3G4G

crystal structure of human phosphodiesterase 4d with regulatory domain and d155871

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 88
  • Norm. En. per Res.: -3.0874
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-31.6469	-61.8115	-178.235	-271.6935	88	10	4	7141	4	21	8
B-C	-2.3559	-50.0678	-66.873	-119.2966	60	1	1	2980	2	29	33
C-D	-30.0664	-59.318	-175.648	-265.0324	87	9	4	7059	4	20	8

Interface residues

• A-B: ALA386A, ALA386B, ALA401A, ALA401B, ARG423A, ARG423B, ARG427A, ARG427B, ASN380A, ASN380B, ASN382A, ASN382B, ASN390A, ASN390B, ASN397A, ASN397B, ASP203A, ASP203B, ASP391A, ASP391B, ASP432A, ASP432B, GLN376A, GLN376B, GLN408A, GLN408B, GLN424A, GLN424B, GLU384A, GLU384B, GLU396A, GLU396B, GLY403A, GLY403B, HIS398A, HIS398B, HIS399A, HIS399B, ILE365A, ILE365B, ILE379A, ILE379B, ILE431A, ILE431B, LEU385A, LEU385B, LEU387A, LEU387B, LEU395A, LEU395B, LEU400A, LEU400B, LEU406A, LEU406B, LEU407A, LEU407B, LEU435A, LEU435B, LYS405A, LYS405B, LYS420A, LYS420B, LYS428A, LYS428B, MET388A, MET388B, MET518A, MET518B, PHE404A, PHE404B, SER383A, SER383B, SER392A, SER392B, SER393A, SER393B, THR381A, THR381B, TYR389A, TYR389B, VAL394A, VAL394B, VAL402A, VAL402B, VAL430A, VAL430B, VAL434A, VAL434B
• B-C: ARG274B, ARG274C, ARG496B, ARG496C, ASN568B, ASN568C, ASP500C, ASP560B, ASP560C, ASP563B, ASP563C, ASP567B, ASP567C, GLN493B, GLN493C, GLN497C, GLN559B, GLN573B, GLN578B, GLN578C, GLU261C, GLU263C, GLU277C, GLU532B, GLU532C, GLU566B, GLU570B, GLU570C, HIS271B, HIS271C, ILE561B, ILE576B, ILE576C, LEU278C, LEU492B, LEU492C, LEU494C, LEU562B, LEU565B, LYS260C, LYS267B, LYS267C, LYS490B, PRO491B, PRO491C, PRO577B, PRO577C, SER574B, SER574C, THR489B, THR564B, THR564C, THR575B, THR575C, TRP571B, TRP571C, TYR495C, TYR572B, TYR572C, VAL257C
• C-D: ALA386C, ALA386D, ALA401C, ALA401D, ARG423C, ARG423D, ARG427C, ARG427D, ARG516D, ASN380C, ASN380D, ASN382C, ASN382D, ASN390C, ASN390D, ASN397C, ASN397D, ASP203C, ASP203D, ASP391C, ASP391D, ASP432C, ASP432D, GLN376C, GLN376D, GLN408C, GLN408D, GLN424C, GLN424D, GLU384C, GLU384D, GLU396C, GLU396D, GLY403C, GLY403D, HIS398C, HIS398D, HIS399C, HIS399D, ILE365D, ILE379C, ILE379D, ILE431C, ILE431D, LEU385C, LEU385D, LEU387C, LEU387D, LEU395C, LEU395D, LEU400C, LEU400D, LEU406C, LEU406D, LEU407C, LEU407D, LEU435C, LEU435D, LYS405C, LYS405D, LYS420C, LYS420D, LYS428C, LYS428D, MET388C, MET388D, MET518C, MET518D, PHE404C, PHE404D, SER383C, SER383D, SER392C, SER392D, SER393C, SER393D, THR381D, TYR389C, TYR389D, VAL394C, VAL394D, VAL402C, VAL402D, VAL430C, VAL430D, VAL434C, VAL434D