3HHM

crystal structure of p110alpha h1047r mutant in complex with nish2 of p85alpha and the drug wortmannin

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 275
  • Norm. En. per Res.: -3.0645
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-92.8553	-144.7624	-605.131	-842.7486	275	29	9	25632	9	111	111

Interface residues

• A-B: ALA1020A, ALA351B, ALA360B, ALA414B, ALA423A, ALA483B, ALA486B, ALA511A, ALA553B, ALA554B, ALA77A, ARG1023A, ARG340B, ARG348B, ARG349A, ARG357A, ARG358B, ARG373B, ARG412A, ARG465B, ARG481B, ARG503B, ARG523B, ARG534B, ARG537A, ARG542B, ARG557B, ARG562B, ARG574B, ARG79A, ASN28A, ASN344B, ASN345A, ASN347A, ASN377B, ASN378B, ASN417B, ASN465A, ASN467A, ASN488B, ASN527B, ASN564B, ASN575A, ASP1017A, ASP1018A, ASP1029A, ASP349B, ASP350A, ASP352A, ASP352B, ASP369A, ASP390A, ASP394B, ASP395A, ASP454A, ASP464B, ASP549A, ASP560B, ASP569B, ASP843A, CYS24A, CYS368A, CYS407A, CYS498B, GLN415B, GLN432B, GLN475B, GLN478B, GLN497B, GLN499B, GLN501B, GLN522B, GLN546A, GLN572B, GLN60A, GLN721A, GLN75A, GLN96A, GLU1034A, GLU127A, GLU23A, GLU341B, GLU342B, GLU345B, GLU365A, GLU453A, GLU468B, GLU469A, GLU476B, GLU485B, GLU489B, GLU495B, GLU496B, GLU502B, GLU507B, GLU520B, GLU537B, GLU542A, GLU545A, GLU547A, GLU558B, GLU579A, GLU76A, GLU78A, GLU80A, GLY12A, GLY29A, GLY364A, GLY366B, GLY375B, GLY376B, GLY391B, GLY411A, GLY451A, GLY512A, HIS450A, HIS510A, HIS526B, HIS59A, HIS676A, ILE102A, ILE31A, ILE348A, ILE360A, ILE381B, ILE383B, ILE406A, ILE477B, ILE484B, ILE491B, ILE493B, ILE509B, ILE521B, ILE524B, ILE535B, ILE538B, ILE543A, ILE559B, ILE566B, ILE571B, LEU1028A, LEU25A, LEU26A, LEU367A, LEU370B, LEU372B, LEU380B, LEU404B, LEU420B, LEU422A, LEU452A, LEU455A, LEU456A, LEU513A, LEU531A, LEU531B, LEU540A, LEU545B, LEU549B, LEU570A, LEU570B, LEU58A, LEU61A, LEU62A, LEU94A, LEU99A, LYS100A, LYS1024A, LYS1030A, LYS363B, LYS374B, LYS379B, LYS382B, LYS410A, LYS419B, LYS459B, LYS468A, LYS480B, LYS492B, LYS506B, LYS511B, LYS519B, LYS528A, LYS530B, LYS532B, LYS548A, LYS55A, LYS561B, LYS567B, LYS573A, LYS575B, LYS678A, MET30A, MET479B, MET525B, MET563B, PHE1016A, PHE384B, PHE392B, PHE456B, PHE487B, PHE494B, PHE512B, PHE550A, PHE95A, PHE98A, PRO27A, PRO366A, PRO418B, PRO421A, PRO447A, PRO449A, PRO466A, PRO471A, PRO539A, PRO568B, PRO57A, PRO5A, PRO97A, SER1015A, SER339B, SER361B, SER393B, SER408A, SER460B, SER474B, SER505B, SER509A, SER514A, SER541A, SER541B, SER565B, SER576A, SER6A, SER72A, SER7A, THR1031A, THR33A, THR350B, THR362B, THR369B, THR371B, THR470A, THR471B, THR482B, THR490B, THR500B, THR544A, THR74A, TRP11A, TRP424A, TRP446A, TYR343A, TYR355A, TYR361A, TYR368B, TYR416B, TYR463B, TYR467B, TYR470B, TYR504B, TYR508B, TYR528B, TYR556B, TYR56A, TYR68A, VAL101A, VAL32A, VAL344A, VAL346A, VAL371A, VAL409A, VAL448A, VAL71A, VAL73A