3H1C

crystal structure of polynucleotide phosphorylase (pnpase) core bound to rnase e and tungstate

• Total interactions analyzed: 276
• Total true interactions: 52
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 74
  • Norm. En. per Res.: -4.6683
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-62.7549	-29.5059	-217.589	-309.8498	73	13	8	8551	0	11	10
A-B	-70.3854	-94.8791	-399.781	-565.0455	166	31	8	18552	8	40	42
A-C	-73.8653	-94.9402	-437.585	-606.3905	173	37	8	19174	7	41	39
A-F	-2.2682	-4.2583	-71.322	-77.8485	43	8	2	3087	1	3	2
A-T	0.0	12.4384	-16.9692	-4.5308	38	1	0	1059	0	22	22
A-X	0.0	-11.1536	-17.6561	-28.8097	23	0	0	1128	0	6	6
D-B	-7.7257	-14.4155	-58.2552	-80.3964	42	3	1	2579	2	3	2
B-E	-62.0042	-29.838	-221.917	-313.7592	75	9	8	8568	2	11	10
B-C	-53.1357	-68.9355	-441.18	-563.2512	176	35	7	19641	3	42	43
B-I	0.0	5.4735	-64.7831	-59.3096	44	4	2	3208	5	30	33
B-K	0.0	22.1415	-12.4092	9.7324	31	1	0	852	0	16	16
B-X	0.0	9.5077	-2.7708	6.737	21	0	0	245	0	3	3
E-C	-11.3613	-13.9331	-67.1755	-92.4699	42	15	1	3297	2	2	2
E-K	-13.5506	0.0	-38.9016	-52.4522	23	4	1	1540	0	4	6
C-F	-55.0403	-19.5903	-114.485	-189.1155	74	20	7	8264	0	11	10
C-I	0.0	21.6856	-5.7238	15.9617	24	0	0	525	0	15	14
C-J	-11.6349	1.1723	-33.907	-44.3696	24	2	1	1292	0	4	6
C-K	0.0	0.0	3.7376	3.7376	17	11	0	799	0	0	0
C-V	0.0	0.0	-16.7154	-16.7154	18	1	0	799	0	3	5
C-X	0.0	-8.5	-0.148	-8.648	4	0	0	33	0	6	6
G-H	-75.6467	-15.6758	-205.305	-296.6275	76	8	9	8429	2	11	10
G-I	-85.2051	-81.3164	-416.134	-582.6555	175	41	8	19157	3	41	42
G-K	-72.439	-84.3212	-381.252	-538.0122	171	40	8	19044	5	43	43
G-L	0.0	-15.9205	-69.2439	-85.1644	41	2	1	2898	2	3	3
G-M	0.0	-3.5417	-0.3997	-3.9414	8	0	0	45	0	4	5
G-R	0.0	0.0	-32.7612	-32.7612	26	3	0	1337	0	4	6
H-I	0.0	-11.5984	-66.6744	-78.2728	36	5	2	2819	1	3	2
I-J	-78.5568	-33.662	-233.237	-345.4558	74	10	8	8770	3	11	10
I-K	-63.3017	-95.8735	-443.692	-602.8673	171	28	8	19716	9	39	43
I-M	0.0	15.6159	-43.5167	-27.9008	32	3	0	1924	0	6	6
I-O	-14.8782	10.4403	-54.2195	-58.6574	58	11	0	2980	1	29	32
J-K	-14.0676	-10.8015	-65.5732	-90.4423	42	10	1	3196	1	2	2
K-L	-65.089	-28.9248	-221.284	-315.2978	76	16	6	8674	2	11	10
K-M	0.0	-8.6007	-13.4634	-22.0641	29	0	0	982	0	10	12
M-N	-58.0054	-24.8316	-223.986	-306.8231	72	8	7	8369	1	11	10
M-O	-94.7652	-95.7284	-419.897	-610.3906	172	34	7	19773	9	41	45
M-R	-50.8782	-106.4893	-427.75	-585.1176	172	21	8	19135	6	39	44
M-S	0.0	0.0	-58.2748	-58.2748	41	3	1	2874	0	3	2
N-O	-2.3519	-13.3256	-60.1911	-75.8686	42	6	1	2649	2	2	2
O-P	-73.5469	-22.1815	-209.587	-305.3153	75	11	8	8364	0	11	10
O-R	-61.305	-115.8475	-429.489	-606.6415	171	43	8	19676	8	43	41
P-R	-16.5822	-12.9012	-70.6713	-100.1548	42	2	1	2983	2	3	2
R-S	-70.4661	-24.7067	-211.085	-306.2578	73	10	7	8136	0	11	10
T-U	-65.4168	-47.6798	-212.545	-325.6416	74	11	7	8119	3	11	10
T-V	-77.1946	-128.7104	-425.628	-631.5329	169	33	6	19245	9	40	42
T-X	-61.1585	-31.046	-259.99	-352.1945	159	24	6	15306	0	35	37
T-Y	-2.3245	-12.0083			3
U-V	-10.673	-15.5915	-74.6983	-100.9628	44	4	1	2905	2	2	3
V-W	-13.4894	-22.6685	-222.336	-258.4939	75	12	7	8589	0	11	11
V-X	-90.3404	-119.7176	-422.148	-632.2061	169	44	7	18885	11	41	44
W-X	-4.0682	0.0	-37.3155	-41.3837	40	2	2	2057	0	2	2
X-Y	-73.6944	-31.0876			18

Interface residues

• A-D: ALA1040D, ALA1041D, ALA1046D, ALA1050D, ALA1052D, ALA1053D, ALA1055D, ALA341A, ALA526A, ALA529A, ALA540A, ALA543A, ARG1056D, ARG319A, ARG325A, ARG330A, ARG336A, ARG345A, ARG499A, ARG530A, ASN524A, ASN542A, ASP317A, ASP322A, ASP328A, ASP452A, GLN1058D, GLN525A, GLN539A, GLU320A, GLU538A, GLY1039D, GLY1042D, GLY1043D, GLY318A, GLY326A, GLY332A, GLY346A, GLY528A, GLY535A, HIS1044D, HIS1048D, HIS1049D, HIS532A, ILE324A, ILE533A, ILE541A, LEU327A, LEU334A, LEU342A, LEU351A, LEU448A, LEU531A, LYS321A, LYS527A, MET323A, MET466A, MET537A, PRO1054D, PRO1057D, PRO1059D, PRO335A, SER1051D, SER340A, SER479A, THR1045D, THR1047D, THR261A, THR331A, THR344A, VAL329A, VAL333A, VAL536A
