3H0L

structure of trna-dependent amidotransferase gatcab from aquifex aeolicus

• Total interactions analyzed: 276
• Total true interactions: 46
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 139
  • Norm. En. per Res.: -5.9499
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-45.0265	-17.7297	-375.734	-438.4902	133	20	7	15646	2	21	30
A-C	-74.8283	-18.9279	-680.354	-774.1102	209	24	22	28212	3	85	65
A-E	-16.5415	-28.2486	-80.4062	-125.1963	88	2	0	4336	3	54	51
A-G	0.0	0.0	-0.0677	-0.0677	7	0	0	32	0	7	6
B-C	-151.9326	-87.4807	-548.063	-787.4763	141	36	10	20205	9	59	50
B-G	0.0	0.0	-2.1945	-2.1945	10	0	0	221	0	9	8
B-S	0.0	2.9802	-2.6738	0.3065	9	0	0	234	0	9	8
C-E	0.0	0.0	-0.7391	-0.7391	6	0	0	124	0	6	6
C-G	-12.2655	-8.2618	-30.0479	-50.5752	28	1	0	1467	1	15	16
D-E	-50.2735	-8.5554	-388.015	-446.8439	134	17	7	15661	1	21	30
D-F	-98.8559	-30.5138	-692.35	-821.7197	209	26	22	28478	4	85	66
D-H	-8.1116	-32.9998	-53.0024	-94.1138	57	7	0	3008	5	47	46
E-F	-161.4655	-108.7572	-556.817	-827.0397	139	38	11	20509	12	59	51
E-G	-20.0524	-44.6559	-47.6661	-112.3745	60	7	0	3215	5	46	44
E-I	-7.9984	-37.6179	-41.526	-87.1422	36	4	0	2041	2	28	19
F-H	-12.5428	-39.2714	-42.4228	-94.2371	35	2	0	2077	2	28	21
G-H	-68.6582	-16.2356	-384.6	-469.4938	136	21	7	15764	2	23	30
G-I	-89.8227	-37.8525	-688.366	-816.0413	206	29	22	28713	6	86	66
G-K	-19.8852	-33.5431	-79.4613	-132.8896	90	3	0	4403	5	59	49
H-I	-165.2875	-84.4004	-546.334	-796.0219	139	37	10	20365	7	59	51
H-M	0.0	0.0	-0.0345	-0.0345	3	0	0	9	0	2	2
I-K	0.0	0.0	-0.0896	-0.0896	5	0	0	37	0	4	4
I-T	0.0	35.8329			4
J-K	-58.3117	-14.5533	-380.379	-453.2441	136	17	7	15561	2	21	29
J-L	-95.9309	-27.5142	-668.865	-792.31	208	19	22	28099	5	85	66
J-Q	0.0	-23.0346	-19.2095	-42.2441	24	0	0	738	1	16	15
K-L	-146.7741	-90.6385	-537.327	-774.7395	138	31	10	19960	9	58	48
K-N	-8.1152	12.1375	-11.7953	-7.7729	33	0	0	888	0	26	29
M-N	-64.4027	-15.5514	-372.52	-452.4741	135	17	7	15611	1	22	32
M-O	-92.1709	-25.1016	-684.931	-802.2035	208	26	22	28558	5	86	67
N-O	-168.5914	-83.9659	-539.672	-792.2293	138	43	10	20311	7	59	52
N-P	-22.4457	-41.317	-82.6067	-146.3694	95	4	0	4670	5	56	52
N-R	0.0	0.0	-0.6969	-0.6969	6	0	0	113	0	5	6
O-V	-7.3294	-6.5612			9
P-Q	-63.1756	-13.7656	-377.768	-454.7092	135	14	7	15457	1	22	29
P-R	-75.3476	-24.672	-656.197	-756.2166	209	23	22	28162	4	87	66
P-S	0.0	0.0	-0.1007	-0.1007	6	0	0	40	0	6	6
P-U	-10.072	-11.3345			9
Q-R	-162.1098	-90.9393	-535.555	-788.6041	138	41	10	20236	8	59	50
S-T	-52.8876	-13.4696			22
S-U	-83.8342	-24.0874			41
T-U	-163.7704	-95.5698			43
T-V	-21.1853	-29.7454			20
V-W	-61.7254	-15.3814			22
V-X	-86.9102	-17.5069			39
W-X	-154.1947	-90.7486			41

Interface residues

• A-B: ALA147B, ALA198A, ALA200A, ALA310A, ALA315A, ALA358A, ALA361A, ALA49B, ALA94A, ALA98A, ARG193A, ARG271B, ARG316A, ARG321A, ARG325A, ARG340A, ARG375A, ARG80B, ASN133B, ASN313A, ASN36B, ASN74A, ASP138B, ASP204A, ASP227A, ASP230A, ASP269B, ASP275B, ASP277B, ASP318A, ASP87B, CYS25B, CYS40B, CYS43B, CYS84A, GLN372A, GLU228A, GLU265B, GLU268B, GLU309A, GLU98B, GLY195A, GLY323A, GLY355A, GLY362A, GLY45B, GLY48B, GLY91B, HIS82B, ILE206A, ILE305A, ILE332A, ILE352A, ILE52B, ILE75A, ILE88A, ILE94B, LEU144B, LEU196A, LEU203A, LEU278B, LEU314A, LEU359A, LEU369A, LEU44B, LEU50B, LEU76A, LEU88B, LEU89A, LYS139B, LYS229A, LYS81B, LYS90B, LYS99B, MET335A, MET46B, PHE120A, PHE199A, PHE24B, PHE273B, PHE333A, PHE344A, PHE357A, PHE84B, PHE92A, PRO274B, PRO276B, PRO41B, PRO47B, PRO51B, PRO86B, PRO89B, PRO95A, SER192A, SER201A, SER202A, SER231A, SER233A, SER308A, SER311A, SER312A, SER360A, THR140B, THR232A, THR356A, THR82A, THR99A, TRP226A, TYR188A, TYR194A, TYR270B, TYR272B, TYR317A, TYR322A, TYR329A, TYR336A, TYR363A, TYR364A, TYR368A, TYR83B, TYR85B, TYR92B, TYR96A, TYR97B, VAL142B, VAL191A, VAL197A, VAL279B, VAL320A, VAL39B, VAL42B, VAL53B, VAL93A
