3GJO

crystal structure of human eb1 in complex with microtubule tip localization signal peptide of macf

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 38
  • Norm. En. per Res.: -6.0861
• Hub Node: B(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-45.8918	-37.7656	-470.573	-554.2303	123	16	35	20101	4	51	68
A-C	0.0	0.0	-0.1788	-0.1788	6	0	0	31	0	0	0
A-E	-38.5861	-9.2622	-183.422	-231.2703	38	6	3	6260	0	13	2
A-F	0.0	0.0	-28.5073	-28.5073	16	1	0	1214	0	0	1
B-C	0.0	13.1071	-55.0523	-41.9452	30	1	3	2668	0	9	8
B-D	0.0	0.0	-1.1824	-1.1824	8	0	0	149	0	2	5
B-E	-9.5273	-4.0325	-26.0263	-39.586	18	2	0	1182	0	5	3
B-F	-27.201	-2.8608	-169.27	-199.3317	37	7	2	5947	0	8	2
B-H	0.0	0.0	-1.6148	-1.6148	4	0	0	97	0	0	0
C-D	-56.5879	-73.2864	-453.893	-583.7674	116	20	33	19346	4	46	55
C-E	0.0	0.209	-21.3439	-21.1349	13	0	0	995	0	4	3
C-G	-43.4051	-3.4543	-165.995	-212.8544	37	6	3	5941	0	5	1
C-H	0.0	0.0	-15.9429	-15.9429	10	0	0	739	0	0	1
D-E	0.0	0.0	-0.0296	-0.0296	4	0	0	18	0	1	0
D-G	0.0	0.0	-25.8907	-25.8907	15	0	0	1066	0	0	1
D-H	-9.3654	-0.867	-73.9792	-84.2116	24	3	3	2768	0	2	1

