3HK9

crystal structure of uronate isomerase from bacillus halodurans complexed with zinc and d-glucuronate

• Total interactions analyzed: 66
• Total true interactions: 31
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 167
  • Norm. En. per Res.: -4.6492
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-87.0317	-65.8132	-545.894	-698.7389	166	18	8	21834	8	84	85
A-C	-96.7418	-77.5404	-569.883	-744.1652	167	21	8	22301	12	90	86
A-J	0.0	-13.7436	-34.5557	-48.2993	40	0	0	1473	1	16	18
A-K	-45.0934	11.5835	-88.001	-121.5109	35	7	0	3039	0	7	12
A-L	0.0	14.6924	-1.1327	13.5597	8	0	0	121	0	2	4
B-C	-99.7121	-68.664	-558.412	-726.7881	165	26	8	22201	10	87	86
B-D	-10.562	24.3105	-19.3549	-5.6064	32	3	0	753	0	20	20
B-F	0.0	1.1005	-0.5306	0.5699	5	0	0	55	0	3	5
B-J	0.0	0.0	-0.692	-0.692	12	0	0	89	0	2	1
B-L	-7.9373	-15.1573	-37.8216	-60.9162	42	0	0	1667	1	18	18
C-K	-5.4779	0.0	-17.2471	-22.725	29	0	0	969	0	10	9
C-L	-48.7431	9.1099	-87.582	-127.2152	34	4	0	3000	0	7	12
D-E	-100.8149	-82.7249	-551.097	-734.6368	166	21	8	22048	13	85	84
D-F	-90.5176	-76.7609	-559.937	-727.2155	166	27	8	22151	13	89	86
D-G	-9.6627	-16.8169	-37.3335	-63.8131	41	1	0	1550	1	17	18
D-H	-47.2194	10.7472	-80.5513	-117.0235	34	6	0	3011	0	7	12
D-I	0.0	15.3028	-1.4159	13.8869	8	0	0	140	0	2	4
E-F	-94.247	-72.1937	-547.047	-713.4878	166	23	8	22094	13	88	86
E-G	0.0	0.0	-1.2989	-1.2989	13	0	0	145	0	2	1
E-I	-12.4693	-22.1199	-37.2279	-71.8171	41	2	0	1659	2	17	18
F-H	-3.6911	0.0	-19.0309	-22.722	31	1	0	985	0	9	8
F-I	-44.5378	9.3946	-88.1283	-123.2715	35	3	0	3028	0	7	13
F-K	0.0	0.0	-0.0432	-0.0432	4	0	0	11	0	1	8
G-H	-116.7677	-80.8665	-563.212	-760.8461	166	23	8	22248	11	88	86
G-I	-97.103	-79.2769	-551.46	-727.8399	167	22	8	22112	12	86	85
G-K	0.0	1.3001	-0.9699	0.3303	6	0	0	85	0	2	5
G-L	0.0	24.1983	-17.2314	6.9669	32	3	0	582	0	18	20
H-I	-114.127	-102.6983	-559.585	-776.4103	167	19	8	22082	14	89	86
J-K	-110.4517	-53.4473	-564.454	-728.353	165	19	8	22172	8	87	86
J-L	-106.345	-85.2175	-559.813	-751.3756	169	28	8	22338	13	85	85
K-L	-107.2792	-78.2663	-567.731	-753.2765	166	21	8	22072	11	89	86

Interface residues

• A-B: ALA108A, ALA268A, ALA272A, ALA279A, ALA313B, ALA387B, ALA53A, ALA92A, ARG110A, ARG264A, ARG289B, ARG303A, ARG303B, ARG314B, ARG339B, ARG341B, ARG398B, ARG406B, ARG410B, ARG57A, ARG86A, ARG94A, ASN305A, ASN305B, ASN318B, ASN329A, ASN330A, ASN335A, ASN335B, ASN407B, ASN4B, ASP106A, ASP111A, ASP271A, ASP274A, ASP282B, ASP379B, ASP382B, ASP383B, ASP399B, ASP402B, CYS93A, CYS99A, GLN101A, GLN306B, GLN386B, GLU285B, GLU304A, GLU304B, GLU308B, GLU332A, GLU332B, GLU336A, GLU336B, GLU343B, GLU390B, GLU395B, GLU54A, GLU80A, GLU81A, GLU91A, GLY102A, GLY270A, GLY273A, GLY277A, GLY346B, GLY388B, GLY95A, HIS266A, HIS286B, HIS307B, HIS367A, HIS368A, HIS49A, ILE321B, ILE333A, ILE333B, ILE334A, ILE350B, ILE372A, ILE378B, ILE384B, ILE396B, ILE3B, ILE63A, ILE84A, LEU100A, LEU105A, LEU112A, LEU269A, LEU288B, LEU301A, LEU309B, LEU312B, LEU319B, LEU345B, LEU377B, LEU385B, LEU403B, LEU51A, LEU82A, LEU97A, LEU9B, LYS262A, LYS263A, LYS278A, LYS278B, LYS315B, LYS380B, LYS85A, MET281B, MET320B, MET328A, MET337B, MET340B, MET342B, MET344B, MET56A, PHE275A, PHE316B, PHE327A, PHE349B, PHE411B, PHE83A, PRO107A, PRO267A, PRO292B, PRO331A, PRO88A, SER280B, SER2B, SER302A, SER302B, SER317B, SER348B, SER62A, SER87A, SER90A, THR109A, THR338B, THR347B, THR392B, THR59A, THR98A, TRP325A, TRP326A, TRP389B, TRP58A, TRP79A, TYR115A, TYR364A, TYR381B, TYR48A, TYR50A, VAL261A, VAL265A, VAL276A, VAL284B, VAL310B, VAL311B, VAL376B, VAL391B, VAL52A, VAL55A, VAL89A, VAL96A
• A-C: ALA108C, ALA268C, ALA272C, ALA279C, ALA313A, ALA387A, ALA53C, ALA92C, ARG110C, ARG264C, ARG289A, ARG303A, ARG303C, ARG314A, ARG339A, ARG341A, ARG398A, ARG406A, ARG410A, ARG57C, ARG86C, ARG94C, ASN305A, ASN305C, ASN318A, ASN329C, ASN330C, ASN335A, ASN335C, ASN407A, ASP106C, ASP111C, ASP271C, ASP274C, ASP282A, ASP379A, ASP382A, ASP383A, ASP399A, ASP402A, ASP60C, CYS93C, CYS99C, GLN101C, GLN306A, GLN386A, GLU285A, GLU290A, GLU304A, GLU304C, GLU308A, GLU332A, GLU332C, GLU336A, GLU336C, GLU343A, GLU390A, GLU395A, GLU54C, GLU80C, GLU81C, GLU91C, GLY102C, GLY270C, GLY273C, GLY277C, GLY283A, GLY346A, GLY388A, GLY95C, HIS266C, HIS286A, HIS307A, HIS367C, HIS368C, HIS49C, ILE321A, ILE333A, ILE333C, ILE334C, ILE350A, ILE372C, ILE384A, ILE396A, ILE63C, ILE84C, LEU100C, LEU105C, LEU269C, LEU288A, LEU297A, LEU301C, LEU309A, LEU312A, LEU319A, LEU345A, LEU377A, LEU385A, LEU403A, LEU51C, LEU82C, LEU97C, LEU9A, LYS262C, LYS263C, LYS278A, LYS278C, LYS315A, LYS380A, LYS85C, MET281A, MET320A, MET328A, MET328C, MET337A, MET340A, MET342A, MET344A, MET56C, PHE275C, PHE296A, PHE316A, PHE327C, PHE349A, PHE411A, PHE83C, PRO107C, PRO267C, PRO292A, PRO331C, PRO88C, SER280A, SER302A, SER302C, SER317A, SER348A, SER62C, SER87C, SER90C, THR109C, THR338A, THR347A, THR392A, THR59C, THR98C, TRP325C, TRP326C, TRP389A, TRP58C, TRP79C, TYR115C, TYR364C, TYR381A, TYR48C, TYR50C, VAL261C, VAL265C, VAL276C, VAL284A, VAL310A, VAL311A, VAL376A, VAL391A, VAL52C, VAL55C, VAL89C, VAL96C
• A-J: ALA10A, ALA10J, ALA16A, ALA374A, ARG6J, ASN136A, ASN15A, ASN15J, ASN18A, ASN19A, ASN4J, GLN101A, GLN101J, GLU11A, GLU11J, GLU390J, GLU393A, GLU7J, GLY102A, GLY104A, HIS367A, HIS367J, ILE378J, LEU103A, LEU105A, LEU134A, LEU385J, LYS12A, LYS12J, LYS14A, LYS14J, LYS370A, SER2A, SER2J, SER371A, SER5J, THR98A, VAL17A, VAL8A, VAL8J
• A-K: ALA10K, ALA387A, ALA387K, ARG6A, ARG6K, ASN4A, ASN4K, ASP382A, ASP382K, ASP383K, GLN386A, GLN386K, GLU390A, GLU7A, GLU7K, GLY388A, GLY388K, ILE378K, ILE384A, ILE384K, ILE3A, ILE3K, LEU385A, LEU385K, LEU9A, LEU9K, SER2A, SER2K, SER5A, SER5K, TRP389A, TYR381K, VAL391A, VAL8A, VAL8K
• A-L: ALA108A, ALA108L, ASP106A, ASP106L, GLY104A, GLY104L, THR109A, THR109L