• A-C: ALA11C, ALA14C, ALA234A, ALA315A, ALA326A, ALA337A, ALA358A, ALA361A, ALA366A, ALA371A, ALA424A, ALA427A, ALA74C, ALA78C, ALA94A, ARG15C, ARG193A, ARG321A, ARG325A, ARG338A, ARG340A, ARG350A, ARG351A, ARG375A, ARG376A, ARG4C, ARG61C, ARG81C, ARG90C, ASN380A, ASN410A, ASN425A, ASN47C, ASN77C, ASN91A, ASP227A, ASP230A, ASP318A, ASP32C, ASP331A, ASP341A, ASP35C, ASP365A, ASP38C, ASP418A, ASP44C, ASP70C, ASP97A, GLN205A, GLN27C, GLN29C, GLN372A, GLN39C, GLN53C, GLU17C, GLU228A, GLU22C, GLU328A, GLU334A, GLU342A, GLU347A, GLU409A, GLU413A, GLU42C, GLU46C, GLU49C, GLU54C, GLU56C, GLU57C, GLU72C, GLU78A, GLU80C, GLU90A, GLY189A, GLY319A, GLY323A, GLY343A, GLY345A, GLY355A, GLY428A, GLY79A, HIS294A, HIS452A, HIS66C, ILE10C, ILE23C, ILE299A, ILE304A, ILE305A, ILE332A, ILE33C, ILE352A, ILE378A, ILE37C, ILE412A, ILE419A, ILE52C, ILE88A, LEU13C, LEU16C, LEU18C, LEU203A, LEU30C, LEU314A, LEU34C, LEU354A, LEU359A, LEU369A, LEU377A, LEU383A, LEU408A, LEU40C, LEU416A, LEU426A, LEU429A, LEU43C, LEU69C, LEU75C, LEU76A, LEU89A, LEU8C, LYS12C, LYS19C, LYS229A, LYS235A, LYS28C, LYS296A, LYS330A, LYS349A, LYS370A, LYS373A, LYS41C, LYS73C, LYS81A, LYS9C, MET335A, MET353A, MET60C, MET76C, PHE26C, PHE333A, PHE344A, PHE357A, PHE36C, PHE55C, PHE86C, PHE92A, PRO293A, PRO300A, PRO307A, PRO346A, PRO411A, PRO50C, PRO59C, PRO79C, PRO89C, PRO95A, SER201A, SER202A, SER231A, SER233A, SER298A, SER311A, SER31C, SER360A, SER417A, THR187A, THR232A, THR301A, THR339A, THR356A, THR379A, THR45C, THR58C, THR82A, TRP226A, TRP453A, TRP6C, TYR128A, TYR188A, TYR194A, TYR297A, TYR302A, TYR303A, TYR317A, TYR322A, TYR324A, TYR329A, TYR336A, TYR363A, TYR364A, TYR367A, TYR368A, TYR415A, TYR51C, TYR96A, VAL25C, VAL295A, VAL2C, VAL320A, VAL348A, VAL374A, VAL48C, VAL7C, VAL87C, VAL88C, VAL91C, VAL92C, VAL93A
• A-E: ALA130A, ARG142A, ARG167E, ARG221E, ARG356E, ARG407A, ASN113E, ASN33A, ASN345E, ASN349E, ASP30A, ASP350E, ASP357E, GLN224E, GLU115E, GLU127A, GLU141A, GLU164E, GLU228E, GLU232E, GLU23A, GLU26A, GLU314E, GLU316E, GLU36A, GLU37A, GLU391E, GLU3E, GLU406A, GLU409A, GLU55A, GLU80A, GLU90A, GLY114E, GLY311E, GLY353E, GLY389E, GLY405A, GLY48A, ILE307E, ILE319E, ILE348E, ILE384E, ILE388E, LEU140A, LEU312E, LEU351E, LEU352E, LEU354E, LEU408A, LEU46A, LYS135A, LYS203E, LYS225E, LYS22A, LYS308E, LYS327A, LYS341E, LYS387E, LYS38A, LYS390E, LYS394E, LYS403A, LYS40A, LYS49A, LYS4E, LYS52A, LYS58A, LYS81A, LYS87A, PHE131A, PHE132A, PHE402A, PHE404A, PRO112E, PRO133A, PRO45A, SER313E, SER385E, SER56A, THR162E, THR386E, THR44A, TRP346E, TYR29A, TYR315E, TYR32A, VAL143A
• A-G: ARG325A, GLU281G, GLU328A, LYS278G, LYS282G, LYS327A, TYR329A
• B-C: ALA11C, ALA14C, ALA267B, ALA33B, ALA57B, ALA74C, ALA78C, ARG15C, ARG262B, ARG271B, ARG56B, ARG61C, ARG71C, ARG81C, ARG90C, ASN133B, ASN145B, ASN36B, ASN38B, ASN54B, ASN77C, ASP138B, ASP143B, ASP18B, ASP269B, ASP275B, ASP277B, ASP63C, ASP70C, ASP83C, ASP87B, CYS25B, CYS27B, CYS40B, CYS43B, GLN53C, GLU136B, GLU265B, GLU266B, GLU268B, GLU34B, GLU49C, GLU54C, GLU56C, GLU57C, GLU59B, GLU62C, GLU64C, GLU72C, GLU74B, GLU75B, GLU80C, GLU98B, GLY137B, GLY148B, GLY26B, GLY84C, HIS135B, HIS66C, HIS82B, ILE10C, ILE134B, ILE52B, ILE52C, ILE62B, LEU13C, LEU141B, LEU144B, LEU16C, LEU278B, LEU281B, LEU44B, LEU69C, LEU75C, LYS12C, LYS132B, LYS139B, LYS20B, LYS22B, LYS282B, LYS284B, LYS28B, LYS55B, LYS73C, LYS82C, LYS99B, LYS9C, MET17B, MET23B, MET261B, MET46B, MET60C, MET76C, PHE24B, PHE55C, PHE78B, PHE84B, PHE85C, PHE86C, PRO150B, PRO274B, PRO276B, PRO280B, PRO35B, PRO41B, PRO47B, PRO50C, PRO51B, PRO59C, PRO65C, PRO67C, PRO86B, PRO89B, PRO89C, SER68C, SER76B, THR140B, THR19B, THR21B, THR263B, THR37B, THR58C, TRP287B, TYR270B, TYR51C, TYR60B, TYR83B, TYR85B, VAL142B, VAL279B, VAL283B, VAL29B, VAL39B, VAL42B, VAL53B, VAL58B, VAL77B, VAL87C, VAL88C, VAL91C, VAL92C
• B-G: ASN275G, ASP138B, GLU136B, GLU279G, LEU141B, LYS139B, LYS278G, LYS282G, LYS439G, LYS468G
• B-S: ARG16S, ARG60S, ASN294B, GLU18S, GLU290B, GLU61S, GLY17S, LYS15S, LYS293B
• C-E: GLN29C, GLU21C, GLU24C, LYS380E, LYS382E, VAL25C
• C-G: ALA272G, ALA437G, ALA78C, ARG71C, ARG81C, ASN275G, ASP440G, ASP83C, GLN268G, GLU271G, GLU274G, GLU279G, GLU72C, GLU80C, GLY441G, GLY84C, LEU75C, LYS270G, LYS278G, LYS282G, LYS439G, LYS82C, PHE85C, PRO267G, PRO79C, PRO89C, TRP438G, VAL87C
• D-E: ALA147E, ALA198D, ALA200D, ALA310D, ALA315D, ALA337D, ALA358D, ALA361D, ALA49E, ALA94D, ALA98D, ARG193D, ARG271E, ARG316D, ARG321D, ARG325D, ARG340D, ARG375D, ARG80E, ASN133E, ASN313D, ASN36E, ASN74D, ASP138E, ASP204D, ASP227D, ASP230D, ASP269E, ASP275E, ASP277E, ASP318D, ASP331D, ASP87E, ASP97D, CYS25E, CYS40E, CYS43E, CYS84D, GLN205D, GLN372D, GLU228D, GLU265E, GLU268E, GLU309D, GLU98E, GLY195D, GLY323D, GLY355D, GLY362D, GLY45E, GLY48E, GLY91E, HIS82E, ILE305D, ILE332D, ILE352D, ILE52E, ILE75D, ILE88D, ILE94E, LEU144E, LEU196D, LEU203D, LEU278E, LEU314D, LEU359D, LEU369D, LEU44E, LEU50E, LEU76D, LEU88E, LEU89D, LYS139E, LYS229D, LYS90E, MET335D, MET46E, PHE120D, PHE199D, PHE24E, PHE273E, PHE333D, PHE344D, PHE357D, PHE84E, PHE92D, PRO274E, PRO276E, PRO41E, PRO47E, PRO51E, PRO86E, PRO89E, PRO95D, SER192D, SER201D, SER202D, SER231D, SER233D, SER308D, SER311D, SER312D, SER360D, THR140E, THR232D, THR356D, THR82D, THR99D, TRP226D, TYR188D, TYR194D, TYR270E, TYR272E, TYR317D, TYR322D, TYR329D, TYR336D, TYR363D, TYR364D, TYR368D, TYR83E, TYR85E, TYR92E, TYR96D, TYR97E, VAL142E, VAL191D, VAL197D, VAL279E, VAL320D, VAL39E, VAL42E, VAL53E, VAL93D
