3FXG

crystal structure of rhamnonate dehydratase from gibberella zeae complexed with mg

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 164
  • Norm. En. per Res.: -4.891
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-95.8565	-205.9804	-686.587	-988.4239	220	21	16	26811	16	68	57
A-C	-111.9157	-137.6948	-552.518	-802.1285	164	23	13	20015	8	52	57
A-D	-15.5455	-45.105	-119.467	-180.1175	88	9	0	5376	5	25	43
A-E	-7.0482	-11.0265	-118.777	-136.8517	87	3	0	5331	6	25	42
B-C	-20.1336	-52.3937	-126.966	-199.4933	85	7	0	5532	6	25	44
B-E	-105.5592	-131.2469	-563.507	-800.3131	167	25	13	20550	8	52	57
B-F	-11.8258	-8.9469	-123.372	-144.1446	86	5	0	5373	5	25	43
C-D	-107.9866	-207.7589	-693.732	-1009.4775	219	17	16	27017	16	68	57
C-G	-22.8068	-45.7536	-121.458	-190.0184	88	5	0	5384	5	25	44
D-G	-116.7265	-138.0653	-543.765	-798.5568	165	23	13	19878	8	51	57
D-H	-13.9025	-56.0106	-118.303	-188.2162	87	8	0	5362	5	25	43
E-F	-98.6868	-203.1102	-687.02	-988.8169	213	16	16	26745	14	66	55
E-H	-19.9539	-10.606	-117.946	-148.5058	85	5	0	5227	5	25	43
F-G	-12.1983	-8.9254	-121.544	-142.6677	87	7	0	5491	6	26	44
F-H	-125.5166	-139.7933	-534.443	-799.7529	165	26	13	19695	8	52	57
G-H	-105.826	-208.87	-690.929	-1005.6249	215	18	16	26784	16	66	55

Interface residues

• A-B: ALA103A, ALA118A, ALA118B, ALA130A, ALA130B, ALA394A, ALA394B, ALA45A, ALA45B, ALA88A, ALA88B, ARG117A, ARG117B, ARG124A, ARG124B, ARG279A, ARG279B, ARG283A, ARG283B, ARG55A, ARG55B, ARG98A, ARG98B, ASN109A, ASN109B, ASN227A, ASN227B, ASN61A, ASN61B, ASP192A, ASP192B, ASP253A, ASP253B, ASP254A, ASP254B, ASP256A, ASP256B, ASP26A, ASP26B, ASP400A, ASP400B, CYS190A, CYS190B, CYS89A, GLN114A, GLN114B, GLN50A, GLN50B, GLN94A, GLN94B, GLU113A, GLU113B, GLU248A, GLU248B, GLU274A, GLU274B, GLU276A, GLU276B, GLU287A, GLU287B, GLU407A, GLU407B, GLU49A, GLU49B, GLU97A, GLU97B, GLY123A, GLY123B, GLY126A, GLY126B, GLY19A, GLY19B, GLY20A, GLY20B, GLY257A, GLY257B, GLY273A, GLY273B, GLY281A, GLY281B, GLY59A, GLY59B, GLY64A, GLY64B, GLY84A, GLY84B, GLY85A, GLY85B, HIS275A, HIS275B, HIS28A, HIS28B, HIS93A, HIS93B, HIS95A, HIS95B, ILE101A, ILE129A, ILE129B, ILE17A, ILE17B, ILE397A, ILE397B, ILE60A, ILE60B, LEU100A, LEU100B, LEU110A, LEU110B, LEU111A, LEU111B, LEU127A, LEU127B, LEU226A, LEU226B, LEU250A, LEU250B, LEU260A, LEU260B, LEU285A, LEU285B, LEU396A, LEU396B, LEU402A, LEU402B, LEU63A, LEU63B, LEU91A, LEU91B, LYS125A, LYS125B, LYS284A, LYS284B, LYS395A, LYS395B, LYS404A, LYS404B, LYS47A, LYS47B, PHE112A, PHE112B, PHE121A, PHE121B, PHE258A, PHE258B, PHE403A, PHE403B, PHE83A, PHE83B, PHE96A, PHE96B, PHE99A, PHE99B, PRO128A, PRO128