3H3F

rabbit muscle l-lactate dehydrogenase in complex with nadh and oxamate

• Total interactions analyzed: 28
• Total true interactions: 14
• Strongest Interaction:
  • Chains: E-H
  • Int. Res.: 145
  • Norm. En. per Res.: -3.6927
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-86.499	-40.3732	-721.89	-848.7622	246	17	24	30669	5	69	61
A-C	-37.5483	16.864	-199.536	-220.2203	103	10	19	9635	0	13	27
A-D	-150.2301	-22.6207	-365.343	-538.1938	148	25	9	16541	4	53	64
B-C	-103.54	-8.5135	-365.061	-477.1145	143	17	7	15774	3	49	61
B-D	-40.9987	16.454	-199.627	-224.1717	103	10	18	9775	0	12	26
B-E	0.0	0.0	-1.0421	-1.0421	17	0	0	181	0	3	5
B-F	0.0	-14.1915	-85.6298	-99.8213	56	1	0	3872	0	28	17
C-D	-59.9025	-37.992	-728.01	-825.9045	243	38	24	31302	6	69	63
E-F	-77.0084	-41.3032	-715.83	-834.1417	244	25	26	30491	6	68	61
E-G	-43.0984	15.933	-194.728	-221.8934	103	15	18	9705	0	12	26
E-H	-140.6075	-6.529	-388.303	-535.4395	145	22	9	16328	6	52	63
F-G	-102.3377	-13.2879	-367.453	-483.0785	148	18	9	16374	2	50	61
F-H	-44.2451	16.5514	-201.725	-229.4187	103	12	18	9822	0	13	28
G-H	-85.4388	-42.2576	-701.687	-829.3834	246	36	26	30452	5	69	62

Interface residues

• A-B: ALA167A, ALA167B, ALA181A, ALA181B, ALA1A, ALA1B, ALA206A, ALA206B, ALA237A, ALA237B, ALA250A, ALA250B, ALA256A, ALA256B, ALA29A, ALA29B, ALA2A, ALA2B, ALA33A, ALA33B, ALA35A, ALA35B, ARG168A, ARG168B, ARG170A, ARG170B, ARG176A, ARG176B, ARG268A, ARG268B, ARG72A, ARG72B, ASN163A, ASN163B, ASN204A, ASN204B, ASP165A, ASP165B, ASP222A, ASP222B, ASP235A, ASP235B, ASP257A, ASP257B, ASP42A, ASP42B, ASP55A, ASP55B, ASP5A, ASP5B, ASP63A, ASP63B, CYS162B, CYS184A, CYS184B, CYS34A, CYS34B, GLN232A, GLN232B, GLN65A, GLN65B, GLN6A, GLN6B, GLU14B, GLU175A, GLU175B, GLU216A, GLU216B, GLU224A, GLU224B, GLU239A, GLU239B, GLU260A, GLU260B, GLU54A, GLU54B, GLU60A, GLU60B, GLY174A, GLY174B, GLY178A, GLY178B, GLY207B, GLY218A, GLY218B, GLY245A, GLY245B, GLY252A, GLY252B, GLY28A, GLY28B, GLY31A, GLY31B, GLY59A, GLY59B, GLY67A, GLY67B, HIS180A, HIS180B, HIS185A, HIS185B, HIS214A, HIS214B, HIS270A, HIS270B, HIS66A, HIS66B, ILE241A, ILE241B, ILE251A, ILE251B, ILE36A, ILE36B, ILE38A, ILE38B, ILE76A, ILE76B, ILE8A, ILE8B, LEU164A, LEU164B, LEU172A, LEU172B, LEU177A, LEU177B, LEU182A, LEU182B, LEU210A, LEU210B, LEU213A, LEU213B, LEU217A, LEU217B, LEU243A, LEU243B, LEU253A, LEU253B, LEU258A, LEU258