• B-C: ALA108B, ALA268B, ALA272B, ALA279B, ALA313C, ALA387C, ALA53B, ALA92B, ARG110B, ARG264B, ARG289C, ARG303B, ARG303C, ARG314C, ARG339C, ARG341C, ARG398C, ARG406C, ARG410C, ARG57B, ARG86B, ARG94B, ASN305B, ASN305C, ASN318C, ASN329B, ASN330B, ASN335B, ASN335C, ASN407C, ASP106B, ASP111B, ASP271B, ASP274B, ASP282C, ASP379C, ASP382C, ASP383C, ASP399C, ASP402C, ASP60B, CYS93B, CYS99B, GLN101B, GLN306C, GLN386C, GLU285C, GLU290C, GLU304B, GLU304C, GLU308C, GLU332B, GLU332C, GLU336B, GLU336C, GLU343C, GLU390C, GLU395C, GLU54B, GLU80B, GLU81B, GLU91B, GLY102B, GLY270B, GLY273B, GLY277B, GLY346C, GLY388C, GLY95B, HIS266B, HIS286C, HIS307C, HIS367B, HIS368B, HIS49B, ILE321C, ILE333B, ILE333C, ILE334B, ILE350C, ILE372B, ILE384C, ILE396C, ILE63B, ILE84B, LEU100B, LEU105B, LEU112B, LEU269B, LEU288C, LEU297C, LEU301B, LEU309C, LEU312C, LEU319C, LEU345C, LEU377C, LEU385C, LEU403C, LEU51B, LEU82B, LEU97B, LYS262B, LYS263B, LYS278B, LYS278C, LYS315C, LYS380C, LYS85B, MET281C, MET320C, MET328B, MET337C, MET340C, MET342C, MET344C, MET56B, PHE275B, PHE316C, PHE327B, PHE349C, PHE411C, PHE83B, PRO107B, PRO267B, PRO292C, PRO331B, PRO88B, SER280C, SER2C, SER302B, SER302C, SER317C, SER348C, SER62B, SER87B, SER90B, THR109B, THR338C, THR347C, THR392C, THR59B, THR98B, TRP325B, TRP326B, TRP389C, TRP58B, TRP79B, TYR115B, TYR364B, TYR381C, TYR48B, TYR50B, VAL261B, VAL265B, VAL276B, VAL284C, VAL310C, VAL311C, VAL376C, VAL391C, VAL52B, VAL55B, VAL89B, VAL96B
• B-D: ARG164B, ARG241D, ARG289D, ASN197D, ASN293D, ASN33B, ASP129B, ASP162B, ASP242D, GLN133B, GLN160B, GLN202D, GLU125B, GLU126B, GLU198D, GLU249D, GLU290D, GLY199D, ILE201D, LYS121B, LYS122B, LYS205D, LYS250D, PHE165B, PRO161B, PRO246D, PRO292D, SER163B, SER31B, THR123B, THR130B, TYR291D
• B-F: ALA268F, GLU117B, GLU64F, ILE63F, LYS121B
• B-J: ALA387B, ALA387J, ARG6B, ARG6J, ASN4B, ASN4J, GLN386B, GLN386J, GLY388B, GLY388J, SER5B, SER5J
• B-L: ALA10B, ALA10L, ALA16L, ALA374L, ARG6B, ASN15B, ASN15L, ASN18B, ASN18L, ASN19L, ASN4B, GLN101B, GLN101L, GLU11B, GLU11L, GLU390B, GLU393L, GLU7B, GLU7L, GLY102L, GLY104L, HIS367B, HIS367L, ILE378B, ILE378L, LEU103L, LEU134L, LEU385B, LYS12B, LYS12L, LYS14B, LYS14L, LYS370L, LYS397L, SER2B, SER2L, SER371L, SER5B, THR98L, VAL17L, VAL8B, VAL8L
• C-K: ALA108C, ALA108K, ASN4C, ASN4K, ASP106C, ASP106K, GLN101C, GLN101K, GLU390C, GLU390K, GLY104C, GLY104K, ILE3C, ILE3K, LEU105C, LEU105K, LEU97C, LYS12C, LYS12K, PRO107C, PRO107K, SER2C, SER2K, SER5C, SER5K, THR109C, THR109K, VAL8C, VAL8K
• C-L: ALA10C, ALA387C, ALA387L, ARG6C, ARG6L, ASN4C, ASN4L, ASP382C, ASP382L, ASP383C, GLN386C, GLN386L, GLU390L, GLU7C, GLU7L, GLY388C, GLY388L, ILE384C, ILE384L, ILE3C, ILE3L, LEU385C, LEU385L, LEU9C, LEU9L, SER2C, SER2L, SER5C, SER5L, TRP389L, TYR381C, VAL391L, VAL8C, VAL8L
