3GE4

crystal structure of ferritin:dna-binding protein dps from brucella melitensis

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 81
  • Norm. En. per Res.: -5.2835
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-84.553	-80.2489	-363.507	-528.3089	131	14	3	15237	6	36	39
A-C	-52.0379	-123.5353	-226.331	-401.9042	80	5	0	7803	8	49	48
A-D	-32.2426	10.2217	-180.296	-202.3168	53	7	5	6033	0	11	14
A-E	-62.0801	-97.0083	-236.505	-395.5934	80	7	0	8015	7	49	48
A-F	-36.4955	8.1017	-186.38	-214.7738	53	5	5	6105	0	12	13
B-C	-40.0637	11.0076	-180.878	-209.9341	52	11	5	6128	0	12	13
B-D	-66.0408	-132.97	-228.952	-427.9628	81	10	0	7944	7	49	47
B-K	-40.008	10.1976	-183.072	-212.8824	52	6	5	6056	0	11	13
B-L	-56.9023	-106.6572	-231.111	-394.6705	79	8	0	7929	7	49	48
C-E	-55.5237	-128.1218	-230.784	-414.4295	80	8	0	7934	8	48	47
C-I	-67.5269	-50.3217	-363.774	-481.6226	135	18	2	15297	6	38	39
C-K	-39.4392	8.1151	-185.302	-216.6261	50	6	5	6073	0	12	13
D-F	-40.986	9.7223	-190.106	-221.3698	52	8	5	6211	0	12	13
D-J	-79.0671	-80.8032	-364.929	-524.7993	136	14	3	15294	6	37	39
D-L	-44.2916	-101.0659	-228.129	-373.4865	78	7	0	7826	5	49	48
E-F	-89.732	-85.8925	-382.091	-557.7155	136	10	2	15712	8	37	39
E-H	-35.5938	8.3459	-185.733	-212.9809	52	6	5	6087	0	12	13
E-I	-41.0032	10.2385	-184.411	-215.1757	53	7	5	6143	0	11	13
F-H	-57.8705	-104.101	-233.69	-395.6615	79	10	0	7979	7	49	48
F-J	-54.3799	-103.6867	-239.328	-397.3945	80	7	0	8004	7	49	48
G-H	-78.4089	-63.4013	-362.004	-503.8142	135	14	2	15329	6	37	38
G-I	-68.0549	-116.2049	-231.186	-415.4458	80	11	0	8137	7	49	46
G-J	-37.7596	10.8272	-186.547	-213.4794	54	5	5	6157	0	12	13
G-K	-66.5179	-110.2388	-226.079	-402.8357	80	12	0	7941	8	49	48
G-L	-39.6096	8.4096	-189.943	-221.143	53	6	5	6196	0	12	13
H-I	-35.4046	10.4768	-186.124	-211.0519	52	4	5	6101	0	12	13
H-J	-50.874	-109.6489	-231.349	-391.8718	81	8	0	7946	7	49	48
I-K	-56.6084	-99.3025	-220.97	-376.8808	77	12	0	7771	7	49	47
J-L	-34.095	10.1287	-185.443	-209.4093	53	5	5	6082	0	12	13
K-L	-84.8502	-85.5243	-389.368	-559.7425	137	22	3	15889	8	38	38

Interface residues

• A-B: ALA106A, ALA106B, ALA31A, ALA31B, ALA37A, ALA37B, ALA43A, ALA43B, ALA74A, ALA74B, ALA77A, ALA77B, ALA84A, ALA84B, ALA9A, ALA9B, ARG117A, ARG117B, ARG63A, ARG63B, ARG76A, ARG76B, ARG96B, ASN46A, ASN46B, ASP103A, ASP103B, ASP35A, ASP35B, ASP60A, ASP60B, ASP67A, ASP67B, ASP68A, ASP68B, ASP71A, ASP71B, GLN42A, GLN42B, GLN79A, GLN79B, GLN89A, GLN89B, GLU75A, GLU75B, GLY81A, GLY81B, GLY82A, GLY82B, GLY86A, GLY86B, HIS110A, HIS110B, HIS44A, HIS44B, HIS56A, HIS56B, HIS69A, HIS69B, HIS8A, HIS8B, ILE104A, ILE104B, ILE34A, ILE34B, ILE39A, ILE39B, ILE73A, ILE73B, LEU30A, LEU30B, LEU36A, LEU36B, LEU38A, LEU38B, LEU47A, LEU47B, LEU97A, LEU97B, LYS41A, LYS41B, LYS48A, LYS48B, LYS93A, LYS93B, LYS98A, LYS98B, MET7A, MET7B, PHE52A, PHE52B, PRO101A, PRO101B, PRO99A, PRO99B, SER6A, SER6B, SER95A, SER95B, THR102A, THR102B, THR10A, THR10B, THR40A, THR40B, THR72A, THR72B, THR83A, THR83B, THR87A, THR87B, THR88A, THR88B, TRP45A, TRP45B, TYR100A, TYR100B, TYR105A, TYR105B, TYR85A, TYR85B, VAL70A, VAL70B, VAL78A, VAL78B, VAL90A, VAL90B, VAL91A, VAL91B, VAL92A, VAL92B
