3HAE

rational development of high-affinity t-cell receptor-like antibodies

• Total interactions analyzed: 190
• Total true interactions: 38
• Strongest Interaction:
  • Chains: R-S
  • Int. Res.: 20
  • Norm. En. per Res.: -3.9457
• Hub Node: J(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.2329	-94.6737	-341.573	-479.4796	128	25	2	13006	4	41	39
A-D	0.0	0.0	-16.8494	-16.8494	19	2	0	736	0	2	3
A-C	-35.9213	0.0	-239.795	-275.7163	85	16	6	9160	0	0	0
A-L	-3.4639	-40.982	-54.2603	-98.7062	49	9	1	2901	4	6	8
A-H	-9.4892	-3.5165	-116.46	-129.4657	68	4	1	4977	0	9	11
D-E	-29.428	-77.7067	-346.013	-453.1478	124	16	2	12792	4	43	40
D-F	-39.3056	0.0	-255.107	-294.4126	86	21	8	9655	0	0	0
D-G	-6.2883	-47.7793	-67.0557	-121.1233	52	5	2	2944	3	7	9
D-I	-11.9709	-3.2048	-112.178	-127.3537	73	13	1	5259	0	10	12
J-K	-45.3701	-78.352	-314.012	-437.7342	127	22	2	12598	3	44	42
J-M	-43.4879	0.0	-239.358	-282.8459	82	20	5	9408	0	0	0
J-G	0.0	0.0	-0.0385	-0.0385	5	0	0	12	0	1	1
J-N	-23.0815	-43.9342	-58.5666	-125.5823	44	6	1	2608	3	7	7
J-H	0.0	0.0	-0.1991	-0.1991	4	0	0	41	0	0	0
J-O	-10.4615	-2.3687	-58.8965	-71.7266	52	2	1	3017	0	9	8
K-I	-22.6782	-18.2476	-76.4582	-117.3839	43	6	0	3425	0	7	8
P-Q	-38.8742	-68.6659	-364.964	-472.5041	126	20	2	12885	4	41	37
P-R	-26.1834	0.0	-259.01	-285.1934	85	10	5	9408	0	0	0
P-G	-7.9578	-0.0093	-33.2744	-41.2416	33	9	0	1903	0	7	6
P-S	-8.4746	-43.4342	-73.3961	-125.3049	55	2	2	3219	4	7	8
P-T	-9.2041	0.3322	-66.6124	-75.4843	50	3	1	3302	0	8	9
C-L	-6.8859	0.0	-58.5234	-65.4093	23	10	0	2318	0	0	0
C-H	-2.697	0.0	-77.4533	-80.1503	32	7	0	2522	0	0	0
F-G	-10.0825	0.0	-67.7735	-77.856	22	6	0	2317	0	0	0
F-I	-17.7509	0.0	-77.7484	-95.4993	30	3	0	2447	0	0	0
M-N	-4.3277	0.0	-63.6947	-68.0224	22	2	0	2175	0	0	0
M-O	-13.1795	0.0	-32.3774	-45.5569	26	2	0	1294	0	0	0
R-S	-11.6065	0.0	-67.3078	-78.9143	20	3	0	2213	0	0	0
R-T	0.0	0.0	-37.3732	-37.3732	26	0	0	1404	0	0	0
L-N	0.0	0.0	-8.8918	-8.8918	31	1	1	727	0	12	11
L-H	-27.5892	-28.3998	-475.214	-531.203	186	14	14	17953	2	21	18
L-O	0.0	0.0	-14.618	-14.618	19	1	0	700	0	2	4
G-I	-22.7987	-17.0842	-445.544	-485.4269	189	18	14	17725	1	25	20
G-T	0.0	1.3048	-3.4186	-2.1138	10	0	0	342	0	2	4
N-H	-7.7049	0.0	-41.5282	-49.2331	25	5	0	1807	0	1	2
N-O	-59.5123	-29.7783	-466.628	-555.9186	192	11	14	17826	2	24	17
S-T	-45.6422	-32.3346	-447.666	-525.6429	187	29	14	17391	2	25	19
H-O	0.0	0.0	-0.0912	-0.0912	3	0	0	24	0	3	1

Interface residues

• A-B: ALA117A, ALA125A, ALA15B, ALA236A, ALA246A, ALA24A, ALA40A, ARG111A, ARG12B, ARG14A, ARG17A, ARG202A, ARG21A, ARG234A, ARG35A, ARG3B, ARG48A, ARG6A, ARG97A, ARG97B, ASN24B, ASP119A, ASP122A, ASP238A, ASP30A, ASP34B, ASP37A, ASP53B, ASP59B, ASP96B, ASP98B, CYS25B, GLN115A, GLN242A, GLN2B, GLN32A, GLN87A, GLN8B, GLN96A, GLU232A, GLU46A, GLU50B, GLY120A, GLY237A, GLY239A, GLY26A, GLY29B, GLY91A, HIS114A, HIS13B, HIS188A, HIS191A, HIS192A, HIS31B, HIS51B, HIS74A, HIS93A, ILE124A, ILE1B, ILE23A, ILE35B, ILE7B, LEU206A, LEU230A, LEU54B, LEU64B, LEU65B, LYS121A, LYS186A, LYS243A, LYS58B, LYS6B, MET0B, MET189A, MET98A, MET99B, PHE22A, PHE22B, PHE241A, PHE30B, PHE36A, PHE56B, PHE62B, PHE8A, PHE9A, PRO14B, PRO235A, PRO32B, SER11A, SER11B, SER207A, SER28B, SER33B, SER52B, SER55B, SER57B, SER61B, SER88A, SER92A, THR10A, THR190A, THR200A, THR233A, THR240A, THR94A, TRP204A, TRP244A, TRP60B, TRP95B, TYR10B, TYR113A, TYR116A, TYR118A, TYR123A, TYR26B, TYR27A, TYR63B, TYR66B, TYR67B, TYR7A, TYR99A, VAL12A, VAL231A, VAL25A, VAL27B, VAL34A, VAL95A, VAL9B
• A-D: ALA139A, ALA139D, ALA140A, ALA140D, ASN86A, ASN86D, ASP137A, ASP137D, GLN141A, GLN141D, HIS145D, LYS144D, MET138A, MET138D, THR142A, THR142D, THR143D, TYR84A, TYR85A
• A-C: ALA117A, ALA139A, ALA140A, ALA150A, ALA158A, ALA24A, ALA69A, ARG157A, ARG170A, ARG65A, ARG6A, ARG75A, ARG82A, ARG97A, ASP77A, CYS164A, GLN155A, GLN72A, GLN8C, GLU166A, GLU55A, GLU63A, GLY100A, GLY26A, GLY62A, GLY79A, HIS114A, HIS151A, HIS70A, HIS74A, ILE124A, ILE52A, ILE6C, LEU156A, LEU160A, LEU168A, LEU2C, LEU3C, LEU78A, LEU81A, LYS144A, LYS146A, LYS66A, LYS68A, MET45A, MET4C, MET5A, PHE22A, PHE33A, PHE36A, PHE8A, PHE9A, SER1C, SER71A, THR142A, THR143A, THR163A, THR64A, THR73A, THR7C, THR80A, TRP133A, TRP147A, TRP167A, TRP51A, TRP5C, TYR113A, TYR116A, TYR118A, TYR123A, TYR159A, TYR171A, TYR59A, TYR7A, TYR84A, TYR85A, TYR99A, VAL152A, VAL25A, VAL28A, VAL34A, VAL67A, VAL76A, VAL95A, VAL9C
• A-L: ALA150A, ALA69A, ALA94L, ARG27L, ARG65A, ARG75A, ASN33L, ASN71L, ASP28L, ASP52L, ASP61A, ASP77A, GLN155A, GLN1L, GLN72A, GLU19A, GLY30L, GLY31L, GLY62A, GLY70L, GLY79A, GLY95L, HIS51L, HIS70A, HIS74A, ILE55L, LEU81A, LYS146A, LYS66A, LYS68A, LYS68L, PHE93L, SER26L, SER36L, SER71A, SER96L, THR64A, THR73A, THR80A, TRP147A, TRP91L, TYR32L, TYR34L, TYR84A, TYR97L, VAL152A, VAL53L, VAL67A, VAL76A
• A-H: ALA149A, ALA150A, ALA158A, ALA31H, ALA59H, ALA69A, ARG170A, ARG44A, ARG65A, ARG67H, ARG72H, ASN74H, ASP61A, ASP62H, CYS164A, GLN155A, GLN72A, GLU148A, GLU154A, GLU166A, GLU58A, GLU63A, GLU99H, GLY105H, GLY52H, GLY55H, GLY56H, GLY57H, GLY62A, GLY66H, HIS151A, HIS70A, ILE51H, ILE70H, LEU100H, LEU101H, LEU156A, LYS146A, LYS65H, LYS66A, LYS68A, MET5A, PHE68H, PRO102H, PRO57A, SER30H, SER50H, SER53H, SER54H, THR163A, THR28H, THR58H, THR64A, THR69H, TRP147A, TRP167A, TRP47H, TRP60A, TYR103H, TYR104H, TYR159A, TYR171A, TYR32H, TYR59A, TYR60H, TYR7A, VAL152A, VAL67A