• A-B: ALA115B, ALA24B, ALA268A, ALA27B, ALA29B, ALA30B, ALA350A, ALA354A, ALA359A, ALA362A, ALA39B, ALA69B, ALA70B, ARG25B, ARG266A, ARG325A, ARG330A, ARG336A, ARG345A, ARG360A, ARG398B, ARG405A, ARG426A, ARG66B, ARG72B, ARG79B, ARG80B, ARG83A, ARG83B, ASN121B, ASN381A, ASN3B, ASN435A, ASN62B, ASP262A, ASP271A, ASP328A, ASP361A, ASP366A, ASP36B, ASP374A, ASP37B, GLN112B, GLN123B, GLN264A, GLN26B, GLN349A, GLN363A, GLN47B, GLN64B, GLU110B, GLU19B, GLU347A, GLU389A, GLU400A, GLU430A, GLU433A, GLU81B, GLU86A, GLY326A, GLY339A, GLY346A, GLY357A, GLY388A, GLY391A, GLY394A, GLY404A, GLY46B, GLY483A, GLY71B, GLY75A, GLY75B, GLY82B, GLY87A, HIS338A, HIS379A, ILE114B, ILE401A, ILE431A, ILE73B, LEU2B, LEU327A, LEU334A, LEU342A, LEU351A, LEU356A, LEU365A, LEU377A, LYS228B, LYS263A, LYS397A, LYS48B, LYS49B, MET1B, MET22B, MET23B, MET32B, MET392A, PHE378A, PHE382A, PHE41B, PHE77B, PHE78B, PRO122B, PRO335A, PRO383A, PRO384A, PRO396A, PRO4B, PRO58B, PRO74B, PRO84A, PRO84B, SER119B, SER275A, SER340A, SER34B, SER386A, SER395A, SER429A, SER434A, SER76A, SER76B, SER85A, THR116B, THR28B, THR337A, THR344A, THR348A, THR353A, THR355A, THR358A, THR373A, THR375A, THR38B, THR390A, THR424A, THR432A, THR43B, THR60B, THR67B, TYR267A, TYR380A, TYR385A, TYR423A, TYR63B, TYR68B, VAL111B, VAL113B, VAL117B, VAL118B, VAL120B, VAL124B, VAL272A, VAL329A, VAL333A, VAL352A, VAL364A, VAL387A, VAL393A, VAL425A, VAL427A, VAL428A, VAL42B, VAL44B, VAL45B
• A-C: ALA115A, ALA24A, ALA268C, ALA27A, ALA29A, ALA30A, ALA354C, ALA359C, ALA362C, ALA39A, ALA69A, ALA70A, ARG25A, ARG266C, ARG325C, ARG330C, ARG336C, ARG345C, ARG360C, ARG398A, ARG405C, ARG426C, ARG66A, ARG72A, ARG79A, ARG80A, ARG83A, ARG83C, ASN121A, ASN381C, ASN3A, ASN435C, ASN62A, ASP262C, ASP271C, ASP328C, ASP361C, ASP366C, ASP36A, ASP374C, ASP37A, GLN112A, GLN123A, GLN264C, GLN26A, GLN349C, GLN363C, GLN47A, GLN64A, GLU110A, GLU19A, GLU265C, GLU276C, GLU347C, GLU371C, GLU389C, GLU400C, GLU430C, GLU433C, GLU81A, GLU86C, GLU88C, GLY326C, GLY339C, GLY346C, GLY357C, GLY388C, GLY391C, GLY394C, GLY402C, GLY404C, GLY46A, GLY71A, GLY75A, GLY75C, GLY82A, GLY87C, HIS338C, HIS379C, HIS403C, ILE114A, ILE401C, ILE431C, ILE73A, LEU2A, LEU327C, LEU334C, LEU342C, LEU351C, LEU356C, LEU365C, LEU377C, LEU59A, LYS228A, LYS263C, LYS397C, LYS48A, LYS49A, MET1A, MET22A, MET23A, MET32A, MET392C, PHE378C, PHE382C, PHE41A, PHE77A, PHE78A, PRO122A, PRO335C, PRO383C, PRO384C, PRO396C, PRO4A, PRO58A, PRO74A, PRO84A, PRO84C, SER119A, SER275C, SER340C, SER34A, SER386C, SER395C, SER429C, SER434C, SER76A, SER76C, SER85C, THR116A, THR261C, THR28A, THR337C, THR344C, THR348C, THR353C, THR355C, THR358C, THR373C, THR375C, THR38A, THR390C, THR424C, THR432C, THR43A, THR60A, THR67A, TYR267C, TYR380C, TYR385C, TYR423C, TYR63A, TYR68A, VAL111A, VAL113A, VAL117A, VAL118A, VAL120A, VAL124A, VAL272C, VAL329C, VAL333C, VAL352C, VAL364C, VAL387C, VAL393C, VAL425C, VAL427C, VAL428C, VAL42A, VAL44A, VAL45A, VAL61A
• A-F: ALA1040F, ALA1041F, ALA1046F, ALA1050F, ALA1052F, ALA1053F, ALA39A, ARG7A, ASN121A, ASN3A, ASP36A, ASP37A, GLU19A, GLY1039F, GLY1042F, GLY1043F, HIS1044F, HIS1049F, ILE5A, LEU18A, LEU2A, LYS8A, MET1A, MET22A, MET23A, MET32A, MET35A, PHE41A, PRO1054F, PRO4A, SER1051F, SER119A, SER34A, THR1045F, THR15A, THR17A, THR20A, THR38A, VAL118A, VAL16A, VAL33A, VAL40A, VAL6A
• A-T: ALA359A, ALA359T, ALA70T, ARG360A, ARG360T, ARG72T, ASN121T, ASN158A, ASP168A, ASP168T, ASP417A, ASP419A, ASP419T, GLN123A, GLN123T, GLN167T, GLU172A, GLU371T, GLY370T, GLY71T, ILE157A, ILE73T, LYS171A, LYS171T, LYS420A, LYS420T, MET369T, MET418A, MET418T, PHE421A, PRO122T, PRO422A, PRO422T, PRO456A, THR166T, THR358A, THR373T, TYR423A
• A-X: ALA359A, ALA359X, ALA362A, ARG336X, ARG360A, ARG360X, ARG372A, ASP361A, ASP361X, GLN363A, GLU371A, GLY357X, HIS338X, LEU356X, LEU365A, LYS420A, PHE421A, PRO422A, THR358A, THR358X, THR373A, TYR423A, VAL364A
• D-B: ALA1040D, ALA1041D, ALA1046D, ALA1050D, ALA1052D, ALA1053D, ALA39B, ARG7B, ASN121B, ASN3B, ASP36B, ASP37B, GLU19B, GLY1039D, GLY1042D, GLY1043D, HIS1044D, HIS1049D, ILE5B, LEU18B, LEU2B, LYS8B, MET1B, MET22B, MET23B, MET32B, MET35B, PHE41B, PRO1054D, PRO4B, SER1051D, SER119B, SER34B, THR1045D, THR15B, THR17B, THR38B, VAL118B, VAL16B, VAL33B, VAL40B, VAL6B
• B-E: ALA1040E, ALA1041E, ALA1046E, ALA1050E, ALA1052E, ALA1053E, ALA1055E, ALA341B, ALA526B, ALA529B, ALA540B, ALA543B, ARG1056E, ARG319B, ARG325B, ARG330B, ARG336B, ARG345B, ARG499B, ARG530B, ASN524B, ASN542B, ASP317B, ASP322B, ASP328B, ASP452B, GLN1058E, GLN525B, GLN539B, GLU320B, GLU538B, GLY1039E, GLY1042E, GLY1043E, GLY318B, GLY326B, GLY332B, GLY346B, GLY528B, GLY535B, HIS1044E, HIS1048E, HIS1049E, HIS532B, ILE324B, ILE464B, ILE533B, ILE541B, LEU327B, LEU334B, LEU342B, LEU351B, LEU448B, LEU531B, LEU534B, LYS321B, LYS527B, MET323B, MET466B, MET537B, PHE343B, PRO1054E, PRO1057E, PRO1059E, PRO335B, SER1051E, SER340B, SER479B, THR1045E, THR1047E, THR331B, THR344B, VAL329B, VAL333B, VAL536B