B, PRO191A, PRO191B, PRO252A, PRO252B, PRO398A, PRO398B, PRO406A, PRO406B, PRO44A, PRO44B, PRO86A, PRO86B, PRO87A, PRO87B, SER119A, SER119B, SER225A, SER225B, SER251A, SER251B, SER278A, SER278B, SER399A, SER399B, SER46A, SER46B, SER54B, SER57A, SER57B, THR255A, THR255B, THR43A, THR43B, THR56A, THR56B, TRP300A, TRP300B, TRP48A, TRP48B, TRP58A, TRP58B, TRP90A, TRP90B, TYR116A, TYR116B, TYR122A, TYR122B, TYR223A, TYR223B, TYR277A, TYR277B, TYR27A, TYR27B, TYR280A, TYR280B, TYR401A, TYR401B, TYR51A, TYR51B, VAL131A, VAL131B, VAL405A, VAL405B, VAL62A, VAL62B
• A-C: ALA103A, ALA103C, ALA158A, ALA158C, ALA311A, ALA311C, ALA312A, ALA312C, ALA314A, ALA314C, ALA315A, ALA315C, ALA316A, ALA316C, ALA377A, ALA377C, ARG106A, ARG106C, ARG117A, ARG117C, ARG147A, ARG147C, ARG153A, ARG153C, ARG279A, ARG279C, ARG283A, ARG283C, ARG289A, ARG289C, ASN107A, ASN107C, ASN109A, ASN109C, ASN148A, ASN148C, ASN339A, ASN339C, ASP104A, ASP104C, ASP318A, ASP318C, ASP378C, ASP380A, ASP380C, ASP6A, ASP6C, GLN114A, GLN114C, GLN337A, GLN337C, GLU113A, GLU113C, GLU149A, GLU149C, GLU161A, GLU161C, GLU287A, GLU287C, GLU306A, GLU306C, GLY144A, GLY144C, GLY156A, GLY156C, GLY157A, GLY157C, GLY281A, GLY281C, GLY288C, GLY383A, GLY383C, GLY385A, GLY385C, HIS332A, HIS332C, ILE155A, ILE155C, ILE335A, ILE335C, LEU110A, LEU110C, LEU111A, LEU111C, LEU143A, LEU143C, LEU154A, LEU154C, LEU1A, LEU285A, LEU307A, LEU307C, LEU308A, LEU308C, LEU313A, LEU313C, LEU379A, LEU379C, LYS145A, LYS145C, LYS160A, LYS160C, LYS284A, LYS284C, LYS309A, LYS309C, LYS381A, LYS381C, LYS5A, LYS5C, LYS9A, LYS9C, PHE112A, PHE112C, PHE282A, PHE282C, PHE333A, PHE333C, PHE7A, PHE7C, PRO105A, PRO105C, PRO150A, PRO150C, PRO338A, PRO338C, PRO382A, PRO382C, SER278A, SER278C, SER2A, SER336A, SER336C, SER3A, SER3C, THR108A, THR108C, THR159A, THR159C, THR305A, THR305C, THR340A, THR376A, THR376C, TRP140A, TRP140C, TYR152A, TYR152C, TYR280A, TYR280C, TYR317A, TYR317C, VAL146A, VAL146C, VAL151A, VAL151C, VAL286A, VAL286C, VAL310A, VAL310C, VAL319A, VAL319C, VAL4A, VAL4C
• A-D: ALA237D, ALA259A, ALA259D, ALA264A, ALA264D, ALA316A, ARG199D, ARG209A, ARG263A, ARG263D, ARG289A, ASN227D, ASN242A, ASN244A, ASN290A, ASN339A, ASP164A, ASP192D, ASP215A, ASP240A, ASP253D, ASP254D, ASP256D, ASP292A, ASP318A, GLN337A, GLN50D, GLU161A, GLU196D, GLU233D, GLY182A, GLY194D, GLY257D, GLY288A, HIS195D, HIS265A, HIS265D, ILE218A, ILE232D, ILE243A, ILE261A, ILE261D, ILE293A, LEU198D, LEU226D, LEU239A, LEU239D, LEU250D, LEU260A, LEU260D, LEU291A, LYS160A, LYS236D, LYS262A, LYS262D, LYS269A, LYS47D, PHE216A, PHE258A, PHE258D, PHE270A, PHE342A, PRO191D, PRO214A, PRO217A, PRO266A, PRO266D, PRO320A, PRO338A, PRO341A, SER229D, SER251D, THR159A, THR255D, THR267A, THR271A, THR340A, TRP181A, TRP245A, TRP48D, TYR230D, TYR317A, VAL228D, VAL235A, VAL235D, VAL268A, VAL286A, VAL319A
