3G5Y

antibodies specifically targeting a locally misfolded region of tumor associated egfr

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-E
  • Int. Res.: 32
  • Norm. En. per Res.: -6.506
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.7566	-19.6668	-526.358	-589.7814	186	6	12	19731	1	16	11
A-E	-33.7771	-16.6581	-66.556	-116.9912	34	3	1	2669	1	7	3
B-E	-29.1326	-78.699	-100.36	-208.1916	32	1	2	3381	6	10	7

Interface residues

• A-B: ALA128B, ALA130A, ALA171B, ALA34B, ALA97B, ALA99B, ARG101B, ARG211A, ARG216B, ARG39B, ARG59B, ASN137A, ASN138A, ASN157A, ASN161A, ASN210A, ASN32A, ASN36B, ASN44B, ASN53A, ASN61B, ASP165A, ASP167A, ASP170A, ASP1A, ASP56A, ASP85A, CYS134A, CYS143B, CYS88A, CYS96B, GLN108B, GLN124A, GLN174B, GLN37A, GLN38A, GLN40B, GLN6A, GLN90A, GLN93A, GLU123A, GLU213A, GLU214B, GLU47B, GLU55A, GLU6B, GLY100A, GLY100B, GLY101A, GLY102B, GLY107B, GLY109B, GLY129A, GLY142B, GLY147B, GLY158A, GLY165B, GLY34A, GLY41A, GLY43B, GLY46A, GLY50B, GLY51A, GLY99A, HIS167B, HIS50A, ILE117A, ILE213B, ILE33A, ILE38B, ILE48A, LEU125A, LEU127B, LEU136A, LEU141B, LEU144B, LEU160A, LEU173B, LEU177B, LEU179A, LEU180B, LEU181A, LEU36A, LEU3A, LEU46B, LEU47A, LEU64B, LYS146B, LYS169A, LYS207A, LYS211B, LYS212B, LYS42A, LYS45A, LYS45B, LYS65B, MET175A, MET49B, PHE103B, PHE118A, PHE135A, PHE139A, PHE169B, PHE209A, PHE41B, PHE44A, PHE94A, PHE98A, PRO104B, PRO119A, PRO120A, PRO126B, PRO129B, PRO170B, PRO40A, PRO62B, PRO95A, SER103A, SER116A, SER121A, SER123B, SER127A, SER131A, SER138B, SER162A, SER163B, SER164B, SER168A, SER174A, SER175B, SER176A, SER177A, SER181B, SER182B, SER183B, SER208A, SER43A, SER63B, THR114A, THR122A, THR126A, THR140B, THR164A, THR168B, THR172A, THR178A, THR179B, THR180A, THR185B, THR93B, THR97A, THR98B, TRP106B, TRP157B, TRP163A, TRP191B, TRP35A, TRP35B, TRP37B, TRP48B, TRP96A, TYR105B, TYR125B, TYR173A, TYR178B, TYR186A, TYR49A, TYR51B, TYR60B, TYR86A, TYR87A, TYR91A, TYR94B, TYR95B, VAL115A, VAL124B, VAL130B, VAL132A, VAL133A, VAL139B, VAL145B, VAL159A, VAL166B, VAL172B, VAL184B, VAL89A
• A-E: ALA289E, ARG300E, ASN32A, ASN53A, ASP28A, ASP290E, ASP297E, CYS287E, CYS302E, GLN93A, GLU293E, GLU295E, GLU296E, GLY288E, GLY298E, GLY51A, GLY68A, GLY92A, HIS50A, ILE29A, ILE33A, LYS301E, MET294E, PHE94A, SER291E, SER30A, SER31A, SER67A, THR52A, TRP96A, TYR292E, TYR49A, TYR91A, VAL299E
• B-E: ALA34B, ALA56B, ALA99B, ARG101B, ARG300E, ARG59B, ASN36B, ASN57B, ASP297E, ASP32B, GLU293E, GLU295E, GLU296E, GLY100B, GLY102B, GLY298E, ILE52B, LYS301E, MET294E, PHE103B, SER31B, SER53B, SER55B, THR58B, THR98B, TRP35B, TRP48B, TYR27B, TYR33B, TYR51B, TYR54B, VAL299E