3GOK

binding site mapping of protein ligands

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: F-G
  • Int. Res.: 58
  • Norm. En. per Res.: -4.153
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-15.0173	-61.9222	-172.029	-248.9686	90	5	3	8021	4	28	23
A-C	-13.1426	-54.8864	-192.356	-260.3849	95	10	3	8912	4	29	23
A-D	0.0	0.0	-15.6849	-15.6849	27	0	0	1217	0	0	6
A-F	-21.4259	-4.0794	-118.568	-144.0733	51	3	6	5805	2	16	19
A-G	-35.7009	-1.5942	-130.425	-167.7201	55	8	6	6712	1	18	21
B-C	-5.9019	-60.0242	-194.884	-260.8102	91	7	3	9246	4	29	23
B-G	0.0	0.0	-7.16	-7.16	28	0	0	845	0	0	4
B-I	-56.8815	-4.0235	-174.727	-235.632	57	21	6	7443	1	18	20
B-J	-40.9627	-2.3012	-142.187	-185.4508	55	14	7	7007	1	17	20
C-D	-31.1178	-4.0238	-142.396	-177.5376	55	7	7	6426	2	18	20
C-J	0.0	0.0	-11.4429	-11.4429	24	0	0	1090	0	0	6
C-L	-36.431	-0.6754	-146.225	-183.3314	54	2	6	6474	1	16	21
D-E	-33.1588	-57.6611	-132.655	-223.4749	73	7	1	6345	4	27	23
D-F	-24.1932	-59.4896	-186.734	-270.4168	96	10	2	8878	4	27	23
D-L	-47.0332	-2.5336	-172.59	-222.1568	55	8	6	7260	1	16	21
E-F	-15.6549	-20.585	-165.876	-202.1159	89	6	2	8299	3	28	24
E-H	-53.9423	-3.1577	-185.011	-242.111	59	11	6	7539	2	17	21
E-K	-57.9729	-2.1308	-182.992	-243.0957	59	13	6	7700	1	17	21
E-L	0.0	0.0	-3.4117	-3.4117	24	0	0	695	0	0	5
F-G	-60.0101	-1.3586	-179.508	-240.8766	58	17	6	7737	1	17	21
F-H	0.0	0.0	-3.3255	-3.3255	24	0	0	658	0	0	5
G-H	-28.1941	-12.7623	-166.88	-207.8365	90	2	3	8225	4	28	24
G-I	-14.927	-54.3143	-170.541	-239.7822	91	9	2	8087	4	28	23
H-I	-10.557	-60.189	-188.085	-258.831	90	4	3	8727	4	27	23
H-K	-29.0653	-2.5492	-124.4	-156.0145	53	4	6	5970	1	17	20
I-J	-37.0703	-3.7182	-140.976	-181.7645	56	10	7	6415	2	18	20
I-K	0.0	0.0	-11.536	-11.536	27	0	0	1064	0	0	4
J-K	-14.3084	-57.6872	-152.02	-224.0155	74	4	1	6738	4	28	23
J-L	-4.6819	-62.4687	-192.66	-259.8106	96	14	3	9136	4	28	23
K-L	-14.2262	-56.6012	-186.486	-257.3134	92	5	3	8706	4	28	23

Interface residues

• A-B: ALA231A, ARG185B, ARG278B, ARG280B, ARG303B, ARG313A, ARG313B, ASN181A, ASN304A, ASN304B, ASN321A, ASP186B, ASP241B, ASP245B, CYS244B, GLN175A, GLN283B, GLN312A, GLN312B, GLU190B, GLU233A, GLU238A, GLU285B, GLU309A, GLU309B, GLU318A, GLY236A, GLY282B, HIS178A, HIS47A, ILE174A, ILE180A, ILE252B, ILE255B, ILE271B, ILE279B, ILE316A, LEU177A, LEU192B, LEU235A, LEU249B, LEU305B, LEU306B, LYS188