B, LEU39A, LEU39B, LEU3A, LEU3B, LEU43A, LEU43B, LEU49A, LEU57A, LEU57B, LEU64A, LEU64B, LEU69A, LEU69B, LEU71A, LEU71B, LEU7A, LEU7B, LYS211A, LYS211B, LYS223A, LYS223B, LYS242A, LYS242B, LYS244A, LYS244B, LYS41A, LYS41B, LYS4A, LYS4B, LYS56A, LYS56B, LYS58A, LYS58B, LYS75A, LYS75B, MET173A, MET173B, MET203A, MET203B, MET32A, MET32B, MET40A, MET40B, MET53A, MET53B, MET61A, MET61B, MET62A, MET62B, PHE169A, PHE169B, PHE70A, PHE70B, PRO215A, PRO215B, PRO271A, PRO271B, PRO74A, PRO74B, SER166A, SER166B, SER183A, SER183B, SER209A, SER209B, SER236A, SER236B, SER254A, SER254B, SER37A, SER37B, SER68A, SER68B, THR212A, THR212B, THR247A, THR247B, THR248A, THR248B, THR73A, THR73B, TRP226A, TRP226B, TRP249A, TRP249B, TYR171A, TYR171B, TYR238A, TYR246A, TYR246B, VAL179A, VAL179B, VAL205A, VAL205B, VAL208A, VAL208B, VAL233A, VAL233B, VAL240A, VAL240B, VAL255A, VAL255B, VAL27A, VAL27B, VAL30B, VAL77A, VAL77B
• A-C: ALA181A, ALA181C, ALA206A, ALA206C, ARG170A, ARG170C, ARG267A, ARG267C, ARG268A, ARG268C, ARG72A, ARG72C, ASN204A, ASN204C, ASN265A, ASN265C, ASP301A, ASP301C, CYS184A, CYS184C, CYS292A, CYS292C, GLU175A, GLU260A, GLU260C, GLY174A, GLY174C, GLY178A, GLY178C, GLY186A, GLY186C, GLY202A, GLY202C, GLY207A, GLY207C, HIS180A, HIS180C, HIS185A, HIS185C, HIS270A, HIS270C, LEU177A, LEU177C, LEU182A, LEU182C, LEU189A, LEU189C, LEU210C, LEU213A, LEU213C, LEU266A, LEU266C, LEU294A, LEU294C, LEU307A, LEU307C, LYS264A, LYS264C, LYS304A, LYS304C, MET203A, MET203C, PHE70C, PRO271A, PRO271C, PRO291A, PRO291C, SER183A, SER183C, SER201A, SER201C, SER209A, SER209C, SER261A, SER261C, SER300A, SER300C, THR212A, THR212C, THR306A, THR306C, TRP187A, TRP187C, TYR280A, TYR280C, VAL179A, VAL179C, VAL199A, VAL199C, VAL205A, VAL205C, VAL208A, VAL208C, VAL269A, VAL269C, VAL290A, VAL290C, VAL293A, VAL293C, VAL303A, VAL303C, VAL305A, VAL305C
• A-D: ALA1A, ALA1D, ALA2D, ALA44A, ALA44D, ARG156A, ARG156D, ARG267A, ARG267D, ARG268A, ARG268D, ARG72A, ARG72D, ASN10A, ASN10D, ASN155A, ASN155D, ASN20A, ASN20D, ASN265A, ASN265D, ASN297A, ASN297D, ASP257A, ASP257D, ASP301A, ASP301D, ASP42A, ASP42D, ASP45A, ASP45D, ASP5A, ASP5D, CYS292A, CYS292D, GLN19A, GLN19D, GLN296A, GLN296D, GLN6A, GLN6D, GLU14A, GLU14D, GLU15A, GLU15D, GLU260A, GLU260D, GLU46A, GLU46D, GLY278A, GLY278D, GLY295A, GLY295D, GLY298A, GLY298D, HIS129A, HIS16A, HIS16D, HIS270A, HIS270D, HIS9A, HIS9D, ILE262A, ILE262D, ILE299A, ILE299D, ILE8A, ILE8D, LEU11A, LEU11D, LEU12A, LEU12D, LEU182A, LEU182D, LEU266A, LEU266D, LEU276A, LEU276D, LEU279A, LEU279D, LEU3A, LEU3D, LEU43A, LEU43D, LEU71A, LEU71D, LEU7A, LEU7D, LYS131A, LYS131D, LYS13A, LYS13D, LYS154A, LYS154D, LYS264A, LYS264D, LYS277A, LYS277D, LYS304A, LYS304D, LYS41A, LYS41D, LYS4A, LYS4D, LYS75A, LYS75D, LYS89A, LYS89D, MET263A, MET263D, MET275A, MET275D, PRO153A, PRO153D, PRO18A, PRO18D, PRO291A, PRO291D, PRO74A, PRO74D, SER261A, SER261D, SER300A, SER300D, SER68D, THR274A, THR274D, THR306A, THR306D, THR73A, THR73D, TYR280A, TYR280D, VAL157A, VAL17A, VAL17D, VAL269A, VAL269D, VAL290A, VAL290D, VAL293A, VAL293D, VAL302A, VAL302D, VAL303A, VAL303D, VAL305A, VAL305D
• B-C: ALA1B, ALA1C, ALA2C, ALA44B, ALA44C, ARG156B, ARG156C, ARG267B, ARG267C, ARG268B, ARG268C, ARG72B, ARG72C, ASN10B, ASN10C, ASN155B, ASN155C, ASN20B, ASN20C, ASN265B, ASN265C, ASN297B, ASN297C, ASP257B, ASP257C, ASP301B, ASP301C, ASP42B, ASP42C, ASP45B, ASP45C, ASP5B, ASP5C, CYS292B, CYS292C, GLN19B, GLN19C, GLN296B, GLN296C, GLN6B, GLN6C, GLU14B, GLU14C, GLU15B, GLU15C, GLU260B, GLU260C, GLU46B, GLU46C, GLY278B, GLY278C, GLY295B, GLY295C, GLY298B, GLY298C, HIS16B, HIS16C, HIS9B, HIS9C, ILE262B, ILE262C, ILE299B, ILE299C, ILE8B, ILE8C, LEU11B, LEU11C, LEU12B, LEU12C, LEU182B, LEU182C, LEU266B, LEU266C, LEU276B, LEU276C, LEU279B, LEU279C, LEU39B, LEU3C, LEU43B, LEU43C, LEU71B, LEU71C, LEU7B, LEU7C, LYS131B, LYS131C, LYS13B, LYS13C, LYS154B, LYS154C, LYS264B, LYS264C, LYS277B, LYS277C, LYS304B, LYS304C, LYS41B, LYS41C, LYS4B, LYS4C, LYS75B, LYS75C, LYS89B, LYS89C, MET263B, MET263C, MET275B, MET275C, PRO153B, PRO153C, PRO18B, PRO18C, PRO291B, PRO291C, PRO74B, PRO74C, SER261B, SER261C, SER300B, SER300C, THR274B, THR274C, THR306B, THR306C, THR73B, THR73C, TYR280B, TYR280C, VAL17B, VAL17C, VAL269B, VAL269C, VAL290B, VAL290C, VAL293B, VAL293C, VAL302B, VAL302C, VAL303B, VAL303C, VAL305B, VAL305C
• B-D: ALA181B, ALA181D, ALA206B, ALA206D, ARG170B, ARG170D, ARG267B, ARG267D, ARG268B, ARG268D, ARG72B, ARG72D, ASN204B, ASN204D, ASN265B, ASN265D, ASP301B, ASP301D, CYS184B, CYS184D, CYS292B, CYS292D, GLU175B, GLU260B, GLU260D, GLY174B, GLY174D, GLY178B, GLY178D, GLY186B, GLY186D, GLY202B, GLY202D, GLY207B, GLY207D, HIS180B, HIS180D, HIS185B, HIS185D, HIS270B, HIS270D, LEU177B, LEU177D, LEU182B, LEU182