3FP9

crystal structure of intern domain of proteasome-associated atpase, mycobacterium tuberculosis

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 114
  • Norm. En. per Res.: -4.1677
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-87.6993	-41.9873	-297.24	-426.9266	123	14	7	11712	6	55	50
A-F	-88.1901	-36.3891	-304.78	-429.3591	121	15	7	11832	7	58	47
A-G	0.0	7.1223	-31.5425	-24.4202	20	0	5	1927	0	0	10
A-L	0.0	0.0	-0.0623	-0.0623	4	0	0	10	0	4	8
B-C	-85.111	-84.6359	-303.757	-473.5039	122	16	7	11925	7	56	47
B-K	0.0	0.0	-0.0077	-0.0077	2	0	0	1	0	4	6
B-L	0.0	6.6052	-41.9153	-35.3101	20	0	5	2166	0	0	11
C-D	-80.2002	-79.3159	-302.645	-462.1612	123	17	7	11777	7	58	49
C-J	0.0	0.0	-0.236	-0.236	4	0	0	20	0	4	8
C-K	0.0	7.562	-38.7737	-31.2117	20	2	5	2170	0	0	12
D-E	-86.8232	-44.1598	-298.008	-428.9911	120	14	7	11584	7	53	47
D-I	0.0	0.0	-0.0096	-0.0096	2	0	0	1	0	4	9
D-J	0.0	8.8101	-42.754	-33.9439	20	0	6	2241	0	0	12
E-F	-89.9477	-80.9966	-304.176	-475.1203	114	20	8	11524	7	53	47
E-H	0.0	0.0	-0.0428	-0.0428	4	0	0	5	0	4	8
E-I	0.0	9.077	-43.3218	-34.2448	20	1	6	2271	0	0	12
F-G	0.0	0.0	-0.1348	-0.1348	4	0	0	15	0	4	6
F-H	0.0	9.8476	-50.379	-40.5314	20	3	6	2386	0	0	12
G-H	-75.8685	-37.633	-303.763	-417.2645	121	21	7	11789	7	58	47
G-L	-77.3112	-45.0406	-298.209	-420.5608	119	17	7	11817	7	56	45
H-I	-103.7822	-41.3949	-303.213	-448.3902	122	18	7	11906	7	56	47
I-J	-100.9591	-90.3804	-310.429	-501.7685	126	25	7	11778	7	57	48
J-K	-79.9953	-31.7017	-299.741	-411.4379	121	15	7	11597	7	55	49
K-L	-71.0065	-40.2634	-308.521	-419.7909	118	18	7	11704	7	54	44

Interface residues

• A-B: ALA106A, ALA146A, ALA157B, ALA169A, ALA174A, ALA180A, ALA180B, ALA226A, ALA229A, ALA236B, ARG120A, ARG123A, ARG142B, ARG165A, ARG173A, ARG184A, ARG212A, ARG215A, ARG232B, ASN144B, ASP110A, ASP114A, ASP170A, ASP181A, ASP199A, ASP218A, ASP223A, ASP223B, ASP240B, GLU145A, GLU145B, GLU151B, GLU156B, GLU160B, GLU166A, GLU182A, GLU182B, GLU183A, GLU203A, GLU231B, GLU237B, GLU239B, GLU244B, GLU245B, GLY100B, GLY102B, GLY119A, GLY119B, GLY153B, GLY159B, GLY178A, GLY178B, GLY217A, GLY227A, HIS108A, HIS172A, HIS179A, HIS179B, ILE161B, ILE167A, ILE233B, LEU105A, LEU124A, LEU143A, LEU143B, LEU147A, LEU147B, LEU164A, LEU168A, LEU175A, LEU188A, LEU214A, LEU220B, LEU221B, LEU241B, LEU243B, LEU246B, LYS121A, LYS213A, LYS225A, LYS225B, LYS235B, MET122A, MET122B, PHE116A, PHE155B, PHE230B, PRO202A, PRO216A, PRO234B, PRO98B, SER118B, SER162B, SER219B, SER99B, THR112A, THR117A, THR117B, THR125A, THR140B, THR148A, THR154B, THR163A, THR163B, THR209B, THR224A, THR224B, TRP187A, TYR101B, TYR228A, VAL113A, VAL115A, VAL141B, VAL150B, VAL158B, VAL176A, VAL177A, VAL185A, VAL186A, VAL222B, VAL238B, VAL242B, VAL247B