B, LYS239A, LYS242A, LYS242B, LYS276B, LYS307A, LYS307B, MET246B, MET275B, MET281B, MET314A, MET320A, MET326A, PHE147B, PHE210B, PHE263B, PHE46A, PRO189B, PRO232A, PRO237A, PRO261B, PRO262B, PRO310A, PRO310B, SER179A, SER243A, SER243B, SER248B, THR214A, THR215A, THR277B, THR308B, THR311A, THR311B, THR315A, THR317A, TRP247B, TRP349B, TYR176A, TYR229A, TYR240A, TYR240B, TYR284B, VAL187B, VAL230A, VAL234A, VAL251B
• A-C: ALA231C, ARG185A, ARG278A, ARG280A, ARG303A, ARG313A, ARG313C, ARG348A, ASN181C, ASN191A, ASN304A, ASN304C, ASN321C, ASP186A, ASP241A, ASP245A, CYS244A, GLN175C, GLN283A, GLN312A, GLN312C, GLU190A, GLU233C, GLU238C, GLU285A, GLU309A, GLU309C, GLU318C, GLU350A, GLY171C, GLY236C, GLY274A, GLY282A, HIS178C, ILE174C, ILE180C, ILE182C, ILE252A, ILE255A, ILE279A, ILE316C, ILE74A, LEU177C, LEU235C, LEU305A, LEU306A, LYS188A, LYS239C, LYS242A, LYS242C, LYS276A, LYS307A, LYS307C, MET246A, MET275A, MET281A, MET314C, MET320C, MET326C, PHE210A, PHE263A, PRO189A, PRO227C, PRO232C, PRO237C, PRO261A, PRO262A, PRO310A, PRO310C, SER179C, SER243A, SER243C, SER248A, SER265A, THR214C, THR215C, THR277A, THR308A, THR311A, THR311C, THR315C, THR317C, TRP247A, TRP349A, TYR176C, TYR228C, TYR229C, TYR240A, TYR240C, TYR264A, TYR284A, VAL187A, VAL230C, VAL234C, VAL251A
• A-D: ALA129A, ALA129D, ARG131A, ARG131D, ARG280A, ARG280D, ASN266D, GLN96A, GLN96D, GLY130A, GLY130D, GLY274A, GLY274D, LYS276A, LYS276D, LYS77A, LYS77D, MET94A, MET94D, PRO273A, PRO273D, SER272A, SER272D, THR277A, THR277D, TYR128A, TYR128D
• A-F: ALA111F, ALA129A, ALA58A, ARG110F, ARG131A, ASN126A, ASN181F, ASN57A, ASP61A, CYS133A, GLN113F, GLN53A, GLN53F, GLU106F, GLU125A, GLU213F, GLY130A, GLY51F, HIS47F, ILE180F, ILE182F, ILE54A, ILE54F, ILE59A, ILE60A, ILE81A, LEU107F, LEU127A, LEU135A, LEU52F, LEU79A, LEU92A, LYS132A, LYS49F, LYS55A, LYS56A, LYS56F, MET94A, PHE46F, SER112F, SER179F, SER50F, SER67A, THR215F, THR66A, TRP109F, TYR124A, TYR128A, TYR176F, VAL48F, VAL65A
• A-G: ALA111A, ALA129G, ALA58G, ARG102A, ARG110A, ARG131G, ASN126G, ASN181A, ASN57G, ASP61G, ASP97G, CYS133G, GLN113A, GLN53A, GLN53G, GLN96G, GLU106A, GLU125G, GLU213A, GLY130G, GLY51A, HIS108A, HIS47A, ILE180A, ILE182A, ILE54A, ILE54G, ILE59G, ILE60G, ILE81G, LEU107A, LEU127G, LEU135G, LEU52A, LEU79G, LEU92G, LYS132G, LYS49A, LYS55G, LYS56A, LYS56G, MET94G, PHE46A, SER112A, SER179A, SER50A, SER67G, THR215A, THR66G, TRP109A, TYR124G, TYR128G, TYR176A, VAL48A, VAL65G