• A-E: ALA237A, ALA259A, ALA259E, ALA264A, ALA264E, ALA316E, ARG199A, ARG209E, ARG263A, ARG263E, ARG289E, ASN227A, ASN242E, ASN244E, ASN290E, ASN339E, ASP192A, ASP215E, ASP240E, ASP253A, ASP254A, ASP256A, ASP292E, ASP318E, GLN337E, GLU161E, GLU196A, GLU233A, GLU287E, GLY182E, GLY194A, GLY257A, GLY288E, HIS195A, HIS265A, HIS265E, ILE218E, ILE232A, ILE243E, ILE261A, ILE261E, ILE293E, LEU198A, LEU226A, LEU234A, LEU239A, LEU239E, LEU250A, LEU260A, LEU260E, LEU291E, LYS160E, LYS236A, LYS262A, LYS262E, LYS269E, LYS47A, PHE216E, PHE258A, PHE258E, PHE270E, PHE342E, PRO214E, PRO217E, PRO266A, PRO266E, PRO320E, PRO338E, PRO341E, SER229A, SER251A, THR159E, THR255A, THR267E, THR271E, THR340E, TRP181E, TRP245E, TRP48A, TYR230A, TYR317E, VAL228A, VAL235A, VAL235E, VAL268E, VAL286E, VAL319E
• B-C: ALA237B, ALA259B, ALA259C, ALA264B, ALA264C, ALA316C, ARG199B, ARG209C, ARG263B, ARG263C, ARG289C, ASN227B, ASN242C, ASN244C, ASN290C, ASN339C, ASP192B, ASP215C, ASP240C, ASP253B, ASP254B, ASP256B, ASP292C, ASP318C, GLN337C, GLU161C, GLU196B, GLU233B, GLU287C, GLY182C, GLY194B, GLY257B, GLY288C, HIS195B, HIS265B, HIS265C, ILE218C, ILE232B, ILE243C, ILE261B, ILE261C, ILE293C, LEU198B, LEU226B, LEU239B, LEU239C, LEU250B, LEU260B, LEU260C, LEU291C, LYS160C, LYS236B, LYS262B, LYS262C, LYS269C, LYS47B, PHE216C, PHE258B, PHE258C, PHE270C, PHE342C, PRO214C, PRO217C, PRO266B, PRO266C, PRO320C, PRO338C, PRO341C, SER229B, SER251B, THR159C, THR255B, THR267C, THR340C, TRP181C, TRP245C, TRP48B, TYR230B, TYR317C, VAL228B, VAL235B, VAL235C, VAL268C, VAL286C, VAL319C
• B-E: ALA103B, ALA103E, ALA158B, ALA158E, ALA311B, ALA311E, ALA312B, ALA312E, ALA314B, ALA314E, ALA315B, ALA315E, ALA316B, ALA316E, ALA377B, ALA377E, ARG106B, ARG106E, ARG117B, ARG117E, ARG147B, ARG147E, ARG153B, ARG153E, ARG279B, ARG279E, ARG283B, ARG283E, ARG289B, ARG289E, ASN107B, ASN107E, ASN109B, ASN109E, ASN148B, ASN148E, ASN339B, ASN339E, ASP104B, ASP104E, ASP318B, ASP318E, ASP378B, ASP380B, ASP380E, ASP6B, ASP6E, GLN114B, GLN114E, GLN337B, GLN337E, GLU113B, GLU113E, GLU149B, GLU149E, GLU161B, GLU161E, GLU287B, GLU287E, GLU306B, GLU306E, GLY144B, GLY144E, GLY156B, GLY156E, GLY157B, GLY157E, GLY281B, GLY281E, GLY288B, GLY288E, GLY383B, GLY383E, GLY385B, GLY385E, HIS332B, HIS332E, ILE155B, ILE155E, ILE335B, ILE335E, LEU110B, LEU110E, LEU111B, LEU111E, LEU143B, LEU143E, LEU154B, LEU154E, LEU1E, LEU285E, LEU307B, LEU307E, LEU308B, LEU308E, LEU