750B, GLY753A, GLY772A, GLY778A, GLY79A, GLY807A, GLY819A, GLY820A, GLY823A, GLY832B, GLY835A, GLY861A, GLY94A, GLY977B, GLY988B, GLY991B, HIS1015B, HIS1025B, HIS1076B, HIS1097B, HIS1104B, HIS1141B, HIS1161B, HIS1177B, HIS1195B, HIS1258A, HIS400B, HIS451A, HIS490A, HIS515B, HIS518B, HIS659A, HIS733B, HIS734B, HIS740B, HIS744B, HIS761B, HIS786A, HIS80A, HIS816A, HIS92A, ILE1011B, ILE1012B, ILE1017B, ILE1027B, ILE1050B, ILE1055B, ILE1085B, ILE1103B, ILE1139B, ILE1162B, ILE1165B, ILE1172B, ILE1189B, ILE1191B, ILE1194B, ILE1196B, ILE1212B, ILE1408A, ILE1429A, ILE1436A, ILE235A, ILE250A, ILE30A, ILE325A, ILE336A, ILE353A, ILE370A, ILE406A, ILE436A, ILE463A, ILE523A, ILE541A, ILE619B, ILE666A, ILE670A, ILE679A, ILE683A, ILE693B, ILE701B, ILE703B, ILE729B, ILE748B, ILE756A, ILE756B, ILE758A, ILE775A, ILE825A, ILE827B, ILE840B, ILE848A, ILE870B, ILE918B, ILE976B, ILE990B, ILE992B, LEU1026B, LEU1030B, LEU1031B, LEU1059B, LEU1067A, LEU1081B, LEU1095B, LEU1114B, LEU1128B, LEU1147B, LEU1151B, LEU1168B, LEU1175B, LEU11A, LEU1202B, LEU1203B, LEU1207B, LEU1216B, LEU1268A, LEU1397A, LEU1409A, LEU1418A, LEU1430A, LEU21A, LEU236A, LEU239A, LEU262A, LEU266A, LEU315A, LEU329A, LEU340A, LEU359A, LEU374A, LEU443A, LEU450A, LEU470A, LEU472A, LEU489A, LEU501A, LEU504A, LEU508B, LEU509A, LEU514B, LEU521B, LEU528A, LEU535B, LEU58A, LEU637B, LEU657A, LEU658A, LEU65A, LEU702B, LEU710B, LEU740A, LEU749B, LEU784A, LEU805A, LEU808A, LEU824A, LEU845A, LEU860A, LYS1079B, LYS1080B, LYS1102A, LYS1102B, LYS1112A, LYS1144A, LYS1148B, LYS1174B, LYS1183B, LYS1201B, LYS1261A, LYS1262A, LYS15A, LYS315B, LYS330A, LYS332A, LYS343A, LYS368A, LYS372A, LYS393B, LYS403A, LYS431A, LYS452A, LYS470B, LYS510B, LYS533A, LYS537B, LYS687A, LYS727B, LYS744A, LYS752A, LYS789A, LYS830A, LYS843A, LYS864B, LYS934B, LYS979B, LYS987B, MET1021B, MET1063A, MET1072B, MET1082B, MET1098B, MET1111B, MET1133B, MET1138B, MET1152B, MET1169B, MET1208B, MET1210B, MET1398A, MET1433A, MET234A, MET304A, MET341A, MET453A, MET455A, MET456A, MET473B, MET487A, MET676A, MET705B, MET746A, MET747B, MET74A, MET761A, MET818A, MET839B, MET849A, MET885B, MET999B, PHE1047B, PHE1069B, PHE1086B, PHE1087B, PHE1130B, PHE1146B, PHE1158B, PHE1180B, PHE1204B, PHE1224B, PHE1402A, PHE1410A, PHE1441A, PHE19A, PHE228A, PHE22A, PHE252A, PHE347A, PHE401B, PHE444A, PHE468A, PHE482A, PHE540A, PHE655A, PHE662A, PHE738B, PHE758B, PHE777A, PHE779A, PHE787A, PHE813A, PHE814A, PHE815A, PHE81A, PHE95A, PHE980B, PRO1000B, PRO1014B, PRO1018B, PRO1046B, PRO1099A, PRO10A, PRO1110B, PRO1118B, PRO1197B, PRO1214B, PRO1435A, PRO240A, PRO242A, PRO243A, PRO244A, PRO245A, PRO248A, PRO24A, PRO321A, PRO357A, PRO367A, PRO377A, PRO441A, PRO448A, PRO464A, PRO492A, PRO511B, PRO514A, PRO524B, PRO528B, PRO725B, PRO745B, PRO759B, PRO765B, PRO785A, PRO78A, PRO794A, PRO810A, PRO917B, SER1019B, SER1056B, SER1066B, SER1071A, SER1145B, SER1150A, SER1155B, SER1221B, SER1401A, SER1415A, SER1425A, SER229A, SER23A, SER249A, SER251A, SER255A, SER264B, SER265B, SER318A, SER31A, SER324A, SER348A, SER354A, SER369A, SER449A, SER454A, SER466A, SER473A, SER474B, SER476A, SER494A, SER540B, SER663A, SER700B, SER732B, SER746B, SER751A, SER754A, SER762A, SER764B, SER769A, SER788A, SER793A, SER796A, SER7A, SER803A, SER831B, SER838B, SER859A, SER8A, SER919B, SER933B, THR1022B, THR1048B, THR1051B, THR1077A, THR1077B, THR1115B, THR1170B, THR1213B, THR1218B, THR1266A, THR1394A, THR13A, THR1405A, THR1438A, THR237A, THR351A, THR373A, THR375A, THR467A, THR475A, THR497A, THR517B, THR527A, THR527B, THR539A, THR664A, THR669A, THR680A, THR69A, THR736B, THR737B, THR739B, THR768B, THR783A, THR809A, THR827A, THR831A, THR834A, THR916B, THR989B, THR993B, TRP233A, TRP308B, TRP519B, TRP552A, TRP656A, TYR1073B, TYR1192B, TYR1198B, TYR1217B, TYR303A, TYR376A, TYR404A, TYR465A, TYR478A, TYR6A, TYR769B, TYR804A, TYR830B, TYR833B, TYR836A, TYR866B, TYR994B, VAL1023B, VAL1052B, VAL1064A, VAL1066A, VAL1099B, VAL1113B, VAL1119B, VAL1160B, VAL1171B, VAL1406A, VAL1424A, VAL1428A, VAL14A, VAL17A, VAL227A, VAL241A, VAL246A, VAL27A, VAL2A, VAL300A, VAL32A, VAL345A, VAL352A, VAL366A, VAL442A, VAL491A, VAL507A, VAL522B, VAL524A, VAL536B, VAL723B, VAL731B, VAL743A, VAL747A, VAL765A, VAL770A, VAL780A, VAL800A, VAL829A, VAL842A, VAL93A
