3GLH

crystal structure of the e. coli clamp loader bound to psi peptide

• Total interactions analyzed: 105
• Total true interactions: 33
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 77
  • Norm. En. per Res.: -3.6189
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-6.9668	-30.2027	-175.671	-212.8405	163	34	5	11451	0	44	39
A-C	0.0	0.0	-0.4027	-0.4027	6	0	0	36	0	1	1
A-E	-63.4469	-26.55	-188.657	-278.6539	77	22	4	8806	5	23	13
A-F	-120.3548	-104.0164	835.923	611.5518	48	152	1	4222	3	17	24
A-G	0.0	0.0	-24.0333	-24.0333	39	2	1	1370	0	1	3
A-L	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
A-M	-13.5808	-66.3486	43.6133	-36.3161	28	43	0	2064	2	9	8
B-C	-21.0912	-18.1255	-79.4055	-118.6222	159	48	6	10934	1	39	43
B-D	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
B-E	0.0	1.9064	-2.8179	-0.9115	4	0	0	123	0	1	2
B-M	0.0	0.0	-8.7182	-8.7182	20	0	0	747	0	7	4
C-D	-40.7291	10.0644	-312.028	-342.6927	240	144	9	24689	4	87	80
C-E	0.0	-10.5796	-13.627	-24.2066	17	2	1	781	0	4	3
D-E	-23.3174	-62.2084	-95.9417	-181.4675	190	88	4	16111	5	67	58
F-G	-11.173	-80.1366	-23.8934	-115.203	167	45	4	11871	3	46	41
F-H	0.0	0.0	-5.1776	-5.1776	8	0	0	236	0	2	2
F-J	-42.6122	-28.5759	-163.995	-235.1831	74	27	5	8189	5	20	12
F-M	0.0	0.0	-0.1341	-0.1341	4	0	0	29	0	1	0
F-N	-59.4761	-80.7626	220.411	80.1723	49	80	0	3288	4	21	18
G-H	-22.3205	-17.7826	66.6985	26.5954	172	75	8	12294	1	44	49
G-I	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
G-J	0.0	2.0767	-2.474	-0.3973	4	1	0	127	0	1	2
H-I	-37.7709	-6.2812	-202.26	-246.312	243	137	7	23730	4	84	80
H-J	0.0	-6.563	-15.0281	-21.5911	18	0	0	814	0	3	5
I-J	-38.484	-87.7002	49.2308	-76.9535	191	87	4	16347	8	66	60
K-L	-10.4963	-71.6813	-74.3958	-156.5734	174	45	6	11837	1	43	33
K-M	0.0	0.0	-0.1924	-0.1924	5	0	0	18	0	1	1
K-O	-61.6401	-37.1732	-155.912	-254.7253	79	30	2	8776	4	24	13
L-M	-11.5008	-0.4901	-100.961	-112.952	168	79	6	12757	1	47	49
L-O	0.0	0.0	-1.1213	-1.1213	4	0	0	81	0	1	1
M-N	-42.0666	-7.358	-19.3689	-68.7935	243	168	8	24825	4	85	79
M-O	0.0	1.2527	-11.3416	-10.0889	12	0	0	640	0	2	2
N-O	-11.7001	-80.0306	-138.208	-229.9387	193	101	5	16143	6	60	55

Interface residues

• A-B: ALA180A, ALA182A, ALA184A, ALA205A, ALA207B, ALA209A, ALA209B, ALA210A, ALA210B, ALA27B, ALA293B, ALA29B, ALA300B, ALA301B, ALA322A, ALA337A, ALA43A, ARG113A, ARG154A, ARG169B, ARG187A, ARG201A, ARG208B, ARG237A, ARG291B, ARG307A, ARG314B, ARG336B, ARG36B, ARG39A, ASN159A, ASN177A, ASN207A, ASN26A, ASN304B, ASN30B, ASP158B, ASP179B, ASP194A, ASP208A, ASP27A, ASP305B, ASP338A, ASP36A, CYS170B, CYS332A, GLN160B, GLN172B, GLN183A, GLN204A, GLN21B, GLN234A, GLN235A, GLN296B, GLN297A, GLN318A, GLN326B, GLN32A, GLN330B, GLN35A, GLU144B, GLU145B, GLU186A, GLU211B, GLU22B, GLU239A, GLU242A, GLU323A, GLU325A, GLU33A, GLY195A, GLY20B, GLY212B, GLY240A, GLY287B, GLY303B, GLY31B, GLY326A, GLY45B, HIS174B, HIS231A, HIS23B, HIS290B, HIS333A, HIS38B, HIS50A, ILE166B, ILE245A, ILE325B, ILE37B, LEU140B, LEU158A, LEU160A, LEU162B, LEU167B, LEU171B, LEU175B, LEU178B, LEU179A, LEU185A, LEU188A, LEU190A, LEU191A, LEU230A, LEU238A, LEU25B, LEU28B, LEU297B, LEU29A, LEU302B, LEU304A, LEU30A, LEU31A, LEU327A, LEU327B, LEU329A, LEU32B, LEU330A, LEU333B, LEU336A, LEU34B, LEU42B, LYS176B, LYS225A, LYS227A, LYS334A, MET294B, MET306B, PHE173B, PHE212A, PRO159B, PRO163B, PRO193A, PRO28A, PRO299B, PRO322B, PRO335A, SER168B, SER189A, SER213B, SER226A, SER241A, SER298B, SER33B, SER44B, THR157B, THR165B, THR26B, THR311A, THR323B, THR46B, TRP192A, TYR174A, TYR329B, TYR41B, VAL164B, VAL180B, VAL202A, VAL206A, VAL24B, VAL283B, VAL295B, VAL49B
