3GYR

structure of phenoxazinone synthase from streptomyces antibioticus reveals a new type 2 copper center.

• Total interactions analyzed: 66
• Total true interactions: 18
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 11
  • Norm. En. per Res.: -9.2688
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-20.4991	-71.2779	-184.281	-276.058	67	10	2	6867	10	30	18
A-F	-8.9339	-96.4046	-172.486	-277.8244	65	9	2	6697	8	31	18
A-I	-80.7536	-144.0702	-586.2	-811.0238	196	37	10	22807	12	67	77
B-C	-16.7638	-112.6963	-167.505	-296.9651	65	11	3	6744	10	31	18
B-H	-90.5886	-118.5052	-568.432	-777.5258	197	34	10	22592	11	66	78
C-D	-7.816	-104.6229	-177.799	-290.238	65	6	2	6674	9	32	18
C-G	-71.1114	-111.2176	-576.318	-758.647	195	33	11	22496	12	67	75
D-E	-15.2379	-94.363	-175.831	-285.4319	66	9	2	6658	9	32	17
D-L	-104.5921	-136.4047	-123.085	-364.0818	73	13	0	4848	9	25	21
E-F	-12.1556	-71.3544	-179.056	-262.566	65	11	3	6746	11	33	20
E-K	-109.5099	-126.7347	-561.517	-797.7616	197	31	10	22131	11	67	79
F-J	-78.0189	-115.393	-562.247	-755.6589	196	33	10	22538	10	67	77
G-H	-20.3368	-99.7015	-175.74	-295.7783	65	11	2	6692	9	31	18
G-L	-18.094	-104.318	-122.314	-244.726	52	3	1	4696	0	15	8
H-I	-7.4701	-108.5506	-176.844	-292.8648	65	9	2	6756	10	32	18
I-J	-26.0346	-101.0265	-165.548	-292.6091	67	17	2	6819	8	32	18
J-K	-15.0571	-98.2499	-182.197	-295.5041	68	8	2	6855	8	32	20
K-L	-8.8721	-93.0757	-0.0094	-101.9572	11	0	0	5	0	1	2

Interface residues

• A-B: ALA229B, ALA420B, ALA45A, ARG101B, ARG142A, ARG255A, ARG259A, ARG292A, ARG345B, ARG430B, ARG431B, ARG70A, ARG75A, ASN257A, ASP224B, ASP225B, ASP228B, ASP249A, ASP251A, ASP253A, GLN79A, GLU118A, GLU226B, GLU227B, GLU252A, GLU423B, GLY231B, GLY254A, GLY258A, GLY39A, GLY427B, HIS77A, LEU230B, LEU232B, LEU256A, LEU260A, LEU342B, LEU343B, LEU41A, LEU421B, LEU425B, LEU76A, LEU80A, LEU84A, PHE419B, PHE429B, PRO120A, PRO147A, PRO344B, PRO346B, PRO422B, PRO47A, PRO71A, PRO78A, PRO81A, PRO82A, SER418B, SER426B, SER428B, THR122A, THR250A, THR72A, THR83A, TRP73A, TYR119A, VAL424B, VAL74A
• A-F: ALA229A, ALA420A, ALA45F, ALA46F, ARG101A, ARG255F, ARG259F, ARG345A, ARG430A, ARG431A, ARG70F, ARG75F, ASN257F, ASP224A, ASP225A, ASP228A, ASP249F, ASP251F, ASP253F, GLN79F, GLU118F, GLU226A, GLU227A, GLU252F, GLU423A, GLY231A, GLY254F, GLY258F, GLY39F, GLY427A, GLY90F, HIS77F, LEU230A, LEU232A, LEU256F, LEU260F, LEU342A, LEU343A, LEU41F, LEU421A, LEU425A, LEU76F, LEU80F, LEU84F, PHE419A, PHE429A, PRO120F, PRO344A, PRO346A, PRO422A, PRO71F, PRO78F, PRO81F, PRO82F, SER418A, SER426A, SER428A, THR122F, THR250F, THR72F, THR83F, TRP73F, TYR119F, VAL424A, VAL74F
