3GCF

terminal oxygenase of carbazole 1,9a-dioxygenase from nocardioides aromaticivorans ic177

• Total interactions analyzed: 105
• Total true interactions: 27
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 115
  • Norm. En. per Res.: -4.6775
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.7384	-121.2167	-381.104	-542.0592	121	13	10	15217	8	41	35
A-C	-33.2235	-117.1416	-375.425	-525.7901	121	11	10	15180	7	40	35
A-D	-4.8196	-3.8722	-98.6317	-107.3235	59	4	0	4030	3	61	59
B-C	-36.8907	-102.4317	-382.733	-522.0554	119	10	11	15403	6	40	36
B-E	-11.1759	-0.7257	-100.469	-112.3706	62	4	0	4285	3	60	59
C-F	-4.4492	17.5195	-92.6578	-79.5875	59	5	0	3962	3	59	59
D-E	-41.1627	-113.3125	-375.344	-529.8193	118	11	10	15202	6	39	35
D-F	-35.7631	-111.3414	-370.539	-517.6435	117	13	11	15241	6	40	35
D-G	-4.0349	-22.1864	-107.594	-133.8153	62	3	0	4241	3	59	60
E-F	-38.5879	-110.3029	-369.541	-518.4318	116	13	11	15233	6	39	35
E-H	0.0	9.7634	-99.5745	-89.8111	60	4	0	4019	4	59	62
F-I	0.0	-1.4835	-99.1184	-100.6019	61	6	0	4093	4	58	61
G-H	-42.619	-119.8442	-375.454	-537.9171	115	17	11	15344	7	40	35
G-I	-40.5001	-117.7009	-373.311	-531.512	118	16	10	15372	7	40	34
G-J	-4.7762	9.9992	-103.145	-97.922	63	4	0	4164	2	60	59
H-I	-41.2537	-97.3353	-377.233	-515.822	114	18	10	15303	7	39	35
H-K	-3.9799	8.9008	-96.8999	-91.979	60	3	0	4080	3	61	59
I-L	-4.4208	20.1394	-95.2896	-79.571	61	5	0	3952	2	61	59
J-K	-38.6795	-115.4147	-372.997	-527.0912	115	17	9	15287	6	40	34
J-L	-37.1655	-118.4335	-373.071	-528.67	117	18	12	15400	6	40	34
J-M	-6.1171	-4.5783	-109.656	-120.3514	62	5	0	4351	3	60	64
K-L	-41.4023	-122.5633	-373.473	-537.4386	117	15	10	15541	8	40	34
K-N	-11.3739	-16.1218	-98.5269	-126.0226	61	5	0	4166	3	60	63
L-O	-8.1344	-13.8252	-105.315	-127.2746	61	7	0	4430	3	59	63
M-N	-56.2615	-115.5879	-380.408	-552.2575	119	15	11	15575	6	41	36
M-O	-52.3465	-110.6095	-382.023	-544.979	119	13	10	15569	6	41	36
N-O	-47.1537	-110.3009	-379.542	-536.9966	120	12	11	15551	6	41	36

Interface residues

• A-B: ALA243A, ALA340A, ALA343A, ALA76B, ALA91B, ARG109B, ARG178A, ARG194A, ARG341A, ARG351A, ARG370A, ARG78B, ASN183A, ASN195A, ASP104B, ASP112B, ASP186A, ASP246A, ASP336A, ASP337A, ASP363A, CYS75B, CYS88B, CYS96B, GLN344A, GLN345A, GLN358A, GLU182A, GLU242A, GLU248A, GLU295B, GLU342A, GLU346A, GLU357A, GLU57B, GLU85B, GLY100B, GLY118B, GLY126B, GLY180A, GLY184A, GLY209A, GLY247A, GLY353A, GLY56B, GLY74B, GLY79B, GLY92B, HIS189A, HIS193A, HIS77B, HIS99B, ILE122B, ILE125B, ILE127B, ILE190A, ILE366A, LEU110B, LEU114B, LEU179A, LEU245A, LEU251A, LEU29B, LEU359A, LEU87B, LYS124B, LYS356A, LYS58B, LYS84B, LYS90B, MET192A, MET238A, MET364A, PHE185A, PHE191A, PHE210A, PHE241A, PHE347A, PHE360A, PHE82B, PHE89B, PRO117B, PRO120B, PRO207A, PRO212A, PRO239A, PRO361A, PRO362A, PRO81B, PRO86B, SER116B, SER119B, SER294B, SER95B, THR102B, THR115B, THR187A, THR188A, THR244A, THR249A, THR53B, THR93B, TRP101B, TRP339A, TRP354A, TRP97B, TYR103B, TYR208A, TYR24A, TYR348A, TYR98B, VAL111B, VAL113B, VAL121B, VAL181A, VAL211A, VAL240A, VAL250A, VAL367A, VAL80B, VAL94B
