3G37

cryo-em structure of actin filament in the presence of phosphate

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: Q-S
  • Int. Res.: 95
  • Norm. En. per Res.: -3.9801
• Hub Node: O(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
O-P	-16.9366	-43.828	-195.298	-256.0626	124	14	0	8937	2	49	38
O-Q	-68.0354	-31.1171	-286.858	-386.0105	99	25	3	10889	5	27	35
P-Q	-35.0953	-40.5067	-210.762	-286.3639	127	14	0	9269	2	46	38
P-R	-39.5415	-10.7772	-251.735	-302.0537	95	16	3	10228	2	28	28
Q-R	-33.0616	-43.3356	-187.772	-264.1691	123	16	0	8827	2	45	36
Q-S	-64.4594	-38.9195	-274.735	-378.1139	95	27	3	10600	2	29	31
R-S	-27.6648	-36.1857	-184.34	-248.1904	126	15	0	8880	2	46	37
R-T	-55.5011	-44.9292	-259.172	-359.6024	99	19	3	10804	4	29	33
S-T	-5.7555	-36.3318	-183.717	-225.8044	126	14	0	8707	2	46	40
S-U	-36.4935	-3.0333	-267.188	-306.7148	99	20	4	10912	1	28	34
T-U	-19.4284	-44.0694	-178.206	-241.7038	119	15	0	8207	1	46	38
T-V	-56.5621	-24.3315	-268.848	-349.7415	96	21	3	10798	3	27	34
U-V	-13.4301	-40.9798	-207.767	-262.1769	125	9	0	9230	3	47	39
U-W	-26.2778	-3.3876	-272.225	-301.8904	97	13	3	10542	2	27	33
V-W	-21.2727	-38.4104	-202.737	-262.4201	138	17	0	9354	2	48	40
V-X	-34.2955	-10.1242	-276.042	-320.4616	98	20	3	10818	2	28	34
W-X	-13.7794	-34.8907	-185.284	-233.9541	130	11	0	8773	2	46	38
W-Y	-39.1938	-20.1631	-277.074	-336.431	101	12	3	10695	2	27	33
X-Y	-12.3821	-36.2282	-195.007	-243.6173	134	15	0	9087	1	46	40
X-Z	-36.7829	-14.4202	-264.417	-315.6201	97	20	3	10712	3	29	35
Y-Z	-9.1312	-46.105	-212.457	-267.6932	130	16	0	9205	2	48	41

Interface residues

• O-P: ALA108P, ALA114P, ALA174P, ALA204O, ALA228O, ALA230O, ALA231O, ALA272P, ALA365P, ALA58O, ARG116P, ARG177P, ARG183O, ARG183P, ARG196O, ARG206O, ARG256O, ARG256P, ARG37O, ARG39O, ARG62O, ASN111P, ASN115P, ASN252O, ASN280P, ASN78P, ASP179P, ASP184O, ASP184P, ASP187O, ASP286P, CYS285P, GLN246O, GLN263P, GLN41O, GLU107P, GLU117P, GLU195O, GLU195P, GLU207O, GLU224O, GLU224P, GLU237O, GLU253O, GLU259P, GLU270O, GLU270P, GLU276P, GLU72P, GLY158P, GLY197O, GLY251O, GLY268O, GLY268P, GLY273P, GLY366P, GLY36O, GLY42O, GLY63O, GLY74P, HIS173P, HIS371P, HIS40O, ILE175P, ILE192O, ILE192P, ILE248O, ILE267O, ILE267P, ILE64O, ILE75P, ILE76P, LEU110P, LEU178P, LEU180O, LEU180P, LEU193O, LEU65O, LEU67O, LYS113P, LYS118P, LYS191O, LYS191P, LYS284P, LYS61O, LYS68O, MET176P, MET190O, MET227O, MET269O, MET269P, PHE200O, PHE223O, PHE223P, PHE255O, PHE266P, PRO109P, PRO112P, PRO172P, PRO264O, PRO264P, PRO367P, PRO38O, SER199O, SER232O, SER265O, SER265P, SER271O, SER271P, SER368P, THR194O, THR202O, THR203O, THR249O, THR260P, THR66O, THR77P, TRP79P, TYR188O, TYR198O, VAL159P, VAL201O, VAL247O, VAL43O
