3GMH

crystal structure of the mad2 dimer

• Total interactions analyzed: 66
• Total true interactions: 25
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 95
  • Norm. En. per Res.: -3.0181
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-16.5737	-14.3361	-234.592	-265.5018	98	16	4	10879	1	19	15
A-D	-34.6304	-13.0392	-199.495	-247.1646	92	15	9	8945	1	22	25
A-E	0.0	0.0	-22.2167	-22.2167	38	8	1	2360	0	12	10
A-G	0.0	40.5177	-28.9796	11.5381	32	0	0	1491	0	2	6
A-H	-4.6765	0.8889	-62.3641	-66.1517	30	3	0	2800	0	8	4
B-C	-37.5816	-27.6834	-195.671	-260.9361	88	14	9	8697	1	20	19
B-D	0.0	0.0	-6.3972	-6.3972	11	0	0	373	0	1	1
B-G	-7.5658	0.7	-61.6568	-68.5226	30	7	0	3071	0	8	4
B-H	-14.002	8.561	-44.4305	-49.8715	52	16	3	4294	0	8	12
C-D	-16.2957	-14.5199	-230.137	-260.9526	99	12	4	10672	1	19	17
C-K	0.0	22.5046	-19.3519	3.1527	32	0	0	1213	0	2	6
C-L	-6.9841	0.5796	-68.9647	-75.3692	31	7	0	3080	0	8	4
D-K	-7.5189	0.5252	-72.652	-79.6457	31	13	0	3128	0	8	4
D-L	-11.587	3.6487	-82.3332	-90.2715	49	7	3	4138	0	8	11
E-F	-20.913	-12.9954	-261.401	-295.3093	102	28	5	11593	1	21	16
E-H	0.0	0.0	-0.0056	-0.0056	3	0	0	6	0	2	1
E-I	0.0	3.7257	-23.8601	-20.1344	33	0	1	1466	0	3	6
F-I	-13.9306	1.0278	-112.295	-125.1977	54	24	1	5317	0	12	8
F-J	0.0	0.0	-0.5532	-0.5532	11	0	0	129	0	1	2
G-H	-39.3766	-13.2936	-238.352	-291.0222	99	11	4	10868	1	19	17
G-J	-27.5057	-31.5806	-178.646	-237.7323	86	20	7	8590	1	21	21
H-I	-39.7958	-35.3268	-211.601	-286.7236	95	12	9	10194	5	25	24
H-J	0.0	0.0	-2.0807	-2.0807	8	0	0	124	0	0	0
I-J	-39.503	-9.1373	-201.596	-250.2363	101	32	5	11659	1	21	18
K-L	-40.6879	-14.579	-220.447	-275.7139	95	12	4	10398	1	19	16

Interface residues

• A-B: ALA123A, ALA137A, ALA137B, ARG129A, ARG129B, ARG133A, ARG133B, ARG182A, ARG182B, ARG184A, ARG35A, ARG35B, ARG45A, ARG45B, ASP126A, ASP126B, GLN125A, GLN125B, GLN134A, GLN134B, GLN34A, GLN34B, GLN47A, GLN47B, GLU127A, GLU146B, GLU179A, GLU180A, GLU180B, GLU41B, GLU98B, GLY36B, GLY50A, GLY50B, ILE124A, ILE128A, ILE128B, ILE132A, ILE132B, ILE135A, ILE135B, ILE31B, ILE37B, LEU142A, LEU142B, LEU144A, LEU144B, LEU145B, LEU183A, LEU32B, LEU51A, LEU51B, LEU53A, LEU53B, LEU54A, LEU54B, LYS119A, LYS122A, LYS122B, LYS48B, MET196A, PHE141A, PHE141B, PHE186A, PHE26B, PHE43B, PRO143A, PRO143B, PRO202A, PRO39B, SER130A, SER130B, SER185A, SER195A, SER30A, SER30B, SER40B, THR136A, THR136B, THR138A, THR138B, THR140A, THR140B, THR42B, THR52A, THR52B, TRP100B, TYR199A, TYR33A, TYR33B, TYR38B, TYR49A, VAL131A, VAL131B, VAL139A, VAL139B, VAL181A, VAL197A
