3GD1

structure of an arrestin/clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-E
  • Int. Res.: 74
  • Norm. En. per Res.: -4.7797
• Hub Node: C(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
C-E	-62.5035	-71.1146	-220.083	-353.7012	74	24	4	6864	4	15	13
C-I	0.0	-6.3407	-11.0165	-17.3572	15	0	0	619	0	7	7
E-I	-18.1913	-1.0703	-94.5609	-113.8225	53	7	5	5051	0	15	12
I-Z	-13.7406	-12.7472	-123.43	-149.9178	45	18	9	5509	0	9	2

Interface residues

• C-E: ALA139C, ALA139E, ALA247C, ALA247E, ARG188C, ARG188E, ARG312C, ARG312E, ARG331C, ARG331E, ARG76C, ARG76E, ASN225C, ASN225E, ASN245C, ASN245E, ASN311C, ASN311E, ASP194C, ASP194E, CYS242C, CYS242E, GLN189C, GLN189E, GLN248C, GLN248E, GLU313C, GLU313E, GLY137C, GLY64E, HIS198C, ILE241C, ILE241E, LEU191C, LEU191E, LEU197C, LEU197E, LEU243C, LEU243E, LYS138C, LYS138E, LYS195C, LYS195E, LYS226C, LYS226E, LYS77C, LYS77E, MET192C, MET192E, PHE190C, PHE190E, PHE244C, PHE244E, PHE61C, PHE61E, PHE75C, PHE75E, PRO196C, PRO196E, SER193C, SER193E, SER341C, THR187C, THR187E, THR224C, THR224E, THR246C, THR246E, THR74C, THR74E, TYR63C, TYR63E, VAL343C, VAL343E
• C-I: ARG285C, ASP135C, GLN241I, GLU134C, GLY132C, LYS138C, LYS245I, LYS246I, MET206I, PHE243I, PRO133C, PRO242I, PRO244I, THR136C, THR289I
• E-I: ALA247I, ALA339E, ARG188I, ARG331E, ASP187I, ASP259E, ASP337E, ASP342E, GLN182I, GLN192I, GLU195I, GLU232I, GLU257E, GLY234I, GLY332E, GLY333E, GLY336E, HIS229I, ILE194I, ILE230I, ILE231I, LEU165I, LEU166I, LEU183I, LEU215I, LEU228I, LEU334E, LEU335E, LEU338E, LYS189I, LYS229E, LYS230E, LYS232E, LYS245I, LYS246I, PHE201I, PHE216I, PHE218I, PRO193I, SER185I, SER191I, SER330E, SER340E, SER341E, THR214I, THR235I, TRP164I, TYR184I, VAL186I, VAL190I, VAL233I, VAL328E, VAL329E
• I-Z: ALA101I, ALA378Z, ALA48I, ALA68I, ALA71I, ALA81I, ALA84I, ARG41I, ARG63I, ARG64I, ASN372Z, ASN92I, ASP377Z, ASP69I, GLN47I, GLN49I, GLN89I, GLU375Z, GLU94I, GLY85I, ILE374Z, ILE52I, ILE62I, ILE66I, ILE80I, ILE90I, ILE93I, LEU373Z, LEU376Z, LEU82I, LEU88I, LYS83I, LYS86I, LYS96I, LYS98I, MET95I, PHE91I, PRO65I, SER67I, SER70I, SER97I, THR371Z, THR87I, TRP111I, VAL50I