3FVR

crystal structure of acetyl xylan esterase from bacillus pumilus, monoclinic crystal form i

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 47
  • Norm. En. per Res.: -4.6374
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-10.5377	-69.945	-117.232	-197.7147	49	1	1	4192	5	9	9
A-C	-23.4886	-71.3435	-110.095	-204.9271	49	2	1	3876	5	9	10
A-E	-21.5903	0.0	-197.53	-219.1203	97	4	3	8577	0	22	28
A-F	-129.6617	3.9063	-329.398	-455.1533	116	25	0	11204	0	27	32
B-C	-22.6304	-70.8358	-110.755	-204.2212	46	5	1	3935	4	9	9
B-D	-136.2776	5.0554	-336.039	-467.2612	118	27	0	11321	0	28	32
B-F	-27.3426	2.2592	-206.229	-231.3124	97	11	3	8976	0	22	28
C-D	-27.7279	0.0	-200.71	-228.4379	94	6	3	8728	0	22	28
C-E	-123.8788	5.3099	-311.546	-430.1149	112	20	0	11075	0	26	32
D-E	-14.972	-74.9296	-128.057	-217.9586	47	4	1	4446	5	9	10
D-F	-19.0851	-72.3493	-105.115	-196.5495	45	1	1	3681	5	9	8
E-F	-17.0802	-67.6128	-110.152	-194.845	46	2	1	3919	5	9	8
G-H	-19.6289	-76.6453	-103.819	-200.0933	44	2	1	3717	4	9	8
G-I	-7.0443	-73.7854	-99.3643	-180.1941	45	2	1	3793	5	9	8
G-L	-23.092	0.0	-192.796	-215.888	95	4	3	8537	0	20	28
G-M	-128.652	4.0244	-333.335	-457.9626	115	20	0	11179	0	27	32
H-I	-11.0563	-76.5332	-108.208	-195.7975	45	1	1	3715	5	9	8
H-L	-130.9915	5.8278	-342.015	-467.1787	117	26	0	11314	0	27	32
H-N	-26.1543	0.0	-204.787	-230.9413	96	6	3	8770	0	22	28
I-M	-26.7582	0.0	-202.964	-229.7222	96	15	3	9096	0	21	28
I-N	-131.7262	4.2283	-346.03	-473.5279	118	22	0	11394	0	27	32
L-M	-25.2197	-68.5428	-107.241	-201.0035	46	1	1	3711	5	9	8
L-N	-20.1722	-66.7123	-109.138	-196.0225	47	3	1	3768	5	9	8
M-N	-18.0162	-68.8214	-115.167	-202.0046	48	3	1	4129	5	9	8

Interface residues

• A-B: ALA213A, ALA217A, ALA241A, ALA303B, ARG212A, ARG230A, ARG231A, ARG294B, ASN226A, ASN232A, ASP215A, ASP234A, GLN220A, GLN2B, GLN305B, GLU211A, GLU219A, GLU238A, GLU299B, GLY266B, GLY297B, HIS298B, ILE225A, ILE268B, ILE301B, LEU218A, LEU223A, LEU3B, LYS270B, MET1B, PHE229A, PHE242A, PHE296B, PHE300B, PHE304B, PHE4A, PHE4B, PRO235A, PRO273A, PRO302B, SER227A, SER233A, THR306B, TYR222A, TYR228A, TYR293B, TYR295B, VAL214A, VAL216A
• A-C: ALA213C, ALA217C, ALA303A, ARG212C, ARG230C, ARG231C, ARG294A, ASN226C, ASN232C, ASP215C, ASP234C, GLN220C, GLN2A, GLN305A, GLU211C, GLU219C, GLU238C, GLU299A, GLY266A, GLY297A, HIS298A, ILE225C, ILE268A, ILE301A, LEU218C, LEU223C, LEU267A, LEU3A, LYS270A, MET1A, PHE229C, PHE242C, PHE296A, PHE300A, PHE304A, PHE4A, PHE4C, PRO235C, PRO273C, PRO302A, SER227C, SER233C, THR306A, TYR222C, TYR228C, TYR293A, TYR295A, VAL214C, VAL216C