• O-Q: ALA108Q, ALA135Q, ALA138Q, ALA170Q, ALA174Q, ALA204O, ALA321Q, ALA58O, ARG116Q, ARG206O, ARG290Q, ARG372Q, ARG62O, ASN111Q, ASN280Q, ASP211O, ASP244O, ASP286Q, ASP288Q, ASP51O, CYS285Q, CYS374Q, GLN137Q, GLN246O, GLN41O, GLN49O, GLN59O, GLU107Q, GLU167Q, GLU205O, GLU207O, GLU241O, GLU57O, GLY168Q, GLY245O, GLY42O, GLY46O, GLY48O, GLY63O, HIS173Q, HIS371Q, HIS40O, ILE136Q, ILE165Q, ILE175Q, ILE208O, ILE282Q, ILE287Q, ILE289Q, ILE64O, LEU110Q, LEU171Q, LEU242O, LEU320Q, LEU65O, LYS113Q, LYS284Q, LYS291Q, LYS373Q, LYS50O, LYS61O, MET283Q, MET325Q, MET355Q, MET44O, MET47O, PHE200O, PHE375Q, PRO109Q, PRO112Q, PRO164Q, PRO172Q, PRO243O, PRO322Q, SER281Q, SER323Q, SER60O, THR149Q, THR202O, THR203O, THR324Q, THR351Q, TYR133Q, TYR143Q, TYR166Q, TYR169Q, TYR198O, TYR240O, TYR279Q, TYR294Q, TYR53O, VAL134Q, VAL139Q, VAL163Q, VAL201O, VAL209O, VAL370Q, VAL43O, VAL45O
• P-Q: ALA108Q, ALA114Q, ALA174Q, ALA204P, ALA228P, ALA230P, ALA231P, ALA272Q, ALA365Q, ARG116Q, ARG177Q, ARG183P, ARG183Q, ARG196P, ARG206P, ARG256P, ARG256Q, ARG312Q, ARG37P, ARG39P, ARG62P, ASN111Q, ASN115Q, ASN252P, ASN280Q, ASN78Q, ASP179Q, ASP184P, ASP184Q, ASP187P, ASP286Q, CYS285Q, GLN246P, GLN263Q, GLN41P, GLU117Q, GLU195P, GLU195Q, GLU205P, GLU207P, GLU224Q, GLU237P, GLU253P, GLU259Q, GLU270P, GLU270Q, GLU276Q, GLU72Q, GLY158Q, GLY197P, GLY251P, GLY268P, GLY268Q, GLY273Q, GLY366Q, GLY36P, GLY42P, GLY63P, GLY74Q, HIS173Q, HIS275Q, HIS371Q, HIS40P, ILE175Q, ILE192P, ILE192Q, ILE248P, ILE250P, ILE267P, ILE267Q, ILE64P, ILE75Q, ILE76Q, LEU110Q, LEU171Q, LEU178Q, LEU180Q, LEU193P, LEU65P, LEU67P, LYS113Q, LYS118Q, LYS191P, LYS191Q, LYS284Q, LYS68P, MET176Q, MET190P, MET227P, MET227Q, MET269P, MET269Q, MET44P, MET47P, PHE200P, PHE223P, PHE223Q, PHE255P, PHE266P, PHE266Q, PRO109Q, PRO112Q, PRO172Q, PRO264Q, PRO367Q, PRO38P, SER199P, SER232P, SER234P, SER265P, SER265Q, SER271Q, SER368Q, THR194P, THR202P, THR203P, THR249P, THR260Q, THR66P, THR77Q, TRP79Q, TYR188P, TYR198P, VAL159Q, VAL201P, VAL247P, VAL43P
• P-R: ALA108R, ALA135R, ALA138R, ALA170R, ALA174R, ALA204P, ALA321R, ARG116R, ARG206P, ARG290R, ARG372R, ARG62P, ASN111R, ASN280R, ASP211P, ASP244P, ASP286R, ASP288R, ASP51P, CYS285R, CYS374R, GLN246P, GLN41P, GLN49P, GLN59P, GLU107R, GLU167R, GLU205P, GLU207P, GLU241P, GLU57P, GLY168R, GLY245P, GLY42P, GLY46P, GLY48P, GLY63P, HIS173R, HIS371R, HIS40P, ILE136R, ILE165R, ILE175R, ILE208P, ILE282R, ILE287R, ILE289R, ILE64P, LEU110R, LEU171R, LEU242P, LEU320R, LEU65P, LYS113R, LYS284R, LYS291R, LYS373R, LYS50P, LYS61P, MET283R, MET325R, MET355R, MET44P, MET47P, PHE375R, PRO109R, PRO164R, PRO172R, PRO243P, PRO322R, SER281R, SER323R, SER52P, SER60P, THR149R, THR202P, THR203P, THR324R, TYR133R, TYR143R, TYR166R, TYR169R, TYR198P, TYR240P, TYR279R, TYR294R, TYR53P, VAL134R, VAL139R, VAL163R, VAL201P, VAL209P, VAL370R, VAL43P, VAL45P