• A-C: ALA243C, ALA340C, ALA343C, ALA76A, ALA91A, ARG109A, ARG178C, ARG194C, ARG341C, ARG351C, ARG370C, ARG78A, ASN183C, ASN195C, ASP104A, ASP112A, ASP186C, ASP246C, ASP336C, ASP337C, ASP363C, CYS75A, CYS88A, CYS96A, GLN344C, GLN345C, GLN358C, GLU182C, GLU242C, GLU248C, GLU295A, GLU342C, GLU346C, GLU357C, GLU57A, GLU85A, GLY100A, GLY118A, GLY126A, GLY180C, GLY184C, GLY209C, GLY247C, GLY353C, GLY56A, GLY74A, GLY79A, GLY92A, HIS189C, HIS193C, HIS77A, HIS99A, ILE122A, ILE125A, ILE127A, ILE190C, ILE366C, LEU110A, LEU114A, LEU179C, LEU245C, LEU251C, LEU29A, LEU359C, LEU87A, LYS124A, LYS356C, LYS58A, LYS84A, LYS90A, MET192C, MET238C, MET364C, PHE185C, PHE191C, PHE210C, PHE241C, PHE347C, PHE360C, PHE82A, PHE89A, PRO117A, PRO120A, PRO207C, PRO212C, PRO239C, PRO361C, PRO362C, PRO81A, PRO86A, SER116A, SER119A, SER294A, SER95A, THR102A, THR115A, THR187C, THR188C, THR244C, THR249C, THR53A, THR93A, TRP101A, TRP339C, TRP354C, TRP97A, TYR103A, TYR208C, TYR24C, TYR348C, TYR98A, VAL111A, VAL113A, VAL121A, VAL181C, VAL211C, VAL240C, VAL250C, VAL367C, VAL80A, VAL94A
• A-D: ALA329A, ALA373D, ARG203A, ARG23D, ARG324A, ARG326A, ARG376D, ARG378D, ASN195A, ASN202A, ASN224D, ASN33D, ASP145D, ASP222D, ASP281A, ASP327A, ASP328A, ASP32D, ASP336A, GLN18D, GLU146D, GLU147D, GLU223D, GLU258A, GLU26D, GLU318A, GLU320A, GLU322A, GLU323A, GLU375D, GLY201A, GLY332A, GLY377D, GLY379D, HIS149D, HIS331A, HIS34D, LEU372D, LYS20D, LYS227D, LYS260A, LYS315A, PHE142D, PHE321A, PRO197A, PRO22D, SER196A, SER200A, SER374D, THR371D, TRP198A, TRP21D, TRP225D, TRP325A, VAL199A, VAL19D, VAL220D, VAL319A, VAL380D
• B-C: ALA243B, ALA340B, ALA343B, ALA72C, ALA76C, ALA91C, ARG109C, ARG178B, ARG194B, ARG341B, ARG351B, ARG370B, ARG78C, ASN183B, ASN195B, ASP104C, ASP112C, ASP186B, ASP246B, ASP336B, ASP337B, ASP363B, ASP73C, CYS75C, CYS88C, CYS96C, GLN344B, GLN345B, GLN358B, GLU182B, GLU242B, GLU248B, GLU342B, GLU346B, GLU357B, GLU57C, GLU85C, GLY100C, GLY118C, GLY126C, GLY180B, GLY184B, GLY209B, GLY247B, GLY353B, GLY56C, GLY74C, GLY79C, GLY92C, HIS189B, HIS193B, HIS77C, HIS99C, ILE122C, ILE125C, ILE127C, ILE190B, ILE366B, LEU110C, LEU114C, LEU179B, LEU245B, LEU251B, LEU359B, LEU87C, LYS124C, LYS356B, LYS58C, LYS84C, LYS90C, MET192B, MET238B, PHE185B, PHE191B, PHE210B, PHE241B, PHE347B, PHE360B, PHE82C, PHE89C, PRO117C, PRO120C, PRO207B, PRO212B, PRO239B, PRO361B, PRO362B, PRO81C, PRO86C, SER116C, SER119C, SER83C, SER95C, THR102C, THR115C, THR187B, THR188B, THR244B, THR249B, THR93C, TRP101C, TRP339B, TRP354B, TRP97C, TYR103C, TYR208B, TYR24B, TYR348B, TYR98C, VAL111C, VAL113C, VAL121C, VAL181B, VAL211B, VAL240B, VAL250B, VAL367B, VAL80C, VAL94C
• B-E: ALA329B, ALA373E, ARG203B, ARG23E, ARG324B, ARG326B, ARG376E, ARG378E, ASN195B, ASN202B, ASN224E, ASN33E, ASP145E, ASP222E, ASP281B, ASP327B, ASP328B, ASP32E, ASP336B, GLN18E, GLU146E, GLU147E, GLU153E, GLU223E, GLU258B, GLU26E, GLU318B, GLU320B, GLU322B, GLU323B, GLU375E, GLY201B, GLY332B, GLY377E, GLY379E, HIS149E, HIS331B, HIS34E, LEU372E, LYS20E, LYS227E, LYS260B, LYS315B, PHE142E, PHE321B, PRO148E, PRO197B, PRO22E, SER16E, SER196B, SER200B, SER374E, THR371E, TRP198B, TRP21E, TRP225E, TRP325B, VAL199B, VAL19E, VAL220E, VAL319B, VAL380E