D, LEU189B, LEU189D, LEU210B, LEU210D, LEU213B, LEU213D, LEU266B, LEU266D, LEU294B, LEU294D, LEU307B, LEU307D, LYS264B, LYS264D, LYS304B, LYS304D, MET203B, MET203D, PRO271B, PRO271D, PRO291B, PRO291D, SER183B, SER183D, SER201B, SER201D, SER209B, SER209D, SER261B, SER261D, SER300B, SER300D, THR212B, THR212D, THR306B, THR306D, TRP187B, TRP187D, TYR280B, TYR280D, VAL179B, VAL179D, VAL199B, VAL199D, VAL205B, VAL205D, VAL208B, VAL208D, VAL269B, VAL269D, VAL290B, VAL290D, VAL293B, VAL293D, VAL303B, VAL303D, VAL305B, VAL305D
• B-E: ARG111B, ASN114B, GLN100E, GLN110B, GLN330B, GLN99E, GLU101E, GLY245E, ILE115B, ILE241E, LEU243E, LYS117B, LYS242E, LYS244E, PHE118B, PHE331B, TYR238E
• B-F: ALA95F, ALA97B, ALA97F, ARG105B, ARG111B, ARG111F, ARG98B, ARG98F, ASN107B, ASN112F, ASN114B, ASN114F, ASN122F, ASP194B, ASP235B, ASP51F, ASP55F, ASP81F, GLN100B, GLN100F, GLN110B, GLN110F, GLN330F, GLN99B, GLU101B, GLU103B, GLU103F, GLU239B, GLU54F, GLY102B, GLY324B, GLY96F, ILE115B, ILE115F, ILE119F, ILE325B, LEU106B, LEU108B, LEU57F, LYS117F, LYS231B, LYS242B, LYS56F, LYS80F, MET53F, PHE116F, PHE118F, PRO121F, SER104B, THR321B, TYR238B, TYR82F, VAL109B, VAL113F, VAL50F, VAL52F
• C-D: ALA167C, ALA167D, ALA181C, ALA181D, ALA1C, ALA1D, ALA206C, ALA206D, ALA237C, ALA237D, ALA250C, ALA250D, ALA256C, ALA256D, ALA29C, ALA29D, ALA2C, ALA2D, ALA33C, ALA33D, ALA35C, ALA35D, ARG168C, ARG168D, ARG170C, ARG170D, ARG176C, ARG176D, ARG268C, ARG268D, ARG72C, ARG72D, ASN163C, ASN163D, ASN204C, ASN204D, ASP165C, ASP165D, ASP222C, ASP222D, ASP235C, ASP235D, ASP257C, ASP257D, ASP42C, ASP42D, ASP55C, ASP55D, ASP5C, ASP5D, ASP63C, ASP63D, CYS184C, CYS184D, CYS34C, CYS34D, GLN232C, GLN232D, GLN65C, GLN65D, GLN6C, GLN6D, GLU14C, GLU175C, GLU175D, GLU216C, GLU216D, GLU224C, GLU224D, GLU239C, GLU239D, GLU260C, GLU260D, GLU54C, GLU54D, GLU60C, GLU60D, GLY174C, GLY174D, GLY178C, GLY178D, GLY186D, GLY207C, GLY207D, GLY218D, GLY245C, GLY245D, GLY252C, GLY252D, GLY28C, GLY28D, GLY31C, GLY31D, GLY59C, GLY59D, GLY67C, GLY67D, HIS180C, HIS180D, HIS185C, HIS185D, HIS214C, HIS214D, HIS270C, HIS270D, HIS66C, HIS66D, ILE241C, ILE241D, ILE251C, ILE251D, ILE36C, ILE36D, ILE38C, ILE38D, ILE76C, ILE76D, ILE8C, ILE8D, LEU164C, LEU164D, LEU172C, LEU172D, LEU177C, LEU177D, LEU182C, LEU182D, LEU210C, LEU210D, LEU213C, LEU213D, LEU217C, LEU217D, LEU243C, LEU243D, LEU253C, LEU253D, LEU258C, LEU258D, LEU39C, LEU39D, LEU3C, LEU3D, LEU43C, LEU43D, LEU49D, LEU57C, LEU57D, LEU64C, LEU64D, LEU69C, LEU69D, LEU71C, LEU71D, LEU7C, LEU7D, LYS211C, LYS211D, LYS223C, LYS223D, LYS242C, LYS242D, LYS244C, LYS244D, LYS41C, LYS41D, LYS4C, LYS4D, LYS56C, LYS56D, LYS58C, LYS58D, LYS75C, LYS75D, MET173C, MET173D, MET203C, MET203D, MET32C, MET32D, MET40C, MET40D, MET53C, MET53D, MET61C, MET61D, MET62C, MET62D, PHE169C, PHE169D, PHE70C, PHE70D, PRO215C, PRO215D, PRO271C, PRO271D, PRO74C, PRO74D, SER166C, SER166D, SER183C, SER183D, SER209C, SER209D, SER236C, SER236D, SER254C, SER254D, SER37C, SER37D, SER68C, SER68D, THR212C, THR212D, THR247C, THR247D, THR248C, THR248D, THR73C, THR73D, TRP226C, TRP226D, TRP249C, TRP249D, TYR171C, TYR171D, TYR238C, TYR246C, TYR246D, VAL179C, VAL179D, VAL205C, VAL205D, VAL208C, VAL208D, VAL233C, VAL233D, VAL240C, VAL240D, VAL255C, VAL255D, VAL27C, VAL27D
• E-F: ALA167E, ALA167F, ALA181E, ALA181F, ALA1E, ALA1F, ALA206E, ALA206F, ALA237E, ALA237F, ALA250E, ALA250F, ALA256E, ALA256F, ALA29E, ALA29F, ALA2E, ALA2F, ALA33E, ALA33F, ALA35E, ALA35F, ARG168E, ARG168F, ARG170E, ARG170F, ARG176E, ARG176F, ARG268E, ARG268F, ARG72E, ARG72F, ASN163E, ASN163F, ASN204E, ASN204F, ASP165E, ASP165F, ASP222E, ASP222F, ASP235E, ASP235F, ASP257E, ASP257F, ASP42E, ASP42F, ASP55E, ASP55F, ASP5E, ASP5F, ASP63E, ASP63F, CYS162F, CYS184E, CYS184F, CYS34E, CYS34F, GLN232E, GLN232F, GLN65E, GLN65F, GLN6E, GLN6F, GLU175E, GLU175F, GLU216F, GLU224E, GLU224F, GLU239E, GLU239F, GLU260E, GLU260F, GLU54E, GLU54F, GLU60E, GLU60F, GLY174E, GLY174F, GLY178E, GLY178F, GLY186F, GLY207E, GLY207F, GLY218E, GLY245E, GLY245F, GLY252E, GLY252F, GLY28E, GLY28F, GLY31E, GLY31F, GLY59E, GLY59F, GLY67E, GLY67F, HIS180E, HIS180F, HIS185E, HIS185F, HIS214E, HIS214F, HIS270E, HIS270F, HIS66E, HIS66F, ILE241E, ILE241F, ILE251E, ILE251F, ILE36E, ILE36F, ILE38E, ILE38F, ILE76E, ILE76F, ILE8E, ILE8F, LEU164E, LEU164F, LEU172E, LEU172F, LEU177E, LEU177F, LEU182E, LEU182F, LEU210E, LEU210F, LEU213E, LEU213F, LEU217E, LEU217F, LEU243E, LEU243F, LEU253E, LEU253F, LEU258E, LEU258F, LEU39E, LEU39F, LEU3E, LEU3F, LEU43E, LEU43F, LEU49E, LEU49F, LEU57E, LEU57F, LEU64E, LEU64F, LEU69E, LEU69F, LEU71E, LEU71F, LEU7E, LEU7F, LYS211E, LYS211F, LYS223E, LYS223F, LYS242E, LYS242F, LYS244E, LYS244F, LYS41E, LYS41F, LYS4E, LYS4F, LYS56E, LYS56F, LYS58E, LYS58