• A-C: ALA223C, ALA671A, ASN660A, ASN736A, ASN741A, ASN742A, ASP190C, ASP196C, ASP220C, ASP538A, ASP544A, ASP668A, ASP672A, ASP739A, GLN195C, GLN224C, GLN745A, GLU194C, GLU200C, GLU542A, GLY665A, GLY667A, GLY673A, HIS188C, HIS659A, ILE666A, ILE670A, LEU186C, LEU571A, LEU737A, LEU740A, LYS222C, LYS533A, LYS567A, LYS569A, LYS738A, PHE219C, PRO568A, PRO570A, PRO674A, SER197C, THR189C, THR664A, THR669A, THR675A, TRP192C, TYR191C, TYR193C, TYR221C, VAL743A
• A-D: ALA29A, ALA9A, ARG12A, ARG12D, ARG13D, ARG14D, ARG230A, ASN225A, GLN18A, GLU16A, GLU226A, GLU26A, GLY20A, LEU11A, LEU1418A, LEU15D, LEU21A, LYS15A, LYS16D, LYS17D, LYS76D, MET1454A, PHE228A, PHE22A, PRO10A, PRO1455A, SER229A, SER23A, SER4D, SER6D, SER7A, SER8A, THR10D, THR5D, TRP233A, TYR6A, VAL17A, VAL227A, VAL3D
• A-E: ALA1010A, ALA1014A, ALA1343A, ALA1346A, ALA1347A, ALA1369A, ALA138E, ALA139E, ALA181E, ALA185E, ALA209E, ARG1012A, ARG11E, ARG1215A, ARG1289A, ARG1326A, ARG1345A, ARG1366A, ARG1422A, ARG14E, ARG162E, ARG167E, ARG169E, ARG177E, ARG180E, ARG192E, ARG200E, ARG207E, ARG212E, ARG7E, ARG857A, ARG944A, ASN1004A, ASN1009A, ASN1364A, ASN1393A, ASN143E, ASN854A, ASN858A, ASN862A, ASP1013A, ASP1323A, ASP1334A, ASP1373A, ASP159E, ASP182E, ASP853A, ASP871A, CYS1019A, CYS1020A, GLN1008A, GLN1011A, GLN1218A, GLN124A, GLN1378A, GLN174E, GLN179E, GLN865A, GLU1005A, GLU1121A, GLU120A, GLU1315A, GLU1337A, GLU1342A, GLU137E, GLU148E, GLU160E, GLU163E, GLU172E, GLU203E, GLU870A, GLU945A, GLY1002A, GLY1321A, GLY1340A, GLY1344A, GLY1379A, GLY1380A, GLY206E, GLY861A, GLY869A, GLY872A, HIS146E, HIS147E, HIS153E, ILE1006A, ILE1007A, ILE128A, ILE1322A, ILE1327A, ILE1335A, ILE1341A, ILE144E, ILE178E, ILE198E, ILE199E, ILE213E, ILE864A, ILE867A, ILE878A, LEU1000A, LEU1017A, LEU121A, LEU1313A, LEU1339A, LEU1348A, LEU1381A, LEU140E, LEU149E, LEU156E, LEU164E, LEU165E, LEU170E, LEU175E, LEU186E, LEU860A, LEU883A, LEU943A, LEU956A, LYS1003A, LYS122E, LYS129A, LYS133A, LYS1350A, LYS152E, LYS161E, LYS166E, LYS171E, LYS197E, LYS201E, LYS938A, LYS941A, MET1317A, MET1336A, MET1368A, MET1375A, MET215E, MET873A, PHE1018A, PHE1332A, PHE866A, PHE942A, PHE947A, PRO125E, PRO1320A, PRO1324A, PRO151E, PRO176E, PRO183E, PRO955A, PRO957A, SER10E, SER1314A, SER1392A, SER173E, SER202E, SER205E, SER210E, SER859A, THR1016A, THR1117A, THR1318A, THR1325A, THR1329A, THR1376A, THR1377A, THR1382A, THR145E, THR204E, THR855A, THR856A, TRP954A, TYR1119A, TYR1328A, TYR1349A, TYR1353A, TYR1362A, TYR1365A, TYR168E, TYR208E, TYR211E, TYR868A, VAL1015A, VAL1316A, VAL1319A, VAL1338A, VAL1363A, VAL1372A, VAL141E, VAL142E, VAL150E, VAL184E, VAL195E, VAL196E, VAL863A, VAL946A, VAL948A, VAL999A
• A-F: ALA1051A, ALA105F, ALA121F, ALA1434A, ALA1440A, ALA499A, ALA80F, ALA876A, ALA91F, ALA98F, ARG1001A, ARG1055A, ARG119F, ARG135F, ARG136F, ARG1422A, ARG387A, ARG434A, ARG498A, ARG79F, ARG857A, ARG90F, ARG92F, ARG97F, ASN1004A, ASN104F, ASN384A, ASN854A, ASN858A, ASN862A, ASP110F, ASP116F, ASP140F, ASP1442A, ASP1446A, ASP145F, ASP154F, ASP77F, ASP853A, ASP874A, CYS505A, GLN100F, GLN1052A, GLN427A, GLN493A, GLN503A, GLN510A, GLN640A, GLN78F, GLU1050A, GLU1062A, GLU114F, GLU124F, GLU127F, GLU1447A, GLU1448A, GLU144F, GLU149F, GLU150F, GLU378A, GLU495A, GLU496A, GLU500A, GLU89F, GLY1002A, GLY1061A, GLY113F, GLY141F, GLY1437A, GLY1439A, GLY429A, GLY861A, GLY95F, HIS1059A, HIS851A, HIS877A, ILE1007A, ILE101F, ILE120F, ILE130F, ILE134F, ILE1436A, ILE1445A, ILE152F, ILE385A, ILE93F, LEU1000A, LEU1054A, LEU1067A, LEU111F, LEU118F, LEU125F, LEU132F, LEU138F, LEU1450A, LEU155F, LEU501A, LEU504A, LEU509A, LEU860A, LEU94F, LEU998A, LEU99F, LYS1003A, LYS128F, LYS129F, LYS1452A, LYS15A, LYS431A, LYS452A, LYS76F, LYS87F, MET103F, MET1063A, MET122F, MET1433A, MET1444A, MET1454A, MET849A, MET85F, PHE108F, PHE143F, PHE1441A, PRO1060A, PRO106F, PRO117F, PRO131F, PRO139F, PRO1435A, PRO1455A, PRO377A, PRO382A, PRO441A, PRO514A, PRO639A, PRO83F, SER102F, SER142F, SER1449A, SER147F, SER494A, SER502A, THR115F, THR1438A, THR381A, THR497A, THR81F, THR82F, THR855A, THR86F, THR96F, TRP146F, TRP430A, TYR137F, TYR1453A, TYR376A, TYR383A, TYR428A, TYR84F, TYR852A, TYR88F, VAL1057A, VAL1058A, VAL1064A, VAL107F, VAL109F, VAL133F, VAL1443A, VAL1451A, VAL148F, VAL153F, VAL379A, VAL380A, VAL850A, VAL863A, VAL999A