• B-C: ALA231B, ARG185C, ARG278C, ARG280C, ARG303C, ARG313B, ARG313C, ARG348C, ASN181B, ASN304B, ASN304C, ASN321B, ASP186C, ASP241C, ASP245C, CYS244C, GLN175B, GLN283C, GLN312B, GLN312C, GLU190C, GLU233B, GLU238B, GLU285C, GLU309B, GLU309C, GLU318B, GLU350C, GLY236B, GLY282C, HIS178B, ILE174B, ILE180B, ILE252C, ILE255C, ILE279C, ILE316B, ILE74C, LEU177B, LEU235B, LEU305C, LEU306C, LYS188C, LYS239B, LYS242B, LYS242C, LYS276C, LYS307B, LYS307C, MET246C, MET275C, MET281C, MET314B, MET320B, MET326B, PHE147C, PHE210C, PHE263C, PRO189C, PRO227B, PRO232B, PRO237B, PRO261C, PRO262C, PRO310B, PRO310C, SER179B, SER243B, SER243C, SER248C, THR214B, THR215B, THR277C, THR308C, THR311B, THR311C, THR315B, THR317B, TRP247C, TRP349C, TYR176B, TYR228B, TYR229B, TYR240B, TYR240C, TYR264C, TYR284C, VAL187C, VAL230B, VAL234B, VAL251C
• B-G: ALA129B, ALA129G, ARG131B, ARG131G, ARG280B, ARG280G, ASN266G, GLN96B, GLN96G, GLY274B, GLY274G, ILE271B, LEU79G, LYS276B, LYS276G, LYS77B, LYS77G, MET94B, MET94G, PRO273B, PRO273G, SER272B, SER272G, SER67G, THR277B, THR277G, TYR128B, TYR128G
• B-I: ALA111I, ALA129B, ALA58B, ARG110I, ARG131B, ASN126B, ASN181I, ASN57B, ASP61B, ASP97B, CYS114I, CYS133B, GLN113I, GLN53B, GLN53I, GLN96B, GLU106I, GLU125B, GLU213I, GLY130B, GLY51I, HIS108I, HIS47I, ILE180I, ILE182I, ILE54B, ILE54I, ILE59B, ILE60B, ILE81B, LEU127B, LEU135B, LEU52I, LEU79B, LEU92B, LYS132B, LYS49I, LYS55B, LYS56B, LYS56I, LYS77B, LYS93B, MET94B, PHE46I, SER112I, SER179I, SER50I, SER67B, THR215I, THR66B, TRP109I, TYR124B, TYR128B, TYR176I, TYR63B, VAL48I, VAL65B
• B-J: ALA111B, ALA129J, ALA58J, ARG110B, ARG131J, ASN126J, ASN181B, ASN57J, ASP61J, ASP62J, CYS133J, GLN113B, GLN53B, GLN53J, GLU106B, GLU125J, GLU213B, GLY130J, GLY51B, HIS108B, HIS47B, ILE180B, ILE182B, ILE54B, ILE54J, ILE59J, ILE60J, ILE81J, LEU107B, LEU127J, LEU135J, LEU52B, LEU79J, LEU92J, LYS132J, LYS49B, LYS55J, LYS56B, LYS56J, LYS64J, MET94J, PHE46B, SER112B, SER179B, SER50B, SER67J, THR215B, THR66J, TRP109B, TYR124J, TYR128J, TYR176B, TYR63J, VAL48B, VAL65J
