3G5K

structure and activity of human mitochondrial peptide deformylase, a novel cancer target

• Total interactions analyzed: 6
• Total true interactions: 2
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 84
  • Norm. En. per Res.: -3.4326
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-46.5557	22.2941	-259.589	-283.8506	84	16	4	9015	0	14	11
C-D	-51.8686	24.3424	-260.815	-288.3412	84	20	4	9035	0	14	11

Interface residues

• A-B: ALA118A, ALA118B, ALA122A, ALA122B, ARG173A, ARG173B, ARG18A, ARG18B, ASN177A, ASN177B, ASP14A, ASP14B, ASP159A, ASP159B, ASP168A, ASP168B, ASP171A, ASP171B, CYS10A, CYS10B, CYS164A, CYS164B, GLN11A, GLN11B, GLN162A, GLN162B, GLY119A, GLY119B, GLY13A, GLY13B, GLY163A, GLY163B, GLY19A, GLY19B, HIS8A, HIS8B, ILE167A, ILE167B, LEU121A, LEU121B, LEU165A, LEU165B, LEU17A, LEU17B, LYS169A, LYS169B, LYS182A, LYS182B, MET170A, MET170B, MET181A, MET181B, PHE120A, PHE120B, PHE166A, PHE166B, PHE175A, PHE175B, PRO15A, PRO15B, SER116A, SER116B, SER172A, SER172B, THR174A, THR174B, THR176A, THR176B, TRP180A, TRP180B, TYR179A, TYR179B, VAL117A, VAL117B, VAL12A, VAL12B, VAL16A, VAL16B, VAL178A, VAL178B, VAL20A, VAL20B, VAL9A, VAL9B
• C-D: ALA118C, ALA118D, ALA122C, ALA122D, ARG173C, ARG173D, ARG18C, ARG18D, ASN177C, ASN177D, ASP14C, ASP14D, ASP159C, ASP159D, ASP168C, ASP168D, ASP171C, ASP171D, CYS10C, CYS10D, CYS164C, CYS164D, GLN11C, GLN11D, GLN162C, GLN162D, GLY119C, GLY119D, GLY13C, GLY13D, GLY163C, GLY163D, GLY19C, GLY19D, HIS8C, HIS8D, ILE167C, ILE167D, LEU121C, LEU121D, LEU165C, LEU165D, LEU17C, LEU17D, LYS169C, LYS169D, LYS182C, LYS182D, MET170C, MET170D, MET181C, MET181D, PHE120C, PHE120D, PHE166C, PHE166D, PHE175C, PHE175D, PRO15C, PRO15D, SER116C, SER116D, SER172C, SER172D, THR174C, THR174D, THR176C, THR176D, TRP180C, TRP180D, TYR179C, TYR179D, VAL117C, VAL117D, VAL12C, VAL12D, VAL16C, VAL16D, VAL178C, VAL178D, VAL20C, VAL20D, VAL9C, VAL9D