3FSL

crystal structure of tyrosine aminotransferase tripple mutant (p181q, r183g,a321k) from escherichia coli at 2.35 a resolution

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 265
  • Norm. En. per Res.: -4.2391
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-181.7514	-148.6871	-792.922	-1123.3605	265	52	22	32026	9	46	38
A-C	-3.2469	0.0	-18.4238	-21.6707	23	0	0	810	0	7	4
A-D	-17.9119	-25.7968	-80.6124	-124.3211	31	1	1	3123	1	20	17
A-F	-8.4118	8.4049	-15.7957	-15.8027	37	2	0	1061	3	17	17
B-C	-16.6661	-14.9957	-53.953	-85.6147	55	6	1	3635	1	26	27
B-D	0.0	-0.6739	-12.5983	-13.2722	18	0	0	726	0	9	4
C-D	-178.7704	-144.7346	-814.769	-1138.274	271	44	22	32130	10	47	36
D-E	-5.9583	11.5151	-22.7126	-17.1558	29	1	2	1220	4	9	9
E-F	-169.3115	-103.0799	-788.142	-1060.5334	269	41	22	31732	7	48	37

Interface residues

• A-B: ALA101B, ALA111A, ALA111B, ALA116A, ALA116B, ALA11A, ALA11B, ALA13A, ALA13B, ALA145A, ALA145B, ALA148A, ALA148B, ALA150A, ALA150B, ALA182A, ALA182B, ALA224A, ALA224B, ALA250A, ALA250B, ALA279A, ALA279B, ALA280A, ALA280B, ALA289A, ALA289B, ALA303A, ALA303B, ALA54A, ALA58A, ALA58B, ALA62A, ALA67A, ALA67B, ARG121A, ARG121B, ARG266A, ARG266B, ARG282A, ARG282B, ARG292A, ARG292B, ARG293A, ARG293B, ARG99A, ARG99B, ASN142A, ASN142B, ASN294A, ASN294B, ASN300A, ASN300B, ASN61A, ASN61B, ASP10A, ASP10B, ASP117A, ASP117B, ASP15A, ASP15B, ASP276A, ASP276B, CYS274A, CYS274B, GLN104A, GLN104B, GLN286A, GLN286B, GLN304A, GLN304B, GLN49A, GLN49B, GLN7A, GLN7B, GLU141A, GLU141B, GLU216A, GLU216B, GLU22B, GLU265A, GLU265B, GLU275A, GLU275B, GLU278A, GLU278B, GLU57A, GLU57B, GLU74A, GLU74B, GLY107A, GLY107B, GLY108A, GLY108B, GLY110A, GLY110B, GLY149A, GLY149B, GLY14A, GLY14B, GLY151A, GLY151B, GLY183A, GLY183B, GLY247A, GLY247B, GLY264A, GLY264B, GLY281A, GLY281B, GLY285A, GLY285B, GLY302A, GLY302B, GLY38A, GLY38B, GLY66A, GLY66B, HIS143A, HIS143B, HIS65A, HIS65B, ILE146A, ILE146B, ILE17A, ILE17B, ILE185A, ILE185B, ILE218A, ILE218B, ILE37A, ILE37B, ILE46A, ILE46B, ILE47A, ILE47B, LEU106A, LEU106B, LEU112A, LEU112B, LEU119A, LEU119B, LEU18A, LEU18B, LEU217A, LEU217B, LEU248A, LEU248B, LEU251A, LEU251B, LEU262A, LEU262B, LEU284A, LEU284B, LEU287A, LEU287B, LEU39A, LEU39B, LEU50A, LEU50B, LEU60B, LEU69A, LEU69B, LEU71A, LEU71B, LYS113A, LYS113B, LYS258A, LYS258B, LYS25B, LYS288A, LYS288B, LYS8A, LYS8B, MET273A, MET273B, MET5A, MET5B, MET73A, MET73B, PHE118A, PHE118B, PHE123A, PHE123B, PHE147A, PHE147B, PHE256A, PHE260A, PHE260B, PHE301A, PHE301B, PHE6A, PHE6B, PRO16A, PRO16B, PRO219A, PRO219B, PRO249A, PRO249B, PRO298A, PRO298B, PRO299A, PRO299B, PRO48A, PRO48B, PRO72A, PRO72B, SER109A, SER109B, SER126A, SER126B, SER184A, SER184B, SER255A, SER255B, SER257A, SER257B, SER261A, SER261B, SER296A, SER296B, SER297A, SER297B, SER68A, SER68B, THR105A, THR105B, THR19B, THR290A, THR290B, TRP140A, TRP140B, TYR122A, TYR122B, TYR12A, TYR12B, TYR225A, TYR225B, TYR263A, TYR263B, TYR295A, TYR295B, TYR40A, TYR40B, TYR41A, TYR41B, TYR70A, TYR70B, VAL114A, VAL114B, VAL144A, VAL144B, VAL267A, VAL267B, VAL272A, VAL272B, VAL283A, VAL283B, VAL291A, VAL291B, VAL305A, VAL53A, VAL53B, VAL9A, VAL9B
• A-C: ALA67A, ARG29C, ARG372C, ARG374C, ASN77A, ASP27C, ASP371C, GLN63A, GLN7C, GLU26C, GLU375C, GLU376C, GLY378C, GLY66A, HIS65A, LEU69A, LYS96A, PHE377C, PRO28C, PRO64A, PRO72A, SER30C, TYR70A
• A-D: ALA277A, ALA277D, ALA279A, ALA279D, ALA280A, ALA280D, ALA90D, ARG282A, ARG282D, ARG99A, ARG99D, ASP276A, ASP276D, GLN97A, GLN97D, GLN98A, GLN98D, GLU275A, GLU275D, GLU278A, GLU278D, GLY281A, GLY281D, LEU95A, LEU95D, LYS96A, LYS96D, PRO93A, PRO93D, VAL94A, VAL94D
• A-F: ALA175A, ALA207A, ALA214A, ALA242A, ALA332F, ARG215A, ARG329F, ASN171A, ASN202A, ASN42F, ASP203A, ASP206A, GLN204A, GLN335F, GLN51F, GLU210A, GLU322F, GLU324F, GLU325F, GLU336F, GLU43F, ILE209A, ILE211A, LEU174A, LEU331F, LYS178A, LYS321F, LYS339F, MET333F, PHE170A, SER245A, THR179A, THR201A, THR328F, THR394F, TRP205A, TYR238A
• B-C: ALA395B, ALA395C, ARG29B, ARG29C, ARG399B, ARG399C, ASN34B, ASN34C, ASN393B, ASN393C, ASN396B, ASN396C, ASN42B, ASN42C, ASP27B, ASP27C, ASP31B, ASP31C, ASP44B, ASP44C, GLU22B, GLU22C, GLU26B, GLU26C, GLU376B, GLU43B, GLU43C, GLY378B, GLY391B, GLY391C, GLY45B, GLY45C, ILE46B, ILE46C, ILE47B, ILE47C, LEU39B, LEU39C, LYS25B, LYS25C, LYS32B, LYS32C, MET21B, PHE24B, PHE24C, PHE377B, PHE377C, PRO28B, PRO28C, SER30B, SER30C, TYR41B, TYR41C, VAL33B, VAL33C
• B-D: ALA67D, ARG29B, ARG372B, ARG374B, ASP27B, ASP371B, GLN63D, GLN7B, GLU26B, GLU375B, GLU376B, GLY66D, HIS65D, LEU69D, LYS96D, PHE377B, PRO28B, PRO64D