• B-C: ALA115C, ALA24C, ALA268B, ALA27C, ALA29C, ALA30C, ALA341B, ALA354B, ALA359B, ALA362B, ALA39C, ALA69C, ALA70C, ARG25C, ARG266B, ARG330B, ARG336B, ARG345B, ARG360B, ARG398C, ARG405B, ARG426B, ARG66C, ARG72C, ARG79C, ARG80C, ARG83B, ARG83C, ASN109C, ASN121C, ASN381B, ASN3C, ASN435B, ASN62C, ASP262B, ASP271B, ASP328B, ASP361B, ASP366B, ASP36C, ASP374B, ASP37C, GLN112C, GLN123C, GLN264B, GLN26C, GLN349B, GLN363B, GLN47C, GLN64C, GLU110C, GLU19C, GLU276B, GLU347B, GLU367B, GLU389B, GLU400B, GLU430B, GLU433B, GLU81C, GLU86B, GLU88B, GLY21C, GLY326B, GLY339B, GLY346B, GLY357B, GLY388B, GLY391B, GLY394B, GLY402B, GLY404B, GLY46C, GLY71C, GLY75B, GLY75C, GLY82C, GLY87B, HIS338B, HIS379B, ILE114C, ILE401B, ILE431B, ILE73C, LEU2C, LEU327B, LEU334B, LEU342B, LEU351B, LEU356B, LEU365B, LEU377B, LYS228C, LYS263B, LYS274B, LYS397B, LYS48C, LYS49C, MET1C, MET22C, MET23C, MET32C, MET35C, MET392B, PHE343B, PHE376B, PHE378B, PHE382B, PHE41C, PHE77C, PHE78C, PRO122C, PRO335B, PRO383B, PRO384B, PRO396B, PRO4C, PRO58C, PRO74C, PRO84B, PRO84C, SER119C, SER275B, SER340B, SER34C, SER386B, SER395B, SER429B, SER434B, SER76B, SER76C, SER85B, THR116C, THR28C, THR337B, THR344B, THR348B, THR353B, THR355B, THR358B, THR373B, THR375B, THR38C, THR390B, THR424B, THR432B, THR43C, THR60C, THR67C, THR89B, TYR267B, TYR380B, TYR385B, TYR423B, TYR63C, TYR68C, VAL111C, VAL113C, VAL117C, VAL118C, VAL120C, VAL124C, VAL272B, VAL329B, VAL333B, VAL352B, VAL364B, VAL387B, VAL393B, VAL425B, VAL427B, VAL428B, VAL42C, VAL44C, VAL45C, VAL61C
• B-I: ALA248B, ALA248I, ALA250B, ALA250I, ALA252B, ALA252I, ALA257B, ALA257I, ALA268B, ALA268I, ARG253B, ARG253I, ARG259B, ARG259I, ARG266I, ARG308B, ARG308I, ASP256B, ASP256I, ASP262B, ASP262I, GLN269B, GLN269I, GLU251B, GLU251I, GLU265B, GLU265I, GLU276B, GLU276I, ILE260B, ILE260I, ILE273B, ILE273I, LEU249B, LEU249I, LEU254B, LEU254I, SER255B, SER255I, THR261B, THR261I, TYR258B, VAL272B, VAL272I
• B-K: ARG230K, ARG319B, ARG325B, ARG7K, ASP232K, ASP317B, GLN234K, GLN539B, GLU221K, GLU225K, GLU313B, GLU320B, GLY312B, GLY318B, GLY326B, GLY535B, HIS532B, ILE324B, ILE533B, LEU327B, LEU531B, LYS224K, LYS228K, LYS321B, MET323B, PRO229K, PRO314B, THR261B, TRP231K, TRP233K, VAL536B
• B-X: ALA359B, ARG360B, ARG79B, ASN158X, ASP159X, ASP361B, ASP417X, ASP419B, ASP419X, ASP500X, GLN194X, GLU172X, GLU371B, LEU170X, LYS171X, LYS174X, LYS420X, SER173X, THR358B, THR358X, TYR423B
• E-C: ALA1040E, ALA1041E, ALA1046E, ALA1050E, ALA1052E, ALA1053E, ALA39C, ARG7C, ASN3C, ASP36C, ASP37C, GLU19C, GLY1039E, GLY1042E, GLY1043E, HIS1044E, HIS1049E, ILE5C, LEU18C, LEU2C, LYS8C, MET1C, MET22C, MET23C, MET32C, MET35C, PHE41C, PRO1054E, PRO4C, SER1051E, SER119C, SER34C, THR1045E, THR15C, THR17C, THR20C, THR38C, VAL118C, VAL16C, VAL33C, VAL40C, VAL6C
• E-K: ALA1050E, ALA1052E, ALA1053E, ALA1055E, ALA226K, ARG1056E, ARG230K, ASP232K, GLN1058E, GLN234K, GLU221K, GLU225K, GLY227K, HIS1049E, ILE5K, LEU140K, LEU222K, LYS224K, LYS228K, PRO1054E, PRO229K, SER1051E, VAL223K
• C-F: ALA1040F, ALA1041F, ALA1046F, ALA1050F, ALA1052F, ALA1053F, ALA1055F, ALA341C, ALA526C, ALA529C, ALA540C, ALA543C, ARG1056F, ARG315C, ARG319C, ARG325C, ARG330C, ARG336C, ARG345C, ARG499C, ARG530C, ASN524C, ASP322C, ASP328C, ASP452C, ASP480C, GLN1058F, GLN349C, GLN525C, GLN539C, GLU320C, GLU538C, GLY1039F, GLY1042F, GLY1043F, GLY326C, GLY332C, GLY346C, GLY528C, GLY535C, HIS1044F, HIS1048F, HIS1049F, HIS532C, ILE324C, ILE464C, ILE533C, ILE541C, LEU327C, LEU334C, LEU342C, LEU351C, LEU448C, LEU531C, LYS321C, LYS527C, MET323C, MET451C, MET466C, MET537C, PRO1054F, PRO1057F, PRO1059F, PRO335C, SER1051F, SER340C, SER479C, THR1045F, THR1047F, THR331C, THR344C, VAL329C, VAL333C, VAL536C
• C-I: ARG230C, ARG319I, ARG7C, ASP232C, ASP317I, GLN234C, GLN539I, GLU221C, GLU225C, GLU313I, GLU320I, GLY312I, GLY318I, GLY326I, GLY535I, HIS532I, LEU327I, LYS224C, MET323I, PRO229C, PRO314I, THR261I, TRP231C, VAL536I
• C-J: ALA1050J, ALA1052J, ALA1053J, ALA1055J, ALA226C, ARG1056J, ARG230C, ASP232C, GLN1058J, GLN234C, GLU221C, GLU225C, GLY227C, HIS1049J, ILE5C, LEU140C, LEU222C, LYS224C, LYS228C, PRO1054J, PRO1057J, PRO229C, SER1051J, VAL223C
• C-K: ALA226C, ALA226K, ASN3C, ASN3K, GLU225C, GLU225K, GLY21C, GLY227K, ILE5C, ILE5K, LEU2C, LEU2K, MET1C, MET1K, PRO4C, PRO4K, VAL6K
• C-V: ALA359C, ALA359V, ARG360C, ARG360V, ASP361V, ASP419C, GLY357V, LEU356V, LYS420C, PHE421C, PHE421V, PRO422C, PRO422V, PRO456C, THR358C, THR358V, TYR423C, TYR423V
• C-X: ARG360C, GLU371X, THR373X, VAL364X
• G-H: ALA1040H, ALA1041H, ALA1046H, ALA1050H, ALA1052H, ALA1053H, ALA1055H, ALA341G, ALA526G, ALA529G, ALA540G, ALA543G, ARG1056H, ARG319G, ARG325G, ARG330G, ARG336G, ARG345G, ARG499G, ARG530G, ASN524G, ASN542G, ASP317G, ASP322G, ASP328G, ASP452G, GLN1058H, GLN525G, GLN539G, GLU320G, GLU538G, GLY1039H, GLY1042H, GLY1043H, GLY318G, GLY326G, GLY332G, GLY346G, GLY528G, GLY535G, HIS1044H, HIS1048H, HIS1049H, HIS532G, ILE324G, ILE464G, ILE533G, ILE541G, LEU327G, LEU334G, LEU342G, LEU351G, LEU448G, LEU531G, LEU534G, LYS321G, LYS527G, MET323G, MET466G, MET537G, PHE343G, PRO1054H, PRO1057H, PRO1059H, PRO335G, SER1051H, SER340G, SER479G, THR1045H, THR1047H, THR331G, THR337G, THR344G, VAL329G, VAL333G, VAL536G
