3H3V

yeast rnap ii containing poly(a)-signal sequence in the active site

• Total interactions analyzed: 105
• Total true interactions: 29
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 778
  • Norm. En. per Res.: -4.0236
• Hub Node: C(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-C	-368.9208	-289.8867	-2471.54	-3130.3475	778	275	62	110309	25	264	236
B-D	-20.8186	1.0586	-56.0555	-75.8155	46	8	0	3018	0	17	19
B-E	0.0	-9.3698	-17.3901	-26.7599	26	1	1	1060	0	11	5
B-F	-68.6559	-75.3252	-510.523	-654.5041	197	65	15	23728	5	77	61
B-G	-83.1304	-58.356	-506.507	-647.9933	177	43	15	22049	3	63	53
B-H	-10.0602	-57.4133	-123.225	-190.6985	63	13	5	5745	2	22	17
B-I	-42.2554	-3.2105	-355.773	-401.2389	138	60	13	17185	1	36	36
B-J	-109.2406	-25.4696	-415.043	-549.7533	138	53	11	17317	5	55	48
B-L	-23.1331	-26.5117	-234.915	-284.5598	90	22	8	9944	3	23	19
C-D	-57.3852	-99.6811	-438.7	-595.7663	170	57	4	18162	7	59	60
C-E	0.0	-6.5746	-40.1331	-46.7077	33	4	1	2237	0	17	19
C-F	0.0	0.0	-6.5244	-6.5244	8	2	0	348	0	2	1
C-G	0.0	0.0	-10.5016	-10.5016	24	1	0	446	0	5	5
C-H	-6.5929	0.0	-6.6613	-13.2541	27	0	0	674	0	7	4
C-I	0.0	0.0	-0.871	-0.871	2	0	0	53	0	0	0
C-J	-3.1505	-72.8797	-265.335	-341.3652	135	24	2	13284	5	51	48
C-K	-21.3243	-27.6451	-388.422	-437.3914	139	40	5	18460	3	35	36
C-L	-7.4409	-10.7987	-76.5365	-94.776	57	11	0	3476	2	15	17
C-M	-63.7377	-72.2341	-221.259	-357.2308	108	25	8	10664	10	49	43
D-I	0.0	-4.0845	-32.0003	-36.0847	25	1	1	1539	0	8	7
D-K	-48.5637	-13.6306	-237.353	-299.5473	108	44	11	12775	5	38	26
D-L	-48.454	-19.7581	-437.154	-505.3661	154	56	18	22930	5	47	45
D-M	-24.6233	-35.6929	-141.386	-201.7022	58	13	9	5882	7	22	15
E-H	-60.9831	5.9208	-485.08	-540.1423	199	67	23	24840	7	59	52
F-G	-7.506	-23.6044	-28.5766	-59.687	21	0	0	1502	1	5	5
G-H	-4.4727	-14.6583	-104.802	-123.933	55	16	1	4896	1	10	8
I-L	0.0	0.0	-32.4488	-32.4488	28	3	0	1798	0	5	5
K-M	-4.2315	0.0	-8.9915	-13.223	11	2	0	559	0	1	1
L-M	0.0	8.79	-1.8437	6.9463	5	0	0	231	0	3	2

Interface residues

• B-C: ALA1016C, ALA1024C, ALA1068B, ALA1069B, ALA1083C, ALA1105C, ALA1107C, ALA1140C, ALA1143C, ALA1144C, ALA1149B, ALA1154C, ALA1157C, ALA1173C, ALA1199C, ALA1200C, ALA1209C, ALA1412B, ALA1414B, ALA1416B, ALA1434B, ALA1440B, ALA266C, ALA29B, ALA301B, ALA327B, ALA349B, ALA371B, ALA457B, ALA472C, ALA480B, ALA499B, ALA506B, ALA509C, ALA525C, ALA532C, ALA671B, ALA684B, ALA695C, ALA704C, ALA726C, ALA735C, ALA749B, ALA753C, ALA759B, ALA763B, ALA776B, ALA817B, ALA826C, ALA828B, ALA828C, ALA832B, ALA844B, ALA937C, ALA981C, ALA9B, ARG1020C, ARG1067C, ARG1106C, ARG1108C, ARG1116C, ARG1122C, ARG1129C, ARG1135C, ARG1150C, ARG1159C, ARG1215C, ARG1220C, ARG1222C, ARG12B, ARG1422B, ARG247B, ARG261C, ARG267C, ARG28B, ARG320B, ARG326B, ARG328B, ARG335B, ARG337B, ARG344B, ARG350B, ARG412B, ARG446B, ARG469B, ARG47B, ARG498B, ARG512C, ARG57B, ARG617C, ARG620C, ARG635C, ARG63B, ARG677B, ARG728C, ARG730C, ARG766C, ARG782B, ARG806B, ARG821B, ARG839B, ARG840B, ARG884C, ARG935C, ASN1013C, ASN1074C, ASN1110B, ASN1176C, ASN1178C, ASN1211C, ASN1265B, ASN1393B, ASN1427B, ASN253B, ASN339B, ASN358B, ASN445B, ASN471B, ASN488B, ASN516C, ASN538C, ASN548B, ASN654B, ASN660B, ASN741B, ASN742B, ASN757B, ASN75B, ASN762C, ASN767C, ASN802B, ASN834C, ASP1100C, ASP1101C, ASP1125C, ASP1136C, ASP1156C, ASP1186C, ASP1190C, ASP1219C, ASP1223C, ASP1419B, ASP1420B, ASP260B, ASP261B, ASP305B, ASP346B, ASP356B, ASP394C, ASP397C, ASP399C, ASP414B, ASP481B, ASP483B, ASP485B, ASP526B, ASP538B, ASP544B, ASP618C, ASP668B, ASP672B, ASP694C, ASP724C, ASP760C, ASP781B, ASP790B, ASP826B, ASP837C, ASP847B, ASP936C, ASP978C, ASP998C, CYS1029C, CYS1137C, CYS1163C, CYS1166C, CYS1182C, CYS1185C, CYS1400B, CYS1421B, CYS238B, CYS505B, CYS523C, CYS529B, CYS533C, CYS67B, CYS70B, CYS764B, CYS77B, CYS829C, GLN1065C, GLN1070B, GLN1084C, GLN1112C, GLN1117C, GLN1179C, GLN1193C, GLN1205C, GLN1432B, GLN18B, GLN256B, GLN313B, GLN316B, GLN447B, GLN469C, GLN493B, GLN4B, GLN510B, GLN513C, GLN525B, GLN531C, GLN545B, GLN5B, GLN650B, GLN68B, GLN706C, GLN71B, GLN745B, GLN760B, GLN763C, GLN768B, GLN811B, GLN835C, GLN838B, GLN843C, GLN975C, GLN986C, GLU1028C, GLU1053C, GLU1062B, GLU1070C, GLU1120C, GLU1132C, GLU1134C, GLU1149C, GLU1151B, GLU1153C, GLU1206C, GLU1264B, GLU1269B, GLU1407B, GLU1411B, GLU1417B, GLU1426B, GLU16B, GLU254B, GLU25B, GLU262C, GLU26B, GLU312C, GLU319C, GLU333B, GLU433B, GLU486B, GLU495B, GLU496B, GLU500B, GLU526C, GLU529C, GLU542B, GLU621C, GLU681B, GLU696C, GLU697C, GLU698C, GLU699C, GLU72B, GLU742C, GLU76B, GLU771B, GLU795B, GLU801B, GLU812B, GLU822B, GLU833B, GLU836C, GLU846B, GLU872C, GLY1061B, GLY1065B, GLY1068C, GLY1075C, GLY1078C, GLY1109C, GLY1121C, GLY1126C, GLY1127C, GLY1131C, GLY1142C, GLY1164C, GLY1167C, GLY1184C, GLY1395B, GLY1413B, GLY1431B, GLY1437B, GLY1439B, GLY20B, GLY263C, GLY319B, GLY334B, GLY338B, GLY342B, GLY355B, GLY3B, GLY402C, GLY484B, GLY520C, GLY530B, GLY530C, GLY534C, GLY59B, GLY661B, GLY665B, GLY667B, GLY673B, GLY73B, GLY750B, GLY750C, GLY753B, GLY778B, GLY79B, GLY807B, GLY819B, GLY820B, GLY823B, GLY82B, GLY832C, GLY835B, GLY861B, GLY94B, GLY977C, GLY985C, GLY988C, GLY991C, HIS1015C, HIS1025C, HIS1076C, HIS1097C, HIS1104C, HIS1141C, HIS1161C, HIS1177C, HIS1195C, HIS1258B, HIS400C, HIS451B, HIS490B, HIS515C, HIS518C, HIS659B, HIS734C, HIS740C, HIS744C, HIS761C, HIS786B, HIS80B, HIS816B, HIS887C, HIS92B, ILE1011C, ILE1012C, ILE1017C, ILE1027C, ILE1050C, ILE1055C, ILE1085C, ILE1103C, ILE1139C, ILE1152B, ILE1162C, ILE1165C, ILE1172C, ILE1189C, ILE1191C, ILE1194C, ILE1196C, ILE1212C, ILE1408B, ILE1429B, ILE1436B, ILE235B, ILE250B, ILE30B, ILE325B, ILE336B, ILE353B, ILE370B, ILE406B, ILE436B, ILE463B, ILE523B, ILE541B, ILE619C, ILE666B, ILE670B, ILE679B, ILE683B, ILE693C, ILE701C, ILE703C, ILE729C, ILE748C, ILE756B, ILE756C, ILE758B, ILE775B, ILE825B, ILE827C, ILE840C, ILE848B, ILE918C, ILE976C, ILE990C, ILE992C, LEU1026C, LEU1030C, LEU1031C, LEU1059C, LEU1067B, LEU1081C, LEU1095C, LEU1114C, LEU1128C, LEU1147C, LEU1151C, LEU1168C, LEU1175C, LEU11B, LEU1202C, LEU1203C, LEU1207C, LEU1216C, LEU1268B, LEU1397B, LEU1409B, LEU1418B, LEU1430B, LEU21B, LEU236B, LEU239B, LEU262B, LEU266B, LEU315B, LEU329B, LEU340B, LEU359B, LEU374B, LEU443B, LEU450B, LEU470B, LEU472B, LEU489B, LEU501B, LEU504B, LEU508C, LEU509B, LEU514C, LEU521C, LEU528B, LEU535C, LEU58B, LEU637C, LEU657B, LEU658B, LEU65B, LEU702C, LEU710C, LEU740B, LEU749C, LEU784B, LEU805B, LEU808B, LEU824B, LEU845B, LEU860B, LEU86B, LYS1079C, LYS1080C, LYS1102C, LYS1112B, LYS1144B, LYS1148C, LYS1174C, LYS1183C, LYS1201C, LYS1261B, LYS1262B, LYS15B, LYS315C, LYS317B, LYS323B, LYS330B, LYS332B, LYS343B, LYS372B, LYS393C, LYS403B, LYS403C, LYS431B, LYS452B, LYS470C, LYS471C, LYS507C, LYS510C, LYS533B, LYS537C, LYS687B, LYS727C, LYS744B, LYS752B, LYS789B, LYS830B, LYS843B, LYS934C, LYS979C, LYS987C, MET1021C, MET1063B, MET1072C, MET1082C, MET1098C, MET1111C, MET1133C, MET1138C, MET1152C, MET1169C, MET1208C, MET1210C, MET1398B, MET1433B, MET234B, MET304B, MET341B, MET453B, MET455B, MET456B, MET473C, MET487B, MET676B, MET705C, MET746B, MET747C, MET74B, MET761B, MET773C, MET818B, MET839C, MET849B, MET999C, PHE1047C, PHE1069C, PHE1086C, PHE1087C, PHE1130C, PHE1146C, PHE1158C, PHE1180C, PHE1204C, PHE1224C, PHE1402B, PHE1410B, PHE19B, PHE228