313B, LEU313E, LEU379B, LEU379E, LYS145B, LYS145E, LYS160B, LYS160E, LYS284B, LYS284E, LYS309B, LYS309E, LYS381B, LYS381E, LYS5B, LYS5E, LYS9B, LYS9E, PHE112B, PHE112E, PHE282B, PHE282E, PHE333B, PHE333E, PHE7B, PHE7E, PRO105B, PRO105E, PRO150B, PRO150E, PRO338B, PRO338E, PRO382B, PRO382E, SER278B, SER278E, SER2B, SER2E, SER336B, SER336E, SER3B, SER3E, THR108B, THR108E, THR159B, THR159E, THR305B, THR305E, THR340E, THR375B, THR376B, THR376E, TRP140B, TRP140E, TYR152B, TYR152E, TYR280B, TYR280E, TYR317B, TYR317E, VAL146B, VAL146E, VAL151B, VAL151E, VAL286B, VAL286E, VAL310B, VAL310E, VAL319B, VAL319E, VAL4B, VAL4E
• B-F: ALA237F, ALA259B, ALA259F, ALA264B, ALA264F, ALA316B, ARG199F, ARG209B, ARG263B, ARG263F, ARG289B, ASN227F, ASN242B, ASN244B, ASN290B, ASN339B, ASP164B, ASP192F, ASP215B, ASP240B, ASP253F, ASP254F, ASP256F, ASP292B, ASP318B, GLN337B, GLU161B, GLU196F, GLU233F, GLY182B, GLY194F, GLY257F, GLY288B, HIS195F, HIS265B, HIS265F, ILE218B, ILE232F, ILE243B, ILE261B, ILE261F, ILE293B, LEU198F, LEU226F, LEU239B, LEU239F, LEU250F, LEU260B, LEU260F, LEU291B, LYS160B, LYS236F, LYS262B, LYS262F, LYS269B, LYS47F, PHE216B, PHE258B, PHE258F, PHE270B, PHE342B, PRO191F, PRO214B, PRO217B, PRO266B, PRO266F, PRO320B, PRO338B, PRO341B, SER229F, SER251F, THR159B, THR255F, THR267B, THR340B, TRP181B, TRP245B, TRP48F, TYR230F, TYR317B, VAL228F, VAL235B, VAL235F, VAL268B, VAL286B, VAL319B
• C-D: ALA103D, ALA118C, ALA118D, ALA130C, ALA130D, ALA394C, ALA394D, ALA45C, ALA45D, ALA88C, ALA88D, ARG117C, ARG117D, ARG124C, ARG124D, ARG279C, ARG279D, ARG283C, ARG283D, ARG55C, ARG55D, ARG98C, ARG98D, ASN109C, ASN109D, ASN227C, ASN227D, ASN61C, ASN61D, ASP192C, ASP192D, ASP253C, ASP253D, ASP254C, ASP254D, ASP256C, ASP256D, ASP26C, ASP26D, ASP400C, ASP400D, CYS190C, CYS190D, CYS89C, GLN114C, GLN114D, GLN50C, GLN50D, GLN94C, GLN94D, GLU113C, GLU113D, GLU248C, GLU248D, GLU274C, GLU274D, GLU276C, GLU276D, GLU287C, GLU287D, GLU407C, GLU407D, GLU49C, GLU49D, GLU97C, GLU97D, GLY123C, GLY123D, GLY126C, GLY126D, GLY19C, GLY19D, GLY20C, GLY20D, GLY257C, GLY257D, GLY273C, GLY273D, GLY281C, GLY281D, GLY59C, GLY59D, GLY64C, GLY64D, GLY84C, GLY84D, GLY85C, GLY85D, HIS275C, HIS275D, HIS28C, HIS28D, HIS93C, HIS93D, HIS95C, HIS95D, ILE129C, ILE129D, ILE17C, ILE17D, ILE18D, ILE397C, ILE397D, ILE60C, ILE60D, LEU100C, LEU100D, LEU110C, LEU110D, LEU111C, LEU111D, LEU127C, LEU127D, LEU226C, LEU226D, LEU250C, LEU250D, LEU260C, LEU260D, LEU285C, LEU285D, LEU396C, LEU396D, LEU402C, LEU402D, LEU63C, LEU63D, LEU91C, LEU91D, LYS125C, LYS125D, LYS284C, LYS284D, LYS395C, LYS395D, LYS404C, LYS404D, LYS47C, LYS47D, PHE112