• D-E: ALA117D, ALA125D, ALA15E, ALA236D, ALA246D, ALA24D, ALA40D, ARG111D, ARG12E, ARG14D, ARG202D, ARG21D, ARG234D, ARG35D, ARG3E, ARG48D, ARG6D, ARG97D, ARG97E, ASN24E, ASP119D, ASP122D, ASP238D, ASP30D, ASP34E, ASP37D, ASP53E, ASP59E, ASP96E, ASP98E, CYS25E, GLN115D, GLN242D, GLN2E, GLN32D, GLN87D, GLN8E, GLN96D, GLU229D, GLU232D, GLU46D, GLU50E, GLY120D, GLY237D, GLY239D, GLY26D, GLY29E, HIS114D, HIS13E, HIS188D, HIS191D, HIS192D, HIS31E, HIS51E, HIS74D, HIS93D, ILE124D, ILE1E, ILE23D, ILE7E, LEU206D, LEU230D, LEU54E, LEU64E, LEU65E, LYS121D, LYS186D, LYS243D, LYS58E, LYS6E, MET0E, MET98D, MET99E, PHE22D, PHE22E, PHE241D, PHE30E, PHE36D, PHE56E, PHE62E, PHE8D, PHE9D, PRO14E, PRO235D, PRO32E, SER11D, SER11E, SER207D, SER28E, SER33E, SER52E, SER55E, SER57E, SER61E, SER92D, THR10D, THR190D, THR200D, THR233D, THR240D, THR94D, TRP204D, TRP244D, TRP60E, TRP95E, TYR10E, TYR113D, TYR116D, TYR118D, TYR123D, TYR26E, TYR27D, TYR63E, TYR66E, TYR67E, TYR7D, TYR99D, VAL12D, VAL231D, VAL25D, VAL27E, VAL34D, VAL95D, VAL9E
• D-F: ALA117D, ALA139D, ALA140D, ALA150D, ALA153D, ALA158D, ALA24D, ALA69D, ARG157D, ARG170D, ARG35D, ARG65D, ARG6D, ARG82D, ARG97D, ASP77D, CYS164D, GLN155D, GLN72D, GLN8F, GLU148D, GLU55D, GLU63D, GLY100D, GLY26D, GLY62D, GLY79D, HIS114D, HIS151D, HIS70D, HIS74D, ILE124D, ILE52D, ILE6F, LEU156D, LEU160D, LEU168D, LEU2F, LEU3F, LEU78D, LEU81D, LYS144D, LYS146D, LYS66D, LYS68D, MET45D, MET4F, MET5D, PHE22D, PHE33D, PHE36D, PHE8D, PHE9D, SER1F, SER71D, THR142D, THR143D, THR163D, THR64D, THR73D, THR7F, THR80D, TRP133D, TRP147D, TRP167D, TRP51D, TRP5F, TYR113D, TYR116D, TYR118D, TYR123D, TYR159D, TYR171D, TYR59D, TYR7D, TYR84D, TYR85D, TYR99D, VAL152D, VAL25D, VAL28D, VAL34D, VAL67D, VAL76D, VAL95D, VAL9F
• D-G: ALA150D, ALA69D, ALA94G, ARG27G, ARG65D, ARG75D, ARG97D, ASN33G, ASP28G, ASP52G, ASP77D, GLN155D, GLN1G, GLN72D, GLU19D, GLY30G, GLY31G, GLY79D, GLY95G, HIS151D, HIS51G, HIS70D, HIS74D, ILE55G, LEU156D, LEU81D, LYS146D, LYS66D, LYS68D, LYS68G, PHE93G, SER26G, SER36G, SER71D, SER96G, THR142D, THR143D, THR25G, THR64D, THR73D, THR80D, TRP147D, TRP91G, TYR32G, TYR34G, TYR84D, TYR97G, TYR98G, VAL152D, VAL53G, VAL67D, VAL76D
• D-I: ALA149D, ALA150D, ALA158D, ALA31I, ALA59I, ALA61I, ALA69D, ARG170D, ARG65D, ARG67I, ARG72I, ASN74I, ASP61D, ASP62I, CYS164D, GLN155D, GLN72D, GLU148D, GLU154D, GLU166D, GLU55D, GLU58D, GLU63D, GLU99I, GLY105I, GLY162D, GLY52I, GLY55I, GLY56I, GLY57I, GLY62D, GLY66I, HIS151D, HIS70D, ILE51I, ILE70I, LEU100I, LEU101I, LEU156D, LYS146D, LYS65I, LYS66D, LYS68D, MET5D, PRO102I, PRO57D, SER30I, SER49I, SER50I, SER53I, SER54I, SER71D, THR163D, THR28I, THR58I, THR64D, THR69I, THR73D, TRP147D, TRP167D, TRP47I, TRP60D, TYR103I, TYR104I, TYR159D, TYR171D, TYR32I, TYR59D, TYR60I, TYR7D, TYR99D, VAL152D, VAL67D
• J-K: ALA117J, ALA125J, ALA15K, ALA236J, ALA246J, ALA24J, ALA40J, ARG111J, ARG12K, ARG14J, ARG17J, ARG202J, ARG21J, ARG234J, ARG35J, ARG3K, ARG48J, ARG6J, ARG97J, ARG97K, ASN24K, ASP119J, ASP122J, ASP238J, ASP30J, ASP34K, ASP37J, ASP53K, ASP59K, ASP96K, ASP98K, CYS203J, CYS25K, GLN115J, GLN242J, GLN2K, GLN32J, GLN87J, GLN8K, GLN96J, GLU229J, GLU232J, GLU46J, GLU50K, GLY120J, GLY237J, GLY239J, GLY26J, GLY29K, GLY91J, HIS114J, HIS13K, HIS188J, HIS191J, HIS192J, HIS31K, HIS51K, HIS74J