• A-G: ALA68G, ARG12A, ARG21G, ARG58G, ARG60G, ASN10G, ASP1442A, ASP1446A, ASP65G, GLN1432A, GLN24G, GLN493A, GLN57G, GLU1447A, GLU1448A, GLU33G, GLU495A, GLU496A, GLU69G, GLY1439A, GLY19G, GLY429A, GLY59G, GLY66G, HIS14G, ILE1445A, ILE56G, ILE61G, LEU11A, LEU13G, LEU1450A, LEU26G, LEU62G, LEU9G, LYS1452A, LYS15A, LYS23G, MET1433A, MET1444A, MET1454A, MET22G, PHE1441A, PHE17G, PHE18G, PHE70G, PRO10A, PRO15G, PRO20G, PRO63G, SER1449A, SER494A, SER67G, THR12G, THR13A, THR1438A, THR497A, THR64G, TYR1453A, TYR6A, VAL1443A, VAL1451A, VAL379A
• A-H: ALA101H, ALA113H, ALA140H, ALA564A, ARG1036A, ARG124H, ARG19H, ARG25H, ARG532A, ARG537A, ARG77H, ARG80H, ASN131H, ASN21H, ASN43H, ASN603A, ASN736A, ASN741A, ASP16H, ASP41H, ASP538A, ASP557A, ASP602A, ASP609A, ASP739A, ASP91H, ASP94H, ASP974A, CYS24H, GLN576A, GLN589A, GLN611A, GLU105H, GLU106H, GLU138H, GLU27H, GLU45H, GLU542A, GLY119H, GLY120H, GLY18H, GLY558A, GLY574A, GLY615A, GLY99H, HIS975A, ILE144H, ILE26H, ILE42H, ILE560A, ILE565A, ILE566A, ILE577A, ILE608A, ILE612A, ILE613A, LEU121H, LEU122H, LEU125H, LEU142H, LEU143H, LEU38H, LEU40H, LEU46H, LEU536A, LEU543A, LEU547A, LEU550A, LEU571A, LEU597A, LEU598A, LEU606A, LEU63H, LEU737A, LEU740A, LYS103H, LYS136H, LYS22H, LYS567A, LYS569A, LYS575A, LYS601A, LYS738A, LYS744A, LYS977A, MET123H, MET605A, MET748A, MET97H, PHE104H, PHE118H, PHE47H, PHE540A, PHE591A, PHE614A, PRO48H, PRO561A, PRO563A, PRO568A, PRO570A, PRO600A, PRO81H, PRO82H, SER117H, SER573A, SER579A, SER599A, SER78H, THR100H, THR39H, THR535A, THR539A, THR562A, THR596A, THR76H, THR976A, TRP556A, TRP572A, TRP79H, TYR102H, TYR115H, TYR116H, TYR141H, TYR20H, TYR93H, TYR95H, TYR98H, VAL114H, VAL23H, VAL44H, VAL546A, VAL559A, VAL616A, VAL735A, VAL96H
• A-I: ALA1149A, ALA1200A, ALA1201A, ALA1254A, ALA38I, ALA697A, ALA699A, ALA704A, ARG1194A, ARG1199A, ARG1281A, ARG17I, ARG24I, ARG30I, ARG45I, ARG70I, ARG711A, ARG73I, ARG782A, ARG91I, ARG92I, ASN116I, ASN1265A, ASN22I, ASN23I, ASN51I, ASN700A, ASN717A, ASP113I, ASP1155A, ASP1157A, ASP1198A, ASP1257A, ASP19I, ASP65I, ASP781A, ASP790A, ASP791A, ASP94I, GLN114I, GLN698A, GLN87I, GLN89I, GLN90I, GLU1151A, GLU1196A, GLU1255A, GLU1256A, GLU1264A, GLU1269A, GLU18I, GLU47I, GLU696A, GLU712A, GLU715A, HIS1258A, HIS46I, ILE1148A, ILE1152A, ILE1163A, ILE49I, ILE62I, LEU1143A, LEU1192A, LEU1193A, LEU1195A, LEU1197A, LEU1260A, LEU1268A, LEU25I, LEU26I, LEU42I, LEU48I, LEU68I, LEU701A, LEU702A, LEU710A, LEU99I, LYS1144A, LYS115I, LYS1235A, LYS1261A, LYS1262A, LYS20I, LYS695A, LYS789A, LYS93I, MET13I, MET708A, MET97I, PHE100I, PHE101I, PHE27I, PHE714A, PHE777A, PHE779A, PHE787A, PHE85I, PHE86I, PRO1156A, PRO1158A, PRO1164A, PRO1190A, PRO16I, PRO41I, PRO66I, PRO69I, PRO785A, SER112I, SER1145A, SER1150A, SER1189A, SER40I, SER713A, SER788A, SER88I, SER96I, THR111I, THR1142A, THR1147A, THR1161A, THR2I, THR50I, THR67I, THR694A, THR703A, THR709A, THR95I, TRP1191A, TYR1153A, TYR1154A, TYR15I, TYR44I, TYR792A, VAL1146A, VAL1162A, VAL43I, VAL693A, VAL718A, VAL780A, VAL98I
• A-K: ALA27K, ALA30K, ALA371A, ALA3K, ALA48K, ALA59K, ALA60K, ARG469A, ARG47K, ARG54K, ARG6K, ARG70K, ARG74K, ASN2K, ASN358A, ASN44K, ASN548A, ASP24K, ASP356A, ASP544A, ASP555A, ASP557A, ASP5K, GLN545A, GLN76K, GLU14K, GLU398A, GLU542A, GLU64K, GLU8K, GLY355A, GLY365A, GLY558A, HIS40K, HIS659A, HIS65K, ILE33K, ILE370A, ILE463A, ILE560A, ILE75K, LEU359A, LEU51K, LEU543A, LEU547A, LEU550A, LEU57K, LEU658A, LEU73K, LEU9K, LYS26K, LYS368A, LYS372A, LYS461A, LYS62K, LYS644A, LYS651A, LYS72K, MET1K, MET549A, PHE58K, PHE655A, PHE67K, PHE68K, PHE71K, PRO28K, PRO357A, PRO367A, PRO464A, PRO4K, PRO554A, PRO561A, PRO66K, SER354A, SER369A, SER466A, THR25K, THR34K, THR351A, THR467A, TRP552A, TRP556A, TYR465A, TYR551A, TYR61K, VAL31K, VAL32K, VAL366A, VAL462A, VAL546A, VAL553A, VAL559A, VAL56K, VAL63K