• Q-R: ALA108R, ALA114R, ALA174R, ALA204Q, ALA228Q, ALA230Q, ALA231Q, ALA272R, ALA365R, ALA58Q, ARG116R, ARG177R, ARG183Q, ARG183R, ARG196Q, ARG206Q, ARG256Q, ARG256R, ARG312R, ARG37Q, ARG39Q, ARG62Q, ASN111R, ASN115R, ASN252Q, ASN280R, ASN78R, ASP179R, ASP184Q, ASP184R, ASP187Q, ASP286R, GLN246Q, GLN263R, GLN41Q, GLU117R, GLU195Q, GLU205Q, GLU207Q, GLU224Q, GLU224R, GLU237Q, GLU253Q, GLU259R, GLU270Q, GLU270R, GLU276R, GLU72R, GLY158R, GLY197Q, GLY251Q, GLY268Q, GLY268R, GLY273R, GLY366R, GLY36Q, GLY42Q, GLY63Q, GLY74R, HIS161R, HIS173R, HIS275R, HIS371R, HIS40Q, ILE175R, ILE192Q, ILE267Q, ILE267R, ILE287R, ILE34Q, ILE64Q, ILE75R, ILE76R, LEU110R, LEU178R, LEU180R, LEU193Q, LEU65Q, LEU67Q, LYS113R, LYS118R, LYS191Q, LYS191R, LYS284R, LYS68Q, MET176R, MET190Q, MET227Q, MET227R, MET269Q, MET269R, MET47Q, PHE200Q, PHE223Q, PHE223R, PHE255Q, PHE262R, PHE266R, PRO109R, PRO112R, PRO172R, PRO264R, PRO367R, PRO38Q, SER199Q, SER232Q, SER265R, SER271R, SER368R, THR194Q, THR202Q, THR203Q, THR249Q, THR260R, THR66Q, THR77R, TRP79R, TYR188Q, TYR198Q, VAL159R, VAL201Q, VAL247Q, VAL43Q
• Q-S: ALA108S, ALA135S, ALA138S, ALA170S, ALA174S, ALA204Q, ALA321S, ALA58Q, ARG116S, ARG206Q, ARG290S, ARG372S, ARG62Q, ASN111S, ASN280S, ASP211Q, ASP244Q, ASP286S, ASP288S, ASP51Q, CYS285S, CYS374S, GLN246Q, GLN41Q, GLN49Q, GLN59Q, GLU107S, GLU167S, GLU205Q, GLU207Q, GLU241Q, GLU57Q, GLY168S, GLY245Q, GLY42Q, GLY46Q, GLY48Q, GLY63Q, HIS173S, HIS371S, HIS40Q, ILE136S, ILE165S, ILE175S, ILE208Q, ILE282S, ILE287S, ILE289S, ILE64Q, LEU110S, LEU140S, LEU171S, LEU242Q, LEU320S, LEU65Q, LYS284S, LYS291S, LYS373S, LYS50Q, LYS61Q, MET283S, MET325S, MET355S, MET44Q, MET47Q, PHE375S, PRO109S, PRO164S, PRO172S, PRO243Q, PRO322S, SER281S, SER323S, SER52Q, SER60Q, THR202Q, THR203Q, THR324S, TYR133S, TYR143S, TYR166S, TYR169S, TYR198Q, TYR240Q, TYR279S, TYR294S, TYR53Q, VAL134S, VAL139S, VAL163S, VAL201Q, VAL209Q, VAL370S, VAL43Q, VAL45Q
• R-S: ALA108S, ALA114S, ALA174S, ALA204R, ALA228R, ALA230R, ALA231R, ALA272S, ALA365S, ALA58R, ARG116S, ARG177S, ARG183R, ARG183S, ARG196R, ARG206R, ARG256R, ARG256S, ARG312S, ARG37R, ARG39R, ARG62R, ASN111S, ASN115S, ASN252R, ASN280S, ASN78S, ASP179S, ASP184R, ASP184S, ASP187R, ASP286S, CYS285S, GLN246R, GLN263S, GLN41R, GLU117S, GLU195R, GLU195S, GLU207R, GLU224R, GLU224S, GLU237R, GLU253R, GLU259S, GLU270R, GLU270S, GLU276S, GLU72S, GLY158S, GLY197R, GLY251R, GLY268R, GLY268S, GLY273S, GLY366S, GLY36R, GLY42R, GLY63R, GLY74S, HIS161S, HIS173S, HIS371S, HIS40R, ILE175S, ILE192R, ILE248R, ILE267R, ILE267S, ILE287S, ILE34R, ILE64R, ILE75S, ILE76S, LEU110S, LEU178S, LEU180S, LEU193R, LEU65R, LEU67R, LYS113S, LYS118S, LYS191R, LYS191S, LYS284S, LYS61R, LYS68R, MET176S, MET190R, MET227R, MET269R, MET269S, PHE200R, PHE223R, PHE223S, PHE255R, PHE266R, PHE266S, PRO109S, PRO112S, PRO172S, PRO264R, PRO264S, PRO367S, PRO38R, SER199R, SER232R, SER234R, SER265R, SER265S, SER271S, SER368S, THR194R, THR202R, THR203R, THR249R, THR260S, THR66R, THR77S, TRP79S, TYR188R, TYR198R, VAL159S, VAL201R, VAL247R, VAL43R