C, PHE112D, PHE121C, PHE121D, PHE258C, PHE258D, PHE403C, PHE403D, PHE83C, PHE83D, PHE96C, PHE96D, PHE99C, PHE99D, PRO128C, PRO128D, PRO191C, PRO191D, PRO252C, PRO252D, PRO398C, PRO398D, PRO406C, PRO406D, PRO44C, PRO44D, PRO86C, PRO86D, PRO87C, PRO87D, SER119C, SER119D, SER225C, SER225D, SER251C, SER251D, SER278C, SER278D, SER399C, SER399D, SER46C, SER46D, SER57C, SER57D, THR255C, THR255D, THR43C, THR43D, THR56C, THR56D, TRP300C, TRP300D, TRP48C, TRP48D, TRP58C, TRP58D, TRP90C, TRP90D, TYR116C, TYR116D, TYR122C, TYR122D, TYR223C, TYR223D, TYR277C, TYR277D, TYR27C, TYR27D, TYR280C, TYR280D, TYR401C, TYR401D, TYR51C, TYR51D, VAL131C, VAL131D, VAL405C, VAL405D, VAL62C, VAL62D
• C-G: ALA237C, ALA259C, ALA259G, ALA264C, ALA264G, ALA316G, ARG199C, ARG209G, ARG263C, ARG263G, ARG289G, ASN227C, ASN242G, ASN244G, ASN290G, ASN339G, ASP192C, ASP215G, ASP240G, ASP253C, ASP254C, ASP256C, ASP292G, ASP318G, GLN337G, GLU161G, GLU196C, GLU233C, GLU287G, GLU49C, GLY182G, GLY194C, GLY257C, GLY288G, HIS195C, HIS265C, HIS265G, ILE218G, ILE232C, ILE243G, ILE261C, ILE261G, ILE293G, LEU198C, LEU226C, LEU234C, LEU239C, LEU239G, LEU250C, LEU260C, LEU260G, LEU291G, LYS160G, LYS236C, LYS262C, LYS262G, LYS269G, LYS47C, PHE216G, PHE258C, PHE258G, PHE270G, PHE342G, PRO191C, PRO214G, PRO217G, PRO266C, PRO266G, PRO320G, PRO338G, PRO341G, SER229C, SER251C, THR159G, THR255C, THR267G, THR340G, TRP181G, TRP245G, TRP48C, TYR230C, TYR317G, VAL228C, VAL235C, VAL235G, VAL268G, VAL286G, VAL319G
• D-G: ALA103D, ALA103G, ALA158D, ALA158G, ALA311D, ALA311G, ALA312D, ALA312G, ALA314D, ALA314G, ALA315D, ALA315G, ALA316D, ALA316G, ALA377D, ALA377G, ARG106D, ARG106G, ARG117D, ARG117G, ARG147D, ARG147G, ARG153D, ARG153G, ARG279D, ARG279G, ARG283D, ARG283G, ARG289D, ARG289G, ASN107D, ASN107G, ASN109D, ASN109G, ASN148D, ASN148G, ASN339D, ASN339G, ASP104D, ASP104G, ASP318D, ASP318G, ASP378D, ASP380D, ASP380G, ASP6D, ASP6G, GLN114D, GLN114G, GLN337D, GLN337G, GLU113D, GLU113G, GLU149D, GLU149G, GLU161D, GLU161G, GLU287D, GLU287G, GLU306D, GLU306G, GLY144D, GLY144G, GLY156D, GLY156G, GLY157D, GLY157G, GLY281D, GLY281G, GLY288D, GLY288G, GLY383D, GLY383G, GLY385D, GLY385G, HIS332D, HIS332G, ILE155D, ILE155G, ILE335D, ILE335G, LEU110D, LEU110G, LEU111D, LEU111G, LEU143D, LEU143G, LEU154D, LEU154G, LEU1G, LEU285D, LEU307D, LEU307G, LEU308D, LEU308G, LEU313D, LEU313G, LEU379D, LEU379G, LYS145D, LYS145G, LYS160D, LYS160G, LYS284D, LYS284G, LYS309D, LYS309G, LYS381D, LYS381G, LYS5D, LYS5G, LYS9D, LYS9G, PHE112D, PHE112G, PHE282D, PHE282G, PHE333D, PHE333G, PHE7D, PHE7G, PRO105D, PRO105G, PRO150D, PRO150G, PRO338D, PRO338G, PRO382D, PRO382G, SER278D, SER278G, SER2G, SER336D, SER336G, SER3D, SER3G, THR108D, THR108G, THR159D, THR159G, THR305D, THR305G, THR340D, THR376D, THR376G, TRP140D, TRP140G, TYR152D, TYR152G, TYR280D, TYR280G, TYR317D, TYR317G, VAL146D, VAL146G, VAL151D, VAL151G, VAL286D, VAL286G, VAL310D, VAL310G, VAL319D, VAL319G, VAL4D, VAL4G