• A-E: ALA106A, ALA106E, ALA303A, ALA303E, ARG174A, ARG174E, ASN104A, ASN104E, ASP101A, ASP101E, ASP48A, ASP48E, ASP96A, ASP96E, GLN305A, GLN305E, GLN313A, GLN313E, GLN78A, GLN78E, GLU299A, GLU299E, GLU307A, GLU307E, GLY109A, GLY109E, GLY53A, GLY53E, GLY97A, GLY97E, GLY98A, GLY98E, HIS100A, HIS100E, HIS108A, HIS108E, HIS82E, ILE301A, ILE301E, ILE99A, ILE99E, LEU107A, LEU107E, LEU309A, LEU309E, LEU312A, LEU312E, LEU317A, LEU317E, LEU318A, LEU318E, LYS308A, LYS308E, LYS314A, LYS314E, LYS52A, LYS52E, PHE296A, PHE296E, PHE300A, PHE300E, PHE304A, PHE304E, PHE311A, PHE311E, PRO302A, PRO302E, PRO50A, PRO50E, PRO76A, PRO76E, PRO83A, PRO83E, SER310A, SER310E, SER94A, SER94E, THR306A, THR306E, TRP105A, TRP105E, TYR110A, TYR110E, TYR295A, TYR295E, TYR47A, TYR47E, TYR49A, TYR49E, TYR95A, TYR95E, VAL103A, VAL103E, VAL51A, VAL51E, VAL54A, VAL54E
• A-F: ALA134A, ALA134F, ALA93A, ALA93F, ARG118A, ARG118F, ARG230A, ARG230F, ARG231A, ARG231F, ARG58A, ARG58F, ASN226A, ASN226F, ASN232A, ASN232F, ASN92A, ASN92F, ASP125A, ASP125F, ASP234A, ASP234F, ASP96A, ASP96F, GLN120A, GLN120F, GLN220A, GLN220F, GLU124A, GLU124F, GLU224A, GLU224F, GLU70A, GLU70F, GLY119A, GLY119F, GLY121A, GLY121F, GLY122A, GLY122F, GLY131A, GLY131F, GLY132A, GLY132F, GLY136A, GLY136F, GLY141A, GLY141F, GLY65F, GLY90A, GLY90F, GLY97A, GLY97F, GLY98A, GLY98F, HIS100A, HIS100F, HIS133A, HIS133F, HIS66A, HIS66F, HIS89A, HIS89F, ILE69A, LEU116A, LEU116F, LEU135A, LEU135F, LYS140A, LYS140F, LYS68A, LYS68F, MET138A, MET138F, PHE229A, PHE229F, PRO130A, PRO130F, PRO221A, PRO221F, SER123A, SER123F, SER127A, SER127F, SER227A, SER227F, SER233A, SER233F, SER67A, SER67F, SER94A, SER94F, THR126A, THR126F, THR129A, THR129F, THR139A, THR139F, TRP137A, TRP137F, TYR149A, TYR149F, TYR228A, TYR228F, TYR47A, TYR47F, TYR91A, TYR91F, TYR95A, TYR95F, VAL117A, VAL117F, VAL128A, VAL128F, VAL237A, VAL237F
• B-C: ALA213B, ALA217B, ALA303C, ARG212B, ARG230B, ARG231B, ARG294C, ASN226B, ASN232B, ASP215B, ASP234B, GLN2C, GLN305C, GLU211B, GLU219B, GLU238B, GLU299C, GLY266C, GLY297C, HIS298C, ILE225B, ILE268C, ILE301C, LEU218B, LEU223B, LEU3C, MET1C, PHE229B, PHE242B, PHE296C, PHE300C, PHE304C, PHE4B, PHE4C, PRO235B, PRO273B, PRO302C, SER227B, SER233B, THR306C, TYR222B, TYR228B, TYR293C, TYR295C, VAL214B, VAL216B