• C-D: ALA101C, ALA111C, ALA111D, ALA116C, ALA116D, ALA11C, ALA11D, ALA13C, ALA13D, ALA145C, ALA145D, ALA148C, ALA148D, ALA150C, ALA150D, ALA182C, ALA182D, ALA224C, ALA224D, ALA250C, ALA250D, ALA279C, ALA279D, ALA280C, ALA280D, ALA289C, ALA289D, ALA303C, ALA303D, ALA54C, ALA54D, ALA58C, ALA58D, ALA62C, ALA62D, ALA67C, ALA67D, ARG121C, ARG121D, ARG266C, ARG266D, ARG282C, ARG282D, ARG292C, ARG292D, ARG293C, ARG293D, ARG59C, ARG59D, ARG99C, ARG99D, ASN142C, ASN142D, ASN294C, ASN294D, ASN300C, ASN300D, ASN61C, ASN61D, ASP10C, ASP10D, ASP117C, ASP117D, ASP15C, ASP15D, ASP276C, ASP276D, CYS274C, CYS274D, GLN104C, GLN104D, GLN286C, GLN286D, GLN304C, GLN304D, GLN49C, GLN49D, GLN7C, GLN7D, GLU141C, GLU141D, GLU216C, GLU216D, GLU22C, GLU265C, GLU265D, GLU275C, GLU275D, GLU278C, GLU278D, GLU57C, GLU57D, GLU74C, GLU74D, GLY107C, GLY107D, GLY108C, GLY108D, GLY110C, GLY110D, GLY149C, GLY149D, GLY14C, GLY14D, GLY151C, GLY151D, GLY183C, GLY183D, GLY247C, GLY247D, GLY264C, GLY264D, GLY281C, GLY281D, GLY285C, GLY285D, GLY302C, GLY302D, GLY38C, GLY38D, GLY66C, GLY66D, HIS143C, HIS143D, HIS65C, HIS65D, ILE146C, ILE146D, ILE17C, ILE17D, ILE185C, ILE185D, ILE218C, ILE218D, ILE37C, ILE37D, ILE46C, ILE46D, ILE47C, ILE47D, LEU106C, LEU106D, LEU112C, LEU112D, LEU119C, LEU119D, LEU18C, LEU18D, LEU217C, LEU217D, LEU248C, LEU248D, LEU251C, LEU251D, LEU262C, LEU262D, LEU284C, LEU284D, LEU287C, LEU287D, LEU39C, LEU39D, LEU50C, LEU50D, LEU60C, LEU60D, LEU69C, LEU69D, LEU71C, LEU71D, LYS113C, LYS113D, LYS258C, LYS258D, LYS25C, LYS288C, LYS288D, LYS8C, LYS8D, MET273C, MET273D, MET5C, MET5D, MET73C, MET73D, PHE118C, PHE118D, PHE123C, PHE123D, PHE147C, PHE147D, PHE260C, PHE260D, PHE301C, PHE301D, PHE6C, PHE6D, PRO16C, PRO16D, PRO219C, PRO219D, PRO249C, PRO249D, PRO298C, PRO298D, PRO299C, PRO299D, PRO48C, PRO48D, PRO72C, PRO72D, SER109C, SER109D, SER126C, SER126D, SER184C, SER184D, SER255C, SER255D, SER257C, SER257D, SER261C, SER261D, SER296C, SER296D, SER297C, SER297D, SER68C, SER68D, THR105C, THR105D, THR19C, THR19D, THR290C, THR290D, TRP140C, TRP140D, TYR122C, TYR122D, TYR12C, TYR12D, TYR225C, TYR225D, TYR263C, TYR263D, TYR295C, TYR295D, TYR40C, TYR40D, TYR41C, TYR41D, TYR70C, TYR70D, VAL100C, VAL114C, VAL114D, VAL144C, VAL144D, VAL267C, VAL267D, VAL272C, VAL272D, VAL283C, VAL283D, VAL291C, VAL291D, VAL305D, VAL53C, VAL53D, VAL9C, VAL9D
• D-E: ALA175D, ALA182D, ALA214D, ALA314E, ALA54E, ALA56E, ALA58E, ALA62E, ARG215D, ARG59E, ASN61E, ASP312E, GLN181D, GLN51E, GLN63E, GLU210D, GLU216D, GLU313E, GLU55E, ILE211D, LEU174D, LEU177D, LEU180D, LEU315E, LYS178D, LYS213D, PRO64E, SER318E, THR179D