• D-H: ALA237H, ALA259D, ALA259H, ALA264D, ALA264H, ALA316D, ARG199H, ARG209D, ARG263D, ARG263H, ARG289D, ASN227H, ASN242D, ASN244D, ASN290D, ASN339D, ASP192H, ASP215D, ASP240D, ASP253H, ASP254H, ASP256H, ASP292D, ASP318D, GLN337D, GLU161D, GLU196H, GLU233H, GLY182D, GLY194H, GLY257H, GLY288D, HIS195H, HIS265D, HIS265H, ILE218D, ILE232H, ILE243D, ILE261D, ILE261H, ILE293D, LEU198H, LEU226H, LEU234H, LEU239D, LEU239H, LEU250H, LEU260D, LEU260H, LEU291D, LYS160D, LYS176D, LYS236H, LYS262D, LYS262H, LYS269D, LYS47H, PHE216D, PHE258D, PHE258H, PHE270D, PHE342D, PRO214D, PRO217D, PRO266D, PRO266H, PRO320D, PRO338D, PRO341D, SER229H, SER251H, THR159D, THR231H, THR255H, THR267D, THR271D, THR340D, TRP181D, TRP245D, TRP48H, TYR230H, TYR317D, VAL228H, VAL235H, VAL268D, VAL286D, VAL319D
• E-F: ALA103E, ALA118E, ALA118F, ALA130E, ALA130F, ALA394F, ALA45E, ALA45F, ALA88E, ALA88F, ARG117E, ARG117F, ARG124E, ARG124F, ARG279E, ARG279F, ARG283E, ARG283F, ARG55E, ARG55F, ARG98E, ARG98F, ASN109E, ASN109F, ASN227E, ASN227F, ASN61E, ASN61F, ASP192E, ASP192F, ASP253E, ASP253F, ASP254E, ASP254F, ASP256E, ASP256F, ASP26E, ASP26F, ASP400E, ASP400F, CYS190E, CYS190F, GLN114E, GLN114F, GLN50E, GLN50F, GLN94E, GLN94F, GLU113E, GLU113F, GLU248E, GLU248F, GLU274E, GLU274F, GLU276E, GLU276F, GLU287E, GLU287F, GLU407E, GLU49E, GLU49F, GLU97E, GLU97F, GLY123E, GLY123F, GLY126E, GLY126F, GLY19E, GLY19F, GLY20E, GLY20F, GLY257E, GLY257F, GLY273E, GLY273F, GLY281E, GLY281F, GLY59E, GLY59F, GLY64E, GLY64F, GLY84E, GLY84F, GLY85E, GLY85F, HIS275E, HIS275F, HIS28E, HIS28F, HIS93E, HIS93F, HIS95E, HIS95F, ILE129E, ILE129F, ILE17E, ILE17F, ILE397E, ILE397F, ILE60E, ILE60F, LEU100E, LEU100F, LEU110E, LEU110F, LEU111E, LEU111F, LEU127E, LEU127F, LEU226E, LEU226F, LEU250E, LEU250F, LEU260E, LEU260F, LEU285E, LEU285F, LEU396E, LEU396F, LEU402E, LEU402F, LEU63E, LEU63F, LEU91E, LEU91F, LYS125E, LYS125F, LYS284E, LYS284F, LYS395F, LYS404E, LYS404F, LYS47E, LYS47F, PHE112E, PHE112F, PHE121E, PHE121F, PHE258E, PHE258F, PHE403E, PHE403F, PHE83E, PHE83F, PHE96E, PHE96F, PHE99E, PHE99F, PRO128E, PRO128F, PRO191E, PRO191F, PRO252E, PRO252F, PRO398E, PRO398F, PRO406E, PRO406F, PRO44E, PRO44F, PRO86E, PRO86F, PRO87E, PRO87F, SER119E, SER119F, SER225E, SER225F, SER251E, SER251F, SER278E, SER278F, SER399E, SER399F, SER46E, SER46F, SER57E, SER57F, THR255E, THR255F, THR43E, THR43F, THR56E, THR56F, TRP300E, TRP300F, TRP48E, TRP48F, TRP58E, TRP58F, TRP90E, TRP90F, TYR116E, TYR116F, TYR122E, TYR122F, TYR223E, TYR223F, TYR277E, TYR277F, TYR27E, TYR280E, TYR280F, TYR401E, TYR401F, TYR51E, TYR51F, VAL131E, VAL131F, VAL405E, VAL405F, VAL62E, VAL62F