• C-D: ALA111C, ALA129D, ALA58D, ARG102C, ARG110C, ARG131D, ASN126D, ASN181C, ASN57D, ASP61D, ASP62D, ASP97D, CYS133D, GLN113C, GLN53C, GLN53D, GLU106C, GLU125D, GLU213C, GLY130D, GLY51C, HIS108C, HIS47C, ILE180C, ILE182C, ILE54C, ILE54D, ILE59D, ILE60D, ILE81D, LEU107C, LEU127D, LEU135D, LEU52C, LEU79D, LEU92D, LYS132D, LYS49C, LYS55D, LYS56C, LYS56D, MET94D, PHE46C, SER112C, SER179C, SER50C, SER67D, THR215C, THR66D, TRP109C, TYR124D, TYR128D, TYR176C, VAL48C, VAL65D
• C-J: ALA129C, ALA129J, ARG131C, ARG131J, ARG280C, ARG280J, GLN96C, GLN96J, GLY130J, GLY274C, GLY274J, LYS276C, LYS276J, LYS77C, LYS77J, MET94C, MET94J, PRO273C, PRO273J, SER272J, THR277C, THR277J, TYR128C, TYR128J
• C-L: ALA111L, ALA129C, ALA58C, ARG102L, ARG110L, ARG131C, ASN126C, ASN181L, ASN57C, ASP61C, CYS133C, GLN113L, GLN53C, GLN53L, GLN96C, GLU106L, GLU125C, GLU213L, GLY130C, GLY51L, HIS108L, HIS47L, ILE180L, ILE182L, ILE54C, ILE54L, ILE59C, ILE60C, ILE81C, LEU127C, LEU135C, LEU52L, LEU79C, LEU92C, LYS132C, LYS49L, LYS55C, LYS56C, LYS56L, LYS77C, MET94C, PHE46L, SER112L, SER179L, SER50L, SER67C, THR215L, THR66C, TRP109L, TYR124C, TYR128C, TYR176L, VAL48L, VAL65C
• D-E: ALA231D, ARG185E, ARG278E, ARG280E, ARG303E, ARG313D, ARG313E, ASN181D, ASN304D, ASN321D, ASP241E, ASP245E, CYS244E, GLN175D, GLN283E, GLN312D, GLN312E, GLU233D, GLU238D, GLU285E, GLU309D, GLU309E, GLU318D, GLY236D, GLY282E, HIS178D, ILE174D, ILE180D, ILE271E, ILE279E, ILE316D, LEU177D, LEU235D, LEU305E, LEU306E, LYS239D, LYS242D, LYS276E, LYS307D, LYS307E, MET246E, MET275E, MET281E, MET314D, MET320D, MET326D, PHE210E, PHE263E, PHE46D, PRO232D, PRO237D, PRO273E, PRO310D, PRO310E, SER179D, SER243D, SER243E, SER248E, THR214D, THR215D, THR277E, THR308E, THR311D, THR311E, THR315D, THR317D, TRP247E, TYR176D, TYR240D, TYR240E, TYR284E, VAL234D, VAL251E
• D-F: ALA231F, ARG185D, ARG278D, ARG280D, ARG303D, ARG313D, ARG313F, ARG348D, ASN181F, ASN191D, ASN266D, ASN304D, ASN304F, ASN321F, ASP186D, ASP241D, ASP245D, CYS244D, GLN175F, GLN283D, GLN312D, GLN312F, GLU190D, GLU233F, GLU238F, GLU285D, GLU309D, GLU309F, GLU318F, GLU350D, GLY236F, GLY274D, GLY282D, HIS178F, ILE174F, ILE180F, ILE252D, ILE255D, ILE279D, ILE316F, ILE74D, LEU177F, LEU235F, LEU249D, LEU305D, LEU306D, LYS188D, LYS239F, LYS242D, LYS242F, LYS276D, LYS307D, LYS307F, MET246D, MET275D, MET281D, MET314F, MET320F, MET326F, PHE210D, PHE263D, PHE46F, PRO189D, PRO227F, PRO232F, PRO237F, PRO261D, PRO262D, PRO310D, PRO310F, SER179F, SER243D, SER243F, SER248D, SER265D, THR214F, THR215F, THR277D, THR308D, THR311D, THR311F, THR315F, THR317F, TRP247D, TRP349D, TYR176F, TYR228F, TYR229F, TYR240D, TYR240F, TYR264D, TYR284D, VAL187D, VAL230F, VAL234F, VAL251D