• C-F: ALA329C, ALA373F, ARG203C, ARG23F, ARG324C, ARG326C, ARG376F, ARG378F, ASN195C, ASN202C, ASN224F, ASN33F, ASP145F, ASP222F, ASP281C, ASP327C, ASP328C, ASP32F, GLN18F, GLU146F, GLU147F, GLU223F, GLU258C, GLU26F, GLU318C, GLU320C, GLU322C, GLU323C, GLU375F, GLY201C, GLY332C, GLY377F, GLY379F, HIS149F, HIS331C, HIS34F, LEU372F, LYS20F, LYS227F, LYS260C, LYS315C, PHE142F, PHE321C, PRO197C, PRO22F, SER16F, SER196C, SER200C, SER374F, THR371F, TRP198C, TRP21F, TRP225F, TRP325C, VAL199C, VAL19F, VAL220F, VAL319C, VAL380F
• D-E: ALA243D, ALA340D, ALA343D, ALA76E, ALA91E, ARG109E, ARG178D, ARG194D, ARG341D, ARG351D, ARG370D, ARG78E, ASN183D, ASN195D, ASP104E, ASP112E, ASP186D, ASP246D, ASP336D, ASP337D, ASP363D, CYS75E, CYS88E, CYS96E, GLN344D, GLN345D, GLN358D, GLU182D, GLU242D, GLU248D, GLU295E, GLU342D, GLU346D, GLU357D, GLU85E, GLY100E, GLY118E, GLY126E, GLY180D, GLY184D, GLY209D, GLY247D, GLY353D, GLY56E, GLY74E, GLY79E, HIS189D, HIS193D, HIS77E, HIS99E, ILE122E, ILE125E, ILE127E, ILE190D, ILE366D, LEU110E, LEU114E, LEU179D, LEU245D, LEU251D, LEU29E, LEU359D, LEU87E, LYS124E, LYS356D, LYS58E, LYS84E, LYS90E, MET192D, MET238D, PHE185D, PHE191D, PHE210D, PHE241D, PHE347D, PHE360D, PHE82E, PHE89E, PRO117E, PRO120E, PRO207D, PRO212D, PRO239D, PRO361D, PRO362D, PRO81E, PRO86E, SER116E, SER119E, SER252D, SER294E, SER95E, THR102E, THR115E, THR187D, THR188D, THR244D, THR249D, THR93E, TRP101E, TRP339D, TRP354D, TRP97E, TYR103E, TYR208D, TYR24D, TYR348D, TYR98E, VAL111E, VAL113E, VAL121E, VAL181D, VAL211D, VAL240D, VAL250D, VAL367D, VAL80E, VAL94E
• D-F: ALA243F, ALA340F, ALA343F, ALA76D, ALA91D, ARG109D, ARG178F, ARG194F, ARG341F, ARG351F, ARG370F, ARG78D, ASN183F, ASN195F, ASP104D, ASP112D, ASP186F, ASP246F, ASP336F, ASP337F, ASP363F, CYS75D, CYS88D, CYS96D, GLN344F, GLN345F, GLN358F, GLU182F, GLU242F, GLU248F, GLU295D, GLU342F, GLU346F, GLU357F, GLU57D, GLU85D, GLY100D, GLY118D, GLY126D, GLY180F, GLY184F, GLY209F, GLY247F, GLY353F, GLY56D, GLY74D, GLY79D, HIS189F, HIS193F, HIS77D, HIS99D, ILE122D, ILE125D, ILE127D, ILE190F, ILE366F, LEU110D, LEU114D, LEU179F, LEU245F, LEU251F, LEU359F, LEU87D, LYS124D, LYS356F, LYS58D, LYS84D, LYS90D, MET192F, MET238F, PHE185F, PHE191F, PHE210F, PHE347F, PHE360F, PHE82D, PHE89D, PRO117D, PRO120D, PRO207F, PRO212F, PRO239F, PRO361F, PRO362F, PRO81D, PRO86D, SER116D, SER119D, SER252F, SER294D, SER95D, THR102D, THR115D, THR187F, THR188F, THR244F, THR249F, THR93D, TRP101D, TRP339F, TRP354F, TRP97D, TYR103D, TYR208F, TYR24F, TYR348F, TYR98D, VAL111D, VAL113D, VAL121D, VAL181F, VAL211F, VAL240F, VAL250F, VAL367F, VAL80D, VAL94D
