3HF9

crystal structure of mycobacterium tuberculosis proteasome open-gate mutant modified by inhibitor gl1

• Total interactions analyzed: 1540
• Total true interactions: 147
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 59
  • Norm. En. per Res.: -5.219
• Hub Node: F(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-10.1826	0.6132	-106.802	-116.3714	75	2	3	6143	0	23	25
A-O	-17.9977	15.4329	-98.8754	-101.4402	80	8	1	5803	0	23	24
A-H	-29.9895	-110.6778	-129.541	-270.2083	60	8	2	5360	13	38	33
A-P	-10.2759	-1.9397			13
B-I	-18.6493	30.6377	-132.082	-120.0936	84	10	2	6400	0	25	22
B-H	-9.2159	-0.4489	-84.5337	-94.1984	39	2	1	3212	1	16	18
B-C	-35.3124	-107.9649	-166.051	-309.3283	61	15	2	6156	15	40	35
D-K	-19.1625	14.7797	-148.159	-152.5418	83	20	2	7185	0	24	24
D-Q	-4.344	-27.8315	-84.5093	-116.6848	81	9	1	5381	1	24	21
D-E	-54.3014	-131.7941	-121.824	-307.9195	59	16	2	5502	15	39	36
D-R	-23.13	0.5649			12
F-M	-13.8515	-34.8335	-105.082	-153.767	72	6	2	5494	1	16	14
F-W	-2.2818	3.9476	-107.024	-105.3583	65	9	1	5366	0	13	15
F-G	-7.9734	-69.321			16
F-N	-4.3359	9.6397			10
F-r	-4.7913	13.275			12
I-S	-30.9392	4.3993	-128.769	-155.309	82	21	2	7092	1	26	25
I-C	-22.424	-20.4287	-83.3413	-126.194	41	3	1	3263	1	18	18
I-J	-30.3086	-63.0838			16
K-M	-31.1685	-18.4942	-166.17	-215.8327	80	16	2	7362	1	23	26
K-E	-19.8253	-7.7793	-87.3853	-114.9899	40	5	1	3291	2	17	20
K-L	-42.5052	-60.4915			18
K-j	-19.1336	-28.9846			10
M-L	-16.8039	-4.7599			13
M-N	-47.0482	-67.7446			16
M-j	-9.541	30.14			7
O-U	0.0	-10.3767	-87.2064	-97.5831	71	5	1	5255	1	23	21
O-P	-30.7459	-39.6404			18
O-V	-25.7014	-23.5902			12
Q-Y	-14.7006	-0.1718	-154.194	-169.0664	84	12	3	7157	0	26	27
Q-i	0.0	-0.1689	-49.9514	-50.1203	41	9	3	2311	0	10	10
Q-R	-29.9953	-61.4776			18
Q-Z	-21.6255	-6.342			14
Q-c	0.0	13.0721			2
S-1	-9.2067	-15.0433	-109.643	-133.8929	77	11	2	5688	1	25	22
S-J	-14.5203	-7.4291			13
S-T	-44.9511	-62.4943			16
U-1	-16.6265	-19.1197	-130.069	-165.8152	81	20	2	6938	1	24	25
U-V	-41.0874	-39.9646			17
U-2	-19.2437	-4.2794			13
W-Y	-29.2778	-25.4836	-136.253	-191.0144	71	16	2	6383	1	16	20
W-G	-21.2885	-7.0624			13
W-X	-13.3362	-58.4352			16
Y-b	0.0	0.0	-0.0016	-0.0016	2	0	0	1	0	0	0
Y-X	-19.2462	0.9829			11
Y-Z	-31.9104	-77.3739			15
Y-c	-12.1339	12.4129			6
1-T	-14.4023	-18.7207			11
1-2	-36.9979	-79.2236			17
a-b	-20.9909	-19.2021	-125.016	-165.209	85	13	3	6854	1	23	26
a-o	-2.5183	3.0804	-91.5437	-90.9816	75	6	1	5493	1	25	20
a-h	-31.9902	-59.7758			16
a-p	-20.3802	-22.8806			14
b-i	-5.5251	14.1038	-100.593	-92.0143	76	6	1	5600	0	24	22
b-h	-21.6713	-6.5414			15
b-c	-37.2366	-69.2431			19
d-k	-18.9584	23.1908	-125.155	-120.9226	81	22	2	6954	0	23	26
d-q	-11.7114	-22.9811	-101.551	-136.2435	79	15	1	5611	2	24	22
d-e	-18.4888	-74.2016			15
d-r	-19.1877	-20.1873			12
f-m	-7.4852	-1.9134	-100.002	-109.4005	76	2	1	5789	0	25	25
f-w	-19.5854	-39.3281	-80.9179	-139.8313	76	13	1	5546	2	24	23
f-g	-30.9993	-42.7028			17
f-n	-23.6751	-6.8169			12
i-s	-18.2708	-13.3843	-163.914	-195.5691	81	10	2	7380	0	26	25
i-c	-21.2907	-20.7361			11
i-j	-40.8357	-69.736			15
k-m	-5.724	-8.0505	-162.051	-175.8255	87	5	3	7377	0	26	28
k-e	-19.4325	-9.2743			13
k-l	-21.0113	-24.9449			15
m-l	-25.8293	-10.0093			13
m-n	-36.4711	-31.1962			17
o-u	-14.3216	-4.4726	-107.53	-126.3242	74	7	1	5726	1	24	22
o-p	-40.4641	-67.8961			17
o-v	-24.7851	-25.0157			13
q-y	-30.3233	-1.031	-130.027	-161.3813	77	6	2	6168	0	26	25
q-r	-38.0238	-63.0966			22
q-z	-14.3312	-4.3458			13
s-3	-11.192	6.9311	-125.583	-129.844	82	11	2	6471	0	25	25
s-j	-19.9494	-13.4543			14
s-t	-46.1451	-58.2725			17
u-3	-16.7924	0.9916	-124.785	-140.5858	79	7	2	6485	0	27	25
u-v	-31.0663	-39.7083			16
u-4	-19.2128	-24.4922			13
w-y	-24.9895	-2.4219	-47.6009	-75.0123	87	33	2	7086	2	25	25
w-g	-13.5944	-4.8709			12
w-x	-24.9505	-60.7768			16
y-x	-18.2089	-16.9374			11
y-z	-15.0068	-46.8812			13
3-t	-17.152	-22.8834			13
3-4	-27.4519	-63.0646			15
H-C	-25.2958	-39.327	-64.2054	-128.8282	51	5	0	3015	4	23	13
H-E	-35.2863	-111.1458	-90.9448	-237.3769	52	10	1	4254	12	27	25
H-L	-71.8799	-105.7568			18
H-P	-10.1775	-28.2296			8
C-E	-79.1575	-42.5156	-144.62	-266.2931	67	10	1	5553	7	24	14
C-J	-22.1651	-29.6823			8
C-R	-33.523	-100.046			13
E-L	-22.3362	-35.1464			10
E-R	-9.4518	-29.5842			8
G-N	-17.4826	-31.402			8
G-V	-77.0549	-107.2845			18
G-X	-14.9422	-31.9006			10
G-2	-32.544	-106.2089			12
J-R	-69.1768	-24.33			16
J-T	-26.6401	-35.9155			10
J-Z	-34.2363	-105.9196			13
L-N	-17.1898	-29.7428			8
L-P	-30.5349	-102.6096			12
N-P	-72.9103	-135.1614			18
N-V	-37.9585	-106.6528			12
P-V	-22.9713	-32.3454			10
R-Z	-19.2415	-32.4087			8
T-X	-33.6947	-105.1851			12
T-Z	-61.304	-41.9262			16
T-2	-23.3564	-32.382			10
V-2	-29.3166	-39.4759			10
X-Z	-17.9966	-30.3949			8
X-2	-81.1185	-105.6544			18
h-c	-21.1739	-31.7929			8
h-e	-33.9749	-109.1853			12
h-l	-77.2109	-136.6831			18
h-p	-8.291	-29.028			8
c-e	-86.4145	-112.4807			18
c-j	-26.0369	-29.8146			10
c-r	-32.8194	-107.0017			17
e-l	-15.4553	-29.9209			8
e-r	-9.0302	-29.2692			9
g-n	-16.4556	-30.6618			8
g-v	-81.5095	-112.2273			18
g-x	-23.7377	-33.5439			10
g-4	-34.7316	-108.8806			12
j-r	-81.9226	-84.7149			25
j-t	-30.4943	-43.8342			10
j-z	-36.026	-110.8681			12
l-n	-17.0838	-30.3608			8
l-p	-34.4713	-102.9509			12
n-p	-74.117	-111.4667			18
n-v	-32.5012	-105.4465			12
p-v	-21.8303	-30.5344			10
r-z	-22.4292	-31.4443			11