• A-C: ASP315A, GLN160C, GLN318A, GLY317A, SER319A, TYR316A
• A-E: ALA301A, ALA337A, ARG248A, ARG252A, ARG262A, ARG299A, ARG307A, ARG308E, ARG318E, ASN237E, ASN259A, ASN307E, ASP228E, ASP314E, GLN251A, GLN263A, GLN295A, GLN299E, GLN300A, GLN303A, GLN314A, GLN324E, GLU298E, GLU309A, GLU309E, GLU320E, GLY227E, GLY305E, HIS266A, HIS276A, HIS295E, HIS321E, ILE296E, ILE306E, ILE312E, ILE319E, LEU232E, LEU233E, LEU247A, LEU250A, LEU254A, LEU255A, LEU256A, LEU257A, LEU260A, LEU298A, LEU300E, LEU304A, LEU305A, LEU310A, LEU310E, LEU311E, LEU312A, LEU315E, LEU316E, LEU317E, LEU327A, LYS313A, SER231E, SER302E, THR249A, THR296A, THR304E, THR306A, THR308A, THR311A, THR313E, TRP229E, TYR222E, TYR230E, TYR316A, TYR322E, VAL244A, VAL258A, VAL302A, VAL303E, VAL327E
• A-F: ALA165F, ALA19A, ALA209F, ALA210F, ALA229F, ALA70A, ALA75A, ARG133A, ARG228F, ARG77A, ASN207F, ASP106A, ASP107A, ASP208F, CYS173F, CYS332F, GLN204F, GLN69A, GLN78A, GLU203F, GLU288F, GLU48A, GLU49A, GLY102A, GLY224F, HIS105A, HIS231F, HIS333F, LEU103A, LEU104A, LEU108A, LEU109A, LEU130A, LEU199F, LEU73A, LYS225F, LYS227F, MET223F, PHE212F, PHE47A, PHE74A, PRO200F, SER226F, SER72A, SER76A, THR101A, VAL169F, VAL206F
• A-G: ALA125A, ALA129A, ALA131A, ALA19A, ALA300G, ALA301G, ALA307G, ALA317G, ARG133A, ARG18A, ARG314G, ARG318G, ASN123A, ASN132A, ASP106A, ASP179G, GLN296G, GLU22G, GLU310G, GLU315G, GLY102A, HIS105A, HIS23G, LEU104A, LEU130A, LEU297G, LEU302G, LEU311G, LEU73A, LEU98A, MET1A, MET294G, PRO299G, SER134A, SER298G, THR101A, THR128A, THR99A, VAL295G
• A-L: LYS156A, PRO368L
• A-M: ALA155A, ARG201A, ARG312M, ARG314M, ARG318M, ASN159A, ASP194A, GLU161A, GLU258M, GLU310M, GLU315M, GLY195A, ILE320M, LEU158A, LEU160A, LEU162A, LEU190A, LEU191A, LEU197A, LEU311M, LEU316M, LYS156A, LYS196A, PRO193A, PRO299M, SER189A, THR319M, TRP192A
• B-C: ALA138C, ALA224B, ALA226B, ALA236B, ALA239B, ALA259B, ALA272B, ALA273B, ALA27C, ALA280C, ALA293C, ALA29C, ALA301C, ALA342B, ALA356B, ALA358B, ALA95B, ALA96B, ARG105C, ARG133C, ARG169C, ARG208C, ARG274B, ARG291C, ARG318C, ARG336C, ARG345B, ARG346B, ARG355B, ARG36C, ARG47B, ARG98B, ASN137C, ASN260B, ASN30C, ASP179C, ASP222B, ASP229B, ASP344B, ASP94B, GLN112C, GLN172C, GLN182C, GLN204C, GLN223B, GLN235B, GLN296C, GLN326C, GLN330C, GLN4B, GLU127B, GLU144C, GLU145C, GLU181C, GLU211C, GLU22C, GLU262B, GLU277B, GLU279C, GLU284C, GLU338B, GLU338C, GLU350B, GLU367B, GLY228B, GLY230B, GLY261B, GLY275B, GLY287C, GLY31C, GLY335B, GLY348B, HIS134C, HIS174C, HIS23C, HIS290C, HIS38C, ILE225B, ILE268B, ILE276B, ILE292C, ILE325C, ILE334B, ILE334C, LEU139C, LEU140C, LEU143C, LEU171C, LEU178C, LEU282C, LEU286C, LEU288C, LEU289C, LEU28C, LEU297C, LEU332C, LEU333C, LEU339B, LEU339C, LEU34C, LEU353B, LEU354B, LEU357B, LEU365B, LYS100B, LYS141C, LYS176C, LYS337B, LYS337C, MET130B, MET240B, MET265B, MET285C, MET294C, MET347B, MET351B, MET363B, PHE136C, PHE173C, PHE359B, PRO146C, PRO163C, PRO321C, PRO322C, PRO340B, PRO340C, PRO343B, PRO364B, PRO366B, PRO368B, SER135C, SER168C, SER219B, SER227B, SER238B, SER298C, SER97B, THR142C, THR157B, THR165C, THR243B, THR26C, THR319C, THR323C, THR352B, THR99B, TYR329C, TYR341B, TYR341C, TYR3B, VAL101B, VAL164C, VAL180C, VAL24C, VAL264B, VAL283C, VAL295C, VAL349B, VAL5B