• A-I: ALA108A, ALA108I, ALA152A, ALA152I, ALA153A, ALA153I, ALA156A, ALA156I, ALA175A, ALA175I, ALA178A, ALA178I, ALA184A, ALA184I, ALA204A, ALA204I, ALA595A, ALA595I, ALA624A, ALA624I, ARG104A, ARG104I, ARG106A, ARG106I, ARG112A, ARG112I, ARG209A, ARG209I, ARG598A, ARG598I, ARG615A, ARG615I, ARG63A, ARG63I, ASN111A, ASN111I, ASN148A, ASN148I, ASN171A, ASN171I, ASN177A, ASN177I, ASN206A, ASN206I, ASN211A, ASN211I, ASN499A, ASN499I, ASP150A, ASP150I, ASP172A, ASP172I, ASP176A, ASP176I, ASP183A, ASP183I, ASP500A, ASP500I, ASP610A, ASP610I, ASP628A, ASP628I, GLN185A, GLN185I, GLU125I, GLU188A, GLU188I, GLU508A, GLU508I, GLU60A, GLU60I, GLU623A, GLU623I, GLU64A, GLU64I, GLU66A, GLU66I, GLY168A, GLY168I, GLY169A, GLY169I, GLY170A, GLY170I, GLY173A, GLY173I, GLY180A, GLY180I, GLY182A, GLY182I, GLY501A, GLY501I, GLY503A, GLY503I, GLY594A, GLY594I, GLY597A, GLY597I, GLY612A, GLY612I, HIS456A, ILE107A, ILE107I, ILE207A, ILE207I, ILE67A, ILE67I, LEU154A, LEU154I, LEU186A, LEU186I, LEU502A, LEU502I, LEU625A, LEU625I, LYS115A, LYS115I, LYS149A, LYS149I, LYS276A, LYS276I, LYS626A, LYS626I, MET205A, MET205I, MET600A, MET600I, MET611A, MET611I, MET614A, MET614I, MET620A, MET620I, PHE181A, PHE181I, PHE498A, PHE498I, PHE599A, PHE599I, PHE617A, PHE617I, PHE627A, PHE627I, PRO155A, PRO155I, PRO190A, PRO190I, PRO616A, PRO616I, PRO621A, PRO621I, PRO622A, PRO622I, SER123A, SER123I, SER158A, SER158I, SER187A, SER187I, THR110A, THR110I, THR167A, THR167I, THR497A, THR497I, THR505A, THR505I, THR62A, THR62I, THR65A, THR65I, TRP109A, TRP109I, TRP157A, TRP157I, TRP174A, TRP174I, TRP210A, TRP210I, TYR189A, TYR189I, TYR596A, TYR596I, VAL105A, VAL105I, VAL151A, VAL151I, VAL159A, VAL159I, VAL179A, VAL179I, VAL618A, VAL618I, VAL619A, VAL619I, VAL61A, VAL61I
• B-C: ALA229C, ALA420C, ALA45B, ALA46B, ARG101C, ARG255B, ARG259B, ARG345C, ARG430C, ARG431C, ARG70B, ARG75B, ASN257B, ASP224C, ASP225C, ASP228C, ASP249B, ASP251B, ASP253B, GLN79B, GLU118B, GLU226C, GLU227C, GLU252B, GLU423C, GLY231C, GLY254B, GLY258B, GLY39B, GLY427C, GLY90B, HIS77B, LEU230C, LEU232C, LEU256B, LEU260B, LEU342C, LEU343C, LEU41B, LEU421C, LEU425C, LEU76B, LEU80B, LEU84B, PHE419C, PHE429C, PRO120B, PRO344C, PRO346C, PRO422C, PRO71B, PRO78B, PRO81B, PRO82B, SER418C, SER426C, SER428C, THR122B, THR250B, THR72B, THR83B, TRP73B, TYR119B, VAL424C, VAL74B