t-x	-34.1564	-104.3043			12
t-z	-73.4619	-70.956			18
t-4	-24.3742	-31.4182			10
v-4	-27.276	-37.5728			10
x-z	-19.7753	-34.6482			8
x-4	-74.242	-69.074			18

Interface residues

• A-B: ALA100B, ALA104B, ALA115A, ALA12A, ALA12B, ALA148B, ALA20A, ARG135B, ARG140B, ARG14B, ARG16A, ARG16B, ARG224A, ARG26A, ARG48A, ARG75A, ARG76A, ARG85B, ARG97B, ASN101B, ASN69A, ASN73A, ASP144B, ASP149B, ASP72A, GLN105B, GLN114A, GLN114B, GLN11B, GLN51A, GLN98B, GLU10B, GLU113B, GLU119A, GLU137B, GLU150B, GLU15A, GLU18A, GLU70A, GLY108B, GLY145B, HIS152B, ILE110A, ILE141B, ILE147B, LEU107B, LEU138B, LEU19A, LEU50A, LEU74A, LYS116A, LYS134B, LYS22A, LYS67A, MET13B, PHE111B, PHE68A, PHE71A, PHE81B, PRO117A, PRO136B, PRO151B, PRO46A, SER146B, SER47A, SER49A, THR106B, THR109B, THR112B, THR142B, TYR103B, TYR118A, TYR139B, TYR143B, VAL102B
• A-O: 0112CB7.1304, 9112CB8.1984, ALA100A, ALA104A, ALA115O, ALA12A, ALA12O, ALA148A, ARG135A, ARG140A, ARG14A, ARG16A, ARG16O, ARG26O, ARG48O, ARG75O, ARG76O, ARG85A, ARG97A, ASN101A, ASN45O, ASN69O, ASN73O, ASP144A, ASP149A, ASP72O, GLN105A, GLN114A, GLN114O, GLN11A, GLN51O, GLN98A, GLU10A, GLU10A5, GLU113A, GLU119O, GLU126A, GLU137A, GLU150A, GLU15O, GLU18O, GLU70O, GLY108A, GLY145A, GLY96A, HIS152A, ILE110O, ILE141A, ILE147A, LEU107A, LEU138A, LEU19O, LEU50O, LEU74O, LYS116O, LYS134A, LYS22O, LYS67O, MET13A, PHE111A, PHE68O, PHE71O, PHE81A, PRO117O, PRO136A, PRO151A, PRO46O, SER146A, SER47O, SER49O, THR106A, THR109A, THR112A, THR142A, THR95A, TYR103A, TYR118O, TYR139A, TYR143A, VAL102A
• A-H: ALA56H, ALA60H, ALA82A, ALA88A, ARG217A, ARG219A, ARG220A, ARG224A, ARG57H, ARG59A, ARG75A, ARG76A, ARG85A, ARG91A, ASN73A, ASN90H, ASP38H, ASP39H, ASP58A, ASP72A, ASP83A, ASP90A, GLN51A, GLN80A, GLU54H, GLU55A, GLU62H, GLU64H, GLU67H, GLU70H, GLY71H, GLY77A, GLY78A, GLY86A, HIS65H, ILE79A, LEU56A, LEU58H, LEU63H, LEU69H, LEU99A, LYS68H, MET86H, PHE222A, PHE55H, PHE81A, PRO73H, SER54A, THR37H, THR84A, TYR57A, TYR59H, TYR66H, TYR87A, TYR89A, VAL53H, VAL60A, VAL61H, VAL72H, VAL94A
• A-P: ALA88A, ARG82P, ARG92A, ARG97A, ASN81P, ASP90A, ASP93A, GLU132A, GLU70P, HIS110P, LYS79P, TYR87A, TYR89A
• B-I: ALA100I, ALA104I, ALA115B, ALA12B, ALA12I, ALA148I, ALA34I, ARG135I, ARG140I, ARG14I, ARG16B, ARG16I, ARG224B, ARG48B, ARG75B, ARG76B, ARG85I, ARG97I, ASN101I, ASN45B, ASN69B, ASN73B, ASP144I, ASP149I, ASP72B, ASP93I, GLN105I, GLN114B, GLN114I, GLN11I, GLN51B, GLN80B, GLN98I, GLU10I, GLU113B, GLU113I, GLU119B, GLU126I, GLU137I, GLU150I, GLU15B, GLU18B, GLU70B, GLY108I, GLY145I, GLY77B, GLY96I, HIS152I, ILE110B, ILE141I, ILE147I, LEU107I, LEU138I, LEU19B, LEU50B, LEU74B, LYS116B, LYS134I, LYS22B, LYS67B, MET13I, PHE111I, PHE68B, PHE71B, PHE81I, PRO117B, PRO136I, PRO151I, PRO46B, SER146I, SER47B, SER49B, SER54B, THR106I, THR109I, THR112I, THR142I, THR95I, TYR103I, TYR118B, TYR139I, TYR143I, TYR89I, VAL102I
• B-H: ALA77H, ALA88B, ARG82H, ARG85B, ARG88H, ARG91B, ARG92B, ARG97B, ASN101B, ASN81H, ASP90B, ASP93B, GLN98B, GLU132B, GLU62H, GLU70H, GLY71H, GLY78H, GLY86B, HIS110H, HIS65H, ILE80H, ILE85H, LEU63H, LEU69H, LEU74H, LYS68H, LYS79H, PHE76H, PHE81B, PRO73H, THR75H, THR84B, THR95B, TYR66H, TYR87B, TYR89B, VAL72H, VAL94B
• B-C: ALA56C, ALA60C, ALA82B, ALA88B, ARG217B, ARG219B, ARG220B, ARG224B, ARG57C, ARG75B, ARG76B, ARG85B, ARG91B, ASN73B, ASN90C, ASP38C, ASP39C, ASP58B, ASP72B, ASP83B, ASP90B, GLN51B, GLN80B, GLU54C, GLU55B, GLU62C, GLU64C, GLU67C, GLU70C, GLY61B, GLY71C, GLY77B, GLY78B, GLY86B, HIS65C, ILE36C, ILE79B, LEU56B, LEU58C, LEU63C, LEU69C, LEU99B, LYS68C, MET86C, PHE222B, PHE55C, PHE81B, PRO73C, SER54B, THR37C, THR84B, TYR57B, TYR59C, TYR66C, TYR87B, TYR89B, VAL53C, VAL60B, VAL61C, VAL72C, VAL94B
• D-K: ALA100K, ALA104K, ALA115D, ALA12D, ALA12K, ALA148K, ALA34K, ARG135K, ARG140K, ARG14K, ARG16D, ARG16K, ARG48D, ARG75D, ARG76D, ARG85K, ARG97K, ASN101K, ASN45D, ASN69D, ASN73D, ASP144K, ASP149K, ASP72D, GLN105K, GLN114D, GLN11D, GLN11K, GLN51D, GLN80D, GLN98K, GLU10K, GLU113D, GLU113K, GLU119D, GLU126K, GLU137K, GLU150K, GLU15D, GLU70D, GLY108K, GLY145K, GLY77D, GLY96K, HIS152K, ILE110D, ILE141K, ILE147K, LEU107K, LEU138K, LEU19D, LEU50D, LEU74D, LEU99K, LYS116D, LYS134K, LYS22D, LYS67D, MET13D, MET13K, PHE111K, PHE68D, PHE71D, PHE81K, PRO117D, PRO136K, PRO151K, PRO46D, SER146K, SER47D, SER49D, SER54D, THR106K, THR109K, THR112K, THR142K, THR95K, TYR103K, TYR118D, TYR139K, TYR143K, TYR89K, VAL102K
• D-Q: ALA100D, ALA104D, ALA115Q, ALA12D, ALA12Q, ALA148D, ALA20Q, ARG135D, ARG14D, ARG14Q, ARG16D, ARG16Q, ARG21Q, ARG26Q, ARG48Q, ARG75Q, ARG76Q, ARG85D, ARG97D, ASN101D, ASN69Q, ASN73Q, ASP144D, ASP149D, ASP72Q, GLN105D, GLN114D, GLN114Q, GLN11D, GLN11Q, GLN51Q, GLN80Q, GLN98D, GLU10D, GLU113D, GLU113Q, GLU119Q, GLU126D, GLU137D, GLU150D, GLU15Q, GLU18Q, GLU70Q, GLY108D, GLY145D, GLY23Q, ILE110Q, ILE141D, ILE147D, LEU107D, LEU138D, LEU19Q, LEU50Q, LEU74Q, LYS116Q, LYS134D, LYS22Q, LYS67Q, MET13D, PHE111D, PHE68Q, PHE71Q, PHE81D, PRO117Q, PRO136D, PRO151D, PRO46Q, SER146D, SER17Q, SER47Q, SER49Q, THR106D, THR109D, THR112D, THR95D, TYR103D, TYR118Q, TYR139D, TYR143D, TYR89D, VAL102D
• D-E: ALA56E, ALA60E, ALA82D, ALA88D, ARG217D, ARG219D, ARG220D, ARG224D, ARG57E, ARG75D, ARG76D, ARG85D, ARG91D, ASN73D, ASN90E, ASP38E, ASP39E, ASP58D, ASP72D, ASP83D, ASP90D, GLN51D, GLN80D, GLU54E, GLU55D, GLU62E, GLU64E, GLU67E, GLU70E, GLY71E, GLY77D, GLY78D, GLY86D, HIS65E, ILE79D, LEU56D, LEU58E, LEU63E, LEU69E, LEU99D, LYS68E, MET86E, PHE222D, PHE55E, PHE81D, PRO73E, SER54D, THR37E, THR84D, TYR57D, TYR59E, TYR66E, TYR87D, TYR89D, VAL53E, VAL60D, VAL61E, VAL72E, VAL94D