• D-F: ALA11F, ALA14F, ALA234D, ALA315D, ALA326D, ALA337D, ALA358D, ALA361D, ALA366D, ALA371D, ALA424D, ALA427D, ALA74F, ALA78F, ALA94D, ARG15F, ARG190D, ARG193D, ARG321D, ARG325D, ARG338D, ARG340D, ARG350D, ARG351D, ARG375D, ARG376D, ARG4F, ARG61F, ARG81F, ARG90F, ASN380D, ASN410D, ASN425D, ASN47F, ASN77F, ASN91D, ASP227D, ASP230D, ASP318D, ASP32F, ASP331D, ASP341D, ASP35F, ASP365D, ASP38F, ASP418D, ASP44F, ASP70F, ASP97D, GLN205D, GLN27F, GLN29F, GLN372D, GLN39F, GLN53F, GLU17F, GLU228D, GLU22F, GLU328D, GLU334D, GLU342D, GLU347D, GLU409D, GLU413D, GLU42F, GLU46F, GLU49F, GLU54F, GLU56F, GLU57F, GLU72F, GLU78D, GLU80F, GLY189D, GLY319D, GLY323D, GLY343D, GLY345D, GLY355D, GLY428D, GLY79D, HIS294D, HIS452D, HIS66F, ILE10F, ILE23F, ILE299D, ILE304D, ILE305D, ILE332D, ILE33F, ILE352D, ILE378D, ILE37F, ILE412D, ILE419D, ILE52F, ILE88D, LEU13F, LEU16F, LEU18F, LEU203D, LEU30F, LEU314D, LEU34F, LEU354D, LEU359D, LEU369D, LEU377D, LEU383D, LEU408D, LEU40F, LEU416D, LEU426D, LEU429D, LEU43F, LEU69F, LEU75F, LEU76D, LEU89D, LEU8F, LYS12F, LYS19F, LYS229D, LYS235D, LYS28F, LYS296D, LYS330D, LYS349D, LYS370D, LYS373D, LYS41F, LYS73F, LYS81D, LYS9F, MET335D, MET353D, MET60F, MET76F, PHE26F, PHE333D, PHE344D, PHE357D, PHE36F, PHE55F, PHE86F, PHE92D, PRO293D, PRO300D, PRO307D, PRO346D, PRO411D, PRO50F, PRO59F, PRO79F, PRO89F, PRO95D, SER201D, SER202D, SER231D, SER233D, SER298D, SER311D, SER31F, SER360D, SER417D, THR187D, THR232D, THR301D, THR339D, THR356D, THR379D, THR45F, THR58F, THR82D, TRP226D, TRP453D, TRP6F, TYR128D, TYR188D, TYR194D, TYR297D, TYR302D, TYR303D, TYR317D, TYR322D, TYR324D, TYR329D, TYR336D, TYR363D, TYR364D, TYR367D, TYR368D, TYR415D, TYR51F, TYR96D, VAL25F, VAL295D, VAL2F, VAL320D, VAL348D, VAL374D, VAL48F, VAL7F, VAL87F, VAL88F, VAL91F, VAL92F, VAL93D
• D-H: ALA385D, ALA67H, ARG120H, ARG376D, ASN104H, ASN110H, ASN380D, ASN69H, ASP300H, ASP381D, CYS70H, GLN301H, GLU108H, GLU115H, GLU259D, GLU262D, GLU281D, GLU286D, GLU289D, GLU289H, GLU304H, GLU387D, GLU388D, GLU71H, GLY105H, HIS294D, HIS73H, ILE287D, LEU292D, LEU298H, LEU377D, LEU383D, LEU66H, LEU68H, LYS116H, LYS118H, LYS172H, LYS253D, LYS258D, LYS285H, LYS288D, LYS292H, LYS296D, LYS308H, LYS373D, LYS384D, MET295H, PHE261D, PRO293D, SER291D, SER65H, THR103H, TRP106H, TYR297D, VAL290D, VAL295D, VAL374D
• E-F: ALA11F, ALA14F, ALA267E, ALA33E, ALA57E, ALA74F, ALA78F, ARG15F, ARG262E, ARG271E, ARG56E, ARG61F, ARG71F, ARG81F, ARG90F, ASN133E, ASN145E, ASN36E, ASN38E, ASN54E, ASN77F, ASP138E, ASP143E, ASP18E, ASP269E, ASP275E, ASP277E, ASP63F, ASP70F, ASP83F, ASP87E, CYS25E, CYS27E, CYS40E, CYS43E, GLN53F, GLU136E, GLU265E, GLU266E, GLU268E, GLU34E, GLU49F, GLU54F, GLU56F, GLU57F, GLU59E, GLU62F, GLU64F, GLU72F, GLU74E, GLU75E, GLU80F, GLU98E, GLY137E, GLY148E, GLY26E, GLY84F, HIS135E, HIS66F, HIS82E, ILE10F, ILE134E, ILE52E, ILE52F, ILE62E, LEU13F, LEU141E, LEU144E, LEU16F, LEU278E, LEU281E, LEU44E, LEU69F, LEU75F, LYS12F, LYS132E, LYS139E, LYS20E, LYS22E, LYS282E, LYS284E, LYS28E, LYS55E, LYS73F, LYS82F, LYS99E, LYS9F, MET23E, MET261E, MET46E, MET60F, PHE24E, PHE55F, PHE78E, PHE84E, PHE85F, PHE86F, PRO150E, PRO274E, PRO276E, PRO280E, PRO35E, PRO41E, PRO47E, PRO50F, PRO51E, PRO59F, PRO65F, PRO67F, PRO86E, PRO89E, PRO89F, SER68F, SER76E, THR140E, THR19E, THR21E, THR263E, THR37E, THR58F, TRP287E, TYR270E, TYR51F, TYR60E, TYR83E, TYR85E, VAL142E, VAL279E, VAL283E, VAL29E, VAL39E, VAL42E, VAL53E, VAL58E, VAL77E, VAL87F, VAL88F, VAL91F, VAL92F
• E-G: ALA385G, ALA67E, ARG120E, ARG122E, ARG376G, ASN104E, ASN110E, ASN380G, ASN69E, ASP159E, ASP300E, ASP381G, CYS70E, GLN301E, GLU108E, GLU115E, GLU259G, GLU262G, GLU281G, GLU286G, GLU289G, GLU304E, GLU387G, GLU388G, GLU71E, GLY105E, HIS294G, HIS73E, ILE287G, LEU292G, LEU298E, LEU377G, LEU383G, LEU66E, LEU68E, LYS116E, LYS118E, LYS172E, LYS258G, LYS285E, LYS288G, LYS292E, LYS296G, LYS308E, LYS370G, LYS373G, LYS384G, MET295E, PHE261G, PHE382G, PRO257G, PRO293G, SER291G, SER65E, THR103E, TRP106E, TYR297G, VAL290G, VAL295G, VAL374G