• B-H: ALA108B, ALA108H, ALA152B, ALA152H, ALA153B, ALA153H, ALA156B, ALA156H, ALA175B, ALA175H, ALA178B, ALA178H, ALA184B, ALA184H, ALA204B, ALA204H, ALA595B, ALA595H, ALA624B, ALA624H, ARG104B, ARG104H, ARG106B, ARG106H, ARG112B, ARG112H, ARG209B, ARG209H, ARG598B, ARG598H, ARG615B, ARG615H, ARG63B, ARG63H, ASN111B, ASN111H, ASN148B, ASN148H, ASN171B, ASN171H, ASN177B, ASN177H, ASN206B, ASN206H, ASN211B, ASN211H, ASN499B, ASN499H, ASP150B, ASP150H, ASP172B, ASP172H, ASP176B, ASP176H, ASP183B, ASP183H, ASP192B, ASP500B, ASP500H, ASP610B, ASP610H, ASP628B, ASP628H, GLN185B, GLN185H, GLU125H, GLU188B, GLU188H, GLU508B, GLU508H, GLU60B, GLU60H, GLU623B, GLU623H, GLU64B, GLU64H, GLU66B, GLU66H, GLY168B, GLY168H, GLY169B, GLY169H, GLY170B, GLY170H, GLY173B, GLY173H, GLY180B, GLY180H, GLY182B, GLY182H, GLY501B, GLY501H, GLY503B, GLY503H, GLY594B, GLY594H, GLY597B, GLY597H, GLY612B, GLY612H, ILE107B, ILE107H, ILE207B, ILE207H, ILE67B, ILE67H, LEU154B, LEU154H, LEU186B, LEU186H, LEU502B, LEU502H, LEU625B, LEU625H, LYS115B, LYS115H, LYS149B, LYS149H, LYS276B, LYS276H, LYS626B, LYS626H, MET205B, MET205H, MET600B, MET600H, MET611B, MET611H, MET614B, MET614H, MET620B, MET620H, PHE181B, PHE181H, PHE498B, PHE498H, PHE599B, PHE599H, PHE617B, PHE617H, PHE627B, PHE627H, PRO155B, PRO155H, PRO190B, PRO190H, PRO616B, PRO616H, PRO621B, PRO621H, PRO622B, PRO622H, SER123B, SER123H, SER158B, SER158H, SER187B, SER187H, SER58B, THR110B, THR110H, THR167B, THR167H, THR497B, THR497H, THR505B, THR505H, THR62B, THR62H, THR65B, THR65H, TRP109B, TRP109H, TRP157B, TRP157H, TRP174B, TRP174H, TRP210B, TRP210H, TYR189B, TYR189H, TYR596B, TYR596H, VAL105B, VAL105H, VAL151B, VAL151H, VAL159B, VAL159H, VAL179B, VAL179H, VAL618B, VAL618H, VAL619B, VAL619H, VAL61B, VAL61H
• C-D: ALA229D, ALA420D, ALA45C, ARG101D, ARG255C, ARG259C, ARG345D, ARG430D, ARG431D, ARG70C, ARG75C, ASN257C, ASP224D, ASP225D, ASP228D, ASP249C, ASP251C, ASP253C, GLN79C, GLU118C, GLU226D, GLU227D, GLU252C, GLU423D, GLY231D, GLY254C, GLY258C, GLY39C, GLY427D, GLY90C, HIS77C, LEU230D, LEU232D, LEU256C, LEU260C, LEU342D, LEU343D, LEU41C, LEU421D, LEU425D, LEU76C, LEU80C, LEU84C, PHE419D, PHE429D, PRO120C, PRO147C, PRO344D, PRO346D, PRO422D, PRO71C, PRO78C, PRO81C, PRO82C, SER418D, SER426D, SER428D, THR122C, THR250C, THR72C, THR83C, TRP73C, TYR119C, VAL424D, VAL74C
