3G5X

antibodies specifically targeting a locally misfolded region of tumor associated egfr

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 94
  • Norm. En. per Res.: -1.5275
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-24.9666	-54.9154	10.9578	-68.9242	199	10	10	19662	3	17	15
A-D	-14.1343	8.0853	-137.532	-143.581	94	6	0	5857	0	9	8
C-D	-31.302	-48.673	287.068	207.093	197	14	10	19948	3	17	16

Interface residues

• A-B: ALA126B, ALA130A, ALA169B, ALA34B, ALA97B, ARG39B, ARG59B, ARG99B, ASN137A, ASN138A, ASN161A, ASN210A, ASN32A, ASN36B, ASN44B, ASN53A, ASN61B, ASP131B, ASP165A, ASP167A, ASP170A, ASP1A, ASP1B, ASP55A, ASP56A, ASP85A, CYS129B, CYS134A, CYS141B, CYS214A, CYS88A, CYS94B, GLN106B, GLN124A, GLN166A, GLN172B, GLN37A, GLN38A, GLN3B, GLN40B, GLN6A, GLN90A, GLN93A, GLU123A, GLU212B, GLU213A, GLU47B, GLU57A, GLU6B, GLY100A, GLY100B, GLY101A, GLY105B, GLY107B, GLY128A, GLY128B, GLY129A, GLY130B, GLY134B, GLY140B, GLY158A, GLY34A, GLY41A, GLY43B, GLY46A, GLY50B, GLY51A, GLY98B, GLY99A, HIS165B, HIS50A, ILE117A, ILE33A, ILE38B, ILE48A, LEU125A, LEU125B, LEU136A, LEU139B, LEU142B, LEU160A, LEU170B, LEU171B, LEU179A, LEU181A, LEU211B, LEU36A, LEU3A, LEU46B, LEU47A, LEU54A, LEU64B, LYS103A, LYS144B, LYS169A, LYS207A, LYS209B, LYS39A, LYS42A, LYS45A, LYS45B, LYS65B, MET175A, MET178B, MET49B, PHE101B, PHE118A, PHE135A, PHE139A, PHE167B, PHE209A, PHE33B, PHE44A, PHE94A, PHE98A, PRO102B, PRO119A, PRO120A, PRO124B, PRO127B, PRO168B, PRO40A, PRO62B, PRO95A, SER116A, SER121A, SER121B, SER122A, SER127A, SER131A, SER136B, SER161B, SER162A, SER162B, SER163B, SER168A, SER171A, SER173B, SER174A, SER176A, SER177A, SER179B, SER180B, SER181B, SER208A, SER214B, SER43A, SER53B, SER63B, THR108B, THR114A, THR126A, THR132B, THR133B, THR138B, THR164A, THR166B, THR172A, THR177B, THR178A, THR180A, THR183B, THR91B, THR96B, THR97A, TRP104B, TRP155B, TRP163A, TRP189B, TRP35A, TRP35B, TRP37B, TRP48B, TRP96A, TYR103B, TYR123B, TYR173A, TYR49A, TYR51B, TYR60B, TYR86A, TYR87A, TYR91A, TYR92B, TYR93B, VAL115A, VAL122B, VAL132A, VAL133A, VAL137B, VAL143B, VAL159A, VAL164B, VAL182B, VAL207B, VAL2B, VAL58A, VAL89A, VAL95B
• A-D: ALA114D, ALA202D, ALA69A, ARG61A, ARG67D, ARG72D, ASN30A, ASN53A, ASN57D, ASN583D, ASP143A, ASP17A, ASP70A, ASP73D, CYS23A, GLN16D, GLN6A, GLN78D, GLN82D, GLY101A, GLY16A, GLY51A, GLY56D, GLY64A, GLY66A, GLY68A, GLY8D, HIS24A, HIS50A, ILE21A, ILE48A, ILE75A, LEU11D, LEU18D, LEU20D, LEU54A, LEU73A, LEU81D, LEU83D, LYS107A, LYS116D, LYS13D, LYS199A, LYS76D, MET11A, PHE147D, PHE62A, PHE80D, PRO148D, PRO14D, PRO8A, PRO9D, SER10A, SER10D, SER113D, SER12A, SER15D, SER17D, SER19D, SER204D, SER20A, SER31A, SER55D, SER584D, SER60A, SER63A, SER65A, SER67A, SER69D, SER72A, SER75D, SER76A, SER77A, SER7A, SER7D, SER9A, THR102A, THR111D, THR117D, THR18A, THR21D, THR22A, THR52A, THR5A, THR71D, THR74A, THR74D, TRP35A, TYR71A, VAL112D, VAL12D, VAL13A, VAL19A, VAL84D
• C-D: ALA126D, ALA130C, ALA169D, ALA34D, ALA97D, ARG211C, ARG39D, ARG59D, ARG99D, ASN137C, ASN138C, ASN161C, ASN210C, ASN32C, ASN36D, ASN44D, ASN53C, ASN61D, ASP131D, ASP165C, ASP167C, ASP170C, ASP1C, ASP1D, ASP55C, ASP56C, ASP85C, CYS129D, CYS134C, CYS141D, CYS214C, CYS88C, CYS94D, GLN106D, GLN124C, GLN172D, GLN37C, GLN38C, GLN3D, GLN40D, GLN6C, GLN90C, GLN93C, GLU123C, GLU213C, GLU47D, GLU57C, GLU6D, GLY100C, GLY100D, GLY101C, GLY105D, GLY107D, GLY128C, GLY128D, GLY129C, GLY130D, GLY134D, GLY140D, GLY158C, GLY34C, GLY41C, GLY43D, GLY46C, GLY50D, GLY51C, GLY98D, GLY99C, HIS165D, HIS50C, ILE117C, ILE33C, ILE38D, ILE48C, LEU125C, LEU125D, LEU136C, LEU139D, LEU142D, LEU160C, LEU160D, LEU170D, LEU171D, LEU179C, LEU181C, LEU211D, LEU36C, LEU3C, LEU46D, LEU47C, LEU54C, LEU64D, LYS103C, LYS144D, LYS169C, LYS207C, LYS209D, LYS39C, LYS42C, LYS45C, LYS45D, LYS65D, MET175C, MET178D, MET49D, PHE101D, PHE118C, PHE135C, PHE139C, PHE167D, PHE209C, PHE44C, PHE94C, PHE98C, PRO102D, PRO119C, PRO120C, PRO124D, PRO127D, PRO168D, PRO40C, PRO62D, PRO95C, SER116C, SER121C, SER121D, SER122C, SER127C, SER131C, SER135D, SER136D, SER162C, SER162D, SER163D, SER173D, SER174C, SER176C, SER177C, SER179D, SER180D, SER181D, SER208C, SER214D, SER43C, SER63D, SER9C, THR108D, THR114C, THR126C, THR132D, THR133D, THR138D, THR164C, THR166D, THR172C, THR177D, THR178C, THR180C, THR183D, THR91D, THR96D, THR97C, TRP104D, TRP155D, TRP163C, TRP189D, TRP35C, TRP35D, TRP37D, TRP48D, TRP96C, TYR103D, TYR123D, TYR173C, TYR186C, TYR49C, TYR51D, TYR60D, TYR86C, TYR87C, TYR91C, TYR92D, TYR93D, VAL115C, VAL122D, VAL132C, VAL133C, VAL137D, VAL143D, VAL159C, VAL164D, VAL182D, VAL207D, VAL2D, VAL58C, VAL89C, VAL95D