• A-P: ARG209P, ARG28A, ARG36A, ASP186P, ASP189P, ASP204P, ASP205P, ASP85A, GLU190P, GLU206P, GLU208P, GLU277A, GLU280A, HIS281A, HIS83A, LYS192P, LYS34A
• B-C: ALA1003B, ALA1083B, ALA164C, ALA168C, ALA173C, ALA174C, ALA175C, ALA198C, ALA225C, ALA28C, ALA30C, ALA39C, ALA59C, ALA64C, ARG1060B, ARG1067B, ARG148C, ARG34C, ARG35C, ARG66C, ARG848B, ARG852B, ARG904B, ARG967B, ARG969B, ARG995B, ARG996B, ASN1074B, ASN184C, ASN206C, ASN231C, ASN31C, ASN54C, ASN784B, ASN786B, ASN842B, ASP181C, ASP190C, ASP60C, ASP847B, ASP950B, ASP998B, GLN1065B, GLN1084B, GLN151C, GLN195C, GLN203C, GLN843B, GLU1004B, GLU1053B, GLU1070B, GLU166C, GLU177C, GLU179C, GLU194C, GLU200C, GLU233C, GLU40C, GLU50C, GLU61C, GLU997B, GLY1005B, GLY1063B, GLY1068B, GLY1075B, GLY1078B, GLY171C, GLY849B, GLY902B, GLY947B, HIS1062B, HIS1076B, HIS167C, HIS188C, HIS65C, ILE1006B, ILE1085B, ILE144C, ILE163C, ILE176C, ILE38C, ILE63C, ILE795B, ILE846B, ILE948B, ILE973B, LEU1059B, LEU1081B, LEU186C, LEU27C, LEU58C, LEU69C, LEU796B, LEU850B, LEU854B, LYS1079B, LYS1080B, LYS149C, LYS165C, LYS169C, LYS185C, LYS187C, LYS191B, LYS199C, LYS972B, MET1072B, MET1082B, MET230C, MET29C, MET37C, MET999B, PHE1001B, PHE1069B, PHE1086B, PHE178C, PHE228C, PHE62C, PHE855B, PHE856B, PRO1000B, PRO172C, PRO182C, PRO202C, PRO799B, PRO901B, SER1056B, SER1066B, SER187B, SER197C, SER204C, SER32C, SER844B, SER845B, SER853B, THR1002B, THR1077B, THR189C, THR55C, THR56C, THR783B, THR970B, THR971B, TRP170C, TRP183C, TRP192C, TRP201C, TYR1064B, TYR1073B, TYR180C, TYR190B, TYR191C, TYR193C, TYR229C, TYR785B, TYR797B, TYR798B, TYR830B, TYR994B, VAL1007B, VAL1052B, VAL1071B, VAL232C, VAL235C, VAL36C, VAL49C, VAL51C, VAL57C, VAL787B, VAL949B
• B-D: ARG11D, ARG1215B, ARG1220B, ARG1222B, ARG12D, ARG13D, ARG14D, ASN1187B, ASP1186B, ASP1190B, ASP1219B, ASP1223B, CYS1163B, CYS1166B, CYS1182B, CYS1185B, GLN1193B, GLU20D, GLY1164B, GLY1167B, GLY1184B, ILE1165B, ILE1189B, ILE1191B, LEU1168B, LEU1216B, LEU15D, LYS1183B, LYS16D, LYS17D, SER1221B, SER4D, SER6D, THR10D, THR1213B, THR1218B, THR5D, TYR1192B, TYR1217B, VAL18D, VAL3D
• B-E: ARG1222B, ASP1223B, GLN174E, GLU172E, LEU170E, LYS171E, PHE1224B, SER173E
• B-F: ALA1140B, ALA1143B, ALA1144B, ALA91F, ARG1220B, ARG92F, ASP1223B, ASP140F, GLY1142B, GLY141F, GLY95F, HIS1141B, ILE1139B, LEU69F, LEU99F, LYS72F, LYS87F, MET1138B, PHE1224B, PRO139F, SER1145B, SER142F, THR96F, TYR88F
• B-G: ALA1144B, ASN1178B, ASP1190B, ASP65G, CYS38G, GLN1179B, GLN153G, GLU1149B, GLU1153B, GLY40G, HIS1177B, HIS1195B, ILE1189B, LEU62G, LYS1148B, LYS1188B, LYS41G, MET1152B, PHE42G, PRO63G, SER1145B, SER152G, THR39G, THR64G, TYR1192B, VAL154G
• B-H: LYS22H, MET1082B
• B-I: ALA56I, ALA577B, ALA594B, ALA735B, ARG267B, ARG287B, ARG30I, ARG392B, ARG45I, ARG595B, ARG5I, ARG601B, ARG617B, ARG620B, ARG70I, ARG91I, ARG92I, ASN11I, ASN12I, ASN306B, ASN51I, ASN592B, ASP294B, ASP304B, ASP307B, ASP320B, ASP391B, ASP394B, ASP576B, ASP618B, ASP61I, ASP65I, ASP94I, ASP9I, CYS10I, CYS29I, CYS302B, CYS317B, CYS32I, CYS388B, CYS7I, GLN309B, GLN325B, GLN395B, GLN60I, GLN87I, GLN89I, GLN90I, GLU262B, GLU296B, GLU299B, GLU312B, GLU319B, GLU47I, GLU54I, GLU621B, GLU623B, GLU697B, GLU698B, GLU699B, GLY263B, GLY295B, GLY53I, GLY57I, GLY63I, HIS46I, HIS734B, HIS740B, ILE292B, ILE297B, ILE52I, ILE619B, ILE62I, ILE701B, ILE703B, LEU14I, LEU298B, LEU311B, LEU314B, LEU387B, LEU390B, LEU42I, LEU48I, LEU68I, LEU702B, LYS227B, LYS315B, LYS393B, LYS622B, LYS649B, LYS93I, MET13I, MET310B, MET313B, PHE100I, PHE27I, PHE322B, PHE4I, PHE6I, PHE738B, PHE85I, PHE86I, PRO16I, PRO293B, PRO316B, PRO593B, PRO66I, PRO69I, SER264B, SER64I, SER700B, SER88I, THR2I, THR31I, THR3I, THR50I, THR55I, THR578B, THR67I, THR736B, THR737B, THR739B, THR95I, TRP308B, TYR15I, TYR44I, VAL305B, VAL318B, VAL43I, VAL58I, VAL59I, VAL84I
