3HHR

human growth hormone and extracellular domain of its receptor: crystal structure of the complex

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 118
  • Norm. En. per Res.: -3.4772
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-36.5526	-60.7243	-313.028	-410.3049	118	18	0	12960	8	43	48
A-C	-16.5923	0.2951	-225.121	-241.4183	76	9	0	8469	5	20	23
B-C	-26.6699	-10.8974	-142.154	-179.7213	60	3	1	5317	1	4	7

Interface residues

• A-B: ALA163B, ALA17A, ALA24A, ARG167A, ARG178A, ARG183A, ARG19A, ARG217B, ARG43B, ARG64A, ARG70B, ARG71B, ASN162B, ASN218B, ASN221B, ASN47A, ASN63A, ASN72B, ASP119B, ASP126B, ASP164B, ASP169A, ASP171A, ASP26A, CYS108B, CYS122B, CYS182A, CYS189A, CYS38B, CYS53A, GLN166B, GLN181A, GLN216B, GLN22A, GLN29A, GLN46A, GLN68A, GLN78B, GLU120B, GLU127B, GLU173B, GLU174A, GLU186A, GLU32A, GLU42B, GLU44B, GLU56A, GLU65A, GLU66A, GLY168B, GLY187A, GLY190A, GLY220B, HIS18A, HIS21A, ILE103B, ILE105B, ILE109B, ILE165B, ILE179A, LEU15A, LEU172B, LEU177A, LEU193B, LEU20A, LEU23A, LEU45A, LEU52A, LEU75A, LYS121B, LYS167B, LYS168A, LYS172A, LYS215B, LYS38A, LYS41A, MET14A, MET170A, MET170B, PHE100B, PHE123B, PHE176A, PHE25A, PHE35B, PHE44A, PRO106B, PRO48A, PRO61A, SER102B, SER124B, SER188A, SER219B, SER43A, SER51A, SER62A, SER98B, SER99B, THR101B, THR175A, THR50A, THR60A, THR67A, THR69B, THR77B, TRP104B, TRP169B, TRP76B, TRP80B, TYR107B, TYR160A, TYR164A, TYR28A, TYR42A, VAL125B, VAL129B, VAL171B, VAL173A, VAL180A
• A-C: ALA13A, ALA163C, ALA17A, ARG127A, ARG16A, ARG19A, ARG217C, ARG43C, ARG70C, ARG71C, ARG8A, ASN109A, ASN12A, ASN218C, ASN72C, ASP112A, ASP116A, ASP11A, ASP126C, ASP164C, CYS108C, CYS122C, GLN122A, GLN166C, GLN216C, GLN22A, GLN78C, GLU118A, GLU119A, GLU120C, GLU127C, GLU42C, GLU44C, GLY104A, GLY120A, GLY168C, GLY220C, HIS18A, ILE103C, ILE105C, ILE121A, ILE165C, ILE4A, LEU113A, LEU117A, LEU124A, LEU15A, LEU20A, LEU6A, LEU9A, LYS115A, LYS121C, LYS167C, MET14A, MET170C, PHE10A, PHE123C, PHE1A, PRO106C, PRO2A, PRO5A, SER102C, SER124C, SER219C, SER7A, SER98C, THR101C, THR123A, THR3A, TRP104C, TRP169C, TYR103A, TYR107C, VAL125C, VAL129C, VAL171C
• B-C: ALA151B, ALA151C, ARG217B, ASN143B, ASN143C, ASP152B, ASP152C, ASP190B, ASP190C, GLN154B, GLN154C, GLY148B, GLY148C, GLY168C, HIS150B, HIS150C, ILE149B, ILE149C, ILE153B, ILE153C, ILE192B, ILE192C, LEU141C, LEU142B, LEU142C, LEU146B, LEU146C, LEU193B, LEU193C, LEU202B, LEU202C, LYS203B, LYS203C, MET189B, MET189C, PRO191C, PRO198B, PRO198C, SER145B, SER145C, SER196C, SER201B, SER201C, THR147B, THR147C, THR194B, THR194C, THR195C, TRP157C, TYR178B, TYR200B, TYR200C, VAL144B, VAL144C, VAL171C, VAL197B, VAL197C, VAL199B, VAL199C, VAL204C