• A-C: ALA113C, ALA122C, ALA141A, ALA141C, ALA146A, ALA146C, ALA147A, ALA147C, ALA154C, ALA160C, ALA74A, ALA9A, ARG117C, ARG11A, ARG126C, ARG149C, ARG76A, ASN123C, ASN12A, ASP120C, ASP131C, ASP133A, ASP133C, ASP137A, ASP138A, ASP139A, ASP13A, ASP142A, ASP142C, ASP152C, ASP68A, ASP71A, GLN163C, GLN79A, GLU116C, GLU159C, GLU164C, GLU75A, GLY119C, GLY136A, GLY81A, GLY82A, HIS69A, HIS8A, ILE115C, ILE129C, ILE143A, ILE73A, ILE80A, LEU114C, LEU124C, LEU14A, LEU151C, LEU155C, LEU97C, LYS127C, LYS130C, LYS153C, LYS19A, MET7A, PHE144A, PHE144C, PHE157C, PRO15A, SER148C, SER150C, SER165C, THR10A, THR140A, THR145A, THR145C, THR18A, THR72A, TRP156C, TYR118C, VAL112C, VAL121C, VAL125C, VAL162C, VAL78A
• A-D: ALA106A, ALA154D, ALA160D, ALA43A, ALA54A, ALA54D, ASN166A, ASN166D, ASN46A, ASP109A, ASP60A, GLN163D, GLN51A, GLN51D, GLU159D, GLU164D, GLU57A, GLU57D, GLY49A, GLY61D, HIS108A, HIS108D, HIS110A, HIS161D, HIS44A, HIS56A, HIS56D, ILE104A, ILE53A, ILE53D, LEU111A, LEU111D, LEU158D, LEU47A, LEU59D, LYS153D, LYS48A, MET58D, PHE157D, PHE52A, PHE62D, PRO50A, PRO50D, SER165D, TRP156D, TRP45A, TYR105A, VAL107A, VAL107D, VAL112A, VAL162D, VAL55A, VAL55D
• A-E: ALA113A, ALA122A, ALA141A, ALA141E, ALA146A, ALA146E, ALA147A, ALA147E, ALA154A, ALA160A, ALA74E, ALA9E, ARG117A, ARG11E, ARG126A, ARG149A, ARG76E, ASN123A, ASN12E, ASP120A, ASP131A, ASP133A, ASP133E, ASP137E, ASP138E, ASP139E, ASP13E, ASP142A, ASP142E, ASP152A, ASP68E, ASP71E, GLN163A, GLN79E, GLU116A, GLU159A, GLU164A, GLU75E, GLY119A, GLY136E, GLY81E, GLY82E, HIS69E, HIS8E, ILE115A, ILE129A, ILE143E, ILE73E, ILE80E, LEU114A, LEU124A, LEU14E, LEU151A, LEU155A, LEU97A, LYS127A, LYS130A, LYS153A, LYS19E, LYS98A, MET7E, PHE144A, PHE144E, PHE157A, PRO15E, SER148A, SER150A, SER165A, THR10E, THR140E, THR145A, THR145E, THR72E, TRP156A, TYR118A, VAL112A, VAL121A, VAL125A, VAL162A, VAL78E
• A-F: ALA106F, ALA154A, ALA160A, ALA43F, ALA54A, ALA54F, ASN166A, ASN166F, ASN46F, ASP109F, ASP60F, GLN163A, GLN51A, GLN51F, GLU159A, GLU164A, GLU57A, GLU57F, GLY49F, GLY61A, HIS108A, HIS108F, HIS110F, HIS161A, HIS44F, HIS56A, HIS56F, ILE104F, ILE53A, ILE53F, LEU111A, LEU111F, LEU158A, LEU47F, LEU59A, LYS153A, LYS48F, MET58A, PHE157A, PHE52F, PHE62A, PRO50A, PRO50F, SER165A, TRP156A, TRP45F, TYR105F, VAL107A, VAL107F, VAL112F, VAL162A, VAL55A, VAL55F