F, LYS75E, LYS75F, MET173E, MET173F, MET203E, MET203F, MET32E, MET32F, MET40E, MET40F, MET53E, MET53F, MET61E, MET61F, MET62E, MET62F, PHE169E, PHE169F, PHE70E, PHE70F, PRO215E, PRO215F, PRO271E, PRO271F, PRO74E, PRO74F, SER166E, SER166F, SER183E, SER183F, SER209E, SER209F, SER236E, SER236F, SER254E, SER254F, SER37E, SER37F, SER68E, SER68F, THR212E, THR212F, THR247E, THR247F, THR248E, THR248F, THR73E, THR73F, TRP226E, TRP226F, TRP249E, TRP249F, TYR171E, TYR171F, TYR238E, TYR238F, TYR246E, TYR246F, VAL179E, VAL179F, VAL205E, VAL205F, VAL208E, VAL208F, VAL233E, VAL233F, VAL240E, VAL240F, VAL255E, VAL255F, VAL27E, VAL27F
• E-G: ALA181E, ALA181G, ALA206E, ALA206G, ARG170E, ARG170G, ARG267E, ARG267G, ARG268E, ARG268G, ARG72E, ARG72G, ASN204E, ASN204G, ASN265E, ASN265G, ASP301E, ASP301G, CYS184E, CYS184G, CYS292E, CYS292G, GLU175E, GLU260E, GLY174E, GLY174G, GLY178E, GLY178G, GLY186E, GLY186G, GLY202E, GLY202G, GLY207E, GLY207G, HIS180E, HIS180G, HIS185E, HIS185G, HIS270E, HIS270G, LEU177E, LEU177G, LEU182E, LEU182G, LEU189E, LEU189G, LEU210G, LEU213E, LEU213G, LEU266E, LEU266G, LEU294E, LEU294G, LEU307E, LEU307G, LYS264E, LYS264G, LYS304E, LYS304G, MET203E, MET203G, PHE70E, PHE70G, PRO271E, PRO271G, PRO291E, PRO291G, SER183E, SER183G, SER201E, SER201G, SER209E, SER209G, SER261E, SER261G, SER300E, SER300G, THR212E, THR212G, THR306E, THR306G, TRP187E, TRP187G, TYR280E, TYR280G, VAL179E, VAL179G, VAL199E, VAL199G, VAL205E, VAL205G, VAL208E, VAL208G, VAL269E, VAL269G, VAL290E, VAL290G, VAL293E, VAL293G, VAL303E, VAL303G, VAL305E, VAL305G
• E-H: ALA1E, ALA1H, ALA2E, ALA2H, ALA44E, ALA44H, ARG156E, ARG156H, ARG267E, ARG267H, ARG268E, ARG268H, ARG72E, ARG72H, ASN10E, ASN10H, ASN155E, ASN155H, ASN20E, ASN20H, ASN265E, ASN265H, ASN297E, ASN297H, ASP257E, ASP257H, ASP301E, ASP301H, ASP42E, ASP42H, ASP45E, ASP45H, ASP5E, ASP5H, CYS292E, CYS292H, GLN19E, GLN19H, GLN296E, GLN296H, GLN6E, GLN6H, GLU14E, GLU14H, GLU15E, GLU15H, GLU260E, GLU260H, GLU46E, GLU46H, GLY278E, GLY278H, GLY295E, GLY295H, GLY298E, GLY298H, HIS16E, HIS16H, HIS270H, HIS9E, HIS9H, ILE262E, ILE262H, ILE299E, ILE299H, ILE8E, ILE8H, LEU11E, LEU11H, LEU12E, LEU12H, LEU182E, LEU182H, LEU266E, LEU266H, LEU276E, LEU276H, LEU279E, LEU279H, LEU3E, LEU3H, LEU43E, LEU43H, LEU71E, LEU71H, LEU7E, LEU7H, LYS131E, LYS131H, LYS13E, LYS13H, LYS154E, LYS154H, LYS264E, LYS264H, LYS277