• G-I: ALA115I, ALA24I, ALA268G, ALA27I, ALA29I, ALA30I, ALA341G, ALA350G, ALA354G, ALA359G, ALA362G, ALA39I, ALA69I, ALA70I, ARG25I, ARG266G, ARG330G, ARG336G, ARG345G, ARG360G, ARG405G, ARG426G, ARG66I, ARG72I, ARG79I, ARG80I, ARG83G, ARG83I, ASN109I, ASN121I, ASN381G, ASN3I, ASN435G, ASN62I, ASP262G, ASP271G, ASP328G, ASP361G, ASP366G, ASP36I, ASP374G, ASP37I, GLN112I, GLN123I, GLN264G, GLN26I, GLN349G, GLN363G, GLN47I, GLN64I, GLU110I, GLU19I, GLU265G, GLU276G, GLU347G, GLU367G, GLU371G, GLU371I, GLU389G, GLU400G, GLU430G, GLU433G, GLU81I, GLU86G, GLU88G, GLY21I, GLY339G, GLY346G, GLY357G, GLY388G, GLY391G, GLY394G, GLY402G, GLY404G, GLY46I, GLY71I, GLY75G, GLY75I, GLY82I, GLY87G, HIS338G, HIS379G, HIS403G, ILE114I, ILE273G, ILE401G, ILE431G, ILE73I, LEU2I, LEU327G, LEU334G, LEU342G, LEU351G, LEU356G, LEU365G, LEU368I, LEU377G, LYS228I, LYS263G, LYS274G, LYS397G, LYS48I, LYS49I, MET22I, MET23I, MET32I, MET35I, MET392G, PHE343G, PHE378G, PHE382G, PHE41I, PHE77I, PHE78I, PRO122I, PRO335G, PRO383G, PRO384G, PRO396G, PRO4I, PRO58I, PRO74I, PRO84G, PRO84I, SER119I, SER275G, SER340G, SER34I, SER386G, SER395G, SER429G, SER434G, SER76G, SER76I, SER85G, THR116I, THR28I, THR337G, THR344G, THR348G, THR353G, THR355G, THR358G, THR375G, THR38I, THR390G, THR424G, THR432G, THR43I, THR60I, THR67I, TYR267G, TYR380G, TYR385G, TYR63I, TYR68I, VAL111I, VAL113I, VAL117I, VAL118I, VAL120I, VAL124I, VAL272G, VAL329G, VAL333G, VAL352G, VAL364G, VAL387G, VAL393G, VAL425G, VAL427G, VAL428G, VAL42I, VAL44I, VAL45I
• G-K: ALA115G, ALA24G, ALA268K, ALA27G, ALA29G, ALA30G, ALA350K, ALA354K, ALA359K, ALA362K, ALA39G, ALA69G, ALA70G, ARG25G, ARG266K, ARG330K, ARG336K, ARG345K, ARG360K, ARG405K, ARG426K, ARG66G, ARG72G, ARG79G, ARG80G, ARG83G, ARG83K, ASN121G, ASN381K, ASN3G, ASN435K, ASN62G, ASP262K, ASP271K, ASP328K, ASP361K, ASP366K, ASP36G, ASP374K, ASP37G, GLN112G, GLN123G, GLN264K, GLN269K, GLN26G, GLN349K, GLN363K, GLN47G, GLN64G, GLU110G, GLU19G, GLU265K, GLU347K, GLU367K, GLU371K, GLU389K, GLU400K, GLU430K, GLU433K, GLU81G, GLU86K, GLY21G, GLY326K, GLY339K, GLY346K, GLY357K, GLY388K, GLY391K, GLY394K, GLY402K, GLY404K, GLY46G, GLY71G, GLY75G, GLY75K, GLY82G, GLY87K, HIS338K, HIS379K, ILE114G, ILE401K, ILE431K, ILE73G, LEU2G, LEU327K, LEU334K, LEU342K, LEU351K, LEU356K, LEU365K, LEU377K, LYS228G, LYS263K, LYS397K, LYS48G, LYS49G, MET22G, MET23G, MET32G, MET35G, MET392K, PHE378K, PHE382K, PHE41G, PHE77G, PHE78G, PRO122G, PRO335K, PRO383K, PRO384K, PRO396K, PRO4G, PRO74G, PRO84G, PRO84K, SER119G, SER275K, SER340K, SER34G, SER386K, SER395K, SER429K, SER434K, SER76G, SER76K, SER85K, THR116G, THR28G, THR337K, THR344K, THR348K, THR353K, THR355K, THR358K, THR373K, THR375K, THR38G, THR390K, THR424K, THR432K, THR43G, THR60G, THR67G, THR89K, TYR267K, TYR380K, TYR385K, TYR423K, TYR63G, TYR68G, VAL111G, VAL113G, VAL117G, VAL118G, VAL120G, VAL124G, VAL272K, VAL329K, VAL333K, VAL352K, VAL364K, VAL387K, VAL393K, VAL40G, VAL425K, VAL427K, VAL428K, VAL42G, VAL44G, VAL45G, VAL61G
• G-L: ALA1040L, ALA1041L, ALA1046L, ALA1050L, ALA1052L, ALA39G, ARG7G, ASN121G, ASN3G, ASP36G, ASP37G, GLU19G, GLY1039L, GLY1042L, GLY1043L, HIS1044L, HIS1049L, HIS14G, ILE5G, LEU18G, LEU2G, LYS8G, MET22G, MET23G, MET32G, MET35G, PHE41G, PRO4G, SER1051L, SER119G, SER34G, THR1045L, THR15G, THR17G, THR20G, THR38G, VAL118G, VAL16G, VAL33G, VAL40G, VAL6G
• G-M: ARG360G, ARG360M, ARG79G, ASP419M, GLU371M, PHE77G, PRO422M, VAL364M
• G-R: ALA359G, ALA359R, ALA362R, ARG360G, ARG360R, ASP361R, ASP417G, ASP419G, GLY357G, GLY357R, HIS338R, LEU356G, LEU356R, LYS420G, LYS420R, MET418G, PHE421G, PHE421R, PRO422G, PRO422R, PRO456G, THR358G, THR358R, THR424G, TYR423G, TYR423R
• H-I: ALA1040H, ALA1041H, ALA1046H, ALA39I, ARG7I, ASN3I, ASP36I, ASP37I, GLU19I, GLY1039H, GLY1042H, GLY1043H, HIS1044H, HIS1049H, ILE5I, LEU18I, LEU2I, LYS8I, MET22I, MET23I, MET32I, MET35I, PHE41I, PRO4I, SER1051H, SER119I, SER34I, THR1045H, THR15I, THR17I, THR38I, VAL118I, VAL16I, VAL33I, VAL40I, VAL6I