• B-C: ALA106B, ALA154C, ALA160C, ALA43B, ALA54B, ALA54C, ASN166B, ASN166C, ASN46B, ASP109B, ASP60B, GLN163C, GLN51B, GLN51C, GLU159C, GLU164C, GLU57B, GLU57C, GLY49B, HIS108B, HIS108C, HIS110B, HIS161C, HIS44B, HIS56B, HIS56C, ILE104B, ILE53B, ILE53C, LEU111B, LEU111C, LEU158C, LEU47B, LEU59C, LYS153C, LYS48B, MET58C, PHE157C, PHE52B, PHE62C, PRO50B, PRO50C, SER165C, TRP156C, TRP45B, TYR105B, VAL107B, VAL107C, VAL112B, VAL162C, VAL55B, VAL55C
• B-D: ALA113D, ALA122D, ALA141B, ALA141D, ALA146B, ALA146D, ALA147B, ALA147D, ALA154D, ALA160D, ALA74B, ALA9B, ARG117D, ARG11B, ARG126D, ARG149D, ARG76B, ASN123D, ASN12B, ASP120D, ASP131D, ASP133B, ASP133D, ASP137B, ASP138B, ASP139B, ASP13B, ASP142B, ASP142D, ASP152D, ASP68B, ASP71B, GLN163D, GLN79B, GLU116D, GLU159D, GLU164D, GLU75B, GLY119D, GLY136B, GLY81B, GLY82B, HIS69B, HIS8B, ILE115D, ILE129D, ILE143B, ILE73B, ILE80B, LEU114D, LEU124D, LEU14B, LEU151D, LEU155D, LYS127D, LYS130D, LYS153D, LYS19B, LYS98D, MET7B, PHE144B, PHE144D, PHE157D, PRO15B, SER128D, SER148D, SER150D, SER165D, THR10B, THR140B, THR145B, THR145D, THR18B, THR72B, TRP156D, TYR118D, VAL112D, VAL121D, VAL125D, VAL162D, VAL78B
• B-K: ALA106K, ALA154B, ALA160B, ALA43K, ALA54B, ALA54K, ASN166B, ASN166K, ASN46K, ASP109K, ASP60K, GLN163B, GLN51B, GLN51K, GLU159B, GLU164B, GLU57B, GLU57K, GLY49K, GLY61B, HIS108B, HIS108K, HIS110K, HIS161B, HIS44K, HIS56B, HIS56K, ILE104K, ILE53B, ILE53K, LEU111B, LEU111K, LEU158B, LEU47K, LEU59B, LYS153B, LYS48K, MET58B, PHE157B, PHE52K, PHE62B, PRO50B, PRO50K, SER165B, TRP156B, TRP45K, TYR105K, VAL107B, VAL107K, VAL162B, VAL55B, VAL55K
• B-L: ALA113B, ALA122B, ALA141B, ALA141L, ALA146B, ALA146L, ALA147B, ALA147L, ALA154B, ALA160B, ALA74L, ALA9L, ARG117B, ARG11L, ARG126B, ARG149B, ARG76L, ASN123B, ASN12L, ASP120B, ASP131B, ASP133B, ASP133L, ASP137L, ASP138L, ASP139L, ASP13L, ASP142B, ASP142L, ASP152B, ASP68L, ASP71L, GLN163B, GLN79L, GLU116B, GLU159B, GLU164B, GLU75L, GLY119B, GLY136L, GLY81L, GLY82L, HIS69L, HIS8L, ILE115B, ILE129B, ILE143L, ILE73L, ILE80L, LEU114B, LEU124B, LEU14L, LEU151B, LEU155B, LYS127B, LYS130B, LYS153B, LYS19L, MET7L, PHE144B, PHE144L, PHE157B, PRO15L, SER148B, SER150B, SER165B, THR10L, THR140L, THR145B, THR145L, THR18L, THR72L, TRP156B, TYR118B, VAL112B, VAL121B, VAL125B, VAL162B, VAL78L
• C-E: ALA113E, ALA122E, ALA141C, ALA141E, ALA146C, ALA146E, ALA147C, ALA147E, ALA154E, ALA160E, ALA74C, ALA9C, ARG117E, ARG11C, ARG126E, ARG149E, ARG76C, ASN123E, ASN12C, ASP120E, ASP131E, ASP133C, ASP133E, ASP137C, ASP138C, ASP139C, ASP13C, ASP142C, ASP142E, ASP152E, ASP68C, ASP71C, GLN163E, GLN79C, GLU116E, GLU159E, GLU164E, GLU75C, GLY119E, GLY136C, GLY81C, GLY82C, HIS69C, HIS8C, ILE115E, ILE129E, ILE143C, ILE73C, ILE80C, LEU114E, LEU124E, LEU14C, LEU151E, LEU155E, LYS127E, LYS130E, LYS153E, LYS19C, LYS98E, MET7C, PHE144C, PHE144E, PHE157E, PRO15C, SER148E, SER150E, SER165E, THR10C, THR140C, THR145C, THR145E, THR18C, THR72C, TRP156E, TYR118E, VAL112E, VAL121E, VAL125E, VAL162E, VAL78C