E, LYS277H, LYS304E, LYS304H, LYS41E, LYS41H, LYS4E, LYS4H, LYS75E, LYS75H, LYS89E, LYS89H, MET263E, MET263H, MET275E, MET275H, PRO153E, PRO153H, PRO18E, PRO18H, PRO291E, PRO291H, PRO74E, PRO74H, SER261E, SER261H, SER300E, SER300H, SER68H, THR274E, THR274H, THR306E, THR306H, THR73E, THR73H, TYR280E, TYR280H, VAL17E, VAL17H, VAL269E, VAL269H, VAL290E, VAL293E, VAL293H, VAL302E, VAL302H, VAL303E, VAL303H, VAL305E, VAL305H
• F-G: ALA1G, ALA2F, ALA2G, ALA44F, ALA44G, ARG156F, ARG156G, ARG267F, ARG267G, ARG268F, ARG268G, ARG72F, ARG72G, ASN10F, ASN10G, ASN155F, ASN155G, ASN20F, ASN20G, ASN265F, ASN265G, ASN297F, ASN297G, ASP257F, ASP257G, ASP301F, ASP301G, ASP42F, ASP42G, ASP45F, ASP45G, ASP5F, ASP5G, CYS292F, CYS292G, GLN19F, GLN19G, GLN296F, GLN296G, GLN6F, GLN6G, GLU14F, GLU14G, GLU15F, GLU15G, GLU260F, GLU260G, GLU46F, GLU46G, GLY278F, GLY278G, GLY295F, GLY295G, GLY298F, GLY298G, HIS16F, HIS16G, HIS270F, HIS9F, HIS9G, ILE262F, ILE262G, ILE299F, ILE299G, ILE8F, ILE8G, LEU11F, LEU11G, LEU12F, LEU12G, LEU182F, LEU182G, LEU266F, LEU266G, LEU276F, LEU276G, LEU279F, LEU279G, LEU3F, LEU3G, LEU43F, LEU43G, LEU69F, LEU69G, LEU71F, LEU71G, LEU7F, LEU7G, LYS131F, LYS131G, LYS13F, LYS13G, LYS154F, LYS154G, LYS264F, LYS264G, LYS277F, LYS277G, LYS304F, LYS304G, LYS41F, LYS41G, LYS4F, LYS4G, LYS75F, LYS75G, LYS89F, LYS89G, MET263F, MET263G, MET275F, MET275G, PRO153F, PRO153G, PRO18F, PRO18G, PRO291F, PRO291G, PRO74F, PRO74G, SER261F, SER261G, SER300F, SER300G, SER68F, SER68G, THR274F, THR274G, THR306F, THR306G, THR73F, THR73G, TYR280F, TYR280G, VAL17F, VAL17G, VAL269F, VAL269G, VAL290F, VAL290G, VAL293F, VAL293G, VAL302F, VAL302G, VAL303F, VAL303G, VAL305F, VAL305G
• F-H: ALA181F, ALA181H, ALA206F, ALA206H, ARG170F, ARG170H, ARG267F, ARG267H, ARG268F, ARG268H, ARG72F, ARG72H, ASN204F, ASN204H, ASN265F, ASN265H, ASP301F, ASP301H, CYS184F, CYS184H, CYS292F, CYS292H, GLU175F, GLU260F, GLU260H, GLY174F, GLY174H, GLY178F, GLY178H, GLY186F, GLY186H, GLY202F, GLY202H, GLY207F, GLY207H, HIS180F, HIS180H, HIS185F, HIS185H, HIS270F, HIS270H, LEU177F, LEU177H, LEU182F, LEU182H, LEU189F, LEU189H, LEU210F, LEU210H, LEU213F, LEU213H, LEU266F, LEU266H, LEU294F, LEU294H, LEU307F, LEU307H, LYS264F, LYS264H, LYS304F, LYS304H, MET203F, MET203H, PRO271F, PRO271H, PRO291F, PRO291H, SER183F, SER183H, SER201F, SER201H, SER209F, SER209H, SER261F, SER261H, SER300F, SER300H, THR212F, THR212H, THR306F, THR306H, TRP187F, TRP187H, TYR280F, TYR280H, VAL179F, VAL179H, VAL199F, VAL199H, VAL205F, VAL205H, VAL208F, VAL208H, VAL269F, VAL269H, VAL290F, VAL290H, VAL293F, VAL293H, VAL303F, VAL303H, VAL305F, VAL305H