• E-H: ALA237E, ALA259E, ALA259H, ALA264E, ALA264H, ALA316H, ARG199E, ARG209H, ARG263E, ARG263H, ARG289H, ASN227E, ASN242H, ASN244H, ASN290H, ASN339H, ASP192E, ASP215H, ASP253E, ASP254E, ASP256E, ASP292H, ASP318H, GLN337H, GLU161H, GLU196E, GLU233E, GLU287H, GLY182H, GLY194E, GLY257E, GLY288H, HIS195E, HIS265E, HIS265H, ILE218H, ILE232E, ILE243H, ILE261E, ILE261H, ILE293H, LEU198E, LEU226E, LEU234E, LEU239E, LEU239H, LEU250E, LEU260E, LEU260H, LEU291H, LYS160H, LYS236E, LYS262E, LYS262H, LYS269H, LYS47E, PHE216H, PHE258E, PHE258H, PHE270H, PHE342H, PRO191E, PRO214H, PRO217H, PRO266E, PRO266H, PRO320H, PRO338H, PRO341H, SER229E, SER251E, THR159H, THR255E, THR267H, THR340H, TRP181H, TRP245H, TRP48E, TYR230E, TYR317H, VAL228E, VAL235E, VAL268H, VAL286H, VAL319H
• F-G: ALA237G, ALA259F, ALA259G, ALA264F, ALA264G, ALA316F, ARG199G, ARG263F, ARG263G, ARG289F, ASN227G, ASN242F, ASN244F, ASN290F, ASN339F, ASP164F, ASP192G, ASP215F, ASP240F, ASP253G, ASP254G, ASP256G, ASP292F, ASP318F, GLN337F, GLN50G, GLU161F, GLU196G, GLU233G, GLY182F, GLY194G, GLY257G, GLY288F, HIS195G, HIS265F, HIS265G, ILE218F, ILE232G, ILE243F, ILE261F, ILE261G, ILE293F, LEU198G, LEU226G, LEU239F, LEU239G, LEU250G, LEU260F, LEU260G, LEU291F, LYS160F, LYS176F, LYS236G, LYS262F, LYS262G, LYS269F, LYS47G, PHE216F, PHE258F, PHE258G, PHE270F, PHE342F, PRO191G, PRO214F, PRO217F, PRO266F, PRO266G, PRO320F, PRO338F, PRO341F, SER229G, SER251G, THR159F, THR255G, THR267F, THR340F, TRP181F, TRP245F, TRP48G, TYR230G, TYR317F, VAL228G, VAL235F, VAL235G, VAL268F, VAL286F, VAL319F
• F-H: ALA103F, ALA103H, ALA158F, ALA158H, ALA311F, ALA311H, ALA312F, ALA312H, ALA314F, ALA314H, ALA315F, ALA315H, ALA316F, ALA316H, ALA377F, ALA377H, ARG106F, ARG106H, ARG117F, ARG117H, ARG147F, ARG147H, ARG153F, ARG153H, ARG279F, ARG279H, ARG283F, ARG283H, ARG289F, ARG289H, ASN107F, ASN107H, ASN109F, ASN109H, ASN148F, ASN148H, ASN339F, ASN339H, ASP104F, ASP104H, ASP318F, ASP318H, ASP378H, ASP380F, ASP380H, ASP6F, ASP6H, GLN114F, GLN114H, GLN337F, GLN337H, GLU113F, GLU113H, GLU149F, GLU149H, GLU161F, GLU161H, GLU287F, GLU287H, GLU306F, GLU306H, GLY144F, GLY144H, GLY156F, GLY156H, GLY157F, GLY157H, GLY281F, GLY281H, GLY288F, GLY288H, GLY383F, GLY383H, GLY385F, GLY385H, HIS332F, HIS332H, ILE155F, ILE155