3FVT

crystal structure of acetyl xylan esterase from bacillus pumilus, monoclinic crystal form ii

• Total interactions analyzed: 66
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 47
  • Norm. En. per Res.: -4.5976
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-17.4508	-75.2992	-116.605	-209.3549	46	2	1	3866	5	9	9
A-C	-127.1955	2.076	-352.803	-477.9225	117	27	0	11538	0	26	31
A-E	-24.0151	2.1073	-200.741	-222.6489	97	10	3	8784	0	22	28
A-F	-30.4538	-73.9495	-111.683	-216.0863	47	3	1	3908	5	9	10
B-C	-24.5917	1.0663	-203.256	-226.7814	93	8	3	8714	0	21	27
B-D	-138.1518	5.8744	-364.032	-496.3094	116	26	0	11547	0	26	32
B-F	-11.4052	-69.9461	-107.499	-188.8503	43	0	1	3678	5	9	8
C-D	-22.4037	-73.0182	-110.009	-205.4309	45	4	1	3768	5	9	8
C-E	-18.2576	-69.0515	-111.396	-198.7051	45	1	1	3795	5	9	9
C-I	-9.8119	-3.5877	-50.2969	-63.6965	39	4	0	2453	0	22	15
D-E	-16.2228	-73.7183	-113.978	-203.9191	45	4	1	3796	5	9	10
D-F	-28.2306	0.0	-206.231	-234.4616	95	4	3	8801	0	20	27
E-F	-133.7526	4.0094	-327.974	-457.7172	117	40	0	11487	0	26	33
G-H	-14.0005	-77.4942	-106.222	-197.7167	44	2	1	3731	5	9	8
G-I	-19.971	-67.6312	-108.36	-195.9623	43	1	1	3690	5	9	8
G-L	-27.1677	1.1168	-198.991	-225.0419	94	3	3	8719	0	22	28
G-M	-125.2682	4.1627	-338.071	-459.1765	114	26	0	11303	0	26	31
H-I	-13.6139	-73.6707	-105.235	-192.5196	42	0	1	3694	5	9	8
H-M	-12.8747	1.0531	-200.443	-212.2646	91	13	3	8923	0	22	28
H-N	-130.8955	3.8542	-342.079	-469.1202	115	29	0	11443	0	26	34
I-L	-126.9356	2.6765	-333.517	-457.7761	118	36	0	11470	0	26	31
I-N	-28.5809	1.044	-195.212	-222.7489	93	5	3	8619	0	22	28
L-M	-16.1472	-73.966	-115.369	-205.4823	45	2	1	3855	5	9	9
L-N	-21.973	-70.1934	-108.178	-200.3444	45	2	1	3843	5	9	9
M-N	-21.0701	-70.7883	-111.929	-203.7874	46	1	1	3873	5	9	8

Interface residues

• A-B: ALA213A, ALA217A, ALA303B, ARG212A, ARG230A, ARG231A, ARG294B, ASN226A, ASN232A, ASP215A, ASP234A, GLN2B, GLU211A, GLU219A, GLU238A, GLU299B, GLY266B, GLY297B, HIS298B, ILE225A, ILE268B, ILE301B, LEU218A, LEU223A, LEU3B, LYS270B, PHE210A, PHE229A, PHE242A, PHE296B, PHE300B, PHE304B, PHE4A, PHE4B, PRO235A, PRO273A, PRO302B, SER227A, SER233A, THR306B, TYR222A, TYR228A, TYR293B, TYR295B, VAL214A, VAL216A