• C-G: ALA108C, ALA108G, ALA152C, ALA152G, ALA153C, ALA153G, ALA156C, ALA156G, ALA175C, ALA175G, ALA178C, ALA178G, ALA184C, ALA184G, ALA204C, ALA204G, ALA595C, ALA595G, ALA624C, ALA624G, ARG104C, ARG104G, ARG106C, ARG106G, ARG112C, ARG112G, ARG209C, ARG209G, ARG598C, ARG598G, ARG615C, ARG615G, ARG63C, ARG63G, ASN111C, ASN111G, ASN148C, ASN148G, ASN171C, ASN171G, ASN177C, ASN177G, ASN206C, ASN206G, ASN211C, ASN211G, ASN499C, ASN499G, ASP150C, ASP150G, ASP172C, ASP172G, ASP176C, ASP176G, ASP183C, ASP183G, ASP500C, ASP500G, ASP610C, ASP610G, ASP628C, ASP628G, GLN185C, GLN185G, GLU188C, GLU188G, GLU508C, GLU508G, GLU60C, GLU60G, GLU623C, GLU623G, GLU64C, GLU64G, GLU66C, GLU66G, GLY168C, GLY168G, GLY169C, GLY169G, GLY170C, GLY170G, GLY173C, GLY173G, GLY180C, GLY180G, GLY182C, GLY182G, GLY501C, GLY501G, GLY503C, GLY503G, GLY594C, GLY594G, GLY597C, GLY597G, GLY612C, GLY612G, ILE107C, ILE107G, ILE207C, ILE207G, ILE67C, ILE67G, LEU154C, LEU154G, LEU186C, LEU186G, LEU502C, LEU502G, LEU625C, LEU625G, LYS115C, LYS115G, LYS149C, LYS149G, LYS276C, LYS276G, LYS626C, LYS626G, MET205C, MET205G, MET600C, MET600G, MET611C, MET611G, MET614C, MET614G, MET620C, MET620G, PHE181C, PHE181G, PHE498C, PHE498G, PHE504C, PHE599C, PHE599G, PHE617C, PHE617G, PHE627C, PHE627G, PRO155C, PRO155G, PRO190C, PRO190G, PRO616C, PRO616G, PRO621C, PRO621G, PRO622C, PRO622G, SER123C, SER123G, SER158C, SER158G, SER187C, SER187G, THR110C, THR110G, THR167C, THR167G, THR497C, THR497G, THR505C, THR505G, THR62C, THR62G, THR65C, THR65G, TRP109C, TRP109G, TRP157C, TRP157G, TRP174C, TRP174G, TRP210C, TRP210G, TYR189C, TYR189G, TYR596C, TYR596G, VAL105C, VAL105G, VAL151C, VAL151G, VAL159C, VAL159G, VAL179C, VAL179G, VAL618C, VAL618G, VAL619C, VAL619G, VAL61C, VAL61G
• D-E: ALA229E, ALA420E, ALA45D, ALA46D, ARG101E, ARG255D, ARG259D, ARG292D, ARG345E, ARG430E, ARG431E, ARG70D, ARG75D, ASN257D, ASP224E, ASP225E, ASP228E, ASP249D, ASP251D, ASP253D, GLN79D, GLU118D, GLU226E, GLU227E, GLU252D, GLU423E, GLY231E, GLY254D, GLY258D, GLY39D, GLY427E, GLY90D, HIS77D, LEU230E, LEU232E, LEU256D, LEU260D, LEU342E, LEU343E, LEU41D, LEU421E, LEU425E, LEU76D, LEU80D, LEU84D, PHE419E, PHE429E, PRO120D, PRO344E, PRO346E, PRO422E, PRO71D, PRO78D, PRO81D, PRO82D, SER418E, SER426E, SER428E, THR122D, THR250D, THR72D, THR83D, TRP73D, TYR119D, VAL424E, VAL74D