• B-D: ALA134B, ALA134D, ALA93B, ALA93D, ARG118B, ARG118D, ARG230B, ARG230D, ARG231B, ARG231D, ARG58B, ARG58D, ASN226B, ASN226D, ASN232B, ASN232D, ASN92B, ASN92D, ASP125B, ASP125D, ASP234B, ASP234D, ASP96B, ASP96D, GLN120B, GLN120D, GLN220B, GLN220D, GLU124B, GLU124D, GLU224B, GLU224D, GLU70B, GLU70D, GLY119B, GLY119D, GLY121B, GLY121D, GLY122B, GLY122D, GLY131B, GLY131D, GLY132B, GLY132D, GLY136B, GLY136D, GLY141B, GLY141D, GLY65B, GLY65D, GLY90B, GLY90D, GLY97B, GLY97D, GLY98B, GLY98D, HIS100B, HIS100D, HIS133B, HIS133D, HIS66B, HIS66D, HIS89B, HIS89D, ILE69B, ILE69D, LEU116B, LEU116D, LEU135B, LEU135D, LYS140B, LYS140D, LYS68B, LYS68D, MET138B, MET138D, PHE229B, PHE229D, PRO130B, PRO130D, PRO221B, PRO221D, SER123B, SER123D, SER127B, SER127D, SER227B, SER227D, SER233B, SER233D, SER67B, SER67D, SER94B, SER94D, THR126B, THR126D, THR129B, THR129D, THR139B, THR139D, TRP137B, TRP137D, TYR149B, TYR149D, TYR228B, TYR228D, TYR47B, TYR47D, TYR91B, TYR91D, TYR95B, TYR95D, VAL117B, VAL117D, VAL128B, VAL128D, VAL237B, VAL237D
• B-F: ALA106B, ALA106F, ALA303B, ALA303F, ARG174F, ASN104B, ASN104F, ASP101B, ASP101F, ASP48B, ASP48F, ASP96B, ASP96F, GLN305B, GLN305F, GLN313B, GLN313F, GLN78B, GLN78F, GLU299B, GLU299F, GLU307B, GLU307F, GLY109B, GLY109F, GLY53B, GLY53F, GLY97B, GLY97F, GLY98B, GLY98F, HIS100B, HIS100F, HIS108B, HIS108F, HIS82F, ILE301B, ILE301F, ILE99B, ILE99F, LEU107B, LEU107F, LEU309B, LEU309F, LEU312B, LEU312F, LEU316F, LEU317B, LEU317F, LEU318B, LEU318F, LYS308B, LYS308F, LYS314B, LYS314F, LYS52B, LYS52F, PHE296B, PHE296F, PHE300B, PHE300F, PHE304B, PHE304F, PHE311B, PHE311F, PRO302B, PRO302F, PRO50B, PRO50F, PRO76B, PRO76F, PRO83B, PRO83F, SER310B, SER310F, SER94B, SER94F, THR306B, THR306F, TRP105B, TRP105F, TYR110B, TYR110F, TYR295B, TYR295F, TYR47B, TYR47F, TYR49B, TYR49F, TYR95B, TYR95F, VAL103B, VAL103F, VAL51B, VAL51F, VAL54B, VAL54F
• C-D: ALA106C, ALA106D, ALA303C, ALA303D, ARG174C, ASN104C, ASN104D, ASP101C, ASP101D, ASP48C, ASP48D, ASP96C, ASP96D, GLN305C, GLN305D, GLN313C, GLN313D, GLN78C, GLN78D, GLU299C, GLU299D, GLU307C, GLU307D, GLY109C, GLY109D, GLY53C, GLY53D, GLY97C, GLY97D, GLY98C, GLY98D, HIS100C, HIS100D, HIS108C, HIS108D, HIS82C, ILE301C, ILE301D, ILE99C, ILE99D, LEU107C, LEU107D, LEU309C, LEU309D, LEU312C, LEU312D, LEU317C, LEU317D, LEU318C, LEU318D, LYS308C, LYS308D, LYS314C, LYS314D, LYS52C, LYS52D, PHE296C, PHE296D, PHE300C, PHE300D, PHE304C, PHE304D, PHE311C, PHE311D, PRO302C, PRO302D, PRO50C, PRO50D, PRO83C, PRO83D, SER310C, SER310D, SER94C, SER94D, THR306C, THR306D, TRP105C, TRP105D, TYR110C, TYR110D, TYR295C, TYR295D, TYR47C, TYR47D, TYR49C, TYR49D, TYR95C, TYR95D, VAL103C, VAL103D, VAL51C, VAL51D, VAL54C, VAL54D
