3GHG

crystal structure of human fibrinogen

• Total interactions analyzed: 190
• Total true interactions: 39
• Strongest Interaction:
  • Chains: H-S
  • Int. Res.: 44
  • Norm. En. per Res.: -5.6444
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-85.1403	-139.9673	585.6	360.4924	292	107	25	33414	9	94	78
A-C	-34.5453	-131.5913	1022.3	856.1635	219	37	21	20138	7	57	53
A-D	0.0	3.0666	658.601	661.6676	29	10	1	1528	0	11	8
A-E	-65.9098	14.0547	524.277	472.422	51	16	2	7398	0	14	11
A-F	0.0	0.0	-0.0961	-0.0961	6	0	0	22	0	0	0
B-C	-112.1393	-34.996	730.242	583.1067	318	70	27	31253	4	65	63
B-D	-55.3372	0.2316	538.704	483.5984	50	23	2	7367	0	13	11
B-E	0.0	0.0	-8.1731	-8.1731	18	0	1	447	0	3	2
B-F	0.0	0.0	-13.8275	-13.8275	30	0	0	986	0	2	3
B-O	-54.5315	-21.879	-116.576	-192.9865	45	15	0	4273	3	15	15
C-D	0.0	0.0	-1.0199	-1.0199	13	0	0	145	0	0	0
C-E	0.0	0.0	-24.9026	-24.9026	32	2	1	1355	0	3	2
C-F	-6.4546	0.0	-139.471	-145.9256	36	4	4	4633	0	2	2
C-M	-34.3559	-11.8297	-86.4691	-132.6547	41	14	0	3595	1	10	7
D-E	-27.8125	-99.249	839.349	712.2875	271	72	17	28497	6	89	69
D-F	-44.6898	-60.0044	1226.7	1122.0058	208	58	17	20165	6	59	49
E-F	-101.8747	-35.285	780.069	642.9092	311	79	29	30316	4	59	59
E-P	-47.703	-23.559	-127.975	-199.237	45	11	0	4128	4	15	14
F-K	0.0	0.0	-0.0192	-0.0192	2	0	0	12	0	1	1
F-N	-32.2287	-2.8085	-89.8435	-124.8807	47	9	0	4161	2	10	8
G-H	-85.6557	-102.0824	725.839	538.1009	283	71	23	31321	5	98	82
G-I	-26.4909	-71.9548	1191.25	1092.8042	209	63	19	18825	5	58	53
G-J	0.0	0.0	697.768	697.768	29	7	1	1474	0	11	7
G-K	-40.516	9.0395	517.724	486.2475	47	13	2	7377	0	12	11
G-L	0.0	0.0	-2.0307	-2.0307	13	0	0	212	0	2	4
H-I	-93.6651	-24.1435	680.769	562.9604	327	70	32	32937	3	65	67
H-J	-69.906	-12.9299	539.558	456.7221	48	28	2	7366	1	15	10
H-K	0.0	0.0	-1.9951	-1.9951	11	0	0	208	0	3	4
H-L	0.0	0.0	-18.4795	-18.4795	30	1	0	1150	0	3	6
H-S	-65.3065	-63.6351	-119.413	-248.3547	44	16	0	4193	4	15	14
I-J	0.0	0.0	-0.1624	-0.1624	7	0	0	32	0	0	0
I-K	0.0	0.0	-16.8773	-16.8773	32	2	0	1287	0	3	5
I-L	-19.3029	-4.9252	1323.09	1298.8619	59	24	7	7004	0	3	8
I-Q	-37.949	-1.5453	-119.386	-158.8803	47	10	0	4362	5	10	7
J-K	-80.3631	-140.4815	743.975	523.1303	291	99	21	32128	7	102	82
J-L	-20.1641	-113.0344	1164.71	1031.5116	202	78	8	17219	8	59	47
K-L	-133.9481	-82.0701	685.387	469.3688	324	70	30	32053	8	57	56
K-T	-55.1154	-39.4625	-127.631	-222.2089	44	9	0	4168	4	15	13
L-R	-46.4335	-26.1298	-115.206	-187.7692	48	8	0	4409	3	10	8

Interface residues

• A-B: ALA101A, ALA106B, ALA142A, ALA168A, ALA170A, ALA188B, ALA190A, ALA427B, ALA59B, ALA62B, ALA85B, ARG104A, ARG116A, ARG128B, ARG141A, ARG149A, ARG159A, ARG162A, ARG166B, ARG167A, ARG169B, ARG171A, ARG176B, ARG194B, ARG197A, ARG199A, ARG255B, ARG264B, ARG415B, ARG50A, ARG65A, ARG94B, ARG95A, ASN101B, ASN102A, ASN103B, ASN135B, ASN139A, ASN140B, ASN160B, ASN164B, ASN174B, ASN275B, ASN59A, ASN67A, ASN71A, ASN79A, ASN80A, ASN95B, ASP105A, ASP146A, ASP153A, ASP154B, ASP155A, ASP174A, ASP177A, ASP180A, ASP185B, ASP192A, ASP198A, ASP257B, ASP261B, ASP425B, ASP433B, ASP56A, ASP61B, ASP97A, ASP98B, CYS161A, CYS165A, CYS193B, CYS197B, CYS28A, CYS49A, CYS65B, CYS76B, CYS80B, GLN126B, GLN129B, GLN131A, GLN131B, GLN134A, GLN137A, GLN143A, GLN150B, GLN180B, GLN181A, GLN182A, GLN184A, GLN187A, GLN189B, GLN200A, GLN256B, GLN421B, GLN60A, GLN77A, GLN81B, GLN83B, GLN88B, GLN89B, GLU105B, GLU113A, GLU120A, GLU128A, GLU136B, GLU141B, GLU145B, GLU147B, GLU151A, GLU155B, GLU172A, GLU173B, GLU179A, GLU183B, GLU186A, GLU191B, GLU291B, GLU57A, GLU84B, GLU90B, GLU99B, GLY163A, GLY258B, GLY263B, GLY274B, GLY290B, GLY414B, GLY419B, GLY420B, GLY430B, GLY434B, GLY48A, GLY53A, GLY63B, GLY64B, GLY79B, GLY96A, HIS132A, HIS149B, HIS429B, HIS84A, ILE119A, ILE127A, ILE133A, ILE153B, ILE154A, ILE156A, ILE158A, ILE161B, ILE171B, ILE179B, ILE189A, ILE55A, ILE66A, ILE90A, ILE93A, ILE93B, LEU100B, LEU115A, LEU120B, LEU121B, LEU122A, LEU124B, LEU135A, LEU136A, LEU144A, LEU146B, LEU150A, LEU151B, LEU165B, LEU168B, LEU169A, LEU172B, LEU175A, LEU175B, LEU182B, LEU185A, LEU193A, LEU194A, LEU54A, LEU69A, LEU73A, LEU75B, LEU82B, LEU86B, LEU87B, LEU94A, LYS123A, LYS127B, LYS129A, LYS130B, LYS133B, LYS138A, LYS148A, LYS148B, LYS157A, LYS176A, LYS178B, LYS181B, LYS183A, LYS191A, LYS29A, LYS428B, LYS52A, LYS58B, LYS70A, MET118B, MET147A, MET190B, MET426B, MET51A, MET91A, PHE115B, PHE262B, PHE62A, PHE74A, PHE98A, PRO195A, PRO196B, PRO46A, PRO60B, PRO77B, PRO92B, SER100A, SER108B, SER111B, SER112A, SER112B, SER113B, SER114B, SER143B, SER144B, SER160A, SER164A, SER166A, SER170B, SER177B, SER184B, SER187B, SER196A, SER259B, SER446B, SER47A, SER72A, SER83A, SER96B, SER99A, THR110B, THR156B, THR163B, THR195B, THR198B, THR278B, THR423B, THR431B, THR63A, THR78B, THR87A, TRP125B, TRP317B, TRP418B, TRP424B, TRP444B, TYR108A, TYR117B, TYR142B, TYR152B, TYR178A, TYR192B, TYR416B, TYR417B, TYR422B, TYR76A, VAL104B, VAL107B, VAL126A, VAL130A, VAL132B, VAL139B, VAL140A, VAL145A, VAL152A, VAL157B, VAL167B, VAL173A, VAL186B, VAL188A, VAL199B, VAL260B, VAL58A, VAL74B, VAL97B