Interface residues

• A-B: ALA193A, ALA193B, ALA194A, ALA194B, ALA248A, ALA248B, ARG214A, ARG214B, ARG222A, ARG222B, ARG241A, ARG241B, ASN201A, ASN201B, ASN223A, ASN223B, ASN231A, ASN231B, ASP209A, ASP209B, ASP215A, ASP215B, ASP236A, ASP236B, ASP244A, ASP244B, ASP250A, ASP250B, CB8.505514.46801, CYS228A, CYS228B, GLN198A, GLN198B, GLN199A, GLN199B, GLN240A, GLN240B, GLU192A, GLU192A5, GLU192B, GLU195A, GLU195B, GLU208A, GLU208B, GLU211A, GLU211B, GLU213A, GLU213B, GLU225A, GLU225B, GLU230A, GLU230B, GLU234A, GLU251A, GLU251B, GLY219A, GLY219B, GLY252A, GLY252B, ILE224A, ILE224B, ILE227A, ILE227B, ILE242A, ILE242B, ILE245A, ILE245B, ILE255A, ILE255B, LEU196A, LEU196B, LEU203A, LEU203B, LEU205A, LEU205B, LEU210A, LEU210B, LEU221A, LEU221B, LEU226A, LEU226B, LEU239A, LEU239B, LEU246A, LEU246B, LYS204A, LYS204B, LYS212A, LYS212B, LYS220A, LYS220B, MET197A, MET197B, PHE216A, PHE216B, PHE218A, PHE218B, PHE253A, PHE253B, PRO237A, PRO237B, PRO256A, PRO256B, THR206A, THR206B, THR249A, THR249B, TYR217A, TYR217B, TYR247A, TYR247B, VAL200A, VAL200B, VAL202A, VAL202B, VAL207A, VAL207B, VAL238A, VAL238B, VAL243A, VAL243B, VAL254A, VAL254B
• A-C: GLN198C, GLU208A, GLU211A, LYS204A, VAL202C, VAL207A
• A-E: ALA248A, ARG214A, ARG222A, ARG5484E, ASN223A, ASP244A, ASP250A, ASP257A, GLN229A, GLN5483E, GLU225A, GLU232A, GLU251A, GLY219A, GLY252A, ILE224A, ILE245A, ILE255A, ILE5479E, LEU221A, LEU226A, LEU246A, LYS220A, LYS5475E, LYS5478E, PHE218A, PHE253A, PRO256A, PRO5476E, PRO5480E, PRO5482E, SER5477E, THR249A, THR5481E, TYR217A, TYR247A, VAL243A, VAL254A
• A-F: ARG214A, ASP209A, GLN5483F, GLU213A, ILE224A, ILE5479F, LEU210A, LEU221A, LYS212A, LYS220A, LYS5478F, PHE216A, PRO5480F, PRO5482F, THR5481F, TYR217A
• B-C: ASN201B, ASN201C, ASP209B, ASP209C, GLN198B, GLN198C, GLN199B, GLU208B, GLU208C, GLU211C, GLU213C, LEU203B, LEU203C, LEU205B, LEU205C, LEU210B, LEU210C, LYS204B, LYS204C, LYS212B, LYS212C, MET197B, THR206B, THR206C, TYR217C, VAL200B, VAL202B, VAL202C, VAL207B, VAL207C
• B-D: ALA194B, ARG214D, ASN201B, GLN198B, GLU195B, GLU211D, MET197B, VAL207D
• B-E: ARG214B, ASP209B, GLU213B, ILE224B, ILE5479E, LEU205B, LEU210B, LEU221B, LYS212B, LYS220B, LYS5478E, LYS5485E, PHE216B, PRO5480E, PRO5482E, THR206B, THR5481E, TYR217B
• B-F: ALA248B, ARG214B, ARG222B, ASN223B, ASP250B, CYS228B, GLN229B, GLN5483F, GLU225B, GLU230B, GLU232B, GLU251B, GLY219B, GLY252B, ILE224B, ILE245B, ILE255B, ILE5479F, LEU221B, LEU226B, LEU246B, LYS220B, LYS5475F, LYS5478F, PHE218B, PHE253B, PRO256B, PRO5476F, PRO5480F, PRO5482F, SER5477F, THR249B, THR5481F, TYR217B, TYR247B, VAL243B, VAL254B
• B-H: ALA194B, ASN201B, MET197B, THR5481H
• C-D: ALA193C, ALA193D, ALA194C, ALA194D, ALA248C, ALA248D, ARG214C, ARG214D, ARG222C, ARG222D, ARG241C, ARG241D, ASN201C, ASN201D, ASN223C, ASN223D, ASN231C, ASN231D, ASP209C, ASP209D, ASP215C, ASP215D, ASP236C, ASP236D, ASP244C, ASP244D, ASP250C, CYS228C, CYS228D, GLN198C, GLN198D, GLN199C, GLN199D, GLN229C, GLN240C, GLN240D, GLU192C, GLU192D, GLU195C, GLU195D, GLU208C, GLU208D, GLU211C, GLU211D, GLU213C, GLU213D, GLU225C, GLU225D, GLU230C, GLU230D, GLU232C, GLU234C, GLU251C, GLY219C, GLY219D, GLY252C, ILE224C, ILE224D, ILE227C, ILE227D, ILE242C, ILE242D, ILE245C, ILE245D, ILE255C, LEU196C, LEU196D, LEU203C, LEU203D, LEU205C, LEU205D, LEU210C, LEU210D, LEU221C, LEU221D, LEU226C, LEU226D, LEU239C, LEU239D, LEU246C, LEU246D, LYS204C, LYS204D, LYS212C, LYS212D, LYS220C, LYS220D, MET197C, MET197D, PHE216C, PHE216D, PHE218C, PHE218D, PHE253C, PRO237C, PRO237D, PRO256C, THR206C, THR206D, THR249C, THR249D, TYR217C, TYR217D, TYR247C, TYR247D, VAL200C, VAL200D, VAL202C, VAL202D, VAL207C, VAL207D, VAL238C, VAL238D, VAL243C, VAL243D, VAL254C
• C-E: ARG5484E, ASN201C, GLN5483E, GLU208C, LEU203C, LEU205C, LYS204C, LYS5485E, MET197C, THR206C, VAL200C, VAL202C, VAL207C
• C-G: ALA248C, ARG214C, ARG222C, ASN223C, ASP215C, ASP250C, CYS228C, GLN229C, GLN5483G, GLU211C, GLU225C, GLU232C, GLU251C, GLY219C, GLY252C, ILE224C, ILE245C, ILE255C, ILE5479G, LEU221C, LEU226C, LEU246C, LYS220C, LYS5478G, PHE218C, PHE253C, PRO256C, PRO5476G, PRO5480G, PRO5482G, SER5477G, THR249C, THR5481G, TYR217C, TYR247C, VAL243C, VAL254C
• C-H: GLU213C, ILE224C, ILE5479H, LEU221C, LYS220C, LYS5478H, PHE216C, PRO5480H, THR5481H, TYR217C
• D-E: ARG5484E, GLN199D, LEU203D, LYS5485E
• D-G: ARG214D, ASP209D, GLN5483G, GLU213D, ILE224D, ILE5479G, LEU210D, LYS212D, LYS220D, LYS5478G, PHE216D, PRO5480G, PRO5482G, THR5481G, TYR217D
• D-H: ALA248D, ARG214D, ARG222D, ASN223D, ASP244D, GLN229D, GLU225D, GLY219D, ILE224D, ILE245D, ILE5479H, LEU221D, LEU226D, LEU246D, LYS220D, LYS5478H, PHE218D, PRO5480H, SER5477H, THR249D, THR5481H, TYR217D, TYR247D, VAL243D