• D-G: ALA329D, ALA373G, ARG203D, ARG23G, ARG324D, ARG326D, ARG376G, ARG378G, ASN195D, ASN202D, ASN224G, ASN33G, ASP145G, ASP222G, ASP281D, ASP327D, ASP328D, ASP32G, ASP336D, GLN18G, GLU146G, GLU147G, GLU223G, GLU258D, GLU26G, GLU318D, GLU320D, GLU322D, GLU323D, GLU375G, GLY201D, GLY332D, GLY377G, GLY379G, HIS149G, HIS331D, HIS34G, LEU372G, LYS20G, LYS227G, LYS260D, LYS315D, PHE142G, PHE321D, PRO148G, PRO197D, PRO22G, SER16G, SER196D, SER200D, SER374G, THR371G, TRP198D, TRP21G, TRP225G, TRP325D, TYR221G, VAL199D, VAL19G, VAL220G, VAL319D, VAL380G
• E-F: ALA243E, ALA340E, ALA343E, ALA76F, ALA91F, ARG109F, ARG178E, ARG194E, ARG341E, ARG351E, ARG370E, ARG78F, ASN183E, ASN195E, ASP104F, ASP112F, ASP186E, ASP246E, ASP336E, ASP337E, ASP363E, CYS75F, CYS88F, CYS96F, GLN344E, GLN345E, GLN358E, GLU182E, GLU242E, GLU248E, GLU295F, GLU342E, GLU346E, GLU357E, GLU57F, GLU85F, GLY100F, GLY118F, GLY126F, GLY180E, GLY184E, GLY209E, GLY247E, GLY353E, GLY56F, GLY74F, GLY79F, HIS189E, HIS193E, HIS77F, HIS99F, ILE122F, ILE125F, ILE127F, ILE190E, ILE366E, LEU110F, LEU114F, LEU179E, LEU245E, LEU251E, LEU359E, LEU87F, LYS124F, LYS356E, LYS58F, LYS84F, LYS90F, MET192E, MET238E, PHE185E, PHE191E, PHE210E, PHE241E, PHE347E, PHE360E, PHE82F, PHE89F, PRO117F, PRO120F, PRO207E, PRO212E, PRO239E, PRO361E, PRO362E, PRO81F, PRO86F, SER116F, SER119F, SER95F, THR102F, THR115F, THR187E, THR188E, THR244E, THR249E, THR93F, TRP101F, TRP339E, TRP354E, TRP97F, TYR103F, TYR208E, TYR24E, TYR348E, TYR98F, VAL111F, VAL113F, VAL121F, VAL181E, VAL211E, VAL240E, VAL250E, VAL367E, VAL80F, VAL94F
• E-H: ALA329E, ALA373H, ARG203E, ARG23H, ARG324E, ARG326E, ARG376H, ARG378H, ASN195E, ASN202E, ASN224H, ASN33H, ASP145H, ASP222H, ASP281E, ASP327E, ASP328E, ASP32H, ASP336E, GLN18H, GLU146H, GLU147H, GLU223H, GLU258E, GLU26H, GLU318E, GLU320E, GLU322E, GLU323E, GLU375H, GLY201E, GLY332E, GLY377H, GLY379H, HIS149H, HIS331E, HIS34H, LEU372H, LYS20H, LYS227H, LYS260E, LYS315E, PHE142H, PHE321E, PRO148H, PRO197E, PRO22H, SER16H, SER196E, SER200E, SER374H, THR371H, TRP198E, TRP21H, TRP225H, TRP325E, VAL199E, VAL19H, VAL319E, VAL380H
• F-I: ALA150I, ALA17I, ALA329F, ALA373I, ARG203F, ARG23I, ARG324F, ARG326F, ARG376I, ARG378I, ASN195F, ASN202F, ASN224I, ASN33I, ASP145I, ASP222I, ASP281F, ASP327F, ASP328F, ASP32I, ASP336F, GLN18I, GLU146I, GLU147I, GLU223I, GLU258F, GLU26I, GLU318F, GLU320F, GLU322F, GLU323F, GLU375I, GLY201F, GLY332F, GLY377I, GLY379I, HIS149I, HIS331F, HIS34I, LEU372I, LYS20I, LYS227I, LYS260F, LYS315F, PHE142I, PHE321F, PRO148I, PRO197F, PRO22I, SER196F, SER200F, SER374I, THR371I, TRP198F, TRP21I, TRP225I, TRP325F, VAL199F, VAL19I, VAL319F, VAL380I
• G-H: ALA243G, ALA340G, ALA343G, ALA76H, ALA91H, ARG109H, ARG178G, ARG194G, ARG341G, ARG351G, ARG370G, ARG78H, ASN183G, ASN195G, ASP104H, ASP112H, ASP186G, ASP246G, ASP336G, ASP337G, ASP363G, CYS75H, CYS88H, CYS96H, GLN344G, GLN345G, GLN358G, GLU182G, GLU242G, GLU248G, GLU342G, GLU346G, GLU357G, GLU85H, GLY100H, GLY118H, GLY126H, GLY180G, GLY184G, GLY209G, GLY247G, GLY353G, GLY56H, GLY74H, GLY79H, HIS189G, HIS193G, HIS77H, HIS99H, ILE122H, ILE125H, ILE127H, ILE190G, ILE366G, LEU110H, LEU114H, LEU179G, LEU245G, LEU251G, LEU