• A-C: ALA101A, ALA129C, ALA133C, ALA142A, ALA168A, ALA26C, ALA81C, ALA82C, ALA98C, ARG104A, ARG108C, ARG110A, ARG116A, ARG118A, ARG141A, ARG149A, ARG159A, ARG162A, ARG171A, ARG50A, ARG65A, ARG87C, ASN102A, ASN103A, ASN106A, ASN109A, ASN115C, ASN117C, ASN118C, ASN123C, ASN139A, ASN42A, ASN52C, ASN59A, ASN67A, ASN71A, ASN79A, ASN80A, ASN89A, ASP104C, ASP105A, ASP114A, ASP146A, ASP153A, ASP155A, ASP27C, ASP37C, ASP39C, ASP40A, ASP45C, ASP56A, ASP61A, ASP71C, ASP80C, ASP82A, ASP97A, CYS135C, CYS139C, CYS161A, CYS165A, CYS23C, CYS45A, CYS49A, GLN111C, GLN119C, GLN134C, GLN136C, GLN137A, GLN143A, GLN33C, GLN41C, GLN65C, GLU112C, GLU113A, GLU120A, GLU126C, GLU128A, GLU132C, GLU137C, GLU151A, GLU44C, GLU51C, GLU57A, GLU75A, GLU91C, GLU92C, GLU97C, GLY163A, GLY24C, GLY48A, GLY53A, HIS103C, HIS132A, HIS48C, HIS84A, ILE100C, ILE107C, ILE113C, ILE119A, ILE121C, ILE127A, ILE133A, ILE154A, ILE156A, ILE158A, ILE25C, ILE46C, ILE55A, ILE61C, ILE64C, ILE66A, ILE79C, ILE90A, ILE93A, ILE93C, LEU101C, LEU110C, LEU115A, LEU122A, LEU124C, LEU131C, LEU135A, LEU136A, LEU144A, LEU150A, LEU169A, LEU29C, LEU40C, LEU43C, LEU47C, LEU54A, LEU60C, LEU69A, LEU73A, LEU84C, LEU86A, LEU90C, LEU94A, LYS120C, LYS123A, LYS125A, LYS125C, LYS127C, LYS129A, LYS138A, LYS140C, LYS148A, LYS157A, LYS35C, LYS38C, LYS44A, LYS52A, LYS58C, LYS62C, LYS68A, LYS70A, LYS75C, LYS85C, LYS88C, MET147A, MET51A, MET78C, MET89C, MET94C, PHE28C, PHE62A, PHE74A, PHE98A, PRO138C, PRO46A, PRO70C, SER100A, SER105C, SER106C, SER112A, SER116C, SER117A, SER160A, SER164A, SER166A, SER30C, SER42C, SER47A, SER55C, SER72A, SER74C, SER83A, SER86C, SER99C, THR107A, THR21C, THR22C, THR31C, THR34C, THR54C, THR63A, THR83C, THR87A, TRP41A, TYR108A, TYR114C, TYR178A, TYR32C, TYR43A, TYR68C, TYR76A, TYR96C, VAL111A, VAL121A, VAL122C, VAL126A, VAL128C, VAL130A, VAL140A, VAL145A, VAL36C, VAL50C, VAL57C, VAL58A
• A-D: ALA27A, ALA27D, ARG50A, ARG50D, ASP30A, ASP30D, CYS28A, CYS28D, CYS45A, CYS45D, CYS49A, CYS49D, GLY48A, GLY48D, GLY53A, GLY53D, LYS29A, LYS29D, LYS44A, LYS44D, LYS52A, LYS52D, PRO46A, PRO46D, SER47A, SER47D, TRP33A, TRP33D, TYR43D
• A-E: ALA27A, ALA59E, ALA62E, ALA68E, ALA85E, ARG50A, ASN42A, ASP30A, ASP32A, ASP38A, ASP40A, ASP61E, ASP69E, ASP71E, CYS28A, CYS36A, CYS45A, CYS65E, CYS76E, CYS80E, GLN81E, GLU57A, GLY48A, GLY63E, GLY64E, GLY73E, GLY79E, HIS67E, LEU54A, LEU66E, LEU72E, LEU75E, LEU82E, LYS29A, LYS44A, LYS58E, MET51A, PHE35A, PRO34A, PRO46A, PRO60E, PRO70E, PRO77E, SER31A, SER37A, SER47A, THR78E, TRP33A, TRP41A, TYR43A, VAL74E
• A-F: ASN42A, CYS19F, CYS45A, GLY16F, SER17F, TYR43A
• B-C: ALA129C, ALA133C, ALA188B, ALA26C, ALA277B, ALA63C, ALA81C, ALA82C, ALA85B, ALA98C, ARG108C, ARG166B, ARG169B, ARG176B, ARG194B, ARG216B, ARG237B, ARG264B, ARG415B, ARG91B, ARG94B, ASN101B, ASN102B, ASN103B, ASN115C, ASN117C, ASN118C, ASN123C, ASN135B, ASN137B, ASN140B, ASN158B, ASN160B, ASN164B, ASN174B, ASN175C, ASN202B, ASN207C, ASN275B, ASN279B, ASN284B, ASN69C, ASN77C, ASP104C, ASP141C, ASP147C, ASP154B, ASP185B, ASP199C, ASP230B, ASP261B, ASP39C, ASP45C, ASP80C, ASP98B, CYS135C, CYS139C, CYS193B, CYS197B, CYS19C, CYS201B, CYS286B, CYS76B, CYS80B, GLN109B, GLN111C, GLN116B, GLN119C, GLN126B, GLN129B, GLN130C, GLN134C, GLN136C, GLN144C, GLN150B, GLN176C, GLN177C, GLN180B, GLN189B, GLN195C, GLN210C, GLN228B, GLN33C, GLN49C, GLN59C, GLN65C, GLN81B, GLN83B, GLN89B, GLU105B, GLU112C, GLU126C, GLU132C, GLU136B, GLU137C, GLU141B, GLU147B, GLU155B, GLU173B, GLU183B, GLU191B, GLU210B, GLU213B, GLU213C, GLU220B, GLU223B, GLU225C, GLU231C, GLU291B, GLU44C, GLU51C, GLU56C, GLU84B, GLU90B, GLU92C, GLU97C, GLU99B, GLY208B, GLY214C, GLY216C, GLY218B, GLY219B, GLY222C, GLY229C, GLY24C, GLY263B, GLY272B, GLY274B, GLY287B, GLY79B, HIS103C, HIS146C, HIS217C, ILE100C, ILE107C, ILE113C, ILE121C, ILE145C, ILE153B, ILE161B, ILE171B, ILE179B, ILE203B, ILE209C, ILE214B, ILE215B, ILE227B, ILE25C, ILE46C, ILE61C, ILE64C, ILE79C, ILE93B, ILE93C, LEU100B, LEU110C, LEU121B, LEU124C, LEU131C, LEU146B, LEU151B, LEU165B, LEU166C, LEU168B, LEU172B, LEU175B, LEU179C, LEU182B, LEU198C, LEU218C, LEU226B, LEU228C, LEU29C, LEU40C, LEU43C, LEU47C, LEU60C, LEU82B, LEU86B, LEU87B, LEU90C, LYS120C, LYS122B, LYS125C, LYS127C, LYS130B, LYS133B, LYS140C, LYS148B, LYS170C, LYS178B, LYS181B, LYS206C, LYS209B, LYS212C, LYS217B, LYS232C, LYS234B, LYS265B, LYS283B, LYS35C, LYS38C, LYS428B, LYS53C, LYS58C, LYS75C, LYS85C, LYS88C, LYS95C, MET118B, MET190B, MET224B, MET78C, MET89C, PHE115B, PHE168C, PHE178C, PHE194C, PHE215C, PHE226C, PHE262B, PHE273B, PHE28C, PRO138C, PRO162B, PRO196B, PRO204B, PRO20C, PRO220C, PRO229B, PRO