• I-J: ALA1040J, ALA1041J, ALA1046J, ALA1050J, ALA1052J, ALA1053J, ALA1055J, ALA341I, ALA526I, ALA529I, ALA540I, ALA543I, ARG1056J, ARG319I, ARG325I, ARG330I, ARG336I, ARG499I, ARG530I, ASN524I, ASP317I, ASP322I, ASP328I, ASP452I, ASP480I, GLN1058J, GLN349I, GLN525I, GLN539I, GLU320I, GLU538I, GLY1039J, GLY1042J, GLY1043J, GLY318I, GLY326I, GLY332I, GLY346I, GLY528I, GLY535I, HIS1044J, HIS1048J, HIS1049J, HIS532I, ILE324I, ILE464I, ILE533I, ILE541I, LEU327I, LEU334I, LEU342I, LEU351I, LEU448I, LEU531I, LEU534I, LYS321I, LYS527I, MET323I, MET466I, MET537I, PRO1054J, PRO1057J, PRO1059J, PRO335I, SER1051J, SER340I, SER479I, THR1045J, THR1047J, THR331I, THR344I, VAL329I, VAL333I, VAL536I
• I-K: ALA115K, ALA24K, ALA268I, ALA27K, ALA29K, ALA30K, ALA350I, ALA354I, ALA359I, ALA362I, ALA39K, ALA69K, ALA70K, ARG25K, ARG266I, ARG325I, ARG330I, ARG336I, ARG345I, ARG360I, ARG398K, ARG399I, ARG426I, ARG66K, ARG72K, ARG79K, ARG80K, ARG83I, ARG83K, ASN109K, ASN121K, ASN381I, ASN3K, ASN435I, ASN62K, ASP262I, ASP271I, ASP328I, ASP361I, ASP366I, ASP36K, ASP374I, ASP37K, GLN112K, GLN123K, GLN264I, GLN26K, GLN349I, GLN363I, GLN47K, GLN64K, GLU110K, GLU19K, GLU347I, GLU371I, GLU389I, GLU400I, GLU430I, GLU433I, GLU81K, GLU86I, GLY21K, GLY326I, GLY339I, GLY346I, GLY357I, GLY388I, GLY391I, GLY394I, GLY404I, GLY436I, GLY46K, GLY483I, GLY71K, GLY75I, GLY75K, GLY82K, GLY87I, HIS338I, HIS379I, HIS403I, ILE114K, ILE401I, ILE431I, ILE73K, LEU2K, LEU327I, LEU334I, LEU342I, LEU351I, LEU356I, LEU365I, LEU377I, LEU59K, LYS228K, LYS263I, LYS397I, LYS48K, LYS49K, MET1K, MET22K, MET23K, MET32K, MET392I, PHE343I, PHE378I, PHE382I, PHE41K, PHE77K, PHE78K, PRO122K, PRO335I, PRO383I, PRO384I, PRO396I, PRO4K, PRO58K, PRO74K, PRO84I, PRO84K, SER119K, SER275I, SER340I, SER34K, SER386I, SER395I, SER429I, SER434I, SER76K, SER85I, THR116K, THR28K, THR337I, THR344I, THR348I, THR353I, THR355I, THR358I, THR373I, THR375I, THR38K, THR390I, THR424I, THR432I, THR43K, THR60K, THR67K, THR89I, TYR267I, TYR380I, TYR385I, TYR423I, TYR68K, VAL111K, VAL113K, VAL117K, VAL118K, VAL120K, VAL272I, VAL329I, VAL333I, VAL352I, VAL364I, VAL387I, VAL393I, VAL425I, VAL427I, VAL428I, VAL42K, VAL44K, VAL45K
• I-M: ALA359I, ALA359M, ALA362I, ALA453M, ARG336M, ARG360I, ARG360M, ARG372I, ASP361I, ASP361M, ASP374I, GLN363I, GLU371I, GLY357M, GLY454M, HIS338M, LEU356M, LEU365I, LYS420I, PHE421I, PHE421M, PRO422I, PRO422M, THR355M, THR358I, THR358M, THR373I, THR424M, TYR423I, TYR423M, VAL364I, VAL425M
• I-O: ALA359I, ALA359O, ALA70O, ARG360I, ARG360O, ARG372O, ARG72O, ASN121O, ASN158I, ASP159I, ASP168I, ASP168O, ASP417I, ASP417O, ASP419I, ASP419O, GLN123I, GLN123O, GLN160I, GLN167O, GLN194I, GLU169I, GLU169O, GLU172I, GLU172O, GLU367O, GLU371O, GLY370O, GLY71O, ILE157I, ILE73O, LYS171I, LYS171O, LYS174I, LYS420I, LYS420O, LYS458I, MET369O, MET418I, MET418O, PHE421I, PHE421O, PRO122O, PRO416I, PRO422I, PRO422O, PRO456I, SER173I, THR166O, THR358I, THR358O, THR373I, THR373O, THR375O, TYR156I, TYR423I, VAL120O, VAL162I
• J-K: ALA1040J, ALA1041J, ALA1046J, ALA1050J, ALA1052J, ALA1053J, ALA39K, ARG7K, ASN3K, ASP36K, ASP37K, GLU19K, GLY1039J, GLY1042J, GLY1043J, HIS1044J, HIS1049J, ILE5K, LEU18K, LEU2K, LYS8K, MET1K, MET22K, MET23K, MET32K, MET35K, PHE41K, PRO1054J, PRO4K, SER1051J, SER119K, SER34K, THR1045J, THR15K, THR17K, THR20K, THR38K, VAL118K, VAL16K, VAL33K, VAL40K, VAL6K
• K-L: ALA1040L, ALA1041L, ALA1046L, ALA1050L, ALA1052L, ALA1053L, ALA1055L, ALA341K, ALA526K, ALA529K, ALA540K, ALA543K, ARG1056L, ARG315K, ARG319K, ARG325K, ARG330K, ARG336K, ARG345K, ARG499K, ARG530K, ASN524K, ASN542K, ASP317K, ASP322K, ASP328K, ASP452K, GLN1058L, GLN525K, GLN539K, GLU320K, GLU538K, GLY1039L, GLY1042L, GLY1043L, GLY326K, GLY332K, GLY346K, GLY528K, GLY535K, HIS1044L, HIS1048L, HIS1049L, HIS532K, ILE324K, ILE464K, ILE533K, ILE541K, LEU327K, LEU334K, LEU342K, LEU351K, LEU448K, LEU531K, LEU534K, LYS321K, LYS527K, MET323K, MET451K, MET466K, MET537K, PHE343K, PRO1054L, PRO1057L, PRO1059L, PRO335K, SER1051L, SER340K, SER479K, THR1045L, THR1047L, THR331K, THR344K, VAL329K, VAL333K, VAL536K
• K-M: ALA359K, ALA362K, ARG360K, ARG360M, ARG372K, ARG79K, ASP361K, ASP417M, ASP419M, GLN194M, GLN363K, GLU172M, GLU371K, GLY75K, ILE73K, LYS171M, LYS420M, LYS458M, MET418M, PHE421M, PHE77K, PRO422M, PRO456M, PRO74K, THR358K, THR358M, THR373K, TYR423M, VAL364K
• M-N: ALA1040N, ALA1041N, ALA1046N, ALA1050N, ALA1052N, ALA1053N, ALA1055N, ALA341M, ALA529M, ALA540M, ARG1056N, ARG319M, ARG325M, ARG330M, ARG336M, ARG345M, ARG499M, ARG530M, ASN524M, ASN542M, ASP317M, ASP322M, ASP328M, ASP452M, GLN1058N, GLN349M, GLN525M, GLN539M, GLU320M, GLU538M, GLY1039N, GLY1042N, GLY1043N, GLY318M, GLY326M, GLY332M, GLY346M, GLY528M, GLY535M, HIS1044N, HIS1048N, HIS1049N, HIS532M, ILE324M, ILE533M, ILE541M, LEU327M, LEU334M, LEU342M, LEU351M, LEU448M, LEU531M, LEU534M, LYS321M, LYS527M, MET323M, MET466M, MET537M, PRO1054N, PRO1057N, PRO1059N, PRO335M, SER1051N, SER340M, SER479M, THR1045N, THR1047N, THR331M, THR344M, VAL329M, VAL333M, VAL536M