B, PHE22B, PHE252B, PHE347B, PHE401C, PHE444B, PHE468B, PHE482B, PHE540B, PHE655B, PHE662B, PHE738C, PHE758C, PHE777B, PHE779B, PHE787B, PHE813B, PHE814B, PHE815B, PHE81B, PHE95B, PHE980C, PRO1000C, PRO1014C, PRO1018C, PRO1046C, PRO10B, PRO1110C, PRO1118C, PRO1197C, PRO1214C, PRO1435B, PRO231C, PRO240B, PRO242B, PRO243B, PRO244B, PRO245B, PRO248B, PRO24B, PRO316C, PRO321B, PRO357B, PRO367B, PRO377B, PRO448B, PRO464B, PRO492B, PRO511C, PRO514B, PRO524C, PRO528C, PRO725C, PRO745C, PRO759C, PRO765C, PRO785B, PRO78B, PRO794B, PRO810B, PRO917C, PRO974C, SER1019C, SER1056C, SER1066C, SER1145C, SER1150B, SER1155C, SER1221C, SER1401B, SER1415B, SER1425B, SER229B, SER23B, SER249B, SER251B, SER255B, SER264C, SER265C, SER318B, SER31B, SER324B, SER348B, SER354B, SER369B, SER449B, SER454B, SER466B, SER473B, SER476B, SER494B, SER540C, SER663B, SER700C, SER732C, SER746C, SER751B, SER754B, SER762B, SER764C, SER788B, SER793B, SER796B, SER7B, SER803B, SER831C, SER838C, SER8B, SER919C, SER933C, THR1022C, THR1048C, THR1051C, THR1077C, THR1115C, THR1170C, THR1213C, THR1218C, THR1266B, THR13B, THR1405B, THR1438B, THR237B, THR302B, THR351B, THR373B, THR375B, THR467B, THR475B, THR497B, THR517C, THR527B, THR527C, THR539B, THR664B, THR669B, THR680B, THR69B, THR736C, THR737C, THR739C, THR768C, THR783B, THR809B, THR827B, THR831B, THR882C, THR916C, THR989C, THR993C, TRP233B, TRP308C, TRP519C, TRP552B, TRP656B, TYR1073C, TYR1192C, TYR1198C, TYR1217C, TYR303B, TYR376B, TYR404B, TYR417B, TYR465B, TYR478B, TYR6B, TYR769C, TYR804B, TYR830C, TYR833C, TYR836B, TYR866C, TYR994C, VAL1023C, VAL1052C, VAL1064B, VAL1066B, VAL1099C, VAL1113C, VAL1119C, VAL1160C, VAL1171C, VAL1406B, VAL1424B, VAL1428B, VAL14B, VAL17B, VAL227B, VAL241B, VAL246B, VAL27B, VAL2B, VAL300B, VAL32B, VAL345B, VAL352B, VAL366B, VAL442B, VAL491B, VAL507B, VAL522C, VAL524B, VAL536C, VAL653B, VAL731C, VAL743B, VAL747B, VAL765B, VAL770B, VAL780B, VAL800B, VAL825C, VAL829B, VAL842B, VAL93B
• B-D: ALA223D, ALA671B, ASN660B, ASN741B, ASN742B, ASP190D, ASP196D, ASP220D, ASP538B, ASP668B, ASP672B, ASP739B, GLN195D, GLN224D, GLN745B, GLU194D, GLU200D, GLU542B, GLY665B, GLY667B, GLY673B, HIS188D, ILE666B, ILE670B, LEU186D, LEU571B, LEU737B, LEU740B, LYS222D, LYS533B, LYS567B, LYS569B, LYS738B, PHE219D, PRO568B, PRO570B, PRO674B, THR189D, THR664B, THR669B, THR675B, TRP192D, TYR191D, TYR193D, TYR221D, VAL743B
• B-E: ALA9B, ARG12B, ARG12E, ARG13E, ARG14E, ARG230B, ASN225B, GLN18B, GLU226B, GLU26B, GLY20B, ILE30B, LEU15E, LEU21B, LYS16E, LYS76E, MET1454B, PHE228B, PHE22B, PRO10B, PRO1455B, SER23B, SER4E, SER6E, TRP233B, VAL227B
• B-F: ALA1010B, ALA1014B, ALA1137B, ALA127B, ALA1343B, ALA1346B, ALA1347B, ALA1369B, ALA138F, ALA139F, ALA15F, ALA181F, ALA185F, ALA209F, ARG1012B, ARG11F, ARG1215B, ARG1289B, ARG1326B, ARG1345B, ARG1366B, ARG1391B, ARG1422B, ARG14F, ARG162F, ARG167F, ARG169F, ARG177F, ARG180F, ARG192F, ARG200F, ARG207F, ARG212F, ARG7F, ARG857B, ASN1004B, ASN1009B, ASN1364B, ASN1393B, ASN143F, ASN854B, ASN858B, ASN862B, ASP1013B, ASP1323B, ASP1334B, ASP1373B, ASP159F, ASP182F, ASP853B, ASP871B, CYS1019B, CYS1020B, GLN1008B, GLN1011B, GLN1218B, GLN124B, GLN1378B, GLN174F, GLN179F, GLN865B, GLU1005B, GLU1121B, GLU1315B, GLU1337B, GLU1342B, GLU137F, GLU148F, GLU160F, GLU163F, GLU203F, GLU4F, GLU870B, GLU945B, GLY1002B, GLY1321B, GLY1340B, GLY1344B, GLY1379B, GLY1380B, GLY206F, GLY861B, GLY869B, GLY872B, HIS146F, HIS147F, HIS153F, HIS851B, ILE1006B, ILE1007B, ILE128B, ILE1322B, ILE1327B, ILE1335B, ILE1341B, ILE144F, ILE178F, ILE198F, ILE199F, ILE213F, ILE864B, ILE867B, ILE878B, LEU1000B, LEU1017B, LEU121B, LEU1313B, LEU1339B, LEU1348B, LEU1381B, LEU140F, LEU149F, LEU156F, LEU164F, LEU165F, LEU170F, LEU175F, LEU860B, LEU883B, LEU943B, LEU956B, LYS1003B, LYS122F, LYS129B, LYS133B, LYS1350B, LYS152F, LYS161F, LYS166F, LYS171F, LYS197F, LYS201F, LYS938B, LYS941B, MET1317B, MET1336B, MET1368B, MET1375B, MET215F, MET873B, PHE1018B, PHE866B, PHE942B, PHE947B, PRO1320B, PRO1324B, PRO151F, PRO176F, PRO183F, PRO955B, PRO957B, SER10F, SER1314B, SER1392B, SER173F, SER202F, SER205F, SER210F, SER859B, THR1016B, THR1117B, THR1318B, THR1325B, THR1329B, THR1376B, THR1377B, THR145F, THR204F, THR855B, THR856B, TRP954B, TYR1119B, TYR1328B, TYR1349B, TYR1353B, TYR1362B, TYR1365B, TYR168F, TYR208F, TYR211F, TYR868B, VAL1015B, VAL1118B, VAL1319B, VAL1338B, VAL1363B, VAL1372B, VAL141F, VAL142F, VAL150F, VAL184F, VAL195F, VAL196F, VAL863B, VAL946B, VAL948B, VAL999B
• B-G: ALA1051B, ALA105G, ALA121G, ALA1434B, ALA1440B, ALA499B, ALA80G, ALA875B, ALA876B, ALA91G, ALA98G, ARG1001B, ARG1055B, ARG119G, ARG135G, ARG136G, ARG1422B, ARG387B, ARG498B, ARG635B, ARG79G, ARG857B, ARG90G, ARG92G, ARG97G, ASN1004B, ASN104G, ASN384B, ASN854B, ASN858B, ASN862B, ASN996B, ASP110G, ASP116G, ASP140G, ASP1442B, ASP1446B, ASP145G, ASP154G, ASP77G, ASP853B, ASP874B, CYS505B, GLN100G, GLN1052B, GLN427B, GLN493B, GLN503B, GLN510B, GLN78G, GLU1050B, GLU1062B, GLU114G, GLU124G, GLU127G, GLU1447B, GLU1448B, GLU144G, GLU149G, GLU150G, GLU378B, GLU495B, GLU496B, GLU500B, GLU89G, GLY1002B, GLY1061B, GLY113G, GLY141G, GLY1437B, GLY1439B, GLY429B, GLY861B, GLY95G, HIS1059B, HIS851B, HIS877B, ILE1007B, ILE101G, ILE120G, ILE130G, ILE134G, ILE1436B, ILE1445B, ILE152G, ILE385B, ILE93G, LEU1000B, LEU1054B, LEU1067B, LEU111G, LEU118G, LEU132G, LEU138G, LEU1450B, LEU151G, LEU155G, LEU501B, LEU504B, LEU509B, LEU860B, LEU94G, LEU998B, LEU99G, LYS1003B, LYS128G, LYS129G, LYS1452B, LYS431B, LYS452B, LYS76G, LYS87G, MET103G, MET1063B, MET122G, MET1433B, MET1444B, MET1454B, MET849B, MET85G, PHE1053B, PHE108G, PHE143G, PHE1441B, PRO1060B, PRO106G, PRO117G, PRO131G, PRO139G, PRO1435B, PRO1455B, PRO377B, PRO382B, PRO441B, PRO514B, PRO639B, PRO83G, SER102G, SER142G, SER1449B, SER147G, SER494B, SER502B, THR115G, THR1438B, THR381B, THR497B, THR81G, THR82G, THR855B, THR86G, THR96G, TRP146G, TRP430B, TYR137G, TYR1453B, TYR376B, TYR383B, TYR428B, TYR84G, TYR852B, TYR88G, VAL1057B, VAL1058B, VAL1064B, VAL107G, VAL109G, VAL133G, VAL1443B, VAL1451B, VAL148G, VAL153G, VAL379B, VAL380B, VAL850B, VAL863B, VAL999B
• B-H: ALA68H, ARG12B, ARG21H, ARG58H, ARG60H, ASN10H, ASN71H, ASP1442B, ASP1446B, ASP65H, GLN1432B, GLN24H, GLN57H, GLU1447B, GLU1448B, GLU495B, GLU496B, GLU69H, GLY1439B, GLY19H, GLY429B, GLY59H, GLY66H, HIS14H, ILE1445B, ILE56H, ILE61H, LEU11B, LEU13H, LEU1450B, LEU26H, LEU62H, LYS1452B, LYS15B, LYS23H, LYS27H, LYS431B, MET1433B, MET1444B, MET1454B, MET22H, PHE1441B, PHE17H, PHE18H, PHE70H, PRO10B, PRO15H, PRO20H, PRO63H, SER1449B, SER16H, SER494B, SER67H, THR12H, THR13B, THR1438B, THR497B, THR64H, TYR1453B, VAL1443B, VAL1451B, VAL2B, VAL379B
• B-I: ALA101I, ALA113I, ALA564B, ARG124I, ARG19I, ARG25I, ARG532B, ARG537B, ARG77I, ARG80I, ASN131I, ASN139I, ASN21I, ASN43I, ASN603B, ASN736B, ASN741B, ASP16I, ASP41I, ASP538B, ASP557B, ASP602B, ASP609B, ASP739B, ASP91I, ASP94I, ASP974B, CYS24I, GLN576B, GLN589B, GLN611B, GLU105I, GLU138I, GLU27I, GLU45I, GLU542B, GLY119I, GLY120I, GLY18I, GLY558B, GLY574B, GLY594B, GLY615B, GLY99I, HIS972B, HIS975B, ILE112I, ILE144I, ILE26I, ILE42I, ILE560B, ILE565B, ILE566B, ILE577B, ILE608B, ILE612B, ILE613B, ILE973B, LEU121I, LEU122I, LEU125I, LEU142I, LEU143I, LEU38I, LEU40I, LEU46I, LEU536B, LEU543B, LEU547B, LEU550B, LEU571B, LEU597B, LEU598B, LEU606B, LEU63I, LEU737B, LEU740B, LYS103I, LYS136I, LYS22I, LYS567B, LYS569B, LYS575B, LYS601B, LYS738B, LYS744B, LYS977B, MET123I, MET748B, MET97I, PHE104I, PHE118I, PHE47I, PHE540B, PHE591B, PHE614B, PRO48I, PRO561B, PRO563B, PRO568B, PRO570B, PRO600B, PRO81I, PRO82I, SER117I, SER573B, SER579B, SER599B, SER78I, THR100I, THR39I, THR535B, THR539B, THR562B, THR595B, THR596B, THR76I, THR976B, TRP556B, TRP572B, TRP79I, TYR102I, TYR115I, TYR116I, TYR141I, TYR20I, TYR93I, TYR95I, TYR98I, VAL114I, VAL23I, VAL44I, VAL49I, VAL546B, VAL559B, VAL616B, VAL735B, VAL96I
• B-J: ALA1149B, ALA1200B, ALA1201B, ALA1254B, ALA38J, ALA697B, ALA699B, ALA704B, ARG118J, ARG1194B, ARG1199B, ARG1281B, ARG17J, ARG24J, ARG30J, ARG45J, ARG70J, ARG711B, ARG73J, ARG782B, ARG91J, ARG92J, ASN116J, ASN1265B, ASN22J, ASN23J, ASN51J, ASN700B, ASP113J, ASP1155B, ASP1157B, ASP1198B, ASP1257B, ASP19J, ASP65J, ASP781B, ASP790B, ASP791B, ASP94J, GLN114J, GLN698B, GLN87J, GLN89J, GLN90J, GLU1151B, GLU1196B, GLU1255B, GLU1256B, GLU1264B, GLU1269B, GLU18J, GLU47J, GLU696B, GLU712B, GLU715B, HIS1258B, HIS46J, ILE1148B, ILE1152B, ILE1163B, ILE49J, LEU1143B, LEU1192B, LEU1193B, LEU1195B, LEU1197B, LEU1260B, LEU1268B, LEU25J, LEU26J, LEU42J, LEU48J, LEU68J, LEU701B, LEU702B, LEU710B, LEU99J, LYS1144B, LYS115J, LYS1235B, LYS1261B, LYS20J, LYS695B, LYS789B, LYS93J, MET708B, MET97J, PHE100J, PHE101J, PHE27J, PHE714B, PHE777B, PHE779B, PHE787B, PHE85J, PHE86J, PRO1156B, PRO1158B, PRO1164B, PRO1190B, PRO16J, PRO41J, PRO66J, PRO69J, PRO785B, SER112J, SER1145B, SER1150B, SER1189B, SER40J, SER713B, SER788B, SER88J, SER96J, THR111J, THR1147B, THR1161B, THR2J, THR50J, THR67J, THR694B, THR703B, THR709B, THR95J, TRP1191B, TYR1153B, TYR1154B, TYR15J, TYR44J, TYR792B, VAL1146B, VAL1162B, VAL43J, VAL693B, VAL718B, VAL780B, VAL84J, VAL98J
• B-L: ALA27L, ALA30L, ALA371B, ALA3L, ALA48L, ALA59L, ALA60L, ARG469B, ARG47L, ARG6L, ARG74L, ASN2L, ASN358B, ASN44L, ASN548B, ASP22L, ASP24L, ASP356B, ASP544B, ASP555B, ASP557B, ASP5L, GLN545B, GLN76L, GLU542B, GLU64L, GLU8L, GLY355B, GLY365B, GLY558B, HIS40L, HIS659B, HIS65L, ILE33L, ILE370B, ILE463B, ILE560B, ILE75L, LEU359B, LEU51L, LEU543B, LEU547B, LEU550B, LEU57L, LEU658B, LEU73L, LEU9L, LYS26L, LYS368B, LYS372B, LYS461B, LYS62L, LYS644B, LYS651B, LYS72L, MET1L, MET549B, PHE58L, PHE655B, PHE67L, PHE68L, PHE71L, PRO28L, PRO357B, PRO367B, PRO464B, PRO4L, PRO554B, PRO66L, SER354B, SER369B, SER466B, THR25L, THR34L, THR351B, THR467B, TRP552B, TRP556B, TYR465B, TYR551B, TYR61L, VAL31L, VAL32L, VAL366B, VAL462B, VAL546B, VAL553B, VAL559B, VAL56L, VAL63L
• C-D: ALA1003C, ALA1083C, ALA164D, ALA168D, ALA173D, ALA174D, ALA175D, ALA198D, ALA225D, ALA28D, ALA30D, ALA39D, ALA59D, ALA64D, ARG1060C, ARG1067C, ARG148D, ARG34D, ARG35D, ARG66D, ARG848C, ARG852C, ARG904C, ARG969C, ARG995C, ARG996C, ASN1074C, ASN184D, ASN206D, ASN231D, ASN31D, ASN54D, ASN784C, ASN786C, ASN842C, ASP181D, ASP190D, ASP60D, ASP847C, ASP950C, ASP998C, GLN1065C, GLN1084C, GLN151D, GLN195D, GLN203D, GLN843C, GLU1004C, GLU1053C, GLU1070C, GLU166D, GLU177D, GLU179D, GLU194D, GLU200D, GLU233D, GLU40D, GLU52D, GLU61D, GLU997C, GLY1005C, GLY1063C, GLY1068C, GLY1075C, GLY1078C, GLY171D, GLY849C, GLY902C, GLY947C, HIS1062C, HIS1076C, HIS167D, HIS188D, HIS65D, ILE1006C, ILE1085C, ILE163D, ILE176D, ILE38D, ILE63D, ILE795C, ILE846C, ILE948C, ILE973C, LEU1059C, LEU1081C, LEU186D, LEU27D, LEU58D, LEU67D, LEU69D, LEU796C, LEU850C, LEU854C, LYS1033C, LYS1079C, LYS1080C, LYS149D, LYS165D, LYS169D, LYS185D, LYS187D, LYS191C, LYS199D, LYS972C, MET1072C, MET1082C, MET230D, MET29D, MET37D, MET999C, PHE1001C, PHE1069C, PHE1086C, PHE1087C, PHE178D, PHE219D, PHE228D, PHE62D, PHE855C, PHE856C, PRO1000C, PRO1008C, PRO172D, PRO182D, PRO202D, PRO799C, PRO901C, SER1056C, SER1066C, SER187C, SER197D, SER204D, SER32D, SER844C, SER845C, SER853C, THR1002C, THR1077C, THR189D, THR55D, THR56D, THR783C, THR970C, THR971C, TRP170D, TRP183D, TRP192D, TRP201D, TYR1064C, TYR1073C, TYR180D, TYR190C, TYR191D, TYR193D, TYR229D, TYR785C, TYR797C, TYR798C, TYR830C, TYR994C, VAL1007C, VAL1071C, VAL235D, VAL36D, VAL49D, VAL51D, VAL57D, VAL787C, VAL949C