• B-D: LYS337D, TYR341B
• B-E: HIS333E, LEU334E, LYS337B, TYR341B
• B-M: ALA307M, ALA308M, ARG263M, ARG312M, ARG36B, ASN30B, ASP247M, GLN235M, GLU254M, GLU310M, GLU315M, GLY35B, GLY67B, ILE309M, ILE68B, LEU250M, LEU311M, LEU34B, SER33B, THR66B
• C-D: ALA138D, ALA224C, ALA226C, ALA236C, ALA239C, ALA259C, ALA272C, ALA273C, ALA27D, ALA293D, ALA29D, ALA301D, ALA317D, ALA342C, ALA356C, ALA358C, ALA40D, ALA7C, ALA95C, ALA95D, ALA96C, ALA96D, ARG105C, ARG105D, ARG11C, ARG133D, ARG169D, ARG208D, ARG215C, ARG263C, ARG274C, ARG291D, ARG318D, ARG336D, ARG345C, ARG346C, ARG355C, ARG36D, ARG47C, ARG56C, ARG80C, ARG86C, ARG8C, ARG98C, ARG98D, ASN137D, ASN260C, ASN269C, ASN30D, ASP103C, ASP106C, ASP126C, ASP179D, ASP216C, ASP222C, ASP229C, ASP324D, ASP344C, ASP94C, CYS170D, GLN13C, GLN160D, GLN172D, GLN182D, GLN204D, GLN21D, GLN223C, GLN231C, GLN235C, GLN296D, GLN326D, GLN330D, GLN4C, GLN84C, GLU102C, GLU127C, GLU144D, GLU145D, GLU148D, GLU181D, GLU22D, GLU262C, GLU277C, GLU279D, GLU284D, GLU338C, GLU338D, GLU350C, GLU367C, GLU81C, GLU83C, GLU92C, GLY20D, GLY228C, GLY230C, GLY261C, GLY275C, GLY287D, GLY31D, GLY335C, GLY335D, GLY348C, GLY48C, GLY50C, GLY85C, HIS129D, HIS134D, HIS174D, HIS23D, HIS290D, HIS38D, HIS39D, ILE125C, ILE166D, ILE225C, ILE268C, ILE276C, ILE292D, ILE320D, ILE325D, ILE334C, ILE334D, ILE37D, ILE82C, ILE91C, ILE93C, LEU107C, LEU108D, LEU124C, LEU131C, LEU131D, LEU139D, LEU140D, LEU143D, LEU162D, LEU167D, LEU171D, LEU178D, LEU218C, LEU220C, LEU241C, LEU25D, LEU282D, LEU286D, LEU288D, LEU289D, LEU28D, LEU297D, LEU316D, LEU327D, LEU332D, LEU333D, LEU339C, LEU339D, LEU34D, LEU353C, LEU354C, LEU357C, LEU365C, LEU42D, LEU6C, LEU90C, LYS100C, LYS141D, LYS151D, LYS161D, LYS176D, LYS337C, LYS337D, LYS51C, LYS9C, MET130C, MET130D, MET240C, MET265C, MET285D, MET294D, MET347C, MET351C, PHE136D, PHE173D, PHE359C, PHE43D, PHE87C, PRO12C, PRO146D, PRO159D, PRO163D, PRO321D, PRO322D, PRO340C, PRO340D, PRO343C, PRO364C, PRO366C, PRO368C, SER132D, SER135C, SER135D, SER168D, SER219C, SER227C, SER238C, SER298D, SER33D, SER44D, SER53C, SER97C, SER97D, THR104C, THR142D, THR165D, THR221C, THR243C, THR26D, THR319D, THR323D, THR331C, THR331D, THR352C, THR52C, THR99C, TRP10C, TRP278C, TYR329D, TYR341C, TYR341D, TYR3C, TYR41D, VAL101C, VAL164D, VAL180D, VAL237C, VAL24D, VAL264C, VAL283D, VAL295D, VAL349C, VAL49C, VAL5C
• C-E: ALA123E, ARG336C, ARG98C, ASP91E, GLU338C, GLU82E, GLY89E, HIS333E, ILE334C, LEU334E, LEU339C, LYS337C, LYS85E, PRO340C, THR121E, TYR341C, VAL90E
• D-E: ALA118E, ALA123E, ALA125E, ALA127E, ALA153E, ALA195E, ALA209D, ALA210D, ALA217D, ALA224D, ALA226D, ALA239D, ALA249E, ALA255E, ALA259D, ALA262E, ALA263E, ALA266D, ALA271D, ALA272D, ALA273D, ALA278E, ALA280D, ALA288E, ALA342D, ALA356D, ALA358D, ALA92E, ALA96D, ARG146E, ARG150E, ARG156E, ARG158E, ARG160E, ARG192E, ARG208D, ARG215D, ARG258E, ARG263D, ARG274D, ARG285E, ARG297E, ARG345D, ARG346D, ARG355D, ARG47D, ARG94E, ARG98D, ASN126E, ASN260D, ASN267E, ASN269D, ASN279E, ASP122E, ASP216D, ASP222D, ASP254E, ASP292E, ASP344D, ASP91E, ASP94D, CYS159E, CYS294E, GLN223D, GLN264E, GLN287E, GLN299E, GLN30E, GLN330D, GLU133E, GLU147E, GLU149E, GLU211D, GLU262D, GLU276E, GLU277D, GLU279D, GLU298E, GLU338D, GLU350D, GLU367D, GLU95E, GLU98E, GLY261D, GLY261E, GLY275D, GLY291E, GLY335D, GLY348D, GLY48D, HIS246E, HIS24E, HIS259E, HIS25E, HIS260