• E-I: ALA102E, ARG120E, ARG122E, ARG123E, ARG201E, ASN104E, ASN47I, ASP159E, ASP35I, ASP38I, ASP44I, GLN39I, GLU157E, GLU42I, GLU46I, GLU49I, GLU54I, GLU71E, GLU75E, GLU98E, GLY105E, HIS73E, ILE121E, LEU40I, LEU43I, LYS206E, LYS285E, LYS41I, LYS99E, PHE208E, PRO100E, PRO158E, THR103E, THR45I, TYR97E, VAL48I
• F-H: ALA102H, ARG120H, ARG122H, ARG123H, ARG201H, ASN104H, ASN47F, ASP159H, ASP35F, ASP38F, ASP44F, GLN39F, GLU157H, GLU42F, GLU46F, GLU49F, GLU54F, GLU71H, GLU98H, GLY105H, HIS73H, ILE121H, LEU40F, LEU43F, LYS206H, LYS285H, LYS41F, LYS99H, PHE208H, PRO100H, PRO158H, THR103H, THR45F, TYR97H, VAL48F
• G-H: ALA147H, ALA198G, ALA200G, ALA310G, ALA315G, ALA337G, ALA358G, ALA361G, ALA49H, ALA79H, ALA94G, ALA98G, ARG193G, ARG271H, ARG316G, ARG321G, ARG325G, ARG340G, ARG375G, ARG80H, ASN133H, ASN313G, ASN36H, ASN74G, ASP138H, ASP204G, ASP227G, ASP230G, ASP269H, ASP275H, ASP277H, ASP318G, ASP87H, ASP97G, CYS25H, CYS40H, CYS43H, CYS84G, GLN372G, GLU228G, GLU265H, GLU268H, GLU309G, GLU78G, GLU98H, GLY195G, GLY323G, GLY355G, GLY362G, GLY45H, GLY48H, GLY91H, HIS82H, ILE305G, ILE332G, ILE352G, ILE52H, ILE75G, ILE88G, ILE94H, LEU144H, LEU196G, LEU203G, LEU278H, LEU314G, LEU359G, LEU369G, LEU44H, LEU50H, LEU76G, LEU88H, LEU89G, LYS139H, LYS229G, LYS81H, LYS90H, LYS99H, MET335G, MET46H, PHE120G, PHE199G, PHE24H, PHE273H, PHE333G, PHE344G, PHE357G, PHE84H, PHE92G, PRO274H, PRO276H, PRO41H, PRO47H, PRO51H, PRO86H, PRO89H, PRO95G, SER192G, SER201G, SER202G, SER231G, SER233G, SER308G, SER311G, SER312G, SER360G, THR140H, THR232G, THR356G, THR82G, THR99G, TRP226G, TYR188G, TYR194G, TYR270H, TYR272H, TYR317G, TYR322G, TYR329G, TYR336G, TYR363G, TYR364G, TYR368G, TYR83H, TYR85H, TYR92H, TYR96G, TYR97H, VAL142H, VAL197G, VAL279H, VAL320G, VAL39H, VAL42H, VAL53H, VAL77H, VAL93G
• G-I: ALA11I, ALA14I, ALA234G, ALA315G, ALA326G, ALA337G, ALA358G, ALA361G, ALA366G, ALA371G, ALA427G, ALA74I, ALA78I, ALA94G, ARG15I, ARG193G, ARG321G, ARG325G, ARG338G, ARG340G, ARG350G, ARG351G, ARG375G, ARG376G, ARG4I, ARG61I, ARG81I, ARG90I, ASN380G, ASN410G, ASN425G, ASN47I, ASN77I, ASN91G, ASP227G, ASP230G, ASP318G, ASP32I, ASP331G, ASP341G, ASP35I, ASP365G, ASP38I, ASP418G, ASP44I, ASP70I, ASP97G, GLN205G, GLN27I, GLN29I, GLN372G, GLN39I, GLN53I, GLU17I, GLU228G, GLU22I, GLU328G, GLU334G, GLU342G, GLU347G, GLU409G, GLU413G, GLU42I, GLU46I, GLU49I, GLU54I, GLU56I, GLU57I, GLU72I, GLU78G, GLU80I, GLY189G, GLY319G, GLY323G, GLY343G, GLY345G, GLY355G, GLY428G, GLY79G, HIS294G, HIS452G, HIS66I, ILE10I, ILE23I, ILE299G, ILE304G, ILE305G, ILE332G, ILE33I, ILE352G, ILE378G, ILE37I, ILE412G, ILE419G, ILE52I, ILE88G, LEU13I, LEU16I, LEU18I, LEU203G, LEU30I, LEU314G, LEU34I, LEU354G, LEU359G, LEU369G, LEU377G, LEU383G, LEU408G, LEU40I, LEU416G, LEU426G, LEU429G, LEU43I, LEU69I, LEU75I, LEU76G, LEU89G, LEU8I, LYS12I, LYS19I, LYS229G, LYS235G, LYS28I, LYS296G, LYS330G, LYS349G, LYS370G, LYS373G, LYS41I, LYS73I, LYS81G, LYS9I, MET335G, MET353G, MET60I, MET76I, PHE26I, PHE333G, PHE344G, PHE357G, PHE36I, PHE55I, PHE86I, PHE92G, PRO293G, PRO300G, PRO307G, PRO346G, PRO411G, PRO50I, PRO59I, PRO79I, PRO89I, PRO95G, SER201G, SER202G, SER231G, SER233G, SER298G, SER311G, SER31I, SER360G, SER417G, THR232G, THR301G, THR339G, THR356G, THR379G, THR45I, THR58I, THR82G, TRP226G, TRP453G, TRP6I, TYR128G, TYR188G, TYR194G, TYR297G, TYR302G, TYR303G, TYR317G, TYR322G, TYR324G, TYR329G, TYR336G, TYR363G, TYR364G, TYR367G, TYR368G, TYR415G, TYR51I, TYR96G, VAL25I, VAL295G, VAL2I, VAL320G, VAL348G, VAL374G, VAL48I, VAL7I, VAL87I, VAL88I, VAL91I, VAL92I, VAL93G
• G-K: ALA130G, ARG142G, ARG167K, ARG221K, ARG356K, ARG407G, ASN113K, ASN33G, ASN345K, ASN349K, ASN91G, ASP139G, ASP30G, ASP350K, ASP357K, GLN224K, GLU127G, GLU141G, GLU164K, GLU228K, GLU232K, GLU23G, GLU26G, GLU314K, GLU316K, GLU36G, GLU37G, GLU391K, GLU3K, GLU406G, GLU409G, GLU55G, GLU80G, GLU90G, GLY114K, GLY353K, GLY389K, GLY405G, GLY48G, ILE231K, ILE235K, ILE319K, ILE348K, ILE388K, LEU140G, LEU312K, LEU347K, LEU351K, LEU352K, LEU354K, LEU408G, LEU46G, LEU51G, LYS135G, LYS203K, LYS225K, LYS22G, LYS341K, LYS382K, LYS387K, LYS38G, LYS390K, LYS394K, LYS403G, LYS40G, LYS49G, LYS4K, LYS52G, LYS58G, LYS81G, LYS87G, PHE131G, PHE132G, PHE402G, PHE404G, PRO112K, PRO133G, PRO163K, PRO45G, SER313K, SER385K, SER56G, THR162K, THR386K, THR44G, TRP346K, TYR29G, TYR315K, TYR32G, VAL143G