• D-L: ALA111D, ALA129L, ALA58L, ARG110D, ARG131L, ASN126L, ASN181D, ASN57L, ASP61L, CYS133L, GLN113D, GLN53D, GLN53L, GLN96L, GLU106D, GLU125L, GLU213D, GLY130L, GLY51D, HIS108D, HIS47D, ILE180D, ILE182D, ILE54D, ILE54L, ILE59L, ILE60L, ILE81L, LEU107D, LEU127L, LEU135L, LEU52D, LEU79L, LEU92L, LYS132L, LYS49D, LYS55L, LYS56D, LYS56L, LYS77L, MET94L, PHE46D, SER112D, SER179D, SER50D, SER67L, THR215D, THR66L, TRP109D, TYR124L, TYR128L, TYR176D, TYR63L, VAL48D, VAL65L
• E-F: ALA231E, ARG185F, ARG278F, ARG280F, ARG303F, ARG313E, ARG313F, ARG348F, ASN181E, ASN191F, ASN304E, ASN304F, ASN321E, ASP186F, ASP241F, ASP245F, CYS244F, GLN175E, GLN283F, GLN312E, GLN312F, GLU190F, GLU233E, GLU238E, GLU285F, GLU309E, GLU309F, GLU318E, GLU350F, GLY236E, GLY282F, HIS178E, ILE174E, ILE180E, ILE252F, ILE255F, ILE279F, ILE316E, ILE74F, LEU177E, LEU235E, LEU306F, LYS188F, LYS239E, LYS242E, LYS276F, LYS307E, LYS307F, MET275F, MET281F, MET314E, MET320E, MET326E, PHE210F, PHE263F, PRO189F, PRO227E, PRO232E, PRO237E, PRO261F, PRO262F, PRO273F, PRO310E, PRO310F, SER179E, SER243E, SER243F, SER248F, THR214E, THR215E, THR277F, THR308F, THR311E, THR311F, THR315E, THR317E, TRP247F, TRP349F, TYR176E, TYR228E, TYR229E, TYR240E, TYR240F, TYR264F, TYR284F, VAL187F, VAL230E, VAL234E, VAL251F
• E-H: ALA111E, ALA129H, ALA58H, ARG102E, ARG110E, ARG131H, ASN126H, ASN181E, ASN57H, ASP61H, ASP97H, CYS114E, CYS133H, GLN113E, GLN53E, GLN53H, GLN96H, GLU106E, GLU125H, GLU213E, GLY130H, GLY51E, HIS108E, HIS47E, ILE180E, ILE182E, ILE54E, ILE54H, ILE59H, ILE60H, ILE81H, LEU107E, LEU127H, LEU135H, LEU52E, LEU79H, LEU92H, LYS132H, LYS49E, LYS55H, LYS56E, LYS56H, LYS77H, MET94H, PHE46E, SER112E, SER179E, SER50E, SER67H, THR215E, THR66H, TRP109E, TYR124H, TYR128H, TYR176E, TYR63H, VAL105E, VAL48E, VAL65H
• E-K: ALA111K, ALA129E, ALA58E, ARG102K, ARG110K, ARG131E, ASN126E, ASN181K, ASN57E, ASP61E, ASP97E, CYS114K, CYS133E, GLN113K, GLN53E, GLN53K, GLN96E, GLU106K, GLU125E, GLU213K, GLY130E, GLY51K, HIS108K, HIS47K, ILE180K, ILE182K, ILE54E, ILE54K, ILE59E, ILE60E, ILE81E, LEU107K, LEU127E, LEU135E, LEU52K, LEU79E, LEU92E, LYS132E, LYS49K, LYS55E, LYS56E, LYS56K, LYS77E, MET94E, PHE46K, SER112K, SER179K, SER50K, SER67E, THR215K, THR66E, TRP109K, TYR124E, TYR128E, TYR176K, TYR63E, VAL105K, VAL48K, VAL65E