• C-I: ALA106C, ALA106I, ALA31C, ALA31I, ALA37C, ALA37I, ALA43C, ALA43I, ALA74C, ALA74I, ALA77C, ALA77I, ALA84C, ALA84I, ALA9C, ALA9I, ARG117C, ARG117I, ARG63C, ARG63I, ARG76C, ARG76I, ARG96C, ARG96I, ASN27I, ASN46C, ASN46I, ASP103C, ASP103I, ASP35C, ASP35I, ASP60C, ASP60I, ASP67C, ASP67I, ASP68C, ASP68I, ASP71C, ASP71I, GLN42C, GLN42I, GLN79C, GLN79I, GLN89C, GLN89I, GLU75C, GLU75I, GLU94C, GLY81C, GLY81I, GLY82C, GLY82I, GLY86C, GLY86I, HIS110C, HIS110I, HIS44C, HIS44I, HIS56C, HIS56I, HIS69C, HIS69I, HIS8C, HIS8I, ILE104C, ILE104I, ILE34C, ILE34I, ILE39C, ILE39I, ILE73C, ILE73I, LEU30C, LEU30I, LEU36C, LEU36I, LEU38C, LEU38I, LEU47C, LEU47I, LEU97C, LEU97I, LYS41C, LYS41I, LYS48C, LYS48I, LYS93C, LYS93I, LYS98C, LYS98I, MET7C, MET7I, PHE52C, PHE52I, PRO101C, PRO101I, PRO99C, PRO99I, SER6C, SER6I, SER95C, SER95I, THR102C, THR102I, THR10C, THR10I, THR33C, THR40C, THR40I, THR72C, THR72I, THR83C, THR83I, THR87C, THR87I, THR88C, THR88I, TRP45C, TRP45I, TYR100C, TYR100I, TYR105C, TYR105I, TYR85C, TYR85I, VAL70C, VAL70I, VAL78C, VAL78I, VAL90C, VAL90I, VAL91C, VAL91I, VAL92C, VAL92I
• C-K: ALA106C, ALA154K, ALA160K, ALA43C, ALA54C, ALA54K, ASN166C, ASN166K, ASN46C, ASP109C, GLN163K, GLN51C, GLN51K, GLU159K, GLU164K, GLU57C, GLU57K, GLY49C, HIS108C, HIS108K, HIS110C, HIS161K, HIS44C, HIS56C, HIS56K, ILE104C, ILE53C, ILE53K, LEU111C, LEU111K, LEU158K, LEU47C, LEU59K, LYS153K, LYS48C, MET58K, PHE157K, PHE52C, PHE62K, PRO50C, PRO50K, SER165K, TRP156K, TRP45C, TYR105C, VAL107C, VAL107K, VAL162K, VAL55C, VAL55K
• D-F: ALA106D, ALA154F, ALA160F, ALA43D, ALA54D, ALA54F, ASN166D, ASN166F, ASN46D, ASP103D, ASP109D, ASP60D, GLN163F, GLN51D, GLN51F, GLU159F, GLU164F, GLU57D, GLU57F, GLY49D, HIS108D, HIS108F, HIS110D, HIS161F, HIS44D, HIS56D, HIS56F, ILE104D, ILE53D, ILE53F, LEU111D, LEU111F, LEU158F, LEU47D, LEU59F, LYS153F, LYS48D, MET58F, PHE157F, PHE52D, PHE62F, PRO50D, PRO50F, SER165F, TRP156F, TRP45D, TYR105D, VAL107D, VAL107F, VAL162F, VAL55D, VAL55F
• D-J: ALA106D, ALA106J, ALA31D, ALA31J, ALA37D, ALA37J, ALA43D, ALA43J, ALA64J, ALA74D, ALA74J, ALA77D, ALA77J, ALA84D, ALA84J, ALA9D, ALA9J, ARG117D, ARG117J, ARG63D, ARG63J, ARG76D, ARG76J, ARG96D, ARG96J, ASN27D, ASN27J, ASN46D, ASN46J, ASP103D, ASP103J, ASP35D, ASP35J, ASP60D, ASP60J, ASP67D, ASP67J, ASP68D, ASP68J, ASP71D, ASP71J, GLN42D, GLN42J, GLN79D, GLN79J, GLN89D, GLN89J, GLU75D, GLU75J, GLU94D, GLY81D, GLY81J, GLY82D, GLY82J, GLY86D, GLY86J, HIS110D, HIS110J, HIS44D, HIS44J, HIS56D, HIS56J, HIS69D, HIS69J, HIS8D, HIS8J, ILE104D, ILE104J, ILE34D, ILE34J, ILE39D, ILE39J, ILE73D, ILE73J, LEU30D, LEU30J, LEU36D, LEU36J, LEU38D, LEU38J, LEU47D, LEU47J, LEU97D, LEU97J, LYS41D, LYS41J, LYS48D, LYS48J, LYS93D, LYS93J, LYS98D, LYS98J, MET7D, MET7J, PHE52D, PHE52J, PRO101D, PRO101J, PRO99D, PRO99J, SER6D, SER6J, SER95D, SER95J, THR102D, THR102J, THR10D, THR10J, THR40D, THR40J, THR72D, THR72J, THR83D, THR83J, THR87D, THR87J, THR88D, THR88J, TRP45D, TRP45J, TYR100D, TYR100J, TYR105D, TYR105J, TYR85D, TYR85J, VAL70D, VAL70J, VAL78D, VAL78J, VAL90D, VAL90J, VAL91D, VAL91J, VAL92D, VAL92J