359G, LEU87H, LYS124H, LYS356G, LYS58H, LYS84H, LYS90H, MET192G, MET238G, MET364G, PHE185G, PHE191G, PHE210G, PHE241G, PHE347G, PHE360G, PHE82H, PHE89H, PRO117H, PRO120H, PRO207G, PRO212G, PRO239G, PRO361G, PRO362G, PRO81H, PRO86H, SER116H, SER119H, SER95H, THR102H, THR115H, THR187G, THR188G, THR244G, THR249G, THR93H, TRP101H, TRP339G, TRP354G, TRP97H, TYR103H, TYR208G, TYR24G, TYR348G, TYR98H, VAL111H, VAL113H, VAL121H, VAL181G, VAL211G, VAL240G, VAL250G, VAL367G, VAL80H, VAL94H
• G-I: ALA243I, ALA340I, ALA343I, ALA72G, ALA76G, ALA91G, ARG109G, ARG178I, ARG194I, ARG341I, ARG351I, ARG370I, ARG78G, ASN183I, ASN195I, ASP104G, ASP112G, ASP186I, ASP246I, ASP336I, ASP337I, ASP363I, CYS75G, CYS88G, CYS96G, GLN344I, GLN345I, GLN358I, GLU182I, GLU242I, GLU248I, GLU342I, GLU346I, GLU357I, GLU57G, GLU85G, GLY100G, GLY118G, GLY126G, GLY180I, GLY184I, GLY209I, GLY247I, GLY353I, GLY56G, GLY74G, GLY79G, HIS189I, HIS193I, HIS77G, HIS99G, ILE122G, ILE125G, ILE127G, ILE190I, ILE366I, LEU110G, LEU114G, LEU179I, LEU245I, LEU251I, LEU359I, LEU87G, LYS124G, LYS356I, LYS58G, LYS84G, LYS90G, MET192I, MET238I, MET364I, PHE185I, PHE191I, PHE210I, PHE241I, PHE347I, PHE360I, PHE82G, PHE89G, PRO117G, PRO120G, PRO207I, PRO212I, PRO239I, PRO361I, PRO362I, PRO81G, PRO86G, SER116G, SER119G, SER83G, SER95G, THR102G, THR115G, THR187I, THR188I, THR244I, THR249I, THR93G, TRP101G, TRP339I, TRP354I, TRP97G, TYR103G, TYR208I, TYR24I, TYR348I, TYR98G, VAL111G, VAL113G, VAL121G, VAL181I, VAL211I, VAL240I, VAL250I, VAL367I, VAL80G, VAL94G
• G-J: ALA17J, ALA329G, ALA373J, ARG203G, ARG23J, ARG324G, ARG326G, ARG376J, ARG378J, ASN195G, ASN202G, ASN224J, ASN33J, ASP145J, ASP222J, ASP281G, ASP327G, ASP328G, ASP32J, ASP336G, GLN18J, GLU146J, GLU147J, GLU153J, GLU223J, GLU258G, GLU26J, GLU318G, GLU320G, GLU322G, GLU323G, GLU375J, GLY201G, GLY332G, GLY377J, GLY379J, HIS149J, HIS331G, HIS34J, LEU372J, LYS20J, LYS227J, LYS260G, LYS315G, PHE142J, PHE321G, PRO148J, PRO197G, PRO22J, SER16J, SER196G, SER200G, SER374J, THR371J, TRP198G, TRP21J, TRP225J, TRP325G, VAL199G, VAL19J, VAL220J, VAL319G, VAL380J
• H-I: ALA243H, ALA340H, ALA343H, ALA76I, ALA91I, ARG109I, ARG178H, ARG194H, ARG341H, ARG351H, ARG370H, ARG78I, ASN183H, ASN195H, ASP104I, ASP112I, ASP186H, ASP246H, ASP336H, ASP337H, ASP363H, CYS75I, CYS88I, CYS96I, GLN344H, GLN345H, GLN358H, GLU182H, GLU242H, GLU248H, GLU342H, GLU346H, GLU357H, GLU85I, GLY100I, GLY118I, GLY126I, GLY180H, GLY184H, GLY209H, GLY247H, GLY353H, GLY56I, GLY74I, GLY79I, HIS189H, HIS193H, HIS77I, HIS99I, ILE122I, ILE125I, ILE127I, ILE190H, ILE366H, LEU110I, LEU114I, LEU179H, LEU245H, LEU251H, LEU359H, LEU87I, LYS124I, LYS356H, LYS58I, LYS84I, LYS90I, MET192H, MET238H, PHE185H, PHE191H, PHE210H, PHE241H, PHE347H, PHE360H, PHE82I, PHE89I, PRO117I, PRO120I, PRO207H, PRO212H, PRO239H, PRO361H, PRO362H, PRO81I, PRO86I, SER116I, SER119I, SER95I, THR102I, THR115I, THR187H, THR188H, THR244H, THR249H, THR93I, TRP101I, TRP339H, TRP354H, TRP97I, TYR103I, TYR208H, TYR24H, TYR348H, TYR98I, VAL111I, VAL113I, VAL121I, VAL181H, VAL211H, VAL240H, VAL250H, VAL367H, VAL80I, VAL94I