• D-E: ALA108D, ALA268D, ALA272D, ALA279D, ALA313E, ALA387E, ALA53D, ALA92D, ARG110D, ARG264D, ARG289E, ARG303D, ARG303E, ARG314E, ARG339E, ARG341E, ARG398E, ARG406E, ARG410E, ARG57D, ARG86D, ARG94D, ASN305D, ASN305E, ASN318E, ASN329D, ASN330D, ASN335D, ASN335E, ASN407E, ASN4E, ASP106D, ASP111D, ASP271D, ASP274D, ASP282E, ASP379E, ASP382E, ASP383E, ASP399E, ASP402E, CYS93D, CYS99D, GLN101D, GLN306E, GLN386E, GLU285E, GLU290E, GLU304D, GLU304E, GLU308E, GLU332D, GLU332E, GLU336D, GLU336E, GLU343E, GLU390E, GLU395E, GLU54D, GLU80D, GLU81D, GLU91D, GLY102D, GLY270D, GLY273D, GLY277D, GLY283E, GLY346E, GLY388E, GLY95D, HIS266D, HIS286E, HIS307E, HIS367D, HIS368D, HIS49D, ILE321E, ILE333D, ILE333E, ILE334D, ILE350E, ILE372D, ILE378E, ILE384E, ILE396E, ILE3E, ILE63D, ILE84D, LEU100D, LEU105D, LEU112D, LEU269D, LEU288E, LEU301D, LEU309E, LEU312E, LEU319E, LEU345E, LEU377E, LEU385E, LEU403E, LEU51D, LEU82D, LEU97D, LYS262D, LYS263D, LYS278D, LYS278E, LYS315E, LYS380E, LYS85D, MET281E, MET320E, MET328D, MET337E, MET340E, MET342E, MET344E, MET56D, PHE275D, PHE316E, PHE327D, PHE349E, PHE411E, PHE83D, PRO107D, PRO267D, PRO292E, PRO331D, PRO88D, SER280E, SER2E, SER302D, SER302E, SER317E, SER348E, SER87D, SER90D, THR109D, THR338E, THR347E, THR392E, THR59D, THR98D, TRP325D, TRP326D, TRP389E, TRP58D, TRP79D, TYR115D, TYR364D, TYR381E, TYR48D, TYR50D, VAL261D, VAL265D, VAL276D, VAL284E, VAL310E, VAL311E, VAL376E, VAL391E, VAL52D, VAL55D, VAL89D, VAL96D
• D-F: ALA108F, ALA268F, ALA272F, ALA279F, ALA313D, ALA387D, ALA53F, ALA92F, ARG110F, ARG264F, ARG289D, ARG303D, ARG303F, ARG314D, ARG339D, ARG341D, ARG398D, ARG406D, ARG410D, ARG57F, ARG86F, ARG94F, ASN305D, ASN305F, ASN318D, ASN329F, ASN330F, ASN335D, ASN335F, ASN407D, ASP106F, ASP111F, ASP271F, ASP274F, ASP282D, ASP379D, ASP382D, ASP383D, ASP399D, ASP402D, CYS93F, CYS99F, GLN101F, GLN306D, GLN386D, GLU285D, GLU290D, GLU304D, GLU304F, GLU308D, GLU332D, GLU332F, GLU336D, GLU336F, GLU343D, GLU390D, GLU395D, GLU54F, GLU80F, GLU81F, GLU91F, GLY102F, GLY270F, GLY273F, GLY277F, GLY346D, GLY388D, GLY95F, HIS266F, HIS286D, HIS307D, HIS367F, HIS368F, HIS49F, ILE321D, ILE333D, ILE333F, ILE334F, ILE350D, ILE372F, ILE384D, ILE396D, ILE63F, ILE84F, LEU100F, LEU105F, LEU112F, LEU269F, LEU288D, LEU301F, LEU309D, LEU312D, LEU319D, LEU345D, LEU377D, LEU385D, LEU403D, LEU46F, LEU51F, LEU82F, LEU97F, LEU9D, LYS262F, LYS263F, LYS278D, LYS278F, LYS315D, LYS380D, LYS85F, MET281D, MET320D, MET328F, MET337D, MET337F, MET340D, MET342D, MET344D, MET56F, PHE275F, PHE296D, PHE316D, PHE327F, PHE349D, PHE411D, PHE83F, PRO107F, PRO267F, PRO292D, PRO331F, PRO88F, SER280D, SER302D, SER302F, SER317D, SER348D, SER62F, SER87F, SER90F, THR109F, THR338D, THR347D, THR392D, THR59F, THR98F, TRP325F, TRP326F, TRP389D, TRP58F, TRP79F, TYR115F, TYR364F, TYR381D, TYR48F, TYR50F, VAL261F, VAL265F, VAL276F, VAL284D, VAL310D, VAL311D, VAL376D, VAL391D, VAL52F, VAL55F, VAL89F, VAL96F
• D-G: ALA10D, ALA10G, ALA16D, ALA374D, ARG6G, ASN136D, ASN15D, ASN15G, ASN18D, ASN18G, ASN19D, ASN4G, ASP106D, GLN101D, GLN101G, GLU11D, GLU11G, GLU390G, GLU393D, GLU7G, GLY102D, GLY104D, HIS367D, HIS367G, ILE378G, LEU134D, LEU385G, LYS12D, LYS12G, LYS14D, LYS14G, LYS370D, LYS397D, SER2D, SER2G, SER371D, SER5G, THR98D, VAL17D, VAL8D, VAL8G