• C-E: ARG1215C, ARG1220C, ARG1222C, ARG12E, ARG13E, ARG14E, ASN1187C, ASP1186C, ASP1190C, ASP1219C, CYS1163C, CYS1166C, CYS1185C, GLU20E, GLY1164C, GLY1167C, GLY1184C, ILE1165C, ILE1189C, ILE1191C, LEU1168C, LEU15E, LYS16E, LYS17E, SER1221C, SER4E, SER6E, THR10E, THR1213C, THR5E, TYR1192C, TYR1217C, VAL18E
• C-F: ARG1222C, ASP1223C, GLN174F, GLU172F, LEU170F, LYS171F, PHE1224C, SER173F
• C-G: ALA1140C, ALA1143C, ALA1144C, ALA91G, ARG1220C, ARG92G, ASP1223C, ASP140G, GLY1142C, GLY141G, GLY95G, HIS1141C, ILE1139C, LEU138G, LEU99G, LYS72G, LYS87G, MET1138C, PHE1224C, PRO139G, SER1145C, SER142G, THR96G, TYR88G
• C-H: ALA1144C, ASN10H, ASN1178C, ASN1187C, ASP1190C, ASP65H, GLN1179C, GLN153H, GLU1149C, GLU1153C, GLY40H, HIS1195C, ILE1165C, ILE1189C, LEU62H, LYS1148C, LYS1188C, LYS41H, MET1152C, PHE42H, PRO63H, SER1145C, SER152H, THR39H, THR64H, TYR1192C, VAL154H
• C-I: LYS22I, MET1082C
• C-J: ALA56J, ALA577C, ALA594C, ALA735C, ARG267C, ARG287C, ARG30J, ARG392C, ARG45J, ARG591C, ARG595C, ARG5J, ARG601C, ARG617C, ARG620C, ARG70J, ARG91J, ARG92J, ASN11J, ASN12J, ASN306C, ASN51J, ASN592C, ASP294C, ASP307C, ASP320C, ASP391C, ASP394C, ASP576C, ASP618C, ASP61J, ASP65J, ASP94J, ASP9J, CYS10J, CYS29J, CYS302C, CYS388C, CYS7J, GLN309C, GLN325C, GLN395C, GLN60J, GLN87J, GLN89J, GLN90J, GLU262C, GLU296C, GLU299C, GLU312C, GLU319C, GLU47J, GLU54J, GLU621C, GLU623C, GLU697C, GLU698C, GLU699C, GLY263C, GLY295C, GLY53J, GLY57J, GLY63J, HIS46J, HIS572C, HIS734C, HIS740C, ILE292C, ILE297C, ILE324C, ILE49J, ILE52J, ILE619C, ILE62J, ILE701C, ILE703C, LEU14J, LEU298C, LEU311C, LEU314C, LEU387C, LEU390C, LEU42J, LEU48J, LEU68J, LEU702C, LYS227C, LYS315C, LYS393C, LYS622C, LYS649C, LYS93J, MET13J, MET310C, MET313C, MET597C, PHE100J, PHE27J, PHE322C, PHE4J, PHE6J, PHE738C, PHE85J, PHE86J, PRO16J, PRO293C, PRO316C, PRO575C, PRO593C, PRO66J, PRO69J, SER64J, SER700C, SER88J, THR2J, THR31J, THR3J, THR50J, THR55J, THR578C, THR67J, THR736C, THR737C, THR739C, THR95J, TRP308C, TYR15J, TYR44J, VAL102J, VAL305C, VAL318C, VAL43J, VAL58J, VAL59J, VAL84J
• C-K: ALA1003C, ALA1035C, ALA1036C, ALA35K, ALA823C, ARG43K, ARG47K, ARG48K, ARG62K, ARG6K, ARG788C, ARG815C, ARG848C, ARG852C, ARG996C, ASN1040C, ASN64K, ASN784C, ASN786C, ASN822C, ASN842C, ASP1009C, ASP188C, ASP198C, ASP31K, ASP55K, ASP847C, CYS1029C, CYS10K, CYS195C, CYS45K, CYS46K, CYS7K, GLN115C, GLN800C, GLN821C, GLN951C, GLU1004C, GLU1041C, GLU1070C, GLU186C, GLU194C, GLU32K, GLU58K, GLU816C, GLY1005C, GLY1039C, GLY1042C, GLY1068C, GLY1088C, GLY11K, GLY33K, GLY779C, GLY804C, GLY820C, GLY849C, HIS1062C, HIS53K, ILE1006C, ILE2K, ILE50K, ILE57K, ILE795C, ILE824C, ILE846C, LEU1010C, LEU1037C, LEU1059C, LEU189C, LEU192C, LEU36K, LEU41K, LEU51K, LEU56K, LEU61K, LEU782C, LEU796C, LEU803C, LEU817C, LEU850C, LEU854C, LYS1033C, LYS12K, LYS191C, LYS193C, LYS42K, LYS59K, LYS801C, LYS813C, MET1072C, MET1K, MET49K, PHE1069C, PHE1087C, PHE197C, PHE60K, PHE781C, PHE814C, PHE851C, PHE8K, PRO1008C, PRO1089C, PRO196C, PRO4K, PRO65K, PRO799C, PRO802C, PRO818C, SER1032C, SER1038C, SER187C, SER37K, SER844C, SER845C, SER9K, THR1002C, THR1090C, THR185C, THR34K, THR52K, THR783C, TRP18K, TYR1064C, TYR1091C, TYR190C, TYR21K, TYR44K, TYR63K, TYR785C, TYR797C, TYR798C, VAL1007C, VAL1034C, VAL3K, VAL54K, VAL5K, VAL780C, VAL787C, VAL825C