• E-F: ALA111E, ALA111F, ALA116E, ALA116F, ALA11E, ALA11F, ALA13E, ALA13F, ALA145E, ALA145F, ALA148E, ALA148F, ALA150E, ALA150F, ALA182E, ALA182F, ALA224E, ALA224F, ALA250E, ALA250F, ALA279E, ALA279F, ALA280E, ALA280F, ALA289E, ALA289F, ALA303E, ALA303F, ALA54E, ALA54F, ALA58E, ALA58F, ALA62E, ALA62F, ALA67E, ALA67F, ARG121E, ARG121F, ARG266E, ARG266F, ARG282E, ARG282F, ARG292E, ARG292F, ARG293E, ARG293F, ARG59E, ARG59F, ARG99E, ARG99F, ASN142E, ASN142F, ASN294E, ASN294F, ASN300E, ASN300F, ASN61E, ASN61F, ASP10E, ASP10F, ASP117E, ASP117F, ASP15E, ASP15F, ASP276E, ASP276F, CYS274E, CYS274F, GLN104E, GLN104F, GLN286E, GLN286F, GLN304E, GLN304F, GLN49E, GLN49F, GLN7E, GLN7F, GLU141E, GLU141F, GLU216E, GLU216F, GLU22E, GLU22F, GLU265E, GLU265F, GLU275E, GLU275F, GLU278E, GLU278F, GLU57E, GLU57F, GLU74E, GLU74F, GLY107E, GLY107F, GLY108E, GLY108F, GLY110E, GLY110F, GLY149E, GLY149F, GLY14E, GLY14F, GLY151E, GLY151F, GLY183E, GLY183F, GLY247E, GLY247F, GLY264E, GLY264F, GLY281E, GLY281F, GLY285E, GLY285F, GLY302E, GLY302F, GLY38E, GLY38F, GLY66E, GLY66F, HIS143E, HIS143F, HIS65E, HIS65F, ILE146E, ILE146F, ILE17E, ILE17F, ILE185E, ILE218E, ILE218F, ILE37E, ILE37F, ILE46E, ILE46F, ILE47E, ILE47F, LEU106E, LEU106F, LEU112E, LEU112F, LEU119E, LEU119F, LEU18E, LEU18F, LEU217E, LEU217F, LEU248E, LEU248F, LEU251E, LEU251F, LEU262E, LEU262F, LEU284E, LEU284F, LEU287E, LEU287F, LEU39E, LEU39F, LEU50E, LEU50F, LEU60E, LEU60F, LEU69E, LEU69F, LEU71E, LEU71F, LYS113E, LYS113F, LYS258E, LYS258F, LYS288E, LYS288F, LYS8E, LYS8F, MET273E, MET273F, MET5E, MET5F, MET73E, MET73F, PHE118E, PHE118F, PHE123E, PHE123F, PHE147E, PHE147F, PHE260E, PHE260F, PHE301E, PHE301F, PHE6E, PHE6F, PRO16E, PRO16F, PRO219E, PRO219F, PRO249E, PRO249F, PRO298E, PRO298F, PRO299E, PRO299F, PRO48E, PRO48F, PRO72E, PRO72F, SER109E, SER109F, SER126E, SER126F, SER184E, SER184F, SER255E, SER255F, SER257E, SER257F, SER261E, SER261F, SER296E, SER296F, SER297E, SER297F, SER68E, SER68F, THR105E, THR105F, THR19E, THR19F, THR290E, THR290F, TRP140E, TRP140F, TYR122E, TYR122F, TYR12E, TYR12F, TYR225E, TYR225F, TYR263E, TYR263F, TYR295E, TYR295F, TYR40E, TYR40F, TYR41E, TYR41F, TYR70E, TYR70F, VAL114E, VAL114F, VAL144E, VAL144F, VAL267E, VAL267F, VAL272E, VAL272F, VAL283E, VAL283F, VAL291E, VAL291F, VAL305E, VAL305F, VAL53E, VAL53F, VAL9E, VAL9F