• A-C: ALA134A, ALA134C, ALA93A, ALA93C, ARG118A, ARG118C, ARG230A, ARG230C, ARG231A, ARG231C, ARG58A, ARG58C, ASN226A, ASN226C, ASN232A, ASN232C, ASN92A, ASN92C, ASP125A, ASP125C, ASP234A, ASP234C, ASP96A, ASP96C, GLN120A, GLN120C, GLN220A, GLN220C, GLU124A, GLU124C, GLU224A, GLU224C, GLU70A, GLU70C, GLY119A, GLY119C, GLY121A, GLY121C, GLY122A, GLY122C, GLY131A, GLY131C, GLY132A, GLY132C, GLY136A, GLY136C, GLY141A, GLY141C, GLY65A, GLY65C, GLY90A, GLY90C, GLY97A, GLY97C, GLY98A, GLY98C, HIS100A, HIS100C, HIS133A, HIS133C, HIS66A, HIS66C, HIS89A, HIS89C, ILE69A, LEU116A, LEU116C, LEU135A, LEU135C, LYS140A, LYS140C, LYS68A, LYS68C, MET138A, MET138C, PHE229A, PHE229C, PRO130A, PRO130C, PRO221A, PRO221C, SER123A, SER123C, SER127A, SER127C, SER227A, SER227C, SER233A, SER233C, SER67A, SER67C, SER94A, SER94C, THR126A, THR126C, THR129A, THR129C, THR139A, THR139C, TRP137A, TRP137C, TYR149A, TYR149C, TYR228A, TYR228C, TYR47A, TYR47C, TYR91A, TYR91C, TYR95A, TYR95C, VAL117A, VAL117C, VAL128A, VAL128C, VAL237A, VAL237C
• A-E: ALA106A, ALA106E, ALA303A, ALA303E, ARG174A, ASN104A, ASN104E, ASP101A, ASP101E, ASP48A, ASP48E, ASP96A, ASP96E, GLN305A, GLN305E, GLN313A, GLN313E, GLN78A, GLN78E, GLU299A, GLU299E, GLU307A, GLU307E, GLY109A, GLY109E, GLY53A, GLY53E, GLY97A, GLY97E, GLY98A, GLY98E, HIS100A, HIS100E, HIS108A, HIS108E, HIS82A, HIS82E, ILE301A, ILE301E, ILE99A, ILE99E, LEU107A, LEU107E, LEU309A, LEU309E, LEU312A, LEU312E, LEU317A, LEU317E, LEU318A, LEU318E, LYS308A, LYS308E, LYS314A, LYS314E, LYS52A, LYS52E, PHE296A, PHE296E, PHE300A, PHE300E, PHE304A, PHE304E, PHE311A, PHE311E, PRO302A, PRO302E, PRO50A, PRO50E, PRO76A, PRO76E, PRO83A, PRO83E, SER310A, SER310E, SER94A, SER94E, THR306A, THR306E, TRP105A, TRP105E, TYR110A, TYR110E, TYR295A, TYR295E, TYR47A, TYR47E, TYR49A, TYR49E, TYR95A, TYR95E, VAL103A, VAL103E, VAL51A, VAL51E, VAL54A, VAL54E
• A-F: ALA213F, ALA217F, ALA241F, ALA303A, ARG212F, ARG230F, ARG231F, ARG294A, ASN226F, ASN232F, ASP215F, ASP234F, GLN220F, GLN2A, GLU211F, GLU219F, GLU238F, GLU299A, GLY266A, GLY297A, HIS298A, ILE225F, ILE268A, ILE301A, LEU218F, LEU223F, LEU3A, MET1A, PHE229F, PHE242F, PHE296A, PHE300A, PHE304A, PHE4A, PHE4F, PRO235F, PRO273F, PRO302A, SER227F, SER233F, THR306A, TYR222F, TYR228F, TYR293A, TYR295A, VAL214F, VAL216F
• B-C: ALA106B, ALA106C, ALA303B, ALA303C, ARG174B, ASN104B, ASN104C, ASP101B, ASP101C, ASP48B, ASP48C, ASP96B, ASP96C, GLN305B, GLN305C, GLN313B, GLN313C, GLN78B, GLU299B, GLU299C, GLU307B, GLU307C, GLY109B, GLY109C, GLY53B, GLY53C, GLY97B, GLY97C, GLY98B, GLY98C, HIS100B, HIS100C, HIS108B, HIS108C, HIS82B, ILE301B, ILE301C, ILE99B, ILE99C, LEU107B, LEU107C, LEU309B, LEU309C, LEU312B, LEU312C, LEU317B, LEU317C, LEU318B, LYS308B, LYS308C, LYS314B, LYS314C, LYS52B, LYS52C, PHE296B, PHE296C, PHE300B, PHE300C, PHE304B, PHE304C, PHE311B, PHE311C, PRO302B, PRO302C, PRO50B, PRO50C, PRO76B, PRO83B, SER310B, SER310C, SER94B, SER94C, THR306B, THR306C, THR79B, TRP105B, TRP105C, TYR110B, TYR110C, TYR295B, TYR295C, TYR47B, TYR47C, TYR49B, TYR49C, TYR95B, TYR95C, VAL103B, VAL103C, VAL51B, VAL51C, VAL54B, VAL54C