• C-L: ALA3L, ALA48L, ALA69L, ARG1122C, ARG47L, ARG6L, ARG848C, ARG852C, ARG995C, ASN1074C, ASN2L, ASN44L, ASN946C, ASP1100C, ASP1101C, ASP39L, ASP847C, ASP998C, GLN843C, GLN975C, GLU64L, GLU997C, GLY1075C, GLY1078C, GLY832C, GLY991C, HIS1076C, HIS40L, HIS65L, ILE1103C, ILE846C, ILE973C, ILE976C, ILE990C, ILE992C, LEU45L, LEU9L, LYS1079C, LYS62L, MET1L, PHE10L, PHE67L, PHE68L, PRO4L, PRO66L, SER831C, SER844C, SER845C, THR1077C, THR41L, THR944C, THR993C, TYR61L, TYR833C, TYR994C, VAL1099C, VAL63L
• C-M: ALA111C, ALA32M, ALA45M, ALA59M, ALA69M, ALA900C, ARG120C, ARG42M, ARG47M, ARG54M, ARG60M, ARG63M, ARG70M, ARG848C, ARG852C, ARG904C, ARG967C, ARG969C, ASN103C, ASN786C, ASN957C, ASP106C, ASP44M, ASP847C, ASP891C, ASP894C, ASP895C, ASP896C, ASP950C, CYS31M, CYS34M, GLN115C, GLN66M, GLN843C, GLN951C, GLN958C, GLU104C, GLU116C, GLU33M, GLU68M, GLU863C, GLU875C, GLY107C, GLY52M, GLY849C, GLY897C, GLY902C, GLY947C, GLY960C, HIS110C, HIS53M, ILE30M, ILE55M, ILE846C, ILE899C, ILE948C, ILE973C, LEU112C, LEU119C, LEU122C, LEU192C, LEU40M, LEU56M, LEU57M, LEU64M, LEU893C, LEU898C, LEU953C, LEU961C, LYS191C, LYS193C, LYS28M, LYS58M, LYS62M, LYS892C, LYS962C, LYS965C, MET789C, PHE67M, PHE874C, PHE963C, PRO901C, SER105C, SER35M, SER41M, THR109C, THR43M, THR61M, THR873C, THR955C, THR956C, THR970C, THR971C, TYR113C, TYR29M, TYR797C, TYR890C, VAL102C, VAL108C, VAL46M, VAL65M, VAL787C, VAL903C, VAL949C, VAL952C, VAL954C, VAL964C, VAL966C
• D-I: ARG19I, ASN184D, ASN21I, ASN43I, ASP190D, ASP217D, ASP220D, ASP94I, GLU45I, GLY216D, HIS188D, LEU186D, LEU46I, LYS187D, LYS222D, LYS22I, PHE219D, PHE47I, PRO218D, PRO48I, THR189D, TYR191D, TYR193D, TYR221D, VAL44I
• D-K: ALA164D, ALA168D, ALA173D, ALA174D, ALA175D, ALA45D, ALA59D, ARG148D, ARG43K, ARG62K, ARG66D, ARG6K, ASN112D, ASN140D, ASN17D, ASN231D, ASN23K, ASN64K, ASP136D, ASP16D, ASP16K, ASP19D, ASP28K, ASP55K, CYS10K, CYS145D, CYS45K, CYS46K, CYS7K, GLN135D, GLN151D, GLU138D, GLU177D, GLU19K, GLU233D, GLU58K, GLY11K, GLY139D, GLY141D, GLY150D, GLY15K, GLY171D, GLY236D, GLY40K, GLY68D, HIS53K, HIS65D, ILE133D, ILE134D, ILE144D, ILE176D, ILE2K, ILE38D, ILE57K, ILE63D, ILE70D, LEU143D, LEU147D, LEU22K, LEU24K, LEU39K, LEU41K, LEU44D, LEU56K, LEU58D, LEU61K, LEU67D, LEU69D, LEU72D, LYS12K, LYS137D, LYS146D, LYS149D, LYS169D, LYS17K, LYS205D, LYS42K, LYS59K, MET1K, PHE60K, PHE62D, PHE8K, PRO172D, PRO4K, PRO65K, PRO71D, SER115D, SER20K, SER234D, SER237D, SER9K, THR110D, THR111D, THR43D, THR55D, THR56D, TRP170D, TRP18K, TYR114D, TYR63K, VAL113D, VAL13K, VAL142D, VAL14K, VAL235D, VAL3K, VAL57D, VAL5K
• D-L: ALA100L, ALA13D, ALA164D, ALA168D, ALA256D, ALA261D, ALA28D, ALA30D, ALA39D, ALA48L, ALA69L, ALA86L, ALA90L, ARG11D, ARG246D, ARG34D, ARG35D, ARG47L, ARG6L, ARG84D, ASN104L, ASN110L, ASN17D, ASN24D, ASN31D, ASN44L, ASN52L, ASN89L, ASN92L, ASN96L, ASP16D, ASP19D, ASP241D, ASP249D, ASP266D, ASP268D, ASP26D, ASP39L, ASP5L, ASP85D, ASP85L, CYS91L, GLN112L, GLN224D, GLN242D, GLN252D, GLN264D, GLN7D, GLU106L, GLU108L, GLU12D, GLU166D, GLU36L, GLU38L, GLU3D, GLU40D, GLU49L, GLU4D, GLU78D, GLU8L, GLY162D, GLY247D, GLY43L, GLY5D, GLY99L, HIS167D, HIS40L, ILE10D, ILE163D, ILE21D, ILE21L, ILE248D, ILE258D, ILE33L, ILE38D, ILE46L, ILE75L, ILE94L, ILE95L, LEU101L, LEU111L, LEU114L, LEU11L, LEU12L, LEU19L, LEU22D, LEU251D, LEU259D, LEU260D, LEU262D, LEU27D, LEU33D, LEU42L, LEU45L, LEU73L, LEU87L, LEU98L, LEU9L, LYS102L, LYS15D, LYS161D, LYS165D, LYS169D, LYS18L, LYS20L, LYS253D, LYS254D, LYS37L, LYS84L, LYS88L, LYS97L, LYS9D, MET230D, MET265D, MET29D, MET37D, PHE105L, PHE10L, PHE20D, PHE228D, PHE35L, PHE71L, PHE7L, PRO239D, PRO6D, PRO83L, SER14D, SER17L, SER23D, SER257D, SER32D, SER93L, THR103L, THR107L, THR113L, THR250D, THR263D, THR34L, THR41L, TRP109L, TRP170D, TYR61L, TYR82D, VAL18D, VAL232D, VAL240D, VAL243D, VAL244D, VAL245D, VAL255D, VAL25D, VAL36D, VAL63L, VAL8D