• A-D: ALA198D, ARG14D, ARG182A, ARG99A, ASN177A, ASN194A, ASN194D, ASN67A, ASP103A, ASP103D, ASP107D, ASP126D, ASP152A, ASP158A, ASP158D, ASP160A, ASP160D, CYS106A, CYS106D, CYS79A, CYS79D, GLN134D, GLN173A, GLN71A, GLN82A, GLN82D, GLU105D, GLU127D, GLU168A, GLU169A, GLU179A, GLU180A, GLU60A, GLY171A, GLY9D, HIS7D, HIS8D, ILE104A, ILE104D, ILE155A, ILE175A, ILE201A, ILE201D, ILE28A, LEU153A, LEU154A, LEU161A, LEU61A, LEU65A, LEU72A, LEU84A, LYS108A, LYS108D, LYS122D, LYS159A, LYS159D, LYS166A, LYS200D, LYS63A, LYS78D, LYS83A, MET196A, MET196D, PHE151A, PHE174A, PRO164A, PRO172A, PRO202D, SER10D, SER170A, SER178A, SER195D, SER80A, SER80D, SER89A, THR12D, THR157A, THR176A, TRP167A, TRP75A, TYR156A, TYR199D, TYR64A, VAL162A, VAL163A, VAL193D, VAL197D, VAL203D, VAL68A, VAL81A, VAL85A, VAL87A
• A-E: ARG45E, ASN29E, ASN66A, ASN66E, ASN67A, ASP58A, ASP58E, GLN47E, GLU22A, GLU41E, GLU60A, GLU70A, ILE62A, ILE62E, LEU54E, LEU59A, LEU59E, LEU65E, LYS63A, LYS63E, LYS73A, PHE26A, PHE26E, PHE43E, SER25A, SER25E, THR42E, THR44A, THR44E, THR56A, THR56E, THR57A, THR57E, VAL46A, VAL46E, VAL55A, VAL55E, VAL69A
• A-G: ASN90A, ASN90G, CYS149A, CYS149G, GLU146A, GLU146G, GLU41A, GLU41G, GLU92A, GLU92G, GLY36A, GLY36G, ILE37A, ILE37G, ILE91A, ILE91G, LEU144A, LEU144G, LEU145A, LEU145G, PRO202A, PRO202G, PRO39A, PRO39G, SER148A, SER148G, SER40A, SER40G, TYR38A, TYR38G, VAL147A, VAL147G
• A-H: ALA123H, ARG129H, ARG45A, ASP126H, GLN121H, GLN125H, GLN34A, GLN47H, GLU22H, GLU41A, GLY50H, ILE124H, ILE19H, LEU51H, LEU54A, LYS122H, LYS48H, PHE43A, PRO39A, SER120H, SER40A, THR42A, THR44A, THR52A, THR57A, TYR33A, TYR49H, VAL139A, VAL46A, VAL55A
• B-C: ALA198B, ARG14B, ARG182C, ARG99C, ASN177C, ASN194B, ASN67C, ASP103B, ASP103C, ASP107B, ASP126B, ASP152C, ASP158B, ASP158C, ASP160B, ASP160C, CYS106B, CYS106C, CYS79B, CYS79C, GLN134B, GLN173C, GLN71C, GLN82B, GLN82C, GLU105B, GLU127B, GLU168C, GLU169C, GLU179C, GLU180C, GLU60C, GLY171C, GLY9B, ILE104B, ILE104C, ILE155C, ILE175C, ILE201B, ILE201C, LEU153C, LEU154C, LEU161C, LEU61C, LEU65C, LEU72C, LEU84C, LYS108B