• R-T: ALA108T, ALA135T, ALA138T, ALA170T, ALA174T, ALA204R, ALA321T, ALA58R, ARG116T, ARG206R, ARG210R, ARG290T, ARG372T, ARG62R, ASN111T, ASN280T, ASP211R, ASP244R, ASP286T, ASP288T, ASP51R, CYS285T, CYS374T, GLN137T, GLN246R, GLN41R, GLN49R, GLN59R, GLU107T, GLU167T, GLU205R, GLU207R, GLU241R, GLU57R, GLY168T, GLY245R, GLY42R, GLY46R, GLY48R, GLY63R, HIS173T, HIS371T, HIS40R, ILE136T, ILE165T, ILE175T, ILE208R, ILE282T, ILE287T, ILE289T, ILE64R, LEU110T, LEU171T, LEU242R, LEU320T, LEU65R, LEU67R, LYS284T, LYS291T, LYS373T, LYS50R, LYS61R, MET283T, MET325T, MET355T, MET44R, MET47R, PHE200R, PHE375T, PRO109T, PRO164T, PRO172T, PRO243R, PRO322T, SER323T, SER60R, THR148T, THR149T, THR202R, THR203R, THR324T, THR351T, TYR133T, TYR143T, TYR166T, TYR169T, TYR198R, TYR240R, TYR279T, TYR294T, TYR53R, VAL134T, VAL139T, VAL163T, VAL201R, VAL209R, VAL370T, VAL43R, VAL45R
• S-T: ALA108T, ALA114T, ALA174T, ALA204S, ALA228S, ALA230S, ALA231S, ALA272T, ALA365T, ARG116T, ARG177T, ARG183S, ARG183T, ARG196S, ARG206S, ARG256S, ARG256T, ARG312T, ARG37S, ARG39S, ARG62S, ASN111T, ASN115T, ASN252S, ASN280T, ASN78T, ASP179T, ASP184S, ASP184T, ASP187S, ASP286T, CYS285T, GLN246S, GLN263T, GLN41S, GLU117T, GLU195S, GLU207S, GLU224S, GLU224T, GLU237S, GLU253S, GLU259T, GLU270S, GLU270T, GLU276T, GLU72T, GLY158T, GLY197S, GLY251S, GLY268S, GLY268T, GLY273T, GLY366T, GLY42S, GLY63S, GLY74T, HIS161T, HIS173T, HIS275T, HIS371T, HIS40S, ILE175T, ILE192S, ILE192T, ILE248S, ILE267S, ILE267T, ILE287T, ILE64S, ILE75T, ILE76T, LEU110T, LEU178T, LEU180T, LEU193S, LEU65S, LEU67S, LYS113T, LYS118T, LYS191S, LYS191T, LYS284T, LYS61S, LYS68S, MET176T, MET190S, MET227S, MET227T, MET269S, MET269T, PHE200S, PHE223S, PHE223T, PHE255S, PHE262T, PHE266T, PRO109T, PRO112T, PRO172T, PRO264S, PRO264T, PRO367T, PRO38S, SER199S, SER232S, SER233S, SER265S, SER265T, SER271S, SER271T, SER368T, THR194S, THR202S, THR203S, THR249S, THR260T, THR66S, THR77T, TRP79T, TYR188S, TYR198S, VAL159T, VAL201S, VAL247S, VAL43S
• S-U: ALA108U, ALA135U, ALA138U, ALA170U, ALA174U, ALA204S, ALA321U, ALA58S, ARG116U, ARG206S, ARG290U, ARG372U, ARG39S, ARG62S, ASN111U, ASP211S, ASP244S, ASP286U, ASP288U, ASP51S, CYS285U, CYS374U, GLN137U, GLN246S, GLN41S, GLN49S, GLN59S, GLU107U, GLU167U, GLU205S, GLU207S, GLU241S, GLU57S, GLY168U, GLY245S, GLY42S, GLY46S, GLY48S, GLY63S, HIS173U, HIS371U, HIS40S, ILE136U, ILE165U, ILE175U, ILE208S, ILE282U, ILE287U, ILE289U, ILE64S, LEU110U, LEU140U, LEU171U, LEU242S, LEU320U, LEU65S, LEU67S, LYS113U, LYS284U, LYS291U, LYS373U, LYS50S, LYS61S, MET283U, MET325U, MET355U, MET44S, MET47S, PHE200S, PHE375U, PRO109U, PRO164U, PRO172U, PRO243S, PRO322U, SER281U, SER323U, SER60S, THR149U, THR202S, THR203S, THR324U, TYR133U, TYR143U, TYR166U, TYR169U, TYR198S, TYR240S, TYR279U, TYR294U, TYR53S, VAL134U, VAL139U, VAL163U, VAL201S, VAL209S, VAL370U, VAL43S, VAL45S