• A-F: ALA106F, ALA146F, ALA157A, ALA169F, ALA174F, ALA180A, ALA180F, ALA226F, ALA229F, ALA236A, ARG120F, ARG123F, ARG142A, ARG165F, ARG173F, ARG184F, ARG212F, ARG215F, ARG232A, ASN144A, ASP110F, ASP114F, ASP170F, ASP181A, ASP181F, ASP218F, ASP223A, ASP223F, ASP240A, GLU145A, GLU145F, GLU151A, GLU156A, GLU160A, GLU166F, GLU182A, GLU182F, GLU183F, GLU231A, GLU237A, GLU239A, GLU244A, GLU245A, GLY100A, GLY102A, GLY119A, GLY119F, GLY153A, GLY159A, GLY178A, GLY178F, GLY217F, GLY227F, HIS108F, HIS172F, HIS179A, HIS179F, ILE161A, ILE167F, ILE233A, LEU105F, LEU124F, LEU143A, LEU143F, LEU147A, LEU147F, LEU164F, LEU168F, LEU175F, LEU188F, LEU214F, LEU220A, LEU221A, LEU241A, LEU243A, LEU246A, LYS121F, LYS213F, LYS225A, LYS225F, LYS235A, MET122A, MET122F, PHE116F, PHE155A, PHE230A, PRO216F, PRO234A, PRO98A, SER118A, SER162A, SER219A, SER99A, THR112F, THR117A, THR117F, THR125F, THR140A, THR148F, THR154A, THR163A, THR163F, THR209A, THR224A, THR224F, TRP187F, TYR101A, TYR228F, VAL113F, VAL115F, VAL141A, VAL150A, VAL158A, VAL176F, VAL177F, VAL185F, VAL186F, VAL222A, VAL238A, VAL242A, VAL247A
• A-G: ASP240A, ASP240G, GLU239A, GLU239G, GLU244A, GLU244G, GLU245A, GLU245G, LEU241A, LEU241G, LEU243A, LEU243G, LEU246A, LEU246G, VAL238A, VAL238G, VAL242A, VAL242G, VAL247A, VAL247G
• A-L: GLU203A, GLU237L, GLU239A, GLU239L
• B-C: ALA106B, ALA146B, ALA157C, ALA169B, ALA174B, ALA180B, ALA180C, ALA226B, ALA229B, ALA236C, ARG120B, ARG123B, ARG142C, ARG165B, ARG173B, ARG184B, ARG212B, ARG215B, ARG232C, ASN129C, ASN144C, ASP110B, ASP114B, ASP170B, ASP181B, ASP199B, ASP218B, ASP223B, ASP223C, ASP240C, GLU145B, GLU145C, GLU151C, GLU156C, GLU160C, GLU166B, GLU182B, GLU182C, GLU183B, GLU231C, GLU237C, GLU239C, GLU244C, GLU245C, GLY100C, GLY102C, GLY119B, GLY119C, GLY153C, GLY159C, GLY178B, GLY178C, GLY217B, GLY227B, HIS108B, HIS172B, HIS179B, HIS179C, ILE161C, ILE167B, ILE233C, LEU105B, LEU124B, LEU143B, LEU143C, LEU147B, LEU147C, LEU164B, LEU168B, LEU175B, LEU188B, LEU214B, LEU220C, LEU221C, LEU241C, LEU243C, LEU246C, LYS121B, LYS213B, LYS225B, LYS225C, LYS235C, MET122B, PHE116B, PHE155C, PHE230C, PRO216B, PRO234C, PRO98C, SER118C, SER162C, SER219C, SER99C, THR112B, THR117B, THR117C, THR125B, THR140C, THR148B, THR154C, THR163B, THR163C, THR209C, THR224B, THR224C, TRP187B, TYR101C, TYR228B, VAL113B, VAL115B, VAL141C, VAL149B, VAL150C, VAL158C, VAL176B, VAL177B, VAL185B, VAL186B, VAL222C, VAL238C, VAL242C, VAL247C
• B-K: GLU237K, GLU239B
• B-L: ASP240B, ASP240L, GLU239B, GLU239L, GLU244B, GLU244L, GLU245B, GLU245L, LEU241B, LEU241L, LEU243B, LEU243L, LEU246B, LEU246L, VAL238B, VAL238L, VAL242B, VAL242L, VAL247B, VAL247L
• C-D: ALA106C, ALA146C, ALA157D, ALA169C, ALA174C, ALA180C, ALA180D, ALA226C, ALA229C, ALA236D, ARG120C, ARG120D, ARG123C, ARG142D, ARG165C, ARG173C, ARG184C, ARG212C, ARG215C, ARG232D, ASN144D, ASP110C, ASP114C, ASP170C, ASP181C, ASP199C, ASP218C, ASP223C, ASP223D, ASP240D, GLU145C, GLU145D, GLU151D, GLU156D, GLU160D, GLU166C, GLU182C, GLU182D, GLU183C, GLU231D, GLU237D, GLU239D, GLU244D, GLU245D, GLY100D, GLY102D, GLY119C, GLY119D, GLY153D, GLY159D, GLY178C, GLY178D, GLY217C, GLY227C, HIS108C, HIS172C, HIS179C, HIS179D, ILE161D, ILE167C, ILE233D, LEU105C, LEU124C, LEU143C, LEU143D, LEU147C, LEU147D, LEU164C, LEU168C, LEU175C, LEU188C, LEU214C, LEU220D, LEU221D, LEU241D, LEU243D, LEU246D, LYS121C, LYS213C, LYS225C, LYS225D, LYS235D, MET122C, MET122D, PHE116C, PHE155D, PHE230D, PRO216C, PRO234D, PRO98D, SER118D, SER162D, SER219D, SER99D, THR112C, THR117C, THR117D, THR125C, THR140D, THR148C, THR154D, THR163C, THR163D, THR209D, THR224C, THR224D, TRP187C, TYR101D, TYR228C, VAL113C, VAL115C, VAL141D, VAL150D, VAL158D, VAL176C, VAL177C, VAL177D, VAL185C, VAL186C, VAL222D, VAL238D, VAL242D, VAL247D
• C-J: GLU237C, GLU237J, GLU239C, GLU239J
• C-K: ASP240C, ASP240K, GLU239C, GLU239K, GLU244C, GLU244K, GLU245C, GLU245K, LEU241C, LEU241K, LEU243C, LEU243K, LEU246C, LEU246K, VAL238C, VAL238K, VAL242C, VAL242K, VAL247C, VAL247K
• D-E: ALA106D, ALA146D, ALA157E, ALA169D, ALA174D, ALA180D, ALA180E, ALA226D, ALA229D, ALA236E, ARG120D, ARG120E, ARG123D, ARG142E, ARG165D, ARG173D, ARG184D, ARG212D, ARG215D, ARG232E, ASN144E, ASP110D, ASP114D, ASP170D, ASP181D, ASP199D, ASP218D, ASP223D, ASP223E, ASP240E, GLU145D, GLU145E, GLU151E, GLU156E, GLU160E, GLU166D, GLU182D, GLU182E, GLU183D, GLU231E, GLU237E, GLU239E, GLU244E, GLU245E, GLY100E, GLY102E, GLY119D, GLY119E, GLY153E, GLY159E, GLY178D, GLY178E, GLY217D, GLY227D, HIS108D, HIS172D, HIS179D, HIS179E, ILE161E, ILE167D, ILE233E, LEU105D, LEU124D, LEU143E, LEU147D, LEU147E, LEU164D, LEU168D, LEU175D, LEU188D, LEU214D, LEU220E, LEU221E, LEU241E, LEU243E, LEU246E, LYS121D, LYS213D, LYS225D, LYS225E, LYS235E, MET122D, MET122E, PHE116D, PHE155E, PHE230E, PRO216D, PRO234E, PRO98E, SER118D, SER118E, SER162E, SER219E, SER99E, THR112D, THR117E, THR125D, THR140E, THR148D, THR154E, THR163D, THR163E, THR224D, THR224E, TRP187D, TYR101E, TYR228D, VAL113D, VAL115D, VAL141E, VAL150E, VAL158E, VAL176D, VAL177D, VAL185D, VAL186D, VAL222E, VAL238E, VAL242E, VAL247E
• D-I: GLU237I, GLU239D
• D-J: ASP240D, ASP240J, GLU239D, GLU239J, GLU244D, GLU244J, GLU245D, GLU245J, LEU241D, LEU241J, LEU243D, LEU243J, LEU246D, LEU246J, VAL238D, VAL238J, VAL242D, VAL242J, VAL247D, VAL247J