• M-O: ALA115O, ALA24O, ALA268M, ALA27O, ALA29O, ALA30O, ALA350M, ALA354M, ALA359M, ALA362M, ALA39O, ALA69O, ALA70O, ARG25O, ARG266M, ARG330M, ARG336M, ARG345M, ARG360M, ARG398O, ARG405M, ARG426M, ARG66O, ARG72O, ARG79O, ARG80O, ARG83M, ARG83O, ASN109O, ASN121O, ASN381M, ASN3O, ASN435M, ASN62O, ASP262M, ASP271M, ASP328M, ASP361M, ASP366M, ASP36O, ASP374M, ASP37O, GLN112O, GLN123O, GLN264M, GLN26O, GLN349M, GLN363M, GLN47O, GLN64O, GLU110O, GLU19O, GLU276M, GLU347M, GLU371M, GLU389M, GLU400M, GLU430M, GLU433M, GLU65O, GLU81O, GLU86M, GLY21O, GLY326M, GLY339M, GLY346M, GLY357M, GLY388M, GLY391M, GLY394M, GLY402M, GLY404M, GLY46O, GLY483M, GLY71O, GLY75M, GLY75O, GLY82O, GLY87M, HIS338M, HIS379M, HIS403M, ILE114O, ILE401M, ILE431M, ILE73O, LEU2O, LEU327M, LEU334M, LEU342M, LEU351M, LEU356M, LEU365M, LEU377M, LYS228O, LYS263M, LYS397M, LYS48O, LYS49O, MET1O, MET22O, MET23O, MET32O, MET392M, PHE343M, PHE378M, PHE382M, PHE41O, PHE77O, PHE78O, PRO122O, PRO335M, PRO383M, PRO384M, PRO396M, PRO4O, PRO58O, PRO74O, PRO84M, PRO84O, SER119O, SER275M, SER340M, SER34O, SER386M, SER395M, SER429M, SER434M, SER76M, SER76O, SER85M, THR116O, THR28O, THR337M, THR344M, THR348M, THR353M, THR355M, THR358M, THR375M, THR38O, THR390M, THR424M, THR432M, THR43O, THR60O, THR67O, TYR267M, TYR380M, TYR385M, TYR423M, TYR63O, TYR68O, VAL111O, VAL113O, VAL117O, VAL118O, VAL120O, VAL124O, VAL272M, VAL329M, VAL333M, VAL352M, VAL364M, VAL387M, VAL393M, VAL425M, VAL427M, VAL428M, VAL42O, VAL44O, VAL45O
• M-R: ALA115M, ALA24M, ALA268R, ALA27M, ALA29M, ALA30M, ALA341R, ALA354R, ALA359R, ALA362R, ALA39M, ALA69M, ALA70M, ARG25M, ARG266R, ARG330R, ARG336R, ARG345R, ARG360R, ARG398M, ARG405R, ARG426R, ARG66M, ARG72M, ARG79M, ARG80M, ARG83M, ARG83R, ASN121M, ASN381R, ASN3M, ASN435R, ASN62M, ASP262R, ASP271R, ASP328R, ASP361R, ASP366R, ASP36M, ASP374R, ASP37M, GLN112M, GLN123M, GLN264R, GLN26M, GLN349R, GLN363R, GLN47M, GLN64M, GLU110M, GLU19M, GLU265R, GLU347R, GLU367R, GLU371R, GLU389R, GLU400R, GLU430R, GLU433R, GLU81M, GLU86R, GLU88R, GLY21M, GLY326R, GLY339R, GLY346R, GLY357R, GLY388R, GLY391R, GLY394R, GLY402R, GLY404R, GLY436R, GLY46M, GLY71M, GLY75M, GLY75R, GLY82M, GLY87R, HIS338R, HIS379R, ILE114M, ILE401R, ILE431R, ILE73M, LEU2M, LEU327R, LEU334R, LEU342R, LEU351R, LEU356R, LEU365R, LEU368M, LEU377R, LYS228M, LYS263R, LYS397R, LYS408R, LYS48M, LYS49M, MET1M, MET22M, MET23M, MET32M, MET35M, MET392R, PHE378R, PHE382R, PHE41M, PHE77M, PHE78M, PRO122M, PRO335R, PRO383R, PRO384R, PRO396R, PRO4M, PRO58M, PRO74M, PRO84M, PRO84R, SER119M, SER275R, SER340R, SER34M, SER386R, SER395R, SER429R, SER434R, SER76M, SER85R, THR116M, THR28M, THR337R, THR344R, THR348R, THR353R, THR355R, THR358R, THR373R, THR375R, THR38M, THR390R, THR424R, THR432R, THR43M, THR60M, THR67M, TYR267R, TYR380R, TYR385R, TYR423R, TYR68M, VAL111M, VAL113M, VAL117M, VAL118M, VAL120M, VAL124M, VAL272R, VAL333R, VAL352R, VAL364R, VAL387R, VAL393R, VAL425R, VAL427R, VAL428R, VAL42M, VAL44M, VAL45M, VAL6M
• M-S: ALA1040S, ALA1041S, ALA1046S, ALA1052S, ALA1053S, ALA39M, ARG7M, ASN3M, ASP36M, ASP37M, GLU19M, GLY1039S, GLY1042S, GLY1043S, HIS1044S, HIS1049S, ILE5M, LEU18M, LEU2M, LYS8M, MET1M, MET22M, MET23M, MET32M, MET35M, PHE41M, PRO1054S, PRO4M, SER1051S, SER119M, SER34M, THR1045S, THR15M, THR17M, THR20M, THR38M, VAL118M, VAL16M, VAL33M, VAL40M, VAL6M
• N-O: ALA1040N, ALA1041N, ALA1046N, ALA1052N, ALA1053N, ALA39O, ARG7O, ASN3O, ASP36O, ASP37O, GLU19O, GLY1039N, GLY1042N, GLY1043N, HIS1044N, HIS1049N, ILE5O, LEU18O, LEU2O, LYS8O, MET1O, MET22O, MET23O, MET32O, MET35O, PHE41O, PRO1054N, PRO4O, SER1051N, SER119O, SER34O, THR1045N, THR15O, THR17O, THR20O, THR38O, VAL118O, VAL129O, VAL16O, VAL33O, VAL40O, VAL6O
• O-P: ALA1040P, ALA1041P, ALA1046P, ALA1050P, ALA1052P, ALA1053P, ALA1055P, ALA341O, ALA526O, ALA529O, ALA540O, ALA543O, ARG1056P, ARG319O, ARG325O, ARG330O, ARG336O, ARG345O, ARG499O, ARG530O, ASN524O, ASN542O, ASP317O, ASP322O, ASP328O, ASP452O, GLN1058P, GLN525O, GLN539O, GLU320O, GLU538O, GLY1039P, GLY1042P, GLY1043P, GLY318O, GLY326O, GLY332O, GLY346O, GLY528O, GLY535O, HIS1044P, HIS1048P, HIS1049P, HIS532O, ILE324O, ILE464O, ILE533O, ILE541O, LEU327O, LEU334O, LEU342O, LEU351O, LEU448O, LEU531O, LEU534O, LYS321O, LYS527O, MET323O, MET466O, MET537O, PHE343O, PRO1054P, PRO1057P, PRO1059P, PRO335O, SER1051P, SER340O, SER479O, THR1045P, THR1047P, THR331O, THR344O, VAL329O, VAL333O, VAL536O