• D-L: ALA113L, ALA122L, ALA141D, ALA141L, ALA146D, ALA146L, ALA147D, ALA147L, ALA154L, ALA160L, ALA74D, ALA9D, ARG117L, ARG11D, ARG126L, ARG149L, ARG76D, ASN123L, ASN12D, ASP120L, ASP131L, ASP133D, ASP133L, ASP137D, ASP138D, ASP139D, ASP13D, ASP142D, ASP142L, ASP152L, ASP68D, ASP71D, GLN163L, GLN79D, GLU116L, GLU159L, GLU164L, GLU75D, GLY119L, GLY136D, GLY81D, GLY82D, HIS69D, HIS8D, ILE115L, ILE129L, ILE143D, ILE73D, ILE80D, LEU114L, LEU124L, LEU14D, LEU151L, LEU155L, LYS127L, LYS130L, LYS153L, LYS19D, MET7D, PHE144D, PHE144L, PHE157L, PRO15D, SER148L, SER150L, SER165L, THR10D, THR140D, THR145D, THR145L, THR18D, THR72D, TRP156L, TYR118L, VAL112L, VAL125L, VAL162L, VAL78D
• E-F: ALA106E, ALA106F, ALA31E, ALA31F, ALA37E, ALA37F, ALA43E, ALA43F, ALA64E, ALA74E, ALA74F, ALA77E, ALA77F, ALA84E, ALA84F, ALA9E, ALA9F, ARG117E, ARG117F, ARG63E, ARG63F, ARG76E, ARG76F, ARG96E, ARG96F, ASN27E, ASN27F, ASN46E, ASN46F, ASP103E, ASP103F, ASP35E, ASP35F, ASP60E, ASP60F, ASP67E, ASP67F, ASP68E, ASP68F, ASP71E, ASP71F, GLN42E, GLN42F, GLN79E, GLN79F, GLN89E, GLN89F, GLU75E, GLU75F, GLU94F, GLY81E, GLY81F, GLY82E, GLY82F, GLY86E, GLY86F, HIS110E, HIS110F, HIS44E, HIS44F, HIS56E, HIS56F, HIS69E, HIS69F, HIS8E, HIS8F, ILE104E, ILE104F, ILE34E, ILE34F, ILE39E, ILE39F, ILE73E, ILE73F, LEU30E, LEU30F, LEU36E, LEU36F, LEU38E, LEU38F, LEU47E, LEU47F, LEU97E, LEU97F, LYS41E, LYS41F, LYS48E, LYS48F, LYS93E, LYS93F, LYS98E, LYS98F, MET7E, MET7F, PHE52E, PHE52F, PRO101E, PRO101F, PRO99E, PRO99F, SER6E, SER6F, SER95E, SER95F, THR102E, THR102F, THR10E, THR10F, THR40E, THR40F, THR72E, THR72F, THR83E, THR83F, THR87E, THR87F, THR88E, THR88F, TRP45E, TRP45F, TYR100E, TYR100F, TYR105E, TYR105F, TYR85E, TYR85F, VAL70E, VAL70F, VAL78E, VAL78F, VAL90E, VAL90F, VAL91E, VAL91F, VAL92E, VAL92F
• E-H: ALA106E, ALA154H, ALA160H, ALA43E, ALA54E, ALA54H, ASN166E, ASN166H, ASN46E, ASP109E, GLN163H, GLN51E, GLN51H, GLU159H, GLU164H, GLU57E, GLU57H, GLY49E, GLY61H, HIS108E, HIS108H, HIS110E, HIS161H, HIS44E, HIS56E, HIS56H, ILE104E, ILE53E, ILE53H, LEU111E, LEU111H, LEU158H, LEU47E, LEU59H, LYS153H, LYS48E, MET58H, PHE157H, PHE52E, PHE62H, PRO50E, PRO50H, SER165H, TRP156H, TRP45E, TYR105E, VAL107E, VAL107H, VAL112E, VAL162H, VAL55E, VAL55H
• E-I: ALA106I, ALA154E, ALA160E, ALA43I, ALA54E, ALA54I, ASN166E, ASN166I, ASN46I, ASP109I, ASP60I, GLN163E, GLN51E, GLN51I, GLU159E, GLU164E, GLU57E, GLU57I, GLY49I, GLY61E, HIS108E, HIS108I, HIS110I, HIS161E, HIS44I, HIS56E, HIS56I, ILE104I, ILE53E, ILE53I, LEU111E, LEU111I, LEU158E, LEU47I, LEU59E, LYS153E, LYS48I, MET58E, PHE157E, PHE52I, PHE62E, PRO50E, PRO50I, SER165E, TRP156E, TRP45I, TYR105I, VAL107E, VAL107I, VAL112I, VAL162E, VAL55E, VAL55I