• C-E: ALA134C, ALA134E, ALA93C, ALA93E, ARG118C, ARG118E, ARG230C, ARG230E, ARG231C, ARG231E, ARG58C, ARG58E, ASN226C, ASN226E, ASN232C, ASN232E, ASN92C, ASN92E, ASP125C, ASP125E, ASP234C, ASP234E, ASP96C, ASP96E, GLN120C, GLN120E, GLN220C, GLN220E, GLU124C, GLU124E, GLU224C, GLU224E, GLU70C, GLU70E, GLY119C, GLY119E, GLY121C, GLY121E, GLY122C, GLY122E, GLY131C, GLY131E, GLY132C, GLY132E, GLY136C, GLY136E, GLY141C, GLY141E, GLY65E, GLY90C, GLY90E, GLY97C, GLY97E, GLY98C, GLY98E, HIS100C, HIS100E, HIS133C, HIS133E, HIS66C, LEU116C, LEU116E, LEU135C, LEU135E, LYS140C, LYS140E, LYS68C, LYS68E, MET138C, MET138E, PHE229C, PHE229E, PRO130C, PRO130E, PRO221C, PRO221E, SER123C, SER123E, SER127C, SER127E, SER227C, SER227E, SER233C, SER233E, SER67C, SER67E, SER94C, SER94E, THR126C, THR126E, THR129C, THR129E, THR139C, THR139E, TRP137C, TRP137E, TYR149C, TYR149E, TYR228C, TYR228E, TYR47C, TYR47E, TYR91C, TYR91E, TYR95C, TYR95E, VAL117C, VAL117E, VAL128C, VAL128E, VAL237C, VAL237E
• D-E: ALA213E, ALA217E, ALA303D, ARG212E, ARG230E, ARG231E, ARG294D, ASN226E, ASN232E, ASP215E, ASP234E, GLN220E, GLN2D, GLU211E, GLU219E, GLU238E, GLU299D, GLY266D, GLY297D, HIS298D, ILE225E, ILE268D, ILE301D, LEU218E, LEU223E, LEU3D, LYS270D, MET1D, PHE229E, PHE242E, PHE296D, PHE300D, PHE304D, PHE4D, PHE4E, PRO235E, PRO273E, PRO302D, SER227E, SER233E, THR306D, TYR222E, TYR228E, TYR293D, TYR295D, VAL214E, VAL216E
• D-F: ALA213D, ALA217D, ALA303F, ARG212D, ARG230D, ARG231D, ARG294F, ASN226D, ASN232D, ASP215D, ASP234D, GLN2F, GLU211D, GLU219D, GLU238D, GLU299F, GLY266F, GLY297F, HIS298F, ILE225D, ILE268F, ILE301F, LEU218D, LEU223D, LEU3F, LYS270F, PHE210D, PHE229D, PHE242D, PHE296F, PHE300F, PHE304F, PHE4D, PHE4F, PRO235D, PRO273D, PRO302F, SER227D, SER233D, TYR222D, TYR228D, TYR293F, TYR295F, VAL214D, VAL216D
• E-F: ALA213F, ALA217F, ALA303E, ARG212F, ARG230F, ARG231F, ARG294E, ASN226F, ASN232F, ASP215F, ASP234F, GLN220F, GLN2E, GLU211F, GLU219F, GLU238F, GLU299E, GLY266E, GLY297E, HIS298E, ILE225F, ILE268E, ILE301E, LEU218F, LEU223F, LEU3E, MET1E, PHE229F, PHE242F, PHE296E, PHE300E, PHE304E, PHE4E, PHE4F, PRO235F, PRO273F, PRO302E, SER227F, SER233F, THR306E, TYR222F, TYR228F, TYR293E, TYR295E, VAL214F, VAL216F
• G-H: ALA213H, ALA217H, ALA303G, ARG212H, ARG230H, ARG231H, ARG294G, ASN226H, ASN232H, ASP215H, ASP234H, GLN2G, GLU211H, GLU219H, GLU238H, GLU299G, GLY266G, GLY297G, HIS298G, ILE225H, ILE268G, ILE301G, LEU218H, LEU223H, LEU3G, PHE229H, PHE242H, PHE296G, PHE300G, PHE304G, PHE4G, PHE4H, PRO235H, PRO273H, PRO302G, SER227H, SER233H, THR306G, TYR222H, TYR228H, TYR293G, TYR295G, VAL214H, VAL216H