, LYS108C, LYS122B, LYS159B, LYS159C, LYS166C, LYS200B, LYS63C, LYS78B, LYS83C, MET196B, MET196C, PHE151C, PHE174C, PRO164C, PRO172C, PRO202B, SER10B, SER170C, SER178C, SER195B, SER80B, SER80C, SER89C, THR12B, THR157C, THR176C, TRP167C, TRP75C, TYR156C, TYR199B, TYR64C, VAL162C, VAL163C, VAL193B, VAL197B, VAL203B, VAL68C, VAL81C, VAL85C, VAL87C
• B-D: ARG133B, ARG133D, GLY9B, GLY9D, HIS7D, HIS8D, PHE141B, PHE141D, SER10D, THR138B, THR140B
• B-G: ALA123B, ARG129B, ARG45G, ASP126B, GLN121B, GLN125B, GLN34G, GLN47B, GLU22B, GLU41G, GLY50B, ILE124B, ILE19B, LEU51B, LEU54G, LYS122B, LYS48B, PHE43G, PRO39G, SER120B, SER40G, THR42G, THR44G, THR52G, THR57G, TYR33G, TYR49B, VAL139G, VAL46G, VAL55G
• B-H: ARG45B, ARG45H, ASN66B, ASN66H, ASN67B, ASN67H, ASP58B, ASP58H, GLN47B, GLN47H, GLU22H, GLU41B, GLU41H, GLU60B, GLU60H, GLU70B, GLU70H, GLY50B, GLY50H, ILE62B, ILE62H, LEU51B, LEU51H, LEU53B, LEU53H, LEU54B, LEU54H, LEU59B, LEU59H, LEU61B, LEU61H, LYS48B, LYS48H, LYS63B, LYS63H, PHE26H, PHE43B, PHE43H, THR44B, THR44H, THR52B, THR52H, THR57B, THR57H, TYR49B, TYR49H, TYR64B, TYR64H, VAL46B, VAL46H, VAL55B, VAL55H
• C-D: ALA123C, ALA137C, ALA137D, ARG129C, ARG129D, ARG133C, ARG133D, ARG182C, ARG182D, ARG184C, ARG35C, ARG35D, ARG45C, ARG45D, ASN204C, ASP126C, ASP126D, GLN125C, GLN125D, GLN134C, GLN134D, GLN34C, GLN34D, GLN47C, GLU127C, GLU146D, GLU179C, GLU180C, GLU180D, GLU41D, GLU98D, GLY36D, GLY50C, GLY50D, HIS7D, ILE124C, ILE128C, ILE128D, ILE132C, ILE132D, ILE135C, ILE135D, ILE31D, ILE37D, LEU142C, LEU142D, LEU144C, LEU144D, LEU145D, LEU183C, LEU32D, LEU51C, LEU51D, LEU53C, LEU53D, LEU54C, LEU54D, LYS122C, LYS122D, LYS48D, MET196C, PHE141C, PHE141D, PHE186C, PHE26D, PHE43D, PRO143C, PRO143D, PRO202C, PRO39D, SER130C, SER130D, SER185C, SER195C, SER30C, SER30D, SER40D, THR136C, THR136D, THR138C, THR138D, THR140C, THR140D, THR42D, THR52C, THR52D, TRP100D, TYR199C, TYR33C, TYR33D, TYR38D, TYR49C, VAL131C, VAL131D, VAL139C, VAL139D, VAL181C, VAL197C, VAL203C
• C-K: ASN204C, ASN90C, ASN90K, CYS149C, CYS149K, GLU146C, GLU146K, GLU41C, GLU41K, GLU92C, GLU92K, GLY36C, GLY36K, ILE37C, ILE37K, ILE91C, LEU144C, LEU144K, LEU145C, LEU145K, PRO202C, PRO202K, PRO39C, PRO39K, SER148C, SER148K, SER40C, SER40K, TYR38C, TYR38K, VAL147C, VAL147K
