3HOB

factor viii trp2313-his2315 segment is involved in membrane binding as shown by crystal structure of complex between factor viii c2 domain and an inhibitor

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: M-A
  • Int. Res.: 56
  • Norm. En. per Res.: -1.3379
• Hub Node: M(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
M-A	-3.5161	3.3343	-74.7416	-74.9233	56	0	0	2898	0	13	12

Interface residues

• M-A: ALA2184A, ALA2188A, ALA2188M, ALA2192M, ARG2220M, ARG2304A, ARG2304M, ARG2307A, ARG2307M, ASN2198M, ASP2187A, ASP2233A, ASP2233M, ASP2267A, ASP2267M, GLN2189A, GLN2222M, GLN2231A, GLN2231M, GLN2235A, GLN2266A, GLN2270A, GLN2270M, GLU2228M, GLU2327A, GLY2268A, GLY2268M, HIS2269A, HIS2269M, HIS2309M, ILE2185A, ILE2190A, ILE2190M, LEU2178A, LYS2227M, LYS2236A, MET2238A, PHE2196M, PHE2234A, PRO2205M, PRO2221M, SER2186A, SER2193M, SER2194M, SER2204M, THR2191A, THR2191M, THR2197M, THR2202M, THR2237A, TRP2203M, TRP2229M, TRP2271M, TYR2195M, TYR2305A, TYR2305M