235B, PRO268B, PRO76C, PRO77B, PRO92B, SER105C, SER106C, SER108B, SER111B, SER112B, SER113B, SER114B, SER116C, SER143B, SER144B, SER159B, SER170B, SER177B, SER17C, SER184B, SER187B, SER200B, SER201C, SER207B, SER219C, SER231B, SER232B, SER259B, SER42C, SER55C, SER86C, SER96B, SER99C, THR102C, THR142C, THR156B, THR163B, THR195B, THR198B, THR21C, THR221B, THR221C, THR223C, THR224C, THR22C, THR278B, THR31C, THR54C, THR67C, THR78B, TRP125B, TRP227C, TYR109C, TYR114C, TYR117B, TYR119B, TYR181C, TYR18C, TYR192B, TYR211C, TYR225B, TYR236B, TYR285B, TYR292B, TYR32C, TYR378B, TYR68C, TYR96C, VAL104B, VAL122C, VAL128C, VAL132B, VAL143C, VAL157B, VAL167B, VAL180C, VAL186B, VAL199B, VAL202C, VAL205B, VAL206B, VAL233B, VAL260B, VAL276B, VAL36C, VAL50C, VAL57C, VAL97B
• B-D: ALA27D, ALA59B, ALA62B, ALA68B, ARG50D, ASN42D, ASP30D, ASP32D, ASP38D, ASP40D, ASP61B, ASP69B, ASP71B, CYS28D, CYS36D, CYS45D, CYS65B, CYS76B, CYS80B, GLN81B, GLU57D, GLY48D, GLY63B, GLY64B, GLY73B, GLY79B, HIS67B, LEU54D, LEU66B, LEU72B, LEU75B, LEU82B, LYS29D, LYS44D, LYS58B, MET51D, PHE35D, PRO34D, PRO46D, PRO60B, PRO70B, PRO77B, SER31D, SER37D, SER47D, THR78B, TRP33D, TRP41D, TYR43D, VAL74B
• B-E: ALA59B, ALA59E, ASP61B, ASP61E, ASP69E, ASP71B, ASP71E, GLY73B, GLY73E, LEU72B, LEU72E, LYS58B, LYS58E, PRO60B, PRO60E, PRO70B, PRO70E, VAL74B
• B-F: ALA26F, ARG14F, ARG91B, ARG94B, ASP71B, CYS19F, CYS23F, CYS76B, CYS80B, GLN33F, GLN81B, GLN83B, GLU84B, GLU90B, GLY24F, GLY79B, LEU29F, LEU72B, LEU75B, LEU82B, LEU86B, LEU87B, PHE15F, PRO20F, PRO77B, SER30F, THR21F, THR22F, THR78B, TYR18F
• B-O: ALA357B, ALA409B, ALA410B, ARG365B, ARG391B, ARG3O, ARG406B, ASN364B, ASN405B, ASN411B, ASP383B, ASP398B, ASP432B, ASP433B, CYS394B, CYS407B, GLN359B, GLN393B, GLU363B, GLU397B, GLY1O, GLY399B, GLY430B, GLY442B, HIS2O, HIS370B, HIS408B, HIS429B, ILE369B, LEU360B, LYS392B, LYS396B, MET361B, MET367B, MET438B, PRO4O, SER395B, SER443B, THR366B, THR368B, THR431B, TRP385B, TYR404B, TYR422B, VAL436B
• C-D: ASN42D, CYS19C, CYS45D, GLY16C, GLY48D, ILE55D, MET51D, PHE15C, SER17C, SER47D, THR22C, TRP41D, TYR43D
• C-E: ALA26C, ARG14C, ARG91E, ARG94E, ASP27C, ASP69E, ASP71E, CYS19C, CYS23C, CYS76E, CYS80E, GLN83E, GLN88E, GLU84E, GLU90E, GLY24C, GLY79E, ILE25C, LEU29C, LEU72E, LEU75E, LEU82E, LEU86E, LEU87E, PHE15C, PRO20C, PRO77E, SER30C, THR21C, THR22C, THR78E, TYR18C
• C-F: ALA26C, ALA26F, ARG14C, ARG14F, ASP27C, ASP27F, CYS19C, CYS19F, CYS23C, CYS23F, GLY16C, GLY16F, GLY24C, GLY24F, ILE25C, ILE25F, LEU29C, LEU29F, LYS35F, PHE15C, PHE15F, PHE28C, PHE28F, PRO20C, PRO20F, SER17C, SER17F, THR21C, THR21F, THR22C, THR22F, THR31C, TYR18C, TYR18F, TYR32C, TYR32F
• C-M: ALA341C, ALA370C, ARG375C, ARG3M, ASN325C, ASN337C, ASN365C, ASP294C, ASP297C, ASP298C, ASP301C, ASP330C, ASP364C, CYS326C, CYS339C, GLN329C, GLU323C, GLY1M, GLY296C, GLY324C, GLY342C, GLY366C, HIS307C, HIS340C, HIS343C, ILE368C, LYS302C, LYS321C, LYS338C, MET336C, PHE293C, PHE295C, PHE304C, PHE322C, PRO2M, PRO4M, SER300C, THR305C, TRP376C, TYR354C, TYR363C
• D-E: ALA101D, ALA106E, ALA168D, ALA170D, ALA188E, ALA427E, ALA59E, ALA62E, ALA85E, ARG116D, ARG128E, ARG141D, ARG149D, ARG159D, ARG162D, ARG166E, ARG167D, ARG169E, ARG171D, ARG176E, ARG194E, ARG197D, ARG199D, ARG255E, ARG264E, ARG415E, ARG50D, ARG65D, ARG94E, ARG95D, ASN102D, ASN102E, ASN103E, ASN139D, ASN158E, ASN160E, ASN164E, ASN174E, ASN275E, ASN59D, ASN64D, ASN67D, ASN71D, ASN79D, ASN80D, ASN95E, ASP105D, ASP146D, ASP153D, ASP154E, ASP155D, ASP174D, ASP177D, ASP180D, ASP185E, ASP192D, ASP198D, ASP257E, ASP261E, ASP425E, ASP433E, ASP56D, ASP61D, ASP61E, ASP97D, CYS161D, CYS165D, CYS193E, CYS197E, CYS49D, CYS65E, CYS76E, GLN126E, GLN129E, GLN134D, GLN137D, GLN143D, GLN150E, GLN180E, GLN181D, GLN182D, GLN184D, GLN187D, GLN189E, GLN200D, GLN256E, GLN421E, GLN60D, GLN77D, GLN81E, GLN83E, GLN88E, GLN89E, GLU105E, GLU141E, GLU145E, GLU147E, GLU151D, GLU155E, GLU172D, GLU173E, GLU179D, GLU183E, GLU186D, GLU191E, GLU291E, GLU57D, GLU84E, GLU90E, GLU99E, GLY163D, GLY258E, GLY263E, GLY274E, GLY290E, GLY399E, GLY414E, GLY419E, GLY430E, GLY434E, GLY48D, GLY53D, GLY63E, GLY64E, GLY79E, HIS132D, HIS149E, HIS429E, HIS84D, ILE119D, ILE127D, ILE133D, ILE153E, ILE154D, ILE156D, ILE158D, ILE161E, ILE171E, ILE179E, ILE189D, ILE55D, ILE66D, ILE90D, ILE93D, ILE93E, LEU100E, LEU115D, LEU121E, LEU122D, LEU124E, LEU136D, LEU144D, LEU146E, LEU150D, LEU165E, LEU168E, LEU169D, LEU172E, LEU175D, LEU175E, LEU182E, LEU185D, LEU193D, LEU194D, LEU54D, LEU69D, LEU73D, LEU75E, LEU82E, LEU86D, LEU86E, LEU87E, LEU94D, LYS122E, LYS123D, LYS129D, LYS138D, LYS148D, LYS148E, LYS157D, LYS176D, LYS178E, LYS181E, LYS183D, LYS191D, LYS29D, LYS428E, LYS52D, LYS58E, LYS68D, LYS70D, MET118E, MET147D, MET190E, MET426E, MET51D, MET91D, PHE115E, PHE262E, PHE62D, PHE74D, PHE98D, PRO195D, PRO196E, PRO46D, PRO60E, PRO77E, PRO92E, SER108E, SER111E, SER112D, SER112E, SER114E, SER143E, SER159E, SER160D, SER164D, SER166D, SER170E, SER177E, SER184E, SER187E, SER196D, SER259E, SER47D, SER72D, SER83D, SER96E, THR110E, THR156E, THR163E, THR195E, THR198E, THR278E, THR423E, THR431E, THR63D, THR78E, THR87D, TRP125E, TRP317E, TRP418E, TRP424E, TRP444E, TYR117E, TYR142E, TYR152E, TYR178D, TYR192E, TYR416E, TYR417E, TYR422E, TYR76D, VAL104E, VAL107E, VAL126D, VAL130D, VAL132E, VAL139E, VAL140D, VAL145D, VAL152D, VAL157E, VAL167E, VAL173D, VAL186E, VAL188D, VAL260E, VAL58D, VAL74E, VAL97E