• B-D: ALA134B, ALA134D, ALA93B, ALA93D, ARG118B, ARG118D, ARG230B, ARG230D, ARG231B, ARG231D, ARG58B, ARG58D, ASN226B, ASN226D, ASN232B, ASN232D, ASN92B, ASN92D, ASP125B, ASP125D, ASP234B, ASP234D, ASP96B, ASP96D, GLN120B, GLN120D, GLN220B, GLN220D, GLU124B, GLU124D, GLU224B, GLU224D, GLU70B, GLU70D, GLY119B, GLY119D, GLY121B, GLY121D, GLY122B, GLY122D, GLY131B, GLY131D, GLY132B, GLY132D, GLY136B, GLY136D, GLY141B, GLY141D, GLY65B, GLY90B, GLY90D, GLY97B, GLY97D, GLY98B, GLY98D, HIS100B, HIS100D, HIS133B, HIS133D, HIS66B, HIS66D, ILE69B, ILE69D, ILE99B, LEU116B, LEU116D, LEU135B, LEU135D, LYS140B, LYS140D, LYS68B, LYS68D, MET138B, MET138D, PHE229B, PHE229D, PRO130B, PRO130D, PRO221B, PRO221D, SER123B, SER123D, SER127B, SER127D, SER227B, SER227D, SER233B, SER233D, SER67B, SER67D, SER94B, SER94D, THR126B, THR126D, THR129B, THR129D, THR139B, THR139D, TRP137B, TRP137D, TYR149B, TYR149D, TYR228B, TYR228D, TYR47B, TYR47D, TYR91B, TYR91D, TYR95B, TYR95D, VAL117B, VAL117D, VAL128B, VAL128D, VAL237B, VAL237D
• B-F: ALA213B, ALA217B, ALA303F, ARG212B, ARG230B, ARG231B, ARG294F, ASN226B, ASN232B, ASP215B, ASP234B, GLN2F, GLU211B, GLU219B, GLU238B, GLU299F, GLY266F, GLY297F, HIS298F, ILE225B, ILE268F, ILE301F, LEU218B, LEU223B, LEU3F, PHE229B, PHE242B, PHE296F, PHE300F, PHE304F, PHE4B, PRO235B, PRO273B, PRO302F, SER227B, SER233B, THR306F, TYR222B, TYR228B, TYR293F, TYR295F, VAL214B, VAL216B
• C-D: ALA213D, ALA217D, ALA241D, ALA303C, ARG212D, ARG230D, ARG231D, ARG294C, ASN226D, ASN232D, ASP215D, ASP234D, GLN2C, GLU211D, GLU219D, GLU238D, GLU299C, GLY266C, GLY297C, HIS298C, ILE225D, ILE268C, ILE301C, LEU218D, LEU223D, LEU3C, PHE229D, PHE242D, PHE296C, PHE300C, PHE304C, PHE4C, PHE4D, PRO235D, PRO273D, PRO302C, SER227D, SER233D, THR306C, TYR222D, TYR228D, TYR293C, TYR295C, VAL214D, VAL216D
• C-E: ALA213C, ALA217C, ALA303E, ARG212C, ARG230C, ARG231C, ARG294E, ASN226C, ASN232C, ASP215C, ASP234C, GLN2E, GLU211C, GLU219C, GLU238C, GLU299E, GLY266E, GLY297E, HIS298E, ILE225C, ILE268E, ILE301E, LEU218C, LEU223C, LEU3E, PHE210C, PHE229C, PHE242C, PHE296E, PHE300E, PHE304E, PHE4C, PHE4E, PRO235C, PRO273C, PRO302E, SER227C, SER233C, THR306E, TYR222C, TYR228C, TYR293E, TYR295E, VAL214C, VAL216C
• C-I: ALA20I, ALA40C, ARG21I, ARG58C, ASP23I, ASP26I, ASP48C, GLU169C, GLU243I, GLU39C, GLU41C, GLU45C, LEU44C, LEU59C, LYS145I, LYS17I, LYS18I, LYS240I, LYS29I, LYS30I, LYS55C, PHE167C, PHE24I, PHE27I, PRO168C, PRO22I, PRO42C, SER166C, SER25I, SER46C, THR43C, THR60C, TRP256I, TYR47C, TYR57C, TYR61C, TYR73C, VAL163C, VAL56C