• H-I: ALA11I, ALA14I, ALA267H, ALA33H, ALA57H, ALA74I, ALA78I, ARG15I, ARG262H, ARG271H, ARG56H, ARG61I, ARG71I, ARG81I, ARG90I, ASN133H, ASN145H, ASN36H, ASN38H, ASN54H, ASN77I, ASP138H, ASP143H, ASP18H, ASP269H, ASP275H, ASP277H, ASP63I, ASP70I, ASP83I, ASP87H, CYS25H, CYS27H, CYS40H, CYS43H, GLN53I, GLU136H, GLU265H, GLU266H, GLU268H, GLU34H, GLU49I, GLU54I, GLU56I, GLU57I, GLU59H, GLU62I, GLU64I, GLU72I, GLU74H, GLU75H, GLU80I, GLU98H, GLY137H, GLY148H, GLY26H, GLY84I, HIS135H, HIS66I, HIS82H, ILE10I, ILE134H, ILE52H, ILE52I, ILE62H, LEU13I, LEU141H, LEU144H, LEU16I, LEU278H, LEU281H, LEU44H, LEU69I, LEU75I, LYS12I, LYS132H, LYS139H, LYS20H, LYS22H, LYS282H, LYS284H, LYS28H, LYS55H, LYS73I, LYS82I, LYS99H, LYS9I, MET23H, MET261H, MET46H, MET60I, PHE24H, PHE55I, PHE78H, PHE84H, PHE85I, PHE86I, PRO150H, PRO274H, PRO276H, PRO280H, PRO35H, PRO41H, PRO47H, PRO50I, PRO51H, PRO59I, PRO65I, PRO67I, PRO86H, PRO89H, PRO89I, SER68I, SER76H, THR140H, THR19H, THR21H, THR263H, THR37H, THR58I, TRP287H, TYR270H, TYR51I, TYR60H, TYR83H, TYR85H, VAL142H, VAL279H, VAL283H, VAL29H, VAL39H, VAL42H, VAL53H, VAL58H, VAL77H, VAL87I, VAL88I, VAL91I, VAL92I
• H-M: ASN236H, GLU240H, LYS58M
• I-K: GLN29I, GLU21I, LYS380K, LYS382K, VAL25I
• I-T: ARG4I, ASP3I, GLU408T, GLU5I
• J-K: ALA198J, ALA200J, ALA310J, ALA315J, ALA358J, ALA361J, ALA49K, ALA79K, ALA94J, ALA98J, ARG193J, ARG271K, ARG316J, ARG321J, ARG325J, ARG340J, ARG375J, ARG80K, ASN133K, ASN313J, ASN36K, ASN74J, ASP138K, ASP204J, ASP227J, ASP230J, ASP269K, ASP275K, ASP277K, ASP318J, ASP365J, ASP87K, ASP97J, CYS25K, CYS40K, CYS43K, CYS84J, GLN372J, GLU228J, GLU265K, GLU268K, GLU309J, GLU78J, GLU98K, GLY195J, GLY323J, GLY355J, GLY362J, GLY45K, GLY48K, GLY91K, HIS82K, ILE305J, ILE332J, ILE352J, ILE52K, ILE75J, ILE88J, ILE94K, LEU144K, LEU196J, LEU203J, LEU278K, LEU314J, LEU359J, LEU369J, LEU44K, LEU50K, LEU76J, LEU88K, LEU89J, LYS139K, LYS229J, LYS81K, LYS90K, LYS99K, MET335J, MET46K, PHE120J, PHE199J, PHE24K, PHE273K, PHE333J, PHE344J, PHE357J, PHE84K, PHE92J, PRO274K, PRO276K, PRO41K, PRO47K, PRO51K, PRO86K, PRO89K, PRO95J, SER192J, SER201J, SER202J, SER231J, SER233J, SER308J, SER311J, SER312J, SER360J, THR140K, THR232J, THR356J, THR82J, THR99J, TRP226J, TYR188J, TYR194J, TYR270K, TYR272K, TYR317J, TYR322J, TYR329J, TYR336J, TYR363J, TYR364J, TYR368J, TYR83K, TYR85K, TYR92K, TYR96J, TYR97K, VAL142K, VAL191J, VAL197J, VAL279K, VAL320J, VAL39K, VAL42K, VAL53K, VAL77K, VAL93J
• J-L: ALA11L, ALA14L, ALA234J, ALA315J, ALA326J, ALA337J, ALA358J, ALA361J, ALA366J, ALA371J, ALA427J, ALA74L, ALA78L, ALA94J, ARG15L, ARG190J, ARG193J, ARG321J, ARG325J, ARG338J, ARG340J, ARG350J, ARG351J, ARG375J, ARG376J, ARG4L, ARG61L, ARG81L, ARG90L, ASN380J, ASN410J, ASN425J, ASN47L, ASN77L, ASN91J, ASP227J, ASP230J, ASP318J, ASP32L, ASP331J, ASP341J, ASP35L, ASP365J, ASP38L, ASP418J, ASP44L, ASP70L, ASP97J, GLN205J, GLN27L, GLN29L, GLN372J, GLN39L, GLN53L, GLU17L, GLU228J, GLU22L, GLU328J, GLU334J, GLU342J, GLU347J, GLU409J, GLU413J, GLU42L, GLU46L, GLU49L, GLU54L, GLU56L, GLU57L, GLU72L, GLU78J, GLU80L, GLU90J, GLY189J, GLY319J, GLY323J, GLY343J, GLY345J, GLY355J, GLY428J, GLY79J, HIS294J, HIS452J, HIS66L, ILE10L, ILE23L, ILE299J, ILE304J, ILE305J, ILE332J, ILE33L, ILE352J, ILE378J, ILE37L, ILE412J, ILE419J, ILE52L, ILE88J, LEU13L, LEU16L, LEU18L, LEU203J, LEU30L, LEU314J, LEU34L, LEU354J, LEU359J, LEU369J, LEU377J, LEU383J, LEU408J, LEU40L, LEU416J, LEU426J, LEU429J, LEU43L, LEU69L, LEU75L, LEU76J, LEU89J, LEU8L, LYS12L, LYS19L, LYS229J, LYS235J, LYS28L, LYS296J, LYS330J, LYS349J, LYS370J, LYS373J, LYS41L, LYS73L, LYS81J, LYS9L, MET335J, MET353J, MET60L, MET76L, PHE26L, PHE333J, PHE344J, PHE357J, PHE36L, PHE55L, PHE86L, PHE92J, PRO293J, PRO300J, PRO307J, PRO346J, PRO411J, PRO50L, PRO59L, PRO79L, PRO89L, PRO95J, SER202J, SER231J, SER233J, SER298J, SER311J, SER31L, SER360J, SER417J, THR187J, THR232J, THR301J, THR339J, THR356J, THR379J, THR45L, THR58L, THR82J, TRP226J, TRP453J, TRP6L, TYR128J, TYR188J, TYR194J, TYR297J, TYR302J, TYR303J, TYR317J, TYR322J, TYR324J, TYR329J, TYR336J, TYR363J, TYR364J, TYR367J, TYR368J, TYR415J, TYR51L, TYR96J, VAL25L, VAL295J, VAL2L, VAL320J, VAL348J, VAL374J, VAL48L, VAL7L, VAL87L, VAL88L, VAL91L, VAL92L, VAL93J