• D-F: ALA101D, ALA129F, ALA133F, ALA142D, ALA168D, ALA26F, ALA81F, ALA82F, ALA98F, ARG104D, ARG108F, ARG110D, ARG116D, ARG118D, ARG149D, ARG159D, ARG162D, ARG50D, ARG65D, ARG87F, ASN102D, ASN103D, ASN109D, ASN115F, ASN117F, ASN118F, ASN139D, ASN42D, ASN59D, ASN69F, ASN71D, ASN77F, ASN79D, ASN80D, ASN89D, ASP104F, ASP105D, ASP114D, ASP146D, ASP153D, ASP27F, ASP37F, ASP39F, ASP40D, ASP45F, ASP56D, ASP61D, ASP80F, ASP82D, ASP97D, CYS135F, CYS139F, CYS161D, CYS165D, CYS23F, CYS45D, CYS49D, GLN111F, GLN119F, GLN130F, GLN134F, GLN136F, GLN143D, GLN33F, GLN41F, GLN60D, GLN65F, GLU112F, GLU113D, GLU126F, GLU132F, GLU137F, GLU151D, GLU44F, GLU51F, GLU57D, GLU72F, GLU75D, GLU91F, GLU92F, GLU97F, GLY163D, GLY24F, GLY48D, GLY53D, GLY96D, HIS103F, HIS132D, HIS48F, HIS84D, ILE100F, ILE107F, ILE113F, ILE119D, ILE121F, ILE133D, ILE154D, ILE156D, ILE158D, ILE25F, ILE46F, ILE55D, ILE61F, ILE64F, ILE66D, ILE79F, ILE90D, ILE93D, ILE93F, LEU101F, LEU110F, LEU115D, LEU122D, LEU124F, LEU131F, LEU135D, LEU136D, LEU144D, LEU150D, LEU29F, LEU40F, LEU43F, LEU47F, LEU54D, LEU60F, LEU69D, LEU73D, LEU84F, LEU86D, LEU90F, LEU94D, LYS120F, LYS123D, LYS125D, LYS125F, LYS127F, LYS129D, LYS138D, LYS140F, LYS157D, LYS35F, LYS38F, LYS44D, LYS52D, LYS53F, LYS58F, LYS62F, LYS68D, LYS70D, LYS85F, LYS88F, LYS95F, MET147D, MET51D, MET78F, MET89F, MET94F, PHE28F, PHE62D, PHE98D, PRO138F, PRO46D, PRO70F, PRO76F, SER100D, SER112D, SER116F, SER160D, SER164D, SER166D, SER30F, SER42F, SER47D, SER55F, SER72D, SER73F, SER83D, SER85D, SER86F, SER99D, THR107D, THR21F, THR22F, THR31F, THR34F, THR54F, THR63D, THR83F, THR87D, TRP41D, TYR108D, TYR109F, TYR114F, TYR32F, TYR43D, TYR68F, TYR76D, TYR96F, VAL111D, VAL122F, VAL126D, VAL128F, VAL130D, VAL140D, VAL36F, VAL50F, VAL57F, VAL58D
• E-F: ALA129F, ALA133F, ALA188E, ALA26F, ALA277E, ALA63F, ALA82F, ALA85E, ARG108F, ARG128E, ARG166E, ARG169E, ARG176E, ARG194E, ARG216E, ARG237E, ARG264E, ARG415E, ARG91E, ARG94E, ASN101E, ASN102E, ASN115F, ASN117F, ASN118F, ASN123F, ASN135E, ASN137E, ASN140E, ASN158E, ASN160E, ASN164E, ASN174E, ASN175F, ASN202E, ASN207F, ASN275E, ASN279E, ASN284E, ASN77F, ASP104F, ASP134E, ASP141F, ASP147F, ASP154E, ASP185E, ASP199F, ASP230E, ASP261E, ASP27F, ASP37F, ASP39F, ASP80F, ASP98E, CYS135F, CYS139F, CYS193E, CYS197E, CYS19F, CYS201E, CYS23F, CYS286E, CYS76E, CYS80E, GLN111F, GLN116E, GLN119F, GLN126E, GLN129E, GLN130F, GLN131E, GLN134F, GLN136F, GLN144F, GLN150E, GLN176F, GLN177F, GLN180E, GLN189E, GLN195F, GLN210F, GLN228E, GLN81E, GLN83E, GLN89E, GLU105E, GLU112F, GLU126F, GLU132F, GLU136E, GLU137F, GLU147E, GLU155E, GLU173E, GLU183E, GLU191E, GLU210E, GLU213E, GLU213F, GLU220E, GLU223E, GLU225F, GLU231F, GLU291E, GLU44F, GLU51F, GLU56F, GLU72F, GLU84E, GLU90E, GLU92F, GLU97F, GLU99E, GLY208E, GLY214F, GLY216F, GLY218E, GLY219E, GLY222F, GLY229F, GLY24F, GLY258E, GLY263E, GLY272E, GLY274E, GLY287E, GLY79E, HIS103F, HIS217F, ILE100F, ILE107F, ILE113F, ILE121F, ILE145F, ILE153E, ILE161E, ILE171E, ILE179E, ILE203E, ILE209F, ILE214E, ILE215E, ILE227E, ILE25F, ILE46F, ILE61F, ILE64F, ILE79F, ILE93E, ILE93F, LEU100E, LEU110F, LEU124F, LEU131F, LEU146E, LEU151E, LEU165E, LEU166F, LEU168E, LEU172E, LEU175E, LEU179F, LEU182E, LEU198F, LEU218F, LEU226E, LEU228F, LEU29F, LEU40F, LEU43F, LEU47F, LEU60F, LEU82E, LEU84F, LEU86E, LEU87E, LEU90F, LYS120F, LYS122E, LYS125F, LYS127F, LYS130E, LYS133E, LYS140F, LYS170F, LYS178E, LYS181E, LYS206F, LYS209E, LYS212F, LYS217E, LYS232F, LYS234E, LYS265E, LYS283E, LYS35F, LYS428E, LYS53F, LYS58F, LYS75F, LYS85F, LYS88F, MET118E, MET190E, MET224E, MET78F, MET89F, PHE115E, PHE168F, PHE178F, PHE194F, PHE215F, PHE226F, PHE262E, PHE273E, PHE28F, PRO138F, PRO162E, PRO196E, PRO204E, PRO20F, PRO220F, PRO229E, PRO235E, PRO268E, PRO77E, PRO92E, SER105F, SER106F, SER108E, SER111E, SER112E, SER114E, SER116F, SER143E, SER144E, SER159E, SER170E, SER177E, SER17F, SER184E, SER187E, SER200E, SER201F, SER207E, SER219F, SER231E, SER259E, SER30F, SER42F, SER55F, SER86F, SER96E, SER99F, THR102F, THR142F, THR156E, THR195E, THR198E, THR21F, THR221E, THR221F, THR223F, THR224F, THR22F, THR278E, THR54F, THR67F, THR78E, THR83F, TRP125E, TRP227F, TYR109F, TYR114F, TYR117E, TYR119E, TYR142E, TYR181F, TYR18F, TYR192E, TYR211F, TYR225E, TYR236E, TYR285E, TYR292E, TYR32F, TYR378E, TYR68F, TYR96F, VAL104E, VAL107E, VAL122F, VAL128F, VAL132E, VAL139E, VAL143F, VAL157E, VAL167E, VAL180F, VAL186E, VAL199E, VAL202F, VAL205E, VAL206E, VAL233E, VAL260E, VAL276E, VAL36F, VAL50F, VAL57F, VAL97E