• D-E: ALA213E, ALA217E, ALA303D, ARG212E, ARG230E, ARG231E, ARG294D, ASN226E, ASN232E, ASP215E, ASP234E, GLN2D, GLU211E, GLU219E, GLU238E, GLU299D, GLY266D, GLY297D, HIS298D, ILE225E, ILE268D, ILE301D, LEU218E, LEU223E, LEU3D, LYS270D, PHE229E, PHE242E, PHE296D, PHE300D, PHE304D, PHE4D, PHE4E, PRO235E, PRO273E, PRO302D, SER227E, SER233E, THR306D, TYR222E, TYR228E, TYR293D, TYR295D, VAL214E, VAL216E
• D-F: ALA106D, ALA106F, ALA303D, ALA303F, ASN104D, ASN104F, ASP101D, ASP101F, ASP48D, ASP48F, ASP96D, ASP96F, GLN305D, GLN305F, GLN313D, GLN313F, GLN78D, GLN78F, GLU299D, GLU299F, GLU307D, GLU307F, GLY109D, GLY109F, GLY53D, GLY53F, GLY97D, GLY97F, GLY98D, GLY98F, HIS100D, HIS100F, HIS108D, HIS108F, HIS82F, ILE301D, ILE301F, ILE99D, ILE99F, LEU107D, LEU107F, LEU309D, LEU309F, LEU312D, LEU312F, LEU317D, LEU317F, LEU318D, LEU318F, LYS308D, LYS308F, LYS314D, LYS314F, LYS52D, LYS52F, PHE296D, PHE296F, PHE300D, PHE300F, PHE304D, PHE304F, PHE311D, PHE311F, PRO302D, PRO302F, PRO50D, PRO50F, PRO76D, PRO76F, PRO83D, PRO83F, SER310D, SER310F, SER94D, SER94F, THR306D, THR306F, TRP105D, TRP105F, TYR110D, TYR110F, TYR295D, TYR295F, TYR47D, TYR47F, TYR49D, TYR49F, TYR95D, TYR95F, VAL103D, VAL103F, VAL51D, VAL51F, VAL54D, VAL54F
• E-F: ALA134E, ALA134F, ALA93E, ALA93F, ARG118E, ARG118F, ARG230E, ARG230F, ARG231E, ARG231F, ARG58E, ARG58F, ASN226F, ASN232E, ASN232F, ASN92E, ASN92F, ASP125E, ASP125F, ASP234E, ASP234F, ASP96E, ASP96F, GLN120E, GLN120F, GLN220E, GLN220F, GLU124E, GLU124F, GLU224E, GLU224F, GLU70E, GLU70F, GLY119E, GLY119F, GLY121E, GLY121F, GLY122E, GLY122F, GLY131E, GLY131F, GLY132E, GLY132F, GLY136E, GLY136F, GLY141E, GLY141F, GLY65E, GLY65F, GLY90E, GLY90F, GLY97E, GLY97F, GLY98E, GLY98F, HIS100E, HIS100F, HIS133E, HIS133F, HIS66E, HIS66F, HIS89E, HIS89F, ILE69E, ILE69F, ILE99E, LEU116E, LEU116F, LEU135E, LEU135F, LYS140E, LYS140F, LYS68E, LYS68F, MET138E, MET138F, PHE229E, PHE229F, PRO130E, PRO130F, PRO221E, PRO221F, SER123E, SER123F, SER127E, SER127F, SER227E, SER227F, SER233E, SER233F, SER67E, SER67F, SER94E, SER94F, THR126E, THR126F, THR129E, THR129F, THR139E, THR139F, TRP137E, TRP137F, TYR149E, TYR149F, TYR228E, TYR228F, TYR47F, TYR91E, TYR91F, TYR95E, TYR95F, VAL117E, VAL117F, VAL128E, VAL128F, VAL237E, VAL237F