• D-L: ALA108D, ALA108L, ALA184D, ALA184L, ARG104D, ARG104L, ARG106D, ARG106L, ARG112D, ARG112L, ARG598D, ARG598L, ARG63D, ARG63L, ASN111D, ASN111L, ASN499D, ASN499L, ASP150D, ASP150L, ASP176D, ASP176L, ASP183D, ASP183L, ASP500D, ASP500L, ASP610D, ASP610L, ASP628D, ASP628L, GLN185D, GLU188D, GLU188L, GLU508D, GLU60D, GLU60L, GLU623D, GLU623L, GLU64D, GLU64L, GLU66D, GLU66L, GLY180D, GLY182D, GLY182L, GLY594D, ILE107D, ILE107L, ILE67D, ILE67L, LEU186D, LEU502D, LEU502L, LYS115L, LYS626D, LYS626L, PHE181D, SER187D, SER58D, SER58L, THR110D, THR110L, THR62D, THR62L, THR65D, THR65L, TRP109D, TRP109L, TYR596D, VAL105L, VAL179D, VAL61D, VAL61L
• E-F: ALA152E, ALA229F, ALA420F, ALA45E, ARG101F, ARG255E, ARG259E, ARG345F, ARG430F, ARG431F, ARG70E, ARG75E, ASN257E, ASP224F, ASP225F, ASP228F, ASP249E, ASP251E, ASP253E, GLN79E, GLU118E, GLU226F, GLU227F, GLU252E, GLU423F, GLY231F, GLY254E, GLY258E, GLY39E, GLY427F, HIS77E, LEU230F, LEU232F, LEU256E, LEU260E, LEU342F, LEU343F, LEU41E, LEU421F, LEU425F, LEU76E, LEU80E, LEU84E, PHE419F, PHE429F, PRO120E, PRO147E, PRO344F, PRO346F, PRO422F, PRO71E, PRO78E, PRO81E, PRO82E, SER418F, SER426F, SER428F, THR122E, THR250E, THR72E, THR83E, TRP73E, TYR119E, VAL424F, VAL74E
• E-K: ALA108E, ALA108K, ALA152E, ALA152K, ALA153E, ALA153K, ALA156E, ALA156K, ALA175E, ALA175K, ALA178E, ALA178K, ALA184E, ALA184K, ALA204E, ALA204K, ALA595E, ALA595K, ALA624E, ALA624K, ARG104E, ARG104K, ARG106E, ARG106K, ARG112E, ARG112K, ARG209E, ARG209K, ARG598E, ARG598K, ARG615E, ARG615K, ARG63E, ARG63K, ASN111E, ASN111K, ASN148E, ASN148K, ASN171E, ASN171K, ASN177E, ASN177K, ASN206E, ASN206K, ASN211E, ASN211K, ASN499E, ASN499K, ASP150E, ASP150K, ASP172E, ASP172K, ASP176E, ASP176K, ASP183E, ASP183K, ASP192E, ASP500E, ASP500K, ASP610E, ASP610K, ASP628E, ASP628K, GLN185E, GLN185K, GLU188E, GLU188K, GLU508E, GLU508K, GLU60E, GLU60K, GLU623E, GLU623K, GLU64E, GLU64K, GLU66E, GLU66K, GLY168E, GLY168K, GLY169E, GLY169K, GLY170E, GLY170K, GLY173E, GLY173K, GLY180E, GLY180K, GLY182E, GLY182K, GLY501E, GLY501K, GLY503E, GLY503K, GLY594E, GLY594K, GLY597E, GLY597K, GLY612E, GLY612K, HIS456K, ILE107E, ILE107K, ILE207E, ILE207K, ILE67E, ILE67K, LEU154E, LEU154K, LEU186E, LEU186K, LEU502E, LEU502K, LEU625E, LEU625K, LYS115E, LYS115K, LYS149E, LYS149K, LYS276E, LYS276K, LYS626E, LYS626K, MET205E, MET205K, MET600E, MET600K, MET611E, MET611K, MET614E, MET614K, MET620E, MET620K, PHE181E, PHE181K, PHE498E, PHE498K, PHE504E, PHE599E, PHE599K, PHE617E, PHE617K, PHE627E, PHE627K, PRO155E, PRO155K, PRO190E, PRO190K, PRO616E, PRO616K, PRO621E, PRO621K, PRO622E, PRO622K, SER123E, SER123K, SER158E, SER158K, SER187E, SER187K, THR110E, THR110K, THR167E, THR167K, THR497E, THR497K, THR505E, THR505K, THR62E, THR62K, THR65E, THR65K, TRP109E, TRP109K, TRP157E, TRP157K, TRP174E, TRP174K, TRP210E, TRP210K, TYR189E, TYR189K, TYR596E, TYR596K, VAL105E, VAL105K, VAL151E, VAL151K, VAL159E, VAL159K, VAL179E, VAL179K, VAL618E, VAL618K, VAL619E, VAL619K, VAL61E, VAL61K