• T-U: ALA108U, ALA114U, ALA174U, ALA204T, ALA228T, ALA230T, ALA231T, ALA272U, ALA365U, ARG116U, ARG177U, ARG183T, ARG183U, ARG196T, ARG206T, ARG256T, ARG256U, ARG37T, ARG39T, ARG62T, ASN111U, ASN115U, ASN252T, ASN280U, ASN78U, ASP179U, ASP184T, ASP184U, ASP187T, ASP286U, CYS285U, GLN246T, GLN263U, GLN41T, GLU107U, GLU117U, GLU195T, GLU207T, GLU224T, GLU224U, GLU237T, GLU253T, GLU259U, GLU270T, GLU270U, GLU276U, GLU72U, GLY158U, GLY197T, GLY251T, GLY268T, GLY268U, GLY273U, GLY366U, GLY36T, GLY63T, GLY74U, HIS161U, HIS173U, HIS371U, HIS40T, ILE175U, ILE192T, ILE267T, ILE267U, ILE287U, ILE64T, ILE75U, ILE76U, LEU110U, LEU171U, LEU178U, LEU180U, LEU193T, LEU65T, LEU67T, LYS113U, LYS118U, LYS191T, LYS191U, LYS284U, LYS68T, MET176U, MET190T, MET227T, MET227U, MET269T, MET269U, PHE200T, PHE223T, PHE223U, PHE255T, PHE266U, PRO109U, PRO112U, PRO172U, PRO264T, PRO264U, PRO367U, PRO38T, SER199T, SER232T, SER265T, SER265U, SER271U, SER368U, THR194T, THR202T, THR203T, THR249T, THR66T, THR77U, TRP79U, TYR188T, TYR198T, VAL159U, VAL201T, VAL247T, VAL43T
• T-V: ALA108V, ALA135V, ALA138V, ALA170V, ALA174V, ALA204T, ALA321V, ARG116V, ARG206T, ARG290V, ARG372V, ARG39T, ARG62T, ASN111V, ASP211T, ASP244T, ASP286V, ASP288V, ASP51T, CYS285V, CYS374V, GLN137V, GLN246T, GLN41T, GLN49T, GLN59T, GLU107V, GLU167V, GLU205T, GLU207T, GLU241T, GLU57T, GLY168V, GLY245T, GLY42T, GLY46T, GLY48T, GLY63T, HIS173V, HIS371V, HIS40T, ILE136V, ILE165V, ILE175V, ILE208T, ILE282V, ILE287V, ILE289V, ILE64T, LEU110V, LEU140V, LEU171V, LEU242T, LEU320V, LEU65T, LYS284V, LYS291V, LYS373V, LYS50T, LYS61T, MET283V, MET325V, MET355V, MET44T, MET47T, PHE200T, PHE375V, PRO109V, PRO164V, PRO172V, PRO243T, PRO322V, SER323V, SER60T, THR149V, THR202T, THR203T, THR324V, THR351V, TYR133V, TYR143V, TYR166V, TYR169V, TYR198T, TYR240T, TYR279V, TYR294V, TYR53T, VAL134V, VAL139V, VAL163V, VAL201T, VAL209T, VAL370V, VAL43T, VAL45T
• U-V: ALA108V, ALA114V, ALA174V, ALA204U, ALA228U, ALA230U, ALA231U, ALA272V, ALA365V, ARG116V, ARG177V, ARG183U, ARG183V, ARG196U, ARG206U, ARG256U, ARG256V, ARG312V, ARG37U, ARG39U, ARG62U, ASN111V, ASN115V, ASN252U, ASN280V, ASN78V, ASP179V, ASP184U, ASP184V, ASP187U, ASP286V, GLN246U, GLN263V, GLN41U, GLU107V, GLU117V, GLU195U, GLU195V, GLU207U, GLU224U, GLU224V, GLU237U, GLU253U, GLU259V, GLU270U, GLU270V, GLU276V, GLU72V, GLY158V, GLY197U, GLY251U, GLY268U, GLY268V, GLY273V, GLY366V, GLY36U, GLY42U, GLY63U, GLY74V, HIS161V, HIS173V, HIS275V, HIS371V, HIS40U, ILE175V, ILE192U, ILE192V, ILE267U, ILE267V, ILE64U, ILE75V, ILE76V, LEU110V, LEU178V, LEU180V, LEU193U, LEU65U, LEU67U, LYS113V, LYS118V, LYS191U, LYS191V, LYS284V, LYS61U, LYS68U, MET176V, MET190U, MET227U, MET227V, MET269U, MET269V, PHE200U, PHE223U, PHE223V, PHE255U, PHE266V, PRO109V, PRO112V, PRO172V, PRO264U, PRO264V, PRO367V, PRO38U, SER199U, SER232U, SER233U, SER234U, SER265U, SER265V, SER271V, SER368V, THR194U, THR202U, THR203U, THR249U, THR260V, THR66U, THR77V, TRP79V, TYR188U, TYR198U, VAL159V, VAL201U, VAL247U, VAL43U