, HIS93J, ILE124J, ILE1K, ILE23J, ILE7K, LEU206J, LEU54K, LEU64K, LEU65K, LYS121J, LYS186J, LYS243J, LYS58K, LYS6K, MET0K, MET98J, MET99K, PHE22J, PHE22K, PHE241J, PHE30K, PHE36J, PHE56K, PHE62K, PHE8J, PHE9J, PRO14K, PRO235J, PRO32K, PRO47J, SER11J, SER11K, SER207J, SER28K, SER33K, SER52K, SER55K, SER57K, SER61K, SER92J, THR10J, THR190J, THR200J, THR233J, THR240J, THR94J, TRP204J, TRP244J, TRP60K, TRP95K, TYR10K, TYR113J, TYR116J, TYR118J, TYR123J, TYR26K, TYR27J, TYR63K, TYR66K, TYR67K, TYR7J, TYR99J, VAL12J, VAL231J, VAL25J, VAL27K, VAL34J, VAL95J, VAL9K
• J-M: ALA140J, ALA150J, ALA158J, ALA24J, ALA69J, ARG157J, ARG170J, ARG65J, ARG6J, ARG82J, ARG97J, ASP77J, CYS164J, GLN155J, GLN72J, GLN8M, GLU148J, GLU166J, GLU55J, GLU63J, GLY100J, GLY26J, GLY62J, GLY79J, HIS114J, HIS151J, HIS70J, HIS74J, ILE124J, ILE52J, ILE6M, LEU156J, LEU160J, LEU168J, LEU2M, LEU3M, LEU78J, LEU81J, LYS144J, LYS146J, LYS66J, LYS68J, MET45J, MET4M, MET5J, PHE22J, PHE33J, PHE36J, PHE8J, PHE9J, SER1M, SER71J, THR142J, THR143J, THR163J, THR64J, THR73J, THR7M, THR80J, TRP133J, TRP147J, TRP167J, TRP51J, TRP5M, TYR113J, TYR116J, TYR118J, TYR123J, TYR159J, TYR171J, TYR59J, TYR7J, TYR84J, TYR99J, VAL152J, VAL25J, VAL28J, VAL34J, VAL67J, VAL76J, VAL95J, VAL9M
• J-G: ALA130G, ASN131G, ASP196J, HIS197J, LYS132G
• J-N: ALA150J, ALA69J, ARG27N, ARG65J, ARG75J, ASN33N, ASN71N, ASP28N, ASP52N, ASP61J, GLN155J, GLN1N, GLN72J, GLU63J, GLY30N, GLY31N, GLY62J, GLY95N, HIS51N, HIS70J, HIS74J, ILE55N, LYS146J, LYS66J, LYS68J, LYS68N, PHE93N, SER26N, SER36N, SER71J, SER96N, THR25N, THR64J, THR73J, THR80J, TRP91N, TYR32N, TYR34N, TYR84J, TYR97N, VAL152J, VAL53N, VAL67J, VAL76J
• J-H: ARG44J, ASP61J, GLN13H, PRO57J
• J-O: ALA149J, ALA150J, ALA158J, ALA31O, ALA59O, ALA69J, ARG170J, ARG44J, ARG65J, ASP61J, ASP62O, GLN155J, GLN72J, GLU154J, GLU166J, GLU58J, GLU63J, GLU99O, GLY105O, GLY162J, GLY52O, GLY55O, GLY56O, GLY57O, GLY62J, GLY66O, HIS151J, HIS70J, LEU100O, LEU101O, LYS65O, LYS66J, LYS68J, PRO102O, PRO57J, SER53O, SER54O, THR163J, THR28O, THR58O, THR64J, TRP167J, TRP47O, TRP60J, TYR103O, TYR104O, TYR159J, TYR32O, TYR59J, TYR60O, VAL152J, VAL67J
• K-I: ALA120I, ALA79K, ALA88I, ARG19I, ARG45K, ARG67I, ARG81K, ARG87I, ASN42K, ASN83K, ASN84I, CYS80K, GLN13I, GLN82I, GLN89K, GLU44K, GLU77K, GLU89I, GLY15I, GLY16I, GLY43K, GLY8I, ILE92K, LEU18I, LEU20I, LEU40K, LEU81I, LEU86I, LYS41K, LYS91K, LYS94K, MET83I, PRO14I, PRO90K, SER118I, SER119I, SER17I, SER85I, SER88K, VAL117I, VAL12I, VAL82K, VAL93K