• J-Q: ARG16J, ARG60J, ASN236Q, GLU239Q, GLU240Q, GLU243Q, GLU55J, GLU59J, GLU61J, GLY17J, GLY241Q, GLY242Q, LEU57J, LYS15J, LYS257Q, LYS58J, PHE65J, PRO21J, SER20J, SER56J, TYR229Q, TYR259Q, VAL237Q, VAL238Q
• K-L: ALA11L, ALA14L, ALA267K, ALA33K, ALA57K, ALA74L, ALA78L, ARG15L, ARG262K, ARG271K, ARG56K, ARG61L, ARG71L, ARG81L, ARG90L, ASN133K, ASN145K, ASN36K, ASN38K, ASN54K, ASN77L, ASP138K, ASP143K, ASP18K, ASP269K, ASP275K, ASP277K, ASP63L, ASP70L, ASP83L, ASP87K, CYS25K, CYS27K, CYS40K, CYS43K, GLN53L, GLU136K, GLU265K, GLU266K, GLU268K, GLU30K, GLU34K, GLU49L, GLU54L, GLU56L, GLU57L, GLU59K, GLU62L, GLU64L, GLU72L, GLU74K, GLU75K, GLU80L, GLY137K, GLY148K, GLY26K, GLY84L, HIS135K, HIS66L, HIS82K, ILE10L, ILE134K, ILE52K, ILE52L, ILE62K, LEU13L, LEU141K, LEU144K, LEU16L, LEU278K, LEU281K, LEU44K, LEU69L, LEU75L, LYS12L, LYS132K, LYS139K, LYS20K, LYS22K, LYS282K, LYS284K, LYS28K, LYS55K, LYS73L, LYS82L, LYS99K, LYS9L, MET23K, MET46K, MET60L, PHE24K, PHE55L, PHE78K, PHE84K, PHE85L, PHE86L, PRO150K, PRO274K, PRO276K, PRO280K, PRO35K, PRO41K, PRO47K, PRO50L, PRO51K, PRO59L, PRO65L, PRO67L, PRO86K, PRO89K, PRO89L, SER68L, SER76K, THR140K, THR19K, THR21K, THR263K, THR37K, THR58L, TRP287K, TYR270K, TYR51L, TYR60K, TYR83K, TYR85K, VAL142K, VAL279K, VAL283K, VAL29K, VAL39K, VAL42K, VAL53K, VAL58K, VAL77K, VAL87L, VAL88L, VAL91L, VAL92L
• K-N: ARG335K, GLN405K, GLN405N, GLU370K, GLU374K, GLU374N, GLU381K, GLU381N, GLU408K, GLU408N, GLU409N, GLY411N, HIS336K, HIS336N, ILE384K, LEU378K, LEU378N, LEU412K, LEU412N, LYS338K, LYS377K, LYS377N, LYS410N, PHE337K, PRO403K, PRO403N, SER404K, SER404N, THR402K, THR402N, VAL383K, VAL407K, VAL407N
• M-N: ALA198M, ALA200M, ALA310M, ALA315M, ALA358M, ALA361M, ALA49N, ALA94M, ALA98M, ARG193M, ARG271N, ARG316M, ARG321M, ARG325M, ARG340M, ARG375M, ARG80N, ASN133N, ASN313M, ASN36N, ASN74M, ASP138N, ASP204M, ASP227M, ASP230M, ASP269N, ASP275N, ASP277N, ASP318M, ASP365M, ASP87N, ASP97M, CYS25N, CYS40N, CYS43N, CYS84M, GLN372M, GLU228M, GLU265N, GLU268N, GLU309M, GLU78M, GLU98N, GLY195M, GLY26N, GLY323M, GLY355M, GLY362M, GLY45N, GLY48N, GLY91N, HIS82N, ILE305M, ILE332M, ILE352M, ILE52N, ILE75M, ILE88M, ILE94N, LEU144N, LEU196M, LEU203M, LEU278N, LEU314M, LEU359M, LEU369M, LEU44N, LEU50N, LEU76M, LEU88N, LEU89M, LYS139N, LYS229M, LYS235M, LYS81N, LYS90N, MET335M, MET46N, PHE120M, PHE199M, PHE24N, PHE273N, PHE333M, PHE344M, PHE357M, PHE84N, PHE92M, PRO274N, PRO276N, PRO41N, PRO47N, PRO51N, PRO86N, PRO89N, PRO95M, SER192M, SER201M, SER202M, SER231M, SER233M, SER308M, SER311M, SER312M, SER360M, THR140N, THR232M, THR356M, THR82M, THR99M, TRP226M, TYR188M, TYR194M, TYR270N, TYR272N, TYR317M, TYR322M, TYR329M, TYR336M, TYR363M, TYR364M, TYR368M, TYR83N, TYR85N, TYR92N, TYR96M, TYR97N, VAL142N, VAL191M, VAL197M, VAL279N, VAL320M, VAL39N, VAL42N, VAL53N, VAL93M
• M-O: ALA11O, ALA14O, ALA234M, ALA315M, ALA326M, ALA337M, ALA358M, ALA361M, ALA366M, ALA371M, ALA424M, ALA427M, ALA74O, ALA78O, ALA94M, ARG15O, ARG190M, ARG193M, ARG321M, ARG325M, ARG338M, ARG340M, ARG350M, ARG351M, ARG375M, ARG376M, ARG4O, ARG61O, ARG81O, ARG90O, ASN380M, ASN410M, ASN425M, ASN47O, ASN77O, ASN91M, ASP227M, ASP230M, ASP318M, ASP32O, ASP331M, ASP341M, ASP35O, ASP365M, ASP38O, ASP418M, ASP44O, ASP70O, ASP97M, GLN205M, GLN27O, GLN29O, GLN372M, GLN39O, GLN53O, GLU17O, GLU228M, GLU22O, GLU328M, GLU334M, GLU342M, GLU347M, GLU409M, GLU413M, GLU42O, GLU46O, GLU49O, GLU54O, GLU56O, GLU57O, GLU72O, GLU78M, GLU80O, GLU90M, GLY189M, GLY319M, GLY323M, GLY343M, GLY345M, GLY355M, GLY428M, GLY79M, HIS294M, HIS452M, HIS66O, ILE10O, ILE23O, ILE299M, ILE304M, ILE305M, ILE332M, ILE33O, ILE352M, ILE378M, ILE37O, ILE412M, ILE419M, ILE52O, LEU13O, LEU16O, LEU18O, LEU203M, LEU30O, LEU314M, LEU34O, LEU354M, LEU359M, LEU369M, LEU377M, LEU383M, LEU408M, LEU40O, LEU416M, LEU426M, LEU429M, LEU43O, LEU69O, LEU75O, LEU76M, LEU89M, LEU8O, LYS12O, LYS19O, LYS229M, LYS235M, LYS28O, LYS296M, LYS330M, LYS349M, LYS370M, LYS373M, LYS41O, LYS73O, LYS81M, LYS9O, MET335M, MET353M, MET60O, MET76O, PHE26O, PHE333M, PHE344M, PHE357M, PHE36O, PHE55O, PHE86O, PHE92M, PRO293M, PRO300M, PRO307M, PRO346M, PRO411M, PRO50O, PRO59O, PRO79O, PRO89O, PRO95M, SER202M, SER231M, SER233M, SER298M, SER311M, SER31O, SER360M, SER417M, THR187M, THR232M, THR301M, THR339M, THR356M, THR379M, THR45O, THR58O, THR82M, TRP226M, TRP453M, TRP6O, TYR128M, TYR188M, TYR194M, TYR297M, TYR302M, TYR303M, TYR317M, TYR322M, TYR324M, TYR329M, TYR336M, TYR363M, TYR364M, TYR367M, TYR368M, TYR415M, TYR51O, TYR96M, VAL25O, VAL295M, VAL2O, VAL320M, VAL348M, VAL374M, VAL48O, VAL7O, VAL87O, VAL88O, VAL91O, VAL92O, VAL93M