• U-W: ALA108W, ALA135W, ALA138W, ALA170W, ALA174W, ALA204U, ALA321W, ALA58U, ARG116W, ARG206U, ARG290W, ARG372W, ARG39U, ARG62U, ASN111W, ASN280W, ASP211U, ASP244U, ASP286W, ASP288W, ASP51U, CYS285W, CYS374W, GLN246U, GLN41U, GLN49U, GLN59U, GLU107W, GLU167W, GLU205U, GLU207U, GLU241U, GLU57U, GLY168W, GLY245U, GLY42U, GLY46U, GLY48U, GLY63U, HIS173W, HIS371W, HIS40U, ILE136W, ILE165W, ILE175W, ILE208U, ILE282W, ILE287W, ILE289W, ILE64U, LEU110W, LEU140W, LEU171W, LEU242U, LEU320W, LEU65U, LEU67U, LYS284W, LYS291W, LYS373W, LYS50U, LYS61U, MET283W, MET325W, MET355W, MET44U, MET47U, PHE375W, PRO109W, PRO164W, PRO172W, PRO243U, PRO322W, SER323W, SER60U, THR148W, THR149W, THR202U, THR203U, THR324W, THR351W, TYR133W, TYR143W, TYR166W, TYR169W, TYR240U, TYR279W, TYR294W, TYR53U, VAL134W, VAL139W, VAL163W, VAL201U, VAL209U, VAL370W, VAL43U, VAL45U
• V-W: ALA108W, ALA114W, ALA174W, ALA204V, ALA228V, ALA230V, ALA231V, ALA272W, ALA365W, ALA58V, ARG116W, ARG177W, ARG183V, ARG183W, ARG196V, ARG206V, ARG254V, ARG256V, ARG256W, ARG312W, ARG37V, ARG39V, ARG62V, ASN111W, ASN115W, ASN252V, ASN280W, ASN78W, ASP179W, ASP184V, ASP184W, ASP187V, ASP286W, CYS285W, GLN121W, GLN246V, GLN263W, GLN41V, GLU117W, GLU195V, GLU195W, GLU207V, GLU224V, GLU224W, GLU237V, GLU253V, GLU259W, GLU270V, GLU270W, GLU276W, GLU72W, GLY158W, GLY197V, GLY251V, GLY268V, GLY268W, GLY273W, GLY366W, GLY36V, GLY42V, GLY63V, GLY74W, HIS161W, HIS173W, HIS275W, HIS371W, HIS40V, ILE175W, ILE192V, ILE192W, ILE248V, ILE267V, ILE267W, ILE287W, ILE34V, ILE369W, ILE64V, ILE75W, ILE76W, LEU110W, LEU171W, LEU178W, LEU180V, LEU180W, LEU193V, LEU65V, LEU67V, LYS113W, LYS118W, LYS191V, LYS191W, LYS284W, LYS61V, LYS68V, MET176W, MET190V, MET227V, MET227W, MET269V, MET269W, MET44V, MET47V, PHE200V, PHE223V, PHE223W, PHE255V, PHE266W, PRO109W, PRO112W, PRO172W, PRO264V, PRO264W, PRO367W, PRO38V, SER199V, SER232V, SER233V, SER234V, SER265V, SER265W, SER271V, SER271W, SER368W, THR194V, THR202V, THR203V, THR229V, THR249V, THR260W, THR66V, THR77W, TRP79W, TYR188V, TYR198V, VAL159W, VAL201V, VAL247V, VAL43V
• V-X: ALA108X, ALA135X, ALA138X, ALA170X, ALA174X, ALA204V, ALA321X, ALA58V, ARG116X, ARG206V, ARG290X, ARG372X, ARG62V, ASN111X, ASN280X, ASP211V, ASP244V, ASP286X, ASP288X, ASP51V, CYS285X, CYS374X, GLN246V, GLN41V, GLN49V, GLN59V, GLU107X, GLU167X, GLU205V, GLU207V, GLU241V, GLU57V, GLY168X, GLY245V, GLY42V, GLY46V, GLY48V, GLY63V, HIS173X, HIS371X, HIS40V, ILE136X, ILE165X, ILE175X, ILE208V, ILE282X, ILE287X, ILE289X, ILE64V, LEU110X, LEU171X, LEU242V, LEU320X, LEU65V, LEU67V, LYS113X, LYS284X, LYS291X, LYS373X, LYS50V, LYS61V, MET283X, MET325X, MET355X, MET44V, MET47V, PHE200V, PHE375X, PRO109X, PRO164X, PRO172X, PRO243V, PRO322X, SER281X, SER323X, SER52V, SER60V, THR149X, THR202V, THR203V, THR324X, THR351X, TYR133X, TYR166X, TYR169X, TYR198V, TYR240V, TYR279X, TYR294X, TYR53V, VAL134X, VAL139X, VAL163X, VAL201V, VAL209V, VAL370X, VAL43V, VAL45V
