3GLG

crystal structure of a mutant (gammat157a) e. coli clamp loader bound to primer-template dna

• Total interactions analyzed: 91
• Total true interactions: 20
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 233
  • Norm. En. per Res.: -3.2161
• Hub Node: B(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-47.7247	-66.6552	-225.534	-339.914	144	8	6	11008	8	36	25
A-E	-23.1071	-24.0404	-183.284	-230.4314	76	9	3	8358	5	21	13
B-C	-100.0123	-111.8421	-579.091	-790.9455	257	57	12	25902	12	94	81
B-D	0.0	0.0	-0.2059	-0.2059	7	0	0	50	0	2	0
B-E	0.0	1.9828	-0.9394	1.0434	5	0	0	156	0	1	2
C-D	-98.8577	-93.1694	-512.314	-704.3411	226	47	8	23442	16	76	78
C-E	0.0	1.3428	-9.3864	-8.0437	8	5	0	537	0	1	2
D-E	-57.0052	-142.524	-460.248	-659.7772	227	31	6	20827	14	97	97
D-I	0.0	15.6157	-0.5428	15.073	2	0	0	22	0	2	1
D-J	0.0	0.0	-38.082	-38.082	35	11	0	1894	0	10	7
E-I	0.0	0.0	-21.7861	-21.7861	31	0	0	1131	0	9	1
E-J	-22.0781	34.1344	-147.456	-135.3997	73	8	0	5874	0	4	21
F-G	-27.6517	-61.2103	-223.059	-311.9211	145	13	7	10980	7	35	24
F-J	-28.6445	-22.202	-185.294	-236.1404	76	18	4	8575	5	20	14
G-H	-100.0707	-86.3345	-605.173	-791.5782	276	63	12	27560	12	94	88
G-I	0.0	0.0	-0.409	-0.409	8	0	0	77	0	3	1
G-J	0.0	2.3268	-1.1048	1.2221	6	0	0	201	0	1	2
H-I	-93.3959	-95.4124	-560.553	-749.3613	233	60	9	24760	16	78	81
H-J	0.0	1.3024	-7.47	-6.1677	7	5	0	467	0	1	1
I-J	-88.3885	-145.8403	-468.388	-702.6168	230	30	7	21384	14	99	97

Interface residues

• A-B: ALA180A, ALA182A, ALA184A, ALA205A, ALA209A, ALA210A, ALA27B, ALA280B, ALA293B, ALA29B, ALA300B, ALA301B, ALA322A, ALA40B, ARG113A, ARG169B, ARG187A, ARG201A, ARG228A, ARG237A, ARG291B, ARG307A, ARG314B, ARG336B, ARG36B, ARG39A, ASN159A, ASN177A, ASN207A, ASN26A, ASN304B, ASN30B, ASP194A, ASP208A, ASP27A, ASP305B, ASP315A, ASP36A, CYS170B, CYS173A, CYS332A, GLN160B, GLN172B, GLN183A, GLN204A, GLN21B, GLN234A, GLN235A, GLN296B, GLN318A, GLN326B, GLN32A, GLN35A, GLU144B, GLU145B, GLU186A, GLU203A, GLU22B, GLU239A, GLU279B, GLU323A, GLU325A, GLU33A, GLY240A, GLY287B, GLY303B, GLY317A, GLY31B, GLY326A, HIS174B, HIS211A, HIS231A, HIS23B, HIS290B, HIS333A, HIS38B, HIS39B, HIS50A, ILE166B, ILE37B, LEU140B, LEU158A, LEU160A, LEU167B, LEU171B, LEU175B, LEU179A, LEU185A, LEU188A, LEU190A, LEU191A, LEU230A, LEU233A, LEU238A, LEU25B, LEU28B, LEU297B, LEU29A, LEU302B, LEU304A, LEU31A, LEU324A, LEU327A, LEU329A, LEU32B, LEU330A, LEU333B, LEU34B, LEU42B, LYS141B, LYS176B, LYS227A, MET294B, MET306B, PHE173B, PRO163B, PRO193A, PRO28A, PRO299B, SER168B, SER189A, SER226A, SER241A, SER298B, SER319A, SER328A, SER44B, THR165B, THR26B, THR311A, THR52A, TRP192A, TRP321A, TYR172A, TYR174A, TYR316A, TYR329B, TYR41B, VAL164B, VAL202A, VAL206A, VAL24B, VAL283B, VAL295B