• D-H: ALA387D, ALA387H, ARG6D, ARG6H, ASN4D, ASN4H, ASP382D, ASP382H, ASP383H, GLN386D, GLN386H, GLU390D, GLU7D, GLU7H, GLY388D, GLY388H, ILE378H, ILE384D, ILE384H, ILE3D, ILE3H, LEU385D, LEU385H, LEU9D, LEU9H, SER2D, SER2H, SER5D, SER5H, TRP389D, TYR381H, VAL391D, VAL8D, VAL8H
• D-I: ALA108D, ALA108I, ASP106D, ASP106I, GLY104D, GLY104I, THR109D, THR109I
• E-F: ALA108E, ALA268E, ALA272E, ALA279E, ALA313F, ALA387F, ALA53E, ALA92E, ARG110E, ARG264E, ARG289F, ARG303E, ARG303F, ARG314F, ARG339F, ARG341F, ARG398F, ARG406F, ARG410F, ARG57E, ARG86E, ARG94E, ASN305E, ASN305F, ASN318F, ASN329E, ASN330E, ASN335E, ASN335F, ASN407F, ASP106E, ASP111E, ASP271E, ASP274E, ASP282F, ASP379F, ASP382F, ASP383F, ASP399F, ASP402F, ASP60E, CYS93E, CYS99E, GLN101E, GLN306F, GLN386F, GLU285F, GLU290F, GLU304E, GLU304F, GLU308F, GLU332E, GLU332F, GLU336E, GLU336F, GLU343F, GLU390F, GLU395F, GLU54E, GLU80E, GLU81E, GLU91E, GLY102E, GLY270E, GLY273E, GLY277E, GLY283F, GLY346F, GLY388F, GLY95E, HIS266E, HIS286F, HIS307F, HIS367E, HIS368E, HIS49E, ILE321F, ILE333E, ILE333F, ILE334E, ILE350F, ILE372E, ILE384F, ILE396F, ILE63E, ILE84E, LEU100E, LEU105E, LEU112E, LEU269E, LEU288F, LEU297F, LEU301E, LEU309F, LEU312F, LEU319F, LEU345F, LEU377F, LEU385F, LEU403F, LEU51E, LEU82E, LEU97E, LYS262E, LYS263E, LYS278E, LYS278F, LYS315F, LYS380F, LYS85E, MET281F, MET320F, MET328E, MET337F, MET340F, MET342F, MET344F, MET56E, PHE275E, PHE316F, PHE327E, PHE349F, PHE411F, PHE83E, PRO107E, PRO267E, PRO292F, PRO331E, PRO88E, SER280F, SER2F, SER302E, SER302F, SER317F, SER348F, SER62E, SER87E, SER90E, THR109E, THR338F, THR347F, THR392F, THR59E, THR98E, TRP325E, TRP326E, TRP389F, TRP58E, TRP79E, TYR115E, TYR364E, TYR381F, TYR48E, TYR50E, VAL261E, VAL265E, VAL276E, VAL284F, VAL310F, VAL311F, VAL376F, VAL391F, VAL52E, VAL55E, VAL89E, VAL96E
• E-G: ALA387E, ALA387G, ARG6E, ARG6G, ASN4E, ASN4G, GLN386E, GLN386G, GLY388E, GLY388G, LEU385E, SER5E, SER5G
• E-I: ALA10E, ALA10I, ALA16I, ALA374I, ARG6E, ASN136I, ASN15E, ASN15I, ASN18E, ASN18I, ASN19I, ASN4E, ASP106I, GLN101E, GLN101I, GLU11E, GLU11I, GLU390E, GLU7E, GLU7I, GLY102I, GLY104I, HIS367E, HIS367I, ILE378E, ILE378I, LEU134I, LEU385E, LYS12E, LYS12I, LYS14E, LYS14I, LYS370I, SER2E, SER2I, SER371I, SER5E, THR98I, VAL17I, VAL8E, VAL8I
• F-H: ALA108F, ALA108H, ASN4F, ASN4H, ASP106F, ASP106H, GLN101F, GLN101H, GLU11H, GLU390F, GLU390H, GLY104F, GLY104H, ILE3F, ILE3H, LEU105F, LEU105H, LEU97F, LYS12F, LYS12H, LYS14F, PRO107F, PRO107H, SER2F, SER2H, SER5F, SER5H, THR109F, THR109H, VAL8F, VAL8H
• F-I: ALA10F, ALA387F, ALA387I, ARG6F, ARG6I, ASN4F, ASN4I, ASP382F, ASP382I, ASP383F, GLN386F, GLN386I, GLU390I, GLU7F, GLU7I, GLY388F, GLY388I, ILE378F, ILE384F, ILE384I, ILE3F, ILE3I, LEU385F, LEU385I, LEU9F, LEU9I, SER2F, SER2I, SER5F, SER5I, TRP389I, TYR381F, VAL391I, VAL8F, VAL8I
• F-K: GLN113F, GLN113K, GLU73F, GLU73K