• B-J: ALA1003B, ALA1035B, ALA1036B, ALA35J, ALA823B, ARG43J, ARG47J, ARG48J, ARG62J, ARG6J, ARG788B, ARG815B, ARG848B, ARG852B, ARG996B, ASN1040B, ASN64J, ASN784B, ASN786B, ASN822B, ASN842B, ASP1009B, ASP188B, ASP198B, ASP31J, ASP55J, ASP847B, CYS1029B, CYS10J, CYS195B, CYS45J, CYS46J, CYS7J, GLN115B, GLN800B, GLN821B, GLN843B, GLN951B, GLU1004B, GLU1041B, GLU1070B, GLU186B, GLU194B, GLU32J, GLU58J, GLU816B, GLY1005B, GLY1039B, GLY1042B, GLY1068B, GLY1088B, GLY11J, GLY33J, GLY779B, GLY820B, GLY849B, HIS1062B, HIS53J, ILE1006B, ILE2J, ILE50J, ILE57J, ILE795B, ILE824B, ILE846B, LEU1010B, LEU1037B, LEU1059B, LEU189B, LEU192B, LEU36J, LEU41J, LEU51J, LEU56J, LEU61J, LEU782B, LEU796B, LEU803B, LEU817B, LEU850B, LEU854B, LYS1033B, LYS12J, LYS191B, LYS193B, LYS42J, LYS59J, LYS801B, MET1072B, MET1J, MET49J, PHE1087B, PHE197B, PHE60J, PHE781B, PHE814B, PHE851B, PHE8J, PRO1008B, PRO1089B, PRO196B, PRO4J, PRO65J, PRO799B, PRO802B, PRO818B, SER1032B, SER1038B, SER187B, SER37J, SER844B, SER845B, SER853B, SER9J, THR1002B, THR1090B, THR185B, THR34J, THR52J, THR783B, TRP18J, TYR1064B, TYR1091B, TYR190B, TYR21J, TYR44J, TYR63J, TYR785B, TYR797B, TYR798B, VAL1007B, VAL1034B, VAL13J, VAL3J, VAL54J, VAL5J, VAL780B, VAL787B, VAL825B
• B-K: ALA3K, ALA48K, ALA69K, ARG1122B, ARG47K, ARG6K, ARG848B, ARG852B, ARG995B, ARG996B, ASN1074B, ASN2K, ASN44K, ASN842B, ASN946B, ASP1100B, ASP39K, ASP847B, ASP998B, GLN843B, GLN975B, GLU64K, GLU997B, GLY1075B, GLY1078B, GLY991B, HIS1076B, HIS1104B, HIS40K, HIS65K, ILE1103B, ILE846B, ILE976B, ILE990B, ILE992B, LEU45K, LEU9K, LYS1079B, MET1K, PHE10K, PHE67K, PHE68K, PRO4K, PRO66K, SER831B, SER844B, SER845B, THR1077B, THR41K, THR944B, THR993B, TYR61K, TYR833B, TYR994B, VAL1099B, VAL63K
• B-L: ALA111B, ALA117B, ALA32L, ALA45L, ALA59L, ALA69L, ALA900B, ARG120B, ARG42L, ARG47L, ARG54L, ARG60L, ARG63L, ARG70L, ARG848B, ARG852B, ARG904B, ARG967B, ARG969B, ASN103B, ASN957B, ASP106B, ASP44L, ASP847B, ASP891B, ASP894B, ASP895B, ASP896B, ASP950B, CYS31L, CYS34L, GLN115B, GLN66L, GLN951B, GLN958B, GLU104B, GLU116B, GLU33L, GLU68L, GLU863B, GLU875B, GLY107B, GLY52L, GLY849B, GLY897B, GLY902B, GLY960B, HIS110B, HIS53L, ILE30L, ILE55L, ILE846B, ILE899B, ILE911B, ILE912B, ILE948B, ILE973B, LEU112B, LEU119B, LEU122B, LEU192B, LEU40L, LEU56L, LEU57L, LEU64L, LEU893B, LEU898B, LEU953B, LEU961B, LYS191B, LYS193B, LYS28L, LYS58L, LYS62L, LYS876B, LYS892B, LYS934B, LYS962B, LYS965B, MET101B, MET789B, PHE67L, PHE874B, PHE963B, PRO901B, SER105B, SER35L, SER41L, THR109B, THR43L, THR61L, THR873B, THR889B, THR955B, THR956B, THR971B, TYR113B, TYR29L, TYR797B, TYR890B, VAL102B, VAL108B, VAL46L, VAL65L, VAL787B, VAL903B, VAL905B, VAL949B, VAL952B, VAL954B, VAL964B, VAL966B
• B-S: ASP118S, ASP166S, HIS1177B, LYS1183B
• C-H: ARG19H, ASN21H, ASN43H, ASP190C, ASP217C, ASP220C, ASP94H, GLU45H, GLY216C, HIS188C, LEU186C, LEU46H, LYS187C, LYS222C, LYS22H, PHE219C, PHE47H, PRO218C, PRO48H, THR189C, TYR191C, TYR193C, TYR221C, VAL44H
• C-J: ALA168C, ALA173C, ALA174C, ALA175C, ALA45C, ALA59C, ARG148C, ARG43J, ARG62J, ARG66C, ARG6J, ASN112C, ASN140C, ASN17C, ASN231C, ASN23J, ASN64J, ASP136C, ASP16C, ASP16J, ASP55J, CYS10J, CYS145C, CYS45J, CYS46J, CYS7J, GLN135C, GLN151C, GLU138C, GLU177C, GLU19J, GLU233C, GLU58J, GLY11J, GLY139C, GLY141C, GLY150C, GLY15J, GLY171C, GLY236C, GLY40J, GLY68C, HIS53J, HIS65C, ILE133C, ILE134C, ILE144C, ILE176C, ILE2J, ILE38C, ILE57J, ILE63C, ILE70C, LEU143C, LEU147C, LEU22J, LEU24J, LEU39J, LEU41J, LEU44C, LEU56J, LEU58C, LEU61J, LEU67C, LEU69C, LEU72C, LYS12J, LYS137C, LYS146C, LYS149C, LYS169C, LYS17J, LYS42J, LYS59J, MET1J, PHE60J, PHE62C, PHE8J, PRO172C, PRO4J, PRO65J, PRO71C, SER109C, SER115C, SER20J, SER234C, SER237C, SER9J, THR110C, THR111C, THR43C, THR55C, THR56C, TRP170C, TRP18J, TYR114C, TYR63J, VAL113C, VAL13J, VAL142C, VAL14J, VAL235C, VAL3J, VAL57C, VAL5J
• C-K: ALA100K, ALA13C, ALA164C, ALA168C, ALA256C, ALA261C, ALA28C, ALA30C, ALA39C, ALA48K, ALA69K, ALA86K, ALA90K, ARG11C, ARG246C, ARG34C, ARG35C, ARG47K, ARG6K, ARG84C, ASN104K, ASN110K, ASN17C, ASN24C, ASN31C, ASN44K, ASN52K, ASN89K, ASN92K, ASN96K, ASP16C, ASP19C, ASP241C, ASP249C, ASP266C, ASP268C, ASP26C, ASP39K, ASP5K, ASP85C, ASP85K, CYS91K, GLN112K, GLN224C, GLN242C, GLN252C, GLN264C, GLN267C, GLN7C, GLU106K, GLU108K, GLU12C, GLU166C, GLU36K, GLU38K, GLU3C, GLU40C, GLU49K, GLU4C, GLU8K, GLY162C, GLY247C, GLY43K, GLY5C, GLY99K, HIS167C, HIS40K, ILE10C, ILE163C, ILE21C, ILE21K, ILE248C, ILE258C, ILE33K, ILE46K, ILE75K, ILE94K, ILE95K, LEU101K, LEU111K, LEU114K, LEU11K, LEU12K, LEU19K, LEU22C, LEU251C, LEU259C, LEU260C, LEU262C, LEU27C, LEU33C, LEU42K, LEU45K, LEU51K, LEU73K, LEU87K, LEU98K, LEU9K, LYS102K, LYS15C, LYS165C, LYS169C, LYS18K, LYS20K, LYS253C, LYS254C, LYS37K, LYS84K, LYS88K, LYS97K, LYS9C, MET230C, MET265C, MET29C, MET37C, PHE105K, PHE10K, PHE20C, PHE228C, PHE35K, PHE71K, PHE7K, PRO239C, PRO6C, PRO83K, SER14C, SER17K, SER23C, SER257C, SER32C, SER93K, THR103K, THR107K, THR113K, THR250C, THR263C, THR34K, THR41K, TRP109K, TRP170C, TYR61K, TYR82C, VAL18C, VAL232C, VAL240C, VAL243C, VAL244C, VAL245C, VAL255C, VAL25C, VAL36C, VAL63K, VAL8C