• E-P: ALA357E, ALA409E, ALA410E, ARG365E, ARG391E, ARG3P, ARG406E, ASN364E, ASN405E, ASN411E, ASP383E, ASP398E, ASP432E, ASP433E, CYS394E, CYS407E, GLN359E, GLN393E, GLU363E, GLU397E, GLY1P, GLY384E, GLY399E, GLY430E, HIS2P, HIS370E, HIS408E, HIS429E, LEU360E, LYS392E, LYS396E, MET361E, MET367E, MET438E, PRO4P, SER395E, SER443E, THR366E, THR368E, THR387E, THR431E, TRP385E, TRP444E, TYR404E, VAL436E
• F-K: ARG194K, GLU323F
• F-N: ALA327F, ALA341F, ALA370F, ARG375F, ARG3N, ASN325F, ASN337F, ASN361F, ASN365F, ASP294F, ASP297F, ASP298F, ASP301F, ASP330F, ASP364F, CYS326F, CYS339F, GLN329F, GLU323F, GLU328F, GLY1N, GLY296F, GLY324F, GLY342F, GLY362F, GLY366F, HIS307F, HIS340F, HIS343F, ILE368F, LYS302F, LYS338F, LYS356F, MET336F, PHE293F, PHE295F, PHE303F, PHE304F, PHE322F, PRO2N, PRO360F, PRO4N, SER300F, THR305F, THR359F, TYR354F, TYR363F
• G-H: ALA101G, ALA168G, ALA170G, ALA188H, ALA427H, ALA59H, ALA62H, ALA85H, ARG116G, ARG124G, ARG128H, ARG141G, ARG149G, ARG159G, ARG162G, ARG166H, ARG167G, ARG169H, ARG171G, ARG176H, ARG194H, ARG197G, ARG199G, ARG255H, ARG264H, ARG415H, ARG50G, ARG65G, ARG94H, ASN101H, ASN102G, ASN102H, ASN103H, ASN109G, ASN139G, ASN160H, ASN164H, ASN174H, ASN275H, ASN59G, ASN64G, ASN67G, ASN71G, ASN79G, ASN80G, ASN95H, ASP105G, ASP114G, ASP146G, ASP153G, ASP154H, ASP155G, ASP174G, ASP177G, ASP180G, ASP185H, ASP192G, ASP198G, ASP257H, ASP261H, ASP425H, ASP433H, ASP56G, ASP61G, ASP61H, ASP82G, ASP97G, ASP98H, CYS161G, CYS165G, CYS193H, CYS197H, CYS49G, CYS65H, CYS76H, GLN109H, GLN129H, GLN131G, GLN131H, GLN134G, GLN137G, GLN143G, GLN150H, GLN180H, GLN181G, GLN182G, GLN184G, GLN187G, GLN189H, GLN200G, GLN256H, GLN421H, GLN60G, GLN77G, GLN81H, GLN83H, GLN88H, GLN89H, GLU105H, GLU113G, GLU120G, GLU145H, GLU151G, GLU155H, GLU172G, GLU173H, GLU179G, GLU183H, GLU186G, GLU191H, GLU291H, GLU57G, GLU75G, GLU84H, GLU90H, GLU99H, GLY163G, GLY258H, GLY263H, GLY274H, GLY290H, GLY414H, GLY419H, GLY430H, GLY434H, GLY48G, GLY53G, GLY63H, GLY64H, GLY79H, HIS132G, HIS149H, HIS429H, HIS84G, ILE119G, ILE127G, ILE133G, ILE153H, ILE154G, ILE156G, ILE158G, ILE161H, ILE171H, ILE179H, ILE189G, ILE55G, ILE66G, ILE90G, ILE93H, LEU100H, LEU115G, LEU121H, LEU122G, LEU124H, LEU135G, LEU136G, LEU144G, LEU146H, LEU150G, LEU151H, LEU165H, LEU168H, LEU169G, LEU172H, LEU175G, LEU175H, LEU182H, LEU185G, LEU193G, LEU194G, LEU54G, LEU69G, LEU73G, LEU75H, LEU82H, LEU86H, LEU87H, LEU94G, LYS122H, LYS123G, LYS129G, LYS138G, LYS148G, LYS148H, LYS157G, LYS176G, LYS178H, LYS181H, LYS183G, LYS191G, LYS428H, LYS52G, LYS58H, LYS68G, LYS70G, LYS81G, MET118H, MET147G, MET190H, MET426H, MET51G, MET91G, PHE115H, PHE262H, PHE62G, PHE74G, PHE98G, PRO162H, PRO195G, PRO196H, PRO46G, PRO60H, PRO77H, PRO92H, SER108H, SER111H, SER112G, SER112H, SER113H, SER114H, SER117G, SER143H, SER144H, SER159H, SER160G, SER164G, SER166G, SER170H, SER177H, SER184H, SER187H, SER196G, SER259H, SER446H, SER47G, SER83G, SER96H, THR110H, THR156H, THR163H, THR195H, THR198H, THR278H, THR423H, THR431H, THR63G, THR78H, THR87G, TRP125H, TRP317H, TRP418H, TRP424H, TRP444H, TYR108G, TYR117H, TYR142H, TYR152H, TYR178G, TYR192H, TYR416H, TYR417H, TYR422H, TYR76G, VAL104H, VAL107H, VAL126G, VAL130G, VAL132H, VAL139H, VAL140G, VAL145G, VAL152G, VAL157H, VAL167H, VAL173G, VAL186H, VAL188G, VAL199H, VAL260H, VAL435H, VAL58G, VAL74H, VAL97H
• G-I: ALA101G, ALA129I, ALA133I, ALA142G, ALA168G, ALA26I, ALA81I, ALA82I, ALA98I, ARG104G, ARG108I, ARG116G, ARG118G, ARG141G, ARG149G, ARG159G, ARG162G, ARG171G, ARG50G, ARG65G, ARG87I, ASN102G, ASN103G, ASN106G, ASN109G, ASN115I, ASN117I, ASN118I, ASN123I, ASN139G, ASN42G, ASN52I, ASN59G, ASN64G, ASN67G, ASN77I, ASN79G, ASN80G, ASP104I, ASP105G, ASP114G, ASP146G, ASP153G, ASP155G, ASP27I, ASP37I, ASP39I, ASP40G, ASP45I, ASP56G, ASP61G, ASP80I, ASP97G, CYS135I, CYS139I, CYS161G, CYS165G, CYS23I, CYS45G, CYS49G, GLN111I, GLN119I, GLN130I, GLN131G, GLN134G, GLN134I, GLN136I, GLN143G, GLN33I, GLN41I, GLN65I, GLU112I, GLU113G, GLU120G, GLU126I, GLU128G, GLU132I, GLU137I, GLU151G, GLU44I, GLU51I, GLU57G, GLU75G, GLU91I, GLU92I, GLU97I, GLY163G, GLY24I, GLY48G, GLY53G, HIS103I, HIS132G, HIS48I, ILE100I, ILE107I, ILE113I, ILE119G, ILE121I, ILE127G, ILE133G, ILE154G, ILE156G, ILE158G, ILE25I, ILE46I, ILE55G, ILE61I, ILE64I, ILE66G, ILE79I, ILE90G, ILE93G, ILE93I, LEU101I, LEU110I, LEU115G, LEU122G, LEU124I, LEU131I, LEU135G, LEU136G, LEU144G, LEU150G, LEU169G, LEU29I, LEU40I, LEU43I, LEU47I, LEU54G, LEU69G, LEU73G, LEU84I, LEU86G, LEU90I, LEU94G, LYS120I, LYS123G, LYS125G, LYS125I, LYS127I, LYS129G, LYS138G, LYS140I, LYS148G, LYS157G, LYS35I, LYS38I, LYS44G, LYS52G, LYS53I, LYS58I, LYS68G, LYS70G, LYS85I, LYS88I, MET147G, MET51G, MET78I, MET89I, MET94I, PHE28I, PHE62G, PHE74G, PRO138I, PRO46G, SER100G, SER105I, SER106I, SER112G, SER116I, SER160G, SER164G, SER30I, SER42I, SER47G, SER55I, SER72G, SER83G, SER86I, SER99I, THR107G, THR21I, THR22I, THR31I, THR34I, THR54I, THR63G, THR83I, THR87G, TRP41G, TYR108G, TYR114I, TYR178G, TYR32I, TYR43G, TYR68I, TYR76G, TYR96I, VAL111G, VAL122I, VAL126G, VAL128I, VAL130G, VAL140G, VAL145G, VAL36I, VAL50I, VAL57I, VAL58G