• E-F: ALA106E, ALA146E, ALA157F, ALA169E, ALA174E, ALA180E, ALA180F, ALA226E, ALA229E, ALA236F, ARG120E, ARG123E, ARG142F, ARG165E, ARG173E, ARG184E, ARG215E, ARG232F, ASN144F, ASP110E, ASP114E, ASP170E, ASP181E, ASP218E, ASP223F, ASP240F, GLU145E, GLU145F, GLU151F, GLU156F, GLU160F, GLU166E, GLU182E, GLU182F, GLU183E, GLU231F, GLU237F, GLU239F, GLU244F, GLU245F, GLY100F, GLY102F, GLY119E, GLY153F, GLY159F, GLY178E, GLY178F, GLY217E, GLY227E, HIS108E, HIS172E, HIS179E, HIS179F, ILE161F, ILE167E, ILE233F, LEU105E, LEU124E, LEU143E, LEU143F, LEU147E, LEU164E, LEU168E, LEU175E, LEU188E, LEU214E, LEU220F, LEU221F, LEU241F, LEU243F, LEU246F, LYS121E, LYS225E, LYS235F, MET122E, PHE116E, PHE155F, PHE230F, PRO216E, PRO234F, PRO98F, SER118F, SER162F, SER219F, SER99F, THR112E, THR117E, THR117F, THR125E, THR140F, THR148E, THR154F, THR163E, THR163F, THR209F, THR224E, THR224F, TRP187E, TYR101F, TYR228E, VAL113E, VAL115E, VAL141F, VAL149E, VAL150F, VAL158F, VAL176E, VAL177E, VAL185E, VAL186E, VAL222F, VAL238F, VAL242F, VAL247F
• E-H: GLU237E, GLU237H, GLU239E, GLU239H
• E-I: ASP240E, ASP240I, GLU239E, GLU239I, GLU244E, GLU244I, GLU245E, GLU245I, LEU241E, LEU241I, LEU243E, LEU243I, LEU246E, LEU246I, VAL238E, VAL238I, VAL242E, VAL242I, VAL247E, VAL247I
• F-G: GLU237F, GLU237G, GLU239F, GLU239G
• F-H: ASP240F, ASP240H, GLU239F, GLU239H, GLU244F, GLU244H, GLU245F, GLU245H, LEU241F, LEU241H, LEU243F, LEU243H, LEU246F, LEU246H, VAL238F, VAL238H, VAL242F, VAL242H, VAL247F, VAL247H
• G-H: ALA106G, ALA146G, ALA157H, ALA169G, ALA174G, ALA180G, ALA180H, ALA226G, ALA229G, ALA236H, ARG120G, ARG123G, ARG142H, ARG165G, ARG173G, ARG184G, ARG212G, ARG215G, ARG232H, ASN144H, ASP110G, ASP114G, ASP170G, ASP181G, ASP218G, ASP223G, ASP223H, ASP240H, GLU145G, GLU145H, GLU151H, GLU156H, GLU160H, GLU166G, GLU182G, GLU182H, GLU183G, GLU231H, GLU237H, GLU239H, GLU244H, GLU245H, GLY100H, GLY102H, GLY119G, GLY119H, GLY153H, GLY159H, GLY178G, GLY178H, GLY200G, GLY217G, GLY227G, HIS108G, HIS172G, HIS179G, HIS179H, ILE161H, ILE167G, ILE233H, LEU105G, LEU124G, LEU143G, LEU143H, LEU147G, LEU147H, LEU164G, LEU168G, LEU175G, LEU188G, LEU214G, LEU220H, LEU221H, LEU241H, LEU243H, LEU246H, LYS121G, LYS213G, LYS225G, LYS225H, LYS235H, MET122G, MET122H, PHE116G, PHE155H, PHE230H, PRO216G, PRO234H, PRO98H, SER118H, SER162H, SER219H, SER99H, THR112G, THR117G, THR117H, THR125G, THR140H, THR148G, THR154H, THR163G, THR163H, THR209H, THR224G, THR224H, TRP187G, TYR101H, TYR228G, VAL113G, VAL115G, VAL141H, VAL150H, VAL158H, VAL176G, VAL177G, VAL185G, VAL186G, VAL222H, VAL238H, VAL242H, VAL247H