• O-R: ALA115R, ALA24R, ALA268O, ALA27R, ALA29R, ALA30R, ALA354O, ALA359O, ALA362O, ALA39R, ALA69R, ALA70R, ARG25R, ARG266O, ARG325O, ARG330O, ARG336O, ARG345O, ARG360O, ARG398O, ARG398R, ARG405O, ARG426O, ARG66R, ARG72R, ARG79R, ARG80R, ARG83O, ARG83R, ASN109R, ASN121R, ASN381O, ASN3R, ASN435O, ASN62R, ASP262O, ASP271O, ASP328O, ASP361O, ASP366O, ASP36R, ASP374O, ASP37R, GLN112R, GLN123R, GLN264O, GLN26R, GLN349O, GLN363O, GLN47R, GLN64R, GLU110R, GLU19R, GLU347O, GLU367O, GLU389O, GLU400O, GLU430O, GLU433O, GLU81R, GLU86O, GLY21R, GLY326O, GLY339O, GLY346O, GLY357O, GLY388O, GLY391O, GLY394O, GLY402O, GLY404O, GLY46R, GLY71R, GLY75O, GLY75R, GLY82O, GLY82R, GLY87O, HIS338O, HIS379O, ILE114R, ILE401O, ILE431O, ILE73R, LEU2R, LEU327O, LEU334O, LEU342O, LEU351O, LEU356O, LEU365O, LEU377O, LYS228R, LYS263O, LYS397O, LYS48R, LYS49R, MET1R, MET22R, MET23R, MET32R, MET392O, PHE343O, PHE378O, PHE382O, PHE41R, PHE77R, PHE78R, PRO122R, PRO335O, PRO383O, PRO384O, PRO396O, PRO4R, PRO58R, PRO74R, PRO84O, PRO84R, SER119R, SER275O, SER340O, SER34R, SER386O, SER395O, SER429O, SER434O, SER76O, SER76R, SER85O, THR116R, THR28R, THR337O, THR344O, THR348O, THR353O, THR355O, THR358O, THR373O, THR375O, THR38R, THR390O, THR424O, THR432O, THR43R, THR60R, THR67R, THR89O, TYR267O, TYR380O, TYR385O, TYR423O, TYR68R, VAL111R, VAL113R, VAL117R, VAL118R, VAL120R, VAL124R, VAL272O, VAL329O, VAL333O, VAL352O, VAL364O, VAL387O, VAL393O, VAL425O, VAL427O, VAL428O, VAL42R, VAL44R, VAL45R
• P-R: ALA1040P, ALA1041P, ALA1046P, ALA1050P, ALA1052P, ALA1053P, ALA39R, ARG7R, ASN3R, ASP36R, ASP37R, GLU19R, GLY1039P, GLY1042P, GLY1043P, HIS1044P, HIS1049P, ILE5R, LEU18R, LEU2R, LYS8R, MET1R, MET22R, MET23R, MET32R, MET35R, PHE41R, PRO1054P, PRO4R, SER1051P, SER119R, SER34R, THR1045P, THR15R, THR17R, THR38R, VAL118R, VAL129R, VAL16R, VAL33R, VAL40R, VAL6R
• R-S: ALA1040S, ALA1041S, ALA1046S, ALA1050S, ALA1052S, ALA1053S, ALA1055S, ALA341R, ALA526R, ALA529R, ALA540R, ALA543R, ARG1056S, ARG319R, ARG325R, ARG330R, ARG336R, ARG345R, ARG499R, ARG530R, ASN524R, ASN542R, ASP317R, ASP322R, ASP328R, ASP452R, GLN1058S, GLN349R, GLN525R, GLN539R, GLU320R, GLU538R, GLY1039S, GLY1042S, GLY1043S, GLY326R, GLY332R, GLY346R, GLY528R, GLY535R, HIS1044S, HIS1048S, HIS1049S, HIS532R, ILE324R, ILE533R, ILE541R, LEU327R, LEU334R, LEU342R, LEU351R, LEU448R, LEU531R, LYS321R, LYS527R, MET323R, MET451R, MET466R, MET537R, PRO1054S, PRO1057S, PRO1059S, PRO335R, SER1051S, SER340R, SER479R, THR1045S, THR1047S, THR331R, THR344R, VAL329R, VAL333R, VAL536R
• T-U: ALA1040U, ALA1041U, ALA1046U, ALA1050U, ALA1052U, ALA1053U, ALA1055U, ALA341T, ALA526T, ALA529T, ALA540T, ALA543T, ARG1056U, ARG319T, ARG325T, ARG330T, ARG336T, ARG345T, ARG499T, ARG530T, ASN524T, ASN542T, ASP317T, ASP322T, ASP328T, ASP452T, GLN1058U, GLN349T, GLN525T, GLN539T, GLU320T, GLU538T, GLY1039U, GLY1042U, GLY1043U, GLY326T, GLY332T, GLY346T, GLY528T, GLY535T, HIS1044U, HIS1048U, HIS1049U, HIS532T, ILE324T, ILE464T, ILE533T, ILE541T, LEU327T, LEU334T, LEU342T, LEU351T, LEU448T, LEU531T, LYS321T, LYS527T, MET323T, MET466T, MET537T, PHE343T, PRO1054U, PRO1057U, PRO1059U, PRO335T, SER1051U, SER340T, SER479T, THR1045U, THR1047U, THR331T, THR344T, VAL329T, VAL333T, VAL536T
• T-V: ALA115V, ALA24V, ALA268T, ALA27V, ALA29V, ALA30V, ALA350T, ALA354T, ALA359T, ALA362T, ALA39V, ALA69V, ALA70V, ARG25V, ARG266T, ARG325T, ARG330T, ARG336T, ARG345T, ARG360T, ARG398V, ARG426T, ARG66V, ARG72V, ARG79V, ARG80V, ARG83T, ARG83V, ASN121V, ASN381T, ASN3V, ASN435T, ASN62V, ASP262T, ASP271T, ASP328T, ASP361T, ASP366T, ASP36V, ASP374T, ASP37V, GLN112V, GLN123V, GLN264T, GLN26V, GLN349T, GLN363T, GLN47V, GLN64V, GLU110V, GLU19V, GLU347T, GLU389T, GLU400T, GLU430T, GLU433T, GLU81V, GLU86T, GLY21V, GLY326T, GLY339T, GLY346T, GLY357T, GLY388T, GLY391T, GLY394T, GLY404T, GLY436T, GLY46V, GLY483T, GLY71V, GLY75T, GLY75V, GLY82T, GLY82V, GLY87T, HIS338T, HIS379T, HIS403T, ILE114V, ILE401T, ILE431T, ILE73V, LEU2V, LEU327T, LEU334T, LEU342T, LEU351T, LEU356T, LEU365T, LEU377T, LYS228V, LYS263T, LYS397T, LYS48V, LYS49V, MET1V, MET22V, MET23V, MET32V, MET35V, MET392T, PHE343T, PHE376T, PHE378T, PHE382T, PHE41V, PHE77V, PHE78V, PRO122V, PRO335T, PRO383T, PRO384T, PRO396T, PRO4V, PRO58V, PRO74V, PRO84T, PRO84V, SER119V, SER275T, SER340T, SER34V, SER386T, SER395T, SER429T, SER434T, SER76V, SER85T, THR116V, THR28V, THR337T, THR344T, THR348T, THR353T, THR355T, THR358T, THR375T, THR38V, THR390T, THR424T, THR432T, THR43V, THR60V, THR67V, TYR267T, TYR380T, TYR385T, TYR423T, TYR68V, VAL111V, VAL113V, VAL117V, VAL118V, VAL120V, VAL124V, VAL272T, VAL329T, VAL333T, VAL352T, VAL364T, VAL387T, VAL393T, VAL425T, VAL427T, VAL428T, VAL42V, VAL44V, VAL45V