• G-H: ALA108G, ALA268G, ALA272G, ALA279G, ALA313H, ALA387H, ALA53G, ALA92G, ARG110G, ARG264G, ARG289H, ARG303G, ARG303H, ARG314H, ARG339H, ARG341H, ARG398H, ARG406H, ARG410H, ARG57G, ARG86G, ARG94G, ASN305G, ASN305H, ASN318H, ASN329G, ASN330G, ASN335G, ASN335H, ASN407H, ASP106G, ASP111G, ASP271G, ASP274G, ASP282H, ASP379H, ASP382H, ASP383H, ASP399H, ASP402H, ASP60G, CYS93G, CYS99G, GLN101G, GLN306H, GLN386H, GLU285H, GLU290H, GLU304G, GLU304H, GLU308H, GLU332G, GLU332H, GLU336G, GLU336H, GLU343H, GLU390H, GLU395H, GLU54G, GLU80G, GLU81G, GLU91G, GLY102G, GLY270G, GLY273G, GLY277G, GLY346H, GLY388H, GLY95G, HIS266G, HIS286H, HIS307H, HIS367G, HIS368G, HIS49G, ILE321H, ILE333G, ILE333H, ILE334G, ILE350H, ILE372G, ILE384H, ILE396H, ILE63G, ILE84G, LEU100G, LEU105G, LEU112G, LEU269G, LEU288H, LEU297H, LEU301G, LEU309H, LEU312H, LEU319H, LEU345H, LEU377H, LEU385H, LEU403H, LEU51G, LEU82G, LEU97G, LYS262G, LYS263G, LYS278G, LYS278H, LYS315H, LYS380H, LYS397H, LYS85G, MET281H, MET320H, MET328G, MET337H, MET340H, MET342H, MET344H, MET56G, PHE275G, PHE316H, PHE327G, PHE349H, PHE411H, PHE83G, PRO107G, PRO267G, PRO292H, PRO331G, PRO88G, SER280H, SER2H, SER302G, SER302H, SER317H, SER348H, SER87G, SER90G, THR109G, THR338H, THR347H, THR392H, THR59G, THR98G, TRP325G, TRP326G, TRP389H, TRP58G, TRP79G, TYR115G, TYR364G, TYR381H, TYR48G, TYR50G, VAL261G, VAL265G, VAL276G, VAL284H, VAL310H, VAL311H, VAL376H, VAL391H, VAL400H, VAL52G, VAL55G, VAL89G, VAL96G
• G-I: ALA108I, ALA268I, ALA272I, ALA279I, ALA313G, ALA387G, ALA53I, ALA92I, ARG110I, ARG264I, ARG289G, ARG303G, ARG303I, ARG314G, ARG339G, ARG341G, ARG398G, ARG406G, ARG410G, ARG57I, ARG86I, ARG94I, ASN305G, ASN305I, ASN318G, ASN329I, ASN330I, ASN335G, ASN335I, ASN407G, ASN4G, ASP106I, ASP111I, ASP271I, ASP274I, ASP282G, ASP379G, ASP382G, ASP383G, ASP399G, ASP402G, ASP60I, CYS93I, CYS99I, GLN101I, GLN306G, GLN386G, GLU285G, GLU290G, GLU304G, GLU304I, GLU308G, GLU332G, GLU332I, GLU336G, GLU336I, GLU343G, GLU390G, GLU395G, GLU54I, GLU80I, GLU81I, GLU91I, GLY102I, GLY270I, GLY273I, GLY277I, GLY346G, GLY388G, GLY95I, HIS266I, HIS286G, HIS307G, HIS367I, HIS368I, HIS49I, ILE321G, ILE333G, ILE333I, ILE334I, ILE350G, ILE372I, ILE384G, ILE396G, ILE3G, ILE84I, LEU100I, LEU105I, LEU112I, LEU269I, LEU288G, LEU301I, LEU309G, LEU312G, LEU319G, LEU345G, LEU377G, LEU385G, LEU403G, LEU51I, LEU82I, LEU97I, LYS262I, LYS263I, LYS278G, LYS278I, LYS315G, LYS380G, LYS397G, LYS85I, MET281G, MET320G, MET328I, MET337G, MET340G, MET342G, MET344G, MET56I, PHE275I, PHE316G, PHE327I, PHE349G, PHE411G, PHE83I, PRO107I, PRO267I, PRO292G, PRO331I, PRO88I, SER280G, SER2G, SER302G, SER302I, SER317G, SER348G, SER371I, SER87I, SER90I, THR109I, THR338G, THR347G, THR392G, THR59I, THR98I, TRP325I, TRP326I, TRP389G, TRP58I, TRP79I, TYR115I, TYR364I, TYR381G, TYR48I, TYR50I, VAL261I, VAL265I, VAL276I, VAL284G, VAL310G, VAL311G, VAL376G, VAL391G, VAL400G, VAL52I, VAL55I, VAL89I, VAL96I
• G-K: ALA268K, GLU117G, GLU64K, ILE63K, LYS121G, VAL114G
• G-L: ARG164G, ARG241L, ARG289L, ASN197L, ASN293L, ASN33G, ASP129G, ASP162G, ASP242L, GLN133G, GLN160G, GLN202L, GLU125G, GLU126G, GLU195L, GLU198L, GLU249L, GLU290L, GLY199L, ILE201L, LYS121G, LYS205L, LYS250L, PHE165G, PRO161G, PRO246L, PRO292L, SER163G, SER31G, THR123G, THR130G, TYR291L