• F-H: ALA113H, ALA122H, ALA141F, ALA141H, ALA146F, ALA146H, ALA147F, ALA147H, ALA154H, ALA160H, ALA74F, ALA9F, ARG117H, ARG11F, ARG126H, ARG149H, ARG76F, ASN123H, ASN12F, ASP120H, ASP131H, ASP133F, ASP133H, ASP137F, ASP138F, ASP139F, ASP13F, ASP142F, ASP142H, ASP152H, ASP68F, ASP71F, GLN163H, GLN79F, GLU116H, GLU159H, GLU164H, GLU75F, GLY119H, GLY136F, GLY81F, GLY82F, HIS69F, HIS8F, ILE115H, ILE129H, ILE143F, ILE73F, ILE80F, LEU114H, LEU124H, LEU14F, LEU151H, LEU155H, LYS127H, LYS130H, LYS153H, LYS19F, MET7F, PHE144F, PHE144H, PHE157H, PRO15F, SER148H, SER150H, SER165H, THR10F, THR140F, THR145F, THR145H, THR18F, THR72F, TRP156H, TYR118H, VAL112H, VAL121H, VAL125H, VAL162H, VAL78F
• F-J: ALA113F, ALA122F, ALA141F, ALA141J, ALA146F, ALA146J, ALA147F, ALA147J, ALA154F, ALA160F, ALA74J, ALA9J, ARG117F, ARG11J, ARG126F, ARG149F, ARG76J, ASN123F, ASN12J, ASP120F, ASP131F, ASP133F, ASP133J, ASP137J, ASP138J, ASP139J, ASP13J, ASP142F, ASP142J, ASP152F, ASP68J, ASP71J, GLN163F, GLN79J, GLU116F, GLU159F, GLU164F, GLU75J, GLY119F, GLY136J, GLY81J, GLY82J, HIS69J, HIS8J, ILE115F, ILE129F, ILE143J, ILE73J, ILE80J, LEU114F, LEU124F, LEU14J, LEU151F, LEU155F, LEU97F, LYS127F, LYS130F, LYS153F, LYS19J, MET7J, PHE144F, PHE144J, PHE157F, PRO15J, SER148F, SER150F, SER165F, THR10J, THR140J, THR145F, THR145J, THR18J, THR72J, TRP156F, TYR118F, VAL112F, VAL121F, VAL125F, VAL162F, VAL78J
• G-H: ALA106G, ALA106H, ALA31G, ALA31H, ALA37G, ALA37H, ALA43G, ALA43H, ALA74G, ALA74H, ALA77G, ALA77H, ALA84G, ALA84H, ALA9G, ALA9H, ARG117G, ARG117H, ARG63G, ARG63H, ARG76G, ARG76H, ARG96G, ARG96H, ASN27G, ASN27H, ASN46G, ASN46H, ASP103G, ASP103H, ASP35G, ASP35H, ASP60G, ASP60H, ASP67G, ASP67H, ASP68G, ASP68H, ASP71G, ASP71H, GLN42G, GLN42H, GLN79G, GLN79H, GLN89G, GLN89H, GLU75G, GLU75H, GLY81G, GLY81H, GLY82G, GLY82H, GLY86G, GLY86H, HIS110G, HIS110H, HIS44G, HIS44H, HIS56G, HIS56H, HIS69G, HIS69H, HIS8G, HIS8H, ILE104G, ILE104H, ILE34G, ILE34H, ILE39G, ILE39H, ILE73G, ILE73H, LEU30G, LEU30H, LEU36G, LEU36H, LEU38G, LEU38H, LEU47G, LEU47H, LEU97G, LEU97H, LYS41G, LYS41H, LYS48G, LYS48H, LYS93G, LYS93H, LYS98G, LYS98H, MET7G, MET7H, PHE52G, PHE52H, PRO101G, PRO101H, PRO99G, PRO99H, SER6G, SER6H, SER95G, SER95H, THR102G, THR102H, THR10G, THR10H, THR33H, THR40G, THR40H, THR72G, THR72H, THR83G, THR83H, THR87G, THR87H, THR88G, THR88H, TRP45G, TRP45H, TYR100G, TYR100H, TYR105G, TYR105H, TYR85G, TYR85H, VAL70G, VAL70H, VAL78G, VAL78H, VAL90G, VAL90H, VAL91G, VAL91H, VAL92G, VAL92H