• F-J: ALA108F, ALA108J, ALA152F, ALA152J, ALA153F, ALA153J, ALA156F, ALA156J, ALA175F, ALA175J, ALA178F, ALA178J, ALA184F, ALA184J, ALA204F, ALA204J, ALA595F, ALA595J, ALA624F, ALA624J, ARG104F, ARG104J, ARG106F, ARG106J, ARG112F, ARG112J, ARG209F, ARG209J, ARG598F, ARG598J, ARG615F, ARG615J, ARG63F, ARG63J, ASN111F, ASN111J, ASN148F, ASN148J, ASN171F, ASN171J, ASN177F, ASN177J, ASN206F, ASN206J, ASN211F, ASN211J, ASN499F, ASN499J, ASP150F, ASP150J, ASP172F, ASP172J, ASP176F, ASP176J, ASP183F, ASP183J, ASP500F, ASP500J, ASP610F, ASP610J, ASP628F, ASP628J, GLN185F, GLN185J, GLU188F, GLU188J, GLU508F, GLU508J, GLU60F, GLU60J, GLU623F, GLU623J, GLU64F, GLU64J, GLU66F, GLU66J, GLY168F, GLY168J, GLY169F, GLY169J, GLY170F, GLY170J, GLY173F, GLY173J, GLY180F, GLY180J, GLY182F, GLY182J, GLY501F, GLY501J, GLY503F, GLY503J, GLY594F, GLY594J, GLY597F, GLY597J, GLY612F, GLY612J, ILE107F, ILE107J, ILE207F, ILE207J, ILE67F, ILE67J, LEU154F, LEU154J, LEU186F, LEU186J, LEU502F, LEU502J, LEU625F, LEU625J, LYS115F, LYS115J, LYS149F, LYS149J, LYS276F, LYS276J, LYS626F, LYS626J, MET205F, MET205J, MET600F, MET600J, MET611F, MET611J, MET614F, MET614J, MET620F, MET620J, PHE181F, PHE181J, PHE498F, PHE498J, PHE504J, PHE599F, PHE599J, PHE617F, PHE617J, PHE627F, PHE627J, PRO155F, PRO155J, PRO190F, PRO190J, PRO616F, PRO616J, PRO621F, PRO621J, PRO622F, PRO622J, SER123F, SER123J, SER158F, SER158J, SER187F, SER187J, SER58J, THR110F, THR110J, THR167F, THR167J, THR497F, THR497J, THR505F, THR505J, THR62F, THR62J, THR65F, THR65J, TRP109F, TRP109J, TRP157F, TRP157J, TRP174F, TRP174J, TRP210F, TRP210J, TYR189F, TYR189J, TYR596F, TYR596J, VAL105F, VAL105J, VAL151F, VAL151J, VAL159F, VAL159J, VAL179F, VAL179J, VAL618F, VAL618J, VAL619F, VAL619J, VAL61F, VAL61J
• G-H: ALA229H, ALA420H, ALA45G, ARG101H, ARG255G, ARG259G, ARG292G, ARG345H, ARG430H, ARG431H, ARG70G, ARG75G, ASN257G, ASP224H, ASP225H, ASP228H, ASP249G, ASP251G, ASP253G, GLN79G, GLU118G, GLU226H, GLU227H, GLU252G, GLU423H, GLY231H, GLY254G, GLY258G, GLY39G, GLY427H, GLY90G, HIS77G, LEU230H, LEU232H, LEU256G, LEU342H, LEU343H, LEU41G, LEU421H, LEU425H, LEU76G, LEU80G, LEU84G, PHE419H, PHE429H, PRO120G, PRO344H, PRO346H, PRO422H, PRO47G, PRO71G, PRO78G, PRO81G, PRO82G, SER418H, SER426H, SER428H, THR122G, THR250G, THR72G, THR83G, TRP73G, TYR119G, VAL424H, VAL74G