• A-E: ALA301A, ARG248A, ARG252A, ARG262A, ARG299A, ARG307A, ARG308E, ARG318E, ASN237E, ASN259A, ASN307E, ASP228E, ASP314E, ASP315A, GLN251A, GLN263A, GLN295A, GLN299E, GLN300A, GLN303A, GLN314A, GLN324E, GLU298E, GLU309A, GLU309E, GLU320E, GLY227E, GLY305E, HIS266A, HIS276A, HIS295E, HIS321E, ILE296E, ILE306E, ILE312E, ILE319E, LEU232E, LEU233E, LEU247A, LEU250A, LEU254A, LEU255A, LEU256A, LEU257A, LEU260A, LEU298A, LEU300E, LEU304A, LEU305A, LEU310A, LEU310E, LEU311E, LEU312A, LEU315E, LEU316E, LEU317E, LEU327A, LYS313A, SER231E, SER302E, THR296A, THR304E, THR306A, THR308A, THR311A, THR313E, TRP229E, TYR222E, TYR230E, TYR316A, TYR322E, VAL244A, VAL258A, VAL302A, VAL303E, VAL327E
• B-C: ALA138C, ALA155B, ALA157B, ALA157C, ALA177C, ALA209B, ALA210B, ALA217B, ALA224B, ALA226B, ALA239B, ALA259B, ALA266B, ALA271B, ALA272B, ALA273B, ALA27C, ALA280B, ALA280C, ALA293C, ALA29C, ALA300C, ALA301C, ALA317C, ALA342B, ALA356B, ALA358B, ALA40C, ALA55B, ALA7B, ALA95B, ALA96B, ARG105C, ARG11B, ARG133B, ARG133C, ARG169C, ARG208C, ARG215B, ARG263B, ARG274B, ARG291C, ARG318C, ARG336B, ARG336C, ARG345B, ARG346B, ARG355B, ARG362C, ARG36C, ARG47B, ARG47C, ARG56B, ARG86B, ARG8B, ARG98B, ASN137C, ASN260B, ASN269B, ASN30C, ASP103B, ASP109C, ASP126B, ASP158B, ASP158C, ASP179C, ASP216B, ASP222B, ASP229B, ASP245B, ASP246B, ASP324C, ASP344B, ASP94B, CYS170C, GLN112C, GLN160C, GLN172C, GLN223B, GLN231B, GLN248B, GLN296C, GLN326C, GLN330C, GLU102C, GLU127B, GLU144C, GLU145C, GLU148C, GLU194B, GLU211B, GLU211C, GLU22C, GLU262B, GLU270B, GLU277B, GLU279C, GLU284B, GLU284C, GLU338B, GLU338C, GLU350B, GLU367B, GLU92B, GLY212C, GLY228B, GLY230B, GLY242B, GLY261B, GLY275B, GLY287C, GLY31C, GLY335B, GLY335C, GLY348B, GLY35C, GLY45B, GLY45C, GLY48B, HIS129B, HIS134C, HIS174C, HIS195B, HIS23C, HIS290C, HIS38C, HIS39C, ILE125B, ILE166C, ILE190B, ILE196B, ILE225B, ILE268B, ILE276B, ILE292C, ILE320C, ILE325C, ILE334B, ILE334C, ILE37C, ILE93B, LEU108C, LEU124B, LEU131B, LEU139C, LEU140C, LEU143C, LEU167C, LEU171C, LEU175C, LEU178C, LEU191B, LEU214B, LEU218B, LEU220B, LEU244B, LEU25C, LEU282C, LEU286C, LEU288C, LEU289C, LEU28C, LEU297C, LEU316C, LEU327C, LEU32C, LEU332C, LEU333C, LEU339B, LEU339C, LEU34C, LEU353B, LEU354B, LEU357B, LEU365B, LEU42C, LEU6B, LYS100B, LYS141C, LYS151C, LYS161B, LYS176C, LYS337B, LYS337C, LYS51B, LYS9B, MET130B, MET240B, MET265B, MET285C, MET294C, MET306C, MET347B, MET351B, PHE136C, PHE173C, PHE359B, PHE43C, PRO146C, PRO147C, PRO159C, PRO163C, PRO299C, PRO321C, PRO322C, PRO340B, PRO340C, PRO343B, PRO364B, PRO366B, PRO368B, SER132B, SER132C, SER135C, SER168C, SER213B, SER219B, SER227B, SER298C, SER33C, SER44C, SER53B, SER97B, THR104C, THR142C, THR156B, THR165C, THR221B, THR243B, THR26C, THR319C, THR323C, THR331C, THR352B, THR46B, THR46C, THR52B, THR99B, TRP10B, TRP278B, TYR328C, TYR329C, TYR341B, TYR341C, TYR41C, VAL101C, VAL128B, VAL150C, VAL164C, VAL180C, VAL24C, VAL264B, VAL283C, VAL295C, VAL349B, VAL49C, VAL5B
• B-D: ARG345B, GLN160D, GLU277B, LYS337D, PRO340B, TYR341B, VAL164D
• B-E: GLU338B, HIS333E, LEU334E, LYS337B, TYR341B
• C-D: ALA138D, ALA155C, ALA157C, ALA177D, ALA217C, ALA224C, ALA226C, ALA239C, ALA259C, ALA266C, ALA27D, ALA293D, ALA29D, ALA301D, ALA317D, ALA342C, ALA356C, ALA358C, ALA40D, ALA55C, ALA7C, ALA95C, ALA96C, ARG105D, ARG11C, ARG133C, ARG133D, ARG169D, ARG208D, ARG215C, ARG263C, ARG291D, ARG318D, ARG336C, ARG336D, ARG345C, ARG346C, ARG355C, ARG362D, ARG36D, ARG47C, ARG56C, ARG8C, ARG98C, ASN137D, ASN260C, ASN269C, ASN30D, ASP103C, ASP109D, ASP126C, ASP158C, ASP216C, ASP222C, ASP229C, ASP324D, ASP344C, ASP94C, CYS170D, GLN160D, GLN172D, GLN223C, GLN231C, GLN296D, GLN326D, GLN330D, GLN4C, GLU102D, GLU127C, GLU144D, GLU145D, GLU148D, GLU194C, GLU211C, GLU211D, GLU262C, GLU277C, GLU279D, GLU284D, GLU338C, GLU338D, GLU350C, GLU367C, GLU92C, GLY228C, GLY230C, GLY242C, GLY261C, GLY275C, GLY287D, GLY31D, GLY335C, GLY335D, GLY348C, GLY35D, GLY45C, GLY48C, HIS129C, HIS134D, HIS149D, HIS174D, HIS195C, HIS23D, HIS290D, HIS360C, HIS38D, HIS39D, ILE125C, ILE166D, ILE190C, ILE196C, ILE225C, ILE268C, ILE276C, ILE292D, ILE320D, ILE325D, ILE334C, ILE334D, ILE37D, ILE93C, LEU108D, LEU124C, LEU131C, LEU139D, LEU140D, LEU143D, LEU167D, LEU171D, LEU191C, LEU214C, LEU218C, LEU220C, LEU282D, LEU286D, LEU288D, LEU289D, LEU28D, LEU297D, LEU316D, LEU327D, LEU32D, LEU332D, LEU333D, LEU339C, LEU339D, LEU34D, LEU353C, LEU354C, LEU357C, LEU365C, LEU42D, LEU6C, LYS100C, LYS141D, LYS151D, LYS161C, LYS176D, LYS337C, LYS337D, LYS51C, LYS9C, MET130C, MET240C, MET265C, MET285D, MET294D, MET347C, MET351C, PHE120D, PHE136D, PHE173D, PHE359C, PRO146D, PRO147D, PRO163D, PRO299D, PRO321D, PRO322D, PRO340C, PRO340D, PRO343C, PRO364C, PRO366C, PRO368C, SER132C, SER132D, SER135D, SER168D, SER213C, SER219C, SER227C, SER298D, SER33D, SER53C, SER97C, THR104D, THR142D, THR156C, THR165D, THR221C, THR26D, THR319D, THR323D, THR331C, THR331D, THR352C, THR46C, THR46D, THR52C, THR99C, TRP10C, TYR328D, TYR329D, TYR341C, TYR341D, TYR41D, VAL101D, VAL150D, VAL164D, VAL24D, VAL264C, VAL283D, VAL295D, VAL349C, VAL5C