• G-L: ALA106L, ALA146L, ALA157G, ALA169L, ALA174L, ALA180G, ALA180L, ALA226L, ALA229L, ALA236G, ARG120L, ARG123L, ARG142G, ARG165L, ARG173L, ARG184L, ARG212L, ARG215L, ARG232G, ASN144G, ASP110L, ASP114L, ASP170L, ASP181L, ASP218L, ASP223G, ASP223L, ASP240G, GLU145G, GLU145L, GLU151G, GLU156G, GLU160G, GLU166L, GLU182G, GLU182L, GLU183L, GLU231G, GLU237G, GLU239G, GLU244G, GLU245G, GLY100G, GLY102G, GLY119G, GLY119L, GLY153G, GLY159G, GLY178G, GLY178L, GLY217L, GLY227L, HIS108L, HIS172L, HIS179G, HIS179L, ILE161G, ILE167L, ILE233G, LEU105L, LEU124L, LEU143G, LEU143L, LEU147G, LEU147L, LEU164L, LEU168L, LEU175L, LEU188L, LEU214L, LEU220G, LEU221G, LEU241G, LEU243G, LEU246G, LYS121L, LYS213L, LYS225G, LYS225L, LYS235G, MET122G, MET122L, PHE155G, PHE230G, PRO216L, PRO234G, PRO98G, SER118G, SER162G, SER219G, SER99G, THR112L, THR117G, THR117L, THR125L, THR140G, THR148L, THR154G, THR163G, THR163L, THR209G, THR224G, THR224L, TRP187L, TYR101G, TYR228L, VAL113L, VAL115L, VAL141G, VAL150G, VAL158G, VAL176L, VAL177L, VAL185L, VAL186L, VAL222G, VAL238G, VAL242G, VAL247G
• H-I: ALA106H, ALA146H, ALA157I, ALA169H, ALA174H, ALA180H, ALA180I, ALA226H, ALA229H, ALA236I, ARG120H, ARG120I, ARG123H, ARG142I, ARG165H, ARG173H, ARG184H, ARG210I, ARG212H, ARG215H, ARG232I, ASN144I, ASP110H, ASP114H, ASP170H, ASP181H, ASP199H, ASP218H, ASP223H, ASP223I, ASP240I, GLU145H, GLU145I, GLU151I, GLU156I, GLU160I, GLU166H, GLU182H, GLU182I, GLU183H, GLU231I, GLU237I, GLU239I, GLU244I, GLU245I, GLY100I, GLY102I, GLY119H, GLY119I, GLY153I, GLY159I, GLY178H, GLY178I, GLY217H, GLY227H, HIS108H, HIS172H, HIS179H, HIS179I, ILE161I, ILE167H, ILE233I, LEU105H, LEU124H, LEU143I, LEU147H, LEU147I, LEU164H, LEU168H, LEU175H, LEU188H, LEU214H, LEU220I, LEU221I, LEU241I, LEU243I, LEU246I, LYS121H, LYS213H, LYS225H, LYS235I, MET122H, MET122I, PHE116H, PHE116I, PHE155I, PHE230I, PRO216H, PRO234I, PRO98I, SER118I, SER162I, SER219I, SER99I, THR112H, THR117H, THR117I, THR125H, THR140I, THR148H, THR154I, THR163H, THR163I, THR209I, THR224H, THR224I, TRP187H, TYR101I, TYR228H, VAL113H, VAL115H, VAL141I, VAL150I, VAL158I, VAL176H, VAL177H, VAL185H, VAL186H, VAL222I, VAL238I, VAL242I, VAL247I
• I-J: ALA106I, ALA146I, ALA152J, ALA157J, ALA169I, ALA174I, ALA180I, ALA180J, ALA226I, ALA229I, ALA236J, ARG120I, ARG120J, ARG123I, ARG142J, ARG165I, ARG173I, ARG184I, ARG212I, ARG215I, ARG232J, ASN144J, ASP110I, ASP114I, ASP170I, ASP181I, ASP199I, ASP218I, ASP223I, ASP223J, ASP240J, GLU145I, GLU145J, GLU151J, GLU156J, GLU160J, GLU166I, GLU182I, GLU182J, GLU183I, GLU231J, GLU237J, GLU239J, GLU244J, GLU245J, GLY100J, GLY102J, GLY119I, GLY119J, GLY153J, GLY159J, GLY178I, GLY178J, GLY217I, GLY227I, HIS108I, HIS172I, HIS179I, HIS179J, ILE161J, ILE167I, ILE233J, LEU105I, LEU124I, LEU143I, LEU143J, LEU147I, LEU147J, LEU164I