• P-Q: ALA117P, ALA125P, ALA236P, ALA246P, ALA24P, ALA40P, ARG111P, ARG12Q, ARG202P, ARG21P, ARG234P, ARG35P, ARG3Q, ARG48P, ARG6P, ARG97P, ARG97Q, ASN21Q, ASN24Q, ASP119P, ASP122P, ASP238P, ASP30P, ASP34Q, ASP37P, ASP53Q, ASP59Q, ASP96Q, ASP98Q, CYS203P, CYS25Q, GLN115P, GLN242P, GLN2Q, GLN32P, GLN87P, GLN8Q, GLN96P, GLU232P, GLU46P, GLU50Q, GLY120P, GLY237P, GLY239P, GLY26P, GLY29Q, GLY91P, HIS114P, HIS13Q, HIS188P, HIS191P, HIS192P, HIS31Q, HIS51Q, HIS74P, HIS93P, ILE124P, ILE1Q, ILE23P, ILE7Q, LEU206P, LEU230P, LEU54Q, LEU64Q, LEU65Q, LYS121P, LYS186P, LYS243P, LYS58Q, LYS6Q, MET0Q, MET189P, MET98P, MET99Q, PHE22P, PHE22Q, PHE241P, PHE30Q, PHE36P, PHE56Q, PHE62Q, PHE8P, PHE9P, PRO14Q, PRO235P, PRO32Q, SER11P, SER11Q, SER13P, SER207P, SER28Q, SER33Q, SER52Q, SER55Q, SER57Q, SER61Q, SER92P, THR10P, THR190P, THR200P, THR233P, THR240P, THR94P, TRP204P, TRP244P, TRP60Q, TRP95Q, TYR10Q, TYR113P, TYR116P, TYR118P, TYR123P, TYR26Q, TYR27P, TYR63Q, TYR66Q, TYR67Q, TYR7P, TYR99P, VAL12P, VAL231P, VAL25P, VAL27Q, VAL34P, VAL95P, VAL9Q
• P-R: ALA117P, ALA139P, ALA140P, ALA150P, ALA153P, ALA158P, ALA24P, ALA69P, ARG157P, ARG170P, ARG65P, ARG6P, ARG82P, ARG97P, ASP77P, CYS164P, GLN155P, GLN72P, GLN8R, GLU148P, GLU166P, GLU55P, GLU63P, GLY100P, GLY26P, GLY62P, GLY79P, HIS114P, HIS151P, HIS70P, HIS74P, ILE124P, ILE52P, ILE6R, LEU156P, LEU160P, LEU168P, LEU2R, LEU3R, LEU78P, LEU81P, LYS144P, LYS146P, LYS66P, LYS68P, MET45P, MET4R, MET5P, PHE22P, PHE33P, PHE36P, PHE8P, PHE9P, SER1R, SER71P, THR142P, THR143P, THR163P, THR64P, THR73P, THR7R, THR80P, TRP133P, TRP147P, TRP167P, TRP5R, TYR113P, TYR116P, TYR118P, TYR123P, TYR159P, TYR171P, TYR59P, TYR7P, TYR84P, TYR85P, TYR99P, VAL152P, VAL25P, VAL28P, VAL34P, VAL67P, VAL76P, VAL95P, VAL9R
• P-G: ARG108P, ARG157P, ARG169P, ARG56G, ARG63G, ASP106P, ASP62G, GLN16G, GLU161P, GLU166P, GLY104P, GLY15G, GLY162P, GLY79G, ILE77G, LEU110P, LEU75G, LEU80G, PHE109P, PHE64G, PRO14G, SER105P, SER17G, SER65G, SER67G, SER74G, SER78G, THR19G, THR76G, TRP107P, VAL103P, VAL165P, VAL18G
• P-S: ALA150P, ALA69P, ALA94S, ARG27S, ARG65P, ARG75P, ARG97P, ASN33S, ASN71S, ASP28S, ASP52S, ASP61P, ASP77P, GLN155P, GLN1S, GLN43P, GLN72P, GLY30S, GLY31S, GLY62P, GLY70S, GLY79P, GLY95S, HIS51S, HIS70P, HIS74P, ILE55S, LEU48S, LEU81P, LYS146P, LYS66P, LYS68P, LYS68S, PHE93S, SER26S, SER36S, SER71P, SER96S, THR143P, THR25S, THR64P, THR73P, THR80P, TRP147P, TRP91S, TYR32S, TYR34S, TYR84P, TYR97S, VAL152P, VAL29S, VAL35S, VAL53S, VAL67P, VAL76P
• P-T: ALA149P, ALA150P, ALA158P, ALA31T, ALA59T, ALA69P, ARG44P, ARG65P, ASP61P, ASP62T, GLN155P, GLU154P, GLU166P, GLU58P, GLU63P, GLU99T, GLY105T, GLY162P, GLY52T, GLY55T, GLY56T, GLY57T, GLY62P, GLY66T, HIS151P, HIS70P, LEU100T, LEU101T, LYS65T, LYS66P, LYS68P, PRO102T, PRO57P, SER53T, SER54T, THR163P, THR28T, THR58T, THR64P, THR73P, TRP167P, TRP47T, TRP60P, TYR103T, TYR104T, TYR159P, TYR59P, TYR60T, VAL152P, VAL67P
• C-L: ALA94L, ARG27L, ASP28L, GLN8C, GLY31L, GLY95L, ILE6C, LEU3C, MET4C, PHE93L, SER26L, SER92L, SER96L, THR25L, THR7C, TRP5C, TRP91L, TYR32L, TYR34L, TYR97L, TYR98L, VAL99L, VAL9C
• C-H: ALA59H, GLU99H, GLY105H, GLY33H, GLY35H, GLY52H, GLY55H, GLY56H, GLY57H, ILE51H, ILE6C, ILE70H, LEU101H, LEU2C, LEU3C, LYS65H, MET106H, MET34H, MET4C, PRO102H, SER1C, SER49H, SER50H, SER53H, SER54H, THR58H, THR7C, TRP47H, TRP5C, TYR103H, TYR104H, TYR60H