• D-R: ALA88D, ARG82R, ARG92D, ARG97D, ASN81R, ASP90D, ASP93D, GLU70R, HIS110R, LYS79R, THR75R, TYR87D
• F-M: ALA100F, ALA104F, ALA115M, ALA148F, ARG135F, ARG140F, ARG16M, ARG224M, ARG26M, ARG48M, ARG75M, ARG76M, ARG85F, ARG97F, ASN101F, ASN69M, ASN73M, ASP144F, ASP149F, ASP72M, GLN105F, GLN114F, GLN114M, GLN51M, GLN80M, GLN98F, GLU113F, GLU113M, GLU119M, GLU126F, GLU137F, GLU150F, GLU209M, GLU70M, GLY108F, GLY145F, GLY96F, ILE110F, ILE110M, ILE141F, ILE147F, LEU107F, LEU138F, LEU19M, LEU50M, LEU74M, LYS116M, LYS134F, LYS52M, LYS67M, PHE111F, PHE68M, PHE71M, PHE81F, PRO117M, PRO136F, PRO151F, PRO46M, SER146F, SER47M, SER49M, SER54M, THR106F, THR109F, THR112F, THR95F, TYR103F, TYR118M, TYR139F, TYR143F, TYR89F, VAL102F
• F-W: ALA100W, ALA104W, ALA115F, ALA148W, ALA34W, ARG135W, ARG140W, ARG48F, ARG75F, ARG76F, ARG85W, ARG97W, ASN101W, ASN45F, ASN69F, ASN73F, ASP144W, ASP149W, ASP72F, GLN105W, GLN114F, GLN51F, GLN98W, GLU113F, GLU113W, GLU119F, GLU126W, GLU137W, GLU150W, GLU70F, GLY108W, GLY145W, GLY77F, GLY96W, HIS152W, ILE110F, ILE141W, ILE147W, LEU107W, LEU138W, LEU50F, LEU74F, LYS116F, LYS134W, LYS67F, PHE111W, PHE68F, PHE71F, PHE81W, PRO136W, PRO151W, PRO46F, SER146W, SER47F, SER49F, THR106W, THR109W, THR112W, THR142W, THR95W, TYR103W, TYR118F, TYR139W, TYR143W, VAL102W
• F-G: ARG220F, ARG57G, ARG75F, ARG76F, ARG91F, ASP39G, ASP58F, ASP83F, GLU55F, GLU62G, GLU64G, GLU67G, GLU70G, HIS65G, LEU69G, LYS68G
• F-N: ARG82N, ARG92F, ARG97F, ASN81N, ASP90F, ASP93F, GLU70N, HIS110N, LYS79N, TYR87F
• F-r: ARG509r, ASN165F, ASP144F, ASP459r, ASP461r, ASP498r, ASP500-4.7912712.427655, ASP500r, GLU161F, GLU169F, GLU512r, LYS168F
• I-S: ALA100S, ALA104S, ALA115I, ALA128S, ALA12I, ALA12S, ALA148S, ARG135S, ARG140S, ARG14S, ARG16I, ARG16S, ARG26I, ARG48I, ARG75I, ARG76I, ARG85S, ARG97S, ASN101S, ASN45I, ASN69I, ASN73I, ASP144S, ASP149S, ASP72I, GLN105S, GLN114I, GLN114S, GLN11S, GLN51I, GLN98S, GLU10S, GLU113I, GLU113S, GLU119I, GLU126S, GLU137S, GLU150S, GLU15I, GLU18I, GLU70I, GLY108S, GLY145S, GLY77I, GLY96S, ILE110I, ILE141S, ILE147S, LEU107S, LEU138S, LEU19I, LEU50I, LEU74I, LEU99S, LYS116I, LYS134S, LYS22I, LYS67I, MET13S, PHE111S, PHE68I, PHE71I, PHE81S, PRO117I, PRO136S, PRO151S, PRO46I, SER146S, SER47I, SER49I, THR106S, THR109S, THR112S, THR133S, THR142S, THR95S, TYR103S, TYR118I, TYR139S, TYR143S, VAL102S, VAL127S
• I-C: ALA77C, ALA88I, ARG82C, ARG85I, ARG88C, ARG91I, ARG92I, ARG97I, ASN101I, ASN81C, ASP90I, ASP93I, GLN98I, GLU132I, GLU62C, GLU67C, GLU70C, GLY71C, GLY78C, GLY86I, HIS110C, HIS129I, HIS65C, ILE80C, ILE85C, LEU63C, LEU69C, LEU74C, LYS68C, LYS79C, PHE76C, PHE81I, PRO73C, THR75C, THR84I, THR95I, TYR66C, TYR87I, TYR89I, VAL72C, VAL94I
• I-J: ARG219I, ARG220I, ARG57J, ARG75I, ARG76I, ARG91I, ASP58I, ASP83I, GLU55I, GLU62J, GLU64J, GLU67J, GLU70J, HIS65J, LEU69J, LYS68J
• K-M: ALA100M, ALA104M, ALA115K, ALA148M, ALA34M, ARG135M, ARG140M, ARG14M, ARG16K, ARG16M, ARG224K, ARG26K, ARG48K, ARG75K, ARG76K, ARG85M, ARG97M, ASN101M, ASN45K, ASN69K, ASN73K, ASP144M, ASP149M, ASP72K, GLN105M, GLN114K, GLN114M, GLN51K, GLN98M, GLU113K, GLU113M, GLU119K, GLU126M, GLU137M, GLU150M, GLU15K, GLU70K, GLY108M, GLY145M, GLY66K, GLY77K, GLY96M, HIS152M, ILE110K, ILE110M, ILE141M, ILE147M, LEU107M, LEU138M, LEU19K, LEU50K, LEU74K, LEU99M, LYS116K, LYS134M, LYS22K, LYS67K, MET13M, PHE111M, PHE68K, PHE71K, PHE81M, PRO117K, PRO136M, PRO151M, PRO46K, SER146M, SER17M, SER47K, SER49K, THR106M, THR109M, THR112M, THR142M, THR95M, TYR103M, TYR118K, TYR139M, TYR143M, VAL102M
• K-E: ALA77E, ALA88K, ARG82E, ARG85K, ARG88E, ARG91K, ARG92K, ARG97K, ASN101K, ASN81E, ASP90K, ASP93K, GLN98K, GLU132K, GLU62E, GLU67E, GLU70E, GLY71E, GLY78E, GLY86K, HIS110E, HIS65E, ILE80E, ILE85E, LEU63E, LEU69E, LEU74E, LYS68E, LYS79E, PHE76E, PHE81K, PRO73E, THR75E, THR84K, THR95K, TYR66E, TYR87K, TYR89K, VAL72E, VAL94K
• K-L: ARG219K, ARG220K, ARG57L, ARG75K, ARG76K, ARG91K, ASP58K, ASP83K, GLU55K, GLU62L, GLU64L, GLU67L, GLU70L, HIS65L, LEU56K, LEU69L, LYS68L, TYR87K
• K-j: ARG14K, ARG465j, ARG509j, ASP459j, ASP461j, GLN11K, GLU10K, GLU15K, GLU18K, GLU512j
• M-L: ARG82L, ARG92M, ARG97M, ASN81L, ASP90M, ASP93M, GLU132M, GLU70L, HIS110L, LYS79L, THR75L, TYR87M, TYR89M
• M-N: ARG219M, ARG220M, ARG57N, ARG75M, ARG76M, ARG91M, ASP58M, ASP83M, GLU55M, GLU62N, GLU64N, GLU67N, GLU70N, HIS65N, LEU56M, LYS68N
• M-j: ARG14M, ARG16M, ARG515j, ARG521j, GLU15M, GLU519j, SER520j
• O-U: ALA100O, ALA104O, ALA115U, ALA12O, ALA148O, ARG135O, ARG140O, ARG14O, ARG16O, ARG16U, ARG26U, ARG48U, ARG75U, ARG76U, ARG85O, ARG97O, ASN101O, ASN69U, ASN73U, ASP144O, ASP149O, ASP72U, GLN105O, GLN114U, GLN11O, GLN51U, GLN98O, GLU10O, GLU113O, GLU113U, GLU119U, GLU137O, GLU150O, GLU15U, GLU18U, GLU70U, GLY108O, GLY145O, GLY96O, ILE110U, ILE141O, ILE147O, LEU107O, LEU138O, LEU19U, LEU50U, LEU74U, LYS116U, LYS134O, LYS22U, LYS67U, MET13O, PHE111O, PHE68U, PHE71U, PHE81O, PRO117U, PRO136O, PRO151O, PRO46U, SER146O, SER47U, SER49U, THR106O, THR109O, THR112O, THR95O, TYR103O, TYR118U, TYR139O, VAL102O
• O-P: ARG219O, ARG220O, ARG57P, ARG75O, ARG76O, ARG91O, ASP39P, ASP58O, ASP83O, GLU55O, GLU62P, GLU64P, GLU67P, GLU70P, HIS65P, LEU56O, LEU69P, LYS68P