• T-X: ALA115T, ALA24T, ALA268X, ALA27T, ALA29T, ALA30T, ALA341X, ALA354X, ALA359X, ALA362X, ALA39T, ALA69T, ALA70T, ARG25T, ARG266X, ARG325X, ARG330X, ARG336X, ARG345X, ARG360X, ARG398T, ARG405X, ARG426X, ARG66T, ARG72T, ARG79T, ARG80T, ARG83T, ARG83X, ASN121T, ASN381X, ASN3T, ASN62T, ASP262X, ASP271X, ASP328X, ASP361X, ASP366X, ASP36T, ASP374X, ASP37T, GLN112T, GLN123T, GLN264X, GLN26T, GLN349X, GLN363X, GLN47T, GLN64T, GLU110T, GLU19T, GLU347X, GLU371X, GLU389X, GLU400X, GLU430X, GLU81T, GLU86X, GLU88X, GLY21T, GLY339X, GLY346X, GLY357X, GLY388X, GLY391X, GLY394X, GLY402X, GLY404X, GLY46T, GLY71T, GLY75T, GLY75X, GLY82T, GLY87X, HIS338X, HIS379X, HIS403X, ILE114T, ILE401X, ILE73T, LEU2T, LEU327X, LEU334X, LEU342X, LEU351X, LEU356X, LEU365X, LEU377X, LYS228T, LYS263X, LYS397X, LYS48T, LYS49T, MET22T, MET23T, MET32T, MET35T, MET392X, PHE376X, PHE378X, PHE382X, PHE41T, PHE77T, PHE78T, PRO122T, PRO335X, PRO383X, PRO384X, PRO396X, PRO4T, PRO58T, PRO74T, PRO84T, PRO84X, SER119T, SER275X, SER340X, SER34T, SER386X, SER395X, SER434X, SER76T, SER76X, SER85X, THR116T, THR28T, THR337X, THR344X, THR348X, THR353X, THR355X, THR358X, THR373X, THR375X, THR38T, THR390X, THR43T, THR60T, THR67T, TYR267X, TYR380X, TYR385X, TYR63T, TYR68T, VAL111T, VAL113T, VAL117T, VAL118T, VAL120T, VAL124T, VAL329X, VAL333X, VAL352X, VAL364X, VAL387X, VAL393X, VAL44T, VAL45T, VAL61T
• T-Y: GLU19T, GLY1043Y, HIS1044Y
• U-V: ALA1040U, ALA1041U, ALA1046U, ALA1050U, ALA1052U, ALA1053U, ALA39V, ARG7V, ASN121V, ASN3V, ASP36V, ASP37V, GLU19V, GLY1039U, GLY1042U, GLY1043U, HIS1044U, HIS1049U, HIS14V, ILE5V, LEU18V, LEU2V, LYS8V, MET1V, MET22V, MET23V, MET32V, MET35V, PHE41V, PRO1054U, PRO4V, SER1051U, SER119V, SER34V, THR1045U, THR15V, THR17V, THR38V, VAL118V, VAL129V, VAL16V, VAL33V, VAL40V, VAL6V
• V-W: ALA1040W, ALA1041W, ALA1046W, ALA1050W, ALA1052W, ALA1053W, ALA1055W, ALA341V, ALA526V, ALA529V, ALA540V, ALA543V, ARG1056W, ARG319V, ARG325V, ARG330V, ARG336V, ARG345V, ARG499V, ARG530V, ASN524V, ASN542V, ASP317V, ASP322V, ASP328V, ASP452V, GLN1058W, GLN525V, GLN539V, GLU320V, GLU538V, GLY1039W, GLY1042W, GLY1043W, GLY318V, GLY326V, GLY332V, GLY346V, GLY528V, GLY535V, HIS1044W, HIS1048W, HIS1049W, HIS532V, ILE324V, ILE464V, ILE533V, ILE541V, LEU327V, LEU334V, LEU342V, LEU351V, LEU448V, LEU531V, LYS321V, LYS527V, MET323V, MET451V, MET466V, MET537V, PRO1054W, PRO1057W, PRO1059W, PRO335V, PRO544V, SER1051W, SER340V, SER479V, THR1045W, THR1047W, THR331V, THR344V, VAL329V, VAL333V, VAL536V
• V-X: ALA115X, ALA24X, ALA268V, ALA27X, ALA29X, ALA30X, ALA350V, ALA354V, ALA359V, ALA362V, ALA39X, ALA69X, ALA70X, ARG25X, ARG266V, ARG330V, ARG336V, ARG345V, ARG360V, ARG398X, ARG426V, ARG66X, ARG72X, ARG79X, ARG80X, ARG83V, ARG83X, ASN121X, ASN381V, ASN3X, ASN435V, ASN62X, ASP262V, ASP271V, ASP328V, ASP361V, ASP366V, ASP36X, ASP374V, ASP37X, GLN112X, GLN123X, GLN264V, GLN26X, GLN349V, GLN363V, GLN47X, GLN64X, GLU110X, GLU19X, GLU265V, GLU347V, GLU367V, GLU371X, GLU389V, GLU400V, GLU430V, GLU433V, GLU81X, GLU86V, GLU88V, GLY326V, GLY339V, GLY346V, GLY357V, GLY388V, GLY391V, GLY394V, GLY404V, GLY46X, GLY483V, GLY71X, GLY75V, GLY75X, GLY82X, GLY87V, HIS338V, HIS379V, ILE114X, ILE401V, ILE431V, ILE73X, LEU2X, LEU327V, LEU334V, LEU342V, LEU351V, LEU356V, LEU365V, LEU377V, LYS228X, LYS263V, LYS397V, LYS48X, LYS49X, MET1X, MET22X, MET23X, MET32X, MET35X, MET392V, PHE378V, PHE382V, PHE41X, PHE77X, PHE78X, PRO122X, PRO335V, PRO383V, PRO384V, PRO396V, PRO4X, PRO58X, PRO74X, PRO84V, PRO84X, SER119X, SER275V, SER340V, SER34X, SER386V, SER395V, SER429V, SER434V, SER76V, SER76X, SER85V, THR116X, THR28X, THR337V, THR344V, THR348V, THR353V, THR355V, THR358V, THR375V, THR38X, THR390V, THR424V, THR432V, THR43X, THR60X, THR67X, THR89V, TYR267V, TYR380V, TYR385V, TYR423V, TYR68X, VAL111X, VAL113X, VAL117X, VAL118X, VAL120X, VAL124X, VAL272V, VAL329V, VAL333V, VAL352V, VAL364V, VAL387V, VAL393V, VAL40X, VAL425V, VAL427V, VAL428V, VAL42X, VAL44X, VAL45X
• W-X: ALA1040W, ALA1041W, ALA1046W, ALA1050W, ALA1052W, ALA1053W, ALA39X, ASN3X, ASP36X, ASP37X, GLN10X, GLU19X, GLY1039W, GLY1042W, GLY1043W, HIS1044W, LEU18X, LEU2X, LYS8X, MET1X, MET22X, MET23X, MET32X, MET35X, PHE41X, PRO1054W, PRO4X, SER1051W, SER119X, SER34X, THR1045W, THR15X, THR17X, THR20X, THR38X, VAL118X, VAL16X, VAL33X, VAL40X, VAL6X
• X-Y: ALA1050Y, ALA1052Y, ALA1055Y, ARG1056Y, ARG330X, ASP322X, ASP328X, ASP452X, GLU320X, HIS1044Y, HIS1048Y, HIS1049Y, ILE324X, LEU327X, LYS321X, THR1047Y, THR331X, VAL329X