• C-L: ALA159C, ALA164C, ALA168C, ALA45C, ALA59C, ALA59L, ALA64C, ALA69L, ARG60L, ARG63L, ARG66C, ARG70L, ARG84C, ASN54C, ASP47C, ASP60C, ASP90C, CYS157C, CYS34L, GLN66L, GLU166C, GLU33L, GLU50C, GLU52C, GLU61C, GLU68L, GLY162C, GLY68C, HIS167C, HIS65C, HIS91C, ILE163C, ILE30L, ILE46C, ILE63C, ILE70C, LEU153C, LEU155C, LEU64L, LEU67C, LEU69C, LYS149C, LYS154C, LYS160C, LYS161C, LYS165C, LYS169C, LYS62L, PHE62C, PHE67L, SER35L, SER48C, THR156C, THR53C, THR55C, THR56C, THR61L, TRP170C, VAL158C, VAL49C, VAL51C, VAL65L
• D-G: ALA178D, ALA184D, ALA188D, ALA191D, ALA24D, ALA25D, ALA49D, ALA55D, ALA62D, ALA69D, ALA76G, ARG119D, ARG142G, ARG144G, ARG153D, ARG21G, ARG56D, ARG66D, ARG67D, ARG68D, ARG72D, ARG75G, ASN10G, ASN137D, ASN138D, ASN143D, ASN150D, ASN23D, ASN39D, ASN51D, ASN53G, ASN71G, ASP140D, ASP166G, ASP186D, ASP189D, ASP50G, ASP52G, ASP55G, ASP6G, ASP88G, CYS150G, CYS185D, CYS38G, CYS47G, GLN102G, GLN146D, GLN179D, GLN24G, GLN28D, GLN31D, GLN34D, GLN37D, GLN41D, GLN57G, GLN74D, GLN9D, GLU165G, GLU176D, GLU190D, GLU21D, GLU22D, GLU32D, GLU32G, GLU33G, GLU35G, GLU43D, GLU45D, GLU46D, GLU54D, GLU61D, GLU65D, GLU69G, GLU85G, GLY104G, GLY135D, GLY136D, GLY149G, GLY169G, GLY30D, GLY36G, GLY40G, GLY42D, GLY43G, GLY84G, GLY89G, HIS173D, HIS40D, ILE11G, ILE143G, ILE147G, ILE157G, ILE171G, ILE195D, ILE38D, ILE45G, ILE48D, ILE4G, ILE54G, ILE59D, LEU123D, LEU130D, LEU141D, LEU148D, LEU168G, LEU180D, LEU183D, LEU194D, LEU27D, LEU29D, LEU30G, LEU31G, LEU46G, LEU47D, LEU49G, LEU50D, LEU52D, LEU57D, LEU63D, LEU7G, LEU9G, LYS107G, LYS139D, LYS140G, LYS142D, LYS146G, LYS192D, LYS27G, LYS36D, LYS41G, LYS5G, LYS60D, LYS71D, LYS73G, LYS76D, LYS80G, LYS83G, MET106G, MET145D, MET1G, PHE151D, PHE175D, PHE2G, PHE33D, PHE3G, PHE42G, PHE70D, PHE79G, PHE82G, PHE8D, PRO105G, PRO174D, PRO196D, PRO81G, SER141G, SER152D, SER155G, SER156G, SER182D, SER197D, SER37G, SER4D, SER53D, SER6D, SER73D, SER8G, THR10D, THR12G, THR133D, THR134D, THR144D, THR149D, THR187D, THR193D, THR26D, THR28G, THR39G, THR5D, THR7D, THR90G, TYR147D, TYR167G, TYR221D, TYR44G, TYR51G, TYR74G, VAL101G, VAL103G, VAL145G, VAL177D, VAL34G, VAL3D, VAL48G, VAL58D, VAL64D, VAL72G, VAL77G, VAL78G, VAL86G, VAL87G, VAL91G
• D-M: ALA188D, ALA33M, ALA87M, ARG209D, ARG28M, ARG36M, ARG57M, ASN199D, ASN200D, ASN273M, ASN282M, ASP186D, ASP189D, ASP204D, ASP205D, ASP85M, CYS238M, GLU190D, GLU206D, GLU208D, GLU213D, GLU25M, GLU277M, GLU280M, HIS281M, HIS83M, ILE202D, ILE210D, ILE274M, ILE35M, ILE84M, LEU211D, LEU279M, LEU86M, LYS192D, LYS212D, LYS34M, PHE37M, SER203D, THR187D, THR278M, VAL32M
• E-F: ALA73F, ALA80F, ARG167E, ARG169E, ARG79F, ASP140F, GLN174E, GLN78F, GLU144F, GLU71F, GLY141F, ILE74F, LEU138F, LEU170E, LYS171E, LYS72F, PHE143F, PRO139F, PRO75F, SER142F, THR81F, TYR168E
• F-G: ALA105F, ALA68G, ALA73F, ARG135F, ARG21G, ARG58G, ARG60G, ARG79F, ARG92F, ARG97F, ASN104F, ASN71G, ASP145F, ASP65G, GLN100F, GLN57G, GLU144F, GLU150F, GLY19G, GLY59G, GLY66G, HIS14G, ILE101F, ILE134F, ILE61G, ILE93F, LEU132F, LEU13G, LEU62G, LEU99F, LYS70F, LYS73G, LYS76F, MET103F, MET22G, PHE108F, PHE143F, PHE17G, PHE18G, PRO106F, PRO131F, PRO15G, PRO20G, PRO63G, SER102F, SER147F, SER16G, SER67G, THR64G, THR96F, TRP146F, TYR137F, VAL107F, VAL133F
• G-M: ARG57M, LYS34M, TYR167G
• G-N: ASP118G, HIS1177N
• G-S: GLU100G, GLU100S, HIS113G, HIS113S, HIS158G, HIS158S, HIS97G, HIS97S, LYS107G, LYS107S, LYS112S
• H-K: ALA27K, ALA84H, ARG54K, ARG74K, ARG77H, ARG80H, ARG87H, ASN29K, ASP53K, GLN76K, GLN83H, GLU79K, GLY85H, LEU51K, LEU57K, LYS55K, PHE58K, PRO28K, PRO81H, PRO82H, SER78H, THR77K, THR78K, TRP79H, VAL56K
