3G5V

antibodies specifically targeting a locally misfolded region of tumor associated egfr

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 34
  • Norm. En. per Res.: -4.8673
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-46.8133	-16.3932	-523.573	-586.7796	177	10	10	19441	1	16	15
A-C	-38.8421	-14.1404	-84.7354	-137.7179	35	4	1	3061	1	7	3
B-C	-24.5622	-45.9697	-94.9553	-165.4872	34	3	2	3414	4	10	7

Interface residues

• A-B: ALA128B, ALA130A, ALA171B, ALA213B, ALA34B, ALA92B, ALA99B, ARG101B, ARG39B, ARG59B, ASN137A, ASN138A, ASN161A, ASN32A, ASN36B, ASN44B, ASN53A, ASN61B, ASP165A, ASP167A, ASP170A, ASP1A, ASP1B, ASP55A, ASP56A, ASP85A, CYS134A, CYS143B, CYS88A, CYS96B, GLN108B, GLN124A, GLN174B, GLN37A, GLN38A, GLN40B, GLN6A, GLN90A, GLN93A, GLU123A, GLU47B, GLU57A, GLY100A, GLY100B, GLY101A, GLY102B, GLY107B, GLY109B, GLY128A, GLY129A, GLY142B, GLY158A, GLY34A, GLY41A, GLY43B, GLY46A, GLY50B, GLY51A, GLY99A, HIS167B, HIS50A, ILE117A, ILE33A, ILE38B, ILE48A, LEU111B, LEU125A, LEU127B, LEU136A, LEU141B, LEU144B, LEU160A, LEU162B, LEU172B, LEU173B, LEU177B, LEU179A, LEU181A, LEU36A, LEU46B, LEU47A, LEU54A, LEU64B, LYS103A, LYS142A, LYS146B, LYS169A, LYS211B, LYS212B, LYS42A, LYS45A, LYS45B, LYS65B, MET175A, MET180B, MET49B, PHE103B, PHE118A, PHE135A, PHE139A, PHE169B, PHE209A, PHE41B, PHE44A, PHE94A, PHE98A, PRO104B, PRO119A, PRO120A, PRO126B, PRO129B, PRO170B, PRO42B, PRO62B, PRO95A, SER116A, SER121A, SER122A, SER123B, SER127A, SER131A, SER162A, SER163B, SER168A, SER174A, SER175B, SER176A, SER177A, SER181B, SER182B, SER183B, SER43A, SER63B, THR110B, THR114A, THR126A, THR140B, THR164A, THR168B, THR172A, THR178A, THR179B, THR180A, THR185B, THR93B, THR97A, THR98B, TRP106B, TRP163A, TRP35A, TRP35B, TRP37B, TRP48B, TRP96A, TYR105B, TYR125B, TYR173A, TYR178B, TYR49A, TYR51B, TYR60B, TYR86A, TYR87A, TYR91A, TYR94B, TYR95B, VAL115A, VAL124B, VAL132A, VAL133A, VAL145B, VAL159A, VAL166B, VAL184B, VAL58A, VAL89A, VAL97B
• A-C: ALA289C, ALA92A, ARG300C, ASN30A, ASN32A, ASN53A, ASP28A, ASP290C, ASP297C, CYS287C, CYS302C, GLN93A, GLU293C, GLU295C, GLU296C, GLY288C, GLY298C, GLY51A, GLY66A, GLY68A, HIS50A, ILE29A, ILE33A, LYS301C, MET294C, PHE94A, SER31A, SER67A, THR52A, TRP96A, TYR292C, TYR49A, TYR71A, TYR91A, VAL299C
• B-C: ALA34B, ALA99B, ARG101B, ARG300C, ARG59B, ASN36B, ASN57B, ASP297C, ASP32B, CYS287C, GLU293C, GLU295C, GLU296C, GLY100B, GLY102B, GLY298C, GLY56B, ILE52B, LYS301C, MET294C, PHE103B, PHE33B, PRO104B, SER31B, SER53B, SER55B, THR58B, THR98B, TRP35B, TRP48B, TYR27B, TYR51B, TYR54B, VAL299C