• F-G: ALA94G, ARG27G, ASP28G, GLN8F, GLY31G, GLY95G, ILE6F, LEU3F, MET4F, PHE93G, SER26G, SER92G, SER96G, THR25G, THR7F, TRP5F, TRP91G, TYR32G, TYR97G, TYR98G, VAL99G, VAL9F
• F-I: ALA59I, GLU99I, GLY105I, GLY33I, GLY35I, GLY52I, GLY55I, GLY56I, GLY57I, ILE51I, ILE6F, ILE70I, LEU101I, LEU2F, LEU3F, MET106I, MET34I, MET4F, PRO102I, SER1F, SER49I, SER50I, SER53I, SER54I, THR58I, TRP47I, TRP5F, TYR103I, TYR104I, TYR60I
• M-N: ALA94N, ARG27N, ASP28N, GLN8M, GLY31N, GLY95N, ILE6M, LEU3M, MET4M, PHE93N, SER26N, SER92N, SER96N, THR25N, THR7M, TRP5M, TRP91N, TYR32N, TYR34N, TYR97N, TYR98N, VAL9M
• M-O: ALA59O, GLU99O, GLY105O, GLY33O, GLY52O, GLY56O, GLY57O, ILE51O, ILE6M, LEU101O, LEU2M, LEU3M, MET106O, MET34O, MET4M, PRO102O, SER1M, SER49O, SER50O, SER53O, THR58O, TRP47O, TRP5M, TYR103O, TYR104O, TYR60O
• R-S: ALA94S, ARG27S, ASP28S, GLN8R, GLY31S, GLY95S, ILE6R, LEU3R, MET4R, PHE93S, SER26S, SER96S, THR25S, THR7R, TRP5R, TRP91S, TYR32S, TYR97S, TYR98S, VAL9R
• R-T: ALA59T, GLU99T, GLY105T, GLY33T, GLY52T, GLY56T, GLY57T, ILE51T, ILE6R, LEU101T, LEU2R, LEU3R, MET106T, MET34T, MET4R, PRO102T, SER1R, SER49T, SER50T, SER53T, THR58T, TRP47T, TRP5R, TYR103T, TYR104T, TYR60T
• L-N: ALA160L, ALA82N, ARG63N, ASN131L, ASN172N, ASP141N, ASP62N, GLN170N, GLN187L, GLN81N, GLU163L, GLU186L, GLU83N, GLY161L, HIS191L, LEU183L, LEU80N, LYS132L, LYS159L, LYS174N, LYS44N, LYS47N, PRO14N, PRO185L, PRO61N, SER171N, SER182L, SER190L, THR184L, VAL158L, VAL162L
• L-H: ALA130L, ALA131H, ALA133L, ALA142H, ALA143H, ALA174H, ALA176L, ALA177L, ALA210L, ALA45L, ALA59H, ALA61H, ALA94L, ALA97H, ARG38H, ARG56L, ASN131L, ASN172L, ASN33L, ASP107H, ASP141L, ASP150H, ASP52L, ASP62H, CYS137L, CYS146H, CYS90L, CYS96H, GLN111H, GLN129L, GLN170L, GLN177H, GLN1L, GLN39H, GLN39L, GLN40L, GLU126L, GLU127L, GLU163L, GLU3L, GLU46H, GLU6H, GLU99H, GLY101L, GLY103L, GLY105H, GLY110H, GLY112H, GLY145H, GLY161L, GLY180H, GLY33H, GLY35H, GLY42H, GLY43L, GLY44H, GLY52H, GLY57H, GLY95L, GLY98H, HIS170H, HIS41L, HIS51L, HIS87L, ILE139L, ILE49L, ILE50L, ILE51H, ILE55L, LEU100H, LEU101H, LEU120L, LEU128L, LEU130H, LEU135L, LEU138L, LEU144H, LEU147H, LEU176H, LEU181L, LEU183L, LEU184H, LEU45H, LEU48L, LYS132L, LYS135H, LYS149H, LYS166L, LYS169L, LYS174L, LYS207L, LYS215H, LYS220H, LYS43H, LYS44L, LYS47L, LYS65H, MET106H, MET34H, PHE100L, PHE121L, PHE128H, PHE142L, PHE172H, PHE93L, PRO102H, PRO122L, PRO123L, PRO129H, PRO132H, PRO167L, PRO173H, PRO46L, PRO57L, SER124L, SER125L, SER126H, SER133H, SER136H, SER140L, SER168L, SER171L, SER178H, SER178L, SER179H, SER179L, SER182L, SER183H, SER185H, SER186H, SER2L, SER36L, SER49H, SER50H, SER58L, SER63H, SER92L, SER96L, THR102L, THR117L, THR119L, THR134L, THR164L, THR165L, THR171H, THR189H, THR208L, THR58H, TRP109H, TRP36H, TRP37L, TRP47H, TRP91L, TYR103H, TYR104H, TYR151H, TYR175L, TYR180L, TYR182H, TYR32L, TYR34L, TYR38L, TYR60H, TYR88L, TYR89L, TYR95H, TYR97L, TYR98L, VAL108H, VAL118L, VAL127H, VAL136L, VAL148H, VAL162L, VAL175H, VAL187H, VAL188H, VAL209L, VAL217H, VAL35L, VAL37H, VAL48H, VAL53L, VAL64H, VAL93H, VAL99L