• G-I: ALA213G, ALA217G, ALA303I, ARG212G, ARG230G, ARG231G, ARG294I, ASN226G, ASN232G, ASP215G, ASP234G, GLN2I, GLU211G, GLU219G, GLU238G, GLU299I, GLY266I, GLY297I, HIS298I, ILE225G, ILE268I, ILE301I, LEU218G, LEU223G, LEU3I, LYS270G, LYS270I, MET1I, PHE229G, PHE242G, PHE296I, PHE300I, PHE304I, PHE4G, PHE4I, PRO235G, PRO302I, SER227G, SER233G, THR306I, TYR228G, TYR293I, TYR295I, VAL214G, VAL216G
• G-L: ALA106G, ALA106L, ALA303G, ALA303L, ARG174L, ASN104G, ASN104L, ASP101G, ASP101L, ASP48G, ASP48L, ASP96G, ASP96L, GLN305G, GLN305L, GLN313G, GLN313L, GLN78G, GLN78L, GLU299G, GLU299L, GLU307G, GLU307L, GLY109G, GLY109L, GLY53G, GLY53L, GLY97G, GLY97L, GLY98G, GLY98L, HIS100G, HIS100L, HIS108G, HIS108L, ILE301G, ILE301L, ILE99G, ILE99L, LEU107G, LEU107L, LEU309G, LEU309L, LEU312G, LEU312L, LEU317G, LEU317L, LEU318G, LEU318L, LYS308G, LYS308L, LYS314G, LYS314L, LYS52G, LYS52L, PHE296G, PHE296L, PHE300G, PHE300L, PHE304G, PHE304L, PHE311G, PHE311L, PRO302G, PRO302L, PRO50G, PRO50L, PRO76G, PRO76L, PRO83G, PRO83L, SER310G, SER310L, SER94G, SER94L, THR306G, THR306L, TRP105G, TRP105L, TYR110G, TYR110L, TYR295G, TYR295L, TYR47G, TYR47L, TYR49G, TYR49L, TYR95G, TYR95L, VAL103G, VAL103L, VAL51G, VAL51L, VAL54G, VAL54L
• G-M: ALA134G, ALA134M, ALA93G, ALA93M, ARG118G, ARG118M, ARG230G, ARG230M, ARG231G, ARG231M, ARG58G, ARG58M, ASN226G, ASN226M, ASN232G, ASN232M, ASN92G, ASN92M, ASP125G, ASP125M, ASP234G, ASP234M, ASP96G, ASP96M, GLN120G, GLN120M, GLN220G, GLN220M, GLU124G, GLU124M, GLU224G, GLU224M, GLU70G, GLU70M, GLY119G, GLY119M, GLY121G, GLY121M, GLY122G, GLY122M, GLY131G, GLY131M, GLY132G, GLY132M, GLY136G, GLY136M, GLY141G, GLY141M, GLY65G, GLY90G, GLY90M, GLY97G, GLY97M, GLY98G, GLY98M, HIS100G, HIS100M, HIS133G, HIS133M, HIS66G, HIS66M, HIS89G, HIS89M, ILE69G, LEU116G, LEU116M, LEU135G, LEU135M, LYS140G, LYS140M, LYS68G, LYS68M, MET138G, MET138M, PHE229G, PHE229M, PRO130G, PRO130M, PRO221G, PRO221M, SER123G, SER123M, SER127G, SER127M, SER227G, SER227M, SER233G, SER233M, SER67G, SER67M, SER94G, SER94M, THR126G, THR126M, THR129G, THR129M, THR139G, THR139M, TRP137G, TRP137M, TYR149G, TYR149M, TYR228G, TYR228M, TYR47G, TYR47M, TYR91G, TYR91M, TYR95G, TYR95M, VAL117G, VAL117M, VAL128G, VAL128M, VAL237M
• H-I: ALA213I, ALA217I, ALA303H, ARG212I, ARG230I, ARG231I, ARG294H, ASN226I, ASN232I, ASP215I, ASP234I, GLN2H, GLU211I, GLU219I, GLU238I, GLU299H, GLY266H, GLY297H, HIS298H, ILE225I, ILE268H, ILE301H, LEU218I, LEU223I, LEU3H, LYS270H, PHE210I, PHE229I, PHE242I, PHE296H, PHE300H, PHE304H, PHE4H, PHE4I, PRO235I, PRO273I, PRO302H, SER227I, SER233I, TYR222I, TYR228I, TYR293H, TYR295H, VAL214I, VAL216I