• C-E: GLU338C, HIS333E, ILE334C, LEU334E, LEU339C, LYS337C, PRO340C, TYR341C
• D-E: ALA123E, ALA124E, ALA125E, ALA127E, ALA137E, ALA153E, ALA155D, ALA157D, ALA165E, ALA16E, ALA195E, ALA20E, ALA210D, ALA217D, ALA224D, ALA226D, ALA239D, ALA243E, ALA249E, ALA255E, ALA259D, ALA262E, ALA263E, ALA266D, ALA26E, ALA272D, ALA273D, ALA288E, ALA342D, ALA356D, ALA358D, ALA7D, ALA95D, ALA96D, ARG11D, ARG146E, ARG150E, ARG156E, ARG158E, ARG160E, ARG192E, ARG215D, ARG22E, ARG258E, ARG263D, ARG297E, ARG336D, ARG345D, ARG346D, ARG355D, ARG47D, ARG56D, ARG8D, ARG94E, ARG98D, ASN126E, ASN260D, ASN269D, ASP103D, ASP122E, ASP126D, ASP158D, ASP216D, ASP222D, ASP229D, ASP254E, ASP292E, ASP344D, ASP91E, ASP94D, CYS159E, CYS294E, GLN223D, GLN264E, GLN287E, GLN299E, GLN30E, GLN330D, GLN4D, GLU127D, GLU133E, GLU134E, GLU138E, GLU147E, GLU149E, GLU169E, GLU194D, GLU211D, GLU262D, GLU277D, GLU279D, GLU298E, GLU338D, GLU350D, GLU92D, GLU98E, GLY196E, GLY21E, GLY228D, GLY230D, GLY23E, GLY261D, GLY261E, GLY275D, GLY291E, GLY335D, GLY348D, GLY45D, GLY48D, HIS129D, HIS162E, HIS246E, HIS24E, HIS259E, HIS25E, HIS260E, HIS295E, HIS333E, HIS360D, ILE125D, ILE196D, ILE225D, ILE268D, ILE276D, ILE289E, ILE334D, ILE93D, LEU124D, LEU128E, LEU129E, LEU132E, LEU14E, LEU151E, LEU152E, LEU155E, LEU161E, LEU193E, LEU214D, LEU218D, LEU220D, LEU241D, LEU245E, LEU252E, LEU256E, LEU267D, LEU27E, LEU286E, LEU290E, LEU329E, LEU32E, LEU333D, LEU334E, LEU339D, LEU353D, LEU354D, LEU357D, LEU6D, LYS100D, LYS130E, LYS13E, LYS161D, LYS257E, LYS337D, LYS51D, LYS9D, MET130D, MET240D, MET253E, MET265D, MET301E, MET347D, MET351D, PHE359D, PRO135E, PRO136E, PRO148E, PRO166E, PRO168E, PRO242E, PRO283E, PRO330E, PRO332E, PRO33E, PRO340D, PRO343D, SER157E, SER17E, SER194E, SER213D, SER219D, SER227D, SER284E, SER2D, SER302E, SER53D, SER97D, THR121E, THR131E, THR139E, THR154E, THR156D, THR221D, THR250E, THR266E, THR331D, THR352D, THR46D, THR52D, THR97E, THR99D, TRP140E, TRP247E, TRP278D, TYR163E, TYR18E, TYR341D, TYR3D, VAL128D, VAL264D, VAL265E, VAL293E, VAL331E, VAL349D, VAL49D, VAL5D, VAL90E, VAL93E
• D-I: GLU262D, GLU262I