E, HIS280E, HIS295E, HIS333E, HIS360D, ILE268D, ILE276D, ILE289E, ILE296E, ILE334D, LEU129E, LEU132E, LEU151E, LEU152E, LEU155E, LEU161E, LEU193E, LEU205D, LEU206D, LEU218D, LEU220D, LEU241D, LEU245E, LEU248E, LEU251E, LEU252E, LEU256E, LEU281D, LEU281E, LEU286E, LEU28E, LEU290E, LEU329E, LEU32E, LEU333D, LEU334E, LEU339D, LEU353D, LEU354D, LEU357D, LEU365D, LYS130E, LYS257E, LYS337D, MET130D, MET240D, MET253E, MET265D, MET301E, MET347D, MET351D, MET363D, PHE359D, PRO148E, PRO166E, PRO242E, PRO283E, PRO330E, PRO332E, PRO340D, PRO343D, PRO364D, PRO366D, PRO368D, SER157E, SER194E, SER213D, SER219D, SER227D, SER238D, SER282E, SER284E, SER302E, SER97D, THR154E, THR157D, THR221D, THR243D, THR250E, THR266E, THR331D, THR352D, THR46D, THR99D, TRP247E, TRP278D, TYR163E, TYR341D, VAL237D, VAL264D, VAL265E, VAL293E, VAL331E, VAL349D, VAL5D, VAL90E
• F-G: ALA182F, ALA184F, ALA205F, ALA207G, ALA209F, ALA209G, ALA210F, ALA210G, ALA27G, ALA293G, ALA29G, ALA300G, ALA301G, ALA322F, ALA337F, ALA43F, ALA44F, ARG113F, ARG169G, ARG187F, ARG208G, ARG237F, ARG291G, ARG307F, ARG314G, ARG336G, ARG36G, ARG39F, ARG47G, ASN159F, ASN177F, ASN304G, ASN30G, ASP158G, ASP179G, ASP194F, ASP208F, ASP27F, ASP305G, ASP315F, ASP338F, ASP36F, CYS170G, CYS332F, GLN160G, GLN172G, GLN182G, GLN183F, GLN204F, GLN21G, GLN234F, GLN235F, GLN296G, GLN297F, GLN300F, GLN318F, GLN326G, GLN32F, GLN330G, GLN35F, GLN40F, GLU144G, GLU145G, GLU186F, GLU211G, GLU22G, GLU239F, GLU242F, GLU325F, GLU33F, GLU48F, GLU49F, GLY195F, GLY212G, GLY240F, GLY287G, GLY303G, GLY31G, GLY326F, GLY35G, GLY45G, HIS174G, HIS231F, HIS23G, HIS290G, HIS333F, HIS38G, HIS50F, ILE166G, ILE183G, ILE245F, ILE325G, ILE37G, LEU140G, LEU158F, LEU160F, LEU167G, LEU171G, LEU175G, LEU178G, LEU179F, LEU185F, LEU188F, LEU190F, LEU191F, LEU230F, LEU233F, LEU236F, LEU238F, LEU28G, LEU297G, LEU29F, LEU302G, LEU304F, LEU30F, LEU31F, LEU327F, LEU327G, LEU329F, LEU32G, LEU330F, LEU333G, LEU336F, LEU34G, LEU42G, LYS141G, LYS161G, LYS176G, LYS225F, LYS227F, LYS334F, MET294G, MET306G, PHE173G, PHE212F, PRO159G, PRO163G, PRO193F, PRO28F, PRO299G, PRO322G, PRO335F, SER168G, SER189F, SER213G, SER226F, SER241F, SER298G, SER319F, SER33G, SER44G, THR157G, THR165G, THR26G, THR311F, THR323G, THR46G, THR52F, TRP192F, TYR329G, TYR41G, VAL164G, VAL180G, VAL24G, VAL283G, VAL295G, VAL49G
• F-H: ASP158H, ASP315F, GLN160H, GLN318F, GLY317F, LYS161H, SER319F, TYR316F
• F-J: ALA301F, ALA337F, ARG248F, ARG252F, ARG262F, ARG299F, ARG307F, ARG308J, ARG318J, ASN237J, ASN259F, ASN307J, ASP228J, ASP314J, GLN251F, GLN263F, GLN295F, GLN299J, GLN300F, GLN303F, GLN314F, GLN324J, GLU309F, GLU309J, GLU320J, GLY227J, GLY305J, HIS266F, HIS321J, ILE296J, ILE306J, ILE312J, ILE319J, LEU232J, LEU233J, LEU247F, LEU250F, LEU254F, LEU255F, LEU256F, LEU257F, LEU260F, LEU298F, LEU300J, LEU304F, LEU305F, LEU310F, LEU310J, LEU311J, LEU312F, LEU315J, LEU316J, LEU317J, LEU327F, LYS261F, LYS313F, SER231J, SER302J, THR249F, THR296F, THR304J, THR306F, THR308F, THR311F, THR313J, TRP229J, TYR222J, TYR230J, TYR316F, VAL244F, VAL258F, VAL302F, VAL303J, VAL327J
• F-M: ARG270F, ASN291F, GLU367M, PRO368M
• F-N: ALA145F, ALA255N, ALA259N, ALA265F, ALA271F, ALA307N, ALA317N, ARG263N, ARG270F, ARG283F, ARG312N, ARG314N, ARG318N, ARG362N, ASN260N, ASN281F, ASN291F, ASP274F, GLN144F, GLN280F, GLN296N, GLU254N, GLU258N, GLU288F, GLU310N, GLU315N, GLY284F, GLY287F, HIS360N, ILE292N, ILE320N, ILE325N, LEU250N, LEU269F, LEU272F, LEU311N, LEU316N, LYS275F, MET285F, MET313N, PHE273F, PRO268F, PRO321N, SER264F, THR267F, THR319N, TRP279F, VAL253N, VAL257N