• W-X: ALA108X, ALA114X, ALA174X, ALA204W, ALA228W, ALA230W, ALA231W, ALA272X, ALA365X, ALA58W, ARG116X, ARG177X, ARG183W, ARG183X, ARG196W, ARG206W, ARG256W, ARG256X, ARG312X, ARG37W, ARG39W, ARG62W, ASN111X, ASN115X, ASN252W, ASN280X, ASN78X, ASP179X, ASP184W, ASP184X, ASP187W, ASP286X, CYS285X, GLN246W, GLN263X, GLN41W, GLU107X, GLU117X, GLU195W, GLU195X, GLU207W, GLU224W, GLU224X, GLU237W, GLU253W, GLU259X, GLU270W, GLU270X, GLU276X, GLU72X, GLY158X, GLY197W, GLY251W, GLY268W, GLY268X, GLY273X, GLY366X, GLY36W, GLY42W, GLY63W, GLY74X, HIS173X, HIS371X, HIS40W, ILE175X, ILE192W, ILE192X, ILE248W, ILE267W, ILE267X, ILE287X, ILE34W, ILE369X, ILE64W, ILE75X, ILE76X, LEU110X, LEU178X, LEU180W, LEU180X, LEU193W, LEU65W, LEU67W, LYS113X, LYS118X, LYS191W, LYS191X, LYS284X, LYS61W, LYS68W, MET176X, MET190W, MET227W, MET227X, MET269W, MET269X, PHE200W, PHE223W, PHE223X, PHE255W, PHE266W, PHE266X, PRO109X, PRO112X, PRO172X, PRO264W, PRO264X, PRO367X, PRO38W, SER199W, SER232W, SER265W, SER265X, SER271W, SER271X, SER368X, THR194W, THR202W, THR203W, THR249W, THR260X, THR66W, THR77X, TRP79X, TYR188W, TYR198W, VAL159X, VAL201W, VAL247W, VAL43W
• W-Y: ALA108Y, ALA135Y, ALA138Y, ALA170Y, ALA174Y, ALA204W, ALA321Y, ALA58W, ARG116Y, ARG206W, ARG290Y, ARG372Y, ARG39W, ARG62W, ASN111Y, ASN280Y, ASP211W, ASP244W, ASP286Y, ASP288Y, ASP51W, CYS285Y, CYS374Y, GLN137Y, GLN246W, GLN41W, GLN49W, GLN59W, GLU107Y, GLU167Y, GLU205W, GLU207W, GLU241W, GLU57W, GLY168Y, GLY245W, GLY42W, GLY46W, GLY48W, GLY63W, HIS173Y, HIS371Y, HIS40W, ILE136Y, ILE165Y, ILE175Y, ILE208W, ILE282Y, ILE287Y, ILE289Y, ILE64W, LEU110Y, LEU140Y, LEU171Y, LEU242W, LEU320Y, LEU65W, LEU67W, LYS113Y, LYS284Y, LYS291Y, LYS373Y, LYS50W, LYS61W, MET283Y, MET325Y, MET355Y, MET44W, MET47W, PHE200W, PHE375Y, PRO109Y, PRO164Y, PRO172Y, PRO243W, PRO322Y, SER281Y, SER323Y, SER60W, THR148Y, THR149Y, THR202W, THR203W, THR324Y, THR351Y, TYR133Y, TYR166Y, TYR169Y, TYR198W, TYR240W, TYR279Y, TYR294Y, TYR53W, VAL134Y, VAL139Y, VAL163Y, VAL201W, VAL209W, VAL370Y, VAL43W, VAL45W