• D-J: ALA221J, ALA259D, ALA275J, ALA278J, ALA358D, ARG258J, ARG362D, ASN260D, ASN279J, ASP269J, CYS217J, GLN218J, GLU258D, GLU262D, GLU276J, GLY261D, GLY261J, GLY272J, HIS260J, HIS280J, HIS360D, LEU220J, LEU273J, LEU277J, LEU357D, MET363D, PHE359D, PRO225J, PRO271J, PRO361D, SER223J, TYR222J, VAL224J, VAL270J, VAL274J
• E-I: ALA221E, ALA259I, ALA275E, ALA278E, ALA358I, ARG258E, ARG362I, ASN279E, ASP269E, CYS217E, GLN218E, GLU262I, GLU276E, GLY261E, GLY261I, GLY272E, HIS280E, HIS360I, LEU220E, LEU273E, LEU277E, LEU357I, MET363I, PHE359I, PRO225E, PRO271E, PRO361I, TYR222E, VAL224E, VAL270E, VAL274E
• E-J: ALA275E, ALA275J, ALA278E, ALA278J, ALA288E, ARG258E, ARG258J, ARG285E, ARG285J, ASN279E, ASN279J, ASP228E, ASP228J, GLN287E, GLN287J, GLN324E, GLN324J, GLU276E, GLU276J, GLU320E, GLU320J, GLY227E, GLY227J, GLY261E, GLY261J, GLY326E, GLY326J, HIS259E, HIS259J, HIS260E, HIS260J, HIS280E, HIS280J, HIS321E, HIS321J, ILE319E, ILE319J, LEU256E, LEU256J, LEU277E, LEU277J, LEU281E, LEU281J, LEU286E, LEU286J, LEU323E, LEU323J, LEU329E, LEU329J, PRO225E, PRO225J, PRO283E, PRO283J, PRO325E, PRO325J, SER223E, SER223J, SER226E, SER226J, SER282E, SER282J, SER284E, SER284J, TRP229E, TRP229J, TYR322E, TYR322J, VAL224E, VAL224J, VAL327E, VAL327J, VAL328E, VAL328J
• F-G: ALA180F, ALA182F, ALA184F, ALA205F, ALA209F, ALA27G, ALA280G, ALA293G, ALA29G, ALA300G, ALA301G, ALA322F, ALA40G, ARG113F, ARG169G, ARG187F, ARG201F, ARG228F, ARG237F, ARG291G, ARG307F, ARG314G, ARG336G, ARG36G, ARG39F, ASN159F, ASN177F, ASN207F, ASN304G, ASN30G, ASP158G, ASP194F, ASP208F, ASP27F, ASP305G, ASP315F, ASP36F, CYS170G, CYS332F, GLN160G, GLN172G, GLN183F, GLN204F, GLN21G, GLN234F, GLN235F, GLN296G, GLN318F, GLN326G, GLN32F, GLN35F, GLU144G, GLU145G, GLU186F, GLU203F, GLU22G, GLU239F, GLU279G, GLU323F, GLU325F, GLU33F, GLY240F, GLY287G, GLY303G, GLY317F, GLY31G, GLY326F, GLY35G, HIS174G, HIS211F, HIS231F, HIS23G, HIS290G, HIS333F, HIS38G, HIS39G, HIS50F, ILE166G, ILE37G, LEU140G, LEU158F, LEU160F, LEU167G, LEU171G, LEU175G, LEU179F, LEU185F, LEU188F, LEU190F, LEU191F, LEU230F, LEU233F, LEU236F, LEU238F, LEU25G, LEU28G, LEU297G, LEU29F, LEU302G, LEU304F, LEU324F, LEU327F, LEU329F, LEU32G, LEU330F, LEU331F, LEU333G, LEU34G, LEU42G, LYS141G, LYS161G, LYS176G, LYS227F, MET294G, MET306G, PHE173G, PRO163G, PRO193F, PRO28F, PRO299G, SER168G, SER189F, SER226F, SER241F, SER298G, SER319F, SER328F, SER33G, SER44G, THR165G, THR26G, THR311F, THR52F, TRP192F, TRP321F, TYR172F, TYR174F, TYR329G, TYR41G, VAL164G, VAL202F, VAL206F, VAL24G, VAL283G, VAL295G