• G-H: ALA213G, ALA217G, ALA303H, ARG212G, ARG230G, ARG231G, ARG294H, ASN226G, ASN232G, ASP215G, ASP234G, GLN2H, GLU211G, GLU219G, GLU238G, GLU299H, GLY266H, GLY297H, HIS298H, ILE225G, ILE268H, ILE301H, LEU218G, LEU223G, LEU3H, PHE210G, PHE229G, PHE242G, PHE296H, PHE300H, PHE304H, PHE4G, PHE4H, PRO235G, PRO273G, PRO302H, SER227G, SER233G, TYR222G, TYR228G, TYR293H, TYR295H, VAL214G, VAL216G
• G-I: ALA213I, ALA217I, ALA303G, ARG212I, ARG230I, ARG231I, ARG294G, ASN226I, ASN232I, ASP215I, ASP234I, GLN2G, GLU211I, GLU219I, GLU238I, GLU299G, GLY266G, GLY297G, HIS298G, ILE225I, ILE268G, ILE301G, LEU218I, LEU223I, LEU3G, PHE229I, PHE242I, PHE296G, PHE300G, PHE304G, PHE4I, PRO235I, PRO273I, PRO302G, SER227I, SER233I, THR306G, TYR222I, TYR228I, TYR293G, TYR295G, VAL214I, VAL216I
• G-L: ALA106G, ALA106L, ALA303G, ALA303L, ARG174L, ASN104G, ASN104L, ASP101G, ASP101L, ASP48G, ASP48L, ASP96G, ASP96L, GLN305G, GLN305L, GLN313G, GLN313L, GLN78G, GLN78L, GLU299G, GLU299L, GLU307G, GLU307L, GLY109G, GLY109L, GLY53G, GLY53L, GLY97G, GLY97L, GLY98G, GLY98L, HIS100G, HIS100L, HIS108G, HIS108L, HIS82L, ILE301G, ILE301L, ILE99G, ILE99L, LEU107G, LEU107L, LEU309G, LEU309L, LEU312G, LEU312L, LEU317G, LEU317L, LEU318G, LEU318L, LYS308G, LYS308L, LYS314G, LYS314L, LYS52G, LYS52L, PHE296G, PHE296L, PHE300G, PHE300L, PHE304G, PHE304L, PHE311G, PHE311L, PRO302G, PRO302L, PRO50G, PRO50L, PRO76L, PRO83G, PRO83L, SER310G, SER310L, SER94G, SER94L, THR306G, THR306L, TRP105G, TRP105L, TYR110G, TYR110L, TYR295G, TYR47G, TYR47L, TYR49G, TYR49L, TYR95G, TYR95L, VAL103G, VAL103L, VAL51G, VAL51L, VAL54G, VAL54L
• G-M: ALA134G, ALA134M, ALA93G, ALA93M, ARG118G, ARG118M, ARG230G, ARG230M, ARG231G, ARG231M, ARG58G, ARG58M, ASN226G, ASN226M, ASN232G, ASN232M, ASN92G, ASN92M, ASP125G, ASP125M, ASP234G, ASP234M, ASP96G, ASP96M, GLN120G, GLN120M, GLN220G, GLN220M, GLU124G, GLU124M, GLU224G, GLU224M, GLU70G, GLU70M, GLY119G, GLY119M, GLY121G, GLY121M, GLY122G, GLY122M, GLY131G, GLY131M, GLY132G, GLY132M, GLY136G, GLY136M, GLY141G, GLY141M, GLY90G, GLY90M, GLY97G, GLY97M, GLY98G, GLY98M, HIS100G, HIS100M, HIS133G, HIS133M, HIS66M, HIS89G, HIS89M, ILE69G, LEU116G, LEU116M, LEU135G, LEU135M, LYS140G, LYS140M, LYS68G, LYS68M, MET138G, MET138M, PHE229G, PHE229M, PRO130G, PRO130M, PRO221G, PRO221M, SER123G, SER123M, SER127G, SER127M, SER227G, SER227M, SER233G, SER233M, SER67G, SER67M, SER94G, SER94M, THR126G, THR126M, THR129G, THR129M, THR139G, THR139M, TRP137G, TRP137M, TYR149G, TYR149M, TYR228G, TYR228M, TYR47G, TYR47M, TYR91G, TYR91M, TYR95G, TYR95M, VAL117G, VAL117M, VAL128G, VAL128M, VAL237G, VAL237M