• O-V: ARG85O, ARG92O, ARG97O, ASN81V, ASP90O, ASP93O, GLU132O, GLU70V, HIS110V, LYS79V, THR75V, TYR87O
• Q-Y: ALA100Q, ALA104Q, ALA115Y, ALA12Q, ALA12Y, ALA148Q, ALA20Y, ARG135Q, ARG140Q, ARG14Q, ARG14Y, ARG16Q, ARG16Y, ARG26Y, ARG48Y, ARG75Y, ARG76Y, ARG85Q, ARG97Q, ASN101Q, ASN45Y, ASN69Y, ASN73Y, ASP144Q, ASP149Q, ASP72Y, GLN105Q, GLN114Q, GLN114Y, GLN11Q, GLN51Y, GLN80Y, GLN98Q, GLU10Q, GLU113Q, GLU113Y, GLU119Y, GLU137Q, GLU150Q, GLU15Y, GLU18Y, GLU70Y, GLY108Q, GLY145Q, GLY77Y, GLY96Q, ILE110Q, ILE110Y, ILE141Q, ILE147Q, LEU107Q, LEU138Q, LEU19Y, LEU50Y, LEU74Y, LYS116Y, LYS134Q, LYS22Y, LYS67Y, MET13Q, PHE111Q, PHE68Y, PHE71Y, PHE81Q, PRO117Y, PRO136Q, PRO151Q, PRO46Y, SER146Q, SER17Q, SER17Y, SER47Y, SER49Y, THR106Q, THR109Q, THR112Q, THR142Q, THR95Q, TYR103Q, TYR118Y, TYR139Q, TYR143Q, TYR89Q, VAL102Q
• Q-i: ALA164Q, ALA166Q, ALA190Q, ALA25Q, ALA336i, ALA472i, ALA475i, ALA480i, ARG14Q, ARG189Q, ARG21Q, ARG435i, ARG517i, ASN165Q, ASN474i, ASN516i, ASP479i, GLU15Q, GLU161Q, GLU169Q, GLU18Q, GLU432i, GLU473i, GLY337i, GLY431i, HIS452i, ILE163Q, ILE483i, LEU188Q, LEU477i, LYS168Q, LYS22Q, PRO162Q, PRO518i, SER476i, THR159Q, THR160Q, THR478i, TYR335i, TYR430i, TYR471i
• Q-R: ARG219Q, ARG220Q, ARG57R, ARG75Q, ARG76Q, ARG91Q, ASP58Q, ASP83Q, GLU55Q, GLU62R, GLU64R, GLU67R, GLU70R, HIS65R, LEU56Q, LEU69R, LYS68R, TYR87Q
• Q-Z: ALA88Q, ARG82Z, ARG92Q, ARG97Q, ASN81Z, ASP90Q, ASP93Q, GLU132Q, GLU70Z, HIS110Z, LYS79Z, THR75Z, TYR87Q, TYR89Q
• Q-c: ASP413c, GLU10Q
• S-1: ALA1001, ALA1041, ALA115S, ALA121, ALA12S, ALA1481, ARG1351, ARG141, ARG161, ARG16S, ARG26S, ARG48S, ARG75S, ARG76S, ARG851, ARG971, ASN1011, ASN69S, ASN73S, ASP1441, ASP1491, ASP72S, GLN1051, GLN111, GLN1141, GLN114S, GLN51S, GLN80S, GLN981, GLU101, GLU1131, GLU113S, GLU119S, GLU1261, GLU1371, GLU1501, GLU15S, GLU18S, GLU70S, GLY1081, GLY1451, GLY961, ILE1101, ILE110S, ILE1411, ILE1471, LEU1071, LEU1381, LEU19S, LEU50S, LEU74S, LYS116S, LYS1341, LYS22S, LYS67S, MET131, PHE1111, PHE68S, PHE71S, PHE811, PRO117S, PRO1361, PRO1511, PRO46S, SER1461, SER47S, SER49S, THR1061, THR1091, THR1121, THR951, TYR1031, TYR118S, TYR1391, TYR1431, TYR891, VAL1021
• S-J: ARG82J, ARG92S, ARG97S, ASN81J, ASP90S, ASP93S, GLU132S, GLU70J, HIS110J, LYS79J, THR75J, TYR87S, TYR89S
• S-T: ARG219S, ARG220S, ARG57T, ARG75S, ARG76S, ARG91S, ASP58S, ASP83S, GLU55S, GLU62T, GLU64T, GLU67T, GLU70T, HIS65T, LEU56S, LYS68T
• U-1: ALA100U, ALA104U, ALA1151, ALA121, ALA12U, ALA148U, ARG135U, ARG140U, ARG14U, ARG161, ARG16U, ARG2241, ARG261, ARG481, ARG751, ARG761, ARG85U, ARG97U, ASN101U, ASN451, ASN691, ASN731, ASP144U, ASP149U, ASP721, GLN105U, GLN1141, GLN114U, GLN11U, GLN511, GLN98U, GLU10U, GLU1131, GLU113U, GLU1191, GLU126U, GLU137U, GLU150U, GLU151, GLU701, GLY108U, GLY145U, GLY771, GLY96U, HIS152U, ILE1101, ILE141U, ILE147U, LEU107U, LEU138U, LEU191, LEU501, LEU741, LEU99U, LYS1161, LYS134U, LYS221, LYS671, MET13U, PHE111U, PHE681, PHE711, PHE81U, PRO1171, PRO136U, PRO151U, PRO461, SER146U, SER471, SER491, THR106U, THR109U, THR112U, THR142U, THR95U, TYR103U, TYR1181, TYR139U, TYR143U, VAL102U, VAL127U
• U-V: ARG219U, ARG220U, ARG57V, ARG75U, ARG76U, ARG91U, ASP39V, ASP58U, ASP83U, GLU55U, GLU62V, GLU64V, GLU67V, GLU70V, HIS65V, LEU69V, LYS68V
• U-2: ARG822, ARG92U, ARG97U, ASN812, ASP90U, ASP93U, GLU132U, GLU702, HIS1102, LYS792, THR752, TYR87U, TYR89U
• W-Y: ALA100Y, ALA104Y, ALA115W, ALA128Y, ALA148Y, ARG135Y, ARG140Y, ARG16Y, ARG48W, ARG75W, ARG76W, ARG85Y, ARG97Y, ASN101Y, ASN45W, ASN69W, ASN73W, ASP144Y, ASP149Y, ASP72W, GLN105Y, GLN114W, GLN114Y, GLN51W, GLN98Y, GLU10Y, GLU113W, GLU113Y, GLU119W, GLU126Y, GLU137Y, GLU150Y, GLU70W, GLY108Y, GLY145Y, GLY77W, GLY96Y, ILE110W, ILE141Y, ILE147Y, LEU107Y, LEU138Y, LEU50W, LEU74W, LEU99Y, LYS116W, LYS134Y, LYS67W, MET13Y, PHE111Y, PHE68W, PHE71W, PHE81Y, PRO117W, PRO136Y, PRO151Y, PRO46W, SER146Y, SER47W, SER49W, THR106Y, THR109Y, THR112Y, THR142Y, THR95Y, TYR103Y, TYR118W, TYR139Y, TYR143Y, VAL102Y, VAL127Y
• W-G: ALA88W, ARG82G, ARG92W, ARG97W, ASN81G, ASP90W, ASP93W, GLU132W, GLU70G, HIS110G, LYS79G, THR75G, TYR87W
• W-X: ARG219W, ARG220W, ARG57X, ARG75W, ARG76W, ARG91W, ASP58W, ASP83W, GLU55W, GLU62X, GLU64X, GLU67X, GLU70X, HIS65X, LEU69X, LYS68X
• Y-b: ARG189Y, SER528b
• Y-X: ALA88Y, ARG92Y, ARG97Y, ASN81X, ASP90Y, ASP93Y, GLU70X, HIS110X, LYS79X, THR75X, TYR87Y
• Y-Z: ARG219Y, ARG220Y, ARG75Y, ARG76Y, ARG91Y, ASP58Y, ASP83Y, GLU55Y, GLU62Z, GLU64Z, GLU67Z, GLU70Z, HIS65Z, LEU69Z, LYS68Z
• Y-c: ARG14Y, ASP413c, GLU15Y, GLU18Y, LYS22Y, SER412c
• 1-T: ARG851, ARG921, ARG971, ASN81T, ASP901, ASP931, GLU70T, HIS110T, LYS79T, THR75T, TYR871
• 1-2: ARG2201, ARG572, ARG751, ARG761, ARG911, ASP392, ASP581, ASP831, GLU551, GLU622, GLU642, GLU672, GLU702, HIS652, LEU561, LEU692, LYS682
• a-b: ALA312a, ALA312b, ALA320a, ALA400b, ALA404b, ALA415a, ALA448b, ARG314a, ARG314b, ARG316a, ARG316b, ARG326a, ARG348a, ARG375a, ARG376a, ARG385b, ARG397b, ARG435b, ARG440b, ASN345a, ASN369a, ASN373a, ASN401b, ASP372a, ASP444b, ASP449b, GLN311a, GLN311b, GLN351a, GLN398b, GLN405b, GLN414a, GLN414b, GLU310b, GLU315a, GLU318a, GLU370a, GLU413a, GLU413b, GLU419a, GLU426b, GLU437b, GLU450b, GLY377a, GLY396b, GLY408b, GLY445b, HIS452b, ILE410a, ILE410b, ILE441b, ILE447b, LEU319a, LEU350a, LEU374a, LEU399b, LEU407b, LEU438b, LYS322a, LYS367a, LYS416a, LYS434b, MET313b, PHE368a, PHE371a, PHE381b, PHE411b, PRO346a, PRO417a, PRO436b, PRO451b, SER317a, SER347a, SER349a, SER446b, THR395b, THR406b, THR409b, THR412b, THR442b, TYR403b, TYR418a, TYR439b, TYR443b, VAL402b