• C-L: ALA123L, ARG129L, ARG45C, ASP126L, GLN121L, GLN125L, GLN34C, GLN47L, GLU22L, GLU41C, GLY50L, ILE124L, ILE19L, LEU51L, LEU54C, LYS122L, LYS48L, PHE43C, PRO39C, SER120L, SER40C, THR42C, THR44C, THR52C, THR56C, THR57C, TYR33C, TYR49L, VAL139C, VAL46C, VAL55C
• D-K: ALA123D, ARG129D, ARG45K, ASP126D, GLN121D, GLN125D, GLN34K, GLN47D, GLU22D, GLU41K, GLY50D, ILE124D, ILE19D, LEU51D, LEU54K, LYS122D, LYS48D, PHE43K, PRO39K, SER120D, SER40K, THR42K, THR44K, THR52K, THR56K, THR57K, TYR33K, TYR49D, VAL139K, VAL46K, VAL55K
• D-L: ARG45D, ARG45L, ASN66D, ASN66L, ASN67D, ASN67L, ASP58D, ASP58L, GLN47D, GLN47L, GLU41D, GLU41L, GLU60D, GLU60L, GLY50D, GLY50L, ILE62D, ILE62L, LEU51D, LEU51L, LEU53D, LEU53L, LEU54D, LEU54L, LEU59D, LEU59L, LEU61D, LEU61L, LYS48D, LYS48L, LYS63D, LYS63L, PHE26L, PHE43D, PHE43L, THR44D, THR44L, THR52D, THR52L, THR57D, THR57L, TYR49D, TYR49L, TYR64D, TYR64L, VAL46D, VAL46L, VAL55D, VAL55L
• E-F: ALA123E, ALA137E, ALA137F, ARG129E, ARG129F, ARG133E, ARG133F, ARG182E, ARG182F, ARG184E, ARG35E, ARG35F, ARG45E, ARG45F, ASN204E, ASP126E, ASP126F, GLN125E, GLN125F, GLN134E, GLN134F, GLN34E, GLN34F, GLN47E, GLU127E, GLU127F, GLU146F, GLU179E, GLU180E, GLU41F, GLU98F, GLY36F, GLY50E, GLY50F, ILE124E, ILE128E, ILE128F, ILE132E, ILE132F, ILE135E, ILE135F, ILE201E, ILE31F, ILE37F, LEU142E, LEU142F, LEU144E, LEU144F, LEU145F, LEU183E, LEU32F, LEU51E, LEU51F, LEU53E, LEU53F, LEU54E, LEU54F, LYS122E, LYS122F, LYS48F, MET196E, PHE141E, PHE141F, PHE186E, PHE26F, PHE43F, PRO143E, PRO143F, PRO202E, PRO39F, SER130E, SER130F, SER185E, SER195E, SER30E, SER30F, SER40F, THR136E, THR136F, THR138E, THR138F, THR140E, THR140F, THR42F, THR44F, THR52E, THR52F, TRP100F, TYR199E, TYR33E, TYR33F, TYR38F, TYR49E, TYR49F, VAL131E, VAL131F, VAL139E, VAL139F, VAL181E, VAL197E, VAL203E, VAL46F
• E-H: GLU41E, SER120H, THR57E
• E-I: ARG35E, ARG45E, ASN90I, CYS149I, GLN34E, GLU146E, GLU41E, GLU92I, GLU95I, GLY36E, GLY94I, ILE37E, ILE91I, LEU142E, LEU144E, LEU145E, LEU97I, LYS200I, PRO143E, PRO39E, SER148E, SER148I, SER150I, SER40E, SER93I, THR140E, THR176I, TYR33E, TYR38E, VAL139E, VAL147E, VAL147I, VAL203I