• N-O: ALA11O, ALA14O, ALA267N, ALA33N, ALA57N, ALA74O, ALA78O, ARG15O, ARG262N, ARG271N, ARG56N, ARG61O, ARG71O, ARG81O, ARG90O, ASN133N, ASN145N, ASN36N, ASN38N, ASN54N, ASN77O, ASP138N, ASP143N, ASP18N, ASP269N, ASP275N, ASP277N, ASP63O, ASP70O, ASP83O, ASP87N, CYS25N, CYS27N, CYS40N, CYS43N, GLN53O, GLU136N, GLU265N, GLU266N, GLU268N, GLU34N, GLU49O, GLU54O, GLU56O, GLU57O, GLU59N, GLU62O, GLU64O, GLU72O, GLU74N, GLU75N, GLU80O, GLY137N, GLY148N, GLY26N, GLY84O, HIS135N, HIS66O, HIS82N, ILE10O, ILE134N, ILE52N, ILE52O, ILE62N, LEU13O, LEU141N, LEU144N, LEU16O, LEU278N, LEU281N, LEU44N, LEU69O, LEU75O, LYS12O, LYS132N, LYS139N, LYS20N, LYS22N, LYS282N, LYS284N, LYS28N, LYS55N, LYS73O, LYS82O, LYS99N, LYS9O, MET23N, MET261N, MET46N, MET60O, PHE24N, PHE55O, PHE78N, PHE84N, PHE85O, PHE86O, PRO150N, PRO274N, PRO276N, PRO280N, PRO35N, PRO41N, PRO47N, PRO50O, PRO51N, PRO59O, PRO65O, PRO67O, PRO86N, PRO89N, PRO89O, SER68O, SER76N, THR140N, THR19N, THR21N, THR263N, THR37N, THR58O, TRP287N, TYR270N, TYR51O, TYR60N, TYR83N, TYR85N, VAL142N, VAL279N, VAL283N, VAL29N, VAL39N, VAL42N, VAL53N, VAL58N, VAL77N, VAL87O, VAL88O, VAL91O, VAL92O
• N-P: ALA130P, ARG142P, ARG167N, ARG221N, ARG356N, ARG407P, ASN113N, ASN33P, ASN345N, ASN349N, ASP30P, ASP350N, ASP357N, GLN224N, GLU115N, GLU127P, GLU141P, GLU164N, GLU228N, GLU232N, GLU23P, GLU26P, GLU314N, GLU316N, GLU36P, GLU37P, GLU391N, GLU3N, GLU406P, GLU409P, GLU55P, GLU80P, GLU90P, GLY114N, GLY311N, GLY353N, GLY389N, GLY405P, GLY48P, ILE231N, ILE319N, ILE348N, ILE388N, ILE43P, LEU111N, LEU140P, LEU312N, LEU351N, LEU352N, LEU354N, LEU408P, LEU46P, LEU51P, LYS135P, LYS203N, LYS225N, LYS22P, LYS308N, LYS327P, LYS341N, LYS382N, LYS387N, LYS38P, LYS390N, LYS394N, LYS403P, LYS40P, LYS49P, LYS4N, LYS52P, LYS58P, LYS81P, LYS87P, PHE131P, PHE132P, PHE402P, PHE404P, PRO112N, PRO133P, PRO163N, PRO346P, PRO45P, SER129P, SER313N, SER385N, SER56P, THR162N, THR386N, THR44P, TRP346N, TYR29P, TYR315N, TYR47P, VAL143P, VAL39P
• N-R: GLN29R, GLU21R, GLU24R, LYS380N, LYS382N, VAL25R
• O-V: ARG81O, ASP440V, ASP83O, GLU271V, GLU274V, GLU80O, LYS278V, LYS439V, LYS82O
• P-Q: ALA198P, ALA200P, ALA310P, ALA315P, ALA358P, ALA361P, ALA49Q, ALA94P, ALA98P, ARG193P, ARG271Q, ARG316P, ARG321P, ARG325P, ARG340P, ARG375P, ARG80Q, ASN133Q, ASN313P, ASN36Q, ASN74P, ASP138Q, ASP204P, ASP227P, ASP230P, ASP269Q, ASP275Q, ASP277Q, ASP318P, ASP365P, ASP87Q, ASP97P, CYS25Q, CYS40Q, CYS43Q, CYS84P, GLN372P, GLU228P, GLU265Q, GLU268Q, GLU309P, GLU78P, GLU98Q, GLY195P, GLY26Q, GLY323P, GLY355P, GLY362P, GLY45Q, GLY48Q, GLY91Q, HIS82Q, ILE305P, ILE332P, ILE352P, ILE52Q, ILE75P, ILE88P, ILE94Q, LEU144Q, LEU196P, LEU203P, LEU278Q, LEU314P, LEU359P, LEU369P, LEU44Q, LEU50Q, LEU76P, LEU88Q, LEU89P, LYS139Q, LYS229P, LYS81Q, LYS90Q, LYS99Q, MET335P, MET46Q, PHE120P, PHE199P, PHE24Q, PHE273Q, PHE333P, PHE344P, PHE357P, PHE84Q, PHE92P, PRO274Q, PRO276Q, PRO41Q, PRO47Q, PRO51Q, PRO86Q, PRO89Q, PRO95P, SER192P, SER201P, SER202P, SER231P, SER233P, SER308P, SER311P, SER312P, SER360P, THR140Q, THR232P, THR356P, THR82P, THR99P, TRP226P, TYR188P, TYR194P, TYR270Q, TYR272Q, TYR317P, TYR322P, TYR329P, TYR336P, TYR363P, TYR364P, TYR368P, TYR83Q, TYR85Q, TYR92Q, TYR96P, TYR97Q, VAL142Q, VAL191P, VAL197P, VAL279Q, VAL320P, VAL39Q, VAL42Q, VAL53Q, VAL93P
• P-R: ALA11R, ALA14R, ALA234P, ALA315P, ALA326P, ALA337P, ALA358P, ALA361P, ALA366P, ALA371P, ALA424P, ALA427P, ALA74R, ALA78R, ALA94P, ARG15R, ARG190P, ARG193P, ARG321P, ARG325P, ARG338P, ARG340P, ARG350P, ARG351P, ARG375P, ARG376P, ARG4R, ARG61R, ARG81R, ARG90R, ASN380P, ASN410P, ASN425P, ASN47R, ASN77R, ASN91P, ASP227P, ASP230P, ASP318P, ASP32R, ASP331P, ASP341P, ASP35R, ASP365P, ASP38R, ASP418P, ASP44R, ASP70R, ASP97P, GLN205P, GLN27R, GLN29R, GLN372P, GLN39R, GLN53R, GLU17R, GLU228P, GLU22R, GLU328P, GLU334P, GLU342P, GLU347P, GLU409P, GLU413P, GLU42R, GLU46R, GLU49R, GLU54R, GLU56R, GLU57R, GLU72R, GLU78P, GLU80R, GLY189P, GLY319P, GLY323P, GLY343P, GLY345P, GLY355P, GLY428P, GLY79P, HIS294P, HIS452P, HIS66R, ILE10R, ILE23R, ILE299P, ILE304P, ILE305P, ILE332P, ILE33R, ILE352P, ILE378P, ILE37R, ILE412P, ILE419P, ILE52R, ILE88P, LEU13R, LEU16R, LEU18R, LEU203P, LEU30R, LEU314P, LEU34R, LEU354P, LEU359P, LEU369P, LEU377P, LEU383P, LEU408P, LEU40R, LEU416P, LEU426P, LEU429P, LEU43R, LEU69R, LEU75R, LEU76P, LEU89P, LEU8R, LYS12R, LYS19R, LYS229P, LYS235P, LYS28R, LYS296P, LYS330P, LYS349P, LYS370P, LYS373P, LYS41R, LYS73R, LYS81P, LYS9R, MET335P, MET353P, MET60R, MET76R, PHE26R, PHE333P, PHE344P, PHE357P, PHE36R, PHE55R, PHE86R, PHE92P, PRO293P, PRO300P, PRO307P, PRO346P, PRO411P, PRO50R, PRO59R, PRO79R, PRO89R, PRO95P, SER202P, SER231P, SER233P, SER298P, SER311P, SER31R, SER360P, SER417P, THR187P, THR232P, THR301P, THR339P, THR356P, THR379P, THR45R, THR58R, THR82P, TRP226P, TRP453P, TRP6R, TYR128P, TYR188P, TYR194P, TYR297P, TYR302P, TYR303P, TYR317P, TYR322P, TYR324P, TYR329P, TYR336P, TYR363P, TYR364P, TYR367P, TYR368P, TYR415P, TYR51R, TYR96P, VAL236P, VAL25R, VAL295P, VAL2R, VAL320P, VAL348P, VAL374P, VAL48R, VAL7R, VAL87R, VAL88R, VAL91R, VAL92R, VAL93P
• P-S: ARG325S, GLU281P, LYS278P, LYS282P, LYS327S, TYR329S
• P-U: ARG81U, ASP440P, ASP83U, GLU271P, GLU274P, GLU80U, LYS278P, LYS439P, LYS82U
• Q-R: ALA11R, ALA14R, ALA267Q, ALA33Q, ALA57Q, ALA74R, ALA78R, ARG15R, ARG262Q, ARG271Q, ARG56Q, ARG61R, ARG71R, ARG81R, ARG90R, ASN133Q, ASN145Q, ASN36Q, ASN38Q, ASN54Q, ASN77R, ASP138Q, ASP143Q, ASP18Q, ASP269Q, ASP275Q, ASP277Q, ASP63R, ASP70R, ASP83R, ASP87Q, CYS25Q, CYS27Q, CYS40Q, CYS43Q, GLN53R, GLU136Q, GLU265Q, GLU266Q, GLU268Q, GLU34Q, GLU49R, GLU54R, GLU56R, GLU57R, GLU59Q, GLU62R, GLU64R, GLU72R, GLU74Q, GLU75Q, GLU80R, GLY137Q, GLY148Q, GLY26Q, GLY84R, HIS135Q, HIS66R, HIS82Q, ILE10R, ILE134Q, ILE52Q, ILE52R, ILE62Q, LEU13R, LEU141Q, LEU144Q, LEU16R, LEU278Q, LEU281Q, LEU44Q, LEU69R, LEU75R, LYS12R, LYS132Q, LYS139Q, LYS20Q, LYS22Q, LYS282Q, LYS284Q, LYS28Q, LYS55Q, LYS73R, LYS82R, LYS99Q, LYS9R, MET23Q, MET261Q, MET46Q, MET60R, PHE24Q, PHE55R, PHE78Q, PHE84Q, PHE85R, PHE86R, PRO150Q, PRO274Q, PRO276Q, PRO280Q, PRO35Q, PRO41Q, PRO47Q, PRO50R, PRO51Q, PRO59R, PRO65R, PRO67R, PRO86Q, PRO89Q, PRO89R, SER68R, SER76Q, THR140Q, THR19Q, THR21Q, THR263Q, THR37Q, THR58R, TRP287Q, TYR270Q, TYR51R, TYR60Q, TYR83Q, TYR85Q, VAL142Q, VAL279Q, VAL283Q, VAL29Q, VAL39Q, VAL42Q, VAL53Q, VAL58Q, VAL77Q, VAL87R, VAL88R, VAL91R, VAL92R
• S-T: ALA361S, ARG193S, ARG316S, ARG321S, ARG80T, ASP230S, ASP269T, ASP275T, ASP277T, ASP318S, GLU309S, GLY195S, GLY45T, GLY48T, LEU44T, LYS90T, MET46T, PRO51T, PRO89T, SER231S, TYR322S, TYR92T
• S-U: ALA14U, ALA337S, ARG15U, ARG325S, ARG338S, ARG340S, ARG350S, ARG376S, ARG61U, ASN77U, ASP341S, ASP44U, GLN372S, GLN53U, GLU17U, GLU228S, GLU22U, GLU334S, GLU342S, GLU46U, GLU49U, GLU54U, GLU57U, GLU78S, GLU80U, HIS452S, HIS66U, ILE52U, LEU43U, LYS19U, LYS229S, LYS235S, LYS349S, LYS370S, LYS373S, LYS41U, LYS73U, THR232S, THR45U, TYR51U, VAL93S
• T-U: ARG15U, ARG56T, ARG61U, ARG71U, ARG90U, ASN54T, ASP138T, ASP269T, ASP63U, ASP83U, CYS25T, GLU136T, GLU268T, GLU34T, GLU56U, GLU57U, GLU59T, GLU62U, GLU64U, GLU80U, GLY137T, GLY26T, HIS135T, HIS66U, ILE52T, LEU69U, LYS12U, LYS139T, LYS20T, LYS22T, LYS282T, LYS284T, LYS55T, LYS82U, LYS9U, MET23T, PHE86U, THR140T, THR58U, VAL142T, VAL39T, VAL53T, VAL88U
• T-V: ARG356T, ASN349T, ASP357T, GLU141V, GLU228T, GLU26V, GLU37V, GLU391T, GLU3T, GLU406V, GLU409V, GLU55V, LYS135V, LYS387T, LYS38V, LYS390T, LYS394T, LYS403V, LYS40V, LYS52V
• V-W: ALA361V, ARG193V, ARG316V, ARG321V, ARG80W, ASN313V, ASP230V, ASP269W, ASP275W, ASP277W, GLU309V, GLY195V, GLY45W, GLY48W, LEU44W, LYS90W, MET46W, PRO51W, PRO89W, SER231V, TYR322V, TYR92W
• V-X: ALA14X, ALA337V, ARG15X, ARG325V, ARG338V, ARG340V, ARG350V, ARG376V, ARG61X, ASN77X, ASP341V, ASP44X, GLN372V, GLN53X, GLU17X, GLU228V, GLU22X, GLU334V, GLU342V, GLU46X, GLU49X, GLU54X, GLU57X, GLU78V, GLU80X, HIS452V, HIS66X, LEU43X, LYS19X, LYS229V, LYS235V, LYS349V, LYS370V, LYS373V, LYS73X, THR232V, THR45X, TYR51X, VAL93V
• W-X: ARG15X, ARG56W, ARG61X, ARG71X, ARG90X, ASN54W, ASP138W, ASP63X, ASP83X, CYS25W, GLU136W, GLU268W, GLU34W, GLU56X, GLU57X, GLU59W, GLU62X, GLU64X, GLU80X, GLY26W, HIS135W, HIS66X, ILE52W, LEU69X, LYS12X, LYS139W, LYS20W, LYS22W, LYS282W, LYS284W, LYS55W, LYS82X, MET23W, PHE86X, THR140W, THR21W, THR58X, VAL142W, VAL39W, VAL53W, VAL88X