• J-L: ALA32L, ASN64J, CYS31L, CYS34L, GLU33L, ILE30L, LEU57L, PRO65J, SER35L, SER36L
• K-L: ARG6K, ARG70L, ASP5K, PHE10K, PHE7K
• M-N: ALA1016N, ALA1024N, ALA1083N, ALA1149M, ALA1154N, ALA266N, ALA472N, ALA480M, ALA509N, ALA525N, ALA532N, ALA671M, ALA684M, ALA695N, ALA704N, ALA726N, ALA735N, ALA749M, ALA753N, ALA759M, ALA763M, ALA776M, ALA817M, ALA826N, ALA828M, ALA828N, ALA832M, ALA937N, ALA9M, ARG1020N, ARG1067N, ARG1106N, ARG1108N, ARG1129N, ARG1135N, ARG1150N, ARG1159N, ARG1215N, ARG1220N, ARG1222N, ARG12M, ARG261N, ARG267N, ARG320M, ARG328M, ARG335M, ARG337M, ARG344M, ARG350M, ARG469M, ARG47M, ARG498M, ARG512N, ARG620N, ARG635N, ARG63M, ARG677M, ARG728N, ARG730N, ARG766N, ARG782M, ARG806M, ARG821M, ARG839M, ARG884N, ARG935N, ASN1013N, ASN1074N, ASN1178N, ASN1211N, ASN1265M, ASN253M, ASN339M, ASN358M, ASN471M, ASN479M, ASN516N, ASN538N, ASN654M, ASN660M, ASN741M, ASN742M, ASN757M, ASN762N, ASN767N, ASN802M, ASN834N, ASP1136N, ASP1156N, ASP1219N, ASP1419M, ASP1420M, ASP346M, ASP356M, ASP394N, ASP397N, ASP399N, ASP481M, ASP483M, ASP485M, ASP526M, ASP544M, ASP618N, ASP668M, ASP672M, ASP694N, ASP724N, ASP760N, ASP781M, ASP790M, ASP791M, ASP826M, ASP837N, ASP936N, ASP978N, ASP998N, CYS1029N, CYS523N, CYS529M, CYS533N, CYS764M, CYS829N, GLN1065N, GLN1117N, GLN1193N, GLN18M, GLN256M, GLN313M, GLN316M, GLN469N, GLN493M, GLN4M, GLN513N, GLN525M, GLN531N, GLN545M, GLN5M, GLN650M, GLN706N, GLN745M, GLN760M, GLN763N, GLN768M, GLN811M, GLN835N, GLN843N, GLN975N, GLN986N, GLU1028N, GLU1053N, GLU1070N, GLU1120N, GLU1132N, GLU1134N, GLU1149N, GLU1151M, GLU1206N, GLU1264M, GLU1269M, GLU16M, GLU254M, GLU262N, GLU26M, GLU312N, GLU319N, GLU433M, GLU486M, GLU496M, GLU500M, GLU526N, GLU529N, GLU621N, GLU681M, GLU696N, GLU697N, GLU698N, GLU699N, GLU72M, GLU742N, GLU76M, GLU771M, GLU795M, GLU801M, GLU812M, GLU822M, GLU833M, GLU836N, GLU846M, GLY1068N, GLY1075N, GLY1127N, GLY1142N, GLY20M, GLY263N, GLY319M, GLY338M, GLY355M, GLY3M, GLY402N, GLY484M, GLY520N, GLY530M, GLY530N, GLY534N, GLY661M, GLY665M, GLY667M, GLY673M, GLY750M, GLY750N, GLY753M, GLY778M, GLY807M, GLY819M, GLY820M, GLY823M, GLY832N, GLY977N, GLY988N, GLY991N, HIS1015N, HIS1025N, HIS1076N, HIS1104N, HIS1141N, HIS1258M, HIS400N, HIS490M, HIS515N, HIS518N, HIS659M, HIS733N, HIS734N, HIS740N, HIS744N, HIS761N, HIS786M, HIS816M, HIS887N, HIS92M, ILE1011N, ILE1012N, ILE1017N, ILE1027N, ILE1050N, ILE1055N, ILE1263M, ILE353M, ILE463M, ILE523M, ILE531M, ILE619N, ILE666M, ILE670M, ILE679M, ILE683M, ILE693N, ILE701N, ILE703N, ILE729N, ILE748N, ILE756M, ILE756N, ILE758M, ILE775M, ILE825M, ILE827N, ILE840N, ILE918N, ILE976N, ILE990N, ILE992N, LEU1026N, LEU1030N, LEU1031N, LEU1059N, LEU1128N, LEU1151N, LEU1175N, LEU1268M, LEU1418M, LEU315M, LEU359M, LEU470M, LEU472M, LEU508N, LEU514N, LEU521N, LEU528M, LEU535N, LEU637N, LEU657M, LEU658M, LEU702N, LEU710N, LEU740M, LEU749N, LEU784M, LEU805M, LEU808M, LEU824M, LYS1079N, LYS1102M, LYS1102N, LYS1112M, LYS1144M, LYS1174N, LYS1261M, LYS1262M, LYS15M, LYS315N, LYS332M, LYS343M, LYS393N, LYS403M, LYS452M, LYS470N, LYS510N, LYS537N, LYS687M, LYS727N, LYS744M, LYS752M, LYS789M, LYS830M, LYS843M, LYS864N, LYS934N, LYS979N, LYS987N, MET1021N, MET1072N, MET1210N, MET455M, MET473N, MET676M, MET705N, MET746M, MET747N, MET761M, MET773N, MET818M, MET839N, MET885N, MET999N, PHE1047N, PHE1069N, PHE1130N, PHE1146N, PHE22M, PHE252M, PHE401N, PHE468M, PHE482M, PHE655M, PHE662M, PHE738N, PHE755M, PHE758N, PHE777M, PHE779M, PHE787M, PHE813M, PHE814M, PHE815M, PHE980N, PRO1000N, PRO1014N, PRO1018N, PRO1046N, PRO1099M, PRO10M, PRO321M, PRO357M, PRO464M, PRO511N, PRO524N, PRO528N, PRO725N, PRO745N, PRO759N, PRO765N, PRO785M, PRO794M, PRO810M, PRO917N, SER1019N, SER1056N, SER1066N, SER1145N, SER1150M, SER1221N, SER251M, SER255M, SER264N, SER265N, SER318M, SER348M, SER354M, SER466M, SER473M, SER476M, SER494M, SER540N, SER663M, SER700N, SER732N, SER746N, SER751M, SER754M, SER762M, SER764N, SER769M, SER788M, SER793M, SER796M, SER7M, SER803M, SER831N, SER838N, SER8M, SER919N, SER933N, THR1022N, THR1048N, THR1051N, THR1213N, THR1266M, THR1438M, THR351M, THR467M, THR475M, THR497M, THR517N, THR527M, THR527N, THR664M, THR669M, THR680M, THR736N, THR737N, THR739N, THR768N, THR783M, THR809M, THR827M, THR831M, THR916N, THR989N, THR993N, TRP308N, TRP519N, TRP552M, TRP656M, TYR1073N, TYR1192N, TYR1217N, TYR417M, TYR465M, TYR769N, TYR804M, TYR830N, TYR833N, TYR866N, TYR994N, VAL1023N, VAL1052N, VAL345M, VAL352M, VAL491M, VAL522N, VAL524M, VAL536N, VAL723N, VAL731N, VAL743M, VAL747M, VAL765M, VAL770M, VAL780M, VAL800M, VAL829M