• G-J: ALA27G, ALA27J, ARG50G, ARG50J, ASP30G, ASP30J, ASP32G, CYS28G, CYS28J, CYS45G, CYS45J, CYS49G, CYS49J, GLY48G, GLY48J, GLY53J, LYS29G, LYS29J, LYS44G, LYS44J, LYS52G, LYS52J, PRO46G, PRO46J, SER47G, SER47J, TRP33G, TRP33J, TYR43J
• G-K: ALA27G, ALA62K, ALA68K, ARG50G, ASN42G, ASP30G, ASP32G, ASP38G, ASP40G, ASP61K, ASP69K, ASP71K, CYS28G, CYS36G, CYS45G, CYS65K, CYS76K, CYS80K, GLN81K, GLU57G, GLY63K, GLY64K, GLY73K, GLY79K, HIS67K, LEU54G, LEU66K, LEU72K, LEU75K, LEU82K, LYS29G, LYS44G, LYS58K, MET51G, PHE35G, PRO34G, PRO46G, PRO70K, PRO77K, SER31G, SER37G, SER47G, THR78K, TRP33G, TRP41G, TYR43G, VAL74K
• G-L: ARG5L, ASN42G, ASN7L, ASP6L, CYS19L, CYS45G, GLY48G, ILE55G, PHE15L, SER17L, THR22L, TRP41G, TYR43G
• H-I: ALA129I, ALA133I, ALA188H, ALA26I, ALA277H, ALA63I, ALA81I, ALA82I, ALA85H, ALA98I, ARG108I, ARG166H, ARG169H, ARG176H, ARG194H, ARG216H, ARG237H, ARG264H, ARG415H, ARG87I, ARG91H, ARG94H, ASN101H, ASN102H, ASN103H, ASN115I, ASN117I, ASN118I, ASN123I, ASN135H, ASN137H, ASN140H, ASN158H, ASN160H, ASN164H, ASN174H, ASN175I, ASN202H, ASN207I, ASN275H, ASN279H, ASN284H, ASN52I, ASN77I, ASP104I, ASP123H, ASP141I, ASP147I, ASP154H, ASP185H, ASP199I, ASP230H, ASP261H, ASP37I, ASP39I, ASP71I, ASP98H, CYS135I, CYS139I, CYS193H, CYS197H, CYS19I, CYS201H, CYS286H, CYS76H, CYS80H, GLN109H, GLN111I, GLN116H, GLN119I, GLN126H, GLN129H, GLN130I, GLN134I, GLN136I, GLN144I, GLN150H, GLN176I, GLN177I, GLN180H, GLN189H, GLN195I, GLN210I, GLN228H, GLN33I, GLN49I, GLN59I, GLN65I, GLN81H, GLN83H, GLN89H, GLU105H, GLU112I, GLU126I, GLU132I, GLU136H, GLU137I, GLU141H, GLU145H, GLU147H, GLU155H, GLU173H, GLU183H, GLU191H, GLU213H, GLU213I, GLU220H, GLU223H, GLU225I, GLU291H, GLU44I, GLU51I, GLU56I, GLU84H, GLU90H, GLU91I, GLU92I, GLU97I, GLU99H, GLY208H, GLY214I, GLY216I, GLY218H, GLY219H, GLY222I, GLY229I, GLY24I, GLY263H, GLY272H, GLY274H, GLY287H, GLY79H, HIS103I, HIS149H, HIS217I, HIS48I, ILE100I, ILE107I, ILE113I, ILE121I, ILE145I, ILE153H, ILE161H, ILE171H, ILE179H, ILE203H, ILE209I, ILE214H, ILE215H, ILE227H, ILE25I, ILE46I, ILE61I, ILE64I, ILE79I, ILE93H, ILE93I, LEU100H, LEU101I, LEU110I, LEU124I, LEU131I, LEU146H, LEU151H, LEU165H, LEU166I, LEU168H, LEU172H, LEU175H, LEU179I, LEU182H, LEU218I, LEU226H, LEU228I, LEU29I, LEU40I, LEU43I, LEU47I, LEU60I, LEU82H, LEU86H, LEU87H, LEU90I, LYS120I, LYS122H, LYS125I, LYS127I, LYS133H, LYS140I, LYS170I, LYS178H, LYS181H, LYS206I, LYS209H, LYS212I, LYS217H, LYS232I, LYS234H, LYS265H, LYS283H, LYS35I, LYS428H, LYS53I, LYS58I, LYS62I, LYS75I, LYS85I, LYS88I, LYS95I, MET118H, MET190H, MET224H, MET78I, MET89I, PHE115H, PHE168I, PHE178I, PHE194I, PHE215I, PHE226I, PHE262H, PHE273H, PHE28I, PRO138I, PRO162H, PRO196H, PRO204H, PRO20I, PRO220I, PRO229H, PRO235H, PRO268H, PRO70I, PRO76I, PRO77H, PRO92H, SER105I, SER106I, SER108H, SER111H, SER112H, SER113H, SER114H, SER116I, SER143H, SER144H, SER159H, SER170H, SER177H, SER17I, SER184H, SER187H, SER200H, SER201I, SER207H, SER219I, SER231H, SER232H, SER259H, SER30I, SER42I, SER55I, SER74I, SER86I, SER96H, SER99I, THR102I, THR110H, THR142I, THR156H, THR163H, THR198H, THR21I, THR221H, THR221I, THR223I, THR224I, THR22I, THR278H, THR54I, THR67I, THR78H, TRP125H, TRP227I, TYR109I, TYR114I, TYR117H, TYR119H, TYR142H, TYR152H, TYR167I, TYR181I, TYR18I, TYR192H, TYR211I, TYR225H, TYR236H, TYR285H, TYR292H, TYR32I, TYR378H, TYR68I, TYR96I, VAL104H, VAL107H, VAL122I, VAL128I, VAL132H, VAL138H, VAL139H, VAL143I, VAL157H, VAL167H, VAL180I, VAL186H, VAL199H, VAL202I, VAL205H, VAL206H, VAL233H, VAL260H, VAL276H, VAL2I, VAL36I, VAL50I, VAL57I, VAL97H
• H-J: ALA62H, ALA68H, ARG50J, ASN42J, ASP30J, ASP32J, ASP38J, ASP40J, ASP61H, ASP69H, ASP71H, CYS28J, CYS36J, CYS45J, CYS65H, CYS76H, CYS80H, GLN81H, GLU39J, GLY48J, GLY63H, GLY64H, GLY73H, GLY79H, HIS67H, LEU54J, LEU66H, LEU72H, LEU75H, LEU82H, LYS29J, LYS44J, LYS58H, MET51J, PHE35J, PRO34J, PRO46J, PRO60H, PRO70H, PRO77H, SER31J, SER37J, SER47J, THR78H, TRP33J, TRP41J, TYR43J, VAL74H
• H-K: ALA59H, ALA59K, ASP61H, ASP71H, ASP71K, LEU72K, LYS58K, PRO60H, PRO60K, PRO70H, PRO70K
• H-L: ALA26L, ARG14L, ARG94H, ASP12L, ASP71H, CYS19L, CYS23L, CYS76H, CYS80H, GLN33L, GLN81H, GLN83H, GLU84H, GLU90H, GLY24L, GLY79H, LEU11L, LEU29L, LEU72H, LEU75H, LEU82H, LEU86H, LEU87H, PHE15L, PRO20L, PRO77H, THR21L, THR22L, THR78H, TYR18L