• a-o: ALA312a, ALA400a, ALA404a, ALA415o, ALA448a, ARG314a, ARG316a, ARG316o, ARG326o, ARG348o, ARG375o, ARG376o, ARG385a, ARG397a, ARG435a, ARG440a, ASN369o, ASN373o, ASN401a, ASP372o, ASP444a, ASP449a, GLN311a, GLN351o, GLN398a, GLN405a, GLN414o, GLU310a, GLU315o, GLU318o, GLU370o, GLU413a, GLU413o, GLU419o, GLU426a, GLU437a, GLU450a, GLY377o, GLY396a, GLY408a, GLY445a, ILE410o, ILE441a, ILE447a, LEU319o, LEU350o, LEU374o, LEU407a, LEU438a, LYS322o, LYS367o, LYS416o, LYS434a, MET313a, PHE368o, PHE371o, PHE381a, PHE411a, PRO346o, PRO417o, PRO436a, PRO451a, SER347o, SER349o, SER446a, THR395a, THR406a, THR409a, THR412a, THR442a, TYR403a, TYR418o, TYR439a, TYR443a, VAL402a
• a-h: ARG357h, ARG375a, ARG376a, ARG391a, ARG519a, ARG520a, ASP358a, ASP383a, GLU355a, GLU362h, GLU364h, GLU367h, GLU370h, HIS365h, LEU369h, LYS368h
• a-p: ARG382p, ARG385a, ARG392a, ARG397a, ASN381p, ASP390a, ASP393a, GLU370p, GLU432a, HIS410p, LYS379p, THR375p, TYR387a, TYR389a
• b-i: ALA312b, ALA312i, ALA400i, ALA404i, ALA415b, ALA448i, ARG314i, ARG316b, ARG316i, ARG326b, ARG348b, ARG375b, ARG376b, ARG385i, ARG397i, ARG435i, ASN369b, ASN373b, ASN401i, ASP372b, ASP444i, ASP449i, GLN311i, GLN351b, GLN398i, GLN405i, GLN414b, GLN414i, GLU310i, GLU315b, GLU318b, GLU370b, GLU413b, GLU413i, GLU419b, GLU437i, GLU450i, GLY377b, GLY396i, GLY408i, GLY445i, ILE410b, ILE441i, ILE447i, LEU319b, LEU350b, LEU374b, LEU407i, LEU438i, LYS322b, LYS367b, LYS416b, LYS434i, MET313i, PHE368b, PHE371b, PHE381i, PHE411i, PRO346b, PRO417b, PRO436i, PRO451i, SER347b, SER349b, SER446i, THR395i, THR406i, THR409i, THR412i, THR442i, TYR389i, TYR403i, TYR418b, TYR439i, TYR443i, VAL402i
• b-h: ALA388b, ARG382h, ARG392b, ARG397b, ASN381h, ASP390b, ASP393b, GLU370h, GLU432b, HIS410h, HIS429b, LYS379h, THR375h, TYR387b, TYR389b
• b-c: ARG357c, ARG375b, ARG376b, ARG391b, ARG519b, ARG520b, ASP339c, ASP358b, ASP383b, GLU355b, GLU362c, GLU364c, GLU367c, GLU370c, HIS365c, LEU356b, LEU369c, LYS368c, TYR387b
• d-k: ALA312d, ALA312k, ALA334k, ALA400k, ALA404k, ALA415d, ALA448k, ARG314k, ARG316d, ARG316k, ARG326d, ARG348d, ARG375d, ARG376d, ARG385k, ARG397k, ARG435k, ARG440k, ASN345d, ASN369d, ASN373d, ASN401k, ASP372d, ASP444k, ASP449k, GLN311k, GLN351d, GLN398k, GLN405k, GLN414d, GLU310k, GLU315d, GLU318d, GLU370d, GLU413d, GLU413k, GLU419d, GLU426k, GLU437k, GLU450k, GLY377d, GLY396k, GLY408k, GLY445k, HIS452k, ILE410d, ILE441k, ILE447k, LEU319d, LEU350d, LEU374d, LEU399k, LEU407k, LEU438k, LYS322d, LYS367d, LYS416d, LYS434k, MET313k, PHE368d, PHE371d, PHE381k, PHE411k, PRO346d, PRO417d, PRO436k, PRO451k, SER347d, SER349d, SER446k, THR395k, THR406k, THR409k, THR412k, THR442k, TYR403k, TYR418d, TYR439k, TYR443k, VAL402k, VAL427k
• d-q: ALA312d, ALA312q, ALA400d, ALA404d, ALA415q, ALA448d, ARG314d, ARG316d, ARG316q, ARG326q, ARG348q, ARG375q, ARG376q, ARG385d, ARG397d, ARG435d, ASN369q, ASN373q, ASN401d, ASP372q, ASP444d, ASP449d, GLN311d, GLN311q, GLN351q, GLN380q, GLN398d, GLN405d, GLN414d, GLN414q, GLU310d, GLU315q, GLU318q, GLU370q, GLU413d, GLU413q, GLU419q, GLU426d, GLU437d, GLU450d, GLY377q, GLY396d, GLY408d, GLY445d, ILE410q, ILE441d, ILE447d, LEU319q, LEU350q, LEU374q, LEU407d, LEU438d, LYS322q, LYS367q, LYS416q, LYS434d, MET313d, PHE368q, PHE371q, PHE381d, PHE411d, PRO346q, PRO417q, PRO436d, PRO451d, SER347q, SER349q, SER446d, THR395d, THR406d, THR409d, THR412d, THR442d, TYR389d, TYR403d, TYR418q, TYR439d, TYR443d, VAL402d
• d-e: ARG375d, ARG376d, ARG519d, ARG520d, ASP339e, ASP358d, ASP383d, GLU355d, GLU362e, GLU364e, GLU367e, GLU370e, HIS365e, LEU369e, LYS368e
• d-r: ARG385d, ARG392d, ARG397d, ASN381-6.9039602.728503, ASP390d, ASP393d, GLU370-2.1228613.264969, GLU370r, HIS410r, LYS379r, THR375-10.1608442.962732, TYR387d
• f-m: ALA312f, ALA312m, ALA320m, ALA400f, ALA404f, ALA415m, ALA448f, ARG314f, ARG316f, ARG316m, ARG326m, ARG348m, ARG375m, ARG376m, ARG385f, ARG397f, ARG435f, ARG440f, ASN369m, ASN373m, ASN401f, ASP372m, ASP444f, ASP449f, GLN311f, GLN311m, GLN351m, GLN398f, GLN405f, GLN414f, GLN414m, GLU310f, GLU315m, GLU318m, GLU370m, GLU413f, GLU413m, GLU419m, GLU437f, GLU450f, GLY377m, GLY408f, GLY445f, ILE410f, ILE410m, ILE441f, ILE447f, LEU319m, LEU350m, LEU374m, LEU407f, LEU438f, LYS322m, LYS367m, LYS416m, LYS434f, MET313f, PHE368m, PHE371m, PHE381f, PHE411f, PRO346m, PRO417m, PRO436f, PRO451f, SER347m, SER349m, SER446f, THR406f, THR409f, THR412f, TYR403f, TYR418m, TYR439f, TYR443f, VAL402f
• f-w: ALA312f, ALA312w, ALA320f, ALA400w, ALA404w, ALA415f, ALA448w, ARG314w, ARG316f, ARG316w, ARG326f, ARG348f, ARG375f, ARG376f, ARG385w, ARG397w, ARG435w, ARG440w, ASN369f, ASN373f, ASN401w, ASP372f, ASP444w, ASP449w, GLN311w, GLN351f, GLN398w, GLN405w, GLN414f, GLN414w, GLU310w, GLU315f, GLU318f, GLU370f, GLU413f, GLU413w, GLU419f, GLU426w, GLU437w, GLU450w, GLY396w, GLY408w, GLY445w, ILE410f, ILE441w, ILE447w, LEU319f, LEU350f, LEU374f, LEU407w, LEU438w, LYS322f, LYS367f, LYS416f, LYS434w, MET313w, PHE368f, PHE371f, PHE381w, PHE411w, PRO346f, PRO417f, PRO436w, PRO451w, SER347f, SER349f, SER446w, THR395w, THR406w, THR409w, THR412w, THR442w, TYR403w, TYR418f, TYR439w, VAL402w