• G-I: ALA113I, ALA122I, ALA135G, ALA141G, ALA141I, ALA146G, ALA146I, ALA147G, ALA147I, ALA154I, ALA160I, ALA74G, ALA9G, ARG117I, ARG11G, ARG126I, ARG149I, ARG76G, ASN123I, ASN12G, ASP120I, ASP131I, ASP133G, ASP133I, ASP137G, ASP138G, ASP139G, ASP13G, ASP142G, ASP142I, ASP152I, ASP68G, ASP71G, GLN163I, GLN79G, GLU116I, GLU159I, GLU164I, GLU75G, GLY119I, GLY136G, GLY81G, GLY82G, HIS69G, HIS8G, ILE115I, ILE129I, ILE143G, ILE73G, ILE80G, LEU114I, LEU124I, LEU14G, LEU151I, LEU155I, LYS127I, LYS130I, LYS153I, LYS19G, MET7G, PHE144G, PHE144I, PHE157I, PRO15G, SER148I, SER150I, SER165I, THR10G, THR140G, THR145G, THR145I, THR18G, THR72G, TRP156I, TYR118I, VAL112I, VAL121I, VAL125I, VAL162I, VAL78G
• G-J: ALA106G, ALA154J, ALA160J, ALA43G, ALA54G, ALA54J, ASN166G, ASN166J, ASN46G, ASP103G, ASP109G, ASP60G, GLN163J, GLN51G, GLN51J, GLU159J, GLU164J, GLU57G, GLU57J, GLY49G, GLY61J, HIS108G, HIS108J, HIS110G, HIS161J, HIS44G, HIS56G, HIS56J, ILE104G, ILE53G, ILE53J, LEU111G, LEU111J, LEU158J, LEU47G, LEU59J, LYS153J, LYS48G, MET58J, PHE157J, PHE52G, PHE62J, PRO50G, PRO50J, SER165J, TRP156J, TRP45G, TYR105G, VAL107G, VAL107J, VAL112G, VAL162J, VAL55G, VAL55J
• G-K: ALA113G, ALA122G, ALA141G, ALA141K, ALA146G, ALA146K, ALA147G, ALA147K, ALA154G, ALA160G, ALA74K, ALA9K, ARG117G, ARG11K, ARG126G, ARG149G, ARG76K, ASN123G, ASN12K, ASP120G, ASP131G, ASP133G, ASP133K, ASP137K, ASP138K, ASP139K, ASP13K, ASP142G, ASP142K, ASP152G, ASP68K, ASP71K, GLN163G, GLN79K, GLU116G, GLU159G, GLU164G, GLU75K, GLY119G, GLY136K, GLY81K, GLY82K, HIS69K, HIS8K, ILE115G, ILE129G, ILE143K, ILE73K, ILE80K, LEU114G, LEU124G, LEU14K, LEU151G, LEU155G, LYS127G, LYS130G, LYS153G, LYS19K, LYS98G, MET7K, PHE144G, PHE144K, PHE157G, PRO15K, SER148G, SER150G, SER165G, THR10K, THR140K, THR145G, THR145K, THR18K, THR72K, TRP156G, TYR118G, VAL112G, VAL121G, VAL125G, VAL162G, VAL78K
• G-L: ALA106L, ALA154G, ALA160G, ALA43L, ALA54G, ALA54L, ASN166G, ASN166L, ASN46L, ASP109L, ASP60L, GLN163G, GLN51G, GLN51L, GLU159G, GLU164G, GLU57G, GLU57L, GLY49L, GLY61G, HIS108G, HIS108L, HIS110L, HIS161G, HIS44L, HIS56G, HIS56L, ILE104L, ILE53G, ILE53L, LEU111G, LEU111L, LEU158G, LEU47L, LEU59G, LYS153G, LYS48L, MET58G, PHE157G, PHE52L, PHE62G, PRO50G, PRO50L, SER165G, TRP156G, TRP45L, TYR105L, VAL107G, VAL107L, VAL112L, VAL162G, VAL55G, VAL55L
• H-I: ALA106H, ALA154I, ALA160I, ALA43H, ALA54H, ALA54I, ASN166H, ASN166I, ASN46H, ASP109H, ASP60H, GLN163I, GLN51H, GLN51I, GLU159I, GLU164I, GLU57H, GLU57I, GLY49H, HIS108H, HIS108I, HIS110H, HIS161I, HIS44H, HIS56H, HIS56I, ILE104H, ILE53H, ILE53I, LEU111H, LEU111I, LEU158I, LEU47H, LEU59I, LYS153I, LYS48H, MET58I, PHE157I, PHE52H, PHE62I, PRO50H, PRO50I, SER165I, TRP156I, TRP45H, TYR105H, VAL107H, VAL107I, VAL112H, VAL162I, VAL55H, VAL55I