• L-O: ALA164O, ARG192L, ASN131L, GLN111O, GLU186L, GLY168O, HIS170O, HIS191L, LEU128L, LEU165O, LYS189L, PRO185L, PRO211L, SER167O, SER190L, THR166O, THR171O, TRP188L, VAL169O
• G-I: ALA130G, ALA131I, ALA133G, ALA142I, ALA143I, ALA174I, ALA176G, ALA177G, ALA210G, ALA45G, ALA59I, ALA61I, ALA94G, ALA97I, ARG38I, ARG56G, ASN131G, ASN172G, ASN33G, ASP107I, ASP141G, ASP150I, ASP52G, ASP62I, CYS137G, CYS146I, CYS90G, CYS96I, GLN111I, GLN129G, GLN170G, GLN177I, GLN1G, GLN39G, GLN39I, GLN40G, GLU126G, GLU127G, GLU163G, GLU3G, GLU46I, GLU6I, GLU99I, GLY101G, GLY103G, GLY105I, GLY110I, GLY112I, GLY145I, GLY161G, GLY33I, GLY35I, GLY42I, GLY43G, GLY44I, GLY52I, GLY95G, GLY98I, HIS170I, HIS51G, HIS87G, ILE139G, ILE49G, ILE50G, ILE51I, ILE55G, LEU100I, LEU101I, LEU120G, LEU128G, LEU130I, LEU135G, LEU138G, LEU144I, LEU147I, LEU176I, LEU181G, LEU181I, LEU183G, LEU184I, LEU45I, LEU48G, LYS132G, LYS135I, LYS149I, LYS166G, LYS169G, LYS174G, LYS207G, LYS215I, LYS216I, LYS220I, LYS43I, LYS44G, LYS47G, LYS65I, MET106I, MET34I, PHE100G, PHE121G, PHE128I, PHE142G, PHE172I, PHE93G, PRO102I, PRO122G, PRO123G, PRO129I, PRO132I, PRO167G, PRO173I, PRO211G, PRO42G, PRO46G, PRO57G, SER124G, SER125G, SER126I, SER133I, SER136I, SER140G, SER168G, SER171G, SER178G, SER178I, SER179G, SER179I, SER182G, SER183I, SER185I, SER186I, SER2G, SER36G, SER49I, SER50I, SER58G, SER63I, SER92G, SER96G, THR102G, THR117G, THR119G, THR134G, THR164G, THR165G, THR171I, THR189I, THR208G, THR58I, TRP109I, TRP188G, TRP36I, TRP37G, TRP47I, TRP91G, TYR103I, TYR104I, TYR175G, TYR180G, TYR182I, TYR32G, TYR34G, TYR38G, TYR60I, TYR88G, TYR89G, TYR95I, TYR97G, TYR98G, VAL108I, VAL118G, VAL127I, VAL136G, VAL148I, VAL162G, VAL175I, VAL187I, VAL188I, VAL209G, VAL213I, VAL217I, VAL35G, VAL37I, VAL48I, VAL53G, VAL60G, VAL64I, VAL93I, VAL99G
• G-T: ALA114G, ARG19T, ASN115G, ASP73T, GLN111G, LYS113G, LYS76T, PRO112G, SER75T, TYR80T
• N-H: ALA120H, ARG56N, ARG63N, ASP150H, ASP62N, GLN177H, GLN81N, GLY180H, GLY59N, HIS51N, ILE55N, LEU181H, LYS123H, LYS47N, PHE152H, PHE64N, PRO57N, PRO61N, SER119H, SER121H, SER178H, SER179H, SER58N, THR122H, VAL60N
• N-O: ALA130N, ALA131O, ALA133N, ALA142O, ALA143O, ALA174O, ALA176N, ALA177N, ALA210N, ALA45N, ALA59O, ALA61O, ALA94N, ALA97O, ARG38O, ARG56N, ASN131N, ASN172N, ASN33N, ASP107O, ASP141N, ASP150O, ASP52N, ASP62O, CYS137N, CYS146O, CYS90N, CYS96O, GLN111O, GLN129N, GLN170N, GLN177O, GLN1N, GLN39N, GLN39O, GLN40N, GLN6N, GLU126N, GLU127N, GLU163N, GLU3N, GLU46O, GLU6O, GLU99O, GLY101N, GLY103N, GLY105O, GLY110O, GLY112O, GLY145O, GLY161N, GLY180O, GLY33O, GLY35O, GLY42O, GLY43N, GLY44O, GLY52O, GLY95N, GLY98O, HIS170O, HIS41N, HIS51N, HIS87N, ILE139N, ILE49N, ILE50N, ILE51O, ILE55N, LEU100O, LEU101O, LEU120N, LEU128N, LEU130O, LEU135N, LEU138N, LEU144O, LEU147O, LEU176O, LEU181N, LEU181O, LEU183N, LEU184O, LEU45O, LEU48N, LYS123O, LYS132N, LYS135O, LYS149O, LYS166N, LYS169N, LYS174N, LYS207N, LYS215O, LYS220O, LYS43O, LYS44N, LYS47N, LYS65O, MET106O, MET34O, PHE100N, PHE121N, PHE128O, PHE142N, PHE172O, PHE93N, PRO102O, PRO122N, PRO123N, PRO129O, PRO132O, PRO167N, PRO173O, PRO211N, PRO41O, PRO42N, PRO46N, PRO57N, SER124N, SER125N, SER126O, SER133O, SER134O, SER136O, SER140N, SER168N, SER171N, SER178N, SER178O, SER179N, SER179O, SER182N, SER183O, SER185O, SER186O, SER2N, SER36N, SER49O, SER50O, SER58N, SER63O, SER92N, SER96N, THR102N, THR117N, THR119N, THR134N, THR164N, THR165N, THR171O, THR189O, THR208N, THR58O, TRP109O, TRP36O, TRP37N, TRP47O, TRP91N, TYR103O, TYR104O, TYR151O, TYR175N, TYR180N, TYR182O, TYR32N, TYR34N, TYR38N, TYR60O, TYR88N, TYR89N, TYR95O, TYR97N, TYR98N, VAL108O, VAL118N, VAL127O, VAL136N, VAL148O, VAL162N, VAL175O, VAL187O, VAL188O, VAL209N, VAL217O, VAL35N, VAL37O, VAL48O, VAL53N, VAL64O, VAL93O, VAL99N
• S-T: ALA130S, ALA131T, ALA133S, ALA142T, ALA143T, ALA174T, ALA176S, ALA177S, ALA210S, ALA45S, ALA59T, ALA61T, ALA94S, ALA97T, ARG38T, ARG56S, ASN172S, ASN33S, ASP107T, ASP141S, ASP150T, ASP52S, ASP62T, CYS137S, CYS146T, CYS90S, CYS96T, GLN111T, GLN129S, GLN170S, GLN177T, GLN1S, GLN39S, GLN39T, GLN40S, GLU126S, GLU127S, GLU163S, GLU3S, GLU46T, GLU6T, GLU99T, GLY101S, GLY103S, GLY105T, GLY110T, GLY112T, GLY145T, GLY161S, GLY180T, GLY33T, GLY35T, GLY42T, GLY43S, GLY44T, GLY57T, GLY95S, GLY98T, HIS170T, HIS41S, HIS51S, HIS87S, ILE139S, ILE49S, ILE50S, ILE51T, ILE55S, LEU100T, LEU101T, LEU120S, LEU128S, LEU130T, LEU135S, LEU138S, LEU144T, LEU147T, LEU176T, LEU181S, LEU181T, LEU183S, LEU184T, LEU45T, LEU48S, LYS132S, LYS135T, LYS149T, LYS166S, LYS169S, LYS174S, LYS207S, LYS215T, LYS216T, LYS220T, LYS43T, LYS44S, LYS47S, LYS65T, MET106T, MET34T, PHE100S, PHE121S, PHE128T, PHE142S, PHE172T, PHE93S, PRO102T, PRO122S, PRO123S, PRO129T, PRO132T, PRO167S, PRO173T, PRO46S, PRO57S, SER124S, SER125S, SER126T, SER133T, SER136T, SER140S, SER168S, SER171S, SER178S, SER178T, SER179S, SER179T, SER182S, SER183T, SER185T, SER186T, SER2S, SER36S, SER49T, SER50T, SER58S, SER63T, SER92S, SER96S, THR102S, THR104S, THR117S, THR119S, THR134S, THR164S, THR165S, THR171T, THR189T, THR208S, THR58T, TRP109T, TRP36T, TRP37S, TRP47T, TRP91S, TYR103T, TYR104T, TYR175S, TYR180S, TYR182T, TYR32S, TYR34S, TYR38S, TYR60T, TYR88S, TYR89S, TYR95T, TYR97S, TYR98S, VAL108T, VAL118S, VAL127T, VAL136S, VAL148T, VAL162S, VAL175T, VAL187T, VAL188T, VAL209S, VAL213T, VAL217T, VAL35S, VAL37T, VAL48T, VAL53S, VAL64T, VAL93T, VAL99S
• H-O: LEU100O, SER121H, TYR104O