• H-K: ALA17K, ALA329H, ALA373K, ARG203H, ARG23K, ARG324H, ARG326H, ARG376K, ARG378K, ASN195H, ASN202H, ASN224K, ASN33K, ASP145K, ASP222K, ASP327H, ASP328H, ASP32K, ASP336H, GLN18K, GLU146K, GLU147K, GLU153K, GLU223K, GLU26K, GLU318H, GLU320H, GLU322H, GLU323H, GLU375K, GLY201H, GLY332H, GLY377K, GLY379K, HIS149K, HIS331H, HIS34K, LEU372K, LYS20K, LYS227K, LYS260H, LYS315H, PHE142K, PHE321H, PRO148K, PRO197H, PRO22K, SER196H, SER200H, SER374K, THR371K, TRP198H, TRP21K, TRP225K, TRP325H, VAL199H, VAL19K, VAL220K, VAL319H, VAL380K
• I-L: ALA329I, ALA373L, ARG203I, ARG23L, ARG324I, ARG326I, ARG376L, ARG378L, ASN195I, ASN202I, ASN224L, ASN33L, ASP145L, ASP222L, ASP281I, ASP327I, ASP328I, ASP32L, GLN18L, GLU146L, GLU147L, GLU153L, GLU223L, GLU258I, GLU26L, GLU318I, GLU320I, GLU322I, GLU323I, GLU375L, GLY201I, GLY332I, GLY377L, GLY379L, HIS149L, HIS331I, HIS34L, LEU372L, LYS20L, LYS227L, LYS260I, LYS315I, PHE142L, PHE321I, PRO148L, PRO197I, PRO22L, SER16L, SER196I, SER200I, SER374L, THR371L, TRP198I, TRP21L, TRP225L, TRP325I, VAL199I, VAL19L, VAL220L, VAL319I, VAL380L
• J-K: ALA243J, ALA340J, ALA343J, ALA76K, ALA91K, ARG109K, ARG178J, ARG194J, ARG341J, ARG351J, ARG370J, ARG78K, ASN183J, ASN195J, ASP104K, ASP112K, ASP186J, ASP246J, ASP336J, ASP337J, ASP363J, CYS75K, CYS88K, CYS96K, GLN344J, GLN345J, GLN358J, GLU182J, GLU242J, GLU248J, GLU342J, GLU346J, GLU357J, GLU57K, GLU85K, GLY100K, GLY118K, GLY126K, GLY180J, GLY184J, GLY209J, GLY247J, GLY353J, GLY56K, GLY74K, GLY79K, HIS189J, HIS193J, HIS77K, HIS99K, ILE122K, ILE125K, ILE127K, ILE190J, ILE366J, LEU110K, LEU114K, LEU179J, LEU245J, LEU251J, LEU359J, LEU87K, LYS124K, LYS356J, LYS58K, LYS84K, LYS90K, MET192J, MET238J, PHE185J, PHE191J, PHE210J, PHE241J, PHE347J, PHE360J, PHE82K, PHE89K, PRO117K, PRO120K, PRO207J, PRO212J, PRO239J, PRO361J, PRO362J, PRO81K, PRO86K, SER116K, SER119K, SER95K, THR102K, THR115K, THR187J, THR188J, THR244J, THR249J, THR93K, TRP101K, TRP339J, TRP354J, TRP97K, TYR103K, TYR208J, TYR24J, TYR348J, TYR98K, VAL111K, VAL113K, VAL121K, VAL181J, VAL211J, VAL240J, VAL250J, VAL367J, VAL80K, VAL94K
• J-L: ALA243L, ALA340L, ALA343L, ALA72J, ALA76J, ALA91J, ARG109J, ARG178L, ARG194L, ARG341L, ARG351L, ARG370L, ARG78J, ASN183L, ASN195L, ASP104J, ASP112J, ASP186L, ASP246L, ASP336L, ASP337L, ASP363L, ASP73J, CYS75J, CYS88J, CYS96J, GLN344L, GLN345L, GLN358L, GLU182L, GLU242L, GLU248L, GLU342L, GLU346L, GLU357L, GLU57J, GLU85J, GLY100J, GLY118J, GLY126J, GLY180L, GLY184L, GLY209L, GLY247L, GLY353L, GLY56J, GLY74J, GLY79J, HIS189L, HIS193L, HIS77J, HIS99J, ILE122J, ILE125J, ILE127J, ILE190L, ILE366L, LEU110J, LEU114J, LEU179L, LEU245L, LEU251L, LEU359L, LEU87J, LYS124J, LYS356L, LYS58J, LYS84J, LYS90J, MET192L, MET238L, PHE185L, PHE191L, PHE210L, PHE241L, PHE347L, PHE360L, PHE82J, PHE89J, PRO117J, PRO120J, PRO207L, PRO212L, PRO239L, PRO361L, PRO362L, PRO81J, PRO86J, SER116J, SER119J, SER95J, THR102J, THR115J, THR187L, THR188L, THR244L, THR249L, THR93J, TRP101J, TRP339L, TRP354L, TRP97J, TYR103J, TYR208L, TYR24L, TYR348L, TYR98J, VAL111J, VAL113J, VAL121J, VAL181L, VAL211L, VAL240L, VAL250L, VAL367L, VAL80J, VAL94J