• F-J: ALA301F, ARG248F, ARG252F, ARG262F, ARG299F, ARG307F, ARG308J, ARG318J, ASN237J, ASN259F, ASN307J, ASP228J, ASP314J, ASP315F, GLN251F, GLN263F, GLN295F, GLN299J, GLN300F, GLN303F, GLN314F, GLN324J, GLU298J, GLU309F, GLU309J, GLU320J, GLY227J, GLY305J, HIS266F, HIS276F, HIS295J, HIS321J, ILE296J, ILE306J, ILE312J, ILE319J, LEU232J, LEU233J, LEU247F, LEU250F, LEU254F, LEU255F, LEU256F, LEU260F, LEU298F, LEU300J, LEU304F, LEU305F, LEU310F, LEU310J, LEU311J, LEU312F, LEU315J, LEU316J, LEU317J, LEU327F, LYS313F, SER226J, SER231J, SER302J, THR296F, THR304J, THR306F, THR308F, THR311F, THR313J, TRP229J, TYR222J, TYR230J, TYR316F, TYR322J, VAL244F, VAL258F, VAL302F, VAL303J, VAL327J
• G-H: ALA138H, ALA155G, ALA157G, ALA157H, ALA177H, ALA209G, ALA209H, ALA210G, ALA217G, ALA224G, ALA226G, ALA239G, ALA259G, ALA266G, ALA271G, ALA272G, ALA273G, ALA27H, ALA280G, ALA280H, ALA293H, ALA29H, ALA300H, ALA301H, ALA317H, ALA342G, ALA356G, ALA358G, ALA40H, ALA55G, ALA70H, ALA7G, ALA95G, ALA96G, ARG105H, ARG11G, ARG133H, ARG169H, ARG208H, ARG215G, ARG263G, ARG274G, ARG291H, ARG318H, ARG336G, ARG336H, ARG345G, ARG346G, ARG355G, ARG362H, ARG36H, ARG47G, ARG47H, ARG56G, ARG86G, ARG8G, ARG98G, ASN137H, ASN260G, ASN269G, ASN30H, ASP103G, ASP109H, ASP126G, ASP158G, ASP158H, ASP179H, ASP216G, ASP222G, ASP229G, ASP245G, ASP246G, ASP324H, ASP344G, ASP94G, CYS170H, GLN-3G, GLN112H, GLN160H, GLN172H, GLN21H, GLN223G, GLN231G, GLN248G, GLN296H, GLN326H, GLN330H, GLN4G, GLU-7G, GLU102H, GLU127G, GLU144H, GLU145H, GLU148H, GLU194G, GLU211G, GLU211H, GLU262G, GLU270G, GLU277G, GLU279H, GLU284G, GLU284H, GLU338G, GLU338H, GLU350G, GLU367G, GLU92G, GLY-2G, GLY-9G, GLY212H, GLY228G, GLY230G, GLY242G, GLY261G, GLY275G, GLY287H, GLY31H, GLY335G, GLY335H, GLY348G, GLY35H, GLY45G, GLY45H, GLY48G, GLY67H, HIS0G, HIS129G, HIS134H, HIS174H, HIS195G, HIS23H, HIS290H, HIS38H, HIS39H, ILE125G, ILE166H, ILE190G, ILE196G, ILE225G, ILE268G, ILE276G, ILE292H, ILE320H, ILE325H, ILE334G, ILE334H, ILE37H, ILE68H, ILE93G, LEU108H, LEU124G, LEU131G, LEU139H, LEU140H, LEU143H, LEU167H, LEU171H, LEU175H, LEU178H, LEU191G, LEU214G, LEU218G, LEU220G, LEU244G, LEU25H, LEU282H, LEU286H, LEU288H, LEU289H, LEU28H, LEU297H, LEU316H, LEU327H, LEU32H, LEU332H, LEU333H, LEU339G, LEU339H, LEU34H, LEU353G, LEU354G, LEU357G, LEU365G, LEU42H, LEU62H, LEU6G, LYS100G, LYS141H, LYS151H, LYS161G, LYS176H, LYS337G, LYS337H, LYS51G, LYS9G, MET130G, MET1G, MET240G, MET265G, MET285H, MET294H, MET306H, MET347G, MET351G, PHE120H, PHE136H, PHE173H, PHE359G, PHE43H, PRO-1G, PRO146H, PRO147H, PRO159H, PRO163H, PRO299H, PRO321H, PRO322H, PRO340G, PRO340H, PRO343G, PRO364G, PRO366G, PRO368G, SER132G, SER132H, SER135H, SER168H, SER213G, SER219G, SER227G, SER298H, SER2G, SER33H, SER44H, SER53G, SER97G, THR104H, THR142H, THR156G, THR165H, THR221G, THR243G, THR26H, THR319H, THR323H, THR331H, THR352G, THR46G, THR46H, THR52G, THR69H, THR71H, THR99G, TRP10G, TRP278G, TYR328H, TYR329H, TYR341G, TYR341H, TYR3G, TYR41H, VAL-6G, VAL101H, VAL128G, VAL150H, VAL164H, VAL180H, VAL24H, VAL264G, VAL283H, VAL295H, VAL349G, VAL49G, VAL49H, VAL5G
• G-I: ARG345G, GLN160I, GLU277G, GLY275G, LYS337I, PRO340G, TYR341G, VAL164I
• G-J: GLU338G, HIS333J, ILE334G, LEU334J, LYS337G, TYR341G
• H-I: ALA138I, ALA155H, ALA157H, ALA177I, ALA217H, ALA224H, ALA226H, ALA236H, ALA239H, ALA259H, ALA266H, ALA27I, ALA293I, ALA29I, ALA301I, ALA317I, ALA342H, ALA356H, ALA358H, ALA40I, ALA55H, ALA7H, ALA95H, ALA96H, ARG105I, ARG11H, ARG133H, ARG133I, ARG169I, ARG208I, ARG215H, ARG263H, ARG274H, ARG291I, ARG318I, ARG336H, ARG336I, ARG345H, ARG346H, ARG355H, ARG362I, ARG36I, ARG47H, ARG47I, ARG56H, ARG8H, ARG98H, ASN137I, ASN260H, ASN269H, ASN30I, ASP103H, ASP109I, ASP126H, ASP158H, ASP179I, ASP216H, ASP222H, ASP229H, ASP324I, ASP344H, ASP94H, CYS170I, GLN160I, GLN172I, GLN223H, GLN231H, GLN296I, GLN326I, GLN330I, GLN4H, GLU102I, GLU127H, GLU144I, GLU145I, GLU148I, GLU194H, GLU211H, GLU211I, GLU22I, GLU262H, GLU277H, GLU279I, GLU284I, GLU315I, GLU338H, GLU338I, GLU350H, GLU367H, GLU92H, GLY228H, GLY230H, GLY242H, GLY261H, GLY275H, GLY287I, GLY31I, GLY335H, GLY335I, GLY348H, GLY35I, GLY45H, GLY48H, HIS129H, HIS134I, HIS149I, HIS174I, HIS195H, HIS23I, HIS290I, HIS360H, HIS38I, HIS39I, ILE125H, ILE166I, ILE190H, ILE196H, ILE225H, ILE268H, ILE276H, ILE292I, ILE320I, ILE325I, ILE334H, ILE334I, ILE37I, ILE93H, LEU108I, LEU124H, LEU131H, LEU139I, LEU140I, LEU143I, LEU167I, LEU171I, LEU191H, LEU214H, LEU218H, LEU220H, LEU282I, LEU286I, LEU288I, LEU289I, LEU28I, LEU297I, LEU316I, LEU327I, LEU32I, LEU332I, LEU333I, LEU339H, LEU339I, LEU34I, LEU353H, LEU354H, LEU357H, LEU365H, LEU42I, LEU6H, LYS100H, LYS141I, LYS151I, LYS161H, LYS176I, LYS337H, LYS337I, LYS51H, LYS9H, MET130H, MET240H, MET265H, MET285I, MET294I, MET347H, MET351H, PHE120I, PHE136I, PHE173I, PHE359H, PRO146I, PRO147I, PRO163I, PRO299I, PRO321I, PRO322I, PRO340H, PRO340I, PRO343H, PRO364H, PRO366H, PRO368H, SER132H, SER132I, SER135I, SER168I, SER213H, SER219H, SER227H, SER298I, SER33I, SER53H, SER97H, THR142I, THR156H, THR165I, THR221H, THR26I, THR319I, THR323I, THR331H, THR331I, THR352H, THR46H, THR46I, THR52H, THR99H, TRP10H, TYR328I, TYR329I, TYR341H, TYR341I, TYR41I, VAL101I, VAL150I, VAL164I, VAL180I, VAL24I, VAL264H, VAL283I, VAL295I, VAL349H, VAL49H, VAL5H
• H-J: GLU149J, GLU338H, HIS333J, ILE334H, LEU334J, LYS337H, TYR341H
• I-J: ALA123J, ALA124J, ALA125J, ALA127J, ALA137J, ALA153J, ALA155I, ALA157I, ALA165J, ALA16J, ALA195J, ALA20J, ALA210I, ALA217I, ALA224I, ALA226I, ALA239I, ALA243J, ALA249J, ALA255J, ALA259I, ALA262J, ALA263J, ALA266I, ALA26J, ALA272I, ALA273I, ALA288J, ALA342I, ALA356I, ALA358I, ALA7I, ALA95I, ALA96I, ARG11I, ARG146J, ARG150J, ARG156J, ARG158J, ARG160J, ARG192J, ARG215I, ARG22J, ARG258J, ARG263I, ARG297J, ARG336I, ARG345I, ARG346I, ARG355I, ARG47I, ARG56I, ARG8I, ARG94J, ARG98I, ASN126J, ASN260I, ASN269I, ASP103I, ASP122J, ASP126I, ASP158I, ASP216I, ASP222I, ASP229I, ASP254J, ASP292J, ASP344I, ASP91J, ASP94I, CYS159J, CYS294J, GLN223I, GLN231I, GLN264J, GLN287J, GLN299J, GLN30J, GLN330I, GLN4I, GLU127I, GLU133J, GLU134J, GLU138J, GLU147J, GLU149J, GLU169J, GLU194I, GLU211I, GLU262I, GLU277I, GLU279I, GLU298J, GLU338I, GLU350I, GLU92I, GLU98J, GLY196J, GLY21J, GLY228I, GLY230I, GLY23J, GLY242I, GLY261I, GLY261J, GLY275I, GLY291J, GLY335I, GLY348I, GLY45I, GLY48I, HIS129I, HIS162J, HIS246J, HIS24J, HIS259J, HIS25J, HIS260J, HIS295J, HIS333J, HIS360I, ILE125I, ILE196I, ILE225I, ILE268I, ILE276I, ILE289J, ILE334I, ILE93I, LEU124I, LEU128J, LEU129J, LEU132J, LEU14J, LEU151J, LEU152J, LEU155J, LEU161J, LEU193J, LEU214I, LEU218I, LEU220I, LEU241I, LEU245J, LEU252J, LEU256J, LEU267I, LEU27J, LEU286J, LEU28J, LEU290J, LEU329J, LEU32J, LEU333I, LEU334J, LEU339I, LEU353I, LEU354I, LEU357I, LEU6I, LYS100I, LYS130J, LYS13J, LYS161I, LYS257J, LYS337I, LYS51I, LYS9I, MET130I, MET240I, MET253J, MET265I, MET301J, MET347I, MET351I, PHE141J, PHE359I, PRO135J, PRO136J, PRO148J, PRO166J, PRO168J, PRO242J, PRO283J, PRO330J, PRO332J, PRO340I, PRO343I, SER157J, SER17J, SER194J, SER213I, SER219I, SER227I, SER284J, SER2I, SER302J, SER53I, SER97I, THR121J, THR131J, THR139J, THR154J, THR156I, THR221I, THR250J, THR266J, THR331I, THR352I, THR46I, THR52I, THR97J, THR99I, TRP140J, TRP247J, TYR163J, TYR18J, TYR341I, TYR3I, VAL128I, VAL15J, VAL264I, VAL265J, VAL293J, VAL331J, VAL349I, VAL49I, VAL5I, VAL90J, VAL93J