• H-L: ALA134H, ALA134L, ALA93H, ALA93L, ARG118H, ARG118L, ARG230H, ARG230L, ARG231H, ARG231L, ARG58H, ARG58L, ASN226H, ASN226L, ASN232H, ASN232L, ASN92H, ASN92L, ASP125H, ASP125L, ASP234H, ASP234L, ASP96H, ASP96L, GLN120H, GLN120L, GLN220H, GLN220L, GLU124H, GLU124L, GLU224H, GLU224L, GLU70H, GLU70L, GLY119H, GLY119L, GLY121H, GLY121L, GLY122H, GLY122L, GLY131H, GLY131L, GLY132H, GLY132L, GLY136H, GLY136L, GLY141H, GLY141L, GLY65H, GLY90H, GLY90L, GLY97H, GLY97L, GLY98H, GLY98L, HIS100H, HIS100L, HIS133H, HIS133L, HIS66H, HIS66L, HIS89H, HIS89L, ILE69H, ILE69L, LEU116H, LEU116L, LEU135H, LEU135L, LYS140H, LYS140L, LYS68H, LYS68L, MET138H, MET138L, PHE229H, PHE229L, PRO130H, PRO130L, PRO221H, PRO221L, SER123H, SER123L, SER127H, SER127L, SER227H, SER227L, SER233H, SER233L, SER67H, SER67L, SER94H, SER94L, THR126H, THR126L, THR129H, THR129L, THR139H, THR139L, TRP137H, TRP137L, TYR149H, TYR149L, TYR228H, TYR228L, TYR47H, TYR47L, TYR91H, TYR91L, TYR95H, TYR95L, VAL117H, VAL117L, VAL128H, VAL128L, VAL237H, VAL237L
• H-N: ALA106H, ALA106N, ALA303H, ALA303N, ARG174H, ASN104H, ASN104N, ASP101H, ASP101N, ASP48H, ASP48N, ASP96H, ASP96N, GLN305H, GLN305N, GLN313H, GLN313N, GLN78H, GLN78N, GLU299H, GLU299N, GLU307H, GLU307N, GLY109H, GLY109N, GLY53H, GLY53N, GLY97H, GLY97N, GLY98H, GLY98N, HIS100H, HIS100N, HIS108H, HIS108N, HIS82H, ILE301H, ILE301N, ILE99H, ILE99N, LEU107H, LEU107N, LEU309H, LEU309N, LEU312H, LEU312N, LEU317H, LEU317N, LEU318H, LEU318N, LYS308H, LYS308N, LYS314H, LYS314N, LYS52H, LYS52N, PHE296H, PHE296N, PHE300H, PHE300N, PHE304H, PHE304N, PHE311H, PHE311N, PRO302H, PRO302N, PRO50H, PRO50N, PRO76H, PRO76N, PRO83H, PRO83N, SER310H, SER310N, SER94H, SER94N, THR306H, THR306N, TRP105H, TRP105N, TYR110H, TYR110N, TYR295H, TYR295N, TYR47H, TYR47N, TYR49H, TYR49N, TYR95H, TYR95N, VAL103H, VAL103N, VAL51H, VAL51N, VAL54H, VAL54N
• I-M: ALA106I, ALA106M, ALA303I, ALA303M, ARG174I, ASN104I, ASN104M, ASP101I, ASP101M, ASP48I, ASP48M, ASP96I, ASP96M, GLN305I, GLN305M, GLN313I, GLN313M, GLN78I, GLU299I, GLU299M, GLU307I, GLU307M, GLY109I, GLY109M, GLY53I, GLY53M, GLY97I, GLY97M, GLY98I, GLY98M, HIS100I, HIS100M, HIS108I, HIS108M, HIS82I, ILE301I, ILE301M, ILE99I, ILE99M, LEU107I, LEU107M, LEU309I, LEU309M, LEU312I, LEU312M, LEU316I, LEU317I, LEU317M, LEU318I, LEU318M, LYS308I, LYS308M, LYS314I, LYS314M, LYS52I, LYS52M, PHE296I, PHE296M, PHE300I, PHE300M, PHE304I, PHE304M, PHE311I, PHE311M, PRO302I, PRO302M, PRO50I, PRO50M, PRO76I, PRO83I, PRO83M, SER310I, SER310M, SER319I, SER94I, SER94M, THR306I, THR306M, TRP105I, TRP105M, TYR110I, TYR110M, TYR295I, TYR295M, TYR47I, TYR47M, TYR49I, TYR49M, TYR95I, TYR95M, VAL103I, VAL103M, VAL51I, VAL51M, VAL54I, VAL54M