• G-H: ALA224G, ALA226G, ALA236G, ALA239G, ALA259G, ALA271G, ALA272G, ALA273G, ALA27H, ALA280H, ALA293H, ALA29H, ALA301H, ALA342G, ALA356G, ALA358G, ALA7G, ALA96G, ARG105H, ARG133H, ARG169H, ARG208H, ARG274G, ARG291H, ARG318H, ARG336H, ARG345G, ARG346G, ARG355G, ARG36H, ARG47G, ARG98G, ASN137H, ASN260G, ASN30H, ASP126G, ASP179H, ASP216G, ASP222G, ASP229G, ASP344G, ASP94G, CYS170H, GLN112H, GLN172H, GLN182H, GLN223G, GLN231G, GLN235G, GLN296H, GLN326H, GLN330H, GLN4G, GLU144H, GLU145H, GLU181H, GLU211G, GLU211H, GLU22H, GLU262G, GLU277G, GLU279H, GLU284H, GLU338G, GLU338H, GLU350G, GLU367G, GLY228G, GLY230G, GLY261G, GLY275G, GLY287H, GLY31H, GLY335G, GLY348G, GLY35H, GLY48G, HIS134H, HIS174H, HIS23H, HIS290H, HIS38H, HIS39H, ILE166H, ILE196G, ILE225G, ILE268G, ILE276G, ILE292H, ILE320H, ILE325H, ILE334G, ILE334H, ILE37H, LEU140H, LEU167H, LEU171H, LEU178H, LEU220G, LEU241G, LEU25H, LEU282H, LEU286H, LEU288H, LEU289H, LEU28H, LEU297H, LEU32H, LEU332H, LEU333H, LEU339G, LEU339H, LEU34H, LEU353G, LEU354G, LEU357G, LEU365G, LEU6G, LYS100G, LYS141H, LYS176H, LYS337G, LYS337H, LYS9G, MET130G, MET240G, MET265G, MET285H, MET294H, MET347G, MET351G, MET363G, PHE173H, PHE359G, PRO321H, PRO322H, PRO340G, PRO340H, PRO343G, PRO364G, PRO366G, PRO368G, SER168H, SER219G, SER227G, SER238G, SER298H, SER33H, SER97G, THR157G, THR165H, THR221G, THR243G, THR26H, THR319H, THR323H, THR352G, THR46G, THR99G, TYR329H, TYR341G, TYR341H, TYR3G, TYR41H, VAL164H, VAL180H, VAL24H, VAL264G, VAL283H, VAL295H, VAL349G, VAL5G
• G-I: LYS337I, TYR341G
• G-J: HIS333J, LEU334J, LYS337G, TYR341G
• H-I: ALA138I, ALA224H, ALA226H, ALA236H, ALA239H, ALA259H, ALA266H, ALA272H, ALA273H, ALA27I, ALA293I, ALA301I, ALA317I, ALA342H, ALA356H, ALA358H, ALA40I, ALA7H, ALA95H, ALA95I, ALA96H, ALA96I, ARG105H, ARG105I, ARG11H, ARG133I, ARG169I, ARG208I, ARG215H, ARG263H, ARG274H, ARG291I, ARG318I, ARG336I, ARG345H, ARG346H, ARG355H, ARG36I, ARG47H, ARG56H, ARG80H, ARG86H, ARG8H, ARG98H, ARG98I, ASN137I, ASN260H, ASN269H, ASN30I, ASP103H, ASP106H, ASP126H, ASP158I, ASP179I, ASP216H, ASP222H, ASP229H, ASP324I, ASP344H, ASP94H, CYS170I, GLN13H, GLN160I, GLN172I, GLN182I, GLN204I, GLN21I, GLN223H, GLN231H, GLN235H, GLN296I, GLN326I, GLN330I, GLN4H, GLN84H, GLU102H, GLU127H, GLU144I, GLU145I, GLU148I, GLU181I, GLU22I, GLU262H, GLU277H, GLU279I, GLU284I, GLU338H, GLU338I, GLU350H, GLU367H, GLU81H, GLU83H, GLU92H, GLY20I, GLY228H, GLY230H, GLY261H, GLY275H, GLY287I, GLY31I, GLY335H, GLY335I, GLY348H, GLY48H, GLY50H, GLY85H, HIS129I, HIS134I, HIS174I, HIS23I, HIS290I, HIS360H, HIS38I, HIS39I, ILE125H, ILE166I, ILE225H, ILE268H, ILE276H, ILE292I, ILE320I, ILE325I, ILE334H, ILE334I, ILE37I, ILE54H, ILE82H, ILE91H, ILE93H, LEU107H, LEU108H, LEU108I, LEU124H, LEU131H, LEU131I, LEU139I, LEU140I, LEU143I, LEU162I, LEU167I, LEU171I, LEU178I, LEU218H, LEU220H, LEU241H, LEU25I, LEU282I, LEU286I, LEU288I, LEU289I, LEU28I, LEU297I, LEU316I, LEU327I, LEU332I, LEU333I, LEU339H, LEU339I, LEU34I, LEU353H, LEU354H, LEU357H, LEU365H, LEU42I, LEU6H, LEU90H, LYS100H, LYS141I, LYS151I, LYS161I, LYS176I, LYS337H, LYS337I, LYS51H, LYS9H, MET130H, MET130I, MET240H, MET265H, MET285I, MET294I, MET347H, MET351H, PHE136I, PHE173I, PHE359H, PHE87H, PRO12H, PRO146I, PRO159I, PRO163I, PRO321I, PRO322I, PRO340H, PRO340I, PRO343H, PRO364H, PRO366H, PRO368H, SER132I, SER135I, SER168I, SER219H, SER227H, SER238H, SER298I, SER33I, SER44I, SER53H, SER97H, SER97I, THR104H, THR142I, THR157H, THR165I, THR221H, THR243H, THR26I, THR319I, THR323I, THR331H, THR331I, THR352H, THR52H, THR99H, TRP10H, TRP278H, TYR123H, TYR329I, TYR341H, TYR341I, TYR3H, TYR41I, VAL101H, VAL164I, VAL180I, VAL24I, VAL264H, VAL283I, VAL295I, VAL349H, VAL49H, VAL5H