• f-g: ARG357g, ARG375f, ARG376f, ARG391f, ARG520f, ASP339g, ASP358f, ASP383f, GLU355f, GLU362g, GLU364g, GLU367g, GLU370g, HIS365g, LEU356f, LEU369g, LYS368g
• f-n: ALA388f, ARG392f, ARG397f, ASN381n, ASP390f, ASP393f, GLU370n, GLU432f, HIS410n, LYS379n, THR375n, TYR387f
• i-s: ALA312i, ALA312s, ALA334s, ALA400s, ALA404s, ALA415i, ALA448s, ARG314s, ARG316i, ARG316s, ARG326i, ARG348i, ARG375i, ARG376i, ARG385s, ARG397s, ARG435s, ARG440s, ASN345i, ASN369i, ASN373i, ASN401s, ASP372i, ASP444s, ASP449s, GLN311s, GLN351i, GLN398s, GLN405s, GLN414i, GLN414s, GLU310s, GLU315i, GLU318i, GLU370i, GLU413i, GLU413s, GLU419i, GLU426s, GLU437s, GLU450s, GLY377i, GLY396s, GLY408s, GLY445s, HIS452s, ILE410i, ILE441s, ILE447s, LEU319i, LEU350i, LEU374i, LEU399s, LEU407s, LEU438s, LYS322i, LYS367i, LYS416i, LYS434s, MET313s, PHE368i, PHE371i, PHE381s, PHE411s, PRO346i, PRO417i, PRO436s, PRO451s, SER347i, SER349i, SER446s, THR395s, THR406s, THR409s, THR412s, THR442s, TYR403s, TYR418i, TYR439s, TYR443s, VAL402s
• i-c: ARG385i, ARG392i, ARG397i, ASN381c, ASP390i, ASP393i, GLU370c, HIS410c, LYS379c, THR375c, TYR387i
• i-j: ARG375i, ARG376i, ARG519i, ARG520i, ASP358i, ASP383i, GLU355i, GLU362j, GLU364j, GLU367j, GLU370j, HIS365j, LEU356i, LEU369j, LYS368j
• k-m: ALA312k, ALA312m, ALA320k, ALA334m, ALA400m, ALA404m, ALA415k, ALA448m, ARG314k, ARG314m, ARG316k, ARG316m, ARG326k, ARG348k, ARG375k, ARG376k, ARG385m, ARG397m, ARG435m, ARG440m, ARG524k, ASN345k, ASN369k, ASN373k, ASN401m, ASP372k, ASP444m, ASP449m, GLN311k, GLN311m, GLN351k, GLN398m, GLN405m, GLN414k, GLN414m, GLU310m, GLU315k, GLU318k, GLU370k, GLU413k, GLU413m, GLU419k, GLU426m, GLU437m, GLU450m, GLY377k, GLY396m, GLY408m, GLY445m, HIS452m, ILE410k, ILE410m, ILE441m, ILE447m, LEU319k, LEU350k, LEU374k, LEU399m, LEU407m, LEU438m, LYS322k, LYS367k, LYS416k, LYS434m, MET313m, PHE368k, PHE371k, PHE381m, PHE411m, PRO346k, PRO417k, PRO436m, PRO451m, SER317m, SER347k, SER349k, SER446m, THR395m, THR406m, THR409m, THR412m, THR442m, TYR403m, TYR418k, TYR439m, TYR443m, VAL402m
• k-e: ARG382e, ARG392k, ARG397k, ASN381e, ASP390k, ASP393k, GLU370e, GLU432k, HIS410e, LYS379e, THR375e, TYR387k, TYR389k
• k-l: ARG357l, ARG375k, ARG391k, ARG519k, ARG520k, ASP358k, ASP383k, GLU355k, GLU362l, GLU364l, GLU367l, HIS365l, LEU369l, LYS368l, TYR387k
• m-l: ALA388m, ARG392m, ARG397m, ASN381l, ASP390m, ASP393m, GLU370l, GLU432m, HIS410l, LYS379l, THR375l, TYR387m, TYR389m
• m-n: ARG357n, ARG375m, ARG376m, ARG391m, ARG519m, ARG520m, ASP358m, ASP383m, GLU355m, GLU362n, GLU364n, GLU367n, GLU370n, HIS365n, LEU356m, LEU369n, LYS368n
• o-u: ALA312o, ALA400o, ALA404o, ALA415u, ALA448o, ARG314o, ARG316u, ARG326u, ARG348u, ARG375u, ARG376u, ARG385o, ARG397o, ARG435o, ARG440o, ARG524u, ASN369u, ASN373u, ASN401o, ASP372u, ASP444o, ASP449o, GLN311o, GLN351u, GLN398o, GLN405o, GLN414u, GLU310o, GLU315u, GLU318u, GLU370u, GLU413o, GLU413u, GLU419u, GLU426o, GLU437o, GLU450o, GLY377u, GLY396o, GLY408o, GLY445o, ILE410u, ILE441o, ILE447o, LEU319u, LEU350u, LEU374u, LEU407o, LEU438o, LYS322u, LYS367u, LYS416u, LYS434o, MET313o, PHE368u, PHE371u, PHE381o, PHE411o, PRO346u, PRO417u, PRO436o, PRO451o, SER347u, SER349u, SER446o, THR395o, THR406o, THR409o, THR412o, TYR403o, TYR418u, TYR439o, TYR443o, VAL402o
• o-p: ARG357p, ARG375o, ARG376o, ARG391o, ARG519o, ARG520o, ASP339p, ASP358o, ASP383o, GLU355o, GLU362p, GLU364p, GLU367p, GLU370p, HIS365p, LEU369p, LYS368p
• o-v: ARG385o, ARG392o, ARG397o, ASN381v, ASP390o, ASP393o, GLU370v, GLU432o, HIS410v, LYS379v, THR375v, TYR387o, TYR389o
• q-y: ALA312q, ALA400q, ALA404q, ALA415y, ALA448q, ARG314q, ARG316q, ARG316y, ARG326y, ARG348y, ARG375y, ARG376y, ARG385q, ARG397q, ARG435q, ARG440q, ASN369y, ASN373y, ASN401q, ASP372y, ASP444q, ASP449q, GLN311q, GLN311y, GLN351y, GLN398q, GLN405q, GLN414q, GLN414y, GLU310q, GLU315y, GLU318y, GLU370y, GLU413q, GLU413y, GLU419y, GLU437q, GLU450q, GLY377y, GLY396q, GLY408q, GLY445q, ILE410q, ILE410y, ILE441q, ILE447q, LEU319y, LEU350y, LEU374y, LEU407q, LEU438q, LYS322y, LYS367y, LYS416y, LYS434q, MET313q, PHE368y, PHE371y, PHE381q, PHE411q, PRO346y, PRO417y, PRO436q, PRO451q, SER317q, SER347y, SER349y, SER446q, THR406q, THR409q, THR412q, THR442q, TYR403q, TYR418y, TYR439q, TYR443q, VAL402q
• q-r: ARG357r, ARG375q, ARG376q, ARG391q, ARG519q, ARG520q, ASP358q, ASP383q, GLU355q, GLU362r, GLU364-3.2044002.939504, GLU364-7.3560493.197271, GLU364r, GLU367-5.6736723.097265, GLU367-7.3785673.110116, GLU367r, GLU370-3.1954002.729697, GLU370r, HIS365r, LYS368-3.1923503.081940, LYS368-8.0234033.061996, LYS368r
• q-z: ARG382z, ARG392q, ARG397q, ASN381z, ASP390q, ASP393q, GLU370z, GLU432q, HIS410z, LYS379z, THR375z, TYR387q, TYR389q
• s-3: ALA3123, ALA312s, ALA4003, ALA4043, ALA415s, ALA4483, ARG3143, ARG3163, ARG316s, ARG326s, ARG348s, ARG375s, ARG376s, ARG3853, ARG3973, ARG4353, ARG4403, ARG524s, ASN345s, ASN369s, ASN373s, ASN4013, ASP372s, ASP4443, ASP4493, GLN3113, GLN311s, GLN351s, GLN380s, GLN3983, GLN4053, GLN4143, GLN414s, GLU3103, GLU315s, GLU318s, GLU370s, GLU4133, GLU413s, GLU419s, GLU4263, GLU4373, GLU4503, GLY3963, GLY4083, GLY4453, HIS4523, ILE4103, ILE410s, ILE4413, ILE4473, LEU319s, LEU350s, LEU374s, LEU4073, LEU4383, LYS322s, LYS367s, LYS416s, LYS4343, MET3133, PHE368s, PHE371s, PHE3813, PHE4113, PRO346s, PRO417s, PRO4363, PRO4513, SER347s, SER349s, SER4463, THR3953, THR4063, THR4093, THR4123, TYR3893, TYR4033, TYR418s, TYR4393, TYR4433, VAL4023