• F-I: ALA123F, ALA17F, ARG129F, ARG35I, ARG45F, ASN90I, ASP58I, CYS149I, GLN121F, GLN125F, GLN47F, GLU146I, GLU18F, GLU22F, GLU41I, GLU60I, GLU92I, GLY36I, GLY50F, ILE124F, ILE128F, ILE19F, ILE37I, ILE62I, ILE88I, ILE91I, LEU144I, LEU145I, LEU32I, LEU51F, LEU53F, LEU59I, LEU61I, LYS122F, LYS48F, PHE26F, PHE43I, PRO39I, SER120F, SER148I, SER150I, SER16F, SER40I, THR109F, THR42I, THR44F, THR52F, THR56I, THR57I, TYR38I, TYR49F, VAL147I, VAL20F, VAL46F
• F-J: ASN66F, GLN121J, GLN47J, GLY50J, ILE62F, LEU59F, LYS48F, LYS48J, THR44F, THR57F, TYR49J
• G-H: ALA123G, ALA137G, ALA137H, ARG129G, ARG129H, ARG133G, ARG133H, ARG182G, ARG182H, ARG184G, ARG35G, ARG35H, ARG45G, ARG45H, ASP126G, ASP126H, GLN125G, GLN125H, GLN134G, GLN134H, GLN34G, GLN34H, GLN47G, GLN47H, GLU127G, GLU146H, GLU179G, GLU180G, GLU41H, GLU98H, GLY36H, GLY50G, GLY50H, ILE124G, ILE128G, ILE128H, ILE132G, ILE132H, ILE135G, ILE135H, ILE201G, ILE31H, ILE37H, LEU142G, LEU142H, LEU144G, LEU144H, LEU145H, LEU183G, LEU32H, LEU51G, LEU51H, LEU53G, LEU53H, LEU54G, LEU54H, LYS122G, LYS122H, LYS48H, MET196G, PHE141G, PHE141H, PHE186G, PHE26H, PHE43H, PRO143G, PRO143H, PRO202G, PRO39H, SER130G, SER130H, SER185G, SER195G, SER30G, SER30H, SER40H, THR136G, THR136H, THR138G, THR138H, THR140G, THR140H, THR42H, THR52G, THR52H, TRP100H, TYR199G, TYR33G, TYR33H, TYR38H, TYR49G, TYR49H, VAL131G, VAL131H, VAL139G, VAL139H, VAL181G, VAL197G, VAL46H
• G-J: ALA123J, ALA198J, ARG14J, ARG182G, ARG99G, ASN177G, ASN194J, ASN67G, ASP103J, ASP107J, ASP126J, ASP152G, ASP158G, ASP158J, ASP160G, ASP160J, CYS106J, CYS79G, CYS79J, GLN134J, GLN173G, GLN71G, GLN82G, GLN82J, GLU105J, GLU127J, GLU168G, GLU169G, GLU179G, GLU180G, GLU60G, GLY171G, GLY94G, GLY9J, ILE104G, ILE104J, ILE155G, ILE175G, ILE201G, ILE201J, ILE28G, LEU153G, LEU154G, LEU161G, LEU61G, LEU65G, LEU72G, LEU84G, LYS108J, LYS122J, LYS159G, LYS159J, LYS166G, LYS200J, LYS63G, LYS83G, MET196G, MET196J, PHE151G, PHE174G, PRO164G, PRO172G, PRO202J, SER10J, SER170G, SER178G, SER195J, SER80G, SER80J, SER89G, THR12J, THR157G, THR176G, TRP167G, TRP75G, TYR156G, TYR199J, TYR64G, VAL163G, VAL197J, VAL203J, VAL68G, VAL81G, VAL85G, VAL87G, VAL96G