• H-J: ALA123J, ARG336H, ARG98H, ASP91J, GLU338H, GLU82J, GLY335H, GLY89J, HIS333J, ILE334H, LEU334J, LEU339H, LYS337H, LYS85J, PRO340H, THR121J, TYR341H, VAL90J
• I-J: ALA118J, ALA123J, ALA125J, ALA127J, ALA153J, ALA195J, ALA209I, ALA210I, ALA217I, ALA224I, ALA226I, ALA239I, ALA249J, ALA255J, ALA259I, ALA262J, ALA263J, ALA266I, ALA272I, ALA273I, ALA278J, ALA280I, ALA288J, ALA342I, ALA356I, ALA358I, ALA7I, ALA92J, ALA96I, ARG146J, ARG150J, ARG156J, ARG158J, ARG160J, ARG192J, ARG208I, ARG215I, ARG258J, ARG263I, ARG274I, ARG285J, ARG297J, ARG345I, ARG346I, ARG355I, ARG47I, ARG94J, ARG98I, ASN126J, ASN260I, ASN267J, ASN269I, ASN279J, ASP122J, ASP216I, ASP222I, ASP254J, ASP292J, ASP344I, ASP91J, ASP94I, CYS159J, CYS294J, GLN223I, GLN264J, GLN287J, GLN299J, GLN30J, GLN330I, GLU133J, GLU147J, GLU149J, GLU211I, GLU262I, GLU276J, GLU277I, GLU279I, GLU298J, GLU338I, GLU350I, GLU367I, GLU82J, GLU95J, GLU98J, GLY261I, GLY261J, GLY275I, GLY291J, GLY335I, GLY348I, GLY48I, GLY89J, HIS246J, HIS24J, HIS259J, HIS25J, HIS260J, HIS280J, HIS295J, HIS333J, HIS360I, ILE268I, ILE276I, ILE289J, ILE296J, ILE334I, LEU129J, LEU132J, LEU151J, LEU152J, LEU155J, LEU161J, LEU193J, LEU205I, LEU206I, LEU218I, LEU220I, LEU241I, LEU245J, LEU248J, LEU251J, LEU252J, LEU256J, LEU281I, LEU281J, LEU286J, LEU28J, LEU290J, LEU329J, LEU32J, LEU333I, LEU334J, LEU339I, LEU353I, LEU354I, LEU357I, LEU365I, LYS130J, LYS257J, LYS337I, MET130I, MET240I, MET253J, MET265I, MET301J, MET347I, MET351I, MET363I, PHE359I, PRO148J, PRO166J, PRO242J, PRO283J, PRO330J, PRO332J, PRO340I, PRO343I, PRO364I, PRO366I, PRO368I, SER157J, SER194J, SER213I, SER219I, SER227I, SER238I, SER282J, SER284J, SER97I, THR154J, THR157I, THR221I, THR243I, THR250J, THR266J, THR331I, THR352I, THR46I, THR99I, TRP247J, TRP278I, TYR163J, TYR341I, VAL237I, VAL264I, VAL265J, VAL293J, VAL331J, VAL349I, VAL5I, VAL90J
• K-L: ALA180K, ALA182K, ALA184K, ALA205K, ALA207L, ALA209K, ALA210K, ALA210L, ALA27L, ALA293L, ALA29L, ALA300L, ALA301L, ALA322K, ALA337K, ALA43K, ARG113K, ARG133L, ARG154K, ARG169L, ARG187K, ARG201K, ARG208L, ARG228K, ARG237K, ARG291L, ARG307K, ARG336L, ARG36L, ARG39K, ASN137L, ASN159K, ASN177K, ASN207K, ASN26K, ASN304L, ASN30L, ASP158L, ASP179L, ASP194K, ASP208K, ASP27K, ASP305L, ASP315K, ASP338K, ASP36K, CYS170L, CYS332K, GLN160L, GLN172L, GLN182L, GLN183K, GLN204K, GLN21L, GLN234K, GLN235K, GLN296L, GLN318K, GLN326L, GLN32K, GLN330L, GLN35K, GLN40K, GLU144L, GLU145L, GLU186K, GLU211L, GLU22L, GLU239K, GLU242K, GLU323K, GLU325K, GLU33K, GLU48K, GLU49K, GLY195K, GLY212L, GLY240K, GLY287L, GLY303L, GLY31L, GLY326K, GLY45L, HIS174L, HIS231K, HIS23L, HIS290L, HIS333K, HIS38L, HIS50K, HIS51K, ILE166L, ILE183L, ILE37L, LEU140L, LEU158K, LEU160K, LEU162L, LEU167L, LEU171L, LEU175L, LEU178L, LEU179K, LEU185K, LEU188K, LEU190K, LEU191K, LEU230K, LEU238K, LEU25L, LEU28L, LEU297L, LEU29K, LEU302L, LEU304K, LEU30K, LEU31K, LEU324K, LEU327K, LEU327L, LEU329K, LEU32L, LEU330K, LEU331K, LEU333L, LEU336K, LEU34L, LEU42L, LEU81K, LEU83K, LYS141L, LYS176L, LYS225K, LYS227K, LYS334K, MET294L, PHE173L, PHE212K, PRO159L, PRO163L, PRO193K, PRO28K, PRO299L, PRO322L, PRO335K, SER168L, SER189K, SER213L, SER226K, SER241K, SER298L, SER319K, SER328K, SER33L, SER54K, THR157L, THR165L, THR26L, THR311K, THR323L, THR46L, THR52K, TRP192K, TRP321K, TYR174K, TYR329L, TYR41L, VAL164L, VAL180L, VAL206K, VAL24L, VAL283L, VAL295L, VAL49L
• K-M: GLN160M, GLN318K, GLY317K, SER319K, TYR316K
• K-O: ALA301K, ALA337K, ARG248K, ARG252K, ARG262K, ARG299K, ARG307K, ARG308O, ARG318O, ASN237O, ASN259K, ASN307O, ASP228O, ASP314O, GLN251K, GLN263K, GLN295K, GLN297K, GLN299O, GLN300K, GLN303K, GLN314K, GLN324O, GLU298O, GLU309K, GLU309O, GLU320O, GLY227O, GLY305O, HIS266K, HIS295O, HIS321O, ILE296O, ILE306O, ILE312O, ILE319O, LEU232O, LEU233O, LEU247K, LEU250K, LEU254K, LEU255K, LEU256K, LEU257K, LEU260K, LEU298K, LEU300O, LEU304K, LEU305K, LEU310K, LEU310O, LEU311O, LEU312K, LEU315O, LEU316O, LEU317O, LEU327K, LYS261K, LYS313K, SER226O, SER231O, SER302O, THR249K, THR296K, THR304O, THR306K, THR308K, THR313O, TRP229O, TYR222O, TYR230O, TYR316K, TYR322O, VAL244K, VAL258K, VAL302K, VAL303O, VAL327O, VAL328O
• L-M: ALA138M, ALA224L, ALA226L, ALA236L, ALA239L, ALA259L, ALA271L, ALA272L, ALA273L, ALA27M, ALA280M, ALA293M, ALA29M, ALA300M, ALA301M, ALA342L, ALA356L, ALA358L, ALA96L, ARG105M, ARG169M, ARG208M, ARG274L, ARG291M, ARG318M, ARG336M, ARG345L, ARG346L, ARG355L, ARG36M, ARG47L, ARG98L, ASN137M, ASN260L, ASN269L, ASN30M, ASP179M, ASP216L, ASP222L, ASP229L, ASP246L, ASP247L, ASP344L, ASP94L, CYS170M, GLN112M, GLN172M, GLN182M, GLN204M, GLN21M, GLN223L, GLN235L, GLN296M, GLN326M, GLN330M, GLN4L, GLU144M, GLU145M, GLU181M, GLU211L, GLU211M, GLU22M, GLU262L, GLU277L, GLU279M, GLU284M, GLU338L, GLU338M, GLU350L, GLU367L, GLY228L, GLY230L, GLY261L, GLY275L, GLY287M, GLY31M, GLY335L, GLY348L, GLY45M, HIS174M, HIS23M, HIS290M, HIS38M, ILE225L, ILE268L, ILE276L, ILE292M, ILE325M, ILE334L, ILE334M, LEU140M, LEU167M, LEU171M, LEU175M, LEU178M, LEU220L, LEU241L, LEU244L, LEU25M, LEU282M, LEU286M, LEU288M, LEU289M, LEU28M, LEU297M, LEU332M, LEU333M, LEU339L, LEU339M, LEU34M, LEU353L, LEU354L, LEU357L, LEU365L, LYS100L, LYS141M, LYS176M, LYS337L, LYS337M, MET130L, MET240L, MET265L, MET285M, MET294M, MET306M, MET347L, MET351L, MET363L, PHE173M, PHE359L, PRO321M, PRO322M, PRO340L, PRO340M, PRO343L, PRO364L, PRO366L, PRO368L, SER168M, SER219L, SER227L, SER233L, SER238L, SER298M, SER97L, THR165M, THR243L, THR26M, THR323M, THR352L, THR46L, THR46M, THR99L, TRP278L, TYR329M, TYR341L, TYR341M, TYR3L, TYR41M, VAL164M, VAL180M, VAL237L, VAL24M, VAL264L, VAL283M, VAL295M, VAL349L, VAL5L
• L-O: HIS333O, LEU334O, LYS337L, TYR341L
• M-N: ALA138N, ALA224M, ALA226M, ALA236M, ALA239M, ALA259M, ALA266M, ALA272M, ALA273M, ALA27N, ALA280M, ALA293N, ALA29N, ALA301N, ALA317N, ALA342M, ALA356M, ALA358M, ALA40N, ALA7M, ALA95M, ALA95N, ALA96M, ARG105M, ARG105N, ARG11M, ARG133N, ARG169N, ARG208N, ARG215M, ARG263M, ARG274M, ARG291N, ARG318N, ARG336N, ARG345M, ARG346M, ARG355M, ARG36N, ARG47M, ARG56M, ARG80M, ARG86M, ARG8M, ARG98M, ARG98N, ASN137N, ASN260M, ASN269M, ASN30N, ASP103M, ASP106M, ASP126M, ASP179N, ASP216M, ASP222M, ASP229M, ASP324N, ASP344M, ASP94M, CYS170N, GLN13M, GLN160N, GLN172N, GLN182N, GLN21