• s-j: ALA388s, ARG382j, ARG392s, ARG397s, ASN381j, ASP390s, ASP393s, GLU370j, GLU432s, HIS410j, LYS379j, THR375j, TYR387s, TYR389s
• s-t: ARG357t, ARG375s, ARG376s, ARG391s, ARG519s, ARG520s, ASP358s, ASP383s, GLU355s, GLU362t, GLU364t, GLU367t, GLU370t, HIS365t, LEU356s, LEU369t, LYS368t
• u-3: ALA3123, ALA312u, ALA400u, ALA404u, ALA4153, ALA448u, ARG314u, ARG3163, ARG316u, ARG3263, ARG3483, ARG3753, ARG3763, ARG385u, ARG397u, ARG435u, ARG440u, ASN3693, ASN3733, ASN401u, ASP3723, ASP444u, ASP449u, GLN311u, GLN3513, GLN3803, GLN398u, GLN405u, GLN4143, GLN414u, GLU310u, GLU3153, GLU3183, GLU3703, GLU4133, GLU413u, GLU4193, GLU437u, GLU450u, GLY3773, GLY396u, GLY408u, GLY445u, HIS452u, ILE4103, ILE441u, ILE447u, LEU3193, LEU3503, LEU3743, LEU407u, LEU438u, LYS3223, LYS3673, LYS4163, LYS434u, MET313u, PHE3683, PHE3713, PHE381u, PHE411u, PRO3463, PRO4173, PRO436u, PRO451u, SER3473, SER3493, SER446u, THR395u, THR406u, THR409u, THR412u, THR442u, TYR389u, TYR403u, TYR4183, TYR439u, TYR443u, VAL402u
• u-v: ARG357v, ARG375u, ARG376u, ARG391u, ARG520u, ASP339v, ASP358u, ASP383u, GLU355u, GLU362v, GLU364v, GLU367v, GLU370v, HIS365v, LEU369v, LYS368v
• u-4: ARG3824, ARG385u, ARG392u, ARG397u, ASN3814, ASP390u, ASP393u, GLU3704, GLU432u, HIS4104, LYS3794, THR3754, TYR387u
• w-y: ALA312w, ALA312y, ALA320w, ALA400y, ALA404y, ALA415w, ALA428y, ALA448y, ARG314w, ARG314y, ARG316w, ARG316y, ARG326w, ARG348w, ARG375w, ARG376w, ARG385y, ARG397y, ARG435y, ARG440y, ASN345w, ASN369w, ASN373w, ASN401y, ASP372w, ASP393y, ASP444y, ASP449y, GLN311y, GLN351w, GLN398y, GLN405y, GLN414w, GLN414y, GLU310y, GLU315w, GLU318w, GLU370w, GLU413w, GLU413y, GLU419w, GLU426y, GLU437y, GLU450y, GLY377w, GLY396y, GLY408y, GLY445y, ILE410w, ILE441y, ILE447y, LEU319w, LEU350w, LEU374w, LEU399y, LEU407y, LEU438y, LYS322w, LYS367w, LYS416w, LYS434y, MET313y, PHE368w, PHE371w, PHE381y, PHE411y, PRO346w, PRO417w, PRO436y, PRO451y, SER317w, SER347w, SER349w, SER354w, SER446y, THR395y, THR406y, THR409y, THR412y, THR433y, THR442y, TYR403y, TYR418w, TYR439y, TYR443y, VAL402y, VAL427y
• w-g: ARG382g, ARG392w, ARG397w, ASN381g, ASP390w, ASP393w, GLU370g, GLU432w, HIS410g, LYS379g, THR375g, TYR387w
• w-x: ARG357x, ARG375w, ARG376w, ARG391w, ARG519w, ARG520w, ASP358w, ASP383w, GLU355w, GLU362x, GLU364x, GLU367x, GLU370x, HIS365x, LEU369x, LYS368x
• y-x: ARG385y, ARG392y, ARG397y, ASN381x, ASP390y, ASP393y, GLU370x, HIS410x, LYS379x, THR375x, TYR387y
• y-z: ARG375y, ARG376y, ARG519y, ARG520y, ASP358y, ASP383y, GLU355y, GLU362z, GLU364z, GLU367z, GLU370z, HIS365z, LYS368z
• 3-t: ARG3853, ARG3923, ARG3973, ASN381t, ASP3903, ASP3933, GLU370t, GLU4323, HIS410t, LYS379t, THR375t, TYR3873, TYR3893
• 3-4: ARG3574, ARG3753, ARG3763, ARG3913, ARG5193, ARG5203, ASP3583, ASP3833, GLU3553, GLU3624, GLU3644, GLU3674, GLU3704, HIS3654, LYS3684
• H-C: ALA125H, ALA126H, ALA49C, ALA50C, ALA77H, ALA84H, ARG188C, ARG18C, ARG29C, ARG32C, ARG57C, ARG82H, ARG88H, ASN130H, ASN81H, ASP124H, ASP30C, GLN137H, GLN22C, GLU132H, GLU133H, GLU134H, GLU54C, GLY127H, GLY128H, GLY28C, GLY78H, ILE131H, ILE190C, ILE26C, ILE80H, ILE85H, LEU101H, LEU144H, LEU99H, LYS147H, LYS151H, MET25C, PHE123H, PHE55C, SER122H, SER20C, SER27C, THR21C, THR48C, TRP129H, TYR136H, TYR35C, VAL31C, VAL51C, VAL53C
• H-E: ALA146E, ALA146H, ALA170E, ALA170H, ALA174E, ALA174H, ALA175E, ALA175H, ARG221H, ASP173E, ASP173H, ASP176E, ASP176H, ASP177E, ASP177H, ASP178E, ASP178H, GLN156E, GLN156H, GLU134E, GLU134H, GLU169E, GLU169H, GLY142E, GLY142H, LEU144E, LEU144H, LEU153E, LEU153H, LYS147E, LYS147H, LYS151E, LYS151H, LYS152E, LYS152H, MET150E, MET150H, PHE145E, PHE145H, SER141E, SER141H, SER143E, SER143H, SER148E, SER148H, SER149E, SER149H, TYR136E, TYR136H, TYR172E, TYR172H, VAL166E
• H-L: ARG188H, ARG188L, ARG221H, ARG221L, ARG29H, ARG29L, ASN24H, ASN24L, ASP176H, ASP176L, ASP177H, ASP177L, ASP185H, ASP185L, ILE26H, ILE26L, SER179H, SER179L
• H-P: ARG188H, ARG29H, ARG88P, ASP30H, GLU132P, GLU133P, GLU134P, GLU54H
• C-E: ALA174C, ALA174E, ALA175C, ALA175E, ALA180C, ALA180E, ARG188C, ARG188E, ARG19C, ARG19E, ARG221C, ARG221E, ARG29C, ARG29E, ASN24C, ASN24E, ASP173C, ASP173E, ASP176C, ASP176E, ASP177C, ASP177E, ASP178C, ASP178E, ASP185C, ASP185E, GLN22C, GLN22E, GLU219C, GLY142C, GLY142E, GLY182C, GLY189E, GLY23C, GLY23E, GLY28E, ILE217C, ILE218C, ILE26C, ILE26E, LEU144C, LEU144E, LEU186C, LEU186E, MET25C, MET25E, PHE145C, PHE145E, PRO184C, SER141C, SER141E, SER179C, SER179E, SER20C, SER20E, SER220C, SER222C, SER27C, SER27E, THR181C, THR181E, THR21C, THR21E, TYR172C, TYR172E, VAL187C, VAL187E
• C-J: ARG188J, ARG29J, ARG88C, ASP30J, GLU132C, GLU133C, GLU134C, GLU54J
• C-R: ARG221R, ASP173C, ASP173R, ASP176C, ASP176R, ASP177C, ASP177R, LYS147C, LYS147R, LYS151C, LYS151R, LYS152C, LYS152R
• E-L: ARG188L, ARG29L, ARG57L, ARG88E, ASN81E, ASP30L, GLU132E, GLU133E, GLU134E, GLU54L
• E-R: ARG188E, ARG29E, ARG88R, ASP30E, GLU132R, GLU133R, GLU134R, GLU54E
• G-N: ARG188G, ARG29G, ARG88N, ASP30G, GLU132N, GLU133N, GLU134N, GLU54G
• G-V: ARG188G, ARG188V, ARG221G, ARG221V, ARG29G, ARG29V, ASN24G, ASN24V, ASP176G, ASP176V, ASP177G, ASP177V, ASP185G, ASP185V, ILE26G, ILE26V, SER179G, SER179V
• G-X: ARG188X, ARG29X, ARG57X, ARG88G, ASN81G, ASP30X, GLU132G, GLU133G, GLU134G, GLU54X
• G-2: ASP1732, ASP173G, ASP1762, ASP176G, ASP1772, ASP177G, LYS1472, LYS147G, LYS1512, LYS151G, LYS1522, LYS152G