• H-I: ALA108H, ALA268H, ALA272H, ALA279H, ALA313I, ALA387I, ALA53H, ALA92H, ARG110H, ARG264H, ARG289I, ARG303H, ARG303I, ARG314I, ARG339I, ARG341I, ARG398I, ARG406I, ARG410I, ARG57H, ARG86H, ARG94H, ASN305H, ASN305I, ASN318I, ASN329H, ASN330H, ASN335H, ASN335I, ASN407I, ASP106H, ASP111H, ASP271H, ASP274H, ASP282I, ASP379I, ASP382I, ASP383I, ASP399I, ASP402I, ASP60H, CYS93H, CYS99H, GLN101H, GLN306I, GLN386I, GLU285I, GLU290I, GLU304H, GLU304I, GLU308I, GLU332H, GLU332I, GLU336H, GLU336I, GLU343I, GLU390I, GLU395I, GLU54H, GLU80H, GLU81H, GLU91H, GLY102H, GLY270H, GLY273H, GLY277H, GLY346I, GLY388I, GLY95H, HIS266H, HIS286I, HIS307I, HIS367H, HIS368H, HIS49H, ILE321I, ILE333H, ILE333I, ILE334H, ILE350I, ILE372H, ILE384I, ILE396I, ILE84H, LEU100H, LEU105H, LEU112H, LEU269H, LEU288I, LEU297I, LEU301H, LEU309I, LEU312I, LEU319I, LEU345I, LEU377I, LEU385I, LEU403I, LEU46H, LEU51H, LEU82H, LEU97H, LEU9I, LYS262H, LYS263H, LYS278H, LYS278I, LYS315I, LYS380I, LYS397I, LYS85H, MET281I, MET320I, MET328H, MET337I, MET340I, MET342I, MET344I, MET56H, PHE275H, PHE296I, PHE316I, PHE327H, PHE349I, PHE411I, PHE83H, PRO107H, PRO267H, PRO292I, PRO331H, PRO88H, SER280I, SER302H, SER302I, SER317I, SER348I, SER87H, SER90H, THR109H, THR338I, THR347I, THR392I, THR59H, THR98H, TRP325H, TRP326H, TRP389I, TRP58H, TRP79H, TYR115H, TYR364H, TYR381I, TYR48H, TYR50H, VAL261H, VAL265H, VAL276H, VAL284I, VAL310I, VAL311I, VAL376I, VAL391I, VAL400I, VAL52H, VAL55H, VAL89H, VAL96H
• J-K: ALA108J, ALA268J, ALA272J, ALA279J, ALA313K, ALA387K, ALA53J, ALA92J, ARG110J, ARG264J, ARG289K, ARG303J, ARG303K, ARG314K, ARG339K, ARG341K, ARG398K, ARG406K, ARG410K, ARG57J, ARG86J, ARG94J, ASN305J, ASN305K, ASN318K, ASN329J, ASN330J, ASN335J, ASN335K, ASN407K, ASP106J, ASP111J, ASP271J, ASP274J, ASP282K, ASP379K, ASP382K, ASP383K, ASP399K, ASP402K, ASP60J, CYS93J, CYS99J, GLN101J, GLN306K, GLN386K, GLU285K, GLU290K, GLU304J, GLU304K, GLU308K, GLU332J, GLU332K, GLU336J, GLU336K, GLU343K, GLU390K, GLU395K, GLU54J, GLU80J, GLU81J, GLU91J, GLY102J, GLY270J, GLY273J, GLY277J, GLY346K, GLY388K, GLY95J, HIS266J, HIS286K, HIS307K, HIS367J, HIS368J, HIS49J, ILE321K, ILE333J, ILE333K, ILE334J, ILE350K, ILE372J, ILE384K, ILE396K, ILE63J, ILE84J, LEU100J, LEU105J, LEU269J, LEU288K, LEU301J, LEU309K, LEU312K, LEU319K, LEU345K, LEU377K, LEU385K, LEU403K, LEU51J, LEU82J, LEU97J, LYS262J, LYS263J, LYS278J, LYS278K, LYS315K, LYS380K, LYS397K, LYS85J, MET281K, MET320K, MET328J, MET337K, MET340J, MET340K, MET342K, MET344K, MET56J, PHE275J, PHE316K, PHE327J, PHE349K, PHE411K, PHE83J, PRO107J, PRO267J, PRO292K, PRO331J, PRO88J, SER280K, SER2K, SER302J, SER302K, SER317K, SER348K, SER87J, SER90J, THR109J, THR338K, THR347K, THR392K, THR59J, THR98J, TRP325J, TRP326J, TRP389K, TRP58J, TRP79J, TYR115J, TYR364J, TYR381K, TYR48J, TYR50J, VAL261J, VAL265J, VAL276J, VAL284K, VAL310K, VAL311K, VAL376K, VAL391K, VAL400K, VAL52J, VAL55J, VAL89J, VAL96J