• M-O: ASP190O, ASP538M, ASP672M, GLU194O, LYS569M, LYS738M, TYR221O
• M-P: ARG13P, ARG14P, GLU16M, GLU226M, LYS16P
• M-Q: ARG1012M, ARG1326M, ARG1345M, ARG167Q, ARG169Q, ARG177Q, ARG200Q, ARG207Q, ARG212Q, ARG857M, ASP1013M, ASP1323M, ASP182Q, ASP853M, ASP871M, GLN174Q, GLU1005M, GLU1342M, GLU148Q, GLU163Q, GLU203Q, GLU870M, GLU945M, HIS147Q, HIS153Q, ILE1341M, LYS201Q, PHE866M, SER205Q, THR1325M, THR1377M, THR204Q, TYR168Q, TYR208Q, VAL863M
• M-R: ARG1055M, ARG135R, ARG92R, ASP140R, ASP1442M, ASP1446M, ASP145R, ASP154R, ASP853M, ASP874M, GLU1062M, GLU149R, GLU496M, GLU500M, GLU89R, HIS1059M, HIS851M, LYS1452M, LYS87R, MET1444M, PRO131R, TYR852M, VAL133R
• M-S: ARG58S, ARG60S, ASP1442M, ASP1446M, ASP65S, GLU1447M, GLU1448M, GLU496M, ILE61S, LYS23S, VAL1443M
• M-T: ALA564M, ARG19T, ARG25T, ARG537M, ASP41T, ASP538M, ASP602M, ASP609M, ASP739M, ASP974M, GLU106T, GLU138T, GLU45T, GLY119T, GLY120T, HIS975M, ILE560M, ILE566M, LYS136T, LYS22T, LYS567M, LYS569M, LYS738M, SER573M, TRP79T, TYR98T, VAL96T
• M-U: ALA699M, ARG1194M, ARG45U, ARG711M, ARG91U, ASP1257M, ASP65U, ASP781M, ASP94U, GLN114U, GLN698M, GLN87U, GLU1151M, GLU1196M, GLU1256M, GLU1264M, GLU18U, GLU47U, GLU712M, HIS46U, ILE1152M, LYS789M, PRO41U, SER112U, SER1150M, THR67U, TYR1154M, TYR44U, VAL43U
• M-W: ARG47W, ASN2W, ASN548M, ASP356M, ASP544M, ASP555M, ASP557M, HIS65W, LYS26W, LYS461M, LYS62W, LYS651M, SER369M, TYR465M, TYR551M, TYR61W
• N-O: ALA1003N, ALA168O, ARG1060N, ARG1067N, ARG34O, ARG35O, ARG848N, ARG852N, ARG969N, ARG995N, ASN31O, ASP181O, ASP190O, ASP60O, ASP847N, ASP950N, ASP998N, GLU1004N, GLU166O, GLU177O, GLU179O, GLU194O, GLU200O, GLU40O, GLU61O, GLU997N, GLY1075N, HIS1076N, HIS167O, HIS188O, HIS65O, LYS1079N, LYS1080N, LYS165O, LYS169O, MET1082N, PHE178O, TYR180O
• N-P: ARG1215N, ARG13P, ASP1186N, ASP1190N, ASP1219N, LYS17P
• N-R: ASP1223N, ASP140R, LYS72R
• N-S: ASP1190N, LYS1148N, LYS41S, THR64S
• N-U: ARG30U, ARG392N, ARG617N, ARG620N, ARG91U, ARG92U, ASN12U, ASP294N, ASP391N, ASP394N, ASP576N, ASP618N, ASP61U, ASP65U, ASP94U, GLU312N, GLU319N, HIS46U, LYS393N, LYS622N, LYS93U, MET13U
• N-V: ARG43V, ARG48V, ARG62V, ARG6V, ARG848N, ARG996N, ASP1009N, CYS10V, GLU1004N, GLU1041N, GLU186N, GLU32V, GLU816N, LYS42V, LYS59V, PHE8V, SER9V
• N-W: ARG6W, ARG995N, ASP1100N, ASP39W, ASP847N, ASP998N, GLU997N, HIS1076N, HIS40W, MET1W
• N-X: ARG120N, ARG42X, ARG47X, ARG54X, ARG63X, ARG70X, ARG852N, ARG904N, ASP106N, ASP847N, ASP894N, ASP896N, GLN66X, GLU104N, GLU116N, GLU33X, GLU68X, GLU875N, GLY902N, HIS110N, HIS53X, ILE55X, LEU56X, LEU898N, LYS193N, LYS28X, LYS58X, LYS892N, LYS962N, THR61X, THR955N, VAL954N
• O-T: ASP190O, GLU45T, LYS187O, LYS22T
• O-V: ARG148O, ARG43V, ARG62V, ARG66O, ARG6V, ASN64V, ASP136O, ASP16O, ASP16V, ASP55V, GLU138O, GLU177O, GLU19V, GLU233O, GLU58V, LEU69O, LYS12V, LYS146O, LYS149O, LYS169O, LYS17V, LYS42V, VAL3V
• O-W: ARG35O, ARG6W, ASP241O, ASP249O, ASP266O, ASP26O, ASP39W, ASP5W, GLN252O, GLU106W, GLU108W, GLU166O, GLU38W, GLU3O, GLU40O, GLU49W, HIS167O, HIS40W, ILE95W, LYS102W, LYS165O, LYS18W, LYS254O, LYS84W, LYS97W, LYS9O, THR41W
• O-X: ALA69X, ARG60X, ARG70X, ASP47O, ASP60O, GLU166O, GLU52O, GLU61O, GLU68X, HIS167O, HIS65O, LYS169O, PHE67X, VAL49O, VAL51O, VAL65X
• P-S: ARG66P, ARG68P, ARG72P, ARG75S, ASP140P, ASP166S, ASP189P, ASP50S, ASP52S, ASP55S, ASP6S, ASP88S, GLN37P, GLU190P, GLU22P, GLU32P, GLU35S, GLU45P, GLU61P, GLU65P, HIS40P, ILE48P, ILE4S, LEU50P, LYS41S, LYS5S, LYS73S, LYS83S, PHE2S, SER8S, THR5P, TYR147P, TYR167S, VAL48S
• Q-R: ARG169Q, ASP140R, LYS171Q, SER142R
• R-S: ARG135R, ARG58S, ARG60S, ASP145R, GLN100R, GLY66S
• W-X: ARG6W, ARG70X