• J-R: ARG188J, ARG188R, ARG221J, ARG221R, ARG29J, ARG29R, ASN24J, ASN24R, ASP176J, ASP176R, ASP177J, ASP177R, ILE26J, ILE26R, SER179J, SER179R
• J-T: ARG188T, ARG29T, ARG57T, ARG88J, ASN81J, ASP30T, GLU132J, GLU133J, GLU134J, GLU54T
• J-Z: ARG221J, ASP173J, ASP173Z, ASP176J, ASP176Z, ASP177J, ASP177Z, LYS147J, LYS147Z, LYS151J, LYS151Z, LYS152J, LYS152Z
• L-N: ARG188N, ARG29N, ARG88L, ASP30N, GLU132L, GLU133L, GLU134L, GLU54N
• L-P: ASP173L, ASP173P, ASP176L, ASP176P, ASP177L, ASP177P, LYS147L, LYS147P, LYS151L, LYS151P, LYS152L, LYS152P
• N-P: ARG188N, ARG188P, ARG221N, ARG221P, ARG29N, ARG29P, ASN24N, ASN24P, ASP176N, ASP176P, ASP177N, ASP177P, ASP185N, ASP185P, ILE26N, ILE26P, SER179N, SER179P
• N-V: ASP173N, ASP173V, ASP176N, ASP176V, ASP177N, ASP177V, LYS147N, LYS147V, LYS151N, LYS151V, LYS152N, LYS152V
• P-V: ARG188P, ARG29P, ARG57P, ARG88V, ASN81V, ASP30P, GLU132V, GLU133V, GLU134V, GLU54P
• R-Z: ARG188R, ARG29R, ARG88Z, ASP30R, GLU132Z, GLU133Z, GLU134Z, GLU54R
• T-X: ASP173T, ASP173X, ASP176T, ASP176X, ASP177T, ASP177X, LYS147T, LYS147X, LYS151T, LYS151X, LYS152T, LYS152X
• T-Z: ARG188T, ARG188Z, ARG221T, ARG221Z, ARG29T, ARG29Z, ASN24Z, ASP176T, ASP176Z, ASP177T, ASP177Z, ASP185T, ASP185Z, ILE26T, ILE26Z, SER179T
• T-2: ARG1882, ARG292, ARG572, ARG88T, ASN81T, ASP302, GLU132T, GLU133T, GLU134T, GLU542
• V-2: ARG188V, ARG29V, ARG57V, ARG882, ASN812, ASP30V, GLU1322, GLU1332, GLU1342, GLU54V
• X-Z: ARG188Z, ARG29Z, ARG88X, ASP30Z, GLU132X, GLU133X, GLU134X, GLU54Z
• X-2: ARG1882, ARG188X, ARG2212, ARG221X, ARG292, ARG29X, ASN242, ASN24X, ASP1762, ASP176X, ASP1772, ASP177X, ASP1852, ASP185X, ILE262, ILE26X, SER1792, SER179X
• h-c: ARG329c, ARG388h, ARG488c, ASP330c, GLU354c, GLU432h, GLU433h, GLU434h
• h-e: ASP473e, ASP473h, ASP476e, ASP476h, ASP477e, ASP477h, LYS447e, LYS447h, LYS451e, LYS451h, LYS452e, LYS452h
• h-l: ARG329h, ARG329l, ARG488h, ARG488l, ARG521h, ARG521l, ASN324h, ASN324l, ASP476h, ASP476l, ASP477h, ASP477l, ASP485h, ASP485l, ILE326h, ILE326l, SER479h, SER479l
• h-p: ARG329h, ARG388p, ARG488h, ASP330h, GLU354h, GLU432p, GLU433p, GLU434p
• c-e: ARG329c, ARG329e, ARG488c, ARG488e, ARG521c, ARG521e, ASN324c, ASN324e, ASP476c, ASP476e, ASP477c, ASP477e, ASP485c, ASP485e, ILE326c, ILE326e, SER479c, SER479e
• c-j: ARG329j, ARG357j, ARG388c, ARG488j, ASN381c, ASP330j, GLU354j, GLU432c, GLU433c, GLU434c
• c-r: ASP473-8.6129912.891796, ASP473c, ASP473r, ASP476-6.1118133.122170, ASP476c, ASP476r, ASP477c, ASP477r, LYS447c, LYS447r, LYS451-3.0626052.922031, LYS451-5.5086123.096102, LYS451c, LYS451r, LYS452-9.5233722.718139, LYS452c, LYS452r
• e-l: ARG329l, ARG388e, ARG488l, ASP330l, GLU354l, GLU432e, GLU433e, GLU434e
• e-r: ARG329e, ARG388r, ARG488e, ASP330e, GLU354e, GLU432r, GLU433r, GLU434-9.0301892.702902, GLU434r
• g-n: ARG329g, ARG388n, ARG488g, ASP330g, GLU354g, GLU432n, GLU433n, GLU434n
• g-v: ARG329g, ARG329v, ARG488g, ARG488v, ARG521g, ARG521v, ASN324g, ASN324v, ASP476g, ASP476v, ASP477g, ASP477v, ASP485g, ASP485v, ILE326g, ILE326v, SER479g, SER479v
• g-x: ARG329x, ARG357x, ARG388g, ARG488x, ASN381g, ASP330x, GLU354x, GLU432g, GLU433g, GLU434g
• g-4: ASP4734, ASP473g, ASP4764, ASP476g, ASP4774, ASP477g, LYS4474, LYS447g, LYS4514, LYS451g, LYS4524, LYS452g
• j-r: ARG329-3.0272892.962276, ARG329j, ARG329r, ARG488-5.0283572.597628, ARG488-5.8385192.763931, ARG488j, ARG488r, ARG521j, ARG521r, ASN324-9.9042263.041750, ASN324j, ASP476-5.4087562.782474, ASP476-5.8006272.701863, ASP476j, ASP476r, ASP477-11.4321602.877593, ASP477-2.5684042.960530, ASP477j, ASP485j, ASP485r, ILE326-11.9564462.896903, ILE326j, SER479-13.2239272.815027, SER479-7.7339362.837250, SER479j
• j-t: ARG329t, ARG357t, ARG388j, ARG488t, ASN381j, ASP330t, GLU354t, GLU432j, GLU433j, GLU434j
• j-z: ASP473j, ASP473z, ASP476j, ASP476z, ASP477j, ASP477z, LYS447j, LYS447z, LYS451j, LYS451z, LYS452j, LYS452z
• l-n: ARG329n, ARG388l, ARG488n, ASP330n, GLU354n, GLU432l, GLU433l, GLU434l
• l-p: ASP473l, ASP473p, ASP476l, ASP476p, ASP477l, ASP477p, LYS447l, LYS447p, LYS451l, LYS451p, LYS452l, LYS452p
• n-p: ARG329n, ARG329p, ARG488n, ARG488p, ARG521n, ARG521p, ASN324n, ASN324p, ASP476n, ASP476p, ASP477n, ASP477p, ASP485n, ASP485p, ILE326n, ILE326p, SER479n, SER479p
• n-v: ASP473n, ASP473v, ASP476n, ASP476v, ASP477n, ASP477v, LYS447n, LYS447v, LYS451n, LYS451v, LYS452n, LYS452v
• p-v: ARG329p, ARG357p, ARG388v, ARG488p, ASN381v, ASP330p, GLU354p, GLU432v, GLU433v, GLU434v
• r-z: ARG329-7.7010712.778144, ARG329r, ARG357-7.1029733.223453, ARG388z, ARG488-7.6252043.211415, ARG488r, ASP330r, GLU354r, GLU432z, GLU433z, GLU434z
• t-x: ASP473t, ASP473x, ASP476t, ASP476x, ASP477t, ASP477x, LYS447t, LYS447x, LYS451t, LYS451x, LYS452t, LYS452x
• t-z: ARG329t, ARG329z, ARG488t, ARG488z, ARG521t, ARG521z, ASN324t, ASN324z, ASP476t, ASP476z, ASP477t, ASP477z, ASP485t, ASP485z, ILE326t, ILE326z, SER479t, SER479z
• t-4: ARG3294, ARG3574, ARG388t, ARG4884, ASN381t, ASP3304, GLU3544, GLU432t, GLU433t, GLU434t
• v-4: ARG329v, ARG357v, ARG3884, ARG488v, ASN3814, ASP330v, GLU354v, GLU4324, GLU4334, GLU4344
• x-z: ARG329z, ARG388x, ARG488z, ASP330z, GLU354z, GLU432x, GLU433x, GLU434x
• x-4: ARG3294, ARG329x, ARG4884, ARG488x, ARG5214, ARG521x, ASN3244, ASN324x, ASP4764, ASP476x, ASP4774, ASP477x, ASP4854, ASP485x, ILE3264, ILE326x, SER4794, SER479x