• X-Y: ALA108Y, ALA114Y, ALA174Y, ALA204X, ALA228X, ALA230X, ALA231X, ALA272Y, ALA365Y, ALA58X, ARG116Y, ARG177Y, ARG183X, ARG183Y, ARG196X, ARG206X, ARG256X, ARG256Y, ARG312Y, ARG37X, ARG39X, ARG62X, ASN111Y, ASN115Y, ASN252X, ASN280Y, ASN78Y, ASP179Y, ASP184X, ASP184Y, ASP187X, ASP286Y, CYS285Y, GLN121Y, GLN246X, GLN263Y, GLN41X, GLU107Y, GLU117Y, GLU195X, GLU195Y, GLU205X, GLU207X, GLU224X, GLU224Y, GLU237X, GLU253X, GLU259Y, GLU270X, GLU270Y, GLU276Y, GLU72Y, GLY158Y, GLY197X, GLY251X, GLY268X, GLY268Y, GLY273Y, GLY366Y, GLY36X, GLY42X, GLY63X, GLY74Y, HIS161Y, HIS173Y, HIS371Y, HIS40X, ILE175Y, ILE192X, ILE248X, ILE250X, ILE267X, ILE267Y, ILE287Y, ILE369Y, ILE64X, ILE75Y, ILE76Y, LEU110Y, LEU178Y, LEU180X, LEU180Y, LEU193X, LEU65X, LEU67X, LYS113Y, LYS118Y, LYS191X, LYS191Y, LYS284Y, LYS61X, LYS68X, MET176Y, MET190X, MET227X, MET227Y, MET269X, MET269Y, PHE200X, PHE223X, PHE223Y, PHE255X, PHE262Y, PHE266Y, PRO109Y, PRO112Y, PRO172Y, PRO264X, PRO264Y, PRO367Y, PRO38X, SER199X, SER232X, SER233X, SER234X, SER265X, SER265Y, SER271X, SER271Y, SER368Y, THR194X, THR202X, THR203X, THR249X, THR260Y, THR66X, THR77Y, TRP79Y, TYR188X, TYR198X, VAL159Y, VAL201X, VAL247X, VAL43X
• X-Z: ALA108Z, ALA135Z, ALA138Z, ALA170Z, ALA174Z, ALA204X, ALA321Z, ALA58X, ARG116Z, ARG206X, ARG290Z, ARG372Z, ARG39X, ARG62X, ASN111Z, ASN280Z, ASP244X, ASP286Z, ASP288Z, ASP51X, CYS285Z, CYS374Z, GLN137Z, GLN246X, GLN41X, GLN49X, GLN59X, GLU107Z, GLU167Z, GLU205X, GLU207X, GLU241X, GLU57X, GLY168Z, GLY245X, GLY42X, GLY46X, GLY48X, GLY63X, HIS173Z, HIS371Z, HIS40X, ILE136Z, ILE165Z, ILE175Z, ILE208X, ILE282Z, ILE287Z, ILE289Z, ILE64X, LEU110Z, LEU140Z, LEU171Z, LEU242X, LEU320Z, LEU65X, LYS284Z, LYS291Z, LYS373Z, LYS50X, LYS61X, MET283Z, MET325Z, MET355Z, MET44X, MET47X, PHE200X, PHE375Z, PRO109Z, PRO164Z, PRO172Z, PRO243X, PRO322Z, SER323Z, SER52X, SER60X, THR148Z, THR149Z, THR202X, THR203X, THR324Z, THR351Z, TYR133Z, TYR143Z, TYR166Z, TYR169Z, TYR240X, TYR279Z, TYR294Z, TYR53X, VAL134Z, VAL139Z, VAL163Z, VAL201X, VAL370Z, VAL43X, VAL45X
• Y-Z: ALA108Z, ALA114Z, ALA174Z, ALA204Y, ALA228Y, ALA230Y, ALA231Y, ALA272Z, ALA365Z, ALA58Y, ARG116Z, ARG177Z, ARG183Y, ARG183Z, ARG196Y, ARG206Y, ARG256Y, ARG256Z, ARG37Y, ARG39Y, ARG62Y, ASN111Z, ASN115Z, ASN252Y, ASN280Z, ASN78Z, ASP179Z, ASP184Y, ASP184Z, ASP187Y, ASP286Z, GLN121Z, GLN246Y, GLN263Z, GLN41Y, GLU117Z, GLU195Y, GLU195Z, GLU205Y, GLU207Y, GLU224Y, GLU224Z, GLU226Y, GLU237Y, GLU253Y, GLU259Z, GLU270Y, GLU270Z, GLU276Z, GLU72Z, GLY158Z, GLY197Y, GLY251Y, GLY268Y, GLY268Z, GLY273Z, GLY366Z, GLY36Y, GLY42Y, GLY63Y, GLY74Z, HIS173Z, HIS275Z, HIS371Z, HIS40Y, ILE175Z, ILE192Y, ILE192Z, ILE248Y, ILE267Y, ILE267Z, ILE287Z, ILE34Y, ILE369Z, ILE64Y, ILE75Z, ILE76Z, LEU110Z, LEU178Z, LEU180Y, LEU180Z, LEU193Y, LEU65Y, LEU67Y, LYS113Z, LYS118Z, LYS191Y, LYS191Z, LYS284Z, LYS61Y, LYS68Y, MET176Z, MET190Y, MET227Y, MET227Z, MET269Y, MET269Z, PHE200Y, PHE223Y, PHE223Z, PHE255Y, PHE266Z, PRO109Z, PRO112Z, PRO172Z, PRO264Y, PRO264Z, PRO367Z, PRO38Y, SER199Y, SER232Y, SER234Y, SER265Y, SER265Z, SER271Y, SER271Z, SER368Z, THR194Y, THR202Y, THR203Y, THR249Y, THR260Z, THR66Y, THR77Z, TYR188Y, TYR198Y, VAL159Z, VAL201Y, VAL247Y, VAL43Y