• D-M: ALA159D, ALA168D, ALA45D, ALA59D, ALA59M, ALA64D, ALA69M, ARG60M, ARG63M, ARG66D, ARG70M, ARG84D, ASN54D, ASP47D, ASP60D, ASP90D, CYS157D, CYS34M, GLN66M, GLU166D, GLU33M, GLU50D, GLU52D, GLU61D, GLU68M, GLY162D, GLY68D, HIS167D, HIS65D, ILE163D, ILE30M, ILE46D, ILE63D, LEU155D, LEU27M, LEU64M, LEU67D, LEU69D, LYS149D, LYS154D, LYS160D, LYS161D, LYS165D, LYS169D, LYS62M, PHE62D, PHE67M, SER35M, SER48D, THR156D, THR53D, THR55D, THR61M, TRP170D, VAL158D, VAL49D, VAL51D, VAL65M
• E-H: ALA178E, ALA184E, ALA188E, ALA191E, ALA24E, ALA25E, ALA49E, ALA55E, ALA62E, ALA69E, ALA76H, ARG119E, ARG11E, ARG13E, ARG142H, ARG144H, ARG153E, ARG21H, ARG56E, ARG66E, ARG67E, ARG68E, ARG72E, ARG75H, ASN10H, ASN137E, ASN138E, ASN143E, ASN150E, ASN23E, ASN39E, ASN51E, ASN53H, ASN71H, ASP140E, ASP166H, ASP186E, ASP189E, ASP50H, ASP52H, ASP55H, ASP6H, ASP88H, CYS150H, CYS185E, CYS38H, CYS47H, GLN102H, GLN146E, GLN179E, GLN24H, GLN28E, GLN31E, GLN34E, GLN37E, GLN41E, GLN57H, GLN74E, GLN9E, GLU148H, GLU165H, GLU190E, GLU20E, GLU21E, GLU22E, GLU32E, GLU32H, GLU33H, GLU35H, GLU43E, GLU45E, GLU46E, GLU54E, GLU61E, GLU65E, GLU85H, GLY104H, GLY135E, GLY136E, GLY149H, GLY169H, GLY181E, GLY30E, GLY36H, GLY40H, GLY42E, GLY43H, GLY84H, GLY89H, HIS173E, HIS40E, ILE11H, ILE143H, ILE147H, ILE157H, ILE171H, ILE195E, ILE38E, ILE45H, ILE48E, ILE4H, ILE54H, ILE59E, LEU123E, LEU130E, LEU141E, LEU148E, LEU168H, LEU183E, LEU194E, LEU27E, LEU29E, LEU30H, LEU31H, LEU35E, LEU46H, LEU47E, LEU49H, LEU50E, LEU52E, LEU63E, LEU7H, LEU9H, LYS107H, LYS139E, LYS140H, LYS142E, LYS146H, LYS17E, LYS192E, LYS27H, LYS36E, LYS41H, LYS5H, LYS60E, LYS73H, LYS76E, LYS80H, LYS83H, MET106H, MET145E, MET1H, PHE151E, PHE175E, PHE2H, PHE33E, PHE3H, PHE42H, PHE70E, PHE79H, PHE82H, PHE8E, PRO105H, PRO174E, PRO196E, PRO81H, SER141H, SER152E, SER152H, SER155H, SER156H, SER182E, SER197E, SER37H, SER4E, SER53E, SER6E, SER73E, SER8H, THR133E, THR134E, THR144E, THR149E, THR187E, THR193E, THR26E, THR28H, THR39H, THR5E, THR7E, THR90H, TYR147E, TYR167H, TYR221E, TYR44H, TYR51H, TYR74H, VAL101H, VAL103H, VAL145H, VAL34H, VAL48H, VAL58E, VAL72H, VAL77H, VAL78H, VAL86H, VAL87H, VAL91H
• F-G: ALA73G, ALA80G, ARG167F, ARG169F, ARG79G, ASP140G, GLN174F, GLN78G, GLU144G, GLY141G, ILE74G, LEU138G, LEU170F, LYS171F, LYS72G, PHE143G, PRO139G, PRO75G, SER142G, THR81G, TYR168F
• G-H: ALA105G, ALA68H, ALA98G, ARG135G, ARG21H, ARG58H, ARG60H, ARG79G, ARG92G, ARG97G, ASN104G, ASP145G, ASP65H, GLN100G, GLN57H, GLU144G, GLU150G, GLY19H, GLY59H, GLY66H, GLY95G, HIS14H, ILE101G, ILE130G, ILE134G, ILE61H, ILE74G, ILE93G, LEU132G, LEU13H, LEU62H, LEU99G, LYS76G, MET103G, MET22H, PHE108G, PHE143G, PHE17H, PHE18H, PRO106G, PRO131G, PRO15H, PRO20H, PRO63H, SER102G, SER147G, SER16H, SER67H, THR64H, THR96G, TRP146G, TYR137G, VAL107G, VAL133G, VAL148G
• I-L: ALA27L, ALA59L, ALA84I, ARG54L, ARG74L, ARG77I, ARG80I, ARG87I, ASN29L, ASN52L, ASP53L, ASP86I, GLN76L, GLN83I, GLU79L, GLY85I, LEU51L, LEU57L, LYS55L, PHE58L, PRO28L, PRO81I, PRO82I, SER78I, THR77L, THR78L, TRP79I, VAL56L
• K-M: ALA32M, ASN64K, CYS31M, CYS34M, GLU33M, ILE30M, ILE55M, LEU57M, PRO65K, SER35M, SER36M
• L-M: ARG6L, ARG70M, ASP5L, PHE10L, PHE7L