• H-S: ALA357H, ALA409H, ALA410H, ARG365H, ARG391H, ARG3S, ARG406H, ASN364H, ASN405H, ASN411H, ASP383H, ASP398H, ASP432H, ASP433H, CYS394H, CYS407H, GLN359H, GLN393H, GLU363H, GLU397H, GLY1S, GLY399H, GLY430H, HIS2S, HIS370H, HIS408H, HIS429H, LEU360H, LEU386H, LYS392H, MET361H, MET367H, MET438H, PRO4S, SER395H, SER443H, THR366H, THR368H, THR431H, TRP385H, TRP444H, TYR404H, TYR422H, VAL436H
• I-J: ASN42J, CYS19I, GLY16I, PHE15I, SER17I, TRP41J, TYR43J
• I-K: ALA26I, ASP12I, ASP27I, ASP71K, CYS19I, CYS23I, CYS76K, CYS80K, CYS8I, CYS9I, GLN81K, GLN83K, GLU84K, GLU90K, GLY24I, GLY79K, ILE10I, LEU11I, LEU29I, LEU72K, LEU75K, LEU82K, LEU86K, LEU87K, PHE15I, PRO20I, PRO77K, SER30I, THR21I, THR22I, THR78K, TYR18I
• I-L: ALA26I, ALA26L, ALA3I, ARG14I, ARG14L, ARG5I, ARG5L, ASN7I, ASN7L, ASP12I, ASP12L, ASP27I, ASP27L, ASP6I, ASP6L, CYS19I, CYS19L, CYS23I, CYS23L, CYS8I, CYS8L, CYS9I, CYS9L, GLU13I, GLU13L, GLY16I, GLY16L, GLY24I, GLY24L, ILE10I, ILE10L, ILE25I, ILE25L, LEU11I, LEU11L, LEU29I, LEU29L, LYS35I, LYS35L, PHE15I, PHE15L, PHE28I, PHE28L, PRO20I, PRO20L, SER17I, SER17L, THR21I, THR21L, THR22I, THR22L, THR31I, THR31L, THR4I, TYR18I, TYR18L, TYR32I, TYR32L, VAL2I
• I-Q: ALA327I, ALA341I, ALA370I, ARG375I, ARG3Q, ASN325I, ASN337I, ASN361I, ASN365I, ASP294I, ASP297I, ASP298I, ASP301I, ASP320I, ASP330I, ASP364I, CYS326I, CYS339I, GLN329I, GLU323I, GLU328I, GLY1Q, GLY296I, GLY324I, GLY331I, GLY342I, GLY362I, GLY366I, HIS307I, HIS340I, HIS343I, ILE368I, LYS302I, LYS338I, MET336I, PHE293I, PHE295I, PHE304I, PHE322I, PRO2Q, PRO4Q, SER300I, THR305I, THR359I, TRP376I, TYR354I, TYR363I
• J-K: ALA101J, ALA142J, ALA168J, ALA170J, ALA188K, ALA427K, ALA59K, ALA62K, ALA85K, ARG116J, ARG128K, ARG141J, ARG149J, ARG159J, ARG162J, ARG166K, ARG167J, ARG169K, ARG171J, ARG176K, ARG194K, ARG197J, ARG199J, ARG255K, ARG264K, ARG415K, ARG50J, ARG65J, ARG95J, ASN101K, ASN102J, ASN102K, ASN103K, ASN135K, ASN137K, ASN139J, ASN160K, ASN164K, ASN174K, ASN275K, ASN59J, ASN64J, ASN67J, ASN71J, ASN79J, ASN80J, ASP105J, ASP134K, ASP146J, ASP153J, ASP154K, ASP155J, ASP174J, ASP177J, ASP180J, ASP185K, ASP192J, ASP198J, ASP212J, ASP257K, ASP261K, ASP425K, ASP433K, ASP56J, ASP61J, ASP61K, ASP97J, ASP98K, CYS161J, CYS165J, CYS193K, CYS197K, CYS28J, CYS49J, CYS65K, CYS76K, GLN126K, GLN129K, GLN131K, GLN134J, GLN137J, GLN143J, GLN150K, GLN180K, GLN181J, GLN182J, GLN184J, GLN187J, GLN189K, GLN200J, GLN256K, GLN421K, GLN60J, GLN77J, GLN81K, GLN83K, GLN88K, GLN89K, GLU105K, GLU136K, GLU141K, GLU145K, GLU147K, GLU151J, GLU155K, GLU172J, GLU173K, GLU179J, GLU183K, GLU186J, GLU191K, GLU291K, GLU57J, GLU84K, GLU90K, GLU99K, GLY163J, GLY258K, GLY263K, GLY274K, GLY290K, GLY414K, GLY419K, GLY430K, GLY434K, GLY48J, GLY53J, GLY63K, GLY64K, GLY79K, HIS132J, HIS149K, HIS201J, HIS429K, HIS84J, ILE119J, ILE127J, ILE133J, ILE153K, ILE154J, ILE156J, ILE158J, ILE161K, ILE171K, ILE179K, ILE189J, ILE205J, ILE55J, ILE66J, ILE90J, ILE93K, LEU100K, LEU115J, LEU121K, LEU122J, LEU135J, LEU136J, LEU144J, LEU146K, LEU150J, LEU151K, LEU165K, LEU168K, LEU169J, LEU172K, LEU175J, LEU175K, LEU182K, LEU185J, LEU193J, LEU194J, LEU202J, LEU204J, LEU54J, LEU69J, LEU73J, LEU75K, LEU82K, LEU86K, LEU87K, LEU94J, LYS122K, LYS123J, LYS127K, LYS129J, LYS130K, LYS133K, LYS138J, LYS148J, LYS148K, LYS157J, LYS176J, LYS178K, LYS181K, LYS183J, LYS191J, LYS206J, LYS208J, LYS29J, LYS428K, LYS52J, LYS58K, LYS70J, MET118K, MET147J, MET190K, MET207J, MET426K, MET51J, MET91J, PHE115K, PHE262K, PHE62J, PHE74J, PHE98J, PRO195J, PRO196K, PRO203J, PRO209J, PRO211J, PRO46J, PRO60K, PRO77K, PRO92K, SER108K, SER111K, SER112J, SER112K, SER114K, SER143K, SER144K, SER160J, SER164J, SER166J, SER170K, SER177K, SER184K, SER187K, SER196J, SER259K, SER47J, SER83J, SER96K, THR110K, THR156K, THR163K, THR195K, THR198K, THR278K, THR423K, THR431K, THR63J, THR78K, THR87J, TRP125K, TRP317K, TRP418K, TRP424K, TRP444K, TYR108J, TYR117K, TYR142K, TYR152K, TYR178J, TYR192K, TYR416K, TYR417K, TYR422K, TYR76J, VAL104K, VAL107K, VAL126J, VAL130J, VAL132K, VAL138K, VAL139K, VAL140J, VAL145J, VAL152J, VAL157K, VAL167K, VAL173J, VAL186K, VAL188J, VAL199K, VAL210J, VAL260K, VAL435K, VAL58J, VAL74K, VAL97K