• J-M: ALA329J, ALA373M, ARG203J, ARG23M, ARG324J, ARG326J, ARG376M, ARG378M, ASN195J, ASN202J, ASN224M, ASN33M, ASP145M, ASP222M, ASP281J, ASP327J, ASP328J, ASP32M, ASP336J, GLN18M, GLU146M, GLU147M, GLU223M, GLU258J, GLU26M, GLU312J, GLU318J, GLU320J, GLU322J, GLU323J, GLU375M, GLY201J, GLY332J, GLY377M, GLY379M, HIS149M, HIS331J, HIS34M, LEU372M, LYS20M, LYS227M, LYS260J, LYS315J, PHE142M, PHE321J, PRO148M, PRO197J, PRO22M, SER196J, SER200J, SER374M, THR316J, THR371M, TRP198J, TRP21M, TRP225M, TRP325J, VAL199J, VAL19M, VAL220M, VAL319J, VAL380M
• K-L: ALA243K, ALA340K, ALA343K, ALA72L, ALA76L, ALA91L, ARG109L, ARG178K, ARG194K, ARG341K, ARG351K, ARG370K, ARG78L, ASN183K, ASN195K, ASP112L, ASP186K, ASP246K, ASP336K, ASP337K, ASP363K, ASP73L, CYS75L, CYS88L, CYS96L, GLN344K, GLN345K, GLN358K, GLU182K, GLU242K, GLU248K, GLU342K, GLU346K, GLU357K, GLU57L, GLU85L, GLY100L, GLY118L, GLY126L, GLY180K, GLY184K, GLY209K, GLY247K, GLY353K, GLY56L, GLY74L, GLY79L, HIS189K, HIS193K, HIS77L, HIS99L, ILE122L, ILE125L, ILE127L, ILE190K, ILE366K, LEU110L, LEU114L, LEU179K, LEU245K, LEU251K, LEU359K, LEU87L, LYS124L, LYS356K, LYS58L, LYS84L, LYS90L, MET192K, MET238K, PHE185K, PHE191K, PHE210K, PHE241K, PHE347K, PHE360K, PHE82L, PHE89L, PRO117L, PRO120L, PRO207K, PRO212K, PRO239K, PRO361K, PRO362K, PRO81L, PRO86L, SER116L, SER119L, SER83L, SER95L, THR102L, THR115L, THR187K, THR188K, THR244K, THR249K, THR93L, TRP101L, TRP339K, TRP354K, TRP97L, TYR103L, TYR208K, TYR24K, TYR348K, TYR98L, VAL111L, VAL113L, VAL121L, VAL181K, VAL211K, VAL240K, VAL250K, VAL367K, VAL80L, VAL94L
• K-N: ALA329K, ALA373N, ARG203K, ARG23N, ARG324K, ARG326K, ARG376N, ARG378N, ASN195K, ASN202K, ASN224N, ASN33N, ASP145N, ASP222N, ASP281K, ASP327K, ASP328K, ASP32N, ASP336K, GLN18N, GLU146N, GLU147N, GLU223N, GLU258K, GLU26N, GLU318K, GLU320K, GLU322K, GLU323K, GLU375N, GLY201K, GLY332K, GLY377N, GLY379N, HIS149N, HIS331K, HIS34N, LEU372N, LYS20N, LYS227N, LYS260K, LYS315K, PHE142N, PHE321K, PRO148N, PRO197K, PRO22N, SER16N, SER196K, SER200K, SER374N, THR316K, THR371N, TRP198K, TRP21N, TRP225N, TRP325K, VAL199K, VAL19N, VAL319K, VAL380N
• L-O: ALA329L, ALA373O, ARG203L, ARG23O, ARG324L, ARG326L, ARG376O, ARG378O, ASN195L, ASN202L, ASN224O, ASN33O, ASP145O, ASP222O, ASP281L, ASP327L, ASP328L, ASP32O, ASP336L, GLN18O, GLU146O, GLU147O, GLU223O, GLU258L, GLU26O, GLU318L, GLU320L, GLU322L, GLU323L, GLU375O, GLY201L, GLY332L, GLY377O, GLY379O, HIS149O, HIS331L, HIS34O, LEU372O, LYS20O, LYS227O, LYS260L, LYS315L, PHE142O, PHE321L, PRO148O, PRO197L, PRO22O, SER16O, SER196L, SER200L, SER374O, THR371O, TRP198L, TRP21O, TRP225O, TRP325L, VAL199L, VAL19O, VAL220O, VAL319L, VAL380O