• G-H: ALA167G, ALA167H, ALA181G, ALA181H, ALA1G, ALA1H, ALA206G, ALA206H, ALA237G, ALA237H, ALA250G, ALA250H, ALA256G, ALA256H, ALA29G, ALA29H, ALA2G, ALA2H, ALA33G, ALA33H, ALA35G, ALA35H, ARG168G, ARG168H, ARG170G, ARG170H, ARG176G, ARG176H, ARG268G, ARG268H, ARG72G, ARG72H, ASN163G, ASN163H, ASN204G, ASN204H, ASP165G, ASP165H, ASP222G, ASP222H, ASP235G, ASP235H, ASP257G, ASP257H, ASP42G, ASP42H, ASP55G, ASP55H, ASP5G, ASP5H, ASP63G, ASP63H, CYS184G, CYS184H, CYS34G, CYS34H, GLN232G, GLN232H, GLN65G, GLN65H, GLN6G, GLN6H, GLU14H, GLU175G, GLU175H, GLU216G, GLU216H, GLU224G, GLU224H, GLU239G, GLU239H, GLU260G, GLU260H, GLU54G, GLU54H, GLU60G, GLU60H, GLY174G, GLY174H, GLY178G, GLY178H, GLY186G, GLY186H, GLY207G, GLY207H, GLY218H, GLY245G, GLY245H, GLY252G, GLY252H, GLY28G, GLY28H, GLY31G, GLY31H, GLY59G, GLY59H, GLY67G, GLY67H, HIS180G, HIS180H, HIS185G, HIS185H, HIS214G, HIS214H, HIS270G, HIS270H, HIS66G, HIS66H, ILE241G, ILE241H, ILE251G, ILE251H, ILE36G, ILE36H, ILE38G, ILE38H, ILE76G, ILE76H, ILE8G, ILE8H, LEU164G, LEU164H, LEU172G, LEU172H, LEU177G, LEU177H, LEU182G, LEU182H, LEU210G, LEU210H, LEU213G, LEU213H, LEU217G, LEU217H, LEU243G, LEU243H, LEU253G, LEU253H, LEU258G, LEU258H, LEU39G, LEU39H, LEU3G, LEU3H, LEU43G, LEU43H, LEU57G, LEU57H, LEU64G, LEU64H, LEU69G, LEU69H, LEU71G, LEU71H, LEU7G, LEU7H, LYS211G, LYS211H, LYS223G, LYS223H, LYS242G, LYS242H, LYS244G, LYS244H, LYS41G, LYS41H, LYS4G, LYS4H, LYS56G, LYS56H, LYS58G, LYS58H, LYS75G, LYS75H, MET173G, MET173H, MET203G, MET203H, MET32G, MET32H, MET40G, MET40H, MET53G, MET53H, MET61G, MET61H, MET62G, MET62H, PHE169G, PHE169H, PHE70G, PHE70H, PRO215G, PRO215H, PRO271G, PRO271H, PRO74G, PRO74H, SER166G, SER166H, SER183G, SER183H, SER209G, SER209H, SER236G, SER236H, SER254G, SER254H, SER37G, SER37H, SER68G, SER68H, THR212G, THR212H, THR247G, THR247H, THR248G, THR248H, THR73G, THR73H, TRP226G, TRP226H, TRP249G, TRP249H, TYR171G, TYR171H, TYR238G, TYR238H, TYR246G, TYR246H, VAL179G, VAL179H, VAL205G, VAL205H, VAL208G, VAL208H, VAL233G, VAL233H, VAL240G, VAL240H, VAL255G, VAL255H, VAL27G, VAL27H, VAL30H, VAL77H