, LEU168I, LEU175I, LEU188I, LEU214I, LEU220J, LEU221J, LEU241J, LEU243J, LEU246J, LYS121I, LYS137I, LYS213I, LYS225I, LYS225J, LYS235J, MET122I, MET122J, PHE116I, PHE155J, PHE230J, PRO216I, PRO234J, PRO98J, SER118J, SER162J, SER219J, SER99J, THR112I, THR117I, THR117J, THR125I, THR140J, THR148I, THR154J, THR163I, THR163J, THR209J, THR224I, THR224J, TRP187I, TYR101J, TYR228I, VAL113I, VAL115I, VAL141J, VAL149I, VAL150J, VAL158J, VAL176I, VAL177I, VAL177J, VAL185I, VAL186I, VAL222J, VAL238J, VAL242J, VAL247J
• J-K: ALA106J, ALA146J, ALA157K, ALA169J, ALA174J, ALA180J, ALA180K, ALA226J, ALA229J, ALA236K, ARG120J, ARG123J, ARG142K, ARG165J, ARG173J, ARG184J, ARG212J, ARG215J, ARG232K, ASN144K, ASP110J, ASP114J, ASP170J, ASP181J, ASP199J, ASP218J, ASP223J, ASP223K, ASP240K, GLU145J, GLU145K, GLU151K, GLU156K, GLU160K, GLU166J, GLU182J, GLU182K, GLU183J, GLU231K, GLU237K, GLU239K, GLU244K, GLU245K, GLY100K, GLY102K, GLY119J, GLY119K, GLY153K, GLY159K, GLY178J, GLY178K, GLY217J, GLY227J, HIS108J, HIS172J, HIS179J, HIS179K, ILE161K, ILE167J, ILE233K, LEU105J, LEU124J, LEU143J, LEU143K, LEU147J, LEU147K, LEU164J, LEU168J, LEU175J, LEU188J, LEU214J, LEU220K, LEU221K, LEU241K, LEU243K, LEU246K, LYS121J, LYS137J, LYS213J, LYS225J, LYS225K, LYS235K, MET122J, PHE116J, PHE155K, PHE230K, PRO216J, PRO234K, PRO98K, SER118K, SER162K, SER219K, SER99K, THR112J, THR117J, THR117K, THR125J, THR140K, THR148J, THR154K, THR163J, THR163K, THR209K, THR224J, THR224K, TRP187J, TYR101K, TYR228J, VAL113J, VAL115J, VAL141K, VAL150K, VAL158K, VAL176J, VAL177J, VAL185J, VAL186J, VAL222K, VAL238K, VAL242K, VAL247K
• K-L: ALA106K, ALA146K, ALA157L, ALA169K, ALA174K, ALA180K, ALA180L, ALA226K, ALA229K, ALA236L, ARG120K, ARG123K, ARG142L, ARG165K, ARG173K, ARG184K, ARG212K, ARG215K, ARG232L, ASN144L, ASP110K, ASP114K, ASP170K, ASP181K, ASP218K, ASP223K, ASP223L, ASP240L, GLU145K, GLU145L, GLU151L, GLU156L, GLU160L, GLU166K, GLU182K, GLU182L, GLU183K, GLU231L, GLU237L, GLU239L, GLU244L, GLU245L, GLY100L, GLY102L, GLY119K, GLY119L, GLY153L, GLY159L, GLY178K, GLY178L, GLY217K, GLY227K, HIS108K, HIS172K, HIS179K, HIS179L, ILE161L, ILE167K, ILE233L, LEU105K, LEU124K, LEU143K, LEU143L, LEU147K, LEU147L, LEU164K, LEU168K, LEU175K, LEU188K, LEU214K, LEU220L, LEU221L, LEU241L, LEU243L, LEU246L, LYS121K, LYS213K, LYS225K, LYS235L, MET122K, MET122L, PHE116K, PHE155L, PHE230L, PRO216K, PRO234L, PRO98L, SER118L, SER162L, SER219L, SER99L, THR112K, THR117K, THR117L, THR125K, THR140L, THR148K, THR154L, THR163K, THR163L, THR224K, THR224L, TRP187K, TYR101L, TYR228K, VAL113K, VAL115K, VAL141L, VAL150L, VAL158L, VAL176K, VAL177K, VAL185K, VAL186K, VAL222L, VAL238L, VAL242L, VAL247L