H, ILE335F, ILE335H, LEU110F, LEU110H, LEU111F, LEU111H, LEU143F, LEU143H, LEU154F, LEU154H, LEU1F, LEU285H, LEU307F, LEU307H, LEU308F, LEU308H, LEU313F, LEU313H, LEU379F, LEU379H, LYS145F, LYS145H, LYS160F, LYS160H, LYS284F, LYS284H, LYS309F, LYS309H, LYS381F, LYS381H, LYS5F, LYS5H, LYS9F, LYS9H, PHE112F, PHE112H, PHE282F, PHE282H, PHE333F, PHE333H, PHE7F, PHE7H, PRO105F, PRO105H, PRO150F, PRO150H, PRO338F, PRO338H, PRO382F, PRO382H, SER278F, SER278H, SER2F, SER336F, SER336H, SER3F, SER3H, THR108F, THR108H, THR159F, THR159H, THR305F, THR305H, THR375H, THR376F, THR376H, TRP140F, TRP140H, TYR152F, TYR152H, TYR280F, TYR280H, TYR317F, TYR317H, VAL146F, VAL146H, VAL151F, VAL151H, VAL286F, VAL286H, VAL310F, VAL310H, VAL319F, VAL319H, VAL4F, VAL4H
• G-H: ALA103G, ALA103H, ALA118G, ALA118H, ALA130G, ALA130H, ALA394G, ALA45G, ALA45H, ALA88G, ALA88H, ARG117G, ARG117H, ARG124G, ARG124H, ARG279G, ARG279H, ARG283G, ARG283H, ARG55G, ARG55H, ARG98G, ARG98H, ASN109G, ASN109H, ASN227G, ASN227H, ASN61G, ASN61H, ASP192G, ASP192H, ASP253G, ASP253H, ASP254G, ASP254H, ASP256G, ASP256H, ASP26G, ASP26H, ASP400G, ASP400H, CYS190G, CYS190H, GLN114G, GLN114H, GLN50G, GLN50H, GLN94G, GLN94H, GLU113G, GLU113H, GLU248G, GLU248H, GLU274G, GLU274H, GLU276G, GLU276H, GLU287G, GLU287H, GLU407H, GLU49G, GLU49H, GLU97G, GLU97H, GLY123G, GLY123H, GLY126G, GLY126H, GLY19G, GLY19H, GLY20G, GLY20H, GLY257G, GLY257H, GLY273G, GLY273H, GLY281G, GLY281H, GLY59G, GLY59H, GLY64G, GLY64H, GLY84G, GLY84H, GLY85G, GLY85H, HIS275G, HIS275H, HIS28G, HIS28H, HIS93G, HIS93H, HIS95G, HIS95H, ILE129G, ILE129H, ILE17G, ILE17H, ILE397G, ILE397H, ILE60G, ILE60H, LEU100G, LEU100H, LEU110G, LEU110H, LEU111G, LEU111H, LEU127G, LEU127H, LEU226G, LEU226H, LEU250G, LEU250H, LEU260G, LEU260H, LEU285G, LEU285H, LEU396G, LEU396H, LEU402G, LEU402H, LEU63G, LEU63H, LEU91G, LEU91H, LYS125G, LYS125H, LYS284G, LYS284H, LYS395G, LYS404G, LYS404H, LYS47G, LYS47H, PHE112G, PHE112H, PHE121G, PHE121H, PHE258G, PHE258H, PHE403G, PHE403H, PHE83G, PHE83H, PHE96G, PHE96H, PHE99G, PHE99H, PRO128G, PRO128H, PRO191G, PRO191H, PRO252G, PRO252H, PRO398G, PRO398H, PRO406G, PRO406H, PRO44G, PRO44H, PRO86G, PRO86H, PRO87G, PRO87H, SER119G, SER119H, SER225G, SER225H, SER251G, SER251H, SER278G, SER278H, SER399G, SER399H, SER46G, SER46H, SER57G, SER57H, THR255G, THR255H, THR43G, THR43H, THR56G, THR56H, TRP300G, TRP300H, TRP48G, TRP48H, TRP58G, TRP58H, TRP90G, TRP90H, TYR116G, TYR116H, TYR122G, TYR122H, TYR223G, TYR223H, TYR277G, TYR277H, TYR27G, TYR27H, TYR280G, TYR280H, TYR401G, TYR401H, TYR51G, TYR51H, VAL131G, VAL131H, VAL405G, VAL405H, VAL62G, VAL62H