• G-L: ALA229G, ALA420G, ALA45L, ALA46L, ARG101G, ARG255L, ARG345G, ARG430G, ARG70L, ARG75L, ASP224G, ASP225G, ASP228G, ASP251L, ASP253L, GLN79L, GLU118L, GLU226G, GLU227G, GLU423G, GLY231G, GLY39L, GLY427G, GLY90L, HIS77L, LEU230G, LEU232G, LEU342G, LEU343G, LEU41L, LEU421G, LEU425G, LEU76L, LEU80L, LEU84L, PHE419G, PHE429G, PRO344G, PRO346G, PRO422G, PRO71L, PRO78L, PRO81L, PRO82L, SER418G, SER426G, SER428G, THR72L, THR83L, TRP73L, VAL424G, VAL74L
• H-I: ALA229I, ALA420I, ALA45H, ARG101I, ARG255H, ARG259H, ARG292H, ARG345I, ARG430I, ARG431I, ARG70H, ARG75H, ASN257H, ASP224I, ASP225I, ASP228I, ASP249H, ASP251H, ASP253H, GLN79H, GLU118H, GLU226I, GLU227I, GLU252H, GLU423I, GLY231I, GLY254H, GLY258H, GLY39H, GLY427I, GLY90H, HIS77H, LEU230I, LEU232I, LEU256H, LEU342I, LEU343I, LEU41H, LEU421I, LEU425I, LEU76H, LEU80H, LEU84H, PHE419I, PHE429I, PRO120H, PRO147H, PRO344I, PRO346I, PRO422I, PRO71H, PRO78H, PRO81H, PRO82H, SER418I, SER426I, SER428I, THR122H, THR250H, THR72H, THR83H, TRP73H, TYR119H, VAL424I, VAL74H
• I-J: ALA229J, ALA420J, ALA45I, ARG101J, ARG142I, ARG255I, ARG259I, ARG292I, ARG345J, ARG430J, ARG431J, ARG70I, ARG75I, ASN257I, ASP224J, ASP225J, ASP228J, ASP249I, ASP251I, ASP253I, GLN79I, GLU118I, GLU226J, GLU227J, GLU252I, GLU423J, GLY231J, GLY254I, GLY258I, GLY39I, GLY427J, GLY90I, HIS77I, LEU230J, LEU232J, LEU256I, LEU342J, LEU343J, LEU41I, LEU421J, LEU425J, LEU76I, LEU80I, LEU84I, PHE419J, PHE429J, PRO120I, PRO147I, PRO344J, PRO346J, PRO38I, PRO422J, PRO71I, PRO78I, PRO81I, PRO82I, SER418J, SER426J, SER428J, THR122I, THR250I, THR72I, THR83I, TRP73I, TYR119I, VAL424J, VAL74I
• J-K: ALA152J, ALA229K, ALA420K, ALA45J, ARG101K, ARG255J, ARG259J, ARG292J, ARG345K, ARG430K, ARG431K, ARG70J, ARG75J, ASN257J, ASP224K, ASP225K, ASP228K, ASP249J, ASP251J, ASP253J, GLN79J, GLU118J, GLU226K, GLU227K, GLU252J, GLU423K, GLY231K, GLY254J, GLY258J, GLY39J, GLY427K, GLY90J, HIS77J, LEU230K, LEU232K, LEU256J, LEU260J, LEU342K, LEU343K, LEU41J, LEU421K, LEU425K, LEU76J, LEU80J, LEU84J, PHE419K, PHE429K, PRO120J, PRO147J, PRO344K, PRO346K, PRO38J, PRO422K, PRO71J, PRO78J, PRO81J, PRO82J, SER418K, SER426K, SER428K, THR122J, THR250J, THR72J, THR83J, TRP73J, TYR119J, VAL424K, VAL74J
• K-L: ARG101L, ARG255K, ARG345L, ARG430L, ARG70K, ASP225L, ASP251K, ASP253K, GLU118K, GLU423L, TRP73K