N, GLN223M, GLN231M, GLN235M, GLN296N, GLN326N, GLN330N, GLN4M, GLN84M, GLU102M, GLU127M, GLU144N, GLU145N, GLU148N, GLU181N, GLU22N, GLU262M, GLU277M, GLU279N, GLU284N, GLU315N, GLU338M, GLU338N, GLU350M, GLU367M, GLU81M, GLU83M, GLU92M, GLY20N, GLY228M, GLY230M, GLY261M, GLY275M, GLY287N, GLY31N, GLY335M, GLY335N, GLY348M, GLY48M, GLY50M, GLY85M, HIS129N, HIS134N, HIS174N, HIS23N, HIS290N, HIS360M, HIS38N, HIS39N, ILE125M, ILE166N, ILE196M, ILE225M, ILE268M, ILE276M, ILE292N, ILE320N, ILE325N, ILE334M, ILE334N, ILE37N, ILE82M, ILE91M, ILE93M, LEU107M, LEU108N, LEU124M, LEU131M, LEU131N, LEU139N, LEU140N, LEU143N, LEU162N, LEU167N, LEU171N, LEU178N, LEU218M, LEU220M, LEU241M, LEU25N, LEU282N, LEU286N, LEU288N, LEU289N, LEU28N, LEU297N, LEU316N, LEU327N, LEU332N, LEU333N, LEU339M, LEU339N, LEU34N, LEU353M, LEU354M, LEU357M, LEU365M, LEU42N, LEU6M, LEU90M, LYS100M, LYS141N, LYS151N, LYS161N, LYS176N, LYS337M, LYS337N, LYS51M, LYS9M, MET130N, MET240M, MET265M, MET285N, MET294N, MET347M, MET351M, PHE136N, PHE173N, PHE359M, PHE87M, PRO12M, PRO146N, PRO159N, PRO163N, PRO299N, PRO321N, PRO322N, PRO340M, PRO340N, PRO343M, PRO364M, PRO366M, PRO368M, SER132N, SER135N, SER168N, SER213M, SER219M, SER227M, SER238M, SER298N, SER33N, SER44N, SER53M, SER97M, SER97N, THR104M, THR142N, THR165N, THR221M, THR243M, THR26N, THR319N, THR323N, THR331M, THR331N, THR352M, THR52M, THR99M, TRP10M, TRP278M, TYR328N, TYR329N, TYR341M, TYR341N, TYR3M, TYR41N, VAL101M, VAL164N, VAL180N, VAL237M, VAL24N, VAL264M, VAL283N, VAL295N, VAL349M, VAL49M, VAL5M
• M-O: ARG336M, ARG98M, GLU338M, HIS333O, ILE334M, LEU334O, LEU339M, LYS337M, LYS85O, PRO340M, THR121O, TYR341M
• N-O: ALA118O, ALA123O, ALA125O, ALA153O, ALA195O, ALA209N, ALA210N, ALA217N, ALA224N, ALA226N, ALA236N, ALA239N, ALA243O, ALA249O, ALA255O, ALA259N, ALA262O, ALA263O, ALA266N, ALA271N, ALA272N, ALA273N, ALA275O, ALA278O, ALA280N, ALA288O, ALA342N, ALA356N, ALA358N, ALA7N, ALA96N, ARG146O, ARG150O, ARG156O, ARG158O, ARG160O, ARG192O, ARG208N, ARG215N, ARG258O, ARG263N, ARG274N, ARG285O, ARG297O, ARG345N, ARG346N, ARG355N, ARG47N, ARG94O, ARG98N, ASN126O, ASN260N, ASN267O, ASN269N, ASN279O, ASP122O, ASP216N, ASP222N, ASP254O, ASP292O, ASP344N, ASP91O, CYS159O, CYS294O, GLN223N, GLN264O, GLN287O, GLN299O, GLN30O, GLN330N, GLU133O, GLU147O, GLU149O, GLU211N, GLU262N, GLU276O, GLU277N, GLU279N, GLU298O, GLU338N, GLU350N, GLU367N, GLU82O, GLU95O, GLU98O, GLY196O, GLY261N, GLY261O, GLY275N, GLY291O, GLY335N, GLY348N, GLY48N, HIS246O, HIS24O, HIS259O, HIS25O, HIS260O, HIS280O, HIS295O, HIS333O, HIS360N, ILE225N, ILE268N, ILE276N, ILE289O, ILE296O, ILE334N, LEU129O, LEU132O, LEU151O, LEU152O, LEU155O, LEU161O, LEU193O, LEU205N, LEU206N, LEU218N, LEU220N, LEU241N, LEU245O, LEU251O, LEU252O, LEU256O, LEU277O, LEU281N, LEU281O, LEU286O, LEU28O, LEU290O, LEU329O, LEU32O, LEU333N, LEU334O, LEU339N, LEU353N, LEU354N, LEU357N, LEU365N, LYS130O, LYS257O, LYS337N, MET130N, MET240N, MET253O, MET265N, MET301O, MET347N, MET351N, MET363N, PHE359N, PRO135O, PRO148O, PRO166O, PRO242O, PRO283O, PRO330O, PRO332O, PRO340N, PRO343N, PRO364N, PRO366N, PRO368N, SER157O, SER194O, SER213N, SER219N, SER227N, SER238N, SER282O, SER284O, SER302O, SER97N, THR154O, THR157N, THR221N, THR243N, THR250O, THR266O, THR331N, THR352N, THR99N, TRP247O, TRP278N, TYR163O, TYR341N, VAL237N, VAL264N, VAL265O, VAL293O, VAL331O, VAL5N, VAL90O