• E-L: ALA129E, ALA129L, ARG131E, ARG131L, ARG280E, ARG280L, GLN96E, GLN96L, GLY274E, GLY274L, ILE271E, LYS276E, LYS276L, LYS77E, LYS77L, MET94E, MET94L, PRO273E, PRO273L, SER272E, THR277E, THR277L, TYR128E, TYR128L
• F-G: ALA111G, ALA129F, ALA58F, ARG102G, ARG110G, ARG131F, ASN126F, ASN181G, ASN57F, ASP61F, ASP97F, CYS114G, CYS133F, GLN113G, GLN53F, GLN53G, GLN96F, GLU106G, GLU125F, GLU213G, GLY130F, GLY51G, HIS108G, HIS47G, ILE180G, ILE182G, ILE54F, ILE54G, ILE59F, ILE60F, ILE81F, LEU107G, LEU127F, LEU135F, LEU52G, LEU79F, LEU92F, LYS132F, LYS49G, LYS55F, LYS56F, LYS56G, LYS77F, MET94F, PHE46G, SER112G, SER179G, SER50G, SER67F, THR215G, THR66F, TRP109G, TYR124F, TYR128F, TYR176G, VAL105G, VAL48G, VAL65F
• F-H: ALA129F, ALA129H, ARG131F, ARG131H, ARG280F, ARG280H, GLN96F, GLN96H, GLY274F, GLY274H, ILE271H, LYS276F, LYS276H, LYS77F, LYS77H, MET94F, MET94H, PRO273F, PRO273H, SER272H, THR277F, THR277H, TYR128F, TYR128H
• G-H: ALA231G, ARG185H, ARG278H, ARG280H, ARG303H, ARG313G, ARG313H, ARG348H, ASN181G, ASN304G, ASN304H, ASN321G, ASP186H, ASP241H, ASP245H, CYS244H, GLN175G, GLN283H, GLN312G, GLN312H, GLU190H, GLU233G, GLU238G, GLU285H, GLU309G, GLU309H, GLU318G, GLU350H, GLY236G, GLY282H, HIS178G, HIS47G, ILE174G, ILE180G, ILE252H, ILE255H, ILE271H, ILE279H, ILE316G, LEU177G, LEU235G, LEU306H, LYS188H, LYS239G, LYS242G, LYS276H, LYS307G, LYS307H, MET275H, MET281H, MET314G, MET320G, MET326G, PHE147H, PHE210H, PHE263H, PRO189H, PRO232G, PRO237G, PRO261H, PRO262H, PRO310G, PRO310H, SER179G, SER243G, SER243H, SER248H, SER265H, THR214G, THR215G, THR277H, THR308H, THR311G, THR311H, THR315G, THR317G, TRP247H, TRP349H, TYR176G, TYR228G, TYR229G, TYR240G, TYR240H, TYR260H, TYR264H, TYR284H, VAL187H, VAL230G, VAL234G, VAL251H
• G-I: ALA231I, ARG185G, ARG278G, ARG280G, ARG303G, ARG313G, ARG313I, ARG348G, ASN181I, ASN191G, ASN304I, ASN321I, ASP186G, ASP241G, ASP245G, CYS244G, GLN175I, GLN283G, GLN312G, GLN312I, GLU190G, GLU233I, GLU238I, GLU285G, GLU309G, GLU309I, GLU318I, GLU350G, GLY236I, GLY274G, GLY282G, HIS178I, ILE174I, ILE180I, ILE252G, ILE255G, ILE279G, ILE316I, ILE74G, LEU177I, LEU235I, LEU306G, LYS188G, LYS239I, LYS242I, LYS276G, LYS307G, LYS307I, MET246G, MET275G, MET281G, MET314I, MET320I, MET326I, PHE210G, PHE263G, PRO189G, PRO227I, PRO232I, PRO237I, PRO261G, PRO262G, PRO310G, PRO310I, SER179I, SER243G, SER243I, SER248G, SER265G, SER272G, THR214I, THR215I, THR277G, THR308G, THR311G, THR311I, THR315I, THR317I, TRP247G, TRP349G, TYR176I, TYR228I, TYR229I, TYR240G, TYR240I, TYR264G, TYR284G, VAL187G, VAL230I, VAL234I, VAL251G