• H-J: ALA113J, ALA122J, ALA141H, ALA141J, ALA146H, ALA146J, ALA147H, ALA147J, ALA154J, ALA160J, ALA74H, ALA9H, ARG117J, ARG11H, ARG126J, ARG149J, ARG76H, ASN123J, ASN12H, ASP120J, ASP131J, ASP133H, ASP133J, ASP137H, ASP138H, ASP139H, ASP13H, ASP142H, ASP142J, ASP152J, ASP68H, ASP71H, GLN163J, GLN79H, GLU116J, GLU159J, GLU164J, GLU75H, GLY119J, GLY136H, GLY81H, GLY82H, HIS69H, HIS8H, ILE115J, ILE129J, ILE143H, ILE73H, ILE80H, LEU114J, LEU124J, LEU14H, LEU151J, LEU155J, LEU97J, LYS127J, LYS130J, LYS153J, LYS19H, MET7H, PHE144H, PHE144J, PHE157J, PRO15H, SER128J, SER148J, SER150J, SER165J, THR10H, THR140H, THR145H, THR145J, THR18H, THR72H, TRP156J, TYR118J, VAL112J, VAL121J, VAL125J, VAL162J, VAL78H
• I-K: ALA122K, ALA141I, ALA141K, ALA146I, ALA146K, ALA147I, ALA147K, ALA154K, ALA160K, ALA74I, ALA9I, ARG117K, ARG11I, ARG126K, ARG149K, ARG76I, ASN123K, ASN12I, ASP120K, ASP131K, ASP133I, ASP133K, ASP137I, ASP138I, ASP139I, ASP13I, ASP142I, ASP142K, ASP152K, ASP68I, ASP71I, GLN163K, GLN79I, GLU116K, GLU159K, GLU164K, GLU75I, GLY119K, GLY136I, GLY81I, GLY82I, HIS69I, HIS8I, ILE115K, ILE129K, ILE143I, ILE73I, ILE80I, LEU114K, LEU124K, LEU14I, LEU151K, LEU155K, LYS127K, LYS130K, LYS153K, LYS19I, MET7I, PHE144I, PHE144K, PHE157K, PRO15I, SER148K, SER150K, SER165K, THR10I, THR140I, THR145I, THR145K, THR18I, THR72I, TRP156K, TYR118K, VAL112K, VAL125K, VAL162K, VAL78I
• J-L: ALA106J, ALA154L, ALA160L, ALA43J, ALA54J, ALA54L, ASN166J, ASN166L, ASN46J, ASP109J, ASP60J, GLN163L, GLN51J, GLN51L, GLU159L, GLU164L, GLU57J, GLU57L, GLY49J, GLY61L, HIS108J, HIS108L, HIS110J, HIS161L, HIS44J, HIS56J, HIS56L, ILE104J, ILE53J, ILE53L, LEU111J, LEU111L, LEU158L, LEU47J, LEU59L, LYS153L, LYS48J, MET58L, PHE157L, PHE52J, PHE62L, PRO50J, PRO50L, SER165L, TRP156L, TRP45J, TYR105J, VAL107J, VAL107L, VAL112J, VAL162L, VAL55J, VAL55L
• K-L: ALA106K, ALA106L, ALA31K, ALA31L, ALA37K, ALA37L, ALA43K, ALA43L, ALA74K, ALA74L, ALA77K, ALA77L, ALA84K, ALA84L, ALA9K, ALA9L, ARG117K, ARG117L, ARG63K, ARG63L, ARG76K, ARG76L, ARG96K, ASN27K, ASN27L, ASN46K, ASN46L, ASP103K, ASP103L, ASP35K, ASP35L, ASP60K, ASP60L, ASP67K, ASP67L, ASP68K, ASP68L, ASP71K, ASP71L, GLN42K, GLN42L, GLN79K, GLN79L, GLN89K, GLN89L, GLU75K, GLU75L, GLU94K, GLU94L, GLY81K, GLY81L, GLY82K, GLY82L, GLY86K, GLY86L, HIS110K, HIS110L, HIS44K, HIS44L, HIS56K, HIS56L, HIS69K, HIS69L, HIS8K, HIS8L, ILE104K, ILE104L, ILE34K, ILE34L, ILE39K, ILE39L, ILE73K, ILE73L, LEU30K, LEU30L, LEU36K, LEU36L, LEU38K, LEU38L, LEU47K, LEU47L, LEU97K, LEU97L, LYS41K, LYS41L, LYS48K, LYS48L, LYS93K, LYS93L, LYS98K, LYS98L, MET7K, MET7L, PHE52K, PHE52L, PRO101K, PRO101L, PRO99K, PRO99L, SER6K, SER6L, SER95K, SER95L, THR102K, THR102L, THR10K, THR10L, THR33K, THR33L, THR40K, THR40L, THR72K, THR72L, THR83K, THR83L, THR87K, THR87L, THR88K, THR88L, TRP45K, TRP45L, TYR100K, TYR100L, TYR105K, TYR105L, TYR85K, TYR85L, VAL70K, VAL70L, VAL78K, VAL78L, VAL90K, VAL90L, VAL91K, VAL91L, VAL92K, VAL92L