• M-N: ALA243M, ALA340M, ALA343M, ALA72N, ALA76N, ALA91N, ARG109N, ARG178M, ARG194M, ARG215M, ARG341M, ARG351M, ARG370M, ARG78N, ASN183M, ASN195M, ASP104N, ASP112N, ASP186M, ASP246M, ASP336M, ASP337M, ASP363M, ASP73N, CYS75N, CYS88N, CYS96N, GLN344M, GLN345M, GLN358M, GLU182M, GLU242M, GLU248M, GLU342M, GLU346M, GLU357M, GLU57N, GLU85N, GLY100N, GLY118N, GLY126N, GLY180M, GLY184M, GLY209M, GLY247M, GLY353M, GLY56N, GLY74N, GLY79N, HIS189M, HIS193M, HIS77N, HIS99N, ILE122N, ILE125N, ILE127N, ILE190M, ILE366M, LEU110N, LEU114N, LEU179M, LEU245M, LEU251M, LEU359M, LEU87N, LYS124N, LYS356M, LYS58N, LYS84N, LYS90N, MET192M, MET238M, PHE185M, PHE191M, PHE210M, PHE241M, PHE347M, PHE360M, PHE82N, PHE89N, PRO117N, PRO120N, PRO207M, PRO212M, PRO239M, PRO361M, PRO362M, PRO81N, PRO86N, SER116N, SER119N, SER83N, SER95N, THR102N, THR115N, THR187M, THR188M, THR244M, THR249M, THR93N, TRP101N, TRP339M, TRP354M, TRP97N, TYR103N, TYR208M, TYR24M, TYR348M, TYR98N, VAL111N, VAL113N, VAL121N, VAL181M, VAL211M, VAL240M, VAL250M, VAL367M, VAL80N, VAL94N
• M-O: ALA243O, ALA340O, ALA343O, ALA72M, ALA76M, ALA91M, ARG109M, ARG178O, ARG194O, ARG215O, ARG341O, ARG351O, ARG370O, ARG78M, ASN183O, ASN195O, ASP104M, ASP112M, ASP186O, ASP246O, ASP336O, ASP337O, ASP363O, ASP73M, CYS75M, CYS88M, CYS96M, GLN344O, GLN345O, GLN358O, GLU182O, GLU242O, GLU248O, GLU342O, GLU346O, GLU357O, GLU57M, GLU85M, GLY100M, GLY118M, GLY126M, GLY180O, GLY184O, GLY209O, GLY247O, GLY353O, GLY56M, GLY74M, GLY79M, HIS189O, HIS193O, HIS77M, HIS99M, ILE122M, ILE125M, ILE127M, ILE190O, ILE366O, LEU110M, LEU114M, LEU179O, LEU245O, LEU251O, LEU359O, LEU87M, LYS124M, LYS356O, LYS58M, LYS84M, LYS90M, MET192O, MET238O, PHE185O, PHE191O, PHE210O, PHE241O, PHE347O, PHE360O, PHE82M, PHE89M, PRO117M, PRO120M, PRO207O, PRO212O, PRO239O, PRO361O, PRO362O, PRO81M, PRO86M, SER116M, SER119M, SER83M, SER95M, THR102M, THR115M, THR187O, THR188O, THR244O, THR249O, THR93M, TRP101M, TRP339O, TRP354O, TRP97M, TYR103M, TYR208O, TYR24O, TYR348O, TYR98M, VAL111M, VAL113M, VAL121M, VAL181O, VAL211O, VAL240O, VAL250O, VAL367O, VAL80M, VAL94M
• N-O: ALA243N, ALA340N, ALA343N, ALA76O, ALA91O, ARG109O, ARG178N, ARG194N, ARG215N, ARG341N, ARG351N, ARG370N, ARG78O, ASN183N, ASN195N, ASP104O, ASP112O, ASP186N, ASP246N, ASP336N, ASP337N, ASP363N, CYS75O, CYS88O, CYS96O, GLN344N, GLN345N, GLN358N, GLU182N, GLU242N, GLU248N, GLU295O, GLU342N, GLU346N, GLU357N, GLU57O, GLU85O, GLY100O, GLY118O, GLY126O, GLY180N, GLY184N, GLY209N, GLY247N, GLY353N, GLY56O, GLY74O, GLY79O, HIS189N, HIS193N, HIS77O, HIS99O, ILE122O, ILE125O, ILE127O, ILE190N, ILE366N, LEU110O, LEU114O, LEU179N, LEU245N, LEU251N, LEU29O, LEU359N, LEU87O, LYS124O, LYS356N, LYS58O, LYS84O, LYS90O, MET192N, MET238N, PHE185N, PHE191N, PHE210N, PHE241N, PHE347N, PHE360N, PHE82O, PHE89O, PRO117O, PRO120O, PRO207N, PRO212N, PRO239N, PRO361N, PRO362N, PRO81O, PRO86O, SER116O, SER119O, SER294O, SER95O, THR102O, THR115O, THR187N, THR188N, THR244N, THR249N, THR53O, THR93O, TRP101O, TRP339N, TRP354N, TRP97O, TYR103O, TYR208N, TYR24N, TYR348N, TYR98O, VAL111O, VAL113O, VAL121O, VAL181N, VAL211N, VAL240N, VAL250N, VAL367N, VAL80O, VAL94O