• H-I: ALA231H, ARG185I, ARG278I, ARG280I, ARG303I, ARG313H, ARG313I, ARG348I, ASN181H, ASN304H, ASN321H, ASP186I, ASP241I, ASP245I, CYS244I, GLN175H, GLN283I, GLN312H, GLN312I, GLU190I, GLU233H, GLU238H, GLU285I, GLU309H, GLU309I, GLU318H, GLU350I, GLY236H, GLY274I, GLY282I, HIS178H, ILE174H, ILE180H, ILE252I, ILE255I, ILE279I, ILE316H, LEU177H, LEU235H, LEU305I, LEU306I, LYS188I, LYS239H, LYS242H, LYS242I, LYS276I, LYS307H, LYS307I, MET246I, MET275I, MET281I, MET314H, MET320H, MET326H, PHE210I, PHE263I, PRO189I, PRO227H, PRO232H, PRO237H, PRO261I, PRO262I, PRO310H, PRO310I, SER179H, SER243H, SER243I, SER248I, THR214H, THR215H, THR277I, THR308I, THR311H, THR311I, THR315H, THR317H, TRP247I, TRP349I, TYR176H, TYR228H, TYR229H, TYR240H, TYR240I, TYR260I, TYR264I, TYR284I, VAL187I, VAL230H, VAL234H, VAL251I
• H-K: ALA111H, ALA129K, ALA58K, ARG102H, ARG110H, ARG131K, ASN126K, ASN181H, ASN57K, ASP61K, CYS133K, GLN113H, GLN53H, GLN53K, GLU106H, GLU125K, GLU213H, GLY130K, GLY51H, HIS108H, HIS47H, ILE180H, ILE182H, ILE54H, ILE54K, ILE59K, ILE60K, ILE81K, LEU107H, LEU127K, LEU135K, LEU52H, LEU79K, LEU92K, LYS132K, LYS49H, LYS55K, LYS56H, LYS56K, MET94K, PHE46H, SER112H, SER179H, SER50H, SER67K, THR215H, THR66K, TRP109H, TYR124K, TYR128K, TYR176H, VAL48H, VAL65K
• I-J: ALA111J, ALA129I, ALA58I, ARG102J, ARG110J, ARG131I, ASN126I, ASN181J, ASN57I, ASP61I, ASP62I, CYS133I, GLN113J, GLN53I, GLN53J, GLU106J, GLU125I, GLU213J, GLY130I, GLY51J, HIS108J, HIS47J, ILE180J, ILE182J, ILE54I, ILE54J, ILE59I, ILE60I, ILE81I, LEU107J, LEU127I, LEU135I, LEU52J, LEU79I, LEU92I, LYS132I, LYS49J, LYS55I, LYS56I, LYS56J, LYS64I, MET94I, PHE46J, SER112J, SER179J, SER50J, SER67I, THR215J, THR66I, TRP109J, TYR124I, TYR128I, TYR176J, TYR63I, VAL48J, VAL65I
• I-K: ALA129I, ALA129K, ARG131I, ARG131K, ARG280I, ARG280K, GLN96I, GLN96K, GLY130I, GLY130K, GLY274I, GLY274K, ILE271K, LYS276I, LYS276K, LYS77I, LYS77K, MET94I, MET94K, PRO273I, PRO273K, SER272K, SER67I, THR277I, THR277K, TYR128I, TYR128K