• H-I: ALA213H, ALA217H, ALA303I, ARG212H, ARG230H, ARG231H, ARG294I, ASN226H, ASN232H, ASP215H, ASP234H, GLN2I, GLU211H, GLU219H, GLU238H, GLU299I, GLY266I, GLY297I, HIS298I, ILE225H, ILE268I, ILE301I, LEU218H, LEU223H, LEU3I, PHE229H, PHE242H, PHE296I, PHE300I, PHE304I, PHE4H, PRO235H, PRO273H, PRO302I, SER227H, SER233H, TYR222H, TYR228H, TYR293I, TYR295I, VAL214H, VAL216H
• H-M: ALA106H, ALA106M, ALA303H, ALA303M, ARG174M, ASN104H, ASN104M, ASP101H, ASP101M, ASP48H, ASP48M, ASP96H, ASP96M, GLN305H, GLN305M, GLN313H, GLN313M, GLN78M, GLU299H, GLU299M, GLU307H, GLU307M, GLY109H, GLY109M, GLY53H, GLY53M, GLY97H, GLY97M, GLY98H, GLY98M, HIS100H, HIS100M, HIS108H, HIS108M, HIS82M, ILE301H, ILE301M, ILE99H, ILE99M, LEU107H, LEU107M, LEU309H, LEU309M, LEU312H, LEU312M, LEU317H, LEU317M, LEU318H, LEU318M, LYS308H, LYS308M, LYS314H, LYS314M, LYS52H, LYS52M, PHE296H, PHE296M, PHE300H, PHE300M, PHE304H, PHE304M, PHE311H, PHE311M, PRO302H, PRO302M, PRO50H, PRO50M, SER310H, SER310M, SER94H, SER94M, THR306H, THR306M, TRP105H, TRP105M, TYR110H, TYR110M, TYR295H, TYR295M, TYR47H, TYR47M, TYR49H, TYR49M, TYR95H, TYR95M, VAL103H, VAL103M, VAL51H, VAL51M, VAL54H, VAL54M
• H-N: ALA134H, ALA134N, ALA93H, ALA93N, ARG118H, ARG118N, ARG230H, ARG230N, ARG231H, ARG231N, ARG58H, ARG58N, ASN226H, ASN232H, ASN232N, ASN92H, ASN92N, ASP125H, ASP125N, ASP234H, ASP234N, ASP96H, ASP96N, GLN120H, GLN120N, GLN220H, GLN220N, GLU124H, GLU124N, GLU224H, GLU224N, GLU70H, GLU70N, GLY119H, GLY119N, GLY121H, GLY121N, GLY122H, GLY122N, GLY131H, GLY131N, GLY132H, GLY132N, GLY136H, GLY136N, GLY141H, GLY141N, GLY65H, GLY65N, GLY90N, GLY97H, GLY97N, GLY98H, GLY98N, HIS100H, HIS100N, HIS133H, HIS133N, HIS66H, HIS66N, HIS89N, ILE69H, ILE69N, LEU116H, LEU116N, LEU135H, LEU135N, LYS140H, LYS140N, LYS68H, LYS68N, MET138H, MET138N, PHE229H, PHE229N, PRO130H, PRO130N, PRO221H, PRO221N, SER123H, SER123N, SER127H, SER127N, SER227H, SER227N, SER233H, SER233N, SER67H, SER67N, SER94H, SER94N, THR126H, THR126N, THR129H, THR129N, THR139H, THR139N, TRP137H, TRP137N, TYR149H, TYR149N, TYR228H, TYR228N, TYR47H, TYR47N, TYR91H, TYR91N, TYR95H, TYR95N, VAL117H, VAL117N, VAL128H, VAL128N, VAL237H, VAL237N
• I-L: ALA134I, ALA134L, ALA93I, ALA93L, ARG118I, ARG118L, ARG230I, ARG230L, ARG231I, ARG231L, ARG58I, ARG58L, ASN226I, ASN226L, ASN232I, ASN232L, ASN92I, ASN92L, ASP125I, ASP125L, ASP234I, ASP234L, ASP96I, ASP96L, GLN120I, GLN120L, GLN220I, GLN220L, GLU124I, GLU124L, GLU224I, GLU224L, GLU70I, GLU70L, GLY119I, GLY119L, GLY121I, GLY121L, GLY122I, GLY122L, GLY131I, GLY131L, GLY132I, GLY132L, GLY136I, GLY136L, GLY141I, GLY141L, GLY65I, GLY65L, GLY90I, GLY90L, GLY97I, GLY97L, GLY98I, GLY98L, HIS100