• I-N: ALA134I, ALA134N, ALA93I, ALA93N, ARG118I, ARG118N, ARG230I, ARG230N, ARG231I, ARG231N, ARG58I, ARG58N, ASN226I, ASN226N, ASN232I, ASN232N, ASN92I, ASN92N, ASP125I, ASP125N, ASP234I, ASP234N, ASP96I, ASP96N, GLN120I, GLN120N, GLN220I, GLN220N, GLU124I, GLU124N, GLU224I, GLU224N, GLU70I, GLU70N, GLY119I, GLY119N, GLY121I, GLY121N, GLY122I, GLY122N, GLY131I, GLY131N, GLY132I, GLY132N, GLY136I, GLY136N, GLY141I, GLY141N, GLY65I, GLY65N, GLY90I, GLY90N, GLY97I, GLY97N, GLY98I, GLY98N, HIS100I, HIS100N, HIS133I, HIS133N, HIS66I, HIS66N, HIS89I, HIS89N, ILE69I, ILE69N, LEU116I, LEU116N, LEU135I, LEU135N, LYS140I, LYS140N, LYS68I, LYS68N, MET138I, MET138N, PHE229I, PHE229N, PRO130I, PRO130N, PRO221I, PRO221N, SER123I, SER123N, SER127I, SER127N, SER227I, SER227N, SER233I, SER233N, SER67I, SER67N, SER94I, SER94N, THR126I, THR126N, THR129I, THR129N, THR139I, THR139N, TRP137I, TRP137N, TYR149I, TYR149N, TYR228I, TYR228N, TYR47I, TYR47N, TYR91I, TYR91N, TYR95I, TYR95N, VAL117I, VAL117N, VAL128I, VAL128N, VAL237I, VAL237N
• L-M: ALA213M, ALA217M, ALA303L, ARG212M, ARG230M, ARG231M, ARG294L, ASN226M, ASN232M, ASP215M, ASP234M, GLN2L, GLN305L, GLU211M, GLU219M, GLU238M, GLU299L, GLY266L, GLY297L, HIS298L, ILE225M, ILE268L, ILE301L, LEU218M, LEU223M, LEU3L, LYS270L, PHE229M, PHE242M, PHE296L, PHE300L, PHE304L, PHE4L, PHE4M, PRO235M, PRO273M, PRO302L, SER227M, SER233M, THR306L, TYR222M, TYR228M, TYR293L, TYR295L, VAL214M, VAL216M
• L-N: ALA213L, ALA217L, ALA241L, ALA303N, ARG212L, ARG230L, ARG231L, ARG294N, ASN226L, ASN232L, ASP215L, ASP234L, GLN2N, GLN305N, GLU211L, GLU219L, GLU238L, GLU299N, GLY266N, GLY297N, HIS298N, ILE225L, ILE268N, ILE301N, LEU218L, LEU223L, LEU267N, LEU3N, PHE229L, PHE242L, PHE296N, PHE300N, PHE304N, PHE4L, PHE4N, PRO235L, PRO273L, PRO302N, SER227L, SER233L, THR306N, TYR222L, TYR228L, TYR293N, TYR295N, VAL214L, VAL216L
• M-N: ALA213N, ALA217N, ALA241N, ALA303M, ARG212N, ARG230N, ARG231N, ARG294M, ASN226N, ASN232N, ASP215N, ASP234N, GLN220N, GLN2M, GLN305M, GLU211N, GLU219N, GLU238N, GLU299M, GLY266M, GLY297M, HIS298M, ILE225N, ILE268M, ILE301M, LEU218N, LEU223N, LEU3M, LYS270M, MET1M, PHE229N, PHE242N, PHE296M, PHE300M, PHE304M, PHE4N, PRO235N, PRO273N, PRO302M, SER227N, SER233N, THR306M, TYR222N, TYR228N, TYR293M, TYR295M, VAL214N, VAL216N