• J-L: ALA108L, ALA268L, ALA272L, ALA279L, ALA313J, ALA387J, ALA53L, ALA92L, ARG110L, ARG264L, ARG289J, ARG303J, ARG303L, ARG314J, ARG339J, ARG341J, ARG398J, ARG406J, ARG410J, ARG57L, ARG86L, ARG94L, ASN305J, ASN305L, ASN318J, ASN329L, ASN330L, ASN335J, ASN335L, ASN407J, ASN4J, ASP106L, ASP111L, ASP271L, ASP274L, ASP282J, ASP379J, ASP382J, ASP383J, ASP399J, ASP402J, ASP60L, CYS93L, CYS99L, GLN101L, GLN306J, GLN386J, GLU285J, GLU290J, GLU304J, GLU304L, GLU308J, GLU332J, GLU332L, GLU336J, GLU336L, GLU343J, GLU390J, GLU395J, GLU54L, GLU80L, GLU81L, GLU91L, GLY102L, GLY270L, GLY273L, GLY277L, GLY346J, GLY388J, GLY95L, HIS266L, HIS286J, HIS307J, HIS367L, HIS368L, HIS49L, ILE321J, ILE333J, ILE333L, ILE334L, ILE350J, ILE372L, ILE384J, ILE396J, ILE3J, ILE63L, ILE84L, LEU100L, LEU105L, LEU112L, LEU269L, LEU288J, LEU301L, LEU309J, LEU312J, LEU319J, LEU345J, LEU377J, LEU385J, LEU403J, LEU51L, LEU82L, LEU97L, LYS262L, LYS263L, LYS278J, LYS278L, LYS315J, LYS380J, LYS397J, LYS85L, MET281J, MET320J, MET328J, MET328L, MET337J, MET340J, MET342J, MET344J, MET56L, PHE275L, PHE316J, PHE327L, PHE349J, PHE411J, PHE83L, PRO107L, PRO267L, PRO292J, PRO331L, PRO88L, SER280J, SER2J, SER302J, SER302L, SER317J, SER348J, SER371L, SER87L, SER90L, THR109L, THR338J, THR347J, THR392J, THR59L, THR98L, TRP325L, TRP326L, TRP389J, TRP58L, TRP79L, TYR115L, TYR364L, TYR381J, TYR48L, TYR50L, VAL261L, VAL265L, VAL276L, VAL284J, VAL310J, VAL311J, VAL376J, VAL391J, VAL400J, VAL52L, VAL55L, VAL89L, VAL96L
• K-L: ALA108K, ALA268K, ALA272K, ALA279K, ALA313L, ALA387L, ALA53K, ALA92K, ARG110K, ARG264K, ARG289L, ARG303K, ARG303L, ARG314L, ARG339L, ARG341L, ARG398L, ARG406L, ARG410L, ARG57K, ARG86K, ARG94K, ASN305K, ASN305L, ASN318L, ASN329K, ASN330K, ASN335K, ASN335L, ASN407L, ASP106K, ASP111K, ASP271K, ASP274K, ASP282L, ASP379L, ASP382L, ASP383L, ASP399L, ASP402L, ASP60K, CYS93K, CYS99K, GLN101K, GLN306L, GLN386L, GLU285L, GLU290L, GLU304K, GLU304L, GLU308L, GLU332K, GLU332L, GLU336K, GLU336L, GLU343L, GLU390L, GLU395L, GLU54K, GLU80K, GLU81K, GLU91K, GLY102K, GLY270K, GLY273K, GLY277K, GLY346L, GLY388L, GLY95K, HIS266K, HIS286L, HIS307L, HIS367K, HIS368K, HIS49K, ILE321L, ILE333K, ILE333L, ILE334K, ILE350L, ILE372K, ILE384L, ILE396L, ILE84K, LEU100K, LEU105K, LEU112K, LEU269K, LEU288L, LEU301K, LEU309L, LEU312L, LEU319L, LEU345L, LEU377L, LEU385L, LEU403L, LEU46K, LEU51K, LEU82K, LEU97K, LEU9L, LYS262K, LYS263K, LYS278K, LYS278L, LYS315L, LYS380L, LYS397L, LYS85K, MET281L, MET320L, MET328K, MET337L, MET340L, MET342L, MET344L, MET56K, PHE275K, PHE296L, PHE316L, PHE327K, PHE349L, PHE411L, PHE83K, PRO107K, PRO267K, PRO292L, PRO331K, PRO88K, SER280L, SER302K, SER302L, SER317L, SER348L, SER87K, SER90K, THR109K, THR338L, THR347L, THR392L, THR59K, THR98K, TRP325K, TRP326K, TRP389L, TRP58K, TRP79K, TYR115K, TYR364K, TYR381L, TYR48K, TYR50K, VAL261K, VAL265K, VAL276K, VAL284L, VAL310L, VAL311L, VAL376L, VAL391L, VAL400L, VAL52K, VAL55K, VAL89K, VAL96K