I, HIS100L, HIS133I, HIS133L, HIS66I, HIS66L, HIS89I, HIS89L, ILE69L, ILE99L, LEU116I, LEU116L, LEU135I, LEU135L, LYS140I, LYS140L, LYS68I, LYS68L, MET138I, MET138L, PHE229I, PHE229L, PRO130I, PRO130L, PRO221I, PRO221L, SER123I, SER123L, SER127I, SER127L, SER227I, SER227L, SER233I, SER233L, SER67I, SER67L, SER94I, SER94L, THR126I, THR126L, THR129I, THR129L, THR139I, THR139L, TRP137I, TRP137L, TYR149I, TYR149L, TYR206I, TYR228I, TYR228L, TYR47I, TYR91I, TYR91L, TYR95I, TYR95L, VAL117I, VAL117L, VAL128I, VAL128L, VAL237I, VAL237L
• I-N: ALA106I, ALA106N, ALA303I, ALA303N, ARG174I, ASN104I, ASN104N, ASP101I, ASP101N, ASP48I, ASP48N, ASP96I, ASP96N, GLN305I, GLN305N, GLN313I, GLN313N, GLN78I, GLN78N, GLU299I, GLU299N, GLU307I, GLU307N, GLY109I, GLY109N, GLY53I, GLY53N, GLY97I, GLY97N, GLY98I, GLY98N, HIS100I, HIS100N, HIS108I, HIS108N, ILE301I, ILE301N, ILE99I, ILE99N, LEU107I, LEU107N, LEU309I, LEU309N, LEU312I, LEU312N, LEU317I, LEU317N, LEU318I, LEU318N, LYS308I, LYS308N, LYS314I, LYS314N, LYS52I, LYS52N, PHE296I, PHE296N, PHE300I, PHE300N, PHE304I, PHE304N, PHE311I, PHE311N, PRO302I, PRO302N, PRO50I, PRO50N, PRO76N, PRO83I, SER310I, SER310N, SER94I, SER94N, THR306I, THR306N, TRP105I, TRP105N, TYR110I, TYR110N, TYR295I, TYR295N, TYR47I, TYR47N, TYR49I, TYR49N, TYR95I, TYR95N, VAL103I, VAL103N, VAL51I, VAL51N, VAL54I, VAL54N
• L-M: ALA213M, ALA217M, ALA303L, ARG212M, ARG230M, ARG231M, ARG294L, ASN226M, ASN232M, ASP215M, ASP234M, GLN2L, GLU211M, GLU219M, GLU238M, GLU299L, GLY266L, GLY297L, HIS298L, ILE225M, ILE268L, ILE301L, LEU218M, LEU223M, LEU3L, PHE210M, PHE229M, PHE242M, PHE296L, PHE300L, PHE304L, PHE4L, PHE4M, PRO235M, PRO273M, PRO302L, SER227M, SER233M, THR306L, TYR222M, TYR228M, TYR293L, TYR295L, VAL214M, VAL216M
• L-N: ALA213L, ALA217L, ALA303N, ARG212L, ARG230L, ARG231L, ARG294N, ASN226L, ASN232L, ASP215L, ASP234L, GLN2N, GLU211L, GLU219L, GLU238L, GLU299N, GLY266N, GLY297N, HIS298N, ILE225L, ILE268N, ILE301N, LEU218L, LEU223L, LEU3N, MET1N, PHE229L, PHE242L, PHE296N, PHE300N, PHE304N, PHE4L, PHE4N, PRO235L, PRO273L, PRO302N, SER227L, SER233L, THR306N, TYR222L, TYR228L, TYR293N, TYR295N, VAL214L, VAL216L
• M-N: ALA213N, ALA217N, ALA241N, ALA303M, ARG212N, ARG230N, ARG231N, ARG294M, ASN226N, ASN232N, ASP215N, ASP234N, GLN2M, GLN305M, GLU211N, GLU219N, GLU238N, GLU299M, GLY266M, GLY297M, HIS298M, ILE225N, ILE268M, ILE301M, LEU218N, LEU223N, LEU3M, MET1M, PHE229N, PHE242N, PHE296M, PHE300M, PHE304M, PHE4N, PRO235N, PRO273N, PRO302M, SER227N, SER233N, THR306M, TYR222N, TYR228N, TYR293M, TYR295M, VAL214N, VAL216N