• H-I: ALA123H, ALA198H, ALA198I, ARG133H, ARG14H, ARG182I, ARG99I, ASN177I, ASN194H, ASN67I, ASP103H, ASP103I, ASP107H, ASP126H, ASP152I, ASP158H, ASP158I, ASP160H, ASP160I, CYS106H, CYS79H, GLN101I, GLN134H, GLN173I, GLN71I, GLN82H, GLN82I, GLU105H, GLU127H, GLU168I, GLU169I, GLU179I, GLU180I, GLU60I, GLY15H, GLY171I, GLY9H, HIS8H, ILE104H, ILE104I, ILE11H, ILE155I, ILE175I, ILE201H, ILE201I, ILE28I, LEU153I, LEU154I, LEU161H, LEU161I, LEU61I, LEU65I, LEU72I, LEU84I, LYS108H, LYS122H, LYS159H, LYS159I, LYS166I, LYS200H, LYS63I, LYS83I, MET196H, MET196I, PHE151I, PHE174I, PRO164I, PRO172I, PRO202H, SER10H, SER130H, SER170I, SER178I, SER195H, SER80I, SER89I, THR12H, THR157I, THR176I, TRP167I, TRP75I, TYR156I, TYR199H, TYR199I, TYR64I, VAL162I, VAL163I, VAL197H, VAL203H, VAL203I, VAL68I, VAL69I, VAL81I, VAL85I, VAL87I
• H-J: ARG133H, ARG133J, GLY9H, GLY9J, HIS8H, PHE141H, PHE141J, THR140J
• I-J: ALA123I, ALA137I, ALA137J, ARG129I, ARG129J, ARG133I, ARG133J, ARG182I, ARG182J, ARG184I, ARG35I, ARG35J, ARG45I, ARG45J, ASP126I, ASP126J, GLN121J, GLN125I, GLN125J, GLN134I, GLN134J, GLN34I, GLN34J, GLN47I, GLN47J, GLU127I, GLU146J, GLU179I, GLU180I, GLU41J, GLY36J, GLY50I, GLY50J, ILE128I, ILE128J, ILE132I, ILE132J, ILE135I, ILE135J, ILE31I, ILE31J, ILE37I, ILE37J, LEU142I, LEU142J, LEU144I, LEU144J, LEU145I, LEU145J, LEU183I, LEU32J, LEU51I, LEU51J, LEU53I, LEU53J, LEU54I, LEU54J, LYS122I, LYS122J, MET196I, PHE141I, PHE141J, PHE186I, PHE43J, PRO143I, PRO143J, PRO202I, PRO39J, SER130I, SER130J, SER185I, SER195I, SER30I, SER30J, SER40J, THR136I, THR136J, THR138I, THR138J, THR140I, THR140J, THR42J, THR44J, THR52I, THR52J, TRP100I, TRP100J, TYR199I, TYR33I, TYR33J, TYR38J, TYR49I, TYR49J, VAL131I, VAL131J, VAL139I, VAL139J, VAL181I, VAL197I, VAL203I, VAL46J
• K-L: ALA123K, ALA137K, ALA137L, ARG129K, ARG129L, ARG133K, ARG133L, ARG182K, ARG182L, ARG184K, ARG35K, ARG35L, ARG45K, ARG45L, ASP126K, ASP126L, GLN125K, GLN125L, GLN134K, GLN134L, GLN34K, GLN34L, GLN47L, GLU127K, GLU146L, GLU179K, GLU180K, GLU41L, GLU98L, GLY36L, GLY50K, GLY50L, ILE124K, ILE128K, ILE128L, ILE132K, ILE132L, ILE135K, ILE135L, ILE31L, ILE37L, LEU142K, LEU142L, LEU144K, LEU144L, LEU145L, LEU183K, LEU32L, LEU51K, LEU51L, LEU53L, LEU54K, LEU54L, LYS122K, LYS122L, LYS48L, MET196K, PHE141K, PHE141L, PHE186K, PHE26L, PHE43L, PRO143K, PRO143L, PRO202K, PRO39L, SER130K, SER130L, SER185K, SER195K, SER30K, SER30L, SER40L, THR136K, THR136L, THR138K, THR138L, THR140K, THR140L, THR42L, THR52K, THR52L, TRP100L, TYR199K, TYR33K, TYR33L, TYR38L, TYR49K, VAL131K, VAL131L, VAL139K, VAL139L, VAL181K, VAL197K, VAL46L