• J-K: ALA231J, ARG185K, ARG278K, ARG280K, ARG303K, ARG313J, ARG313K, ASN181J, ASN304J, ASN321J, ASP241K, ASP245K, CYS244K, GLN175J, GLN283K, GLN312J, GLN312K, GLU233J, GLU238J, GLU285K, GLU309J, GLU309K, GLU318J, GLY236J, GLY282K, HIS178J, HIS47J, ILE174J, ILE180J, ILE271K, ILE279K, ILE316J, LEU177J, LEU235J, LEU305K, LEU306K, LYS239J, LYS242J, LYS242K, LYS276K, LYS307J, LYS307K, MET246K, MET275K, MET281K, MET314J, MET320J, MET326J, PHE210K, PHE263K, PHE46J, PRO232J, PRO237J, PRO310J, PRO310K, SER179J, SER243J, SER243K, SER248K, THR214J, THR215J, THR277K, THR308K, THR311J, THR311K, THR315J, THR317J, TRP247K, TYR176J, TYR240J, TYR240K, TYR284K, VAL234J, VAL251K
• J-L: ALA231L, ARG185J, ARG278J, ARG280J, ARG303J, ARG313J, ARG313L, ARG348J, ASN181L, ASN304J, ASN304L, ASN321L, ASP186J, ASP241J, ASP245J, CYS244J, GLN175L, GLN283J, GLN312J, GLN312L, GLU190J, GLU233L, GLU238L, GLU285J, GLU309J, GLU309L, GLU318L, GLU350J, GLY171L, GLY236L, GLY274J, GLY282J, HIS178L, ILE174L, ILE180L, ILE182L, ILE252J, ILE255J, ILE279J, ILE316L, ILE74J, LEU177L, LEU235L, LEU249J, LEU305J, LEU306J, LYS188J, LYS239L, LYS242J, LYS242L, LYS276J, LYS307J, LYS307L, MET246J, MET275J, MET281J, MET314L, MET320L, MET326L, PHE210J, PHE263J, PRO189J, PRO227L, PRO232L, PRO237L, PRO261J, PRO262J, PRO310J, PRO310L, SER179L, SER243J, SER243L, SER248J, SER265J, SER272J, THR214L, THR215L, THR277J, THR308J, THR311J, THR311L, THR315L, THR317L, TRP247J, TRP349J, TYR176L, TYR228L, TYR229L, TYR240J, TYR240L, TYR264J, TYR284J, VAL187J, VAL230L, VAL234L, VAL251J
• K-L: ALA231K, ARG185L, ARG278L, ARG280L, ARG303L, ARG313K, ARG313L, ARG348L, ASN181K, ASN191L, ASN304K, ASN304L, ASN321K, ASP186L, ASP241L, ASP245L, CYS244L, GLN175K, GLN283L, GLN312K, GLN312L, GLU190L, GLU233K, GLU238K, GLU285L, GLU309K, GLU309L, GLU318K, GLU350L, GLY236K, GLY282L, HIS178K, ILE174K, ILE180K, ILE252L, ILE255L, ILE279L, ILE316K, ILE74L, LEU177K, LEU235K, LEU305L, LEU306L, LYS188L, LYS239K, LYS242K, LYS242L, LYS276L, LYS307K, LYS307L, MET246L, MET275L, MET281L, MET314K, MET320K, MET326K, PHE147L, PHE210L, PHE263L, PRO189L, PRO227K, PRO232K, PRO237K, PRO261L, PRO262L, PRO310K, PRO310L, SER179K, SER243K, SER243L, SER248L, THR214K, THR215K, THR277L, THR308L, THR311K, THR311L, THR315K, THR317K, TRP247L, TRP349L, TYR176K, TYR228K, TYR229K, TYR240K, TYR240L, TYR264L, TYR284L, VAL187L, VAL230K, VAL234K, VAL251L