3HH2

crystal structure of the myostatin:follistatin 288 complex

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 167
  • Norm. En. per Res.: -3.5141
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-49.2	-2.3086	311.019	259.5104	127	13	16	13153	0	15	18
A-C	-12.7616	0.0	-107.214	-119.9757	46	1	2	3982	0	4	3
A-D	-84.1184	-76.5314	-383.132	-543.7818	165	15	12	15874	5	59	33
B-C	-91.1449	-111.4346	-384.279	-586.8585	167	21	13	16374	6	59	36
B-D	-11.7968	-3.186	-103.279	-118.2618	46	1	2	3898	0	4	3
C-D	-42.7343	-78.2119	-133.16	-254.1063	80	8	0	5463	5	21	14

Interface residues

• A-B: ALA100A, ALA100B, ALA26A, ALA26B, ALA40A, ALA40B, ALA64A, ALA64B, ALA70A, ALA70B, ARG17A, ARG17B, ARG67A, ARG67B, ASN41A, ASN41B, ASN65A, ASN65B, ASP104A, ASP104B, ASP23A, ASP23B, CYS106A, CYS106B, CYS108A, CYS108B, CYS43A, CYS43B, CYS73A, CYS73B, CYS74A, CYS74B, GLN63A, GLN63B, GLU8A, GLU8B, GLY107B, GLY28A, GLY28B, GLY45A, GLY45B, GLY68A, GLY68B, GLY71A, GLY71B, HIS57A, HIS57B, HIS59A, HIS59B, HIS62A, HIS62B, ILE32B, ILE82A, ILE82B, ILE98A, ILE98B, LEU20A, LEU20B, LEU60A, LEU60B, LYS39A, LYS39B, LYS54A, LYS54B, LYS78B, MET101A, MET101B, MET79A, MET79B, MET84A, MET84B, PHE24A, PHE24B, PHE27A, PHE27B, PRO19A, PRO19B, PRO56A, PRO56B, PRO66A, PRO66B, PRO72A, PRO72B, PRO76A, PRO76B, PRO81A, PRO81B, PRO99A, PRO99B, SER109A, SER109B, SER44A, SER44B, SER69A, SER69B, SER80A, SER80B, THR21A, THR21B, THR58A, THR58B, THR75A, THR75B, THR77A, THR77B, TRP29A, TRP29B, TRP31A, TRP31B, TYR18A, TYR18B, TYR38A, TYR38B, TYR42A, TYR42B, TYR55A, TYR55B, VAL102A, VAL102B, VAL103A, VAL103B, VAL22A, VAL22B, VAL50A, VAL50B, VAL61A, VAL61B
• A-C: ALA100A, ALA26A, ALA34A, ARG12C, ASN42C, ASN44C, ASN53C, ASN83A, ASN88A, ASP30A, ASP43C, GLN92A, GLU25A, GLU91A, GLY28A, GLY54C, GLY89A, GLY96A, ILE32A, ILE33A, ILE51C, ILE82A, ILE94A, ILE98A, LEU46C, LEU85A, LYS48C, LYS90A, LYS97A, MET101A, MET50C, MET84A, PHE24A, PHE27A, PHE47C, PHE52C, PHE87A, PRO35A, PRO57C, PRO99A, THR45C, TRP29A, TRP31A, TRP49C, TYR38A, TYR86A
• A-D: ALA158D, ALA188D, ALA194D, ALA205D, ALA34A, ALA40A, ALA8D, ARG105A, ARG120D, ARG14A, ARG17A, ARG192D, ARG200D, ARG237D, ARG31D, ARG37A, ARG6D, ARG86D, ASN156D, ASN157D, ASN164D, ASN180D, ASN2D, ASN41A, ASN42D, ASN44D, ASN83A, ASN88A, ASP104A, ASP106D, ASP153D, ASP1A, ASP1A5, ASP30A, ASP43D, ASP5A, CB4.30183-77.96571, CB8.31167-37.94821, CYS106A, CYS108A, CYS150D, CYS15A, CYS160D, CYS163D, CYS16A, CYS189D, CYS196D, CYS238D, CYS241D, CYS3D, CYS6A, GLN124D, GLN130D, GLN14D, GLN154D, GLN53A, GLN63A, GLN7D, GLN92A, GLU123D, GLU126D, GLU128D, GLU12A, GLU20D, GLU243D, GLU25A, GLU280D, GLU48A, GLU91A, GLY104D, GLY107A, GLY107D, GLY179D, GLY199D, GLY203D, GLY28A, GLY3A, GLY89A, GLY96A, HIS57A, HIS59A, ILE202D, ILE32A, ILE33A, ILE51D, ILE82A, ILE93A, ILE94A, LEU105D, LEU127D, LEU16D, LEU177D, LEU191D, LEU197D, LEU198D, LEU204D, LEU21D, LEU228D, LEU240D, LEU278D, LEU32D, LEU46D, LEU4A, LEU52A, LEU5D, LEU60A, LEU85A, LYS108D, LYS18D, LYS193D, LYS225D, LYS269D, LYS36A, LYS39A, LYS54A, LYS75D, LYS90A, LYS97A, LYS9D, MET101A, MET50D, MET84A, PHE24A, PHE2A, PHE47D, PHE49A, PHE51A, PHE52D, PHE87A, PRO125D, PRO168D, PRO35A, PRO56A, PRO81A, SER13A, SER187D, SER201D, SER239D, SER33D, SER80A, THR155D, THR162D, THR195D, THR19D, THR21A, THR29D, THR34D, TRP29A, TRP31A, TRP4D, TYR159D, TYR17D, TYR38A, TYR55A, TYR86A, TYR95A, VAL102A, VAL103A, VAL151D, VAL152D, VAL15D, VAL161D, VAL22A, VAL41D, VAL50A
• B-C: ALA158C, ALA188C, ALA194C, ALA205C, ALA34B, ALA40B, ALA8C, ARG105B, ARG120C, ARG14B, ARG165C, ARG17B, ARG192C, ARG200C, ARG237C, ARG31C, ARG37B, ARG6C, ARG86C, ASN156C, ASN157C, ASN164C, ASN180C, ASN2C, ASN41B, ASN42C, ASN44C, ASN83B, ASN88B, ASP104B, ASP106C, ASP153C, ASP1B, ASP30B, ASP43C, ASP5B, CYS106B, CYS108B, CYS150C, CYS15B, CYS160C, CYS163C, CYS16B, CYS189C, CYS196C, CYS238C, CYS241C, CYS3C, CYS87C, GLN124C, GLN130C, GLN14C, GLN154C, GLN175C, GLN53B, GLN63B, GLN7C, GLN92B, GLU123C, GLU126C, GLU128C, GLU12B, GLU207C, GLU20C, GLU25B, GLU280C, GLU48B, GLU91B, GLY104C, GLY107B, GLY107C, GLY179C, GLY199C, GLY203C, GLY28B, GLY3B, GLY89B, GLY96B, HIS57B, HIS59B, HIS62B, ILE202C, ILE32B, ILE33B, ILE51C, ILE82B, ILE93B, ILE94B, LEU105C, LEU127C, LEU16C, LEU177C, LEU191C, LEU197C, LEU198C, LEU204C, LEU21C, LEU228C, LEU240C, LEU278C, LEU32C, LEU46C, LEU4B, LEU52B, LEU5C, LEU60B, LEU85B, LYS108C, LYS18C, LYS193C, LYS225C, LYS269C, LYS36B, LYS39B, LYS54B, LYS78B, LYS90B, LYS97B, LYS9C, MET101B, MET50C, MET84B, PHE24B, PHE2B, PHE47C, PHE49B, PHE51B, PHE52C, PHE87B, PRO125C, PRO168C, PRO35B, PRO56B, PRO81B, SER13B, SER187C, SER201C, SER239C, SER33C, SER80B, THR11B, THR155C, THR162C, THR195C, THR19C, THR21B, THR29C, THR34C, THR58B, TRP29B, TRP31B, TRP4C, TYR110C, TYR159C, TYR17C, TYR38B, TYR55B, TYR86B, TYR95B, VAL102B, VAL103B, VAL151C, VAL152C, VAL15C, VAL161C, VAL41C, VAL50B
• B-D: ALA100B, ALA26B, ALA34B, ARG12D, ASN42D, ASN44D, ASN53D, ASN83B, ASN88B, ASP30B, ASP43D, GLN92B, GLU25B, GLU91B, GLY28B, GLY54D, GLY89B, GLY96B, ILE32B, ILE33B, ILE51D, ILE82B, ILE94B, ILE98B, LEU46D, LEU85B, LYS48D, LYS90B, LYS97B, MET101B, MET50D, MET84B, PHE24B, PHE27B, PHE47D, PHE52D, PHE87B, PRO35B, PRO57D, PRO99B, THR45D, TRP29B, TRP31B, TRP49D, TYR38B, TYR86B
• C-D: ALA188C, ALA188D, ALA56C, ALA56D, ALA8C, ALA8D, ARG12C, ARG12D, ARG192C, ARG192D, ARG86C, ASN10C, ASN10D, ASN42D, ASN53C, ASN53D, ASN58C, ASN58D, ASP242C, ASP242D, CYS13C, CYS13D, CYS241C, CYS241D, CYS245C, CYS245D, CYS266D, CYS59C, CYS59D, GLN175C, GLN7C, GLN7D, GLU207C, GLU243C, GLU243D, GLU38C, GLU38D, GLU39C, GLU39D, GLY11C, GLY11D, GLY223C, GLY223D, GLY224C, GLY224D, GLY54C, GLY55C, GLY55D, ILE60C, ILE60D, LEU204C, LEU204D, LEU240C, LEU240D, LEU244C, LEU244D, LYS225C, LYS225D, LYS269C, LYS269D, LYS48C, LYS48D, LYS82C, LYS84C, LYS84D, LYS9C, LYS9D, PRO246C, PRO246D, PRO57C, PRO57D, PRO61C, PRO61D, SER239C, SER239D, THR222C, THR222D, THR45D, TRP49C, TRP49D