• J-L: ALA101J, ALA129L, ALA133L, ALA142J, ALA168J, ALA26L, ALA81L, ALA82L, ALA98L, ARG104J, ARG108L, ARG110J, ARG116J, ARG118J, ARG141J, ARG149J, ARG159J, ARG162J, ARG167J, ARG50J, ARG65J, ARG87L, ASN109J, ASN115L, ASN117L, ASN118L, ASN139J, ASN42J, ASN52L, ASN59J, ASN69L, ASN79J, ASN80J, ASN89J, ASP104L, ASP105J, ASP114J, ASP146J, ASP153J, ASP27L, ASP37L, ASP39L, ASP40J, ASP45L, ASP56J, ASP61J, ASP71L, ASP80L, ASP82J, ASP97J, CYS135L, CYS139L, CYS161J, CYS165J, CYS23L, CYS45J, CYS49J, GLN111L, GLN119L, GLN130L, GLN131J, GLN134L, GLN136L, GLN143J, GLN33L, GLN41L, GLN65L, GLN77J, GLU112L, GLU126L, GLU128J, GLU132L, GLU137L, GLU151J, GLU44L, GLU51L, GLU72L, GLU75J, GLU91L, GLU92L, GLU97L, GLY163J, GLY24L, GLY48J, HIS103L, HIS132J, HIS48L, HIS84J, ILE100L, ILE107L, ILE113L, ILE119J, ILE121L, ILE133J, ILE154J, ILE156J, ILE158J, ILE25L, ILE55J, ILE61L, ILE64L, ILE66J, ILE79L, ILE90J, ILE93J, ILE93L, LEU101L, LEU110L, LEU115J, LEU122J, LEU124L, LEU131L, LEU135J, LEU136J, LEU144J, LEU150J, LEU29L, LEU40L, LEU43L, LEU47L, LEU54J, LEU60L, LEU69J, LEU73J, LEU84L, LEU86J, LEU90L, LEU94J, LYS120L, LYS123J, LYS125J, LYS125L, LYS127L, LYS129J, LYS138J, LYS140L, LYS157J, LYS38L, LYS44J, LYS52J, LYS58L, LYS62L, LYS68J, LYS70J, LYS85L, LYS88L, MET147J, MET51J, MET78L, MET94L, PHE28L, PHE62J, PHE74J, PHE98J, PRO138L, PRO46J, PRO70L, SER105L, SER106L, SER112J, SER116L, SER160J, SER164J, SER166J, SER30L, SER42L, SER47J, SER55L, SER72J, SER83J, SER85J, SER86L, SER99L, THR107J, THR21L, THR22L, THR34L, THR54L, THR63J, THR83L, THR87J, THR88J, TRP41J, TYR108J, TYR109L, TYR114L, TYR32L, TYR43J, TYR68L, TYR76J, TYR96L, VAL111J, VAL121J, VAL122L, VAL126J, VAL128L, VAL130J, VAL140J, VAL36L, VAL50L, VAL57L, VAL58J
• K-L: ALA106K, ALA129L, ALA133L, ALA188K, ALA26L, ALA277K, ALA63L, ALA82L, ALA85K, ALA98L, ARG108L, ARG166K, ARG169K, ARG176K, ARG194K, ARG216K, ARG237K, ARG264K, ARG415K, ARG5L, ARG87L, ARG91K, ARG94K, ASN101K, ASN102K, ASN103K, ASN115L, ASN117L, ASN118L, ASN123L, ASN135K, ASN137K, ASN140K, ASN158K, ASN164K, ASN174K, ASN175L, ASN202K, ASN207L, ASN275K, ASN279K, ASN284K, ASN52L, ASN77L, ASP104L, ASP123K, ASP134K, ASP141L, ASP147L, ASP154K, ASP185K, ASP199L, ASP230K, ASP261K, ASP39L, ASP45L, ASP6L, ASP80L, ASP98K, CYS135L, CYS139L, CYS193K, CYS197K, CYS19L, CYS201K, CYS23L, CYS286K, CYS76K, CYS80K, CYS8L, CYS9L, GLN109K, GLN111L, GLN116K, GLN119L, GLN126K, GLN129K, GLN130L, GLN134L, GLN136L, GLN144L, GLN150K, GLN176L, GLN177L, GLN180K, GLN189K, GLN195L, GLN210L, GLN228K, GLN49L, GLN59L, GLN65L, GLN81K, GLN83K, GLN88K, GLN89K, GLU105K, GLU112L, GLU126L, GLU132L, GLU136K, GLU137L, GLU141K, GLU147K, GLU155K, GLU173K, GLU183K, GLU191K, GLU210K, GLU213K, GLU213L, GLU220K, GLU223K, GLU225L, GLU231L, GLU291K, GLU44L, GLU51L, GLU56L, GLU84K, GLU90K, GLU91L, GLU92L, GLU97L, GLU99K, GLY208K, GLY214L, GLY216L, GLY218K, GLY219K, GLY222L, GLY229L, GLY24L, GLY263K, GLY272K, GLY274K, GLY287K, GLY79K, HIS103L, HIS217L, HIS429K, HIS48L, ILE100L, ILE107L, ILE113L, ILE121L, ILE145L, ILE153K, ILE161K, ILE171K, ILE179K, ILE203K, ILE209L, ILE214K, ILE215K, ILE227K, ILE25L, ILE46L, ILE61L, ILE64L, ILE79L, ILE93K, ILE93L, LEU100K, LEU110L, LEU124L, LEU131L, LEU146K, LEU151K, LEU165K, LEU166L, LEU168K, LEU172K, LEU175K, LEU179L, LEU182K, LEU218L, LEU226K, LEU228L, LEU29L, LEU40L, LEU43L, LEU47L, LEU60L, LEU82K, LEU84L, LEU86K, LEU87K, LEU90L, LYS120L, LYS122K, LYS125L, LYS127L, LYS133K, LYS140L, LYS170L, LYS178K, LYS181K, LYS206L, LYS209K, LYS212L, LYS217K, LYS232L, LYS234K, LYS265K, LYS283K, LYS35L, LYS428K, LYS53L, LYS58L, LYS75L, LYS85L, LYS95L, MET118K, MET190K, MET224K, MET78L, MET89L, PHE115K, PHE168L, PHE178L, PHE194L, PHE215L, PHE226L, PHE262K, PHE273K, PHE28L, PRO138L, PRO162K, PRO196K, PRO204K, PRO20L, PRO220L, PRO229K, PRO235K, PRO268K, PRO77K, PRO92K, SER106L, SER108K, SER111K, SER112K, SER113K, SER114K, SER116L, SER143K, SER144K, SER159K, SER170K, SER177K, SER17L, SER184K, SER187K, SER200K, SER201L, SER207K, SER219L, SER231K, SER259K, SER30L, SER42L, SER55L, SER86L, SER96K, SER99L, THR102L, THR110K, THR142L, THR156K, THR163K, THR198K, THR21L, THR221K, THR221L, THR223L, THR224L, THR22L, THR278K, THR54L, THR67L, THR78K, THR83L, TRP125K, TRP227L, TYR109L, TYR114L, TYR117K, TYR119K, TYR142K, TYR181L, TYR18L, TYR192K, TYR211L, TYR225K, TYR236K, TYR285K, TYR292K, TYR32L, TYR378K, TYR68L, TYR96L, VAL104K, VAL107K, VAL122L, VAL128L, VAL132K, VAL138K, VAL139K, VAL143L, VAL157K, VAL167K, VAL180L, VAL186K, VAL199K, VAL202L, VAL205K, VAL206K, VAL233K, VAL260K, VAL276K, VAL36L, VAL50L, VAL57L, VAL97K
• K-T: ALA357K, ALA409K, ALA410K, ALA427K, ARG365K, ARG391K, ARG3T, ARG406K, ASN364K, ASN405K, ASN411K, ASP383K, ASP398K, ASP432K, ASP433K, CYS394K, CYS407K, GLN359K, GLN393K, GLU363K, GLU397K, GLY1T, GLY384K, GLY430K, HIS2T, HIS370K, HIS408K, LEU360K, LEU386K, LYS392K, MET361K, MET367K, MET438K, PRO4T, SER443K, THR366K, THR368K, THR387K, THR431K, TRP385K, TRP444K, TYR404K, TYR422K, VAL436K
• L-R: ALA327L, ALA341L, ALA370L, ARG375L, ARG3R, ASN325L, ASN337L, ASN361L, ASN365L, ASP294L, ASP297L, ASP298L, ASP301L, ASP320L, ASP330L, ASP364L, CYS326L, CYS339L, GLN329L, GLU323L, GLU328L, GLY1R, GLY296L, GLY324L, GLY331L, GLY342L, GLY362L, GLY366L, HIS307L, HIS340L, HIS343L, ILE368L, LYS302L, LYS321L, LYS338L, MET336L, PHE293L, PHE295L, PHE304L, PHE322L, PRO2R, PRO4R, SER300L, THR305L, THR359L, TRP376L, TYR354L, TYR363L